Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer
Reid Powell, "Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer." NPJ Breast Cancer, 2024.
Reid Powell, "Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer." NPJ Breast Cancer, 2024.
Sara Johnson, Hannah Johnson, Reid Powell, Clifford Stephan, Fabio Stossi, Thomas Cooper. "Small-Molecule-Screening-Identifies-HSP90-as-a-Modifier-of-RNA-Foci-in-Myotonic-Dystrophy-Type-1." Molecular and Cellular Biology, 2024.
Amanda Rinkenbaugh, "PDX models of TNBC established from pre-and post-therapy tumors identify vulnerabilities of resistant disease." Cancer Research, 2024.
Robiya Joseph, "EphA2 and HDAC-Targeted Combination Therapy in Endometrial Cancer." International journal of molecular sciences, 2024.
Susmita Ghosh, Fan Fan, Reid Powell, Yong Park, Clifford Stephan, Scott Kopetz, Lee Ellis, Rajat Bhattacharya. "Enhancing-efficacy-of-the-MEK-inhibitor-trametinib-with-paclitaxel-in-KRAS-mutated-colorectal-cancer." bioRxiv, 2024.
Aidi Liu, Mithil Chokshi, Nghi Nguyen, Reid Powell, Clifford Stephan, Gang Bao. "Cystic-fibrosis-cell-models-for-high-throughput-analysis-and-drug-screening." Journal of Cystic Fibrosis, 2024.
Ravi Marreddy, Gregory Phelps, Kelly Churion, Jonathan Picker, Reid Powell, Philip Cherian, John Bowling, Clifford Stephan, Richard Lee, Julian Hurdle. "Chemical-genetic-analysis-of-enoxolone-inhibition-of-C.-difficile-toxin-production-reveals-adenine-deaminase-and-ATP-synthase-as-anti-virulence-targets." Journal of Biological Chemistry, 2024.
Susmita Ghosh, "Vincristine enhances the efficacy of MEK inhibitors in preclinical models of KRAS-mutant colorectal cancer." Molecular cancer therapeutics, 2023.
Reid Powell, Mark Endsley, Walter Cromer. "The-Effects-of-Transplantation-of-the-Spaceflight-Intestinal-Microbiome-on-Short-Chain-Fatty-Acid-Production,-Lymphoid-organ-Immune-Composition-and-Transport-Kinetics." Unknown Venue, 2023.
Thomas Welte, Veena Vuttaradhi, Eleonora Khlebus, Barrett Lawson, Robert Hillman, Nghi Nguyen, Mary Sobieski, Reid Powell, Clifford Stephan. "Targeting-FOXL2C402G-vulnerabilities-in-adult-type-ovarian-granulosa-cell-tumors." Cancer Research, 2023.
Wangie Yu, "Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state." British journal of cancer, 2023.
Susmita Ghosh, Fan Fan, Jason Roszik, Reid Powell, Yong Park, Clifford Stephan, Lee Ellis, Rajat Bhattacharya. "Crizotinib-enhances-the-efficacy-of-BX-795-identified-by-high-throughput-screening-of-pan-active-drugs-in-colorectal-cancer-cells." Cancer Research, 2023.
Pooja Shah, Tuhina Mazumdar, Reid Powell, Li Shen, Jing Wang, Clifford Stephen, Mitchell Frederick, Faye Johnson. "Concurrent-inactivation-of-PI3K-and-PLK1-is-synergistic-and-overcomes-acquired-resistance-to-PI3K-inhibitors-in-NOTCH1-MUT-HNSCC." Cancer Research, 2023.
Fan Fan, "Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo." Plos one, 2023.
Santosh Dasari, "Combination of EphA2-and Wee1-targeted therapies in Endometrial Cancer." International journal of molecular sciences, 2023.
Noor Abdulkareem, "Abstract P6-10-19: Screening of GPCR-targeting drugs for repositioning in breast cancer." In the proceedings of Cancer Research, 2023.
Garrett Jensen, "Abstract P3060: Modeling Immune Checkpoint Inhibitor Associated Myocarditis In Vitro." In the proceedings of Circulation Research, 2023.
Susmita Ghosh, Fan Fan, Reid Powell, Yong Park, Clifford Stephan, Jason Roszik, Lee Ellis, Rajat Bhattacharya. "Abstract-B171:-BX-795-enhances-the-efficacy-of-crizotinib-in-colorectal-cancer-cells-by-altering-the-activity-of-aurora-kinases." In the proceedings of Molecular Cancer Therapeutics, 2023.
Jacob Junco, "A Novel Transgenic Mouse Model of Down Syndrome Acute Lymphoblastic Leukemia Identifies Targetable Vulnerabilities." Blood, 2023.
LM Ellis, S Ghosh, F Fan, R Bhattacharya, R Powell, YS Park, C Stephan. "35P-Enhancing-efficacy-of-the-MEK-inhibitor-trametinib-in-KRAS-mutated-colorectal-cancer-cells." ESMO Open, 2023.
Reid Powell, Micheline Moussalli, Lei Guo, Goeun Bae, Pankaj Singh, Clifford Stephan, Imad Shureiqi, Peter Davies. "deepOrganoid:-A-brightfield-cell-viability-model-for-screening-matrix-embedded-organoids." SLAS Discovery, 2022.
Evelyn Groot, Sruthy Varghese, Lin Tan, Barbara Knighton, Mary Sobieski, Nghi Nguyen, Yong Park, Reid Powell, Philip Lorenzi, Bin Zheng, Clifford Stephan, Y. Gopal. "Combined-inhibition-of-HMGCoA-reductase-and-mitochondrial-complex-I-induces-tumor-regression-of-BRAF-inhibitor-resistant-melanomas." Cancer & Metabolism, 2022.
Ravi Marreddy, Jonathan Picker, Gregory Phelps, Reid Powell, Philip Cherian, John Bowling, Clifford Stephan, Richard Lee, Julian Hurdle. "The-licorice-metabolite-enoxolone-attenuates-Clostridioides-difficile-pathophysiology-by-corrupting-its-metabolic-and-toxin-production-networks." bioRxiv, 2022.
Noor Abdulkareem, "Screening of GPCR drugs for repurposing in breast cancer." Frontiers in Pharmacology, 2022.
Soma Ghosh, Tuhina Mazumdar, Wei Xu, Reid Powell, Clifford Stephan, Li Shen, Curtis Pickering, Jing Wang, Faye Johnson. "Rb-deficient-HPV+-HNSCC-experienced-enhanced-sensitivity-to-aurora-kinase-inhibitors-by-altering-the-balance-of-MAD2-and-TRIP13-levels." Cancer Research, 2022.
Yi-Ching Tang, Reid Powell, Assaf Gottlieb. "Molecular-pathways-enhance-drug-response-prediction-using-transfer-learning-from-cell-lines-to-tumors-and-patient-derived-xenografts." Scientific Reports, 2022.
Susmita Ghosh, Fan Fan, Jason Roszik, Reid Powell, Yong Park, Clifford Stephan, Lee Ellis, Rajat Bhattacharya. "Determining-efficacy-of-combining-the-MEK-inhibitor-trametinib-with-vincristine-identified-by-unbiased-high-throughput-screening-in-RAS-mutated-colorectal-cancer-cells." Cancer Research, 2022.
Ashwani Kumar, "Chemically targeting the redox switch in AP1 transcription factor $Delta$FOSB." Nucleic acids research, 2022.
William Tahaney, "Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells." In the proceedings of Cancer Research, 2022.
Michael Bolt, Pankaj Singh, Caroline Obkirchner, Reid Powell, Maureen Mancini, Adam Szafran, Fabio Stossi, Michael Mancini. "Endocrine-disrupting-chemicals-differentially-alter-intranuclear-dynamics-and-transcriptional-activation-of-estrogen-receptor-$upalpha$." iScience, 2021.
Katelyn Handley, Cristian Rodriguez-Aguayo, Shaolin Ma, Elaine Stur, Robiya Joseph, Emine Bayraktar, Santosh Dasari, Nghi Nguyen, Reid Powell, Mary Sobieski, Cristina Ivan, Mark Kim, Sujanitha Umamaheswaran, Deanna Glassman, Yunfei Wen, Paola Amero, Clifford Stephan, Robert Coleman, Yosef Landesman, Shannon Westin, Prahlad Ram, Anil Sood. "Rational-Combination-of-CRM1-Inhibitor-Selinexor-and-Olaparib-Shows-Synergy-in-Ovarian-Cancer-Cell-Lines-and-Mouse-Models." Molecular Cancer Therapeutics, 2021.
Vrutant Shah, Aundrietta Duncan, Shiming Jiang, Sabrina Stratton, Kendra Allton, Clinton Yam, Abhinav Jain, Patrick Krause, Yue Lu, Shirong Cai, Yizheng Tu, Xinhui Zhou, Xiaomei Zhang, Yan Jiang, Christopher Carroll, Zhijun Kang, Bin Liu, Jianjun Shen, Mihai Gagea, Sebastian Manu, Lei Huo, Michael Gilcrease, Reid Powell, Lei Guo, Clifford Stephan, Peter Davies, Jan Parker-Thornburg, Guillermina Lozano, Richard Behringer, Helen Piwnica-Worms, Jeffrey Chang, Stacy Moulder, Michelle Barton. "Mammary-specific-expression-of-Trim24-establishes-a-mouse-model-of-human-metaplastic-breast-cancer." Nature Communications, 2021.
Na Zhao, Reid Powell, Xueying Yuan, Goeun Bae, Kevin Roarty, Fabio Stossi, Martina Strempfl, Michael Toneff, Hannah Johnson, Sendurai Mani, Philip Jones, Clifford Stephan, Jeffrey Rosen. "Morphological-screening-of-mesenchymal-mammary-tumor-organoids-to-identify-drugs-that-reverse-epithelial-mesenchymal-transition." Nature Communications, 2021.
Ying Henderson, Abdallah Mohamed, Anastasios Maniakas, Yunyun Chen, Reid Powell, Shaohua Peng, Maria Cardenas, Michelle Williams, Diana Bell, Mark Zafereo, Rui Wang, Steve Scherer, David Wheeler, Maria Cabanillas, Marie-Claude Hofmann, Faye Johnson, Clifford Stephan, Vlad Sandulache, Stephen Lai. "A-High-Throughput-Approach-to-Identify-Effective-Systemic-Agents-for-the-Treatment-of-Anaplastic-Thyroid-Carcinoma." The Journal of Clinical Endocrinology & Metabolism, 2021.
Pratim Chowdhury, Dimuthu Perera, Reid Powell, Tia Talley, Durga Tripathi, Yong Park, Michael Mancini, Peter Davies, Clifford Stephan, Cristian Corfa, Ruhee Dere. "Therapeutically-actionable-signaling-node-to-rescue-AURKA-driven-loss-of-primary-cilia-in-VHL-deficient-cells." Scientific Reports, 2021.
Pratim Chowdhury, "Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells." Scientific Reports, 2021.
Sean Post, "Targeting the Oncogenic Functions of an RNA-Binding Protein Involved in Hematologic Malignancies." Blood, 2021.
Pooja Shah, Tuhina Mazumdar, Reid Powell, Li Shen, Jing Wang, Clifford Stephen, Mitchell Frederick, Faye Johnson. "Identification-of-pathways-that-enhance-cell-death-in-NOTCH1-mutant-HNSCC." Cancer Research, 2021.
Michael Bolt, Pankaj Singh, Caroline Obkirchner, Reid Powell, Maureen Mancini, Adam Szafran, Fabio Stossi, Michael Mancini. "Endocrine-disrupting-chemicals-differentially-alter-intranuclear-dynamics-and-transcriptional-activation-of-estrogen-receptor-$alpha$." Iscience, 2021.
Pratim Chowdhury, "Author Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells." Scientific Reports, 2021.
Tuhina Mazumdar, Li Shen, Wei Xu, Soma Ghosh, Reid Powell, Clifford Stephan, Curtis Pickering, Jeffery Myers, Jing Wang, Faye Johnson. "Aurora-kinase-inhibitors-cause-cell-death-in-HPV+-cells:-A-plausible-treatment-option-for-HPV+-cancers." Cancer Research, 2021.
Reid Powell, Fan Fan, Mary Sobieski, David Brunell, Rui Wang, Xiangcang Ye, Clifford Stephan, Lee Ellis, Rajat Bhattacharya. "Unbiased-high-throughput-screenings-to-identify-combination-therapies-targeting-RAS-mutated-colorectal-cancer.." Unknown Venue, 2020.
Reid Powell, Abena Redwood, Xuan Liu, Lei Guo, Shirong Cai, Xinhui Zhou, Yizheng Tu, Xiaomei Zhang, Yuan Qi, Yan Jiang, Gloria Echeverria, Ningping Feng, XiaoYan Ma, Virginia Giuliani, Joseph Marszalek, Timothy Heffernan, Christopher Vellano, Jason White, Clifford Stephan, Peter Davies, Stacy Moulder, W. Symmans, Jeffrey Chang, Helen Piwnica-Worms. "Pharmacologic-profiling-of-patient-derived-xenograft-models-of-primary-treatment-na"ive-triple-negative-breast-cancer." Unknown Venue, 2020.
Reid Powell, "High throughput chemical profiling of chemoresistant triple negative breast cancer." Cancer Research, 2020.
Fan Fan, Reid Powell, Jason Roszik, Rui Wang, Xiangcang Ye, Clifford Stephan, Lee Ellis, Rajat Bhattacharya. "Determining-efficacy-of-drug-combinations-identified-by-unbiased-high-throughput-screening-for-RAS-mutated-colorectal-cancer." Cancer Research, 2020.
William Tahaney, Reid Powell, Nghi Nguyen, Lakshmi Bollu, Jing Qian, Abhijit Mazumdar, Clifford Stephan, Peter Davies, Powel Brown. "Abstract-P3-03-08:-Identification-of-drugs-that-induce-the-death-or-suppress-the-growth-of-p53-mutant-breast-cancer." In the proceedings of Cancer Research, 2020.
Reid Powell, Fan Fan, Mary Sobieski, David Brunell, Rui Wang, Xiangcang Ye, Clifford Stephan, Lee Ellis, Rajat Bhattacharya. "Abstract-B20:-Unbiased-high-throughput-screenings-to-identify-combination-therapies-targeting-RAS-mutated-colorectal-cancer." In the proceedings of Molecular Cancer Research, 2020.
Vincent Bernard, "Single cell transcriptomic profiling of ex vivo tumoroid models reveal therapeutic vulnerabilities of pancreatic ductal adenocarcinoma." Cancer Research, 2019.
Paul Wadsworth, Oluwarotimi Folorunso, Nghi Nguyen, Aditya Singh, Daniela D{\textquoteright}Amico, Reid Powell, David Brunell, John Allen, Clifford Stephan, Fernanda Laezza. "High-throughput-screening-against-protein:protein-interaction-interfaces-reveals-anti-cancer-therapeutics-as-potent-modulators-of-the-voltage-gated-Na+-channel-complex." Unknown Venue, 2019.
J. Xia, L.-Y. Chiu, R.B. Nehring, M.A. Bravo, Q. Mei, M. Perez, Y. Zhai, D.M. Fitzgerald, J.P. Pribis, Y. Wang, C.W. Hu, R.T. Powell, S.A. LaBonte, A. Jalali, M.L. Matadamas, A.M. Lentzsch, A.T. Szafran, M.C. Joshi, M. Richters, J.L. Gibson, R.L. Frisch, P.J. Hastings, D. Bates, C. Queitsch, S.G. Hilsenbeck, C. Coarfa, J.C. Hu, D.A. Siegele, K.L. Scott, H. Liang, M.A. Mancini, C. Herman, K.M. Miller, S.M. Rosenberg. "Bacteria-to-Human-Protein-Networks-Reveal-Origins-of-Endogenous-DNA-Damage." Cell, 2019.
Reid Powell. "Extracting-Biological-Knowledge-from-High-Throughput-Phenotypic-Screens." Unknown Venue, 2018.
P. Chowdhury, R.T. Powell, C. Stephan, I.P. Uray, T. Talley, M. Karki, D.N. Tripathi, Y.S. Park, M.A. Mancini, P. Davies, R. Dere. "Bexarotene-?-A-novel-modulator-of-AURKA-and-the-primary-cilium-in-VHL-deficient-cells." Journal of Cell Science, 2018.
E Jonasch, "The role of hepatocyte nuclear factor 1 homeobox B (HNF1B) loss in chromophobe RCC (ChRCC) development." Annals of Oncology, 2017.
Michael Lehrer, Reid Powell, Souptik Barua, Donnie Kim, Shivali Narang, Arvind Rao. "Radiogenomics-and-histomics-in-glioblastoma:-the-promise-of-linking-image-derived-phenotype-with-genomic-information." Advances in Biology and Treatment of Glioblastoma, 2017.
M. Sun, P. Tong, W. Kong, B. Dong, Y. Huang, I.Y. Park, L. Zhou, X.-D. Liu, Z. Ding, X. Zhang, S. Bai, P. German, R. Powell, Q. Wang, X. Tong, N.M. Tannir, S.F. Matin, W.K. Rathmell, G.N. Fuller, I.E. McCutcheon, C.L. Walker, J. Wang, E. Jonasch. "HNF1B-loss-exacerbates-the-development-of-chromophobe-renal-cell-carcinomas." Cancer Research, 2017.
I.Y. Park, R.T. Powell, D.N. Tripathi, R. Dere, T.H. Ho, T.L. Blasius, Y.-C. Chiang, I.J. Davis, C.C. Fahey, K.E. Hacker, K.J. Verhey, M.T. Bedford, E. Jonasch, W.K. Rathmell, C.L. Walker. "Dual-Chromatin-and-Cytoskeletal-Remodeling-by-SETD2." Cell, 2016.
J. Zhang, D.N. Tripathi, J. Jing, A. Alexander, J. Kim, R.T. Powell, R. Dere, J. Tait-Mulder, J.-H. Lee, T.T. Paull, R.K. Pandita, V.K. Charaka, T.K. Pandita, M.B. Kastan, C.L. Walker. "ATM-functions-at-the-peroxisome-to-induce-pexophagy-in-response-to-ROS." Nature Cell Biology, 2015.
F. Stossi, M.J. Bolt, F.J. Ashcroft, J.E. Lamerdin, J.S. Melnick, R.T. Powell, R.D. Dandekar, M.G. Mancini, C.L. Walker, J.K. Westwick, M.A. Mancini. "Defining-estrogenic-mechanisms-of-bisphenol-A-analogs-through-high-throughput-microscopy-based-contextual-assays." Chemistry and Biology, 2014.