UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    7.7962   -1.5128    0.0000 C   0  0
    6.4994   -0.7589    0.0000 O   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    3.9015    0.7475    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  7 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28087

> <plate>
Kinase v5-1

> <well>
A03

> <supplier_cmpd_name>
PD-98059

> <ctcr_id>
4311

> <supplier_cmpd_id>
EI-360

> <smiles>
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

> <pd_targets>
{HPGD,CYP3A4,CYP1A2,MAPK1,PTGS1,SMN1,TSHR,MAPT,CYP2C19,PYK,MAP2K1,ALDH1A1,PMP22,PKM,ALOX15,THPO,TP53,CYP2D6,CYP2C9,KMT2A,MEN1,LEF,BLM,NPC1,CHRM1,RAF1,RAB9A,MAP2K2,GMNN,RORC}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Membrane receptor","Other cytosolic protein","Unclassified protein","Transcription factor",Transporter,"Cytochrome P450",Kinase,Oxidoreductase,Reader,"Family A G protei
n-coupled receptor",Transferase,Protease,Hydrolase,"Nuclear receptor","Cytochrome P450 family 3","Cytochrome P450 family 1","Protein Kinase","Methyl-lysine/arginine binding protein","Peptide receptor 
(family A GPCR)","Cytochrome P450 family 2",Bromodomain,"Metallo protease","Small molecule receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3A","Cytochrome P450
 family 1A","CMGC protein kinase group","Tudor domain","Glycohormone receptor","Cytochrome P450 family 2C","STE protein kinase group","Cytochrome P450 family 2D","Metallo protease MAE clan","Monoamine
 receptor","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 3A4","Cytochrome P450 1A1","CMGC protein kinase MAPK family","Cytochrome P450 2C19","STE protein kinase STE7 family","Cytochr
ome P450 2D6","Cytochrome P450 2C9","Metallo protease M34 family","Acetylcholine receptor","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Eicosanoid turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","G protein-coupled receptors","2.7.1.40 Pyruvate kinases","SLC superfamily of solute carriers","Nuclear h
ormone receptors","Prostaglandin synthases","CYP3 family","CYP1 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Cyclooxygenase,"Glycoprotein hormone receptors","CYP2 family: drug metabolising 
subset","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Lipoxygenases,"SLC65 NPC-type cholesterol transporters","Acetylcholine receptors (muscarinic)","1F. Retinoic acid-related o
rphans","Mitogen-activated protein kinases (MAP kinases)","STE7 family","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Immune System","Metabolism of RNA",Disease,"Neuronal System","Signal Transduction","Developmental Biology",Hemostasis,"Cell Cycle","DNA Repair","Transport of small molecules","Gene expres
sion (Transcription)","Metabolism of lipids","Biological oxidations","Innate Immune System","Metabolism of non-coding RNA","Infectious disease","Transmission across Chemical Synapses","Signaling by Re
ceptor Tyrosine Kinases","Nervous system development","Metabolism of carbohydrates","Platelet activation","signaling and aggregation","Cell Cycle Checkpoints","DNA Double-Strand Break Repair","Plasma 
lipoprotein assembly",remodeling,"and clearance","Signaling by GPCR","Signaling by Rho GTPases",Mitotic,"RNA Polymerase II Transcription","Biosynthesis of specialized proresolving mediators (SPMs)","P
hase I - Functionalization of compounds","Toll-like Receptor Cascades","Fatty acid metabolism","snRNP Assembly","Leishmania infection","Neurotransmitter receptors and postsynaptic signal transmission"
,"Signaling by NTRKs","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Glucose metabolism","Platelet Aggregation (Plug Formation)","G1/S DNA Damage Checkpoints","Uptake and actions of
 bacterial toxins","Homology Directed Repair","Plasma lipoprotein clearance","GPCR ligand binding","Rho GTPase cycle","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Biosynthes
is of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Toll Like Receptor 5 (TLR5) Cascade","Arachidonic acid metabolism","Leishmania parasite growth and survival","Activation of NMDA
 receptors and postsynaptic events","Signaling by NTRK1 (TRKA)","Ethanol oxidation",Glycolysis,"Biosynthesis of DPA-derived SPMs","p53-Dependent G1/S DNA damage checkpoint","Uptake and function of ant
hrax toxins","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","LDL clearance","Class A/1 (Rhodopsin-like receptors)","RHOBTB GTPase Cycle","G1/S Transition","Transcription
al regulation by RUNX3","Biosynthesis of D-series resolvins","Biosynthesis of maresins",Xenobiotics,"MyD88 cascade initiated on plasma membrane","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
","Anti-inflammatory response favouring Leishmania parasite infection","Post NMDA receptor activation events","Signalling to ERKs","Biosynthesis of DPAn-3 SPMs","p53-Dependent G1 DNA Damage Response",
"HDR through Homologous Recombination (HRR)","Amine ligand-binding receptors","RHOBTB3 ATPase cycle","Activation of the pre-replicative complex","RUNX3 Regulates Immune Response and Cell Migration","B
iosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP kinase activation","ADORA2B mediated anti-inflammatory cytokines production","Activation of AM
PK downstream of NMDARs","CYP2E1 reactions","Prolonged ERK activation events","Biosynthesis of DPAn-3-derived protectins and resolvins","Stabilization of p53","Homologous DNA Pairing and Strand Exchan
ge","Muscarinic acetylcholine receptors","MAPK targets/ Nuclear events mediated by MAP kinases","Frs2-mediated activation","Autodegradation of the E3 ubiquitin ligase COP1","Presynaptic phase of homol
ogous DNA pairing and strand exchange","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,CHEK1,GSK3B,LCK,MAP2K1,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,RAF1,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{167869-21-8,167869218,PD98059,"PD 98059",2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one,2(2amino3methoxyphenyl)4Hchromen4one,PD-98059,"PD 98,059",2-(2-amino-3-methoxyphenyl)chromen-4-one,2(2amino3metho
xyphenyl)chromen4one,2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one,2(2Amino3methoxyphenyl)4H1benzopyran4one,2'-AMINO-3'-METHOXYFLAVONE,2'AMINO3'METHOXYFLAVONE,PD-098059,PD098059,4H-1-Benzopyran-4-
one,4H1Benzopyran4one,T2623,"EMD 513000",S1177,1213,EI-360,513000}

> <pdid>
PD002681

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{4713}

$$$$
UTKinase_V5
  SciTegic11012413002D

 15 15  0  0  0  0            999 V2000
   -0.0034   -3.0047    0.0000 N   0  0
    1.2956   -3.7547    0.0000 C   0  0
    1.2951   -5.2547    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7537    0.0000 C   0  0
    3.9019    0.7463    0.0000 C   0  0
    5.2031    1.4926    0.0000 C   0  0
    6.4999    0.7389    0.0000 C   0  0
    7.8011    1.4852    0.0000 O   0  0
    6.4957   -0.7611    0.0000 C   0  0
    7.7926   -1.5148    0.0000 O   0  0
    5.1945   -1.5074    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1908   -4.5097    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 11 13  2  0
 13  6  1  0
  4 14  1  0
 14 15  3  0
M  END
> <name>
UTKinase_V5

> <id>
28088

> <plate>
Kinase v5-1

> <well>
A05

> <supplier_cmpd_name>
TYRPHOSTIN 46

> <ctcr_id>
7663

> <supplier_cmpd_id>
EI-257

> <smiles>
NC(=O)/C(=C/c1ccc(O)c(O)c1)C#N

> <pd_targets>
{TSHR,NFKB1,HSD17B10,MAPT,ALDH1A1,FFP,TDP1,ALOX15,CHRM1,CYP3A4,CYP2D6,SYK,DNM1,EGFR,HIF1A,KMT2A,MEN1,ALOX12,CYP1A2,IMPA1,MAPK1,HPGD,RECQL,KDM4E,CYP2C19,CSF1R,ERBB2,TP53,BLM,GAA,CYP2C9,PKM,ALD,LEF,GLA,
LCK,FTL,POLB,PMP22,APEX1,NPSR1}

> <pathway_gtopdb>
{"Membrane receptor","Other cytosolic protein",Enzyme,"Transcription factor","Epigenetic regulator","Family A G protein-coupled receptor",Oxidoreductase,Transferase,Protease,Hydrolase,"Cytochrome P450
",Kinase,Reader,Eraser,"Peptide receptor (family A GPCR)","Cysteine protease","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Protein Kinase",Bromodoma
in,"Cytochrome P450 family 1","Lysine demethylase","Metallo protease","Glycohormone receptor","Cysteine protease CA clan","Monoamine receptor","Cytochrome P450 family 3A","Cytochrome P450 family 2D","
TK protein kinase group","Cytochrome P450 family 1A","CMGC protein kinase group","Jumonji domain-containing","Cytochrome P450 family 2C","Metallo protease MAE clan","Cysteine protease C1A family","Ace
tylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 2D6","Tyrosine protein kinase Syk family","Tyrosine protein kinase EGFR family","Cytochrome P450 1A1","CMGC protein kinase MAPK family","Cyt
ochrome P450 2C19","Tyrosine protein kinase PDGFR family","Cytochrome P450 2C9","Metallo protease M34 family","CMGC protein kinase ERK1","Tyrosine protein kinase Src family","Unclassified protein","Sh
ort peptide receptor (family A GPCR)","Neuropeptide receptor"}

> <pathway_chembl>
{Receptors,Enzymes,"G protein-coupled receptors","Eicosanoid turnover","Cytochrome P450","Catalytic receptors","Inositol phosphate turnover","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","3.2.1
.- Glycosidases","2.7.1.40 Pyruvate kinases","Glycoprotein hormone receptors",Lipoxygenases,"Acetylcholine receptors (muscarinic)","CYP3 family","CYP2 family: drug metabolising subset","Receptor kinas
es","CYP1 family","Inositol monophosphatase","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglandin synthases","1.14.11.- Histone demethylases","TK: Tyrosine kinase","Mitogen-activated protein
 kinases (MAP kinases)","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","ERK subfamily","Syk family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type III 
RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Src family","Neuropeptide S receptor"}

> <pathway_reactome>
{Disease,"Immune System",Metabolism,"Neuronal System","DNA Repair","Signal Transduction","Vesicle-mediated transport","Cellular responses to external stimuli","Gene expression (Transcription)","Develo
pmental Biology","Cell Cycle","Infectious disease","Cytokine Signaling in Immune system","Metabolism of amino acids and derivatives","Transmission across Chemical Synapses","Biological oxidations","DN
A Double-Strand Break Repair","Metabolism of lipids","Signaling by GPCR","Membrane Trafficking","Cellular responses to stress","Inositol phosphate metabolism","Innate Immune System","RNA Polymerase II
 Transcription","Nervous system development","Cell Cycle Checkpoints","Diseases of metabolism","Metabolism of carbohydrates","Leishmania infection","Signaling by Interleukins","Branched-chain amino ac
id catabolism","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization of compounds","Nonhomologous End-Joining (NHEJ)","Biosynthesis of specialized proresolving
 mediators (SPMs)","GPCR ligand binding","Gap junction trafficking and regulation","GPCR downstream signalling","Cellular response to hypoxia","Synthesis of IP2",IP,"and Ins in the cytosol","Toll-like
 Receptor Cascades","Generic Transcription Pathway","Axon guidance","G1/S DNA Damage Checkpoints","Homology Directed Repair","Diseases of carbohydrate metabolism","Glucose metabolism","Uptake and acti
ons of bacterial toxins","Sphingolipid metabolism","Leishmania parasite growth and survival","Interleukin-1 family signaling","Activation of NMDA receptors and postsynaptic events","Ethanol oxidation"
,"Biosynthesis of DPA-derived SPMs","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Gap junction trafficking","G alpha (q) sig
nalling events","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional Regulation by VENTX","Semaphorin interactions","p53-De
pendent G1/S DNA damage checkpoint","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Glycogen storage diseases",Glycolysis,"Uptake and function of anthrax toxins","Glycos
phingolipid metabolism","Anti-inflammatory response favouring Leishmania parasite infection","Interleukin-1 signaling","Post NMDA receptor activation events","Biosynthesis of DPAn-3 SPMs","Amine ligan
d-binding receptors","Biosynthesis of maresins",Xenobiotics,"Gap junction degradation","Gastrin-CREB signalling pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Biosynthesis of 
D-series resolvins","Sema4D in semaphorin signaling","p53-Dependent G1 DNA Damage Response","HDR through Homologous Recombination (HRR)","Glycogen storage disease type II (GAA)","ADORA2B mediated anti
-inflammatory cytokines production","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Activation of AMPK downstream of NMDARs","Biosynthesis of DPAn-3-derived protectins and resolvins","Muscarinic acetylc
holine receptors","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","FCGR3A-mediated IL10 synthesis","Formation of annular gap junctions","EGFR Transactivation by Gastrin","Biosynthesis of DPAn-3
-derived maresins","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP kinase activation","Sema4D induced cell migration and growth-cone collapse","Stabilization of p53","Homologou
s DNA Pairing and Strand Exchange","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","Presynaptic phase of homologous DNA pairing and strand exch
ange","ERK/MAPK targets","ERKs are inactivated","HIV Infection","Host Interactions of HIV factors","The role of Nef in HIV-1 replication and disease pathogenesis","Nef-mediates down modulation of cell
 surface receptors by recruiting them to clathrin adapters","Nef Mediated CD4 Down-regulation","Base Excision Repair","trans-Golgi Network Vesicle Budding","Resolution of Abasic Sites (AP sites)","EGR
2 and SOX10-mediated initiation of Schwann cell myelination","Golgi Associated Vesicle Biogenesis","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","PCNA-Dependent Long P
atch Base Excision Repair"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{"Tyrphostin A46","Tyrphostin 46","AG 99",122520-85-8,122520858,"122520 85 8","Tyrphostin B40",AG-99,AG99,"alpha-Cyano-(3,4-dihydroxy)cinnamide","alphaCyano(3,4dihydroxy)cinnamide","alpha Cyano (3,4 d
ihydroxy)cinnamide","Tyrphostin AG 99",EI-257,"TYRPHOSTIN 46"}

> <pdid>
PD014847

> <targets>
{EGFRK}

> <classes>
{}

> <pubchem_cids>
{5328768}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 23  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7554    0.0000 C   0  0
   -3.8938   -2.2554    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -5.2029    2.9932    0.0000 O   0  0
   -6.4990    0.7409    0.0000 N   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0990    0.7364    0.0000 C   0  0
  -10.4007    1.4818    0.0000 C   0  0
  -11.6971    0.7273    0.0000 C   0  0
  -11.6919   -0.7727    0.0000 C   0  0
  -10.3903   -1.5182    0.0000 C   0  0
   -9.0939   -0.7637    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  5  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  3  0
 10 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28089

> <plate>
Kinase v5-1

> <well>
A07

> <supplier_cmpd_name>
AG-490

> <ctcr_id>
7554

> <supplier_cmpd_id>
EI-272

> <smiles>
Oc1ccc(cc1O)\C=C(C#N)\C(=O)NCc2ccccc2

> <pd_targets>
{HIF1A,FFP,TP53,EGFR,KDM4E,SMN1,LMNA,MAPT,CYP2C19,ALOX15,CYP1A2,ALOX12,CHRM1,CYP3A4,GMNN,ERBB2,GRIN1,GRIN2B,GRIN2C,HSD17B10,FTL,KMT2A,MEN1,RECQL,BLM,JAK1,NFKB1,JAK3,PMP22,MAPK1,THPO,ALDH1A1,PKM,HPGD,L
EF,GRIN2A,MTOR,MAP4K2,PLK3,MKNK2,EEF2K,PRKD2,HIPK4,MINK1,MARK2,MAPKAPK2,PIM1,GSK3B,SLK,MAP4K5,PLK4,PRKAA1,TAOK1,IRAK1,AURKB,MAP3K20,AXL,GSK3A,PLK1}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator","Other nuclear protein","Other cytosolic protein","Membrane receptor","Unclassified protein","Ion channel",Transferase,Kinase,Eraser,Reader,"Cytoc
hrome P450",Oxidoreductase,"Family A G protein-coupled receptor","Ligand-gated ion channel",Protease,"Protein Kinase","Lysine demethylase","Methyl-lysine/arginine binding protein","Cytochrome P450 fam
ily 2","Cytochrome P450 family 1","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Ionotropic glutamate receptor",Bromodomain,"Metallo protease","TK protein kinase group","Jumonji
 domain-containing","Tudor domain","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Monoamine receptor","Cytochrome P450 family 3A","NMDA receptor","CMGC protein kinase group","Metallo proteas
e MAE clan","Atypical protein kinase group","Tyrosine protein kinase EGFR family","Cytochrome P450 2C19","Cytochrome P450 1A1","Acetylcholine receptor","Cytochrome P450 3A4","Tyrosine protein kinase J
akA family","CMGC protein kinase MAPK family","Metallo protease M34 family","Atypical protein kinase PIKK family","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","STE protein kinas
e group","Other protein kinase group","CAMK protein kinase group","TKL protein kinase group","STE protein kinase STE20 family","Other protein kinase PLK family","CAMK protein kinase MAPKAPK family","A
typical protein kinase alpha family","CAMK protein kinase PKD family","CMGC protein kinase DYRK family","CAMK protein kinase CAMK1 family","CAMK protein kinase PIM family","CMGC protein kinase GSK fam
ily","TKL protein kinase IRAK family","Other protein kinase AUR family","TKL protein kinase MLK family","Tyrosine protein kinase Axl family","STE protein kinase KHS subfamily","CAMK protein kinase MNK
 subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MARK subfamily","CAMK protein kinase MAPKAPK subfamily","STE protein kinase SLK subfamily","CAM
K protein kinase AMPK subfamily","STE protein kinase TAO subfamily","TKL protein kinase MLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Chromatin modifying enzymes","Cytochrome P450","Eicosanoid turnover","G protein-coupled receptors","Kinases (EC 2.7.x.x)","2.7.1.40 Pyruvate kinases","Recepto
r kinases","1.14.11.- Histone demethylases","CYP2 family: drug metabolising subset",Lipoxygenases,"CYP1 family","Acetylcholine receptors (muscarinic)","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"C
LK families","Prostaglandin synthases",Atypical,"TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Receptor tyrosi
ne kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","FRAP subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Janus kinase (JakA) family","STE: Homologs of
 yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE20 family","Other protein kinases","MAPK-Activated Protein Kinase (MAPKAPK) family","Alpha 
kinase family","Protein kinase D (PKD) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CAMK-like (CAMKL) family","PIM family","Glycogen synthase kinase (GSK) fa
mily","TKL: Tyrosine kinase-like","KHS subfamily","Polo-like kinase (PLK) family","MKN subfamily","eEF2K subfamily","HIPK subfamily","MSN subfamily","MARK subfamily","MAPKAPK subfamily","GSK subfamily
","SLK subfamily","AMPK subfamily","TAO subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","Aurora kinase (Aur) family","Mixed Lineage Kinase (MLK) family","MLK subfamily","Type XI RT
Ks: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{"Cellular responses to external stimuli","Cell Cycle","Signal Transduction","Metabolism of RNA","Neuronal System",Metabolism,"Developmental Biology","Vesicle-mediated transport","DNA Repair","Immune 
System",Hemostasis,Disease,"Gene expression (Transcription)","Cellular responses to stress","Cell Cycle Checkpoints","Signaling by GPCR","Metabolism of non-coding RNA",Mitotic,"Transmission across Che
mical Synapses","Biological oxidations","Metabolism of lipids","Nervous system development","Metabolism of amino acids and derivatives","Membrane Trafficking","DNA Double-Strand Break Repair","Cytokin
e Signaling in Immune system","Innate Immune System","Platelet activation","signaling and aggregation","Metabolism of carbohydrates","Infectious disease","RNA Polymerase II Transcription","Cellular re
sponse to hypoxia","G1/S DNA Damage Checkpoints","GPCR downstream signalling","snRNP Assembly","M Phase","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization 
of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","GPCR ligand binding","Mitotic G1 phase and G1/S transition","Axon guidance","Branched-chain amino acid catabolism","trans-Gol
gi Network Vesicle Budding","Homology Directed Repair","Interferon Signaling","Signaling by Interleukins","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Toll-like Receptor Cascades"
,"Platelet Aggregation (Plug Formation)","Glucose metabolism","Uptake and actions of bacterial toxins","Generic Transcription Pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Fact
or Alpha","p53-Dependent G1/S DNA damage checkpoint","G alpha (q) signalling events","Mitotic Metaphase and Anaphase","Activation of NMDA receptors and postsynaptic events","Cytochrome P450 - arranged
 by substrate type","Biosynthesis of DPA-derived SPMs","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","G1/S Transition","Semaphorin interactions","Golgi Associated Vesicle B
iogenesis","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Antiviral mechanism by IFN-stimulated genes","Interleukin-1 family signaling","Interleukin-2 family signaling"
,"Toll Like Receptor 5 (TLR5) Cascade","Ethanol oxidation",Glycolysis,"Uptake and function of anthrax toxins","Transcriptional Regulation by TP53","p53-Dependent G1 DNA Damage Response","Gastrin-CREB 
signalling pathway via PKC and MAPK","Mitotic Anaphase","Post NMDA receptor activation events",Xenobiotics,"Biosynthesis of DPAn-3 SPMs","Amine ligand-binding receptors","Biosynthesis of maresins","Ac
tivation of the pre-replicative complex","Sema4D in semaphorin signaling","HDR through Homologous Recombination (HRR)","ISG15 antiviral mechanism","Interleukin-1 signaling","Interleukin-15 signaling",
"MyD88 cascade initiated on plasma membrane","Biosynthesis of D-series resolvins","Regulation of TP53 Activity","Stabilization of p53","EGFR Transactivation by Gastrin","Nuclear Envelope (NE) Reassemb
ly","Activation of AMPK downstream of NMDARs","CYP2E1 reactions","Biosynthesis of DPAn-3-derived protectins and resolvins","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthe
sis of DPAn-3-derived maresins","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","Sema4D induced cell migration and growth-cone collapse","Homologous DNA Pairing and Strand Exc
hange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","MAP kinase activation","Regulation of TP53 Expression and Degradation","Autodegradation of the E3 ubiquitin ligase COP1","Initiation of Nuclear Env
elope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","ERK/MAPK targets","ER
Ks are inactivated","MTOR signalling","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","mTORC1-mediated signalling","Sphingol
ipid metabolism","Cellular Senescence","FLT3 signaling in disease","SARS-CoV Infections","Mitotic G2-G2/M phases","Signaling by VEGF","Sphingolipid de novo biosynthesis","Oxidative Stress Induced Sene
scence","Signaling by FLT3 ITD and TKD mutants","SARS-CoV-1 Infection","G2/M Transition","VEGFA-VEGFR2 Pathway","STAT5 activation downstream of FLT3 ITD mutants","SARS-CoV-1 Genome Replication and Tra
nscription","Centrosome maturation","Regulation of TP53 Activity through Phosphorylation","Replication of the SARS-CoV-1 genome","Loss of proteins required for interphase microtubule organization from
 the centrosome","Separation of Sister Chromatids","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK activation","CREB phosphorylation"}

> <broad_targets>
{EGFR,JAK2,JAK3}

> <broad_moa>
{"EGFR inhibitor","JAK inhibitor"}

> <synonyms>
{"G490 (TYRPHOSTIN B42",133550-30-8,133550308,AG-490,AG490,"Tyrphostin B42","AG 490","Tyrphostin AG 490","(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide","(E)Nbenzyl2cyano3(3,4dihydroxyphenyl)
acrylamide","Tyrphostin AG490","tyrphostin AG-490","tyrphostin AG490","AG-490 (Tyrphostin B42)","AG490 (Tyrphostin B42)",alpha-Cyano-(3,alphaCyano(3,4-dihydroxy)-N-benzy,4dihydroxy)Nbenzy,T2600,"EMD 6
58401",EI-272,414,S1143,658401}

> <pdid>
PD002602

> <targets>
{EGFR,JAK}

> <classes>
{}

> <pubchem_cids>
{5328779}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6924   -4.0811    0.0000 I   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.8813   -1.4408    0.0000 C   0  0
   -4.8896   -2.5354    0.0000 O   0  0
   -6.2433   -1.8893    0.0000 C   0  0
   -7.5587   -2.6066    0.0000 C   0  0
   -7.5961   -4.1061    0.0000 O   0  0
   -6.0471   -0.4022    0.0000 C   0  0
   -7.1349    0.6307    0.0000 O   0  0
   -4.5721   -0.1292    0.0000 C   0  0
   -3.9177    1.2205    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
  9 11  1  0
 11  2  1  0
 11  6  2  0
  7 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 14 17  1  0
 17 18  1  0
 17 19  1  0
 19 12  1  0
 19 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28091

> <plate>
Kinase v5-1

> <well>
A11

> <supplier_cmpd_name>
5-Iodotubericidin

> <ctcr_id>
1431

> <supplier_cmpd_id>
EI-293

> <smiles>
Nc1ncnc2n(cc(I)c12)C3OC(CO)C(O)C3O

> <pd_targets>
{ADK,MAPK1,ADOK,DOT1L}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Transferase,Kinase,Writer,"Protein Kinase","Protein methyltransferase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,"Adenosine turnover","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","CMGC: Containing CDK",MAPK,GSK3,"CLK families","2.1.1.43 Histone methyltransferases (HMTs)","Mitogen-activated prote
in kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Immune System","Chromatin organization","Metabolism of nucleotides","Innate Immune System","Chromatin modifying enzymes","Nucleotide salvage","Toll-like Receptor Cascades","PKMTs methylat
e histone lysines","Purine salvage","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","E
RK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{IODOTUBERICIDI,7-Deaza-7-iodoadenosine,7Deaza7iodoadenosine,BiomolKI_000049,BiomolKI000049,BiomolKI-000049,"BiomolKI 000049",BiomolKI2_000055,BiomolKI2000055,BiomolKI2-000055,"BiomolKI2 000055",BMK1-
F1,BMK1F1,BSPBio_001227,BSPBio001227,BSPBio-001227,"BSPBio 001227",KBioGR_000567,KBioGR000567,KBioGR-000567,"KBioGR 000567",KBioSS_000567,KBioSS000567,KBioSS-000567,"KBioSS 000567",CHEMBL63388,SCHEMBL
2043545,CHEBI:93817,KBio2_000567,KBio2000567,KBio2-000567,"KBio2 000567",KBio2_003135,KBio2003135,KBio2-003135,"KBio2 003135",KBio2_005703,KBio2005703,KBio2-005703,"KBio2 005703",KBio3_001013,KBio3001
013,KBio3-001013,"KBio3 001013",KBio3_001014,KBio3001014,KBio3-001014,"KBio3 001014",Bio2_000444,Bio2000444,Bio2-000444,"Bio2 000444",Bio2_000924,Bio2000924,Bio2-000924,"Bio2 000924",HM,T6745,"EMD 407
900",EI-293,5-Iodotubercidin,407900,5-Iodotubericidin}

> <pdid>
PD005972

> <targets>
{5-Iodotubercidin,ERK2,CK2,CK1,"adenosine kinase"}

> <classes>
{}

> <pubchem_cids>
{1830}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 14  0  0  0  0            999 V2000
    7.7996   -1.4883    0.0000 C   0  0
    6.4990   -0.7409    0.0000 O   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2029   -2.9932    0.0000 O   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
  9 11  2  0
 11 12  1  0
 12 13  2  0
 13  7  1  0
 13 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28092

> <plate>
Kinase v5-1

> <well>
A13

> <supplier_cmpd_name>
Erbstatin analog

> <ctcr_id>
7665

> <supplier_cmpd_id>
EI-146

> <smiles>
COC(=O)/C=C/c1cc(O)ccc1O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor","tyrosine kinase inhibitor"}

> <synonyms>
{5-DIHYDROXYCINNAMAT,5DIHYDROXYCINNAMAT,"Methyl 2,5-dihydroxycinnamate","Methyl 2,5dihydroxycinnamate",63177-57-1,63177571,"erbstatin analog","2,5-Dihydroxycinnamic acid methyl ester","2,5Dihydroxycin
namic acid methyl ester","methyl 3-(2,5-dihydroxyphenyl)acrylate","methyl 3(2,5dihydroxyphenyl)acrylate","(E)-methyl 3-(2,5-dihydroxyphenyl)acrylate","(E)methyl 3(2,5dihydroxyphenyl)acrylate","methyl 
(E)-3-(2","methyl (E)3(2",5-dihydroxypheny,5dihydroxypheny,EI-146,"Erbstatin analog"}

> <pdid>
PD019584

> <targets>
{EGFRK}

> <classes>
{}

> <pubchem_cids>
{5353609}

$$$$
UTKinase_V5
  SciTegic11012413002D

 11 12  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5926    0.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  3  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9  7  1  0
  9 10  1  0
 10  2  1  0
 10 11  2  0
M  END
> <name>
UTKinase_V5

> <id>
28093

> <plate>
Kinase v5-1

> <well>
A15

> <supplier_cmpd_name>
Terreic acid

> <ctcr_id>
5729

> <supplier_cmpd_id>
EI-328

> <smiles>
CC1=C(O)C(=O)C2OC2C1=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Terreic acid (6CI)",SCHEMBL51230,"4-hydroxy-3-methyl-7-oxabicyclo(4.1.0)hept-3-ene-2,5-dione","4hydroxy3methyl7oxabicyclo(4.1.0)hept3ene2,5dione",J3.570.099D,J-004490,J004490,"2-Methyl-3-hydroxy-5,6
-epoxy-2-cyclohexene-1,4-dione","2Methyl3hydroxy5,6epoxy2cyclohexene1,4dione","5,6-epoxy-2-hydroxy-3-methyl-2-cyclo-hexene-1,4-dione","5,6epoxy2hydroxy3methyl2cyclohexene1,4dione",1405,EI-328,"(-)-Ter
reic acid","Terreic acid"}

> <pdid>
PD021907

> <targets>
{BTK}

> <classes>
{}

> <pubchem_cids>
{4561942}

$$$$
UTKinase_V5
  SciTegic11012413002D

 15 15  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -1.3101    6.7502    0.0000 N   0  0
   -2.6024    2.9967    0.0000 C   0  0
   -3.9001    2.2444    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  2  1  0
  8  9  1  0
  4 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  3  0
 11 14  1  0
 14 15  3  0
M  END
> <name>
UTKinase_V5

> <id>
28094

> <plate>
Kinase v5-1

> <well>
A17

> <supplier_cmpd_name>
TYRPHOSTIN 25

> <ctcr_id>
5113

> <supplier_cmpd_id>
EI-187

> <smiles>
Oc1cc(cc(O)c1O)C=C(C#N)C#N

> <pd_targets>
{HSD17B10,HIF1A,PMP22,THPO,CYP3A4,LCK,KMT2A,MEN1,NFKB1,USP2,HPGD,TP53,CYP2C9,KDM4E,ALDH1A1,FFP,EGFR,LMNA,LUXP,MAPT,NPSR1,ALOX12,BLM,CHRM1,TSHR,ALD,ALOX15,RORC}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Unclassified protein","Epigenetic regulator","Other cytosolic protein","Other nuclear protein","Membrane receptor",Oxidoreductase,"Cytochrome P450",Kinase,Reader,Protea
se,Eraser,Transferase,"Family A G protein-coupled receptor","Nuclear receptor","Cytochrome P450 family 3","Protein Kinase",Bromodomain,"Cysteine protease","Cytochrome P450 family 2","Lysine demethylas
e","Peptide receptor (family A GPCR)","Small molecule receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3A","TK protein kinase group","Cysteine protease CA clan"
,"Cytochrome P450 family 2C","Jumonji domain-containing","Short peptide receptor (family A GPCR)","Monoamine receptor","Glycohormone receptor","Nuclear hormone receptor subfamily 1 group F","Cytochrom
e P450 3A4","Tyrosine protein kinase Src family","Cysteine protease C19 family","Cytochrome P450 2C9","Tyrosine protein kinase EGFR family","Neuropeptide receptor","Acetylcholine receptor","Nuclear ho
rmone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Catalytic receptors","Peptidases and proteinases","Eicosanoid turnover","Chromatin modifying enzymes","G protein-coupled receptors","Nuclear hormone receptors","C
YP3 family","Receptor kinases","CA: Cysteine (C) Peptidases","Prostaglandin synthases","CYP2 family: drug metabolising subset","1.14.11.- Histone demethylases","Neuropeptide S receptor",Lipoxygenases,
"Acetylcholine receptors (muscarinic)","Glycoprotein hormone receptors","1F. Retinoic acid-related orphans","TK: Tyrosine kinase","C19: Ubiquitin-specific protease","Non-receptor tyrosine kinases (nRT
Ks)","Receptor tyrosine kinases (RTKs)","Src family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{Metabolism,"Cellular responses to external stimuli","Developmental Biology",Hemostasis,Disease,"Immune System","Gene expression (Transcription)","Cell Cycle","Signal Transduction","Neuronal System","
DNA Repair","Metabolism of amino acids and derivatives","Cellular responses to stress","Nervous system development","Platelet activation","signaling and aggregation","Metabolism of lipids","Infectious
 disease","Cytokine Signaling in Immune system","RNA Polymerase II Transcription","Cell Cycle Checkpoints","Biological oxidations","Signaling by GPCR",Mitotic,"Transmission across Chemical Synapses","
DNA Double-Strand Break Repair","Branched-chain amino acid catabolism","Cellular response to hypoxia","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Platelet Aggregation (Plug Forma
tion)","Biosynthesis of specialized proresolving mediators (SPMs)","HIV Infection","Signaling by Interleukins","Generic Transcription Pathway","G1/S DNA Damage Checkpoints","Phase I - Functionalizatio
n of compounds","GPCR downstream signalling","M Phase","Neurotransmitter receptors and postsynaptic signal transmission","Leishmania infection","Homology Directed Repair","GPCR ligand binding","Oxygen
-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Biosynthesis of DHA-derived SPMs","Host Interactions of HIV factors","Interleukin-1 family signaling","Transcriptional Regulation b
y TP53","p53-Dependent G1/S DNA damage checkpoint","Cytochrome P450 - arranged by substrate type","Ethanol oxidation","G alpha (q) signalling events","Mitotic Metaphase and Anaphase","Activation of NM
DA receptors and postsynaptic events","Leishmania parasite growth and survival","Biosynthesis of DPA-derived SPMs","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Class 
A/1 (Rhodopsin-like receptors)","Transcriptional regulation by RUNX3","Biosynthesis of maresins","The role of Nef in HIV-1 replication and disease pathogenesis","Interleukin-1 signaling","Regulation o
f TP53 Activity","Biosynthesis of D-series resolvins","p53-Dependent G1 DNA Damage Response",Xenobiotics,"Gastrin-CREB signalling pathway via PKC and MAPK","Mitotic Anaphase","Post NMDA receptor activ
ation events","Anti-inflammatory response favouring Leishmania parasite infection","Biosynthesis of DPAn-3 SPMs","HDR through Homologous Recombination (HRR)","Amine ligand-binding receptors","RUNX3 Re
gulates Immune Response and Cell Migration","Biosynthesis of maresin-like SPMs","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","MAP3K8 (TPL2)-dependen
t MAPK1/3 activation","Regulation of TP53 Expression and Degradation","Stabilization of p53","CYP2E1 reactions","EGFR Transactivation by Gastrin","Nuclear Envelope (NE) Reassembly","Activation of AMPK
 downstream of NMDARs","ADORA2B mediated anti-inflammatory cytokines production","Biosynthesis of DPAn-3-derived maresins","Homologous DNA Pairing and Strand Exchange","Muscarinic acetylcholine recept
ors","Biosynthesis of DPAn-3-derived protectins and resolvins","Nef Mediated CD4 Down-regulation","Regulation of TP53 Degradation","Autodegradation of the E3 ubiquitin ligase COP1","Initiation of Nucl
ear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Tyrphostin A25","Tyrphostin 25",118409-58-8,118409588,Tyrphostin-25,Tyrphostin25,"2-((3,4,5-trihydroxyphenyl)methylidene)propanedinitrile","2((3,4,5trihydroxyphenyl)methylidene)propanedinitrile","2-
(3,4,5-Trihydroxybenzylidene)malononitrile","2(3,4,5Trihydroxybenzylidene)malononitrile","alpha-Cyano-(3,4,5-trihydroxy)cinnamonitrile","alphaCyano(3,4,5trihydroxy)cinnamonitrile",AG-82,AG82,NSC676484
,NCGC00016046,EI-187,"TYRPHOSTIN 25"}

> <pdid>
PD014977

> <targets>
{EGFRK}

> <classes>
{}

> <pubchem_cids>
{2061}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
   -3.9477   -7.1844    0.0000 C   0  0
   -2.8628   -6.1485    0.0000 C   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 C   0  0
   -3.2175   -4.6910    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8788   -1.4412    0.0000 C   0  0
    4.8834   -2.5550    0.0000 C   0  0
    4.3416   -0.0143    0.0000 C   0  0
    5.3458   -1.1283    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17  8  1  0
 17 11  1  0
 10 18  1  0
 18 19  1  0
 18 20  1  0
 18 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28095

> <plate>
Kinase v5-1

> <well>
A19

> <supplier_cmpd_name>
PP1

> <ctcr_id>
4913

> <supplier_cmpd_id>
EI-275

> <smiles>
Cc1ccc(cc1)c2nn(c3ncnc(N)c23)C(C)(C)C

> <pd_targets>
{PDGFRA,CSNK1D,CSK,CDC42BPA,FLT3,ABL1,BLK,EPHA2,CLK4,SRC,NTRK3,FRK,LIMK1,KIT,INSR,EGFR,KDR,FYN,PRKACA,RPS6KB1,MTOR,LCK,MAPK9,KDM4E,AMPC,RET,CLK2,MAP3K20,LYN,BTK,NTRK2,FGFR3,HTT,RORC,CSNK1A1,MARK2,FLT1
,ERBB4,TEK,ROCK2,WNK1,RPS6KA3,PLK4,RIPK2,CSF1R,AKT3,ERBB2,PRKD3,SLK,YES1,AURKB,LMNA,TAOK1,SRMS,PTK6,FLT4,HPGD,RPL19A,PRKD2,ROCK1,MAPK14,STK3,ALDH1A1,MAP4K4,IRAK4,FGFR1,ROS1}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Unclassified protein","Transcription factor","Other nuclear protein",Kinase,Eraser,Hydrolase,"Nuclear receptor",Oxidoreductase,"Protein Kinase","Lysine demethylase","Nu
clear hormone receptor subfamily 1","TK protein kinase group","CK1 protein kinase group","AGC protein kinase group","CMGC protein kinase group","TKL protein kinase group","Atypical protein kinase grou
p","Jumonji domain-containing","Nuclear hormone receptor subfamily 1 group F","CAMK protein kinase group","Other protein kinase group","STE protein kinase group","Tyrosine protein kinase PDGFR family"
,"CK1 protein kinase CK1 family","Tyrosine protein kinase Csk family","AGC protein kinase DMPK family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Src family","Tyrosine protein kinas
e Eph family","CMGC protein kinase CLK family","Tyrosine protein kinase Trk family","TKL protein kinase LISK family","Tyrosine protein kinase InsR family","Tyrosine protein kinase EGFR family","Tyrosi
ne protein kinase VEGFR family","AGC protein kinase PKA family","AGC protein kinase RSK family","Atypical protein kinase PIKK family","CMGC protein kinase MAPK family","Tyrosine protein kinase Ret fam
ily","TKL protein kinase MLK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase FGFR family","Nuclear hormone receptor subfamily 1 group F member 3","CAMK protein kinase CAMK1 famil
y","Tyrosine protein kinase Tie family","Other protein kinase Wnk family","Other protein kinase PLK family","TKL protein kinase RIPK family","AGC protein kinase AKT family","CAMK protein kinase PKD fa
mily","STE protein kinase STE20 family","Other protein kinase AUR family","TKL protein kinase IRAK family","Tyrosine protein kinase Sev family","AGC protein kinase GEK subfamily","TKL protein kinase L
IMK subfamily","Tyrosine protein kinase SrcA","AGC protein kinase p70 subfamily","Atypical protein kinase FRAP subfamily","CMGC protein kinase JNK subfamily","TKL protein kinase MLK subfamily","CAMK p
rotein kinase MARK subfamily","AGC protein kinase ROCK subfamily","AGC protein kinase RSK subfamily","STE protein kinase SLK subfamily","STE protein kinase TAO subfamily","Tyrosine protein kinase Srm"
,"CMGC protein kinase p38 subfamily","STE protein kinase MST subfamily","STE protein kinase MSN subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Nuclear hormone receptors","Eicosanoid turnover","Receptor kinases","CK1: Casein kinase 1","AGC: Containi
ng PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"1.14.11.- Histone demethylases","1F. Retinoic acid-related orphans","CAMK: Calcium/calmodulin-dependent protein kin
ases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Prostaglandin synthases","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","DMPK family","CLK family","TKL: Tyrosine kina
se-like","Protein kinase A (PKA) family","RSK family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Mitogen-activated protein kinases (MAP kinases)","CAMK-like (CAMKL) family","Othe
r protein kinases","Akt (Protein kinase B","PKB) family","Protein kinase D (PKD) family","STE20 family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","GEK subfamily","LIM 
domain kinase (LISK) family","p70 subfamily","FRAP subfamily","JNK subfamily","Mixed Lineage Kinase (MLK) family","MARK subfamily","Rho kinase","Wnk family","RSK subfamily","Polo-like kinase (PLK) fam
ily","Receptor interacting protein kinase (RIPK) family","SLK subfamily","Aurora kinase (Aur) family","TAO subfamily","p38 subfamily","MST subfamily","MSN subfamily","Interleukin-1 receptor-associated
 kinase (IRAK) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Csk family","Abl family","Src family","Type XIII RTKs: Ephrin receptor family","Type VII RTKs: Neurotrophin receptor/Trk 
family","LIMK subfamily","Type II RTKs: Insulin receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"
,"Type XIV RTKs: RET","MLK subfamily","Tec family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Type XVII RTKs: ROS receptors"}

> <pathway_reactome>
{Disease,"Cell Cycle","Signal Transduction","Gene expression (Transcription)","Developmental Biology","Immune System","Neuronal System","Transport of small molecules",Metabolism,"Cellular responses to
 external stimuli","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Signaling by Receptor Tyrosine Kinases","Infectious disease","RNA Polymerase II Transcrip
tion","Nervous system development","Intracellular signaling by second messengers","Signaling by GPCR","MTOR signalling","Innate Immune System","Transmission across Chemical Synapses","MAPK family sign
aling cascades","Ion channel transport","Metabolism of lipids","Signaling by Non-Receptor Tyrosine Kinases","Signaling by Hippo","Biological oxidations","Cellular responses to stress","Signaling by PD
GFR in disease","Mitotic G2-G2/M phases","Oncogenic MAPK signaling","Signaling by Insulin receptor","Leishmania infection","Generic Transcription Pathway","Axon guidance","Signaling by NTRKs","PIP3 ac
tivates AKT signaling","Signaling by KIT in disease","GPCR downstream signalling","Signaling by VEGF","HIV Infection","mTORC1-mediated signalling","Toll-like Receptor Cascades","Signaling by FGFR in d
isease","Signaling by WNT in cancer","Neurotransmitter receptors and postsynaptic signal transmission","MAPK1/MAPK3 signaling","Stimuli-sensing channels","Sphingolipid metabolism","M Phase","Signaling
 by PTK6","Mitotic G1 phase and G1/S transition","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","Cellular Senescence","Drug resistance of PDGFR 
mutants","G2/M Transition","Signaling by RAS mutants","Insulin receptor signalling cascade","Parasite infection","Transcriptional regulation by RUNX1","EPH-Ephrin signaling","Signaling by NTRK1 (TRKA)
","Signaling by NTRK3 (TRKC)","PTEN Regulation","Semaphorin interactions","Drug resistance of KIT mutants","Negative regulation of the PI3K/AKT network","G alpha (q) signalling events","VEGFA-VEGFR2 P
athway","Host Interactions of HIV factors","Transcriptional Regulation by TP53","Toll Like Receptor 5 (TLR5) Cascade","RET signaling","Leishmania parasite growth and survival","Signaling by FGFR3 in d
isease","Transcriptional Regulation by MECP2","Transcriptional regulation by RUNX3","Signaling by AMER1 mutants","VEGF ligand-receptor interactions","Activation of NMDA receptors and postsynaptic even
ts","RAF/MAP kinase cascade","Transcriptional Regulation by VENTX","Sphingolipid de novo biosynthesis","Mitotic Metaphase and Anaphase","PTK6 Down-Regulation","G1 Phase","Biosynthesis of DHA-derived S
PMs","Ethanol oxidation","Oxidative Stress Induced Senescence","Toll Like Receptor 2 (TLR2) Cascade","Signaling by FGFR1 in disease","Imatinib-resistant PDGFR mutants","Centrosome maturation","Signali
ng downstream of RAS mutants","IRS-mediated signalling","Leishmania phagocytosis","RUNX1 regulates transcription of genes involved in BCR signaling","EPHA-mediated growth cone collapse","Signalling to
 ERKs","Activated NTRK3 signals through PI3K","Regulation of PTEN stability and activity","Sema4D in semaphorin signaling","Dasatinib-resistant KIT mutants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signa
ling","Gastrin-CREB signalling pathway via PKC and MAPK","VEGFR2 mediated cell proliferation","The role of Nef in HIV-1 replication and disease pathogenesis","Regulation of TP53 Activity","MyD88 casca
de initiated on plasma membrane","Anti-inflammatory response favouring Leishmania parasite infection","Activation of TRKA receptors","Signaling by FGFR3 point mutants in cancer","Regulation of MECP2 e
xpression and activity","RUNX3 Regulates Immune Response and Cell Migration","Truncations of AMER1 destabilize the destruction complex","VEGF binds to VEGFR leading to receptor dimerization","Post NMD
A receptor activation events","Mitotic Anaphase","Cyclin D associated events in G1","Biosynthesis of D-series resolvins","Toll Like Receptor TLR6:TLR2 Cascade","FGFR1 mutant receptor activation","Loss
 of proteins required for interphase microtubule organization from the centrosome","PI3K Cascade","FCGR3A-mediated phagocytosis","Signalling to RAS","Sema4D induced cell migration and growth-cone coll
apse","EGFR Transactivation by Gastrin","Nef and signal transduction","Regulation of TP53 Expression and Degradation","Nef-mediates down modulation of cell surface receptors by recruiting them to clat
hrin adapters","MAP kinase activation","FCGR3A-mediated IL10 synthesis","NGF-independant TRKA activation","FGFR3 mutant receptor activation","Long-term potentiation","Separation of Sister Chromatids",
"Nuclear Envelope (NE) Reassembly","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Signaling by activated point mutants of FGFR1","Loss of Nlp from mitotic centrosomes","p38MAPK events","Regu
lation of TP53 Degradation","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","Signaling by activated point mutants of FGFR3","activated TAK1 mediates p38 MAPK 
activation","Initiation of Nuclear Envelope (NE) Reformation","Activation of the AP-1 family of transcription factors","CREB phosphorylation"}

> <broad_targets>
{HCK,RET}

> <broad_moa>
{"SRC inhibitor"}

> <synonyms>
{172889-26-8,172889268,PP1,"PP 1","1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1(tertButyl)3(ptolyl)1Hpyrazolo(3,4d)pyrimidin4amine","1-tert-butyl-3-(4-methylphenyl)-1h-pyrazolo(3
,4-d)pyrimidin-4-amine","1tertbutyl3(4methylphenyl)1hpyrazolo(3,4d)pyrimidin4amine","1-ter-butyl-3-p-tolyl-1h-pyrazolo(3,4-d)pyrimidin-4-ylamine","1terbutyl3ptolyl1hpyrazolo(3,4d)pyrimidin4ylamine",CH
EMBL306380,1-tert-butyl-3-,1tertbutyl3,T6196,1397,EI-275,S7060}

> <pdid>
PD008408

> <targets>
{Src,"Src family",Apoptosis}

> <classes>
{Angiogenesis,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{1400}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    9.0983   -0.7529    0.0000 C   0  0
    7.7988   -1.5020    0.0000 N   0  0
    6.4990   -0.7516    0.0000 C   0  0
    5.1988   -1.5012    0.0000 C   0  0
    3.8990   -0.7508    0.0000 N   0  0
    2.5988   -1.5004    0.0000 S   0  0
    2.5983   -3.0004    0.0000 O   0  0
    3.8975   -2.2510    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  2  0
  6  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  9  1  0
 18 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28096

> <plate>
Kinase v5-1

> <well>
A21

> <supplier_cmpd_name>
H-8

> <ctcr_id>
1599

> <supplier_cmpd_id>
EI-158

> <smiles>
CNCCN[S](=O)(=O)c1cccc2cnccc12

> <pd_targets>
{PRKACA,LMNA,PMP22,PFMRK,CYP3A4,GLA,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,NFKB1,CYP2D6,LEF,AKT2,MYLK,CNGA1}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein","Unclassified protein","Other cytosolic protein","Ion channel",Kinase,"Cytochrome P450",Hydrolase,Protease,"Voltage-gated ion channel","Protein Kinase","Cytochrome P450
 family 3","Cytochrome P450 family 2","Metallo protease","Cyclic nucleotide-regulated channel","AGC protein kinase group","CMGC protein kinase group","Cytochrome P450 family 3A","Cytochrome P450 famil
y 2D","Metallo protease MAE clan","CAMK protein kinase group","AGC protein kinase PKA family","CMGC protein kinase CDK family","Cytochrome P450 3A4","AGC protein kinase PKC family","Cytochrome P450 2D
6","Metallo protease M34 family","AGC protein kinase AKT family","CAMK protein kinase MLCK family","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels","Kinases (EC 2.7.x.x)","Cytochrome P450","Voltage-gated ion channels","AGC: Containing PKA",PKG,"PKC families","CYP3 family","CYP2 family: drug metabolising subset","CAMK: Calc
ium/calmodulin-dependent protein kinases","Cyclic nucleotide-regulated channels","Protein kinase A (PKA) family","Akt (Protein kinase B","PKB) family","Myosin Light Chain Kinase (MLCK) family"}

> <pathway_reactome>
{"Cell Cycle","Developmental Biology",Metabolism,"Immune System",Disease,"Signal Transduction",Mitotic,"Nervous system development","Metabolism of lipids","Cytokine Signaling in Immune system","Biolog
ical oxidations","Infectious disease","Signaling by Receptor Tyrosine Kinases","Signaling by Rho GTPases","Signaling by GPCR","Mitotic G2-G2/M phases","M Phase","EGR2 and SOX10-mediated initiation of 
Schwann cell myelination","Biosynthesis of specialized proresolving mediators (SPMs)","Sphingolipid metabolism","Signaling by Interleukins","Phase I - Functionalization of compounds","Uptake and actio
ns of bacterial toxins","Signaling by Insulin receptor","RHO GTPase Effectors","GPCR downstream signalling","G2/M Transition","Mitotic Metaphase and Anaphase","Biosynthesis of DHA-derived SPMs","Glyco
sphingolipid metabolism","Interleukin-1 family signaling","Cytochrome P450 - arranged by substrate type","Uptake and function of anthrax toxins","Insulin receptor signalling cascade","RHO GTPases acti
vate PAKs","G alpha (i) signalling events","Centrosome maturation","Mitotic Anaphase","Biosynthesis of maresins","Interleukin-1 signaling",Xenobiotics,"IRS-mediated signalling","Visual phototransducti
on","Loss of proteins required for interphase microtubule organization from the centrosome","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","MAP3K8 (TPL2)-dependent MAPK1/3 acti
vation","CYP2E1 reactions","PI3K Cascade","The phototransduction cascade","Loss of Nlp from mitotic centrosomes","Initiation of Nuclear Envelope (NE) Reformation","PKB-mediated events","Activation of 
the phototransduction cascade","PDE3B signalling"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{84478-11-5,84478115,N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide,N(2(Methylamino)ethyl)5isoquinolinesulfonamide,h-8,h8,N-(2-(methylamino)ethyl)isoquinoline-5-sulfonamide,N(2(methylamino)ethyl)i
soquinoline5sulfonamide,N-(2-(METHYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE,N(2(METHYLAMINO)ETHYL)5ISOQUINOLINESULFONAMIDE,(5-Isoquinolylsulfonyl)(2-(methylamino)ethyl)amine,(5Isoquinolylsulfonyl)(2(me
thylamino)ethyl)amine,Lopac-M-9656,LopacM9656,UNII-TX277E49WT,UNIITX277E49WT,CHE,EI-158,H-8}

> <pdid>
PD005267

> <targets>
{H-8,Dihydrochloride,PKA,PKG}

> <classes>
{}

> <pubchem_cids>
{3540}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  0  0            999 V2000
    3.8964    0.7545    0.0000 N   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2029   -2.9940    0.0000 C   0  0
    5.2056   -4.4940    0.0000 N   0  0
    6.4990   -0.7409    0.0000 C   0  0
    6.4964    0.7599    0.0000 C   0  0
    6.4938    2.2599    0.0000 N   0  0
    7.8003   -1.4887    0.0000 C   0  0
    7.8029   -2.9887    0.0000 N   0  0
    9.0990   -0.7364    0.0000 S   0  0
   10.4003   -1.4841    0.0000 C   0  0
   10.4004   -2.9842    0.0000 C   0  0
   11.6994   -3.7342    0.0000 C   0  0
   12.9985   -2.9841    0.0000 C   0  0
   12.9984   -1.4841    0.0000 C   0  0
   11.6994   -0.7342    0.0000 C   0  0
   11.6994    0.7658    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
  2 11  2  0
 11 12  1  0
 12 13  3  0
 11 14  1  0
 14 15  1  0
 15 16  3  0
 14 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 25 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28097

> <plate>
Kinase v5-1

> <well>
C03

> <supplier_cmpd_name>
U-0126

> <ctcr_id>
7667

> <supplier_cmpd_id>
EI-282

> <smiles>
N\C(Sc1ccccc1N)=C(C#N)/C(C#N)=C(\N)Sc2ccccc2N

> <pd_targets>
{MAP2K1,KMT2A,MEN1,MAPT,FTL,MAPK1,BLM,GMNN,GAA,LMNA,HPGD,NPSR1,ALDH1A1,MTOR,FFP,MAPKAPK5,BRAF,MAP2K2,MDH,MAPK14,AKT1,RAF1,CYP2C19,RORC,LEF,CHRM1,HSD17B10,EGFR,CYP2D6,CYP1A2,ALOX15,KDM4E,HIF1A,ALOX12,C
YP3A4,THPO}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Unclassified protein","Other nuclear protein","Membrane receptor",Kinase,Reader,Hydrolase,"Family A G protein-coupled receptor",Oxidoreductase
,Transferase,"Protein Kinase",Bromodomain,"Peptide receptor (family A GPCR)","STE protein kinase group","CMGC protein kinase group","Short peptide receptor (family A GPCR)","Atypical protein kinase gr
oup","CAMK protein kinase group","TKL protein kinase group","AGC protein kinase group","STE protein kinase STE7 family","CMGC protein kinase MAPK family","Neuropeptide receptor","Atypical protein kina
se PIKK family","CAMK protein kinase MAPKAPK family","TKL protein kinase RAF family","AGC protein kinase AKT family","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","CAMK protein k
inase MAPKAPK subfamily","CMGC protein kinase p38 subfamily","Transcription factor","Cytochrome P450","Nuclear receptor",Protease,Eraser,"Cytochrome P450 family 2","Nuclear hormone receptor subfamily 
1","Metallo protease","Small molecule receptor (family A GPCR)","Cytochrome P450 family 1","Lysine demethylase","Cytochrome P450 family 3","Cysteine protease","Cytochrome P450 family 2C","Nuclear horm
one receptor subfamily 1 group F","Metallo protease MAE clan","Monoamine receptor","TK protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Jumonji domain-containing","Cytoch
rome P450 family 3A","Cysteine protease CA clan","Cytochrome P450 2C19","Nuclear hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Acetylcholine receptor","Tyrosine protein
 kinase EGFR family","Cytochrome P450 2D6","Cytochrome P450 1A1","Cytochrome P450 3A4","Cysteine protease C1A family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","3.2.1.- Glycosidases","Eicosanoid turnover","G protein-coupled receptors","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 k
inases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglandin synthases","Neuropeptide S receptor",Atypical,"CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","AGC: Conta
ining PKA",PKG,"PKC families","STE7 family","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","MAPK-Activated Protein Kinase (MAPKAPK) f
amily","TKL: Tyrosine kinase-like","Akt (Protein kinase B","PKB) family","ERK subfamily","FRAP subfamily","MAPKAPK subfamily","RAF family","p38 subfamily","Cytochrome P450","Nuclear hormone receptors"
,"Chromatin modifying enzymes","CYP2 family: drug metabolising subset","1F. Retinoic acid-related orphans","Acetylcholine receptors (muscarinic)","CYP1 family",Lipoxygenases,"1.14.11.- Histone demethy
lases","CYP3 family","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System","Vesicle-mediated transport","Immune System","DNA Repair","Cell Cycle",Disease,Metabolism,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kin
ases","Transmission across Chemical Synapses","Membrane Trafficking","Innate Immune System","DNA Double-Strand Break Repair",Mitotic,"Diseases of metabolism","Metabolism of lipids","Infectious disease
","Biological oxidations","RNA Polymerase II Transcription","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Toll-like Rece
ptor Cascades","Homology Directed Repair","Mitotic G1 phase and G1/S transition","Diseases of carbohydrate metabolism","M Phase","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania
 infection","Phase I - Functionalization of compounds","Generic Transcription Pathway","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biog
enesis","Toll Like Receptor 5 (TLR5) Cascade","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","G1/S Transition","Glycogen storage diseases","Mitotic Metaphase and Anaphas
e","Biosynthesis of DHA-derived SPMs","Leishmania parasite growth and survival","Ethanol oxidation","Transcriptional Regulation by TP53","Signalling to ERKs","Post NMDA receptor activation events","My
D88 cascade initiated on plasma membrane","HDR through Homologous Recombination (HRR)","Activation of the pre-replicative complex","Glycogen storage disease type II (GAA)","Mitotic Anaphase","Biosynth
esis of D-series resolvins","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of TP53 Activity","Prolonged ERK activation events","Activation of AMPK downstream of NMDAR
s","MAP kinase activation","Homologous DNA Pairing and Strand Exchange","Nuclear Envelope (NE) Reassembly","ADORA2B mediated anti-inflammatory cytokines production","Regulation of TP53 Expression and 
Degradation","Regulation of TP53 Activity through Phosphorylation","Frs2-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","Presynaptic phase of homologous DNA pairing and st
rand exchange","Initiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","ARMS-mediated activation","ERK/MAPK targets","Activation of the AP-1 family of transcription factors"
,"ERKs are inactivated","Cellular responses to external stimuli",Hemostasis,"Signaling by GPCR","Metabolism of amino acids and derivatives","Cellular responses to stress","Platelet activation","signal
ing and aggregation","Uptake and actions of bacterial toxins","GPCR ligand binding","Branched-chain amino acid catabolism","GPCR downstream signalling","Cellular response to hypoxia","Platelet Aggrega
tion (Plug Formation)","Cytochrome P450 - arranged by substrate type","Transcriptional regulation by RUNX3","Uptake and function of anthrax toxins","Class A/1 (Rhodopsin-like receptors)","G alpha (q) 
signalling events","Biosynthesis of DPA-derived SPMs","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha",Xenobiotics,"RUNX3 Regulates Immune Response and Cell Migration","Amine
 ligand-binding receptors","Gastrin-CREB signalling pathway via PKC and MAPK","Biosynthesis of DPAn-3 SPMs","Biosynthesis of maresins","CYP2E1 reactions","Muscarinic acetylcholine receptors","EGFR Tra
nsactivation by Gastrin","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of DPAn-3-derived protectins and resolvins","Biosynthesis of DPAn-3-derived maresins","Biosynt
hesis of maresin-like SPMs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{U0126,109511-58-2,109511582,"109511 58 2",U-0126,"U 0126","1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene","1,4Diamino2,3dicyano1,4bis(oaminophenylmercapto)butadiene","1,4 Diamino 2,
3 dicyano 1,4 bis(o aminophenylmercapto)butadiene",EI-282,1144}

> <pdid>
PD014850

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{3006531}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 C   0  0
    2.5973   -1.5031    0.0000 S   0  0
    2.5951   -3.0031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 N   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.8193    4.6606    0.0000 C   0  0
   -4.0353    5.9336    0.0000 C   0  0
   -4.7489    7.2530    0.0000 C   0  0
   -6.2483    7.2947    0.0000 C   0  0
   -6.9619    8.6141    0.0000 F   0  0
   -7.0341    6.0170    0.0000 C   0  0
   -6.3205    4.6976    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -6.4469    1.8311    0.0000 C   0  0
   -7.4153    2.9701    0.0000 C   0  0
   -8.8906    2.6991    0.0000 C   0  0
   -9.3937    1.2860    0.0000 N   0  0
   -8.4213    0.1438    0.0000 C   0  0
   -6.9460    0.4147    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 13  1  0
 12 20  2  0
 20 21  1  0
 21 10  2  0
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28098

> <plate>
Kinase v5-1

> <well>
C05

> <supplier_cmpd_name>
SB-203580

> <ctcr_id>
4877

> <supplier_cmpd_id>
EI-286

> <smiles>
C[S](=O)c1ccc(cc1)c2[nH]c(c3ccc(F)cc3)c(n2)c4ccncc4

> <pd_targets>
{TNNI3K,GSK3B,RPS6KA6,MAPK14,MAPK11,MAPK12,MAPK13,TGFBR1,ACVR1B,LCK,TYK2,NLK,KMT2A,MEN1,HSD17B10,CSNK1A1,RAF1,MAPK9,EGFR,CYP2D6,TTK,RIPK2,GAK,CSNK1D,BRAF,MAP2K1,MAP2K2,CYP1A2,CYP3A4,HTR4,FRK,MAPK10,ST
K36,PTK6,SLK,TNIK,CDC42BPG,CDPK1,TXK,CDC42BPB,MAPK-1,RPS6KA1,EPHA6,SRC,MAPK1,STK32B,LEF,ERBB4,ALDH1A1,EPHB2,CSNK1E,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,CYP2C9,CYP2C19,MAPK
8,MAP4K4,MET,CIT,COQ8B,TGFBR2,PTGS1,ABL1,SIK2,KDM4E,SIK3,STK32A,ALOX5,TEK,DDR2,P2RX7,DDR1,ALOX15,HPGD,MAP2K5,FLT4,MAP3K20,CSNK1A1L,CDC42BPA,GCGR,PRKACA,PRKACB,PRKACG,TSHR,MINK1,BMPR1B,PIP5K1C,PRKD2,EP
HB6,TBXAS1,PDE5A,ADORA1,ADORA2A,CHRM1,ERBB2,TYR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Membrane receptor","Ion channel","Unclassified protein",Kinase,Reader,Oxidoreductase,"Cytochrome P450","Family A G protein-coupled receptor",Protease,Eraser,"Ligand-gat
ed ion channel","Family B G protein-coupled receptor",Transferase,Phosphodiesterase,"Protein Kinase",Bromodomain,"Cytochrome P450 family 2","Cytochrome P450 family 1","Cytochrome P450 family 3","Small
 molecule receptor (family A GPCR)","Metallo protease","Lysine demethylase","P2X receptor","Peptide receptor (family B GPCR)","Peptide receptor (family A GPCR)","Cytochrome P450 family 5","Phosphodies
terase 5","TKL protein kinase group","CMGC protein kinase group","AGC protein kinase group","TK protein kinase group","CK1 protein kinase group","Cytochrome P450 family 2D","Other protein kinase group
","STE protein kinase group","Cytochrome P450 family 1A","Cytochrome P450 family 3A","Monoamine receptor","Metallo protease MAE clan","Cytochrome P450 family 2C","Atypical protein kinase group","CAMK 
protein kinase group","Jumonji domain-containing","Glucagon-like receptor","Glycohormone receptor","Cytochrome P450 family 5A","Phosphodiesterase 5A","Nucleotide-like receptor (family A GPCR)","TKL pr
otein kinase MLK family","CMGC protein kinase GSK family","AGC protein kinase RSK family","CMGC protein kinase MAPK family","TKL protein kinase STKR family","Tyrosine protein kinase Src family","Tyros
ine protein kinase JakA family","CK1 protein kinase CK1 family","TKL protein kinase RAF family","Tyrosine protein kinase EGFR family","Cytochrome P450 2D6","Other protein kinase TTK family","TKL prote
in kinase RIPK family","Other protein kinase NAK family","STE protein kinase STE7 family","Cytochrome P450 1A1","Cytochrome P450 3A4","Serotonin receptor","Other protein kinase ULK family","STE protei
n kinase STE20 family","AGC protein kinase DMPK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Eph family","AGC protein kinase YANK family","Metallo protease M34 family","AGC pr
otein kinase PKC family","Cytochrome P450 2C9","Cytochrome P450 2C19","Tyrosine protein kinase Met family","Atypical protein kinase ABC1 family","Tyrosine protein kinase Abl family","CAMK protein kina
se CAMK1 family","Tyrosine protein kinase Tie family","Tyrosine protein kinase DDR family","Tyrosine protein kinase VEGFR family","Glucagon receptor","AGC protein kinase PKA family","CAMK protein kina
se PKD family","Cytochrome P450 5A1","Adenosine receptor","Acetylcholine receptor","TKL protein kinase HH498 subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase p38 subfamily","TKL prot
ein kinase STKR Type 1 subfamily","CMGC protein kinase nmo subfamily","CMGC protein kinase JNK subfamily","STE protein kinase SLK subfamily","STE protein kinase MSN subfamily","AGC protein kinase GEK 
subfamily","CMGC protein kinase ERK1","AGC protein kinase PKC alpha subfamily","AGC protein kinase CRIK subfamily","Atypical protein kinase ABC1-A subfamily","TKL protein kinase STKR Type 2 subfamily"
,"CAMK protein kinase QIK subfamily","TKL protein kinase MLK subfamily","CK1 protein kinase CK1-a"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","Chromatin modifying enzymes","Ligand-gated ion cha
nnels","Cyclic nucleotide turnover/signalling","1.-.-.- Oxidoreductases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase
 1","CYP2 family: drug metabolising subset","CYP1 family","CYP3 family","5-Hydroxytryptamine receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Atypical,Cyclooxygenase,"CA
MK: Calcium/calmodulin-dependent protein kinases","1.14.11.- Histone demethylases",Lipoxygenases,"P2X receptors","Prostaglandin synthases","Glucagon receptor family","Glycoprotein hormone receptors","
Lipid modifying kinases",CYP5,"CYP7 and CYP8 families",Phosphodiesterases,3',"5'-cyclic nucleotide (PDEs)","Adenosine receptors","Acetylcholine receptors (muscarinic)","TKL: Tyrosine kinase-like","Gly
cogen synthase kinase (GSK) family","RSK family","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","Other protein kinases","STE20 family","DMPK fam
ily","YANK family","STE7 family","ABC1 family","CAMK-like (CAMKL) family","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","Protein kinase D (PKD) family","Mixed Lineage Kinas
e (MLK) family","GSK subfamily","RSK subfamily","p38 subfamily","Receptor serine/threonine kinase (RSTK) family","Non-receptor tyrosine kinases (nRTKs)","nmo subfamily","RAF family","JNK subfamily","R
eceptor tyrosine kinases (RTKs)","TTK family","Receptor interacting protein kinase (RIPK) family","Numb-associated kinase (NAK) family","Unc-51-like kinase (ULK) family","SLK subfamily","MSN subfamily
","GEK subfamily","ERK subfamily","Other DMPK family kinases","ABC1-B subfamily","QIK subfamily","HH498 subfamily","Type I receptor serine/threonine kinases","Src family","Janus kinase (JakA) family",
"Type I RTKs: ErbB (epidermal growth factor) receptor family","Tec family","Type XIII RTKs: Ephrin receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type II receptor seri
ne/threonine kinases","Abl family","Type XII RTKs: TIE family of angiopoietin receptors","Type XVI RTKs: DDR (collagen receptor) family","Type IV RTKs: VEGF (vascular endothelial growth factor) recept
or family","MLK subfamily"}

> <pathway_reactome>
{Disease,"Neuronal System","Immune System","Developmental Biology","Signal Transduction",Metabolism,"Vesicle-mediated transport","Cell Cycle","Cellular responses to external stimuli","Extracellular ma
trix organization",Hemostasis,"Infectious disease","Transmission across Chemical Synapses","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Si
gnaling by NODAL","Cytokine Signaling in Immune system","Signaling by WNT","Metabolism of amino acids and derivatives","MAPK family signaling cascades","Signaling by GPCR","Biological oxidations","Sig
naling by Receptor Tyrosine Kinases","Membrane Trafficking",Mitotic,"Metabolism of lipids","Intracellular signaling by second messengers","Cellular responses to stress","Nervous system development","S
ignaling by Rho GTPases","Non-integrin membrane-ECM interactions","Signaling by TGFB family members","Platelet homeostasis","SARS-CoV Infections","Neurotransmitter receptors and postsynaptic signal tr
ansmission","Toll-like Receptor Cascades","Signaling by TGF-beta Receptor Complex in Cancer","Regulation of signaling by NODAL","HIV Infection","Interferon Signaling","Beta-catenin independent WNT sig
naling","Branched-chain amino acid catabolism","Signaling by WNT in cancer","MAPK1/MAPK3 signaling","GPCR downstream signalling","Phase I - Functionalization of compounds","Signaling by NTRKs","trans-
Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","PIP3 activates AKT signaling","Mitotic G1 phase and G1/S tra
nsition","Cellular Senescence","Fc epsilon receptor (FCERI) signaling","Axon guidance","Uptake and actions of bacterial toxins","RHO GTPase Effectors","Fatty acid metabolism","Signaling by VEGF","Sign
aling by BMP","Sphingolipid metabolism","Nitric oxide stimulates guanylate cyclase","GPCR ligand binding","Melanin biosynthesis","SARS-CoV-1 Infection","Activation of NMDA receptors and postsynaptic e
vents","Toll Like Receptor 5 (TLR5) Cascade","Loss of Function of SMAD2/3 in Cancer","Host Interactions of HIV factors","Interferon alpha/beta signaling","Ca2+ pathway","Signaling by AMER1 mutants","R
AF/MAP kinase cascade","G alpha (q) signalling events","Cytochrome P450 - arranged by substrate type","Signaling by NTRK1 (TRKA)","Golgi Associated Vesicle Biogenesis","G2/M Transition","Biosynthesis 
of DHA-derived SPMs","Leishmania parasite growth and survival","PTEN Regulation","G1 Phase","Oxidative Stress Induced Senescence","FCERI mediated Ca+2 mobilization","EPH-Ephrin signaling","Uptake and 
function of anthrax toxins","Ethanol oxidation","Semaphorin interactions","RHO GTPases activate CIT","Arachidonic acid metabolism","Parasite infection","Biosynthesis of DPA-derived SPMs","Cell recruit
ment (pro-inflammatory response)","VEGF ligand-receptor interactions","Sphingolipid de novo biosynthesis","cGMP effects","Class A/1 (Rhodopsin-like receptors)","SARS-CoV-1 Genome Replication and Trans
cription","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","SMAD2/3 Phosphorylation Motif Mutants in Cancer","The role of Nef in HIV-1 replication and disease pathog
enesis","Regulation of IFNA signaling","Truncations of AMER1 destabilize the destruction complex","Negative regulation of MAPK pathway","Gastrin-CREB signalling pathway via PKC and MAPK",Xenobiotics,"
Signalling to ERKs","Centrosome maturation","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of PTEN stability and activity","Cyclin D associ
ated events in G1","EPHA-mediated growth cone collapse","EPHB-mediated forward signaling","Sema4D in semaphorin signaling","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)","Leishmania phagocyt
osis","Biosynthesis of DPAn-3 SPMs","Purinergic signaling in leishmaniasis infection","Biosynthesis of D-series resolvins","Signalling to ERK5","VEGF binds to VEGFR leading to receptor dimerization","
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion",Eicosanoids,"Nucleotide-like (purinergic) receptors","Amine ligand-binding receptors","Replication of the SARS-CoV-1 genome","CREB1 p
hosphorylation through NMDA receptor-mediated activation of RAS signaling","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Neg
ative feedback regulation of MAPK pathway","EGFR Transactivation by Gastrin","CYP2E1 reactions","Signalling to RAS","Loss of proteins required for interphase microtubule organization from the centroso
me","Prolonged ERK activation events","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammatory cytokines production","
Long-term potentiation","Sema4D mediated inhibition of cell attachment and migration","FCGR3A-mediated phagocytosis","Biosynthesis of DPAn-3-derived 13-series resolvins","Biosynthesis of DPAn-3-derive
d protectins and resolvins","Adenosine P1 receptors","Muscarinic acetylcholine receptors","Sema4D induced cell migration and growth-cone collapse","RSK activation","MAPK targets/ Nuclear events mediat
ed by MAP kinases","Nef Mediated CD4 Down-regulation","p38MAPK events","activated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","ARMS-mediated activation","Frs2-mediated ac
tivation","Activation of the AP-1 family of transcription factors","CREB phosphorylation","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,ALOX5,CHEK1,CYP2D6,CYP3A4,GAK,GSK3B,LCK,MAPK1,MAPK10,MAPK11,MAPK12,MAPK14,MAPK8,MAPK9,PRKCA,RAF1,RIPK2,ROCK1,RPS6KB1,SGK1,SRC,TNF}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{B20358,152121-47-6,152121476,"SB 203580",SB-203580,SB203580,4-(4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl)pyridine,4(4(4fluorophenyl)2(4methylsulfinylphenyl)1Himidazol5yl)pyridine
,4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole,4(4Fluorophenyl)2(4methylsulfinylphenyl)5(4pyridyl)1Himidazole,"RWJ 64809",4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)ph,4(4Fluor
ophenyl)2(4(methylsulfinyl)ph,"EMD 559389",S1076,EI-286,559389}

> <pdid>
PD004782

> <targets>
{"p38 MAPK","P38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{176155}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 42  0  0  1  0            999 V2000
   -1.7668    6.0997    0.0000 C   0  0
   -2.5381    4.8132    0.0000 N   0  0
   -1.8100    3.5000    0.0000 C   0  0  2  0  0  0
   -0.2400    3.5200    0.0000 C   0  0
    0.5000    2.1800    0.0000 C   0  0  1  0  0  0
   -1.0600    2.1800    0.0000 O   0  0
   -1.8300    0.9300    0.0000 C   0  0  1  0  0  0
   -3.1401    0.1996    0.0000 C   0  0
   -2.6500    2.2500    0.0000 C   0  0  2  0  0  0
   -4.1488    2.2849    0.0000 O   0  0
   -4.9300    1.0044    0.0000 C   0  0
   -0.9800   -0.7800    0.0000 N   0  0
   -2.1300   -1.4600    0.0000 C   0  0
   -3.3200   -0.7600    0.0000 C   0  0
   -4.5500   -1.4800    0.0000 C   0  0
   -4.5800   -2.7700    0.0000 C   0  0
   -3.3400   -3.4700    0.0000 C   0  0
   -2.1300   -2.7900    0.0000 C   0  0
    0.2400   -2.7700    0.0000 C   0  0
    1.4300   -3.4700    0.0000 C   0  0
    1.7600   -4.9700    0.0000 C   0  0
    3.2600   -5.0800    0.0000 N   0  0
    3.8500   -3.6300    0.0000 C   0  0
    5.2941   -3.2244    0.0000 O   0  0
    2.6600   -2.7500    0.0000 C   0  0
    2.6800   -1.4600    0.0000 C   0  0
    3.7900    0.5600    0.0000 C   0  0
    4.9600    1.2800    0.0000 C   0  0
    4.9600    2.6300    0.0000 C   0  0
    3.8100    3.2900    0.0000 C   0  0
    2.6400    2.5900    0.0000 C   0  0
    2.6400    1.2400    0.0000 C   0  0
    1.4900    0.5400    0.0000 N   0  0
    1.4500   -0.7600    0.0000 C   0  0
    0.2400   -1.4400    0.0000 C   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  5  4  1  6
  5  6  1  0
  6  7  1  0
  7  8  1  1
  7  9  1  0
  9  3  1  0
  9 10  1  6
 10 11  1  0
  7 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 20  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 32 33  1  0
 33  5  1  0
 33 34  1  0
 34 26  1  0
 34 35  2  0
 35 12  1  0
 35 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28101

> <plate>
Kinase v5-1

> <well>
C11

> <supplier_cmpd_name>
Staurosporine

> <ctcr_id>
3125

> <supplier_cmpd_id>
EI-156

> <smiles>
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

> <pd_targets>
{HUNK,MAP2K1,RAF1,TNIK,GSK3B,EGFR,MAPK1,MYLK,LCK,CCND1,CDK4,KDR,CDK2,RPS6KA2,MARK2,RPS6KA5,CAMK1D,CDK6,PIM2,NEK2,MAP3K5,PTK2,PIM1,STK3,PIP5K1A,RPS6KA6,MAP3K13,STK25,PRKACB,PRKX,CSNK1A1L,CSNK1D,TLK1,TL
K2,RIPK4,MAP3K19,DYRK1A,NEK11,SBK3,CDPK1,CCNE1,CDK3,CCNA2,CSNK1A1,CSNK1E,CSNK1G1,CSNK1G2,IGF1R,PRKACA,PRKCG,ABL1,MYO3B,FRK,AURKC,MAPK10,STK36,YES1,PLK4,FLT3,KIT,FLT4,PDGFRB,FGFR3,AURKA,MET,JAK3,TYRO3,
PDGFRA,CCNB1,CDK1,CCNT1,CDK9,CHUK,ZAP70,CHEK2,DAPK1,FLT1,NUAK1,PIM3,MAP4K3,AURKB,BLK,MAP4K4,MAP3K10,MAP3K11,MUSK,DCLK1,DCLK3,MYO3A,ULK3,STK32A,ERN1,MST1R,NEK4,RPS6KB1,ULK1,DYRK2,CDK13,ROCK2,MAP3K1,STK
38,CILK1,CCNO,DYRK3,KSR2,PRKCA,PRKCB,PRKCD,PRKCE,PRKCH,PRKCQ,PRKCZ,SRC,FGR,MAPK9,LYN,BTK,EPHA3,CDK7,SLK,RIPK2,EPHA4,EPHA5,PRKAA1,PHKG2,FYN,FGFR2,PAK5,CAMK2B,PAK3,CAMK2G,CAMKK1,AKT1,AKT3,TGFBR1,CHEK1,M
APKAPK2,MAPK3,LIMK2,MARK3,MAP2K2,STK26,INSRR,ITK,JAK1,RIOK3,SRPK1,ACVR1B,SRPK2,TNK1,ALK,DDR2,DMPK,LATS1,EPHA1,PKN1,PKN2,PLK1,MAPK7,MAPK15,PRKD2,HIPK4,PRKG2,PTK6,PDK1,PRKACG,CCNE2,MAP2K4,MAP2K6,IKBKB,G
RK4,HCK,STK17A,MAP3K4,CLK1,CLK4,MAPK8,CAMKK2,CAMK1G,TEC,NIM1K,CDK5,CDK5R1,ERBB4,HIPK1,AXL,BRAF,MARK1,MARK4,MERTK,CDK8,MAP3K9,CDC42BPA,STK24,CIT,MAP2K5,MAPT,GRK1,HIPK3,MAP3K12,SRPK3,GRK6,SGK1,MAPKAPK3,
PRKCI,MAPK12,STK4,DAPK2,STK16,DAPK3,CLK2,NTRK1,NEK9,CLK3,DSTYK,LIMK1,MYLK2,TNK2,PAK2,PLK2,RET,CCNH,CHRM1,ROCK1,RPS6KA1,TAB1,ROS1,CDK18,CDK14,STK32C,NTRK2,NTRK3,GSK3A,CDK15,STK38L,CDK16,FER,MAP3K7,CDK1
7,PTK2B,TIE1,TYK2,TAOK3,TAOK1,HIPK2,LRRK2,CCNK,CCNA1,EPHA7,EPHB1,DDR1,MKNK2,STK10,EPHA6,FGFR1,TEK,EPHA2,JAK2,PAK4,SYK,PAK1,CAMK2D,PAK6,IKBKE,NEK7,EIF2AK4,STK32B,PFMRK,LATS2,CDC42BPG,NEK1,SIK1,TESK1,PL
K3,EPHB2,ERBB2,PRKD1,PRKG1,MAK,FGFR4,RPS6KA4,PKN3,TSSK6,CAMK2A,PRKD3,AKT2,TBK1,STK11,MAP2K3,MAPK14,SIK2,STK33,TNNI3K,LTK,ANKK1,OSR1,CSNK2A1,CSNK2A2,CSNK2B,CCNB2,CCNB3,INSR,STK17B,CAMK1,IRAK4,BMPR1A,BR
SK1,CAMK4,CDK19,CSF1R,DCLK2,SIK3,CCNC,CCND3,CCNT2,GRK5,CSK,AAK1,BMPR2,CDC42BPB,RECQL,KMT2A,MEN1,MAP3K15,SBK1,BMPR1B,PI4KB,MAPK13,CDKL5,PRPF4B,CDKL1,MAP3K2,SGK3,BCR,CDC7,DBF4,CCNY,HASPIN,KSR1,TTK,RPS6K
A3,MINK1,MYLK4,PIP4K2B,DYRK1B,MAP2K7,MYLK3,PDPK1,STK35,BMP2K,MAP4K5,ABL2,EPHA8,MELK,MKNK1,IRAK3,ACVR1,ACVR2A,NEK5,BRSK2,NUAK2,FES,RPS6KB2,WNK2,MAPKAPK5,MAP3K3,PIK3CG,MAP3K6,STK39,TAOK2,ABCB11,MNAT1,NL
K,ACVR2B,TSSK1B,PRKAA2,ACVRL1,SRMS,TUBA1A,MAPK6,EIF2AK2,SGK2,TSSK2,WNK1,CHRM2,KARS1,CSNK1G3,TXK,SNRK,GRK7,EPHB4,MAP4K1,IRAK1,EPHB6,PIP5K1C,ULK2,MAST1,ERBB3,PNCK,BMX,GAK,PHKG1,EPHB3,NEK8,PBK,PEAK1,CHRM
4,RIOK2,PKNB,CRK2,PHKA1,PHKA2,PHKB,ALDH1A1,MATK,CASK,CDKL2,PIK3C2G,ERN2,GRK2,GRK3,MAP3K21,WEE1,RIOK1,PASK,TSSK3,PIK3CA,CDKL3,NEK3,MAP4K2,OXSR1,GCK,CYP11B2,TERT,MAP3K14,CDK12,RB1,ABCC4}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Membrane receptor","Unclassified protein","Epigenetic regulator",Transporter,"Structural protein",Kinase,Transferase,"Family A G protein-coupled receptor",Reader,"Pr
imary active transporter",Oxidoreductase,"Cytochrome P450","Protein Kinase","Small molecule receptor (family A GPCR)",Bromodomain,"ATP-binding cassette","Cytochrome P450 family 11","CAMK protein kinas
e group","STE protein kinase group","CMGC protein kinase group","TK protein kinase group","AGC protein kinase group","Other protein kinase group","TKL protein kinase group","CK1 protein kinase group",
"Atypical protein kinase group","Monoamine receptor","ABCB subfamily","Cytochrome P450 family 11B","ABCC subfamily","STE protein kinase STE7 family","STE protein kinase STE20 family","CMGC protein kin
ase GSK family","Tyrosine protein kinase EGFR family","CMGC protein kinase MAPK family","CAMK protein kinase MLCK family","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","C
MGC protein kinase CDK family","AGC protein kinase RSK family","CAMK protein kinase CAMK1 family","CAMK protein kinase PIM family","Other protein kinase NEK family","STE protein kinase STE11 family","
Tyrosine protein kinase Fak family","TKL protein kinase MLK family","AGC protein kinase PKA family","CK1 protein kinase CK1 family","Other protein kinase TLK family","TKL protein kinase RIPK family","
CMGC protein kinase DYRK family","Other protein kinase NKF1 family","Tyrosine protein kinase InsR family","AGC protein kinase PKC family","Tyrosine protein kinase Abl family","Other protein kinase AUR
 family","Other protein kinase ULK family","Other protein kinase PLK family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase Met family","Tyrosine
 protein kinase JakA family","Tyrosine protein kinase Axl family","Other protein kinase IKK family","Tyrosine protein kinase Syk family","CAMK protein kinase RAD53 family","CAMK protein kinase DAPK fa
mily","Tyrosine protein kinase Musk family","CAMK protein kinase DCAMK1 family","AGC protein kinase YANK family","AGC protein kinase DMPK family","AGC protein kinase NDR family","CMGC protein kinase R
CK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Eph family","CAMK protein kinase PHk family","CAMK protein kinase CAMK2 family","Other protein kinase CAMKK family","AGC protei
n kinase AKT family","TKL protein kinase STKR family","CAMK protein kinase MAPKAPK family","TKL protein kinase RAF family","TKL protein kinase LISK family","Atypical protein kinase RIO family","CMGC p
rotein kinase SRPK family","Tyrosine protein kinase Ack family","Tyrosine protein kinase DDR family","AGC protein kinase PKN family","CAMK protein kinase PKD family","AGC protein kinase PKG family","A
typical protein kinase PDHK subfamily","AGC protein kinase GRK family","CMGC protein kinase CLK family","AGC protein kinase SGK family","Other protein kinase NAK family","Tyrosine protein kinase Trk f
amily","Tyrosine protein kinase Ret family","Acetylcholine receptor","Tyrosine protein kinase Sev family","Tyrosine protein kinase Fer family","Tyrosine protein kinase Tie family","TKL protein kinase 
LRRK family","Other protein kinase PEK family","CAMK protein kinase TSSK family","CAMK protein kinase unique family","Tyrosine protein kinase Alk family","Other protein kinase CK2 family","TKL protein
 kinase IRAK family","Tyrosine protein kinase Csk family","CMGC protein kinase CDKL family","Atypical protein kinase BCR family","Other protein kinase CDC7 family","Other protein kinase Haspin family"
,"Other protein kinase TTK family","AGC protein kinase PDK1 subfamily","Other protein kinase NKF4 family","Other protein kinase Wnk family","AGC protein kinase MAST family","Other protein kinase TOPK 
family","Other protein kinase WEE family","Cytochrome P450 11B2","STE protein kinase unique family","STE protein kinase MSN subfamily","CMGC protein kinase ERK1","CMGC protein kinase CDC2 subfamily","
AGC protein kinase RSK subfamily","CAMK protein kinase MARK subfamily","AGC protein kinase MSK subfamily","STE protein kinase MST subfamily","TKL protein kinase LZK subfamily","STE protein kinase YSK 
subfamily","CK1 protein kinase CK1-a","CMGC protein kinase Dyrk1 subfamily","Other protein kinase Nek11","AGC protein kinase PKC alpha subfamily","STE protein kinase NinaC subfamily","CMGC protein kin
ase JNK subfamily","CMGC protein kinase CDK9 subfamily","CAMK protein kinase NuaK subfamily","STE protein kinase KHS subfamily","TKL protein kinase MLK subfamily","AGC protein kinase p70 subfamily","C
MGC protein kinase Dyrk2 subfamily","AGC protein kinase ROCK subfamily","CMGC protein kinase MAK","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase SLK 
subfamily","CAMK protein kinase AMPK subfamily","Tyrosine protein kinase SrcA","STE protein kinase PAKB subfamily","STE protein kinase PAKA subfamily","Other protein kinase Meta subfamily","TKL protei
n kinase STKR Type 1 subfamily","CAMK protein kinase CHK1 subfamily","CAMK protein kinase MAPKAPK subfamily","TKL protein kinase LIMK subfamily","Atypical protein kinase RIO3 subfamily","AGC protein k
inase GEK subfamily","CMGC protein kinase ERK5","CMGC protein kinase HIPK subfamily","AGC protein kinase GRK subfamily","CAMK protein kinase NIM1 subfamily","CMGC protein kinase CDK8 subfamily","AGC p
rotein kinase CRIK subfamily","AGC protein kinase PKC iota subfamily","CMGC protein kinase p38 subfamily","Other protein kinase PLK2","CMGC protein kinase PCTAIRE","CMGC protein kinase PFTAIRE","CMGC 
protein kinase TAIRE subfamily","CMGC protein kinase CDK5 subfamily","TKL protein kinase TAK1 subfamily","STE protein kinase TAO subfamily","AGC protein kinase PKC eta subfamily","CAMK protein kinase 
MNK subfamily","Other protein kinase GCN2 subfamily","CAMK protein kinase QIK subfamily","TKL protein kinase TESK subfamily","CAMK protein kinase LKB subfamily","TKL protein kinase HH498 subfamily","C
AMK protein kinase BRSK subfamily","TKL protein kinase STKR Type 2 subfamily","STE protein kinase ASK","STE protein kinase MEKK2","CAMK protein kinase MELK subfamily","TKL protein kinase STKR1","STE p
rotein kinase FRAY subfamily","CMGC protein kinase nmo subfamily","Tyrosine protein kinase Srm","CMGC protein kinase ERK3","Other protein kinase PKR","CK1 protein kinase CK1-g","Atypical protein kinas
e RIO2 subfamily","AGC protein kinase BARK subfamily","Atypical protein kinase RIO1 subfamily","CAMK protein kinase PASK subfamily","Other protein kinase Nek1"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Other protein targets","Kinases (EC 2.7.x.x)","Catalytic receptors","G protein-coupled receptors","ATP-binding cassette transporter family",Tubulins,"Cytochrome P450",
"CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","AGC: Conta
ining PKA",PKG,"PKC families","Lipid modifying kinases","CK1: Casein kinase 1",Atypical,"Acetylcholine receptors (muscarinic)","ABCB subfamily","Miscellaneous protein kinases",CYP11,CYP17,CYP19,"CYP20
 and CYP21 families","ABCC subfamily","CAMK-like (CAMKL) family","STE20 family","Glycogen synthase kinase (GSK) family","TK: Tyrosine kinase","STE7 family","Mitogen-activated protein kinases (MAP kina
ses)","Myosin Light Chain Kinase (MLCK) family","Cyclin-dependent kinase (CDK) family","RSK family","CAMK1 family","PIM family","Other protein kinases","STE11 family","Type I PIP kinases (1-phosphatid
ylinositol-4-phosphate 5-kinase family)","TKL: Tyrosine kinase-like","Protein kinase A (PKA) family","Casein kinase 1 (CK1) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYR
K) family","Protein kinase C (PKC) family","Death-associated kinase (DAPK) family","DCAMKL family","YANK family","DMPK family","NDR family","RCK family","Phosphorylase kinase (PHK) family","CAMK2 fami
ly","Akt (Protein kinase B","PKB) family","MAPK-Activated Protein Kinase (MAPKAPK) family","RIO family","SRPK family","Protein kinase N (PKN) family","Protein kinase D (PKD) family","Protein kinase G 
(PKG) family","PDHK family","G protein-coupled receptor kinases (GRKs)","CLK family","SGK family","Testis specific kinase (TSSK) family","CAMK-unique family","1-phosphatidylinositol 4-kinase family","
Cyclin-dependent kinase-like (CDKL) family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","PDK1 family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","MAST famil
y","CASK family","Phosphatidylinositol-4-phosphate 3-kinase family",Hexokinases,"STE-unique family","HUNK subfamily","MSN subfamily","GSK subfamily","Receptor tyrosine kinases (RTKs)","ERK subfamily",
"Non-receptor tyrosine kinases (nRTKs)","CDK1 subfamily","RSK subfamily","MARK subfamily","MSK subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","MST subfamily","Mixed Lineage K
inase (MLK) family","YSK subfamily","Tousled-like kinase (TLK) family","Receptor interacting protein kinase (RIPK) family","STE20 subfamily","Dyrk1 subfamily","NKF1 family","Alpha subfamily","NinaC su
bfamily","Aurora kinase (Aur) family","JNK subfamily","Unc-51-like kinase (ULK) family","Polo-like kinase (PLK) family","IKK family","CHK1 subfamily","NuaK subfamily","KHS subfamily","IRE family","p70
 subfamily","Dyrk2 subfamily","CRK7 subfamily","Rho kinase","RAF family","Delta subfamily","CDK7 subfamily","SLK subfamily","AMPK subfamily","PAKB subfamily","PAKA subfamily","CAMKK family","Receptor 
serine/threonine kinase (RSTK) family","MAPKAPK subfamily","LIM domain kinase (LISK) family","RIO3 subfamily","GEK subfamily","Erk7 subfamily","HIPK subfamily","GRK4 subfamily","NIM1 subfamily","CDK8 
subfamily","Other DMPK family kinases","Opsin/rhodopsin kinases","Iota subfamily","p38 subfamily","NAK family","Other-unique family","TAIRE subfamily","CDK5 subfamily","TAO subfamily","Leucine-rich re
peat kinase (LRRK) family","Eta subfamily","MKN subfamily","PEK family","QIK subfamily","LKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","BRSK subfamily","CDK4 subfamily","PRP4
 subfamily","Haspin family","TTK family","Casein kinase 2 (CK2) family","NKF4 family","Numb-associated kinase (NAK) family","MELK subfamily","Wnk family","FRAY subfamily","nmo subfamily","CDK9 subfami
ly","SNRK subfamily","TOPK family","RIO2 subfamily","Beta-adrenergic receptor kinases (&beta;ARKs)","WEE family","RIO1 subfamily","PASK subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor
 family","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Fak family","LZK subfamily","Type II RTKs: Insulin receptor family","Abl family","Type III RTKs: PDGFR"
,CSFR,Kit,"FLT3 receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Janus kinase (JakA) family","Type XI RTKs:
 TAM (TYRO3-","AXL- and MER-TK) receptor family","Syk family","MLK subfamily","Type IX RTKs: MuSK","Tec family","Type XIII RTKs: Ephrin receptor family","Meta subfamily","Type I receptor serine/threon
ine kinases","LIMK subfamily","Ack family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Type VII RTKs: Neurotrophin receptor/Trk fa
mily","Type XIV RTKs: RET","Type XVII RTKs: ROS receptors","Fer family","TAK1 subfamily","Type XII RTKs: TIE family of angiopoietin receptors","GCN2 subfamily","TESK subfamily","HH498 subfamily","Csk 
family","Type II receptor serine/threonine kinases","Other PEK family kinases"}

> <pathway_reactome>
{"Cellular responses to external stimuli",Disease,"Signal Transduction","Immune System","Gene expression (Transcription)","Cell Cycle",Metabolism,"Neuronal System","Developmental Biology","Programmed 
Cell Death","Extracellular matrix organization","Metabolism of proteins",Autophagy,"DNA Repair","Metabolism of RNA","Muscle contraction","Organelle biogenesis and maintenance",Hemostasis,"Circadian Cl
ock","Cell-Cell communication","Vesicle-mediated transport","Transport of small molecules","Cellular responses to stress","Infectious disease","Signaling by GPCR","Signaling by Receptor Tyrosine Kinas
es","Innate Immune System","Signaling by Rho GTPases","RNA Polymerase II Transcription",Mitotic,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Hippo",
"Metabolism of lipids","Transmission across Chemical Synapses","Intracellular signaling by second messengers","Nervous system development","Cytokine Signaling in Immune system","Adaptive Immune System
",Apoptosis,"ECM proteoglycans","Signaling by Hedgehog","Unfolded Protein Response (UPR)","MTOR signalling",Macroautophagy,"Metabolism of carbohydrates","DNA Double-Strand Break Repair","MAPK family s
ignaling cascades","rRNA processing","Signaling by NODAL","Non-integrin membrane-ECM interactions","Cardiac conduction","The citric acid (TCA) cycle and respiratory electron transport","Cilium Assembl
y","Cell surface interactions at the vascular wall","Death Receptor Signalling","Signaling by Non-Receptor Tyrosine Kinases","Cell junction organization","Platelet homeostasis","Signaling by TGFB fami
ly members","Disorders of Developmental Biology","Membrane Trafficking","Ion channel transport","Signaling by WNT",Translation,"Biological oxidations","Cell Cycle Checkpoints","Signaling by Nuclear Re
ceptors","Chromosome Maintenance","Platelet activation","signaling and aggregation","Cellular Senescence","SARS-CoV Infections","GPCR downstream signalling","Signaling by NTRKs","Toll-like Receptor Ca
scades","RHO GTPase Effectors","HIV Infection","Signaling by VEGF","Generic Transcription Pathway","Regulation of mitotic cell cycle","Leishmania infection","FLT3 signaling in disease","Phospholipid m
etabolism","Neurotransmitter receptors and postsynaptic signal transmission","DAG and IP3 signaling","Mitotic G2-G2/M phases","Mitotic G1 phase and G1/S transition","Signaling by Type 1 Insulin-like G
rowth Factor 1 Receptor (IGF1R)","PIP3 activates AKT signaling","Signaling by Insulin receptor","Signaling by KIT in disease","Signaling by FGFR in disease","Axon guidance","Signaling by Interleukins"
,"Signaling by PDGFR in disease","TCR signaling","Caspase activation via extrinsic apoptotic signalling pathway","M Phase","Oncogenic MAPK signaling","Hedgehog 'on' state","IRE1alpha activates chapero
nes","Signaling by MST1","mTORC1-mediated signalling","Selective autophagy","Glycogen metabolism","Signaling by TGF-beta Receptor Complex in Cancer","Homology Directed Repair","MAPK1/MAPK3 signaling",
"Apoptotic execution phase","Interferon Signaling","rRNA processing in the nucleus and cytosol","Regulation of signaling by NODAL","Ion homeostasis","Sphingolipid metabolism","Signaling by WNT in canc
er","Pyruvate metabolism and Citric Acid (TCA) cycle","Anchoring of the basal body to the plasma membrane","Signaling by NOTCH1 in Cancer","p75 NTR receptor-mediated signalling","GPCR ligand binding",
"Signaling by SCF-KIT","Signaling by PTK6","Fcgamma receptor (FCGR) dependent phagocytosis","Neutrophil degranulation","Response of EIF2AK4 (GCN2) to amino acid deficiency","Cell-extracellular matrix 
interactions","Nitric oxide stimulates guanylate cyclase","Signaling by FGFR","Signaling by BMP","Disorders of Nervous System Development","Regulation of lipid metabolism by PPARalpha","Clathrin-media
ted endocytosis","Stimuli-sensing channels","PI3K/AKT Signaling in Cancer","Metabolism of steroids","Beta-catenin independent WNT signaling","MAPK6/MAPK4 signaling","Influenza Infection","tRNA Aminoac
ylation","Fc epsilon receptor (FCERI) signaling","trans-Golgi Network Vesicle Budding","Phase I - Functionalization of compounds","Signaling by ERBB2","G2/M Checkpoints","ESR-mediated signaling","Telo
mere Maintenance","Costimulation by the CD28 family","Response to elevated platelet cytosolic Ca2+","Oxidative Stress Induced Senescence","SARS-CoV-1 Infection","G alpha (q) signalling events","Signal
ing by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) Cascade","RHO GTPases activate PAKs","Host Interactions of HIV factors","VEGFA-VEGFR2 Pathway","Transcriptional Regulation by TP53","APC/C-mediated de
gradation of cell cycle proteins","Parasite infection","Signaling by FLT3 ITD and TKD mutants","PI Metabolism","Activation of NMDA receptors and postsynaptic events","CaM pathway","Leishmania parasite
 growth and survival","G2/M Transition","G0 and Early G1","IGF1R signaling cascade","Glutamate binding","activation of AMPA receptors and synaptic plasticity","PTEN Regulation","Insulin receptor signa
lling cascade","Drug resistance of KIT mutants","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AKT network","Signaling by FGFR3 in disease","Semaphorin interactions","Interleukin
-2 family signaling","Drug resistance of PDGFR mutants","Toll Like Receptor 4 (TLR4) Cascade","Generation of second messenger molecules","Caspase activation via Dependence Receptors in the absence of 
ligand","Mitotic Metaphase and Anaphase","Transcriptional regulation by RUNX1","Signaling by RAS mutants",Mitophagy,"Toll Like Receptor 2 (TLR2) Cascade","G alpha (i) signalling events","EPH-Ephrin si
gnaling","HIV Life Cycle","Glycogen breakdown (glycogenolysis)","Signaling by FGFR2 in disease","Signaling by ROBO receptors","Loss of Function of SMAD2/3 in Cancer","HDR through Homologous Recombinat
ion (HRR) or Single Strand Annealing (SSA)","RAF/MAP kinase cascade","Apoptotic cleavage of cellular proteins","Antiviral mechanism by IFN-stimulated genes","Major pathway of rRNA processing in the nu
cleolus and cytosol","RHO GTPases activate PKNs","Sphingolipid de novo biosynthesis","G1 Phase","Signaling by AMER1 mutants","Pyruvate metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","S
ignaling by NOTCH1 HD+PEST Domain Mutants in Cancer","RHO GTPases activate CIT","G alpha (s) signalling events","p75NTR signals via NF-kB","Mitotic Prophase","RET signaling","Class A/1 (Rhodopsin-like
 receptors)","Signaling by NTRK3 (TRKC)","Interferon alpha/beta signaling","PTK6 promotes HIF1A stabilization","Role of phospholipids in phagocytosis","G alpha (z) signalling events","Signaling by FGF
R1 in disease","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","cGMP effects","Signaling by FGFR4","L1CAM interactions","Pervasive developmental disorders","PPARA 
activates gene expression","Transcriptional Regulation by VENTX","Cargo recognition for clathrin-mediated endocytosis","Constitutive Signaling by AKT1 E17K in Cancer","Interleukin-1 family signaling",
"Bile acid and bile salt metabolism","Ca2+ pathway","PTK6 Down-Regulation","NS1 Mediated Effects on Host Pathways","Cytosolic tRNA aminoacylation","FCERI mediated Ca+2 mobilization","Golgi Associated 
Vesicle Biogenesis","Ethanol oxidation","Downregulation of ERBB2 signaling","G2/M DNA damage checkpoint","Extra-nuclear estrogen signaling","FOXO-mediated transcription","Cytochrome P450 - arranged by
 substrate type","Extension of Telomeres","CD28 co-stimulation","G1/S Transition","Platelet degranulation","SARS-CoV-1 Genome Replication and Transcription","Gastrin-CREB signalling pathway via PKC an
d MAPK","Signalling to ERKs","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","VEGFR2 mediated cell proliferation","Regulation of TP53 Activ
ity","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Leishmania phagocytosis","STAT5 activation downstream of FLT3 ITD mutants","Synthesis of PIPs at the plasma membran
e","Post NMDA receptor activation events","Calmodulin induced events","Anti-inflammatory response favouring Leishmania parasite infection","Centrosome maturation","IRS-related events triggered by IGF1
R","Trafficking of AMPA receptors","Regulation of PTEN stability and activity","IRS-mediated signalling","Dasatinib-resistant KIT mutants","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"
PP2A and IER3 Regulate PI3K/AKT Signaling","Signaling by FGFR3 point mutants in cancer","Sema4D in semaphorin signaling","Interleukin-15 signaling","Imatinib-resistant PDGFR mutants","MyD88-independen
t TLR4 cascade","Mitotic Anaphase","RUNX1 regulates transcription of genes involved in BCR signaling","Signaling downstream of RAS mutants","Receptor Mediated Mitophagy","TP53 Regulates Transcription 
of DNA Repair Genes","Toll Like Receptor TLR6:TLR2 Cascade","Visual phototransduction","EPHA-mediated growth cone collapse","Late Phase of HIV Life Cycle","FGFR2 mutant receptor activation","Activatio
n of RAC1","Ephrin signaling","SMAD2/3 Phosphorylation Motif Mutants in Cancer","HDR through Homologous Recombination (HRR)","Negative regulation of MAPK pathway","ISG15 antiviral mechanism","Activate
d PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","RAS processing","Cyclin D associated events in G1","Truncations of AMER1 destabilize the destruction complex",
"Regulation of pyruvate dehydrogenase (PDH) complex","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Signalling to ERK5","p75NTR recruits signalling complexes","Nuclear Envelope Breakdown",
"Amine ligand-binding receptors","Activation of TRKA receptors","Activated NTRK3 signals through PI3K","Interleukin-2 signaling","Regulation of IFNA signaling","EPHB-mediated forward signaling","FGFR1
 mutant receptor activation","Downstream signaling of activated FGFR4","Recycling pathway of L1","Loss of function of MECP2 in Rett syndrome","Synthesis of PIPs at the Golgi membrane","Role of ABL in 
ROBO-SLIT signaling","Negative regulation of FGFR4 signaling","CRMPs in Sema3A signaling","Interleukin-1 signaling","Synthesis of bile acids and bile salts","Inhibition of PKR","SEMA3A-Plexin repulsio
n signaling by inhibiting Integrin adhesion","Assembly and cell surface presentation of NMDA receptors","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Estrogen-stimulated signaling 
through PRKCZ","FOXO-mediated transcription of oxidative stress","metabolic and neuronal genes","Endogenous sterols","Telomere Extension By Telomerase","CD28 dependent PI3K/Akt signaling","Cyclin E as
sociated events during G1/S transition","Replication of the SARS-CoV-1 genome","EGFR Transactivation by Gastrin","Prolonged ERK activation events","MAP kinase activation","Nef-mediates down modulation
 of cell surface receptors by recruiting them to clathrin adapters","Regulation of TP53 Expression and Degradation","APC/C:Cdc20 mediated degradation of mitotic proteins","FCGR3A-mediated phagocytosis
","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","PKA-mediated phosphorylation of CREB","ADORA2B mediated anti-inflammatory cytokines production","Loss of proteins 
required for interphase microtubule organization from the centrosome","Trafficking of GluR2-containing AMPA receptors","FCGR3A-mediated IL10 synthesis","PI3K Cascade","FGFR3 mutant receptor activation
","Regulation of TP53 Activity through Phosphorylation","Sema4D mediated inhibition of cell attachment and migration","TRIF(TICAM1)-mediated TLR4 signaling","Separation of Sister Chromatids","Sema4D i
nduced cell migration and growth-cone collapse","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","The phototransduction cascade","Signalling to RAS","Transcription of the HIV genome","Nef and s
ignal transduction","Activated point mutants of FGFR2","Activation of RAC1 downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","Negative feedback regulation of MAPK pathway","Regulation
 of TP53 Activity through Acetylation","Activation of AMPK downstream of NMDARs","Long-term potentiation","Activation of NIMA Kinases NEK9",NEK6,NEK7,"CD163 mediating an anti-inflammatory response","M
uscarinic acetylcholine receptors","NGF-independant TRKA activation","Depolymerisation of the Nuclear Lamina","Signaling by activated point mutants of FGFR1","FRS-mediated FGFR4 signaling","Loss of ph
osphorylation of MECP2 at T308","Spry regulation of FGF signaling","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","Signaling by cytosolic FGFR1 fusion mutants","Phosphorylation
 of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes","Frs2-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","Regula
tion of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","RSK activation","PKA activation","Loss of Nlp from mitotic centroso
mes","Signaling by activated point mutants of FGFR3","IKK complex recruitment mediated by RIP1",Inactivation,"recovery and regulation of the phototransduction cascade","p38MAPK events","HIV Transcript
ion Elongation","activated TAK1 mediates p38 MAPK activation","Ras activation upon Ca2+ influx through NMDA receptor","Presynaptic phase of homologous DNA pairing and strand exchange","JNK (c-Jun kina
ses) phosphorylation and  activation mediated by activated human TAK1","PI5P Regulates TP53 Acetylation","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Acti
vation of IRF3/IRF7 mediated by TBK1/IKK epsilon","PKB-mediated events","ERK/MAPK targets","CREB phosphorylation","APC-Cdc20 mediated degradation of Nek2A","Activation of the AP-1 family of transcript
ion factors","Tat-mediated elongation of the HIV-1 transcript","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","PDE3B signalling","ERKs are inactivated","Formation of HIV-1 elongation complex c
ontaining HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{staurosporine,Staurosporin,62996-74-1,62996741,(+)-Staurosporine,(+)Staurosporine,"Antibiotic 230","Antibiotic AM 2282",AM-2282,AM2282,"CCRIS 3272","Antibiotic AM-2282","Antibiotic AM2282",UNII-H88EP
A0A3N,UNIIH88EPA0A3N,"Alkaloid AM-2282 from Streptomyces","Alkaloid AM2282 from Streptomyces",H88EPA0A3N,CHEMBL388978,CHEBI:15738,GNF-PF-1389,GNFPF1389,meth,STAUROSPORINE}

> <pdid>
PD003511

> <targets>
{NULL,PKA,PKG,PKC}

> <classes>
{}

> <pubchem_cids>
{44259}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 22  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7554    0.0000 C   0  0
   -3.8938   -2.2554    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -5.2029    2.9932    0.0000 O   0  0
   -6.4990    0.7409    0.0000 N   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0994    0.7387    0.0000 C   0  0
  -10.3984    1.4886    0.0000 C   0  0
  -10.3985    2.9886    0.0000 C   0  0
   -9.0995    3.7387    0.0000 C   0  0
   -7.8004    2.9887    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  5  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  3  0
 10 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28102

> <plate>
Kinase v5-1

> <well>
C13

> <supplier_cmpd_name>
AG-494

> <ctcr_id>
7673

> <supplier_cmpd_id>
EI-228

> <smiles>
Oc1ccc(cc1O)\C=C(C#N)\C(=O)Nc2ccccc2

> <pd_targets>
{HIF1A,EGFR,HSD17B10,KDM4E,SMN1,RORC,ALOX12,CYP2D6,CYP3A4,CYP1A2,PSMD14,KMT2A,MAPT,GRIN1,GRIN2B,MEN1,NFKB1,ALOX15,HPGD,TP53,ERBB2,ALDH1A1,MAPK1,F2,GMNN,LMNA,PMP22,BLM,CHRM1,PDGFRB,PKM,ALD,PYK,FTL,CYP2
C19,LEF}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator","Other cytosolic protein","Ion channel","Unclassified protein","Other nuclear protein","Membrane receptor",Kinase,Oxidoreductase,Eraser,Reader,"Nu
clear receptor","Cytochrome P450",Protease,"Ligand-gated ion channel","Family A G protein-coupled receptor",Transferase,"Protein Kinase","Lysine demethylase","Methyl-lysine/arginine binding protein","
Nuclear hormone receptor subfamily 1","Cytochrome P450 family 2","Cytochrome P450 family 3","Cytochrome P450 family 1","Metallo protease",Bromodomain,"Ionotropic glutamate receptor","Serine protease",
"Small molecule receptor (family A GPCR)","TK protein kinase group","Jumonji domain-containing","Tudor domain","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 2D","Cytochrome P4
50 family 3A","Cytochrome P450 family 1A","Metallo protease MP clan","NMDA receptor","CMGC protein kinase group","Serine protease PA clan","Monoamine receptor","Cytochrome P450 family 2C","Metallo pro
tease MAE clan","Tyrosine protein kinase EGFR family","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 2D6","Cytochrome P450 3A4","Cytochrome P450 1A1","Metallo protease M67 fa
mily","CMGC protein kinase MAPK family","Serine protease S1A subfamily","Acetylcholine receptor","Tyrosine protein kinase PDGFR family","Cytochrome P450 2C19","Metallo protease M34 family","Metallo pr
otease M67A subfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Chromatin modifying enzymes","Nuclear hormone receptors","Eicosanoid turnover","Cytochrome P450","Peptidases and proteinases","Kinases (EC 2.7.x.x)","G protei
n-coupled receptors","2.7.1.40 Pyruvate kinases","Receptor kinases","1.14.11.- Histone demethylases","1F. Retinoic acid-related orphans",Lipoxygenases,"CYP2 family: drug metabolising subset","CYP3 fam
ily","CYP1 family","MP: Metallo (M) Peptidases","2.1.1.43 Histone methyltransferases (HMTs)","Prostaglandin synthases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","PA: Serine (S) Peptidases","Acet
ylcholine receptors (muscarinic)","TK: Tyrosine kinase","M67: PSMD14 peptidase","Mitogen-activated protein kinases (MAP kinases)","S1: Chymotrypsin","Receptor tyrosine kinases (RTKs)","ERK subfamily",
"Type I RTKs: ErbB (epidermal growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Cellular responses to external stimuli","Signal Transduction",Metabolism,"Metabolism of RNA","Gene expression (Transcription)","Cell Cycle","Neuronal System","Immune System","Developmental Biology",
Disease,"DNA Repair","Vesicle-mediated transport","Cellular responses to stress","Signaling by GPCR","Metabolism of amino acids and derivatives","Metabolism of non-coding RNA","RNA Polymerase II Trans
cription","Metabolism of lipids","Biological oxidations",Mitotic,"Transmission across Chemical Synapses","Cytokine Signaling in Immune system","Cell Cycle Checkpoints","Nervous system development","In
nate Immune System","Diseases of hemostasis","DNA Double-Strand Break Repair","Intracellular signaling by second messengers","Metabolism of carbohydrates","Membrane Trafficking","Infectious disease","
Cellular response to hypoxia","GPCR downstream signalling","Branched-chain amino acid catabolism","snRNP Assembly","Generic Transcription Pathway","Biosynthesis of specialized proresolving mediators (
SPMs)","Phase I - Functionalization of compounds","Regulation of mitotic cell cycle","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by Interleukins","G1/S DNA Damage Chec
kpoints","Axon guidance","Toll-like Receptor Cascades","Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)","Mitotic G1 phase and G1/S transition","M Phase","EGR2 and SOX10-m
ediated initiation of Schwann cell myelination","Homology Directed Repair","GPCR ligand binding","PIP3 activates AKT signaling","Glucose metabolism","trans-Golgi Network Vesicle Budding","Uptake and a
ctions of bacterial toxins","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","G alpha (q) signalling events","Transcriptional regulation by RUNX3","Biosynthesis of DPA-derive
d SPMs","Cytochrome P450 - arranged by substrate type","Biosynthesis of DHA-derived SPMs","APC/C-mediated degradation of cell cycle proteins","Transcriptional regulation by RUNX1","Activation of NMDA 
receptors and postsynaptic events","Interleukin-1 family signaling","p53-Dependent G1/S DNA damage checkpoint","Semaphorin interactions","Ethanol oxidation","Toll Like Receptor 5 (TLR5) Cascade","Defe
ctive factor VIII causes hemophilia A","G1/S Transition","Mitotic Metaphase and Anaphase","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Class A/1 (Rhodopsin-like recep
tors)","Negative regulation of the PI3K/AKT network",Glycolysis,"Golgi Associated Vesicle Biogenesis","Uptake and function of anthrax toxins","Gastrin-CREB signalling pathway via PKC and MAPK","RUNX3 
Regulates Immune Response and Cell Migration","Biosynthesis of DPAn-3 SPMs",Xenobiotics,"Biosynthesis of maresins","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","RUNX1
 regulates genes involved in megakaryocyte differentiation and platelet function","Post NMDA receptor activation events","Interleukin-1 signaling","Biosynthesis of D-series resolvins","p53-Dependent G
1 DNA Damage Response","Sema4D in semaphorin signaling","MyD88 cascade initiated on plasma membrane","Defective F8 cleavage by thrombin","Activation of the pre-replicative complex","Mitotic Anaphase",
"HDR through Homologous Recombination (HRR)","Amine ligand-binding receptors",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","EGFR Transactivation by Gastrin","Biosynthesis of DPAn-3-derived maresin
s","CYP2E1 reactions","Biosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","APC/C:Cdc20 mediated degradation of mitotic proteins","Activation of AMPK 
downstream of NMDARs","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of DPAn-3-derived protectins and resolvins","Stabilization of p53","Sema4D induced cell migration and growth-cone colla
pse","MAP kinase activation","Nuclear Envelope (NE) Reassembly","Homologous DNA Pairing and Strand Exchange","Muscarinic acetylcholine receptors","APC:Cdc20 mediated degradation of cell cycle proteins
 prior to satisfation of the cell cycle checkpoint","Autodegradation of the E3 ubiquitin ligase COP1","MAPK targets/ Nuclear events mediated by MAP kinases","Initiation of Nuclear Envelope (NE) Reform
ation","Presynaptic phase of homologous DNA pairing and strand exchange","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{3355035,133550-35-3,133550353,"Tyrphostin B48","AG 494","Tyrphostin AG 494",AG-494,AG494,"(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide","(E)2cyano3(3,4dihydroxyphenyl)Nphenylacrylamide","al
pha-Cyano-(3,4-dihydroxy)-N-phenylcinnamide","alphaCyano(3,4dihydroxy)Nphenylcinnamide",139087-53-9,139087539,CHEMBL56731,(E)-2-CYANO-3-(3,(E)2CYANO3(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-P,4DIHYDROXYPHENYL
)NPHENYL2P,EI-228}

> <pdid>
PD015005

> <targets>
{EGFRK,PDGFRK}

> <classes>
{}

> <pubchem_cids>
{5328771}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
    2.5490  -12.2198    0.0000 C   0  0
    1.7972  -10.9218    0.0000 O   0  0
    2.5450   -9.6205    0.0000 C   0  0
    4.0450   -9.6205    0.0000 C   0  0
    4.7951   -8.3215    0.0000 C   0  0
    4.0452   -7.0225    0.0000 C   0  0
    2.5451   -7.0223    0.0000 C   0  0
    1.7974   -5.7210    0.0000 C   0  0
    2.5497   -4.4224    0.0000 S   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.7951   -8.3214    0.0000 C   0  0
    0.2951   -8.3214    0.0000 O   0  0
    6.2959   -8.3185    0.0000 C   0  0
    7.0445   -7.0177    0.0000 C   0  0
    8.5454   -7.0147    0.0000 C   0  0
   10.0454   -7.0117    0.0000 N   0  0
    6.2946   -5.7177    0.0000 C   0  0
    4.7946   -5.7176    0.0000 N   0  0
    7.0442   -4.4185    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 17 18  1  0
 18 10  2  0
  7 19  2  0
 19  3  1  0
 19 20  1  0
  5 21  1  0
 21 22  2  3
 22 23  1  0
 23 24  3  0
 22 25  1  0
 25 26  1  0
 25 27  2  0
M  END
> <name>
UTKinase_V5

> <id>
28103

> <plate>
Kinase v5-1

> <well>
C15

> <supplier_cmpd_name>
AG-825

> <ctcr_id>
1885

> <supplier_cmpd_id>
EI-267

> <smiles>
COc1cc(cc(CSc2sc3ccccc3n2)c1O)C=C(C#N)C(N)=O

> <pd_targets>
{EGFR,MAPT,TP53,ERBB2,ALDH1A1,CYP2D6,CYP1A2,HSD17B10,CYP2C19,HPGD,RORC,CYP3A4,FTL,KMT2A,MEN1,LEF}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Transcription factor","Unclassified protein","Epigenetic regulator",Kinase,Oxidoreductase,"Cytochrome P450","Nuclear receptor",Reader,Protease,"Protein Kinase","Cyto
chrome P450 family 2","Cytochrome P450 family 1","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3",Bromodomain,"Metallo protease","TK protein kinase group","Cytochrome P450 family 2D",
"Cytochrome P450 family 1A","Cytochrome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 3A","Metallo protease MAE clan","Tyrosine protein kinase EGFR family","Cy
tochrome P450 2D6","Cytochrome P450 1A1","Cytochrome P450 2C19","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 3A4","Metallo protease M34 family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Cytochrome P450","Eicosanoid turnover","Nuclear hormone receptors","Receptor kinases","CYP2 family: drug metabolising subset","CYP1 family","Prostaglandin syn
thases","1F. Retinoic acid-related orphans","CYP3 family","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System","Cell Cycle","Developmental Biology",Metabolism,"Gene expression (Transcription)","Vesicle-mediated transport",Disease,"Signaling by GPCR","Transmission across
 Chemical Synapses","Cell Cycle Checkpoints","Nervous system development","Biological oxidations","Metabolism of amino acids and derivatives","Metabolism of lipids","RNA Polymerase II Transcription","
Membrane Trafficking","Infectious disease","GPCR downstream signalling","Neurotransmitter receptors and postsynaptic signal transmission","G1/S DNA Damage Checkpoints","Axon guidance","Phase I - Funct
ionalization of compounds","Branched-chain amino acid catabolism","Biosynthesis of specialized proresolving mediators (SPMs)","Generic Transcription Pathway","trans-Golgi Network Vesicle Budding","Upt
ake and actions of bacterial toxins","G alpha (q) signalling events","Activation of NMDA receptors and postsynaptic events","p53-Dependent G1/S DNA damage checkpoint","Semaphorin interactions","Ethano
l oxidation","Cytochrome P450 - arranged by substrate type","Biosynthesis of DHA-derived SPMs","Transcriptional regulation by RUNX3","Golgi Associated Vesicle Biogenesis","Uptake and function of anthr
ax toxins","Gastrin-CREB signalling pathway via PKC and MAPK","Post NMDA receptor activation events","p53-Dependent G1 DNA Damage Response","Sema4D in semaphorin signaling",Xenobiotics,"Biosynthesis o
f D-series resolvins","RUNX3 Regulates Immune Response and Cell Migration","Biosynthesis of maresins","EGFR Transactivation by Gastrin","Activation of AMPK downstream of NMDARs","Stabilization of p53"
,"Sema4D induced cell migration and growth-cone collapse","CYP2E1 reactions","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of maresin-like SPMs","Autodegradation of 
the E3 ubiquitin ligase COP1"}

> <broad_targets>
{ERBB2}

> <broad_moa>
{"protein tyrosine kinase inhibitor"}

> <synonyms>
{G82,"Tyrphostin AG-825","Tyrphostin AG825",KBioGR_000522,KBioGR000522,KBioGR-000522,"KBioGR 000522",KBioSS_000522,KBioSS000522,KBioSS-000522,"KBioSS 000522",SCHEMBL1704700,KBio2_000522,KBio2000522,KB
io2-000522,"KBio2 000522",KBio2_003090,KBio2003090,KBio2-003090,"KBio2 003090",KBio2_005658,KBio2005658,KBio2-005658,"KBio2 005658",KBio3_000943,KBio3000943,KBio3-000943,"KBio3 000943",KBio3_000944,KB
io3000944,KBio3-000944,"KBio3 000944",Bio2_000431,Bio2000431,Bio2-000431,"Bio2 000431",Bio2_000911,Bio2000911,Bio2-000911,"Bio2 000911",DTXSID201017143,HMS3268E11,DB-082050,DB082050,FT-0697721,FT06977
21,Q27163924,EI-267,AG-825}

> <pdid>
PD019583

> <targets>
{HER1-2}

> <classes>
{}

> <pubchem_cids>
{2062}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
    2.6030   -2.9977    0.0000 O   0  0
    2.6003   -1.4977    0.0000 C   0  0
    3.4657   -0.9965    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -0.0020    3.0008    0.0000 N   0  0
   -1.3030    3.7490    0.0000 C   0  0
   -2.6020    2.9972    0.0000 C   0  0
   -2.5975    1.4972    0.0000 C   0  0
   -3.8942    0.7432    0.0000 C   0  0
   -5.1955    1.4892    0.0000 C   0  0
   -5.2002    2.9892    0.0000 C   0  0
   -3.9034    3.7432    0.0000 C   0  0
   -3.9081    5.2432    0.0000 O   0  0
    1.2969    3.7525    0.0000 C   0  0
    2.5979    3.0043    0.0000 C   0  0
    2.5975    1.5042    0.0000 C   0  0
    3.8962    0.7537    0.0000 C   0  0
    3.8959   -0.2463    0.0000 O   0  0
    5.1955    1.5033    0.0000 C   0  0
    5.1961    3.0033    0.0000 C   0  0
    3.8973    3.7538    0.0000 C   0  0
    3.8979    5.2538    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
  6 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 11 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 23 25  2  0
 25 26  1  0
 26 27  2  0
 27 21  1  0
 27 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28104

> <plate>
Kinase v5-1

> <well>
C17

> <supplier_cmpd_name>
Lavendustin A

> <ctcr_id>
1307

> <supplier_cmpd_id>
EI-185

> <smiles>
OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3cc(O)ccc3O

> <pd_targets>
{KMT2A,MEN1,MAPT,LCK,FFP,ALDH1A1,EGFR,TDP1,HPGD}

> <pathway_gtopdb>
{"Epigenetic regulator","Other cytosolic protein",Enzyme,Reader,Kinase,Transferase,Oxidoreductase,Hydrolase,Bromodomain,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Src family",
"Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Eicosanoid turnover","Receptor kinases","Prostaglandin synthases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RT
Ks)","Src family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Neuronal System",Disease,Metabolism,"Signal Transduction","DNA Repair","Transmission across Chemical Synapses","Infectious disease","Biological oxidations","Signaling by GPCR","DNA Double-Strand Bre
ak Repair","Metabolism of lipids","Neurotransmitter receptors and postsynaptic signal transmission","HIV Infection","Phase I - Functionalization of compounds","GPCR downstream signalling","Nonhomologo
us End-Joining (NHEJ)","Biosynthesis of specialized proresolving mediators (SPMs)","Activation of NMDA receptors and postsynaptic events","Host Interactions of HIV factors","Ethanol oxidation","G alph
a (q) signalling events","Biosynthesis of DHA-derived SPMs","Post NMDA receptor activation events","The role of Nef in HIV-1 replication and disease pathogenesis","Gastrin-CREB signalling pathway via 
PKC and MAPK","Biosynthesis of D-series resolvins","Activation of AMPK downstream of NMDARs","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","EGFR Tran
sactivation by Gastrin","Nef Mediated CD4 Down-regulation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Lavendustin A",125697-92-9,125697929,RG14355,UNII-3Y0G32G2RV,UNII3Y0G32G2RV,RG-14355,3Y0G32G2RV,CHEMBL103552,"RG 14355","5-((2,5-dihydroxybenzyl)(2-hydroxybenzyl)amino)-2-hydroxybenzoic acid","5((2,
5dihydroxybenzyl)(2hydroxybenzyl)amino)2hydroxybenzoic acid","Lavendustin A, from Streptomyces griseolavendus",LAVENDUSTINA,BiomolKI_00,BiomolKI00,BiomolKI-00,"BiomolKI 00",T4183,EI-185,"lavendustin A
"}

> <pdid>
PD040726

> <targets>
{EGFRK}

> <classes>
{}

> <pubchem_cids>
{3894}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.2940   -3.7521    0.0000 C   0  0
    0.0063   -4.4998    0.0000 N   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 N   0  0
   -5.1925   -3.0071    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  7  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  3  0
 10 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28105

> <plate>
Kinase v5-1

> <well>
C19

> <supplier_cmpd_name>
RG-1462

> <ctcr_id>
7675

> <supplier_cmpd_id>
EI-253

> <smiles>
Clc1cc(Cl)cc(c1)/C=C(C#N)/c2cccnc2

> <pd_targets>
{MAPT}

> <pathway_gtopdb>
{"Other cytosolic protein"}

> <pathway_chembl>
{}

> <pathway_reactome>
{"Neuronal System","Transmission across Chemical Synapses","Neurotransmitter receptors and postsynaptic signal transmission","Activation of NMDA receptors and postsynaptic events","Post NMDA receptor 
activation events","Activation of AMPK downstream of NMDARs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NIIY42W2Q9ZP,UNII-Y42W2Q9ZPP,UNIIY42W2Q9ZPP,Y42W2Q9ZPP,RG-14620,RG14620,rg14620,BRD3356,BRD-3356,BiomolKI_000010,BiomolKI000010,BiomolKI-000010,"BiomolKI 000010","Tyrphostin RG-14620","Tyrphostin RG1
4620",BiomolKI2_000020,BiomolKI2000020,BiomolKI2-000020,"BiomolKI2 000020",BSPBio_001154,BSPBio001154,BSPBio-001154,"BSPBio 001154",SCHEMBL240907,BMK1-B10,BMK1B10,SCHEMBL1527748,CHEMBL1555142,BCBcMAP0
1_000206,BCBcMAP01000206,BCBcMAP01-000206,"BCBcMAP01 000206",(Z)-3-(3,(Z)3(3,5-dichlorophenyl)-2-pyridin-3-,5dichlorophenyl)2pyridin3,EI-253,RG-1462}

> <pdid>
PD020216

> <targets>
{EGFRK}

> <classes>
{}

> <pubchem_cids>
{5926218}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 14  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.5009    2.2405    0.0000 N   0  0
   -3.8964   -0.7554    0.0000 C   0  0
   -3.8938   -2.2554    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  5  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  3  0
 10 13  1  0
 13 14  3  0
M  END
> <name>
UTKinase_V5

> <id>
28106

> <plate>
Kinase v5-1

> <well>
C21

> <supplier_cmpd_name>
TYRPHOSTIN 23

> <ctcr_id>
1322

> <supplier_cmpd_id>
EI-191

> <smiles>
Oc1ccc(cc1O)C=C(C#N)C#N

> <pd_targets>
{KDM4E,SMN1,HIF1A,AMPC,CYP3A4,CYP19A1,KMT2A,MEN1,HSD17B10,ALDH1A1,EGFR,ALPL,TSHR,RORC,PMP22,ALD,L3MBTL1,ALPI,PTK2B,TP53,CYP2D6,THPO,CCNE1,CDK2,LMNA,MAPT,TGR,FFP,BLM,NFKB1,CYP2C19,CYP2C9,AKR1B1,NS1,HPG
D,KDM4C,CYP1A2,IMPA1,ALOX15,MAPK1,ALOX12}

> <pathway_gtopdb>
{"Epigenetic regulator","Transcription factor",Enzyme,"Membrane receptor","Unclassified protein","Other nuclear protein","Other cytosolic protein",Eraser,Reader,Hydrolase,"Cytochrome P450",Oxidoreduct
ase,Kinase,Phosphatase,"Family A G protein-coupled receptor","Nuclear receptor",Transferase,"Lysine demethylase","Methyl-lysine/arginine binding protein","Cytochrome P450 family 3","Cytochrome P450 fa
mily 19",Bromodomain,"Protein Kinase","Peptide receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 2","Cytochrome P450 family 1","Jumonji domain-containing","Tudor
 domain","Cytochrome P450 family 3A","Cytochrome P450 family 19A","TK protein kinase group","Glycohormone receptor","Nuclear hormone receptor subfamily 1 group F","MBT domain","Cytochrome P450 family 
2D","CMGC protein kinase group","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Cytochrome P450 3A4","Cytochrome P450 19A1","Tyrosine protein kinase EGFR family","Nuclear hormone receptor sub
family 1 group F member 3","Tyrosine protein kinase Fak family","Cytochrome P450 2D6","CMGC protein kinase CDK family","Cytochrome P450 2C19","Cytochrome P450 2C9","Cytochrome P450 1A1","CMGC protein 
kinase MAPK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Chromatin modifying enzymes","Cytochrome P450","Catalytic receptors","G protein-coupled receptors","Nuclear hormone receptors","1.-.-.- Oxidoreductases","Eicosanoid turnover","Inos
itol phosphate turnover","Kinases (EC 2.7.x.x)","1.14.11.- Histone demethylases","CYP3 family",CYP11,CYP17,CYP19,"CYP20 and CYP21 families","Receptor kinases","Glycoprotein hormone receptors","1F. Ret
inoic acid-related orphans","CYP2 family: drug metabolising subset","Prostaglandin synthases","CYP1 family","Inositol monophosphatase",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK
: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","Type I RTKs: ErbB (epidermal growth fac
tor) receptor family","Fak family"}

> <pathway_reactome>
{"Metabolism of RNA","Cellular responses to external stimuli",Metabolism,"Signal Transduction","Metabolism of proteins",Disease,"Gene expression (Transcription)","Developmental Biology","Immune System
","Cell Cycle",Hemostasis,"Neuronal System","DNA Repair","Metabolism of non-coding RNA","Cellular responses to stress","Metabolism of lipids","Biological oxidations","Metabolism of amino acids and der
ivatives","Signaling by GPCR","Post-translational protein modification","Infectious disease","RNA Polymerase II Transcription","Nervous system development","Cytokine Signaling in Immune system","Cell 
Cycle Checkpoints","Platelet activation","signaling and aggregation",Mitotic,"Transmission across Chemical Synapses","DNA Double-Strand Break Repair","Signaling by Rho GTPases","Inositol phosphate met
abolism","Innate Immune System","snRNP Assembly","Cellular response to hypoxia","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","Branched-chain a
mino acid catabolism","GPCR downstream signalling","Post-translational modification: synthesis of GPI-anchored proteins","Leishmania infection","Generic Transcription Pathway","EGR2 and SOX10-mediated
 initiation of Schwann cell myelination","Signaling by Interleukins","G1/S DNA Damage Checkpoints","Phospholipid metabolism","Platelet Aggregation (Plug Formation)","M Phase","Neurotransmitter recepto
rs and postsynaptic signal transmission","Homology Directed Repair","Metabolism of steroids","RHO GTPase Effectors","Synthesis of IP2",IP,"and Ins in the cytosol","Toll-like Receptor Cascades","Oxygen
-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Ethanol oxidation","G alpha (q) signalling events
","Leishmania parasite growth and survival","Transcriptional regulation by RUNX3","Transcriptional Regulation by TP53","Interleukin-2 family signaling","p53-Dependent G1/S DNA damage checkpoint","Glyc
erophospholipid biosynthesis","Mitotic Metaphase and Anaphase","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Int
erleukin-1 family signaling","Metabolism of steroid hormones","RHO GTPases activate PKNs","Biosynthesis of DPA-derived SPMs","Toll Like Receptor 5 (TLR5) Cascade","Biosynthesis of maresins","Endogenou
s sterols","Gastrin-CREB signalling pathway via PKC and MAPK","Anti-inflammatory response favouring Leishmania parasite infection","RUNX3 Regulates Immune Response and Cell Migration","Regulation of T
P53 Activity","Interleukin-2 signaling","p53-Dependent G1 DNA Damage Response",Xenobiotics,"Synthesis of PA","Mitotic Anaphase","Post NMDA receptor activation events","HDR through Homologous Recombina
tion (HRR)","Interleukin-1 signaling","Pregnenolone biosynthesis","Biosynthesis of D-series resolvins","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"
,"Biosynthesis of DPAn-3 SPMs","MyD88 cascade initiated on plasma membrane","Biosynthesis of maresin-like SPMs","EGFR Transactivation by Gastrin","ADORA2B mediated anti-inflammatory cytokines producti
on","Regulation of TP53 Activity through Methylation","Stabilization of p53","CYP2E1 reactions","Nuclear Envelope (NE) Reassembly","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and
 Strand Exchange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of DPAn-3-derived protectins and resolvins","MAP kinase 
activation","Biosynthesis of DPAn-3-derived maresins","Autodegradation of the E3 ubiquitin ligase COP1","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing a
nd strand exchange","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor","tyrosine kinase inhibitor"}

> <synonyms>
{"Tyrphostin 23",118409-57-7,118409577,"Tyrphostin A23","AG 18",RG-50810,RG50810,AG-18,AG18,"(3,4-Dihydroxybenzylidene)malononitrile","(3,4Dihydroxybenzylidene)malononitrile","2-(3,4-dihydroxybenzylid
ene)malononitrile","2(3,4dihydroxybenzylidene)malononitrile","2-((3,4-dihydroxyphenyl)methylidene)propanedinitrile","2((3,4dihydroxyphenyl)methylidene)propanedinitrile",ag18,Propanedinitrile,2-((3,2((
3,4,T2063,EI-191,S8009,"TYRPHOSTIN 23"}

> <pdid>
PD002603

> <targets>
{EGFRK,EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{2052}

$$$$
UTKinase_V5
  SciTegic11012413002D

 15 15  0  0  0  0            999 V2000
   -0.0034   -3.0047    0.0000 N   0  0
    1.2956   -3.7547    0.0000 C   0  0
    1.2951   -5.2547    0.0000 S   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1908   -4.5097    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 11 13  2  0
 13  6  1  0
  4 14  1  0
 14 15  3  0
M  END
> <name>
UTKinase_V5

> <id>
28107

> <plate>
Kinase v5-1

> <well>
E03

> <supplier_cmpd_name>
TYRPHOSTIN 47

> <ctcr_id>
5767

> <supplier_cmpd_id>
EI-188

> <smiles>
NC(=S)C(=Cc1ccc(O)c(O)c1)C#N

> <pd_targets>
{TSHR,NFKB1,HSD17B10,MAPT,ALDH1A1,FFP,TDP1,ALOX15,CHRM1,CYP3A4,CYP2D6,SYK,DNM1,EGFR,HIF1A,KMT2A,MEN1,ALOX12,CYP1A2,IMPA1,MAPK1,HPGD,RECQL,KDM4E,CYP2C19,CSF1R,ERBB2,TP53,BLM,GAA,CYP2C9,PKM,ALD,LEF,GLA,
LCK,FTL,POLB,PMP22,APEX1,NPSR1}

> <pathway_gtopdb>
{"Membrane receptor","Other cytosolic protein",Enzyme,"Transcription factor","Epigenetic regulator","Family A G protein-coupled receptor",Oxidoreductase,Transferase,Protease,Hydrolase,"Cytochrome P450
",Kinase,Reader,Eraser,"Peptide receptor (family A GPCR)","Cysteine protease","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Protein Kinase",Bromodoma
in,"Cytochrome P450 family 1","Lysine demethylase","Metallo protease","Glycohormone receptor","Cysteine protease CA clan","Monoamine receptor","Cytochrome P450 family 3A","Cytochrome P450 family 2D","
TK protein kinase group","Cytochrome P450 family 1A","CMGC protein kinase group","Jumonji domain-containing","Cytochrome P450 family 2C","Metallo protease MAE clan","Cysteine protease C1A family","Ace
tylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 2D6","Tyrosine protein kinase Syk family","Tyrosine protein kinase EGFR family","Cytochrome P450 1A1","CMGC protein kinase MAPK family","Cyt
ochrome P450 2C19","Tyrosine protein kinase PDGFR family","Cytochrome P450 2C9","Metallo protease M34 family","CMGC protein kinase ERK1","Tyrosine protein kinase Src family","Unclassified protein","Sh
ort peptide receptor (family A GPCR)","Neuropeptide receptor"}

> <pathway_chembl>
{Receptors,Enzymes,"G protein-coupled receptors","Eicosanoid turnover","Cytochrome P450","Catalytic receptors","Inositol phosphate turnover","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","3.2.1
.- Glycosidases","2.7.1.40 Pyruvate kinases","Glycoprotein hormone receptors",Lipoxygenases,"Acetylcholine receptors (muscarinic)","CYP3 family","CYP2 family: drug metabolising subset","Receptor kinas
es","CYP1 family","Inositol monophosphatase","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglandin synthases","1.14.11.- Histone demethylases","TK: Tyrosine kinase","Mitogen-activated protein
 kinases (MAP kinases)","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","ERK subfamily","Syk family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type III 
RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Src family","Neuropeptide S receptor"}

> <pathway_reactome>
{Disease,"Immune System",Metabolism,"Neuronal System","DNA Repair","Signal Transduction","Vesicle-mediated transport","Cellular responses to external stimuli","Gene expression (Transcription)","Develo
pmental Biology","Cell Cycle","Infectious disease","Cytokine Signaling in Immune system","Metabolism of amino acids and derivatives","Transmission across Chemical Synapses","Biological oxidations","DN
A Double-Strand Break Repair","Metabolism of lipids","Signaling by GPCR","Membrane Trafficking","Cellular responses to stress","Inositol phosphate metabolism","Innate Immune System","RNA Polymerase II
 Transcription","Nervous system development","Cell Cycle Checkpoints","Diseases of metabolism","Metabolism of carbohydrates","Leishmania infection","Signaling by Interleukins","Branched-chain amino ac
id catabolism","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization of compounds","Nonhomologous End-Joining (NHEJ)","Biosynthesis of specialized proresolving
 mediators (SPMs)","GPCR ligand binding","Gap junction trafficking and regulation","GPCR downstream signalling","Cellular response to hypoxia","Synthesis of IP2",IP,"and Ins in the cytosol","Toll-like
 Receptor Cascades","Generic Transcription Pathway","Axon guidance","G1/S DNA Damage Checkpoints","Homology Directed Repair","Diseases of carbohydrate metabolism","Glucose metabolism","Uptake and acti
ons of bacterial toxins","Sphingolipid metabolism","Leishmania parasite growth and survival","Interleukin-1 family signaling","Activation of NMDA receptors and postsynaptic events","Ethanol oxidation"
,"Biosynthesis of DPA-derived SPMs","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Gap junction trafficking","G alpha (q) sig
nalling events","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional Regulation by VENTX","Semaphorin interactions","p53-De
pendent G1/S DNA damage checkpoint","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Glycogen storage diseases",Glycolysis,"Uptake and function of anthrax toxins","Glycos
phingolipid metabolism","Anti-inflammatory response favouring Leishmania parasite infection","Interleukin-1 signaling","Post NMDA receptor activation events","Biosynthesis of DPAn-3 SPMs","Amine ligan
d-binding receptors","Biosynthesis of maresins",Xenobiotics,"Gap junction degradation","Gastrin-CREB signalling pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Biosynthesis of 
D-series resolvins","Sema4D in semaphorin signaling","p53-Dependent G1 DNA Damage Response","HDR through Homologous Recombination (HRR)","Glycogen storage disease type II (GAA)","ADORA2B mediated anti
-inflammatory cytokines production","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Activation of AMPK downstream of NMDARs","Biosynthesis of DPAn-3-derived protectins and resolvins","Muscarinic acetylc
holine receptors","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","FCGR3A-mediated IL10 synthesis","Formation of annular gap junctions","EGFR Transactivation by Gastrin","Biosynthesis of DPAn-3
-derived maresins","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP kinase activation","Sema4D induced cell migration and growth-cone collapse","Stabilization of p53","Homologou
s DNA Pairing and Strand Exchange","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","Presynaptic phase of homologous DNA pairing and strand exch
ange","ERK/MAPK targets","ERKs are inactivated","HIV Infection","Host Interactions of HIV factors","The role of Nef in HIV-1 replication and disease pathogenesis","Nef-mediates down modulation of cell
 surface receptors by recruiting them to clathrin adapters","Nef Mediated CD4 Down-regulation","Base Excision Repair","trans-Golgi Network Vesicle Budding","Resolution of Abasic Sites (AP sites)","EGR
2 and SOX10-mediated initiation of Schwann cell myelination","Golgi Associated Vesicle Biogenesis","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","PCNA-Dependent Long P
atch Base Excision Repair"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{"Tyrphostin 47","Tyrphostin AG 213",CHEMBL1408526,"RG 50864;Tyrphostin A 47","AG213;AG-213;AG 213","AG213;AG213;AG 213",122520-86-9,122520869,"RG 50864","(Z)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-ene
thioamide","(Z)2cyano3(3,4dihydroxyphenyl)prop2enethioamide",CBiol_002060,CBiol002060,CBiol-002060,"CBiol 002060",KBioGR_000112,KBioGR000112,KBioGR-000112,"KBioGR 000112",KBioSS_000112,KBioSS000112,KB
ioSS-000112,"KBioSS 000112",SCHEMBL1704818,KBio,EI-188,"TYRPHOSTIN 47"}

> <pdid>
PD014847

> <targets>
{EGFRK}

> <classes>
{}

> <pubchem_cids>
{3034797}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 20  0  0  0  0            999 V2000
    5.1937   -3.0093    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.2941   -3.7521    0.0000 C   0  0
   -0.0063   -4.4998    0.0000 N   0  0
    3.8912   -5.2578    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    6.4869   -6.7636    0.0000 N   0  0
    2.5901   -6.0060    0.0000 C   0  0
    1.2898   -6.7537    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  7  9  2  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 11 13  2  0
 13  5  1  0
  3 14  1  0
 14 15  3  0
  2 16  2  3
 16 17  1  0
 17 18  3  0
 16 19  1  0
 19 20  3  0
M  END
> <name>
UTKinase_V5

> <id>
28108

> <plate>
Kinase v5-1

> <well>
E05

> <supplier_cmpd_name>
TYRPHOSTIN 51

> <ctcr_id>
513

> <supplier_cmpd_id>
EI-189

> <smiles>
NC(C(=Cc1cc(O)c(O)c(O)c1)C#N)=C(C#N)C#N

> <pd_targets>
{ALDH1A1,MAPT,TGR,L3MBTL1,EGFR,KDR,TDP1,FFP,RECQL,FGFR1,PDGFRB}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator",Oxidoreductase,Reader,Kinase,Hydrolase,Transferase,"Methyl-lysine/arginine binding protein","Protein Kinase","MBT domain","TK protein kinase gr
oup","Tyrosine protein kinase EGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IV RTKs: VEGF (vascular
 endothelial growth factor) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{Metabolism,"Neuronal System","Gene expression (Transcription)","Signal Transduction","DNA Repair",Disease,"Biological oxidations","Transmission across Chemical Synapses","RNA Polymerase II Transcript
ion","Signaling by GPCR","Signaling by Receptor Tyrosine Kinases","DNA Double-Strand Break Repair","Diseases of signal transduction by growth factor receptors and second messengers","Intracellular sig
naling by second messengers","Phase I - Functionalization of compounds","Neurotransmitter receptors and postsynaptic signal transmission","Generic Transcription Pathway","GPCR downstream signalling","
Signaling by VEGF","Nonhomologous End-Joining (NHEJ)","Signaling by FGFR in disease","PIP3 activates AKT signaling","Ethanol oxidation","Activation of NMDA receptors and postsynaptic events","Transcri
ptional Regulation by TP53","G alpha (q) signalling events","VEGFA-VEGFR2 Pathway","Signaling by FGFR1 in disease","Negative regulation of the PI3K/AKT network","Post NMDA receptor activation events",
"Regulation of TP53 Activity","Gastrin-CREB signalling pathway via PKC and MAPK","VEGFR2 mediated cell proliferation","FGFR1 mutant receptor activation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling
","Activation of AMPK downstream of NMDARs","Regulation of TP53 Activity through Methylation","EGFR Transactivation by Gastrin","Signaling by activated point mutants of FGFR1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"(Z)-Tyrphostin A51","(Z)Tyrphostin A51","2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile","2amino4(3,4,5trihydroxyphenyl)buta1,3diene1,1,3tricarbonitrile",(Z)-AG-183,(Z)AG183,
Q27166454,EI-189,"TYRPHOSTIN 51"}

> <pdid>
PD020213

> <targets>
{EGFRK}

> <classes>
{}

> <pubchem_cids>
{5612}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 14  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.5009    2.2405    0.0000 N   0  0
   -3.8964   -0.7554    0.0000 C   0  0
   -3.8938   -2.2554    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  6  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  3  0
 10 13  1  0
 13 14  3  0
M  END
> <name>
UTKinase_V5

> <id>
28109

> <plate>
Kinase v5-1

> <well>
E07

> <supplier_cmpd_name>
TYRPHOSTIN 1

> <ctcr_id>
4068

> <supplier_cmpd_id>
EI-190

> <smiles>
COc1ccc(cc1)C=C(C#N)C#N

> <pd_targets>
{NFKB1,MAPT,ALDH1A1,BLM,TSHR,NPSR1,CYP3A4,KDM4E,PMP22,APEX1,HPGD,CYP1A2,EGFR}

> <pathway_gtopdb>
{"Other cytosolic protein",Enzyme,"Membrane receptor","Epigenetic regulator","Unclassified protein",Oxidoreductase,"Family A G protein-coupled receptor","Cytochrome P450",Eraser,Kinase,"Peptide recept
or (family A GPCR)","Cytochrome P450 family 3","Lysine demethylase","Cytochrome P450 family 1","Protein Kinase","Glycohormone receptor","Short peptide receptor (family A GPCR)","Cytochrome P450 family
 3A","Jumonji domain-containing","Cytochrome P450 family 1A","TK protein kinase group","Neuropeptide receptor","Cytochrome P450 3A4","Cytochrome P450 1A1","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,Enzymes,"G protein-coupled receptors","Cytochrome P450","Chromatin modifying enzymes","Eicosanoid turnover","Catalytic receptors","Glycoprotein hormone receptors","Neuropeptide S receptor",
"CYP3 family","1.14.11.- Histone demethylases","Prostaglandin synthases","CYP1 family","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth 
factor) receptor family"}

> <pathway_reactome>
{"Immune System","Neuronal System",Metabolism,"DNA Repair",Disease,"Developmental Biology","Signal Transduction","Cytokine Signaling in Immune system","Transmission across Chemical Synapses","Biologic
al oxidations","DNA Double-Strand Break Repair","Infectious disease","Metabolism of lipids","Nervous system development","Base Excision Repair","Signaling by GPCR","Signaling by Interleukins","Neurotr
ansmitter receptors and postsynaptic signal transmission","Phase I - Functionalization of compounds","Homology Directed Repair","Leishmania infection","Biosynthesis of specialized proresolving mediato
rs (SPMs)","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Resolution of Abasic Sites (AP sites)","GPCR downstream signalling","Interleukin-1 family signaling","Activation of NMDA re
ceptors and postsynaptic events","Ethanol oxidation","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Leishmania parasite growth and survival","Biosynthesis of DHA-derive
d SPMs","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","Cytochrome P450 - arranged by substrate type","G alpha (q) signalling events","Interleukin-1 signaling","Post NM
DA receptor activation events","HDR through Homologous Recombination (HRR)","Anti-inflammatory response favouring Leishmania parasite infection","Biosynthesis of maresins","PCNA-Dependent Long Patch B
ase Excision Repair","Biosynthesis of D-series resolvins",Xenobiotics,"Gastrin-CREB signalling pathway via PKC and MAPK","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Activation of AMPK downstream of 
NMDARs","Homologous DNA Pairing and Strand Exchange","ADORA2B mediated anti-inflammatory cytokines production","Biosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylat
ed by CYP1A2","EGFR Transactivation by Gastrin","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Tyrphostin A1","FM 00023",HY-16668,HY16668,"HY 16668",ST019971,UPCMLD0ENAT0503-7296:001,UPCMLD0ENAT05037296:001,"UPCMLD0ENAT0503 7296:001",AB0118789,DB-047364,DB047364,"DB 047364","Benzene, 1-methox
y-4-(2,2-dicyanoethenyl)","Benzene, 1methoxy4(2,2dicyanoethenyl)",Benzene,1methoxy,"EMD 658390",EI-190,658390,"TYRPHOSTIN 1"}

> <pdid>
PD015003

> <targets>
{"Negative control for tyrosine kinase inhibitors.","Interleukin Related"}

> <classes>
{Immunology/Inflammation}

> <pubchem_cids>
{2063}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 17  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -1.3101    6.7502    0.0000 N   0  0
   -2.6024    2.9967    0.0000 C   0  0
   -3.9001    2.2444    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.6003   -1.4978    0.0000 N   0  3
   -2.6029   -2.9978    0.0000 O   0  5
   -3.8983   -0.7459    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  3  0
  6  9  1  0
  9 10  3  0
  4 11  2  0
 11 12  1  0
 12 13  2  0
 13  2  1  0
 13 14  1  0
 12 15  1  0
 15 16  1  0
 15 17  2  0
M  CHG  2  15   1  16  -1
M  END
> <name>
UTKinase_V5

> <id>
28110

> <plate>
Kinase v5-1

> <well>
E09

> <supplier_cmpd_name>
TYRPHOSTIN AG 1288

> <ctcr_id>
3209

> <supplier_cmpd_id>
EI-335

> <smiles>
Oc1cc(C=C(C#N)C#N)cc(c1O)[N+]([O-])=O

> <pd_targets>
{RORC,ALDH1A1,HPGD,RECQL,MAPT,COMT,FTL,KMT2A,MEN1}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Other cytosolic protein","Unclassified protein","Epigenetic regulator","Nuclear receptor",Oxidoreductase,Transferase,Reader,"Nuclear hormone receptor subfamily 1",Bromo
domain,"Nuclear hormone receptor subfamily 1 group F","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Eicosanoid turnover","Catecholamine turnover","1F. Retinoic acid-related orphans","Prostaglandin synthases"}

> <pathway_reactome>
{"Gene expression (Transcription)",Metabolism,"Neuronal System","Vesicle-mediated transport","RNA Polymerase II Transcription","Biological oxidations","Metabolism of lipids","Transmission across Chemi
cal Synapses","Membrane Trafficking","Generic Transcription Pathway","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotransmitter receptors 
and postsynaptic signal transmission","Neurotransmitter clearance","trans-Golgi Network Vesicle Budding","Transcriptional regulation by RUNX3","Ethanol oxidation","Biosynthesis of DHA-derived SPMs","A
ctivation of NMDA receptors and postsynaptic events","Dopamine clearance from the synaptic cleft","Golgi Associated Vesicle Biogenesis","RUNX3 Regulates Immune Response and Cell Migration","Biosynthes
is of D-series resolvins","Post NMDA receptor activation events","Enzymatic degradation of dopamine by COMT","Activation of AMPK downstream of NMDARs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{116313-73-6,116313736,AG-1288,AG1288,"TYRPHOSTIN AG 1288","AG 1288","2-((3,4-dihydroxy-5-nitrophenyl)methylidene)propanedinitrile","2((3,4dihydroxy5nitrophenyl)methylidene)propanedinitrile",CHEMBL166
486,"Propanedinitrile, 2-((3,4-dihydroxy-5-nitrophenyl)methylene)-","Propanedinitrile, 2((3,4dihydroxy5nitrophenyl)methylene)",2-(3,2(3,4-dihydroxy-5-nitrobenzylidene)malono,4dihydroxy5nitrobenzyliden
e)malono,EI-335}

> <pdid>
PD118250

> <targets>
{"Tyrosine kinases"}

> <classes>
{}

> <pubchem_cids>
{3856780}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Cl  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17 11  1  0
  9 18  2  0
 18  5  1  0
 18 19  1  0
 19 20  2  0
 20  3  1  0
 20 21  1  0
 21 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28111

> <plate>
Kinase v5-1

> <well>
E11

> <supplier_cmpd_name>
TYRPHOSTIN AG 1478

> <ctcr_id>
2375

> <supplier_cmpd_id>
EI-277

> <smiles>
COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC

> <pd_targets>
{ABL1,ABL2,MAPT,EGFR,MAPK1,KDM4E,ALOX15,LEF,BLM,HPGD,NFKB1,HSD17B10,PMP22,CYP3A4,GMNN,FBP1,PKMYT1,LMNA,RAF1,HIF1A,CYP2D6,CYP1A2,MAPK14,CHRM1,FFP,GLA,TP53,KMT2A,MEN1,ALDH1A1,MKNK1,SRC,LCK,KDR,EPHB2,TSH
R,ERBB2,CYP2C19,MAPK11,MAPK12,MAPK13,ALD,RORC,CDK1,ABL,ERBB4,CYP2C9,PDGFRB,ABCG2,GAK}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator","Unclassified protein","Other nuclear protein","Transcription factor","Membrane receptor",Kinase,Eraser,Oxidoreductase,Protease,"Cytochrome P45
0","Family A G protein-coupled receptor",Transferase,Hydrolase,Reader,"Protein Kinase","Lysine demethylase","Metallo protease","Cytochrome P450 family 3","Cytochrome P450 family 2","Cytochrome P450 fa
mily 1","Small molecule receptor (family A GPCR)",Bromodomain,"TK protein kinase group","CMGC protein kinase group","Jumonji domain-containing","Metallo protease MAE clan","Cytochrome P450 family 3A",
"Other protein kinase group","TKL protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Monoamine receptor","CAMK protein kinase group","Tyrosine protein kinase Abl family","T
yrosine protein kinase EGFR family","CMGC protein kinase MAPK family","Metallo protease M34 family","Cytochrome P450 3A4","Other protein kinase WEE family","TKL protein kinase RAF family","Cytochrome 
P450 2D6","Cytochrome P450 1A1","Acetylcholine receptor","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Src family","CMGC protein kinase ERK1","CMGC protein kinase p38 subfamily","CAMK 
protein kinase MNK subfamily",Transporter,"Nuclear receptor","Primary active transporter","Peptide receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","ATP-binding cassette","Glycohormone
 receptor","Cytochrome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","ABCG subfamily","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Eph family","Cytochrome P450 2C19
","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase CDK family","Cytochrome P450 2C9","Tyrosine protein kinase PDGFR family","Other protein kinase NAK family","CMGC protein 
kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","G protein-coupled receptors","Receptor kinases","CMGC: Containing
 CDK",MAPK,GSK3,"CLK families","1.14.11.- Histone demethylases",Lipoxygenases,"Prostaglandin synthases","CYP3 family","CYP2 family: drug metabolising subset","CYP1 family","Acetylcholine receptors (mu
scarinic)","CAMK: Calcium/calmodulin-dependent protein kinases","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Other protein kinases","TKL: Tyrosine kinase-like","MAPK-Activa
ted Protein Kinase (MAPKAPK) family","Receptor tyrosine kinases (RTKs)","ERK subfamily","WEE family","RAF family","p38 subfamily","MKN subfamily","Non-receptor tyrosine kinases (nRTKs)","Type I RTKs: 
ErbB (epidermal growth factor) receptor family","Src family",Transporters,"Nuclear hormone receptors","ATP-binding cassette transporter family","Glycoprotein hormone receptors","1F. Retinoic acid-rela
ted orphans","ABCG subfamily","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","Numb-associated kinase (NAK) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","T
ype XIII RTKs: Ephrin receptor family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Neuronal System","Signal Transduction","Immune System",Metabolism,Disease,"DNA Repair","Developmental Biology","Cell Cycle","Cellular responses to external stimuli","Transmission across Chemical Syn
apses","Signaling by GPCR","Innate Immune System","Metabolism of lipids","Infectious disease","DNA Double-Strand Break Repair","Cytokine Signaling in Immune system","Metabolism of amino acids and deri
vatives","Nervous system development",Mitotic,"Metabolism of carbohydrates","MAPK family signaling cascades","Cellular responses to stress","Biological oxidations","Cell Cycle Checkpoints","Signaling 
by Receptor Tyrosine Kinases","Neurotransmitter receptors and postsynaptic signal transmission","GPCR downstream signalling","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving med
iators (SPMs)","Uptake and actions of bacterial toxins","Homology Directed Repair","Signaling by Interleukins","Branched-chain amino acid catabolism","EGR2 and SOX10-mediated initiation of Schwann cel
l myelination","Mitotic G1 phase and G1/S transition","Glucose metabolism","Mitotic G2-G2/M phases","M Phase","MAPK1/MAPK3 signaling","Cellular response to hypoxia","Phase I - Functionalization of com
pounds","GPCR ligand binding","Sphingolipid metabolism","G1/S DNA Damage Checkpoints","Signaling by FGFR","Signaling by NTRKs","HIV Infection","Activation of NMDA receptors and postsynaptic events","G
 alpha (q) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Biosynthesis of DPA-derived SPMs","Uptake and function of anthrax toxins","HDR through Homologous Recombination (HRR) or Single Str
and Annealing (SSA)","Biosynthesis of DHA-derived SPMs","Interleukin-1 family signaling","G1/S Transition",Gluconeogenesis,"G2/M Transition","Mitotic Metaphase and Anaphase","RAF/MAP kinase cascade","
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Cytochrome P450 - arranged by substrate type","Class A/1 (Rhodopsin-like receptors)","Glycosphingolipid metabolism","p53-Depe
ndent G1/S DNA damage checkpoint","Ethanol oxidation","Signaling by FGFR4","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Post NMDA receptor activation events","Gastrin-CREB signallin
g pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Biosynthesis of DPAn-3 SPMs","HDR through Homologous Recombination (HRR)","Biosynthesis of D-series resolvins","Interleukin-1 
signaling","Biosynthesis of maresins","Activation of the pre-replicative complex","Cyclin A/B1/B2 associated events during G2/M transition","Mitotic Anaphase","Negative regulation of MAPK pathway",Xen
obiotics,"Amine ligand-binding receptors","p53-Dependent G1 DNA Damage Response","Negative regulation of FGFR4 signaling","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathoge
nesis","Activation of AMPK downstream of NMDARs","EGFR Transactivation by Gastrin","MAP kinase activation","Biosynthesis of DPAn-3-derived protectins and resolvins","Homologous DNA Pairing and Strand 
Exchange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of maresin-like SPMs","Nuclear Envelope (NE) Reassembly","Negative feedback regulation of MAPK pathway","CYP2E1 reactions","Aromati
c amines can be N-hydroxylated or N-dealkylated by CYP1A2","Muscarinic acetylcholine receptors","Stabilization of p53","Spry regulation of FGF signaling","Signalling to RAS","Nef-mediates down modulat
ion of cell surface receptors by recruiting them to clathrin adapters","MAPK targets/ Nuclear events mediated by MAP kinases","Presynaptic phase of homologous DNA pairing and strand exchange","Initiat
ion of Nuclear Envelope (NE) Reformation","Autodegradation of the E3 ubiquitin ligase COP1","p38MAPK events","Nef Mediated CD4 Down-regulation","ERK/MAPK targets","Activation of the AP-1 family of tra
nscription factors","ERKs are inactivated","Gene expression (Transcription)","Vesicle-mediated transport","RNA Polymerase II Transcription","Intracellular signaling by second messengers","Abacavir tra
nsport and metabolism","Membrane Trafficking","Signaling by VEGF","Axon guidance","Leishmania infection","Generic Transcription Pathway","Regulation of mitotic cell cycle","PIP3 activates AKT signalin
g","Abacavir transmembrane transport","trans-Golgi Network Vesicle Budding","VEGFA-VEGFR2 Pathway","EPH-Ephrin signaling","Leishmania parasite growth and survival","Semaphorin interactions","Transcrip
tional regulation by RUNX3","APC/C-mediated degradation of cell cycle proteins","Parasite infection","Negative regulation of the PI3K/AKT network","Golgi Associated Vesicle Biogenesis","VEGFR2 mediate
d cell proliferation","EPHB-mediated forward signaling","Anti-inflammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","RUNX3 Regulates Immune Response and Cell 
Migration","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Leishmania phagocytosis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","ADORA2B mediated anti-inflammatory
 cytokines production","Sema4D induced cell migration and growth-cone collapse","APC/C:Cdc20 mediated degradation of mitotic proteins","Long-term potentiation","FCGR3A-mediated phagocytosis","APC:Cdc2
0 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{EGFR,MAPK14}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{AG-1478,AG1478,"AG 1478",153436-53-4,153436534,"153436 53 4","Tyrphostin AG 1478","N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine","N(3chlorophenyl)6,7dimethoxyquinazolin4amine","N (3 chloropheny
l) 6,7 dimethoxyquinazolin 4 amine","EMD 658552",EI-277,658552,"TYRPHOSTIN AG 1478"}

> <pdid>
PD002607

> <targets>
{EGFR,PTK,EGFRK}

> <classes>
{}

> <pubchem_cids>
{2051}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 20  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -3.8978    3.7504    0.0000 C   0  0
   -3.9003    5.2504    0.0000 C   0  0
   -5.2005    5.9983    0.0000 C   0  0
   -6.4984    5.2463    0.0000 C   0  0
   -6.4960    3.7463    0.0000 C   0  0
   -5.1957    2.9983    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  2  0
 11  2  1  0
 11 12  1  0
  7 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28112

> <plate>
Kinase v5-1

> <well>
E13

> <supplier_cmpd_name>
TYRPHOSTIN AG 1295

> <ctcr_id>
4650

> <supplier_cmpd_id>
AC-1133

> <smiles>
Cc1cc2ncc(nc2cc1C)c3ccccc3

> <pd_targets>
{NR1H2,PDGFRA,PDGFRB,SMN1,RAB9A,RORC,NPC1,KDR,FLT3}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator",Transporter,"Nuclear receptor",Kinase,Reader,Hydrolase,"Nuclear hormone receptor subfamily 1","Protein Kinase","Methyl-lysine/arginine binding pro
tein","Nuclear hormone receptor subfamily 1 group H","TK protein kinase group","Tudor domain","Nuclear hormone receptor subfamily 1 group F","Nuclear hormone receptor subfamily 1 group H member 3","Ty
rosine protein kinase PDGFR family","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase VEGFR family"}

> <pathway_chembl>
{Receptors,Transporters,"Nuclear hormone receptors","Catalytic receptors","SLC superfamily of solute carriers","1H. Liver X receptor-like receptors","Receptor kinases","1F. Retinoic acid-related orpha
ns","SLC65 NPC-type cholesterol transporters","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial 
growth factor) receptor family"}

> <pathway_reactome>
{"Metabolism of proteins","Metabolism of RNA","Signal Transduction","Gene expression (Transcription)","Transport of small molecules","Post-translational protein modification","Metabolism of non-coding
 RNA","Intracellular signaling by second messengers","Signaling by Rho GTPases","RNA Polymerase II Transcription","Plasma lipoprotein assembly",remodeling,"and clearance","Signaling by Receptor Tyrosi
ne Kinases",SUMOylation,"snRNP Assembly","PIP3 activates AKT signaling","Rho GTPase cycle","Generic Transcription Pathway","Plasma lipoprotein clearance","Signaling by VEGF","Signaling by Insulin rece
ptor","SUMO E3 ligases SUMOylate target proteins","Negative regulation of the PI3K/AKT network","RHOBTB GTPase Cycle","Transcriptional regulation by RUNX3","LDL clearance","VEGFA-VEGFR2 Pathway","Insu
lin receptor signalling cascade","SUMOylation of intracellular receptors",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","RHOBTB3 ATPase cycle","RUNX3 Regulates Immune Response and Cell Migration","
VEGFR2 mediated cell proliferation","IRS-mediated signalling","PI3K Cascade"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"6,7-Dimethyl-2-phenylquinoxaline","6,7Dimethyl2phenylquinoxaline","6,7 Dimethyl 2 phenylquinoxaline",71897-07-9,71897079,"71897 07 9",ag1295,"AG 1295",AG-1295,AG1295,"6,7-Dimethyl-2-phenyl-quinoxali
ne",6,"7 Dimethyl 2 phenyl quinoxal","EMD 658550",AC-1133,658550,"TYRPHOSTIN AG 1295"}

> <pdid>
PD019059

> <targets>
{"Tyrosine kinases"}

> <classes>
{}

> <pubchem_cids>
{2048}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 21  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 C   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 C   0  0
    3.8975   -2.2510    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -1.3101    6.7502    0.0000 N   0  0
   -2.6024    2.9967    0.0000 C   0  0
   -3.9001    2.2444    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.5988   -1.5004    0.0000 C   0  0
   -3.8983   -0.7513    0.0000 C   0  0
   -2.5983   -3.0004    0.0000 C   0  0
   -3.8975   -2.2510    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  3  0
  9 12  1  0
 12 13  3  0
  7 14  2  0
 14 15  1  0
 15 16  2  0
 16  5  1  0
 16 17  1  0
 15 18  1  0
 18 19  1  0
 18 20  1  0
 18 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28113

> <plate>
Kinase v5-1

> <well>
E15

> <supplier_cmpd_name>
TYRPHOSTIN 9

> <ctcr_id>
3295

> <supplier_cmpd_id>
EI-215

> <smiles>
CC(C)(C)c1cc(C=C(C#N)C#N)cc(c1O)C(C)(C)C

> <pd_targets>
{CYP1A2,LMNA,MAPT,HIF1A,PMP22,LEF,THPO,CYP3A4,GMNN,CYP2C19,ALOX15,HPGD,KMT2A,MEN1,HSD17B10,CYP2C9,FTL,ALDH1A1,FFP,CHRM1,NFKB1,TGR,BLM,TP53,NPSR1,TSHR,AMPC,RECQL,MTOR}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein","Other cytosolic protein","Transcription factor","Unclassified protein","Epigenetic regulator","Membrane receptor","Cytochrome P450",Protease,Oxidoreductase,Reader,Tran
sferase,"Family A G protein-coupled receptor",Hydrolase,Kinase,"Cytochrome P450 family 1","Metallo protease","Cytochrome P450 family 3","Cytochrome P450 family 2",Bromodomain,"Small molecule receptor 
(family A GPCR)","Peptide receptor (family A GPCR)","Protein Kinase","Cytochrome P450 family 1A","Metallo protease MAE clan","Cytochrome P450 family 3A","Cytochrome P450 family 2C","Monoamine receptor
","Short peptide receptor (family A GPCR)","Glycohormone receptor","Atypical protein kinase group","Cytochrome P450 1A1","Metallo protease M34 family","Cytochrome P450 3A4","Cytochrome P450 2C19","Cyt
ochrome P450 2C9","Acetylcholine receptor","Neuropeptide receptor","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Eicosanoid turnover","G protein-coupled receptors","Kinases (EC 2.7.x.x)","CYP1 family","CYP3 family","CYP2 family: drug metabolising subset",Lipoxygenases,"Prost
aglandin synthases","Acetylcholine receptors (muscarinic)","Neuropeptide S receptor","Glycoprotein hormone receptors",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP sub
family"}

> <pathway_reactome>
{Metabolism,"Cell Cycle","Neuronal System","Cellular responses to external stimuli","Developmental Biology",Disease,Hemostasis,"Vesicle-mediated transport","Signal Transduction","Immune System","DNA R
epair","Gene expression (Transcription)","Biological oxidations",Mitotic,"Transmission across Chemical Synapses","Cellular responses to stress","Nervous system development","Infectious disease","Plate
let activation","signaling and aggregation","Metabolism of lipids","Metabolism of amino acids and derivatives","Membrane Trafficking","Signaling by GPCR","Cytokine Signaling in Immune system","DNA Dou
ble-Strand Break Repair","Cell Cycle Checkpoints","RNA Polymerase II Transcription","Phase I - Functionalization of compounds","M Phase","Neurotransmitter receptors and postsynaptic signal transmissio
n","Cellular response to hypoxia","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Uptake and actions of bacterial toxins","Platelet Aggregation (Plug Formation)","Biosynthesis of spe
cialized proresolving mediators (SPMs)","Mitotic G1 phase and G1/S transition","Branched-chain amino acid catabolism","trans-Golgi Network Vesicle Budding","GPCR ligand binding","Signaling by Interleu
kins","Homology Directed Repair","G1/S DNA Damage Checkpoints","Leishmania infection","Generic Transcription Pathway","Cytochrome P450 - arranged by substrate type","Mitotic Metaphase and Anaphase","A
ctivation of NMDA receptors and postsynaptic events","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Uptake and function of anthrax toxins","Biosynthesis of DHA-derived SPM
s","G1/S Transition","Biosynthesis of DPA-derived SPMs","Golgi Associated Vesicle Biogenesis","Ethanol oxidation","Class A/1 (Rhodopsin-like receptors)","Interleukin-1 family signaling","HDR through H
omologous Recombination (HRR) or Single Strand Annealing (SSA)","p53-Dependent G1/S DNA damage checkpoint","Leishmania parasite growth and survival","Transcriptional Regulation by TP53",Xenobiotics,"M
itotic Anaphase","Post NMDA receptor activation events","Biosynthesis of maresins","Activation of the pre-replicative complex","Biosynthesis of DPAn-3 SPMs","Biosynthesis of D-series resolvins","Amine
 ligand-binding receptors","Interleukin-1 signaling","HDR through Homologous Recombination (HRR)","p53-Dependent G1 DNA Damage Response","Anti-inflammatory response favouring Leishmania parasite infec
tion","Regulation of TP53 Activity","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Nuclear Envelope (NE) Reassembly","Activation of AMPK downstream of NMDARs","Biosynthesis of mar
esin-like SPMs","CYP2E1 reactions","Biosynthesis of DPAn-3-derived protectins and resolvins","Muscarinic acetylcholine receptors","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Homologous DNA Pairing a
nd Strand Exchange","Stabilization of p53","ADORA2B mediated anti-inflammatory cytokines production","Regulation of TP53 Expression and Degradation","Initiation of Nuclear Envelope (NE) Reformation","
Presynaptic phase of homologous DNA pairing and strand exchange","Autodegradation of the E3 ubiquitin ligase COP1","Regulation of TP53 Degradation"}

> <broad_targets>
{}

> <broad_moa>
{"protein tyrosine kinase inhibitor","tyrosine kinase inhibitor"}

> <synonyms>
{Malonoben,"tyrphostin A9",10537-47-0,10537470,"Tyrphostin 9","2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile","2(3,5Ditertbutyl4hydroxybenzylidene)malononitrile","NSC 242557","GCP 5126","ENT
 27910","SF 6847","AG 17",UNII-87TE8MRS65,UNII87TE8MRS65,"(3,5-Di-t-butyl-4-hydroxybenzylidene)malononitrile","(3,5Ditbutyl4hydroxybenzylidene)malononitrile",S-15126,S15126,T2479,NSC242557,EI-215,"TYR
PHOSTIN 9"}

> <pdid>
PD002632

> <targets>
{PDGFRK}

> <classes>
{}

> <pubchem_cids>
{5614}

$$$$
UTKinase_V5
  SciTegic11012413002D

 16 17  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.5951   -3.0039    0.0000 P   0  0
    2.5923   -4.5039    0.0000 O   0  0
    1.2948   -3.7516    0.0000 O   0  0
    3.8926   -3.7566    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  6  1  0
 11 12  2  0
 12  3  1  0
  2 13  1  0
 13 14  1  0
 13 15  1  0
 13 16  2  0
M  END
> <name>
UTKinase_V5

> <id>
28114

> <plate>
Kinase v5-1

> <well>
E17

> <supplier_cmpd_name>
Hydroxy-2-naphthalenylmethylphosphonic acid

> <ctcr_id>
6866

> <supplier_cmpd_id>
EI-247

> <smiles>
OC(c1ccc2ccccc2c1)[P](O)(O)=O

> <pd_targets>
{MAPT,INSR}

> <pathway_gtopdb>
{"Other cytosolic protein",Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase InsR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Neuronal System","Signal Transduction","Transmission across Chemical Synapses","Intracellular signaling by second messengers","Neurotransmitter receptors and postsynaptic signal transmission","PIP3 
activates AKT signaling","Activation of NMDA receptors and postsynaptic events","Negative regulation of the PI3K/AKT network","Post NMDA receptor activation events",PI5P,"PP2A and IER3 Regulate PI3K/A
KT Signaling","Activation of AMPK downstream of NMDARs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{CG10062,CCG-100625,CCG100625,HNMPA,"(Hydroxy-2-naphthalenylmethyl)phosphonic acid","(Hydroxy2naphthalenylmethyl)phosphonic acid","(hydroxy(naphthalen-2-yl)methyl)phosphonic acid","(hydroxy(naphthalen
2yl)methyl)phosphonic acid",132541-52-7,132541527,120943-99-9,120943999,"Hydroxy(2-naphthyl)methanephosphonic Acid","Hydroxy(2naphthyl)methanephosphonic Acid","Phosphonic acid, P-(hydroxy-2-naphthalen
ylmethyl)-","Phosphonic acid, P(hydroxy2naphthalenylmethyl)",OH-Name-,OHName,EI-247,"Hydroxy-2-naphthalenylmethylphosphonic acid"}

> <pdid>
PD017948

> <targets>
{IRK}

> <classes>
{}

> <pubchem_cids>
{129317}

$$$$
UTKinase_V5
  SciTegic11012413002D

 43 51  0  0  1  0            999 V2000
   -4.6251    3.1704    0.0000 C   0  0
   -4.1487    2.2911    0.0000 O   0  0
   -2.6500    2.2500    0.0000 C   0  0  2  0  0  0
   -1.8100    3.5000    0.0000 C   0  0  1  0  0  0
   -0.2400    3.5200    0.0000 C   0  0
    0.5000    2.1800    0.0000 C   0  0  1  0  0  0
   -1.0600    2.1800    0.0000 O   0  0
   -1.8300    0.9300    0.0000 C   0  0  1  0  0  0
   -3.1401    0.1996    0.0000 C   0  0
   -0.9800   -0.7800    0.0000 N   0  0
   -2.1300   -1.4600    0.0000 C   0  0
   -3.3200   -0.7600    0.0000 C   0  0
   -4.5500   -1.4800    0.0000 C   0  0
   -4.5800   -2.7700    0.0000 C   0  0
   -3.3400   -3.4700    0.0000 C   0  0
   -2.1300   -2.7900    0.0000 C   0  0
    0.2400   -2.7700    0.0000 C   0  0
    1.4300   -3.4700    0.0000 C   0  0
    1.7600   -4.9700    0.0000 C   0  0
    3.2600   -5.0800    0.0000 N   0  0
    3.8500   -3.6300    0.0000 C   0  0
    5.2941   -3.2244    0.0000 O   0  0
    2.6600   -2.7500    0.0000 C   0  0
    2.6800   -1.4600    0.0000 C   0  0
    3.7900    0.5600    0.0000 C   0  0
    4.9600    1.2800    0.0000 C   0  0
    4.9600    2.6300    0.0000 C   0  0
    3.8100    3.2900    0.0000 C   0  0
    2.6400    2.5900    0.0000 C   0  0
    2.6400    1.2400    0.0000 C   0  0
    1.4900    0.5400    0.0000 N   0  0
    1.4500   -0.7600    0.0000 C   0  0
    0.2400   -1.4400    0.0000 C   0  0
   -2.5435    4.8102    0.0000 N   0  0
   -1.7763    6.0991    0.0000 C   0  0
   -4.0442    4.8306    0.0000 C   0  0
   -4.5556    3.9713    0.0000 O   0  0
   -4.7776    6.1400    0.0000 C   0  0
   -6.2775    6.1627    0.0000 C   0  0
   -7.0079    7.4728    0.0000 C   0  0
   -6.2384    8.7604    0.0000 C   0  0
   -4.7386    8.7379    0.0000 C   0  0
   -4.0082    7.4277    0.0000 C   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  4  5  1  0
  6  5  1  6
  6  7  1  0
  7  8  1  0
  8  3  1  0
  8  9  1  1
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 18  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 30 31  1  0
 31  6  1  0
 31 32  1  0
 32 24  1  0
 32 33  2  0
 33 10  1  0
 33 17  1  0
  4 34  1  6
 34 35  1  0
 34 36  1  0
 36 37  2  0
 36 38  1  0
 38 39  2  0
 39 40  1  0
 40 41  2  0
 41 42  1  0
 42 43  2  0
 43 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28115

> <plate>
Kinase v5-1

> <well>
E19

> <supplier_cmpd_name>
PKC-412

> <ctcr_id>
6387

> <supplier_cmpd_id>
EI-370

> <smiles>
CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35)N(C)C(=O)c9ccccc9

> <pd_targets>
{FLT3,DYRK1A,PDPK1,MAPK9,PHKG1,PIP5K1A,TYRO3,WEE1,STK25,ZAP70,PRKACB,PTK2B,CSK,TEK,NTRK2,NTRK3,EGFR,NUAK1,AURKA,PDGFRB,PIM2,AXL,MARK2,MARK4,MET,CAMK2B,CAMKK2,STK16,HIPK3,PRKCD,PRKCE,PRKD2,PRKD3,RET,FG
FR1,FGFR2,JAK3,MAPK10,KIT,SRPK2,TSSK1B,FYN,GAK,ALK,DDR1,AKT2,LCK,LTK,LYN,LRRK2,TIE1,TNK2,NTRK1,PDGFRA,PIM1,PIM3,CAMK1D,CAMK1G,CAMKK1,PKN1,PLK4,PRKG2,EIF2AK2,GSK3B,MAPK8,MAP2K3,EIF2AK4,HCK,MAP3K9,CSF1R
,PAK1,PAK2,FRK,SRC,RPS6KA1,RPS6KA3,RPS6KA4,RPS6KA5,MAP4K2,MINK1,PRPF4B,RIOK2,DAPK3,GSK3A,IKBKE,MARK3,AAK1,ABL1,STK4,MAP3K11,ROCK1,ULK3,STK3,CHEK1,CLK2,CLK4,SLK,SIK1,FLT1,ROS1,ERN1,GRK1,GRK4,HIPK4,MAP3
K13,MAP3K3,SIK2,PRKAA1,DMPK,LATS2,STK10,RPS6KB1,JAK1,RIOK3,SRPK1,TNK1,PRKAA2,AKT1,AKT3,LATS1,STK17A,SGK3,FLT4,PAK3,PRKX,CLK1,CLK3,PHKG2,BRSK1,MAP4K4,MAP4K5,MAP2K6,MERTK,CAMK2G,PKN2,PRKCQ,FER,PRKG1,RPS
6KA6,YES1,PIP4K2B,PIK3CA,MAP4K1,MAP4K3,AURKB,BMP2K,BLK,MAP2K4,CSNK2A1,STK17B,TYK2,STK11,IRAK3,CDK19,AURKC,CILK1,EPHB6,CHUK,ROCK2,SRPK3,TBK1,TNKS2,TTK,MELK,CAMK1,NUAK2,FGFR3,RPS6KA2,PIK3C2G,PRKCA,MAP3K
7,STK32A,MYLK4,TNIK,PRKACA,MARK1,JAK2,RIOK1,DYRK1B,MYLK,FGR,HIPK2,HUNK,KDR,CAMK2A,SYK,PRKCH,STK33,MYLK3,DAPK2,MKNK2,BRSK2,MAST1,GRK7,MAP3K2,SIK3,MAP3K19,CAMK2D,TUBA1A,MAP3K10,ERBB4,PIK3C2B,DSTYK,CDPK1
,DAPK1,IKBKB,PRKCB,PRKCG,PRKCI,PRKCZ,PRKD1,PRKACG}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Structural protein",Kinase,Transferase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","AGC protein kinase group","CAMK protein kinase group","Ot
her protein kinase group","STE protein kinase group","TKL protein kinase group","Atypical protein kinase group","Tyrosine protein kinase PDGFR family","CMGC protein kinase DYRK family","AGC protein ki
nase PDK1 subfamily","CMGC protein kinase MAPK family","CAMK protein kinase PHk family","Tyrosine protein kinase Axl family","Other protein kinase WEE family","STE protein kinase STE20 family","Tyrosi
ne protein kinase Syk family","AGC protein kinase PKA family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Csk family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Tr
k family","Tyrosine protein kinase EGFR family","CAMK protein kinase CAMK1 family","Other protein kinase AUR family","CAMK protein kinase PIM family","Tyrosine protein kinase Met family","CAMK protein
 kinase CAMK2 family","Other protein kinase CAMKK family","Other protein kinase NAK family","AGC protein kinase PKC family","CAMK protein kinase PKD family","Tyrosine protein kinase Ret family","Tyros
ine protein kinase FGFR family","Tyrosine protein kinase JakA family","CMGC protein kinase SRPK family","CAMK protein kinase TSSK family","Tyrosine protein kinase Src family","TKL protein kinase STKR 
family","Tyrosine protein kinase DDR family","AGC protein kinase AKT family","Tyrosine protein kinase Alk family","TKL protein kinase LRRK family","Tyrosine protein kinase Ack family","AGC protein kin
ase PKN family","Other protein kinase PLK family","AGC protein kinase PKG family","Other protein kinase PEK family","CMGC protein kinase GSK family","STE protein kinase STE7 family","TKL protein kinas
e MLK family","AGC protein kinase RSK family","Atypical protein kinase RIO family","CAMK protein kinase DAPK family","Tyrosine protein kinase Abl family","AGC protein kinase DMPK family","Other protei
n kinase ULK family","CMGC protein kinase CLK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Sev family","AGC protein kinase GRK family","STE protein kinase STE11 family","AGC
 protein kinase NDR family","AGC protein kinase SGK family","Tyrosine protein kinase Fer family","Other protein kinase CK2 family","TKL protein kinase IRAK family","CMGC protein kinase CDK family","CM
GC protein kinase RCK family","Other protein kinase IKK family","Other protein kinase TTK family","AGC protein kinase YANK family","CAMK protein kinase MLCK family","CAMK protein kinase unique family"
,"CAMK protein kinase MAPKAPK family","AGC protein kinase MAST family","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase JNK subfamily","STE protein kinase YSK subfamily","CAMK protein kinase
 NuaK subfamily","CAMK protein kinase MARK subfamily","Other protein kinase Meta subfamily","CMGC protein kinase HIPK subfamily","AGC protein kinase PKC delta subfamily","AGC protein kinase PKC eta su
bfamily","Tyrosine protein kinase SrcA","TKL protein kinase STKR Type 1 subfamily","Other protein kinase PKR","Other protein kinase GCN2 subfamily","TKL protein kinase MLK subfamily","STE protein kina
se PAKA subfamily","AGC protein kinase RSK subfamily","AGC protein kinase MSK subfamily","STE protein kinase KHS subfamily","STE protein kinase MSN subfamily","Atypical protein kinase RIO2 subfamily",
"STE protein kinase MST subfamily","AGC protein kinase ROCK subfamily","CAMK protein kinase CHK1 subfamily","STE protein kinase SLK subfamily","CAMK protein kinase QIK subfamily","AGC protein kinase G
RK subfamily","TKL protein kinase LZK subfamily","STE protein kinase MEKK2","CAMK protein kinase AMPK subfamily","AGC protein kinase GEK subfamily","AGC protein kinase p70 subfamily","Atypical protein
 kinase RIO3 subfamily","CAMK protein kinase BRSK subfamily","CAMK protein kinase LKB subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase MAK","CAMK protein kinase MELK subfamily","AG
C protein kinase PKC alpha subfamily","TKL protein kinase TAK1 subfamily","Atypical protein kinase RIO1 subfamily","CAMK protein kinase MNK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Poly ADP-ribose polymerases",Tubulins,"Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: 
Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","Lipid modifying kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Atypical,"TK: Tyr
osine kinase","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","PDK1 family","Mitogen-activated protein kinases (MAP kinases)","Phosphorylase kinase (PHK) family","Type I
 PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","Other protein kinases","STE20 family","Protein kinase A (PKA) family","CAMK-like (CAMKL) family","PIM family","CAMK2 family","Protei
n kinase C (PKC) family","Protein kinase D (PKD) family","SRPK family","Testis specific kinase (TSSK) family","Akt (Protein kinase B","PKB) family","TKL: Tyrosine kinase-like","CAMK1 family","Protein 
kinase N (PKN) family","Protein kinase G (PKG) family","Glycogen synthase kinase (GSK) family","STE7 family","RSK family","RIO family","Death-associated kinase (DAPK) family","DMPK family","CLK family
","G protein-coupled receptor kinases (GRKs)","STE11 family","NDR family","SGK family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)",Phosphatidylinositol-4,"5-bisphosphate
 3-kinase family","Cyclin-dependent kinase (CDK) family","RCK family","Phosphatidylinositol-4-phosphate 3-kinase family","YANK family","Myosin Light Chain Kinase (MLCK) family","CAMK-unique family","M
APK-Activated Protein Kinase (MAPKAPK) family","MAST family","Receptor tyrosine kinases (RTKs)","Dyrk1 subfamily","JNK subfamily","WEE family","YSK subfamily","Non-receptor tyrosine kinases (nRTKs)","
NuaK subfamily","Aurora kinase (Aur) family","MARK subfamily","CAMKK family","NAK family","HIPK subfamily","Delta subfamily","Eta subfamily","Numb-associated kinase (NAK) family","Leucine-rich repeat 
kinase (LRRK) family","Polo-like kinase (PLK) family","PEK family","GSK subfamily","Mixed Lineage Kinase (MLK) family","PAKA subfamily","RSK subfamily","MSK subfamily","KHS subfamily","MSN subfamily",
"PRP4 subfamily","RIO2 subfamily","IKK family","MST subfamily","Rho kinase","Unc-51-like kinase (ULK) family","CHK1 subfamily","SLK subfamily","QIK subfamily","IRE family","Opsin/rhodopsin kinases","G
RK4 subfamily","AMPK subfamily","GEK subfamily","p70 subfamily","RIO3 subfamily","BRSK subfamily","Casein kinase 2 (CK2) family","LKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family
","CDK8 subfamily","TTK family","MELK subfamily","RIO1 subfamily","HUNK subfamily","MKN subfamily","STE20 subfamily","Other-unique family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type 
XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Syk family","Fak family","Csk family","Type XII RTKs: TIE family of angiopoietin receptors","Type VII RTKs: Neurotrophin receptor/Trk family",
"Type I RTKs: ErbB (epidermal growth factor) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Meta subfamily","Type XIV RTKs: RET","Type V RTKs: FGF (fibroblast growth f
actor) receptor family","Janus kinase (JakA) family","Src family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Ack family","Other P
EK family kinases","GCN2 subfamily","MLK subfamily","Abl family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XVII RTKs: ROS receptors","LZK subfamily","Fer family",
"Type XIII RTKs: Ephrin receptor family","TAK1 subfamily"}

> <pathway_reactome>
{"Signal Transduction","Cell Cycle","Gene expression (Transcription)","Immune System",Metabolism,Disease,"Organelle biogenesis and maintenance","Developmental Biology","Neuronal System","Vesicle-media
ted transport","Extracellular matrix organization","Cellular responses to external stimuli","Metabolism of RNA","Programmed Cell Death","DNA Repair","Circadian Clock","Metabolism of proteins","Muscle 
contraction","Transport of small molecules",Hemostasis,"Signaling by Receptor Tyrosine Kinases",Mitotic,"RNA Polymerase II Transcription","Innate Immune System","Metabolism of carbohydrates","Metaboli
sm of lipids","Cell Cycle Checkpoints","Adaptive Immune System","Intracellular signaling by second messengers","Cytokine Signaling in Immune system","Diseases of signal transduction by growth factor r
eceptors and second messengers","MAPK family signaling cascades","Signaling by GPCR","Cilium Assembly","Nervous system development","Transmission across Chemical Synapses","Infectious disease","Membra
ne Trafficking","Non-integrin membrane-ECM interactions","Signaling by Non-Receptor Tyrosine Kinases","Signaling by Rho GTPases","Cellular responses to stress","rRNA processing",Apoptosis,"Signaling b
y Hippo","Signaling by Hedgehog","DNA Double-Strand Break Repair","Unfolded Protein Response (UPR)","Cardiac conduction","MTOR signalling","Ion channel transport","Cell surface interactions at the vas
cular wall","Platelet homeostasis","Signaling by Insulin receptor","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Toll-like Receptor Cascades","Glycogen metabolism","Phospholi
pid metabolism","G2/M Checkpoints","TCR signaling","DAG and IP3 signaling","Signaling by Interleukins","Oncogenic MAPK signaling","MAPK1/MAPK3 signaling","Signaling by NTRKs","GPCR downstream signalli
ng","PIP3 activates AKT signaling","Signaling by VEGF","Anchoring of the basal body to the plasma membrane","Axon guidance","Neurotransmitter receptors and postsynaptic signal transmission","Fcgamma r
eceptor (FCGR) dependent phagocytosis","Sphingolipid metabolism","Signaling by FGFR in disease","Signaling by KIT in disease","HIV Infection","trans-Golgi Network Vesicle Budding","Leishmania infectio
n","Signaling by PTK6","Signaling by PDGFR in disease","FLT3 signaling in disease","RHO GTPase Effectors","Mitotic G2-G2/M phases","Influenza Infection","SARS-CoV Infections","Response of EIF2AK4 (GCN
2) to amino acid deficiency","Cellular Senescence","rRNA processing in the nucleus and cytosol","Caspase activation via extrinsic apoptotic signalling pathway","Clathrin-mediated endocytosis","Hedgeho
g 'on' state","Homology Directed Repair","IRE1alpha activates chaperones","Ion homeostasis","Neutrophil degranulation","mTORC1-mediated signalling","Interferon Signaling","Stimuli-sensing channels","S
ignaling by SCF-KIT","Nitric oxide stimulates guanylate cyclase","M Phase","Regulation of lipid metabolism by PPARalpha","Insulin receptor signalling cascade","G0 and Early G1","Transcriptional Regula
tion by TP53","Toll Like Receptor 5 (TLR5) Cascade","Glycogen breakdown (glycogenolysis)","PI Metabolism","G2/M DNA damage checkpoint","Generation of second messenger molecules","CaM pathway","Interle
ukin-2 family signaling","Signaling by RAS mutants","RAF/MAP kinase cascade","Signaling by NTRK1 (TRKA)","Signaling by NTRK3 (TRKC)","G alpha (q) signalling events","Negative regulation of the PI3K/AK
T network","VEGFA-VEGFR2 Pathway","Semaphorin interactions","Activation of NMDA receptors and postsynaptic events","Role of phospholipids in phagocytosis","Sphingolipid de novo biosynthesis","RET sign
aling","Signaling by FGFR1 in disease","Signaling by FGFR2 in disease","Drug resistance of KIT mutants","Host Interactions of HIV factors","Golgi Associated Vesicle Biogenesis","Leishmania parasite gr
owth and survival","PTK6 promotes HIF1A stabilization","Drug resistance of PDGFR mutants","Signaling by FLT3 ITD and TKD mutants","RHO GTPases activate PKNs","G2/M Transition","NS1 Mediated Effects on
 Host Pathways","SARS-CoV-1 Infection","Transcriptional Regulation by VENTX","EPH-Ephrin signaling","PTEN Regulation","L1CAM interactions","Oxidative Stress Induced Senescence","Major pathway of rRNA 
processing in the nucleolus and cytosol","Caspase activation via Dependence Receptors in the absence of ligand","Toll Like Receptor 4 (TLR4) Cascade","Cargo recognition for clathrin-mediated endocytos
is","Parasite infection","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","VEGF ligand-receptor interactions","G alpha (i) signalling events","Interleukin-1 family signali
ng","Antiviral mechanism by IFN-stimulated genes","cGMP effects","Mitotic Metaphase and Anaphase","Transcriptional regulation by RUNX1","Interferon alpha/beta signaling","Toll Like Receptor 2 (TLR2) C
ascade","PPARA activates gene expression","Signaling by FGFR3 in disease","G1 Phase","RHO GTPases activate PAKs","G alpha (z) signalling events","IRS-mediated signalling","Regulation of TP53 Activity"
,"MyD88 cascade initiated on plasma membrane","Synthesis of PIPs at the plasma membrane","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Calmodulin induced events","Interleukin-2 sig
naling","Signaling downstream of RAS mutants","Activation of TRKA receptors","Activated NTRK3 signals through PI3K","Gastrin-CREB signalling pathway via PKC and MAPK",PI5P,"PP2A and IER3 Regulate PI3K
/AKT Signaling","Sema4D in semaphorin signaling","Post NMDA receptor activation events","FGFR1 mutant receptor activation","FGFR2 mutant receptor activation","Interleukin-15 signaling","Dasatinib-resi
stant KIT mutants","The role of Nef in HIV-1 replication and disease pathogenesis","Anti-inflammatory response favouring Leishmania parasite infection","Signalling to ERKs","Imatinib-resistant PDGFR m
utants","STAT5 activation downstream of FLT3 ITD mutants","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Centrosome maturation","RAS processing","In
hibition of PKR","SARS-CoV-1 Genome Replication and Transcription","EPHB-mediated forward signaling","Regulation of PTEN stability and activity","Recycling pathway of L1","MyD88-independent TLR4 casca
de","Leishmania phagocytosis","HDR through Homologous Recombination (HRR)","VEGF binds to VEGFR leading to receptor dimerization","Visual phototransduction","Interleukin-1 signaling","ISG15 antiviral 
mechanism","Ephrin signaling","Mitotic Anaphase","RUNX1 regulates transcription of genes involved in BCR signaling","Regulation of IFNA signaling","Toll Like Receptor TLR6:TLR2 Cascade","Signaling by 
FGFR3 point mutants in cancer","Synthesis of PIPs at the Golgi membrane","Cyclin D associated events in G1","VEGFR2 mediated cell proliferation","PI3K Cascade","Regulation of TP53 Expression and Degra
dation","MAP kinase activation","PKA-mediated phosphorylation of CREB","NGF-independant TRKA activation","EGFR Transactivation by Gastrin","Regulation of TP53 Activity through Phosphorylation","Sema4D
 mediated inhibition of cell attachment and migration","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Activation of AMPK downstream of NMDARs","Signaling by activa
ted point mutants of FGFR1","Activated point mutants of FGFR2","Nef and signal transduction","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-me
diated IL10 synthesis","Prolonged ERK activation events","Activation of RAC1 downstream of NMDARs","Loss of proteins required for interphase microtubule organization from the centrosome","Replication 
of the SARS-CoV-1 genome","Signalling to RAS","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3A-mediated phagocytosis","Sema4D induced cell migration and growth-cone collapse","Homologous DNA Pairing and
 Strand Exchange","The phototransduction cascade","ADORA2B mediated anti-inflammatory cytokines production","Regulation of TP53 Activity through Acetylation","Signaling by cytosolic FGFR1 fusion mutan
ts","Separation of Sister Chromatids","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","FGFR3 mutant receptor activation","Long-term potentiation","Regulation of TP53 Degradation","MAPK targets
/ Nuclear events mediated by MAP kinases","PKA activation","Ras activation upon Ca2+ influx through NMDA receptor","PKB-mediated events","Nef Mediated CD4 Down-regulation","ARMS-mediated activation","
Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK activation","p38MAPK events","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Presynaptic phase of homologous DNA pairing
 and strand exchange",Inactivation,"recovery and regulation of the phototransduction cascade","PI5P Regulates TP53 Acetylation","RSK activation","JNK (c-Jun kinases) phosphorylation and  activation me
diated by activated human TAK1","IKK complex recruitment mediated by RIP1","Signaling by activated point mutants of FGFR3","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Activation of
 the AP-1 family of transcription factors","PDE3B signalling","CREB phosphorylation"}

> <broad_targets>
{FLT3,PRKCG}

> <broad_moa>
{"FLT3 inhibitor","KIT inhibitor","PKC inhibitor"}

> <synonyms>
{Midostaurin,PKC412,120685-11-2,120685112,"Cgp 41251",Benzoylstaurosporine,PKC-412,"PKC 412",4'-N-Benzoylstaurosporine,4'NBenzoylstaurosporine,CGP-41251,CGP41251,RYDAPT,UNII-ID912S5VON,UNIIID912S5VON,
ID912S5VON,CHEMBL608533,CHEBI:63452,"Cgp 41 251","Midostaurin (USAN:INN)","Rydapt (TN)",Midostaurin(PKC412),"EMD 539648",EI-370,539648}

> <pdid>
PD021374

> <targets>
{"multi kinase",PKC}

> <classes>
{}

> <pubchem_cids>
{9829523}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -7.7905   -6.0071    0.0000 O   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -7.7905   -3.0071    0.0000 O   0  0
   -5.1925   -3.0071    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  1  0
 15 17  2  0
 17 10  1  0
  7 18  2  0
 18  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28116

> <plate>
Kinase v5-1

> <well>
E21

> <supplier_cmpd_name>
Piceatannol

> <ctcr_id>
7259

> <supplier_cmpd_id>
EI-271

> <smiles>
Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1

> <pd_targets>
{THRB,PMP22,CDPK,LCK,MYLK,SMN1,L3MBTL1,NPC1,KDM4E,SYK,LMNA,TDP1,MAPT,BLM,DYRK1A,ALOX12,HPGD,POLB,ALDH1A1,FFP,KMT2A,MEN1,GMNN,TGR,ALD,STK33,GFER,ALOX5,MTOR,GLO1,MARK4,PRKCQ,DYRK1B,CSNK1A1,ALK,RET,MAP4K
4,LRRK2,CLK2,CAMK2A,STK3,ROCK2,SGK2,ROS1,PTK2,PRKX,GRK5,TAOK1,GSK3A,SIK2,TYRO3,HCK,CAMKK2,JAK3,PIM1,ROCK1,PRKACA,CAMK1D,MAPK10,JAK2,TNK2,FGFR1,MELK,PDGFRA,TBK1,LTK,MARK3,ACVR1,BTK,CDK8,IKBKE,MAP3K10,R
PS6KA3,GSK3B,FLT1,CASP6}

> <pathway_gtopdb>
{"Transcription factor","Unclassified protein",Enzyme,"Epigenetic regulator",Transporter,"Other nuclear protein","Other cytosolic protein","Nuclear receptor",Kinase,Reader,Eraser,Hydrolase,Oxidoreduct
ase,Transferase,Lyase,"Nuclear hormone receptor subfamily 1","Protein Kinase","Methyl-lysine/arginine binding protein","Lysine demethylase",Bromodomain,"Nuclear hormone receptor subfamily 1 group A","
CAMK protein kinase group","TK protein kinase group","Tudor domain","MBT domain","Jumonji domain-containing","CMGC protein kinase group","Atypical protein kinase group","Nuclear hormone receptor subfa
mily 1 group A member 2","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Src family","CAMK protein kinase MLCK family","Tyrosine protein kinase Syk family","CMGC protein kinase DYRK family
","CAMK protein kinase unique family","Atypical protein kinase PIKK family","CMGC protein kinase Dyrk1 subfamily","Atypical protein kinase FRAP subfamily",Protease,"Cysteine protease","AGC protein kin
ase group","CK1 protein kinase group","TKL protein kinase group","STE protein kinase group","Other protein kinase group","Cysteine protease CD clan","AGC protein kinase PKC family","CK1 protein kinase
 CK1 family","TKL protein kinase STKR family","Tyrosine protein kinase Ret family","STE protein kinase STE20 family","TKL protein kinase LRRK family","CMGC protein kinase CLK family","CAMK protein kin
ase CAMK2 family","AGC protein kinase DMPK family","AGC protein kinase SGK family","Tyrosine protein kinase Sev family","Tyrosine protein kinase Fak family","AGC protein kinase PKA family","AGC protei
n kinase GRK family","CMGC protein kinase GSK family","Tyrosine protein kinase Axl family","Other protein kinase CAMKK family","Tyrosine protein kinase JakA family","CAMK protein kinase PIM family","C
MGC protein kinase MAPK family","Tyrosine protein kinase Ack family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family","Other protein kinase IKK family","Tyrosine protein ki
nase Alk family","Tyrosine protein kinase Tec family","CMGC protein kinase CDK family","TKL protein kinase MLK family","AGC protein kinase RSK family","Tyrosine protein kinase VEGFR family","Cysteine 
protease C14 family","CAMK protein kinase MARK subfamily","AGC protein kinase PKC delta subfamily","TKL protein kinase STKR Type 1 subfamily","STE protein kinase MSN subfamily","STE protein kinase MST
 subfamily","AGC protein kinase ROCK subfamily","AGC protein kinase GRK subfamily","STE protein kinase TAO subfamily","CAMK protein kinase QIK subfamily","Other protein kinase Meta subfamily","CMGC pr
otein kinase JNK subfamily","CAMK protein kinase MELK subfamily","TKL protein kinase STKR1","CMGC protein kinase CDK8 subfamily","TKL protein kinase MLK subfamily","AGC protein kinase RSK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Nuclear hormone receptors","Catalytic receptors","Kinases (EC 2.7.x.x)","SLC superfamily of solute carriers","Chromatin modifying enzymes","Eicosanoid turnover","1A. T
hyroid hormone receptors","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","SLC65 NPC-type cholesterol transporters","1.14.11.- Histone demethylases","CMGC: Containing CDK",MAPK
,GSK3,"CLK families",Lipoxygenases,"Prostaglandin synthases",Atypical,"TK: Tyrosine kinase","Myosin Light Chain Kinase (MLCK) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (D
YRK) family","CAMK-unique family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Non-receptor tyrosine kinases (nRTKs)","Dyrk1 subfamily","FRAP subfamily","Src family","Syk family","
Peptidases and proteinases","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CD: Cysteine (C) Peptidases","CAMK-lik
e (CAMKL) family","Protein kinase C (PKC) family","Casein kinase 1 (CK1) family","STE20 family","TKL: Tyrosine kinase-like","CLK family","CAMK2 family","DMPK family","SGK family","Protein kinase A (PK
A) family","G protein-coupled receptor kinases (GRKs)","Glycogen synthase kinase (GSK) family","Other protein kinases","PIM family","CAMK1 family","Mitogen-activated protein kinases (MAP kinases)","Cy
clin-dependent kinase (CDK) family","RSK family","C14: Caspase","MARK subfamily","Delta subfamily","Receptor tyrosine kinases (RTKs)","MSN subfamily","Leucine-rich repeat kinase (LRRK) family","MST su
bfamily","Rho kinase","GRK4 subfamily","TAO subfamily","GSK subfamily","QIK subfamily","CAMKK family","JNK subfamily","MELK subfamily","IKK family","Receptor serine/threonine kinase (RSTK) family","CD
K8 subfamily","Mixed Lineage Kinase (MLK) family","RSK subfamily","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XIV RTKs: RET","Type XVII RTKs: ROS receptors","Fak family","Ty
pe XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Meta subfamily","Janus kinase (JakA) family","Ack family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDG
FR",CSFR,Kit,"FLT3 receptor family","Type I receptor serine/threonine kinases","Tec family","MLK subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Metabolism of proteins","Developmental Biology",Disease,"Signal Transduction","Metabolism of RNA","Gene expression (Transcription)","Transport of small molecules","Cell Cycle","DNA Repair","Neuronal
 System",Metabolism,"Protein localization","Post-translational protein modification","Nervous system development","Infectious disease","Signaling by Rho GTPases","Metabolism of non-coding RNA","RNA Po
lymerase II Transcription","Plasma lipoprotein assembly",remodeling,"and clearance",Mitotic,"DNA Double-Strand Break Repair","Transmission across Chemical Synapses","Metabolism of lipids","Base Excisi
on Repair","Biological oxidations","Mitochondrial protein import","The citric acid (TCA) cycle and respiratory electron transport",SUMOylation,"EGR2 and SOX10-mediated initiation of Schwann cell myeli
nation","HIV Infection","RHO GTPase Effectors","snRNP Assembly","Generic Transcription Pathway","Plasma lipoprotein clearance","Leishmania infection","M Phase","Nonhomologous End-Joining (NHEJ)","Neur
otransmitter receptors and postsynaptic signal transmission","Homology Directed Repair","Mitotic G1 phase and G1/S transition","Biosynthesis of specialized proresolving mediators (SPMs)","Resolution o
f Abasic Sites (AP sites)","Phase I - Functionalization of compounds","Pyruvate metabolism and Citric Acid (TCA) cycle","SUMO E3 ligases SUMOylate target proteins","Host Interactions of HIV factors","
RHO GTPases activate PAKs","Transcriptional Regulation by TP53","LDL clearance","Leishmania parasite growth and survival","Mitotic Metaphase and Anaphase","Activation of NMDA receptors and postsynapti
c events","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","G0 and Early G1","Biosynthesis of DPA-derived SPMs","Biosynthesis of DHA-derived SPMs","Resolution of AP sites 
via the multiple-nucleotide patch replacement pathway","Ethanol oxidation","G1/S Transition","Pyruvate metabolism","SUMOylation of intracellular receptors","The role of Nef in HIV-1 replication and di
sease pathogenesis","Regulation of TP53 Activity","Anti-inflammatory response favouring Leishmania parasite infection","Mitotic Anaphase","Post NMDA receptor activation events","HDR through Homologous
 Recombination (HRR)","Biosynthesis of DPAn-3 SPMs","Biosynthesis of D-series resolvins","PCNA-Dependent Long Patch Base Excision Repair","Activation of the pre-replicative complex","Nef-mediates down
 modulation of cell surface receptors by recruiting them to clathrin adapters","Regulation of TP53 Activity through Methylation","FCGR3A-mediated IL10 synthesis","Nuclear Envelope (NE) Reassembly","Ac
tivation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","Biosynthesis of DPAn-3-derived maresins","Biosynthesis of DPAn-3-derived 13-series resolvins","Regulation of TP53 E
xpression and Degradation","Nef Mediated CD4 Down-regulation","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 De
gradation","Organelle biogenesis and maintenance","Cellular responses to external stimuli","Immune System","Cilium Assembly","Signaling by GPCR","Diseases of signal transduction by growth factor recep
tors and second messengers","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases","Signaling by Hippo","Ion channel transport","Cytokine Signaling in Immune system","Innate Immun
e System","Signaling by Receptor Tyrosine Kinases","Anchoring of the basal body to the plasma membrane","GPCR downstream signalling","Signaling by WNT in cancer","Axon guidance","Cellular Senescence",
"Signaling by PTK6","Stimuli-sensing channels","SARS-CoV Infections","Signaling by Interleukins","FLT3 signaling in disease","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Signaling by FGFR i
n disease","Signaling by PDGFR in disease","Oncogenic MAPK signaling","Signaling by NOTCH1 in Cancer","Signaling by VEGF","G alpha (i) signalling events","Signaling by AMER1 mutants","RET signaling","
Oxidative Stress Induced Senescence","PTK6 promotes HIF1A stabilization","Semaphorin interactions","Parasite infection","G alpha (q) signalling events","SARS-CoV-1 Infection","Interleukin-2 family sig
naling","Signaling by FLT3 ITD and TKD mutants","G2/M Transition","Toll Like Receptor 5 (TLR5) Cascade","G1 Phase","Signaling by FGFR1 in disease","Drug resistance of PDGFR mutants","Toll Like Recepto
r 4 (TLR4) Cascade","Signaling by RAS mutants","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","VEGF ligand-receptor interactions","Visual phototransduction","Truncations of AMER1 destabilize t
he destruction complex","Sema4D in semaphorin signaling","Leishmania phagocytosis","SARS-CoV-1 Genome Replication and Transcription","Interleukin-15 signaling","STAT5 activation downstream of FLT3 ITD
 mutants","Centrosome maturation","MyD88 cascade initiated on plasma membrane","Cyclin D associated events in G1","FGFR1 mutant receptor activation","Imatinib-resistant PDGFR mutants","MyD88-independe
nt TLR4 cascade","Signaling downstream of RAS mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","VEGF binds to VEGFR leading to receptor dimerization","TP53 Regulates Transcription of
 Cell Death Genes","The phototransduction cascade","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Sema4D induced cell migration and growth-cone collapse","FCGR3A-m
ediated phagocytosis","ADORA2B mediated anti-inflammatory cytokines production","Separation of Sister Chromatids","Replication of the SARS-CoV-1 genome","Nef and signal transduction","Loss of proteins
 required for interphase microtubule organization from the centrosome","MAP kinase activation","Signaling by activated point mutants of FGFR1","TRIF(TICAM1)-mediated TLR4 signaling","TP53 Regulates Tr
anscription of Caspase Activators and Caspases",Inactivation,"recovery and regulation of the phototransduction cascade","Ras activation upon Ca2+ influx through NMDA receptor","Loss of Nlp from mitoti
c centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Activation of the AP-1 family of transcription factors","CREB phosphorylat
ion"}

> <broad_targets>
{ATP5A1,ATP5B,ATP5C1,IRF3}

> <broad_moa>
{"SYK inhibitor"}

> <synonyms>
{piceatannol,10083-24-6,10083246,3-Hydroxyresveratol,3Hydroxyresveratol,"3,5,3',4'-Tetrahydroxystilbene","3,5,3',4'Tetrahydroxystilbene","(E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol","(E)4(3,5dihydrox
ystyryl)benzene1,2diol","3,3',4'5-Tetrahydroxystilbene","3,3',4'5Tetrahydroxystilbene","4-((E)-2-(3,5-dihydroxyphenyl)ethenyl)benzene-1,2-diol","4((E)2(3,5dihydroxyphenyl)ethenyl)benzene1,2diol","3,3'
,4,5'-Tetrahydroxystilbene","3,3',4,5'Tetrahydroxystilbene",EI-271,S3026,Piceatannol}

> <pdid>
PD002653

> <targets>
{Syk,Others}

> <classes>
{}

> <pubchem_cids>
{667639}

$$$$
UTKinase_V5
  SciTegic11012413002D

 16 16  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  3
    1.2947   -3.7531    0.0000 O   0  5
   -1.3032   -3.7490    0.0000 O   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -1.3101    6.7502    0.0000 N   0  0
   -2.6024    2.9967    0.0000 C   0  0
   -3.9001    2.2444    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  8 10  2  0
  4 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  3  0
 12 15  1  0
 15 16  3  0
M  CHG  2   8   1   9  -1
M  END
> <name>
UTKinase_V5

> <id>
28117

> <plate>
Kinase v5-1

> <well>
G03

> <supplier_cmpd_name>
AG-126

> <ctcr_id>
4689

> <supplier_cmpd_id>
EI-263

> <smiles>
Oc1cc(ccc1[N+]([O-])=O)C=C(C#N)C#N

> <pd_targets>
{HSD17B10,PYK,MAPT,ALDH1A1,FFP,POLB,ALD,BLM,CYP2C9,KDM4E,RORC,TDP1,LMNA,RECQL,HPGD,CYP1A2,CYP3A4}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator","Transcription factor","Other nuclear protein",Oxidoreductase,Transferase,"Cytochrome P450",Eraser,"Nuclear receptor",Hydrolase,"Cytochrome P45
0 family 2","Lysine demethylase","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 1","Cytochrome P450 family 3","Cytochrome P450 family 2C","Jumonji domain-containing","Nuclear hormone r
eceptor subfamily 1 group F","Cytochrome P450 family 1A","Cytochrome P450 family 3A","Cytochrome P450 2C9","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 1A1","Cytochrome P45
0 3A4"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Chromatin modifying enzymes","Nuclear hormone receptors","Eicosanoid turnover","CYP2 family: drug metabolising subset","1.14.11.- Histone demethylases","1F. Retin
oic acid-related orphans","Prostaglandin synthases","CYP1 family","CYP3 family"}

> <pathway_reactome>
{Metabolism,"Neuronal System","DNA Repair","Gene expression (Transcription)","Cell Cycle","Metabolism of amino acids and derivatives","Transmission across Chemical Synapses","Biological oxidations","B
ase Excision Repair","DNA Double-Strand Break Repair","RNA Polymerase II Transcription",Mitotic,"Metabolism of lipids","Branched-chain amino acid catabolism","Neurotransmitter receptors and postsynapt
ic signal transmission","Phase I - Functionalization of compounds","Resolution of Abasic Sites (AP sites)","Homology Directed Repair","Generic Transcription Pathway","Nonhomologous End-Joining (NHEJ)"
,"M Phase","Biosynthesis of specialized proresolving mediators (SPMs)","Activation of NMDA receptors and postsynaptic events","Ethanol oxidation","Resolution of AP sites via the multiple-nucleotide pa
tch replacement pathway","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Cytochrome P450 - arranged by substrate type","Transcriptional regulation by RUNX3","Mitotic Met
aphase and Anaphase","Biosynthesis of DHA-derived SPMs","Post NMDA receptor activation events","PCNA-Dependent Long Patch Base Excision Repair","HDR through Homologous Recombination (HRR)",Xenobiotics
,"RUNX3 Regulates Immune Response and Cell Migration","Mitotic Anaphase","Biosynthesis of D-series resolvins","Biosynthesis of maresins","Activation of AMPK downstream of NMDARs","Homologous DNA Pairi
ng and Strand Exchange","CYP2E1 reactions","Nuclear Envelope (NE) Reassembly","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of maresin-like SPMs","Presynaptic phase 
of homologous DNA pairing and strand exchange","Initiation of Nuclear Envelope (NE) Reformation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{G12,118409-62-4,118409624,AG-126,AG126,"AG 126","Tyrphostin AG 126",ag126,alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile,alphaCyano(3hydroxy4nitro)cinnamonitrile,"Tyrphostin AG126",UNII-7YA4AMD1JC,UNI
I7YA4AMD1JC,2-((3-hydroxy-4-nitrophenyl)methylidene)propanedinitrile,2((3hydroxy4nitrophenyl)methylidene)propanedinitrile,7YA4AMD1JC,Propanedinitrile,((3-hydroxy-4-nitrophenyl),((3hydroxy4nitrophenyl)
,T4092,EI-263}

> <pdid>
PD014824

> <targets>
{IRAK,ERK}

> <classes>
{MAPK/ERK Pathway,Stem Cell/Wnt}

> <pubchem_cids>
{2046}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 21  0  0  0  0            999 V2000
    5.1937   -3.0093    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.2941   -3.7521    0.0000 C   0  0
   -0.0063   -4.4998    0.0000 N   0  0
    3.8912   -5.2578    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    6.4869   -6.7636    0.0000 N   0  0
    2.5901   -6.0060    0.0000 C   0  0
    1.2898   -6.7537    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12  8  1  0
 12 13  2  0
 13  5  1  0
  3 14  1  0
 14 15  3  0
  2 16  2  3
 16 17  1  0
 17 18  3  0
 16 19  1  0
 19 20  3  0
M  END
> <name>
UTKinase_V5

> <id>
28118

> <plate>
Kinase v5-1

> <well>
G05

> <supplier_cmpd_name>
AG-370

> <ctcr_id>
7688

> <supplier_cmpd_id>
EI-229

> <smiles>
NC(/C(=C/c1ccc2[nH]ccc2c1)C#N)=C(C#N)C#N

> <pd_targets>
{ALDH1A1,MAPT}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein",Oxidoreductase}

> <pathway_chembl>
{}

> <pathway_reactome>
{Metabolism,"Neuronal System","Biological oxidations","Transmission across Chemical Synapses","Phase I - Functionalization of compounds","Neurotransmitter receptors and postsynaptic signal transmissio
n","Ethanol oxidation","Activation of NMDA receptors and postsynaptic events","Post NMDA receptor activation events","Activation of AMPK downstream of NMDARs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{G37,AG-370,AG370,NSC651712,"(3Z)-2-amino-4-(1H-indol-5-yl)buta-1,3-diene-1,1,3-tricarbonitrile","(3Z)2amino4(1Hindol5yl)buta1,3diene1,1,3tricarbonitrile","TYRPHOSTIN B7",BiomolKI_000027,BiomolKI00002
7,BiomolKI-000027,"BiomolKI 000027",BiomolKI2_000035,BiomolKI2000035,BiomolKI2-000035,"BiomolKI2 000035",BMK1-D3,BMK1D3,BSPBio_001394,BSPBio001394,BSPBio-001394,"BSPBio 001394",CHEMBL59150,BCBcMAP01_0
00042,BCBcMAP01000042,BCBcMAP01-000042,"BCBcMAP01 000042",CHEBI:92578,HMS1361F16,HMS1362L15,HMS1791F16,HMS1792L15,HMS198,EI-229}

> <pdid>
PD020172

> <targets>
{PDGFRK}

> <classes>
{}

> <pubchem_cids>
{5328748}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 22  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 C   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 C   0  0
    3.8975   -2.2510    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -1.3101    6.7502    0.0000 N   0  0
   -2.6039    2.9994    0.0000 C   0  0
   -2.6039    1.4994    0.0000 N   0  0
   -3.9032    3.7490    0.0000 S   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.5988   -1.5004    0.0000 C   0  0
   -3.8983   -0.7513    0.0000 C   0  0
   -2.5983   -3.0004    0.0000 C   0  0
   -3.8975   -2.2510    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  3  0
  9 12  1  0
 12 13  1  0
 12 14  2  0
  7 15  2  0
 15 16  1  0
 16 17  2  0
 17  5  1  0
 17 18  1  0
 16 19  1  0
 19 20  1  0
 19 21  1  0
 19 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28119

> <plate>
Kinase v5-1

> <well>
G07

> <supplier_cmpd_name>
AG-879

> <ctcr_id>
3991

> <supplier_cmpd_id>
EI-258

> <smiles>
CC(C)(C)c1cc(C=C(C#N)C(N)=S)cc(c1O)C(C)(C)C

> <pd_targets>
{HSD17B10,MAPT,CYP2C19,HIF1A,PMP22,CHRM1,CYP2D6,CYP3A4,CYP1A2,TSHR,BLM,LMNA,ALDH1A1,LEF,THPO,GMNN,RECQL,KMT2A,MEN1,NFKB1,HPGD,CYP2C9,KDM4E,FTL,ALOX15,APEX1,MTOR,EPHA3}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Transcription factor","Unclassified protein","Membrane receptor","Other nuclear protein","Epigenetic regulator",Oxidoreductase,"Cytochrome P450","Family A G protein-
coupled receptor",Protease,Reader,Eraser,Kinase,"Cytochrome P450 family 2","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 1","Peptide receptor (family A G
PCR)","Metallo protease",Bromodomain,"Lysine demethylase","Protein Kinase","Cytochrome P450 family 2C","Monoamine receptor","Cytochrome P450 family 2D","Cytochrome P450 family 3A","Cytochrome P450 fam
ily 1A","Glycohormone receptor","Metallo protease MAE clan","Jumonji domain-containing","Atypical protein kinase group","TK protein kinase group","Cytochrome P450 2C19","Acetylcholine receptor","Cytoc
hrome P450 2D6","Cytochrome P450 3A4","Cytochrome P450 1A1","Metallo protease M34 family","Cytochrome P450 2C9","Atypical protein kinase PIKK family","Tyrosine protein kinase Eph family","Atypical pro
tein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","Chromatin modifying enzymes","Kinases (EC 2.7.x.x)","Catalytic receptors","CYP2 family: drug metabolising subs
et","Acetylcholine receptors (muscarinic)","CYP3 family","CYP1 family","Glycoprotein hormone receptors","Prostaglandin synthases","1.14.11.- Histone demethylases","2.1.1.43 Histone methyltransferases 
(HMTs)",Lipoxygenases,Atypical,"Receptor kinases","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","TK: Tyrosine kinase","FRAP subfamily","Receptor tyrosine kinases (RTKs)","Type XIII R
TKs: Ephrin receptor family"}

> <pathway_reactome>
{Metabolism,"Neuronal System","Cellular responses to external stimuli","Developmental Biology","Signal Transduction",Disease,"DNA Repair","Cell Cycle",Hemostasis,"Immune System","Gene expression (Tran
scription)","Vesicle-mediated transport","Metabolism of amino acids and derivatives","Transmission across Chemical Synapses","Biological oxidations","Cellular responses to stress","Nervous system deve
lopment","Signaling by GPCR","Metabolism of lipids","Infectious disease","DNA Double-Strand Break Repair",Mitotic,"Platelet activation","signaling and aggregation","Cytokine Signaling in Immune system
","RNA Polymerase II Transcription","Membrane Trafficking","Base Excision Repair","Branched-chain amino acid catabolism","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Fu
nctionalization of compounds","Cellular response to hypoxia","EGR2 and SOX10-mediated initiation of Schwann cell myelination","GPCR ligand binding","Biosynthesis of specialized proresolving mediators 
(SPMs)","Leishmania infection","Homology Directed Repair","M Phase","Uptake and actions of bacterial toxins","Platelet Aggregation (Plug Formation)","Mitotic G1 phase and G1/S transition","Signaling b
y Interleukins","Generic Transcription Pathway","trans-Golgi Network Vesicle Budding","Resolution of Abasic Sites (AP sites)","Axon guidance","Activation of NMDA receptors and postsynaptic events","Cy
tochrome P450 - arranged by substrate type","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Leishm
ania parasite growth and survival","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Mitotic Metaphase and Anaphase","Ethanol oxidation","Uptake and function of anthrax to
xins","G1/S Transition","Interleukin-1 family signaling","Transcriptional regulation by RUNX1","Golgi Associated Vesicle Biogenesis","Biosynthesis of DPA-derived SPMs","Resolution of AP sites via the 
multiple-nucleotide patch replacement pathway","Transcriptional Regulation by TP53","EPH-Ephrin signaling","Post NMDA receptor activation events",Xenobiotics,"Amine ligand-binding receptors","Biosynth
esis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","HDR through Homologous Recombination (HRR)","Mitotic Anaphase","Activation of the pre-replicative complex","Inte
rleukin-1 signaling","Biosynthesis of D-series resolvins","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Biosynthesis of DPAn-3 SPMs","PCNA-Dependent Long Pat
ch Base Excision Repair","Regulation of TP53 Activity","EPHA-mediated growth cone collapse","Activation of AMPK downstream of NMDARs","CYP2E1 reactions","Muscarinic acetylcholine receptors","Biosynthe
sis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","ADORA2B mediated anti-inflammatory cytokines production","Homologous DNA Pairing and Strand Exchange","Nuc
lear Envelope (NE) Reassembly","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of DPAn-3-derived protectins and resolvins","Regulation of TP53 Expression and Degradation","Presynaptic phase
 of homologous DNA pairing and strand exchange","Initiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation"}

> <broad_targets>
{ERBB2,KDR,NTRK1}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{G87,CBiol_001931,CBiol001931,CBiol-001931,"CBiol 001931",KBioGR_000118,KBioGR000118,KBioGR-000118,"KBioGR 000118",KBioSS_000118,KBioSS000118,KBioSS-000118,"KBioSS 000118",KBio2_000118,KBio2000118,KBi
o2-000118,"KBio2 000118",KBio2_002686,KBio2002686,KBio2-002686,"KBio2 002686",KBio2_005254,KBio2005254,KBio2-005254,"KBio2 005254",KBio3_000235,KBio3000235,KBio3-000235,"KBio3 000235",KBio3_000236,KBi
o3000236,KBio3-000236,"KBio3 000236",Bio1_000217,Bio1000217,Bio1-000217,"Bio1 000217",Bio1_000706,Bio1000706,Bio1-000706,"Bio1 000706",Bio1_001195,Bio1001195,Bio1-001195,"Bio1 001195",Bio2_000118,Bio2
000118,Bio2-000118,"Bio2 000118",Bio2_000598,Bio2000598,Bio2-000598,"Bio2 000598",HMS3651L13,AKOS025243758,ZINC100435325,AK167468,"AG 879 pound>>AG-879 pound>>AG879","AG 879 pound>>AG879 pound>>AG879"
,EI-258,S2816,AG-879,"Tyrphostin AG 879"}

> <pdid>
PD002600

> <targets>
{NGFRK,HER2}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{3036144}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8978   -0.7496    0.0000 C   0  0
   -5.1981   -1.4975    0.0000 C   0  0
   -6.4959   -0.7455    0.0000 C   0  0
   -6.4936    0.7545    0.0000 C   0  0
   -5.1933    1.5025    0.0000 C   0  0
   -3.8955    0.7504    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
  4 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28120

> <plate>
Kinase v5-1

> <well>
G09

> <supplier_cmpd_name>
LY 294002

> <ctcr_id>
4842

> <supplier_cmpd_id>
ST-420

> <smiles>
O=C1C=C(Oc2c1cccc2c3ccccc3)N4CCOCC4

> <pd_targets>
{BLM,LMNA,GMNN,ALDH1A1,SMN1,PMP22,KDM4E,PIK3CD,PIK3CB,PRKDC,PIK3CA,MTOR,PIK3CG,PLK1,PIK3R1,PIK3R2,PIK3C2B,PIM3,CYP2D6,CYP1A2,PIM1,NFKB1,CYP2C19,CYP3A4,PLK3,PDE2A,TSHR,BRD3,PLK2,HIF1A,ALOX15,THPO,CYP2C
9,BRD4,BRD2,PIK3C2A,HSD17B10,CDK8,PDE3A,PDE3B,GSK3B,CSNK2A1,CSNK2A2,CSNK2B,HTR2B,PDE5A,HTR2A,CACNA1C,CACNB2,HTR2C}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein","Unclassified protein","Epigenetic regulator","Other cytosolic protein","Membrane receptor","Transcription factor","Ion channel",Oxidoreductase,Reader,Eraser,Transferas
e,Kinase,Protease,"Cytochrome P450",Phosphodiesterase,"Family A G protein-coupled receptor","Voltage-gated ion channel","Methyl-lysine/arginine binding protein","Lysine demethylase","Protein Kinase","
Cysteine protease","Cytochrome P450 family 2","Cytochrome P450 family 1","Cytochrome P450 family 3","Phosphodiesterase 2","Peptide receptor (family A GPCR)",Bromodomain,"Phosphodiesterase 3","Small mo
lecule receptor (family A GPCR)","Phosphodiesterase 5","Voltage-gated calcium channel","Tudor domain","Jumonji domain-containing","Atypical protein kinase group","Other protein kinase group","CAMK pro
tein kinase group","Cysteine protease CA clan","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Cytochrome P450 family 2C","Cytochrome P450 family 3A","Phosphodiesterase 2A","Glycohormone rece
ptor","CMGC protein kinase group","Phosphodiesterase 3A","Monoamine receptor","Phosphodiesterase 5A","Atypical protein kinase PIKK family","Other protein kinase PLK family","CAMK protein kinase PIM fa
mily","Cysteine protease C1A family","Cytochrome P450 2D6","Cytochrome P450 1A1","Cytochrome P450 2C19","Cytochrome P450 3A4","Cytochrome P450 2C9","CMGC protein kinase CDK family","CMGC protein kinas
e GSK family","Other protein kinase CK2 family","Serotonin receptor","Atypical protein kinase FRAP subfamily","Other protein kinase PLK2","CMGC protein kinase CDK8 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Chromatin modifying enzymes","Kinases (EC 2.7.x.x)","Catalytic receptors","Glycerophospholipid turnover","Cytochrome P450","Cyclic nucleotide turnover/signalling","G protein-couple
d receptors","Eicosanoid turnover","1.14.11.- Histone demethylases","Lipid modifying kinases",Atypical,"Receptor kinases","Phosphatidylinositol kinases","CAMK: Calcium/calmodulin-dependent protein kin
ases","CYP2 family: drug metabolising subset","CYP1 family","CYP3 family",Phosphodiesterases,3',"5'-cyclic nucleotide (PDEs)","Glycoprotein hormone receptors","Enzymatic bromodomain-containing protein
s",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","5-Hydroxytryptamine receptors",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinase
s (PIKK) family","Other protein kinases","Phosphatidylinositol-4-phosphate 3-kinase family","PIM family","Bromodomain kinase (BRDK) family","Cyclin-dependent kinase (CDK) family","Glycogen synthase ki
nase (GSK) family","Other PIKK family kinases","FRAP subfamily","Polo-like kinase (PLK) family","CDK8 subfamily","GSK subfamily"}

> <pathway_reactome>
{"DNA Repair","Cell Cycle",Metabolism,"Metabolism of RNA","Developmental Biology","Immune System","Signal Transduction",Disease,"Gene expression (Transcription)",Hemostasis,"Cellular responses to exte
rnal stimuli","DNA Double-Strand Break Repair",Mitotic,"Biological oxidations","Metabolism of non-coding RNA","Nervous system development","Cytokine Signaling in Immune system","Signaling by Receptor 
Tyrosine Kinases","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Metabolism of lipids","Platelet homeostas
is","Infectious disease","Cellular responses to stress","Platelet activation","signaling and aggregation","Metabolism of amino acids and derivatives","Signaling by GPCR","Homology Directed Repair","M 
Phase","Mitotic G1 phase and G1/S transition","Phase I - Functionalization of compounds","snRNP Assembly","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Signaling by Interleukins","
Signaling by Insulin receptor","Cytosolic sensors of pathogen-associated DNA","Signaling by FGFR in disease","Generic Transcription Pathway","Phospholipid metabolism","Mitotic G2-G2/M phases","FLT3 si
gnaling in disease","Biosynthesis of specialized proresolving mediators (SPMs)","Nitric oxide stimulates guanylate cyclase","Leishmania infection","Cellular response to hypoxia","Platelet Aggregation 
(Plug Formation)","SARS-CoV Infections","Branched-chain amino acid catabolism","Signaling by NOTCH1 in Cancer","GPCR ligand binding","HDR through Homologous Recombination (HRR) or Single Strand Anneal
ing (SSA)","Mitotic Metaphase and Anaphase","G1/S Transition","Ethanol oxidation",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","STING mediated induction of 
host immune responses","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","PI Metabolism","G2/M Transition","Cytochrome P450 - arranged by substrate type","Signaling by FLT3 ITD and 
TKD mutants","Interleukin-1 family signaling","Biosynthesis of DHA-derived SPMs","cGMP effects","Leishmania parasite growth and survival","Oxygen-dependent proline hydroxylation of Hypoxia-inducible F
actor Alpha","Biosynthesis of DPA-derived SPMs","Potential therapeutics for SARS","Transcriptional regulation by RUNX3","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","SARS-CoV-1 Infection","C
lass A/1 (Rhodopsin-like receptors)","HDR through Homologous Recombination (HRR)","Mitotic Anaphase","Activation of the pre-replicative complex","Interleukin receptor SHC signaling","IRS-mediated sign
alling","IRF3-mediated induction of type I IFN","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Synthesis of PIPs at the plasma membrane","Centrosome maturation",Xenobiotics,"STAT5 a
ctivation downstream of FLT3 ITD mutants","Interleukin-1 signaling","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","Biosynthesis of DPAn-3 SPMs","RUNX3
 regulates p14-ARF","Synthesis of PIPs at the early endosome membrane","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","SARS-CoV-1 Genome Replication and Transcription","Amine ligand-binding
 receptors","Homologous DNA Pairing and Strand Exchange","Nuclear Envelope (NE) Reassembly","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation"
,"Loss of proteins required for interphase microtubule organization from the centrosome","CYP2E1 reactions","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent 
MAPK1/3 activation","Biosynthesis of maresin-like SPMs","Regulation of TP53 Activity through Phosphorylation","ADORA2B mediated anti-inflammatory cytokines production","CD163 mediating an anti-inflamm
atory response","Biosynthesis of DPAn-3-derived protectins and resolvins","Replication of the SARS-CoV-1 genome","Serotonin receptors","Presynaptic phase of homologous DNA pairing and strand exchange"
,"Initiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{AKT1,CHEK1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,MTOR,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PLK1,PRKCA,PRKDC,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"DNA dependent protein kinase inhibitor","mTOR inhibitor","phosphodiesterase inhibitor","PI3K inhibitor","PLK inhibitor"}

> <synonyms>
{154447-36-6,154447366,LY294002,"LY 294002",LY-294002,2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one,2(4Morpholinyl)8phenyl4H1benzopyran4one,2-morpholino-8-phenyl-4H-chromen-4-one,2morpholino8phenyl
4Hchromen4one,2-morpholin-4-yl-8-phenyl-4H-chromen-4-one,2morpholin4yl8phenyl4Hchromen4one,UNII-31M2U1DVID,UNII31M2U1DVID,2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one,2(morpholin4yl)8phenyl4Hchromen4o
ne,31M2U1DV,T4079,T2008,"EMD 440202",S1105,ST-420,"LY-294002 hydrochloride",440202}

> <pdid>
PD007784

> <targets>
{PI3K,"PI 3-K",Apoptosis,Autophagy,"Casein Kinase",DNA-PK}

> <classes>
{Apoptosis,Autophagy,Cell Cycle/DNA Damage,PI3K/Akt/mTOR,Stem Cell/Wnt}

> <pubchem_cids>
{3973}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  1  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 O   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    1.2990    0.7500    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -2.8161   -2.7592    0.0000 C   0  0
   -4.1721   -3.4005    0.0000 O   0  0
   -1.6025   -3.6408    0.0000 C   0  0
   -0.2322   -3.0307    0.0000 C   0  0
    0.9817   -3.9122    0.0000 C   0  0  1  0  0  0
    0.8249   -5.4040    0.0000 C   0  0
   -0.5454   -6.0141    0.0000 C   0  0  1  0  0  0
    0.5781   -7.0080    0.0000 C   0  0
   -1.7589   -5.1324    0.0000 C   0  0  1  0  0  0
   -2.9548   -6.0289    0.0000 C   0  0
   -2.4822   -7.4525    0.0000 C   0  0
   -0.9822   -7.4429    0.0000 C   0  0
   -0.0861   -8.6458    0.0000 O   0  0
    2.3515   -3.2988    0.0000 O   0  0
    3.5681   -4.1775    0.0000 C   0  0
    3.4150   -5.6697    0.0000 C   0  0
    4.9371   -3.5645    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0  1  0  0  0
    1.2390   -2.3456    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  4  3  1  6
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  3
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  1
 18 20  1  0
 20 14  1  0
 20 21  1  1
 21 22  1  0
 22 23  1  0
 23 18  1  0
 23 24  2  0
 16 25  1  6
 25 26  1  0
 26 27  1  0
 26 28  2  0
 15 29  1  0
 29  4  1  0
 29 30  1  1
 29 31  1  0
 31  8  1  0
 31 11  2  0
M  END
> <name>
UTKinase_V5

> <id>
28121

> <plate>
Kinase v5-1

> <well>
G11

> <supplier_cmpd_name>
Wortmannin

> <ctcr_id>
6730

> <supplier_cmpd_id>
ST-415

> <smiles>
COC[C@H]1OC(=O)c2coc3C(=O)C4=C([C@@H](C[C@@]5(C)[C@H]4CCC5=O)OC(C)=O)[C@]1(C)c23

> <pd_targets>
{THRB,PRKDC,PIK3CA,PIK3CD,PLK1,PIK3CB,PIK3CG,MAPT,ALDH1A1,ABCB11,MYLK,MTOR,PIK3R1,IMPA1,PI4KA,PI4KB,PLK3,FFP,RECQL,HSP90AA1,ABCC2,ABCC4,LMNA,RORC,KMT2A,MEN1,PMP22,GAA,NPSR1,NFO,GMNN,HPGD}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Other cytosolic protein",Transporter,"Unclassified protein","Nuclear receptor",Kinase,Transferase,Oxidoreductase,"Primary active transporter",Hydrolase,"Nuclear hormone
 receptor subfamily 1","Protein Kinase","ATP-binding cassette","Nuclear hormone receptor subfamily 1 group A","Atypical protein kinase group","Other protein kinase group","ABCB subfamily","CAMK protei
n kinase group","ABCC subfamily","Nuclear hormone receptor subfamily 1 group A member 2","Atypical protein kinase PIKK family","Other protein kinase PLK family","CAMK protein kinase MLCK family","Atyp
ical protein kinase FRAP subfamily","Other nuclear protein","Epigenetic regulator","Membrane receptor",Reader,"Family A G protein-coupled receptor",Bromodomain,"Peptide receptor (family A GPCR)","Nucl
ear hormone receptor subfamily 1 group F","Short peptide receptor (family A GPCR)","Nuclear hormone receptor subfamily 1 group F member 3","Neuropeptide receptor"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Other protein targets","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Catalytic receptors","ATP-binding cassette transporter family","Inositol phosphate turnover"
,"Heat shock proteins","1A. Thyroid hormone receptors",Atypical,"Lipid modifying kinases","Receptor kinases","ABCB subfamily","CAMK: Calcium/calmodulin-dependent protein kinases","Inositol monophospha
tase","ABCC subfamily","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Other protein kinases","Myosin Light Chain Kinase (MLCK)
 family","1-phosphatidylinositol 4-kinase family","Other PIKK family kinases","Polo-like kinase (PLK) family","FRAP subfamily","Chromatin modifying enzymes","3.2.1.- Glycosidases","G protein-coupled r
eceptors","Eicosanoid turnover","1F. Retinoic acid-related orphans","2.1.1.43 Histone methyltransferases (HMTs)","Neuropeptide S receptor","Prostaglandin synthases"}

> <pathway_reactome>
{"Metabolism of proteins","Immune System",Disease,"Cell Cycle","Signal Transduction",Metabolism,"Neuronal System","Gene expression (Transcription)",Hemostasis,"Post-translational protein modification"
,"Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Immune system",Mitotic,"Signaling by Receptor Tyrosine Kinases","Metab
olism of lipids","Transmission across Chemical Synapses","Biological oxidations","Signaling by Rho GTPases","RNA Polymerase II Transcription","Inositol phosphate metabolism","Disorders of transmembran
e transporters","Platelet activation","signaling and aggregation",SUMOylation,"Cytosolic sensors of pathogen-associated DNA","Signaling by FGFR in disease","Signaling by Interleukins","Mitotic G2-G2/M
 phases","Signaling by Insulin receptor","Phospholipid metabolism","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization of compounds","Metabolism of steroids"
,"RHO GTPase Effectors","Generic Transcription Pathway","Synthesis of IP2",IP,"and Ins in the cytosol","ABC transporter disorders","Response to elevated platelet cytosolic Ca2+","SUMO E3 ligases SUMOy
late target proteins","STING mediated induction of host immune responses","Signaling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","G2/M Transition","Insulin receptor signall
ing cascade","PI Metabolism","Activation of NMDA receptors and postsynaptic events","Ethanol oxidation","Bile acid and bile salt metabolism","RHO GTPases activate PAKs","Transcriptional Regulation by 
TP53","Defective ABCC2 causes DJS","Platelet degranulation","SUMOylation of intracellular receptors","IRF3-mediated induction of type I IFN","FGFR1 mutant receptor activation","Interleukin receptor SH
C signaling","Centrosome maturation","IRS-mediated signalling","Synthesis of PIPs at the plasma membrane","Post NMDA receptor activation events","Synthesis of bile acids and bile salts","Regulation of
 TP53 Activity","Synthesis of PIPs at the ER membrane","Synthesis of PIPs at the Golgi membrane","Signaling by cytosolic FGFR1 fusion mutants","Loss of proteins required for interphase microtubule org
anization from the centrosome","PI3K Cascade","Activation of AMPK downstream of NMDARs","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","Regulation of TP53 Expression and Degrad
ation","Regulation of TP53 Activity through Phosphorylation","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","Developmental Biology","Nervous system development","Diseases of m
etabolism","Infectious disease","M Phase","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Diseases of carbohydrate metabolism","Leishmania infection","Mitotic G1 phase and G1/S trans
ition","Biosynthesis of specialized proresolving mediators (SPMs)","Mitotic Metaphase and Anaphase","Transcriptional regulation by RUNX3","Transcriptional regulation by RUNX1","Glycogen storage diseas
es","Leishmania parasite growth and survival","G1/S Transition","Biosynthesis of DHA-derived SPMs","Mitotic Anaphase","RUNX3 Regulates Immune Response and Cell Migration","RUNX1 regulates genes involv
ed in megakaryocyte differentiation and platelet function","Glycogen storage disease type II (GAA)","Anti-inflammatory response favouring Leishmania parasite infection","Activation of the pre-replicat
ive complex","Biosynthesis of D-series resolvins","Nuclear Envelope (NE) Reassembly","ADORA2B mediated anti-inflammatory cytokines production","Initiation of Nuclear Envelope (NE) Reformation"}

> <broad_targets>
{PI4KA,PI4KB,PIK3CA,PIK3CD,PIK3CG,PIK3R1,PLK1,PRKDC}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{wortmannin,19545-26-7,19545267,Wartmannin,"Antibiotic SL-2052","Antibiotic SL2052","KY 12420",SL-2052,SL2052,UNII-XVA4O219QW,UNIIXVA4O219QW,MFCD00133927,NSC221019,XVA4O219QW,MLS002703028,CHEMBL428496
,CHEBI:52289,"Wortmannin, 98","Pi 3-Kinase Inhibitor","Pi 3Kinase Inhibitor",wortmanin,C23H24O8,NSC627609,Wortmannin,"NSC 221019
NSC 221019",WORTMANNIN}

> <pdid>
PD004827

> <targets>
{"PI 3-K"}

> <classes>
{}

> <pubchem_cids>
{312145}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  0  0            999 V2000
   -1.7616   -9.1692    0.0000 C   0  0
   -0.7600   -8.0526    0.0000 N   0  0
    0.7077   -8.3622    0.0000 C   0  0
   -1.2256   -6.6258    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.2559   -4.6520    0.0000 C   0  0
    5.8646   -6.1001    0.0000 N   0  0
    4.3672   -6.1750    0.0000 C   0  0
    3.4207   -7.3387    0.0000 C   0  0
    1.9397   -7.1008    0.0000 C   0  0
    1.4052   -5.6993    0.0000 C   0  0
    2.3517   -4.5356    0.0000 C   0  0
    3.8327   -4.7735    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  7  1  0
 15 10  1  0
  9 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 16  1  0
 21 22  2  0
 17 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 23  1  0
 31 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28122

> <plate>
Kinase v5-1

> <well>
G13

> <supplier_cmpd_name>
GF 109203X

> <ctcr_id>
200

> <supplier_cmpd_id>
EI-246

> <smiles>
CN(C)CCCn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45

> <pd_targets>
{PRKCE,RECQL,SMN1,MAPT,FFP,FTL,PHKA1,PRKCA,PIM1,SIRT2,PRKCZ,CYP3A4,PRKACA,PRKCB,PRKCH,SIRT1,MAPK1,TSHR,CYP2C9,GSK3B,PRKCQ,PRKCG,CCND1,CDK4,CCNB1,CCNB2,CCNB3,CDK1,KMT2A,MEN1,CYP1A2,PFMRK,PRKCD,CCNE1,CC
NE2,CDK2,LEF,TP53,PRKCI,KCNH2,LMTK3}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Unclassified protein","Membrane receptor","Transcription factor","Ion channel",Kinase,Reader,Transferase,Eraser,"Cytochrome P450","Family A G 
protein-coupled receptor",Protease,"Voltage-gated ion channel","Protein Kinase","Methyl-lysine/arginine binding protein","Histone deacetylase","Cytochrome P450 family 3","Peptide receptor (family A GP
CR)","Cytochrome P450 family 2",Bromodomain,"Cytochrome P450 family 1","Metallo protease","Potassium channels","AGC protein kinase group","Tudor domain","CAMK protein kinase group","HDAC class III","C
ytochrome P450 family 3A","CMGC protein kinase group","Glycohormone receptor","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Metallo protease MAE clan","Voltage-gated potassium channel","AGC
 protein kinase PKC family","CAMK protein kinase PIM family","Cytochrome P450 3A4","AGC protein kinase PKA family","CMGC protein kinase MAPK family","Cytochrome P450 2C9","CMGC protein kinase GSK fami
ly","CMGC protein kinase CDK family","Cytochrome P450 1A1","Metallo protease M34 family","AGC protein kinase PKC eta subfamily","AGC protein kinase PKC alpha subfamily","AGC protein kinase PKC iota su
bfamily","CMGC protein kinase ERK1","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Cytochrome P450","G protein-coupled receptors","Voltage-gated ion channels","Catalytic receptors","AGC: Containi
ng PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","3.5.1.- Histone deacetylases (HDACs)","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Glycoprotein hormo
ne receptors","CYP2 family: drug metabolising subset","CYP1 family","Potassium channels","Receptor kinases","Protein kinase C (PKC) family","PIM family","Protein kinase A (PKA) family","Mitogen-activa
ted protein kinases (MAP kinases)","Glycogen synthase kinase (GSK) family","Voltage-gated potassium channels","TK: Tyrosine kinase","Eta subfamily","Delta subfamily","Iota subfamily","Alpha subfamily"
,"ERK subfamily","GSK subfamily","Receptor tyrosine kinases (RTKs)","Type XVIII RTKs: LMR family"}

> <pathway_reactome>
{"Immune System","Metabolism of RNA","Neuronal System","Vesicle-mediated transport","Signal Transduction",Disease,"Cell Cycle",Metabolism,"Gene expression (Transcription)","Muscle contraction","Innate
 Immune System","Metabolism of non-coding RNA","Transmission across Chemical Synapses","Membrane Trafficking","Signaling by GPCR","Diseases of signal transduction by growth factor receptors and second
 messengers",Mitotic,"Signaling by Nuclear Receptors","Metabolism of lipids","RNA Polymerase II Transcription","Infectious disease","Biological oxidations","Intracellular signaling by second messenger
s","Cell Cycle Checkpoints","Death Receptor Signalling","Cardiac conduction","Fcgamma receptor (FCGR) dependent phagocytosis","snRNP Assembly","Neurotransmitter receptors and postsynaptic signal trans
mission","trans-Golgi Network Vesicle Budding","GPCR downstream signalling","FLT3 signaling in disease","M Phase","ESR-mediated signaling","Biosynthesis of specialized proresolving mediators (SPMs)","
Mitotic G2-G2/M phases","Generic Transcription Pathway","Toll-like Receptor Cascades","Leishmania infection","Phase I - Functionalization of compounds","SARS-CoV Infections","DAG and IP3 signaling","U
ptake and actions of bacterial toxins","G1/S DNA Damage Checkpoints","p75 NTR receptor-mediated signalling","Phase 3 - rapid repolarisation","Role of phospholipids in phagocytosis","Activation of NMDA
 receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis","G alpha (i) signalling events","Signaling by FLT3 ITD and TKD mutants","Mitotic Metaphase and Anaphase","Extra-nuclear estrog
en signaling","Biosynthesis of DHA-derived SPMs","G2/M Transition","Mitotic Prophase","G alpha (z) signalling events","FOXO-mediated transcription","Toll Like Receptor 5 (TLR5) Cascade","Leishmania pa
rasite growth and survival","Cytochrome P450 - arranged by substrate type","SARS-CoV-1 Infection","Glutamate binding","activation of AMPA receptors and synaptic plasticity","CaM pathway","Uptake and f
unction of anthrax toxins","p53-Dependent G1/S DNA damage checkpoint","p75NTR signals via NF-kB","Post NMDA receptor activation events","Visual phototransduction","STAT5 activation downstream of FLT3 
ITD mutants","Mitotic Anaphase","Estrogen-stimulated signaling through PRKCZ","Biosynthesis of maresins","Centrosome maturation","Nuclear Envelope Breakdown","Regulation of FOXO transcriptional activi
ty by acetylation","MyD88 cascade initiated on plasma membrane","Anti-inflammatory response favouring Leishmania parasite infection",Xenobiotics,"SARS-CoV-1 Genome Replication and Transcription","Traf
ficking of AMPA receptors","Calmodulin induced events","p53-Dependent G1 DNA Damage Response","p75NTR recruits signalling complexes","Activation of AMPK downstream of NMDARs","The phototransduction ca
scade","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","Loss of proteins required for interphase microtubule organization from the centrosome","Depolymerisation of the Nuclear L
amina","MAP kinase activation","ADORA2B mediated anti-inflammatory cytokines production","CYP2E1 reactions","Replication of the SARS-CoV-1 genome","Trafficking of GluR2-containing AMPA receptors","Aro
matic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Stabilization of p53",Inactivation,"recovery and regulation of the phototransduction cascade","Initiation of Nuclear Envelope (NE) Refor
mation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{PDPK1,PIM1,PRKCI,PRKCZ}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{"bisindolylmaleimide i",133052-90-1,133052901,"GF 109203X",GF109203X,"Go 6850",GF-109203X,Go-6850,Go6850,UNII-L79H6N0V6C,UNIIL79H6N0V6C,2-(1-(3-dimethylaminopropyl)indol-3-yl)-3-(indol-3-yl)maleimide
,2(1(3dimethylaminopropyl)indol3yl)3(indol3yl)maleimide,"G&ouml; 6850",CHEMBL7463,L79H6N0V6C,2-(1-(3-Dimethylaminopropyl)indol-3-y,2(1(3Dimethylaminopropyl)indol3y,T6513,"EMD 203290",SY-GF109203X,741,
EI-246,"Bisindolylmaleimide I",203290,"GF109203X (Bisindolylmaleimide I)"}

> <pdid>
PD007247

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{2396}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 45  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -5.1962    3.0000    0.0000 O   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -7.7942   -1.5000    0.0000 O   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -5.1961   -3.0000    0.0000 C   0  0
   -6.4952   -3.7500    0.0000 C   0  0
   -7.7942   -3.0001    0.0000 O   0  0
   -6.4952   -5.2500    0.0000 C   0  0
   -5.1961   -6.0000    0.0000 C   0  0
   -5.1961   -7.5000    0.0000 O   0  0
   -3.8971   -5.2500    0.0000 C   0  0
   -2.5980   -6.0000    0.0000 C   0  0
   -2.5980   -7.5000    0.0000 O   0  0
   -1.2990   -5.2500    0.0000 C   0  0
    0.0000   -6.0000    0.0000 C   0  0
    0.0001   -7.5000    0.0000 O   0  0
    1.2991   -5.2500    0.0000 C   0  0
    1.2991   -3.7500    0.0000 C   0  0
    2.5981   -3.0000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 19 20  1  0
 20 21  1  0
 20 22  2  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  2  0
 29 30  1  0
 29 31  1  0
 31 32  1  0
 32  2  1  0
 32 33  2  0
 33  6  1  0
 33 34  1  0
 34 35  2  0
 35  9  1  0
 35 15  1  0
 34 36  1  0
 36 37  1  0
 37 25  1  0
 37 31  2  0
 36 38  2  0
 38 16  1  0
 38 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28123

> <plate>
Kinase v5-1

> <well>
G15

> <supplier_cmpd_name>
Hypericin

> <ctcr_id>
4979

> <supplier_cmpd_id>
EI-226

> <smiles>
Cc1cc(O)c2C(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6C(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c56

> <pd_targets>
{THRB,FFP,GLR1,RECQL,MAPT,POL,CYP3A4,IMPA1,ATG4B,ALDH1A1,TXNRD2,CBS,DRD3,ALOX12,HPGD,BLM,FTL,CRHR1,KMT2A,MEN1}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Other cytosolic protein","Membrane receptor","Unclassified protein","Epigenetic regulator","Nuclear receptor",Transferase,Oxidoreductase,Hydrolase,"Cytochrome P450","Fa
mily A G protein-coupled receptor",Protease,"Family B G protein-coupled receptor",Reader,"Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3","Small molecule receptor (family A GPCR)","Cy
steine protease","Peptide receptor (family B GPCR)",Bromodomain,"Nuclear hormone receptor subfamily 1 group A","Cytochrome P450 family 3A","Monoamine receptor","Cysteine protease CA clan","Corticotrop
in releasing factor receptor","Nuclear hormone receptor subfamily 1 group A member 2","Cytochrome P450 3A4","Dopamine receptor","Cysteine protease C1A family"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Cytochrome P450","Inositol phosphate turnover","Peptidases and proteinases","Hydrogen sulphide synthesis","G protein-coupled receptors","Eicosanoid turn
over","1A. Thyroid hormone receptors","CYP3 family","Inositol monophosphatase","CA: Cysteine (C) Peptidases","Dopamine receptors",Lipoxygenases,"Prostaglandin synthases","Corticotropin-releasing facto
r receptors","C54: Aut2 peptidase"}

> <pathway_reactome>
{"Metabolism of proteins","Neuronal System",Metabolism,Autophagy,"Cellular responses to external stimuli","Signal Transduction","DNA Repair","Vesicle-mediated transport",Disease,"Post-translational pr
otein modification","Transmission across Chemical Synapses","Metabolism of lipids","Inositol phosphate metabolism",Macroautophagy,"Biological oxidations","Cellular responses to stress","Metabolism of 
amino acids and derivatives","Signaling by GPCR","DNA Double-Strand Break Repair","Membrane Trafficking","Infectious disease",SUMOylation,"Neurotransmitter receptors and postsynaptic signal transmissi
on","Biosynthesis of specialized proresolving mediators (SPMs)","Synthesis of IP2",IP,"and Ins in the cytosol","Phase I - Functionalization of compounds","Detoxification of Reactive Oxygen Species","S
elenoamino acid metabolism","GPCR ligand binding","Homology Directed Repair","trans-Golgi Network Vesicle Budding","Leishmania infection","SUMO E3 ligases SUMOylate target proteins","Activation of NMD
A receptors and postsynaptic events","Biosynthesis of DHA-derived SPMs","Ethanol oxidation","Metabolism of ingested SeMet",Sec,"MeSec into H2Se","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of
 DPA-derived SPMs","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Golgi Associated Vesicle Biogenesis","Leishmania parasite growth and survival","SUMOylation of intrace
llular receptors","Post NMDA receptor activation events","Biosynthesis of maresins","Amine ligand-binding receptors","Biosynthesis of DPAn-3 SPMs","Biosynthesis of D-series resolvins","HDR through Hom
ologous Recombination (HRR)","Anti-inflammatory response favouring Leishmania parasite infection","Activation of AMPK downstream of NMDARs","Biosynthesis of maresin-like SPMs","Dopamine receptors","Bi
osynthesis of DPAn-3-derived maresins","Homologous DNA Pairing and Strand Exchange","ADORA2B mediated anti-inflammatory cytokines production","Presynaptic phase of homologous DNA pairing and strand ex
change"}

> <broad_targets>
{}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{EI-226,Hypericin}

> <pdid>
PD071021

> <targets>
{PKC,Apoptosis,"Influenza Virus"}

> <classes>
{Anti-infection,Apoptosis}

> <pubchem_cids>
{5281051}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 41  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.2559   -4.6520    0.0000 C   0  0
    5.8646   -6.1001    0.0000 N   0  0
    6.8071   -7.2647    0.0000 C   0  0
    8.2897   -7.0313    0.0000 C   0  0
    9.2338   -8.1979    0.0000 C   0  0
   10.7164   -7.9645    0.0000 S   0  0
   11.6605   -9.1312    0.0000 C   0  0
   11.1221  -10.5312    0.0000 N   0  0
   13.1423   -8.8979    0.0000 N   0  0
    4.3672   -6.1750    0.0000 C   0  0
    3.4207   -7.3387    0.0000 C   0  0
    1.9397   -7.1008    0.0000 C   0  0
    1.4052   -5.6993    0.0000 C   0  0
    2.3517   -4.5356    0.0000 C   0  0
    3.8327   -4.7735    0.0000 C   0  0
   16.9431   -3.0160    0.0000 C   0  0
   16.9431   -4.5160    0.0000 S   0  0
   16.9431   -6.0160    0.0000 O   0  0
   15.6438   -5.2655    0.0000 O   0  0
   18.2424   -5.2655    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10  5  1  0
  4 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 12 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 25 27  2  0
 20 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 18  1  0
 33 28  1  0
 34 35  1  0
 35 36  1  0
 35 37  2  0
 35 38  2  0
M  END
> <name>
UTKinase_V5

> <id>
28124

> <plate>
Kinase v5-1

> <well>
G17

> <supplier_cmpd_name>
Ro 31-8220 mesylate

> <ctcr_id>
2798

> <supplier_cmpd_id>
EI-283

> <smiles>
Cn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4cn(CCCSC(N)=N)c5ccccc45.C[S](O)(=O)=O

> <pd_targets>
{PRKCA,HST2,HIPK1,TP53,SIRT1,SIRT2,RPS6KB1,PIM1,PRKCB,TBK1,RPS6KA3,GSK3B,MAPT,FTL,RPS6KA2,KMT2A,MEN1,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,MDH,SIRT3,RORC,ALD,PRKACA,CTRB1,FFP,MAP4K1,VR
K2,MAP3K8,VRK1,MAPK1,RECQL,HSD17B10,CYP3A4,TSHR,ALOX15,LEF,RPS6KA5}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator","Other cytosolic protein","Unclassified protein","Membrane receptor",Kinase,Eraser,Reader,Oxidoreductase,"Nuclear receptor",Transferase,Protease,"
Cytochrome P450","Family A G protein-coupled receptor","Protein Kinase","Histone deacetylase",Bromodomain,"Nuclear hormone receptor subfamily 1","Serine protease","Cysteine protease","Cytochrome P450 
family 3","Peptide receptor (family A GPCR)","Metallo protease","AGC protein kinase group","CMGC protein kinase group","HDAC class III","CAMK protein kinase group","Other protein kinase group","Nuclea
r hormone receptor subfamily 1 group F","STE protein kinase group","CK1 protein kinase group","Serine protease PA clan","Cysteine protease CA clan","Cytochrome P450 family 3A","Glycohormone receptor",
"Metallo protease MAE clan","AGC protein kinase PKC family","CMGC protein kinase DYRK family","AGC protein kinase RSK family","CAMK protein kinase PIM family","Other protein kinase IKK family","CMGC p
rotein kinase GSK family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKA family","STE protein kinase STE20 family","STE protein kinase STE11 family","CK1 protein kinas
e VRK family","Serine protease S1A subfamily","CMGC protein kinase MAPK family","Cysteine protease C1A family","Cytochrome P450 3A4","Metallo protease M34 family","AGC protein kinase PKC alpha subfami
ly","CMGC protein kinase HIPK subfamily","AGC protein kinase p70 subfamily","AGC protein kinase RSK subfamily","STE protein kinase KHS subfamily","CMGC protein kinase ERK1","AGC protein kinase MSK sub
family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Catalytic receptors","Nuclear hormone receptors","Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","AGC: Co
ntaining PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","3.5.1.- Histone deacetylases (HDACs)","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","1F. Ret
inoic acid-related orphans","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","CYP3 family","Glycoprotein hormone receptors",Lipoxygenases,"Protein kinase C (
PKC) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","RSK family","PIM family","Other protein kinases","Glycogen synthase kinase (GSK) family","Protein kinase A 
(PKA) family","STE20 family","Vaccina related kinase (VRK) family","STE-unique family","Mitogen-activated protein kinases (MAP kinases)","Delta subfamily","HIPK subfamily","p70 subfamily","Alpha subfa
mily","IKK family","RSK subfamily","GSK subfamily","KHS subfamily","ERK subfamily","MSK subfamily"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Cell Cycle",Disease,"Immune System","Neuronal System","Vesicle-mediated transport",Metabolism,"Signaling by GPCR","RNA Polymerase II Transcrip
tion","Cell Cycle Checkpoints",Mitotic,"MTOR signalling","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System","Infectious disease","Transmission ac
ross Chemical Synapses","Membrane Trafficking","Cytokine Signaling in Immune system","Metabolism of vitamins and cofactors","Metabolism of amino acids and derivatives","Metabolism of lipids","GPCR dow
nstream signalling","Generic Transcription Pathway","G1/S DNA Damage Checkpoints","M Phase","mTORC1-mediated signalling","FLT3 signaling in disease","Toll-like Receptor Cascades","SARS-CoV Infections"
,"Neurotransmitter receptors and postsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","Signaling by Interleukins","Metabolism of water-soluble vitamins and 
cofactors","Branched-chain amino acid catabolism","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","Uptake and actions of bacterial toxins","G alpha (i) signalling ev
ents","Transcriptional Regulation by TP53","p53-Dependent G1/S DNA damage checkpoint","FOXO-mediated transcription","Mitotic Metaphase and Anaphase","Signaling by FLT3 ITD and TKD mutants","Mitotic Pr
ophase","Toll Like Receptor 4 (TLR4) Cascade","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-1 Infection","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis",
"Transcriptional regulation by RUNX3","G2/M Transition","Interleukin-1 family signaling","Cobalamin (Cbl","vitamin B12) transport and metabolism","Biosynthesis of DHA-derived SPMs","Leishmania parasit
e growth and survival","Biosynthesis of DPA-derived SPMs","Uptake and function of anthrax toxins","Visual phototransduction","Regulation of TP53 Activity","p53-Dependent G1 DNA Damage Response","Regul
ation of FOXO transcriptional activity by acetylation","Mitotic Anaphase","STAT5 activation downstream of FLT3 ITD mutants","Nuclear Envelope Breakdown","MyD88-independent TLR4 cascade","MyD88 cascade
 initiated on plasma membrane","SARS-CoV-1 Genome Replication and Transcription","Post NMDA receptor activation events","FOXO-mediated transcription of oxidative stress","metabolic and neuronal genes"
,"RUNX3 Regulates Immune Response and Cell Migration","Centrosome maturation","Interleukin-1 signaling","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection",
"Biosynthesis of DPAn-3 SPMs","The phototransduction cascade","Regulation of TP53 Activity through Phosphorylation","Stabilization of p53","Nuclear Envelope (NE) Reassembly","Depolymerisation of the N
uclear Lamina","TRIF(TICAM1)-mediated TLR4 signaling","MAP kinase activation","Replication of the SARS-CoV-1 genome","Activation of AMPK downstream of NMDARs","Loss of proteins required for interphase
 microtubule organization from the centrosome","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammatory cytokines production","Biosynthesis 
of DPAn-3-derived protectins and resolvins",Inactivation,"recovery and regulation of the phototransduction cascade","Autodegradation of the E3 ubiquitin ligase COP1","Initiation of Nuclear Envelope (N
E) Reformation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","MAPK targets/ Nuclear events mediated by MAP kinases","Loss of Nlp from mitotic centrosomes","CREB phosphorylation","ERK/MAPK ta
rgets","ERKs are inactivated"}

> <broad_targets>
{AKT1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,ROCK1,RPS6KB1,SIRT1}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{"Ro 31-8220 mesylate","Ro 318220 mesylate",138489-18-6,138489186,"Bisindolylmaleimide IX mesylate","Ro 31-8220 (mesylate)","Ro 318220 (mesylate)","RO31-8220 mesylate","RO318220 mesylate","Bisindolylm
aleimide IX, Methanesulfonate",CHEMBL1591531,"InSolution&trade; Ro-31-8220","InSolution&trade; Ro318220",BMK1-D9,BMK1D9,"RO31-8220 methanesulfonate","RO318220 methanesulfonate",Ro?31-8220,Ro?318220,T6
643,"EMD 557520",2002,EI-283,"Ro 31-8220 Mesylate",557520}

> <pdid>
PD038906

> <targets>
{"Broad Spectrum Inhibitor",Ro-31-8220,PKC}

> <classes>
{}

> <pubchem_cids>
{11628205}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 20  0  0  1  0            999 V2000
    0.0007    0.0004    0.0000 C   0  0
    1.3000    0.7500    0.0000 C   0  0
    2.6000    0.0000    0.0000 C   0  0
    3.9000    0.7500    0.0000 C   0  0
    5.2000    0.0000    0.0000 C   0  0
    6.5000    0.7500    0.0000 C   0  0
    7.7999    0.0000    0.0000 C   0  0
    9.0999    0.7500    0.0000 C   0  0
   10.3999    0.0000    0.0000 C   0  0
   11.6999    0.7500    0.0000 C   0  0
   12.9999    0.0000    0.0000 C   0  0
   14.2999    0.7500    0.0000 C   0  0
   15.5999    0.0000    0.0000 C   0  0
   16.8999    0.7500    0.0000 C   0  0
   18.1999    0.0000    0.0000 C   0  0
   19.4998    0.7500    0.0000 C   0  0  1  0  0  0
   19.4998    2.2500    0.0000 O   0  0
   20.7998    0.0000    0.0000 C   0  0  1  0  0  0
   20.7998   -1.5000    0.0000 N   0  0
   22.0998    0.7500    0.0000 C   0  0
   23.3991    0.0004    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  1
 16 18  1  0
 18 19  1  6
 18 20  1  0
 20 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28125

> <plate>
Kinase v5-1

> <well>
G19

> <supplier_cmpd_name>
D-erythro-Sphingosine

> <ctcr_id>
7693

> <supplier_cmpd_id>
EI-155

> <smiles>
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO

> <pd_targets>
{TRPM3,SPHK1,GLA,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCQ,PRKCZ,BLM,UBE2N,FTL,NFO,FFP,KMT2A,MEN1,PRKACA,SPHK2,MAPT,GMNN,LMNA,CCR6,TRPM7,POLB,CETP,THRB,MAPK1,SKA}

> <pathway_gtopdb>
{"Unclassified protein",Enzyme,"Epigenetic regulator","Other cytosolic protein","Other nuclear protein","Membrane receptor","Ion channel","Transcription factor",Hydrolase,Kinase,Aminoacyltransferase,T
ransferase,Reader,Protease,"Family A G protein-coupled receptor","Voltage-gated ion channel","Other ion channel","Nuclear receptor","Protein Kinase",Bromodomain,"Cysteine protease","Peptide receptor (
family A GPCR)","Transient receptor potential channel","Pore-forming toxins (proteins and peptides)","Nuclear hormone receptor subfamily 1","AGC protein kinase group","Cysteine protease CA clan","Chem
okine receptor","Nuclear hormone receptor subfamily 1 group A","CMGC protein kinase group","AGC protein kinase PKC family","AGC protein kinase PKA family","Cysteine protease C1A family","CC chemokine 
receptor","Nuclear hormone receptor subfamily 1 group A member 2","CMGC protein kinase MAPK family","AGC protein kinase PKC alpha subfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{"Ion channels",Enzymes,Receptors,"Voltage-gated ion channels","Sphingosine 1-phosphate turnover","Kinases (EC 2.7.x.x)","G protein-coupled receptors","Nuclear hormone receptors","Transient Receptor P
otential channels","Sphingosine kinase","AGC: Containing PKA",PKG,"PKC families","Chemokine receptors",Atypical,"1A. Thyroid hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Protein
 kinase A (PKA) family","Alpha kinase family","Mitogen-activated protein kinases (MAP kinases)","ChaK subfamily","ERK subfamily"}

> <pathway_reactome>
{"Transport of small molecules","Signal Transduction",Metabolism,"DNA Repair","Immune System","Vesicle-mediated transport","Cell Cycle","Neuronal System","Metabolism of proteins","Ion channel transpor
t","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","DNA Double-Strand Break Repair","Innate Immune System","Membrane Trafficking",Mitotic,"Transmission across Chemical Synapses","Signa
ling by GPCR","Base Excision Repair","Signaling by Nuclear Receptors","Post-translational protein modification","Stimuli-sensing channels","Signaling by VEGF","Sphingolipid metabolism","Homology Direc
ted Repair","Toll-like Receptor Cascades","trans-Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","Neurotransmitter receptors and postsynaptic signal transmission","Mitotic G1 phase and G1/S tr
ansition","M Phase","GPCR ligand binding","Resolution of Abasic Sites (AP sites)","NR1H2 and NR1H3-mediated signaling",SUMOylation,"TRP channels","VEGFA-VEGFR2 Pathway","Glycosphingolipid metabolism",
"HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Toll Like Receptor 4 (TLR4) Cascade","Golgi Associated Vesicle Biogenesis","G2/M Transition","Sphingolipid de novo biosyn
thesis","Activation of NMDA receptors and postsynaptic events","G1/S Transition","Mitotic Metaphase and Anaphase","Class A/1 (Rhodopsin-like receptors)","Resolution of AP sites via the multiple-nucleo
tide patch replacement pathway","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","SUMO E3 ligases SUMOylate target proteins","Toll Like Receptor 5 (TLR5) Cascade","V
EGFR2 mediated cell proliferation","HDR through Homologous Recombination (HRR)","MyD88-independent TLR4 cascade","Centrosome maturation","Post NMDA receptor activation events","Activation of the pre-r
eplicative complex","Mitotic Anaphase","Peptide ligand-binding receptors","PCNA-Dependent Long Patch Base Excision Repair","SUMOylation of intracellular receptors","MyD88 cascade initiated on plasma m
embrane","Homologous DNA Pairing and Strand Exchange","TRIF(TICAM1)-mediated TLR4 signaling","Loss of proteins required for interphase microtubule organization from the centrosome","Activation of AMPK
 downstream of NMDARs","Nuclear Envelope (NE) Reassembly","Chemokine receptors bind chemokines","MAP kinase activation","Presynaptic phase of homologous DNA pairing and strand exchange","IKK complex r
ecruitment mediated by RIP1","Loss of Nlp from mitotic centrosomes","Initiation of Nuclear Envelope (NE) Reformation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs ar
e inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{c18-erythro-sphingenine,c18erythrosphingenine,"4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))-","4Octadecene1,3diol, 2amino, (R(R*,S*(E)))","(2S,3R)-2-Amino-4-octadecene-1,3-diol","(2S,3R)2Amino4oc
tadecene1,3diol",MLS-0412588.0001,MLS0412588.0001,sphingosin,(4E)-sphing-4-enine,(4E)sphing4enine,SMR000857107,CHEMBL67166,"D-erythro-Sphingosine, 99+, synthetical","DerythroSphingosine, 99+, syntheti
cal",(-)-D-erythr,()Derythr,EI-155,D-erythro-Sphingosine}

> <pdid>
PD019972

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{5280335}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 21  0  0  0  0            999 V2000
    2.6030   -2.9977    0.0000 O   0  0
    2.6003   -1.4977    0.0000 C   0  0
    3.8983   -0.7459    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -0.0080    6.0003    0.0000 C   0  0
   -0.0080    7.5003    0.0000 C   0  0
    1.2910    8.2504    0.0000 O   0  0
   -1.3071    8.2503    0.0000 C   0  0
   -2.6061    7.5003    0.0000 C   0  0
   -2.6061    6.0003    0.0000 C   0  0
   -3.9051    5.2503    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  2  0
 15  9  1  0
 15 16  1  0
  6 17  2  0
 17 18  1  0
 18 19  2  0
 19  4  1  0
 19 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28128

> <plate>
Kinase v5-1

> <well>
I05

> <supplier_cmpd_name>
2-Hydroxy-5-(2,5-dihydroxybenzylamino)benzoic acid

> <ctcr_id>
377

> <supplier_cmpd_id>
EI-232

> <smiles>
OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O

> <pd_targets>
{MAPT,LCK,EGFR,TDP1,ALDH1A1,CAMKK2,RGS12,FFP,NOX4}

> <pathway_gtopdb>
{"Other cytosolic protein",Enzyme,Kinase,Hydrolase,Oxidoreductase,Transferase,"Protein Kinase","TK protein kinase group","Other protein kinase group","Tyrosine protein kinase Src family","Tyrosine pro
tein kinase EGFR family","Other protein kinase CAMKK family","Other protein kinase Meta subfamily"}

> <pathway_chembl>
{Receptors,"Other protein targets",Enzymes,"Catalytic receptors","Regulators of G protein Signaling (RGS) proteins","NADPH oxidases","Receptor kinases","R12 family","TK: Tyrosine kinase","Other protei
n kinases","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","CAMKK family","Src family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Meta subfamily"}

> <pathway_reactome>
{"Neuronal System",Disease,"Signal Transduction","DNA Repair",Metabolism,"Transmission across Chemical Synapses","Infectious disease","Signaling by GPCR","DNA Double-Strand Break Repair","Biological o
xidations","Diseases of signal transduction by growth factor receptors and second messengers","Neurotransmitter receptors and postsynaptic signal transmission","HIV Infection","GPCR downstream signall
ing","Nonhomologous End-Joining (NHEJ)","Phase I - Functionalization of compounds","FLT3 signaling in disease","Activation of NMDA receptors and postsynaptic events","Host Interactions of HIV factors"
,"G alpha (q) signalling events","Ethanol oxidation","G alpha (i) signalling events","Signaling by FLT3 ITD and TKD mutants","Post NMDA receptor activation events","The role of Nef in HIV-1 replicatio
n and disease pathogenesis","Gastrin-CREB signalling pathway via PKC and MAPK","STAT5 activation downstream of FLT3 ITD mutants","Activation of AMPK downstream of NMDARs","Nef-mediates down modulation
 of cell surface receptors by recruiting them to clathrin adapters","EGFR Transactivation by Gastrin","Nef Mediated CD4 Down-regulation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"lavendustin c",125697-93-0,125697930,HDBA,"Compound 5",UNII-HJM06BIW5M,UNIIHJM06BIW5M,"5-(2,5-Dihydroxybenzylamino)-2-hydroxybenzoic acid","5(2,5Dihydroxybenzylamino)2hydroxybenzoic acid","5-((2,5-D
ihydroxybenzyl)amino)-2-hydroxybenzoic acid","5((2,5Dihydroxybenzyl)amino)2hydroxybenzoic acid",HJM06BIW5M,CHEMBL319620,5-((2,5((2,5-dihydroxyphenyl)methylamino)-2-hydroxyb,5dihydroxyphenyl)methylamin
o)2hydroxyb,EI-232,"2-Hydroxy-5-(2,5-dihydroxybenzylamino)benzoic acid"}

> <pdid>
PD020212

> <targets>
{EGFRK,"CaMK II"}

> <classes>
{}

> <pubchem_cids>
{3896}

$$$$
UTKinase_V5
  SciTegic11012413002D

 51 57  0  0  0  0            999 V2000
   11.6839   -5.2737    0.0000 C   0  0
   11.6905   -3.7738    0.0000 N   0  0
   10.3938   -3.0180    0.0000 C   0  0
    9.0905   -3.7623    0.0000 C   0  0
    9.0825   -5.2631    0.0000 C   0  0
   10.3760   -6.0227    0.0000 C   0  0
   10.3648   -7.5227    0.0000 C   0  0
    9.0603   -8.2631    0.0000 C   0  0
    9.0461   -9.7639    0.0000 O   0  0
    7.7398  -10.5028    0.0000 S   0  0
    6.4477   -9.7410    0.0000 O   0  0
    7.7533   -9.0029    0.0000 O   0  0
    7.7256  -12.0036    0.0000 C   0  0
    9.0175  -12.7658    0.0000 C   0  0
    9.0033  -14.2657    0.0000 C   0  0
    7.6973  -15.0034    0.0000 C   0  0
    6.4054  -14.2412    0.0000 C   0  0
    5.0993  -14.9789    0.0000 C   0  0
    3.8074  -14.2166    0.0000 N   0  0
    3.8216  -12.7167    0.0000 C   0  0
    5.1277  -11.9790    0.0000 C   0  0
    6.4195  -12.7413    0.0000 C   0  0
    7.7668   -7.5034    0.0000 C   0  0
    7.7779   -6.0035    0.0000 C   0  0
   10.3974   -1.5172    0.0000 C   0  0
   11.6984   -0.7707    0.0000 O   0  0
    9.0998   -0.7629    0.0000 N   0  0
    9.1012    0.7371    0.0000 C   0  0
    7.8028    1.4883    0.0000 C   0  0
    6.5031    0.7396    0.0000 N   0  0
    6.5017   -0.7604    0.0000 C   0  0
    7.8000   -1.5117    0.0000 C   0  0
    5.2041    1.4912    0.0000 C   0  0
    5.2031    2.9912    0.0000 C   0  0
    3.9036    3.7404    0.0000 C   0  0
    2.6050    2.9896    0.0000 C   0  0
    2.6060    1.4896    0.0000 C   0  0
    3.9055    0.7404    0.0000 C   0  0
   12.9938   -3.0295    0.0000 S   0  0
   13.0004   -1.5295    0.0000 O   0  0
   11.6982   -2.2736    0.0000 O   0  0
   14.2905   -3.7852    0.0000 C   0  0
   14.2843   -5.2852    0.0000 C   0  0
   15.5803   -6.0405    0.0000 C   0  0
   16.8824   -5.2958    0.0000 C   0  0
   16.8885   -3.7958    0.0000 C   0  0
   18.1906   -3.0511    0.0000 C   0  0
   18.1967   -1.5512    0.0000 N   0  0
   16.9008   -0.7959    0.0000 C   0  0
   15.5987   -1.5405    0.0000 C   0  0
   15.5925   -3.0405    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  2  0
 10 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 13  1  0
 22 17  1  0
  8 23  1  0
 23 24  2  0
 24  5  1  0
  3 25  1  0
 25 26  2  0
 25 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 27  1  0
 30 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 37  1  0
 37 38  2  0
 38 33  1  0
  2 39  1  0
 39 40  2  0
 39 41  2  0
 39 42  1  0
 42 43  2  0
 43 44  1  0
 44 45  2  0
 45 46  1  0
 46 47  2  0
 47 48  1  0
 48 49  2  0
 49 50  1  0
 50 51  2  0
 51 42  1  0
 51 46  1  0
M  END
> <name>
UTKinase_V5

> <id>
28129

> <plate>
Kinase v5-1

> <well>
I07

> <supplier_cmpd_name>
KN-62

> <ctcr_id>
1792

> <supplier_cmpd_id>
EI-230

> <smiles>
CN(C(Cc1ccc(O[S](=O)(=O)c2cccc3cnccc23)cc1)C(=O)N4CCN(CC4)c5ccccc5)[S](=O)(=O)c6cccc7cnccc67

> <pd_targets>
{AMPC,P2X7,RORC,CAMK2D,CAMK2A,P2RX4,P2RX7,HTT,LMNA,MAPT,NS1,FTL,ALDH1A1}

> <pathway_gtopdb>
{Enzyme,"Ion channel","Transcription factor","Unclassified protein","Other nuclear protein","Other cytosolic protein",Hydrolase,"Ligand-gated ion channel","Nuclear receptor",Kinase,Protease,Oxidoreduc
tase,"P2X receptor","Nuclear hormone receptor subfamily 1","Protein Kinase","Cysteine protease","Nuclear hormone receptor subfamily 1 group F","CAMK protein kinase group","Cysteine protease CA clan","
Nuclear hormone receptor subfamily 1 group F member 3","CAMK protein kinase CAMK2 family","Cysteine protease C1A family"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Ligand-gated ion channels","1F. Retinoic acid-related orphans","CAMK: Calcium/calmodulin-dependent protein kinases
","P2X receptors","CAMK2 family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Neuronal System",Disease,"Cell Cycle","Vesicle-mediated transport",Metabolism,"RNA Polymerase II Transcription","Transmission across Chemical Synapses","Infectious 
disease",Mitotic,"Membrane Trafficking","Biological oxidations","Generic Transcription Pathway","Neurotransmitter receptors and postsynaptic signal transmission","Leishmania infection","M Phase","tran
s-Golgi Network Vesicle Budding","Phase I - Functionalization of compounds","Transcriptional regulation by RUNX3","Activation of NMDA receptors and postsynaptic events","Cell recruitment (pro-inflamma
tory response)","Transcriptional Regulation by MECP2","Mitotic Metaphase and Anaphase","Golgi Associated Vesicle Biogenesis","Ethanol oxidation","RUNX3 Regulates Immune Response and Cell Migration","P
ost NMDA receptor activation events","Purinergic signaling in leishmaniasis infection","Regulation of MECP2 expression and activity","Mitotic Anaphase","CREB1 phosphorylation through NMDA receptor-med
iated activation of RAS signaling","Nuclear Envelope (NE) Reassembly","Activation of AMPK downstream of NMDARs","Ras activation upon Ca2+ influx through NMDA receptor","Initiation of Nuclear Envelope 
(NE) Reformation"}

> <broad_targets>
{AKT1,CAMK2A,CHEK1,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,P2RX7,PRKCA,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"calcium/calmodulin dependent protein kinase inhibitor","purinergic receptor antagonist"}

> <synonyms>
{N6,CHEMBL130321,BiomolKI_000040,BiomolKI000040,BiomolKI-000040,"BiomolKI 000040",ACMC-20c5c5,ACMC20c5c5,BiomolKI2_000048,BiomolKI2000048,BiomolKI2-000048,"BiomolKI2 000048",BMK1-E4,BMK1E4,BSPBio_0011
81,BSPBio001181,BSPBio-001181,"BSPBio 001181",KBioGR_000521,KBioGR000521,KBioGR-000521,"KBioGR 000521",KBioSS_000521,KBioSS000521,KBioSS-000521,"KBioSS 000521",SCHEMBL1982403,CHEBI:91888,KBio2_000521,
KBio2000521,KBio2-000521,"KBio2 000521",KBio2_003089,KBio2003089,KBio2-003089,"KBio2 003089",KBio2_005657,KBio2005657,KBio2-005657,"KBio2 005657",KBio3_000941,KBio3000941,KBio3-000941,"KBio3 000941",K
Bio3_000942,KBio3000942,KBio3-000942,"KBio3 000942",BRD7136,DTXSID70925812,Bio2_000421,Bio2000421,Bio2-000421,"Bio2 000421",Bio2_000901,Bio2000901,Bio2-000901,"Bio2 000901",HM,T2694,SY-KN-62,EI-230,KN
-62}

> <pdid>
PD010322

> <targets>
{"CaMK II","CaM Kinase"}

> <classes>
{}

> <pubchem_cids>
{3838}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 36  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 N   0  0
   -1.3018    3.7547    0.0000 C   0  0
   -1.3044    5.2556    0.0000 C   0  0
   -0.0072    6.0086    0.0000 O   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -5.1971    2.9990    0.0000 C   0  0
   -6.4977    3.7464    0.0000 C   0  0
   -6.5007    5.2464    0.0000 C   0  0
   -5.2032    5.9990    0.0000 C   0  0
   -3.9027    5.2517    0.0000 C   0  0
   -2.6060    6.0074    0.0000 C   0  0
   -2.6113    7.5082    0.0000 N   0  0
   -3.9131    8.2533    0.0000 C   0  0
   -1.3146    8.2640    0.0000 C   0  0
   -1.3199    9.7648    0.0000 C   0  0
   -0.0232   10.5206    0.0000 C   0  0
   -0.0285   12.0214    0.0000 C   0  0
    1.2664   12.7787    0.0000 C   0  0
    1.2581   14.2787    0.0000 C   0  0
   -0.0451   15.0215    0.0000 C   0  0
   -0.0534   16.5215    0.0000 Cl  0  0
   -1.3400   14.2643    0.0000 C   0  0
   -1.3317   12.7643    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  6  9  1  0
  9 10  2  0
  9 11  2  0
  9 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 12 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 31 33  1  0
 33 34  2  0
 34 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28130

> <plate>
Kinase v5-1

> <well>
I09

> <supplier_cmpd_name>
KN-93

> <ctcr_id>
7700

> <supplier_cmpd_id>
EI-268

> <smiles>
COc1ccc(cc1)[S](=O)(=O)N(CCO)c2ccccc2CN(C)C\C=C\c3ccc(Cl)cc3

> <pd_targets>
{CAMK2A,CAMK2B,CAMK2D,CAMK2G,MYLK,RORC}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,"Nuclear receptor",Protease,"Protein Kinase","Nuclear hormone receptor subfamily 1","Cysteine protease","CAMK protein kinase group","Nuclear hormone receptor subf
amily 1 group F","Cysteine protease CA clan","CAMK protein kinase CAMK2 family","CAMK protein kinase MLCK family","Nuclear hormone receptor subfamily 1 group F member 3","Cysteine protease C1A family"
}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Nuclear hormone receptors","CAMK: Calcium/calmodulin-dependent protein kinases","1F. Retinoic acid-related orphans","CAMK2 family","Myosin Light Chain Kinase
 (MLCK) family"}

> <pathway_reactome>
{"Neuronal System","Signal Transduction","Gene expression (Transcription)","Transmission across Chemical Synapses","Signaling by Rho GTPases","RNA Polymerase II Transcription","Neurotransmitter recept
ors and postsynaptic signal transmission","RHO GTPase Effectors","Generic Transcription Pathway","Activation of NMDA receptors and postsynaptic events","RHO GTPases activate PAKs","Transcriptional reg
ulation by RUNX3","Post NMDA receptor activation events","RUNX3 Regulates Immune Response and Cell Migration","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Ras ac
tivation upon Ca2+ influx through NMDA receptor"}

> <broad_targets>
{CAMK2A}

> <broad_moa>
{"calcium/calmodulin dependent protein kinase inhibitor"}

> <synonyms>
{N9,"N 9",kn-93,kn93,"kn 93",139298-40-1,139298401,"139298 40 1","KN 93",KN93,Methoxybenzene-sulfonamide,Methoxybenzenesulfonamide,"Methoxybenzene sulfonamide","KN-93 free base","KN93 free base","KN 9
3 free base","139298-40-1 (free base)","139298401 (free base)","EMD 422708",EI-268,422708,KN-93}

> <pdid>
PD003273

> <targets>
{CaMK}

> <classes>
{}

> <pubchem_cids>
{5312122}

$$$$
UTKinase_V5
  SciTegic11012413002D

 10 11  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9  5  1  0
  9 10  2  0
 10  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28133

> <plate>
Kinase v5-1

> <well>
I15

> <supplier_cmpd_name>
2-Aminopurine

> <ctcr_id>
665

> <supplier_cmpd_id>
CC-100

> <smiles>
Nc1ncc2[nH]cnc2n1

> <pd_targets>
{ALDH1A1,AMPC}

> <pathway_gtopdb>
{Enzyme,Oxidoreductase,Hydrolase}

> <pathway_chembl>
{}

> <pathway_reactome>
{Metabolism,"Biological oxidations","Phase I - Functionalization of compounds","Ethanol oxidation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{AMINOPURIN,2-aminopurine,2aminopurine,7H-purin-2-amine,7Hpurin2amine,452-06-2,452062,1H-PURIN-2-AMINE,1HPURIN2AMINE,9H-Purin-2-amine,9HPurin2amine,"Purine, 2-amino-","Purine, 2amino",Aminopurine,"SQ 
22451",191236-69-8,191236698,"2-amino purine","2amino purine",2'-amino-purine,2'aminopurine,UNII-O14B3U97FW,UNIIO14B3U97FW,7H-Purin-2-ylamine,7HPurin2ylamine,9H-Purin-2-ylamine,9HPurin2ylamine,"SQ 22,
451",CHEMBL388594,O,CC-100,2-Aminopurine}

> <pdid>
PD044966

> <targets>
{"p58 PITSLRE beta1"}

> <classes>
{}

> <pubchem_cids>
{9955}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 26  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8933    3.7570    0.0000 C   0  0
    3.8933    5.2571    0.0000 C   0  0
    5.1924    6.0071    0.0000 C   0  0
    6.4914    5.2571    0.0000 C   0  0
    6.4915    3.7571    0.0000 C   0  0
    5.1925    3.0071    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4983    0.7413    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
  8 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 18 23  1  0
 23 24  2  0
 24  4  1  0
 24  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28134

> <plate>
Kinase v5-1

> <well>
I17

> <supplier_cmpd_name>
N9-isopropyl-olomoucine

> <ctcr_id>
5865

> <supplier_cmpd_id>
CC-202

> <smiles>
CC(C)n1cnc2c(NCc3ccccc3)nc(NCCO)nc12

> <pd_targets>
{HIPK4,DYRK1A,SRPK1,CDK5,CLK2,CLK4,CSNK1D,CDK1,CDK2,RORC}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,"Nuclear receptor","Protein Kinase","Nuclear hormone receptor subfamily 1","CMGC protein kinase group","CK1 protein kinase group","Nuclear hormone receptor subfam
ily 1 group F","CMGC protein kinase DYRK family","CMGC protein kinase SRPK family","CMGC protein kinase CDK family","CMGC protein kinase CLK family","CK1 protein kinase CK1 family","Nuclear hormone re
ceptor subfamily 1 group F member 3","CMGC protein kinase HIPK subfamily","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Nuclear hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","1F. Retinoic acid-related orphans","Dual-specificity tyros
ine-(Y)-phosphorylation regulated kinase (DYRK) family","SRPK family","Cyclin-dependent kinase (CDK) family","CLK family","Casein kinase 1 (CK1) family","HIPK subfamily","Dyrk1 subfamily","CDK5 subfam
ily","CDK1 subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Mitotic,"RNA Polymerase II Transcription","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Mitotic G2-G2/M phases","Regulation of
 mitotic cell cycle","G0 and Early G1","Transcriptional Regulation by TP53","G2/M Transition","APC/C-mediated degradation of cell cycle proteins","Transcriptional regulation by RUNX3","Regulation of T
P53 Activity","Centrosome maturation","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","RUNX3 Regulates Immune Response and Cell Migration","Regulation of TP53 Activity t
hrough Phosphorylation","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Expression an
d Degradation","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Regulation of TP53 Degradation","Cdc20:
Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{9ISOPROPYLOLOMOUCIN,"9 ISOPROPYL OLOMOUCIN",N9-ISOPROPYL-OLOMOUCINE,N9ISOPROPYLOLOMOUCINE,"N9 ISOPROPYL OLOMOUCINE",158982-15-1,158982151,"158982 15 1",9-Isopropylolomoucine,9Isopropylolomoucine,"9 I
sopropylolomoucine",N9-Isopropyl,N9Isopropyl,ALX-270-397-M005,CC-202,N9-isopropylolomoucine,N9-isopropyl-olomoucine}

> <pdid>
PD003350

> <targets>
{CDK}

> <classes>
{}

> <pubchem_cids>
{6610355}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8933    3.7570    0.0000 C   0  0
    3.8933    5.2571    0.0000 C   0  0
    5.1924    6.0071    0.0000 C   0  0
    6.4914    5.2571    0.0000 C   0  0
    6.4915    3.7571    0.0000 C   0  0
    5.1925    3.0071    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4983    0.7413    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
  6 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 16 21  1  0
 21 22  2  0
 22  2  1  0
 22  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28135

> <plate>
Kinase v5-1

> <well>
I19

> <supplier_cmpd_name>
Olomoucine

> <ctcr_id>
510

> <supplier_cmpd_id>
CC-200

> <smiles>
Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12

> <pd_targets>
{MAPK3,CDK2,CCNB1,CDK1,CCNE1,CDK5,CDK5R1,GAA,MAPT,CYP3A4,MAPK1,CCNE2,SMN1,ALOX15,CYP1A2,NFKB1,CYP2D6,CCNB2,CCNB3,CCNA1,CCNA2,KDM4E,TDP1,LEF,ALDH1A1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator",Kinase,Hydrolase,"Cytochrome P450",Reader,Oxidoreductase,Eraser,Protease,"Protein Kinase","Cytochrome P450 family 3","Methyl-lysine/arginine bi
nding protein","Cytochrome P450 family 1","Cytochrome P450 family 2","Lysine demethylase","Metallo protease","CMGC protein kinase group","Cytochrome P450 family 3A","Tudor domain","Cytochrome P450 fam
ily 1A","Cytochrome P450 family 2D","Jumonji domain-containing","Metallo protease MAE clan","CMGC protein kinase MAPK family","CMGC protein kinase CDK family","Cytochrome P450 3A4","Cytochrome P450 1A
1","Cytochrome P450 2D6","Metallo protease M34 family","CMGC protein kinase ERK1","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","3.2.1.- Glycosidases","Cytochrome P450","Eicosanoid turnover","Chromatin modifying enzymes","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP3 family",Lipoxygenases
,"CYP1 family","CYP2 family: drug metabolising subset","1.14.11.- Histone demethylases","Mitogen-activated protein kinases (MAP kinases)","Cyclin-dependent kinase (CDK) family","ERK subfamily","CDK1 s
ubfamily","CDK5 subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)","Cell Cycle",Disease,"Neuronal System",Metabolism,"Metabolism of RNA","DNA Repair","Innate Immune System","RNA Polymerase II Transcription",Mitotic,"
Diseases of metabolism","Transmission across Chemical Synapses","Metabolism of lipids","Metabolism of non-coding RNA","Biological oxidations","Cytokine Signaling in Immune system","DNA Double-Strand B
reak Repair","Infectious disease","Toll-like Receptor Cascades","Generic Transcription Pathway","Regulation of mitotic cell cycle","Diseases of carbohydrate metabolism","Neurotransmitter receptors and
 postsynaptic signal transmission","Biosynthesis of specialized proresolving mediators (SPMs)","snRNP Assembly","Phase I - Functionalization of compounds","Signaling by Interleukins","Nonhomologous En
d-Joining (NHEJ)","Uptake and actions of bacterial toxins","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional Regulation by TP53","APC/C-mediated degradation of cell cycle proteins","Glycogen stor
age diseases","Activation of NMDA receptors and postsynaptic events","Biosynthesis of DHA-derived SPMs","Biosynthesis of DPA-derived SPMs","Cytochrome P450 - arranged by substrate type","Interleukin-1
 family signaling","Uptake and function of anthrax toxins","Ethanol oxidation","MyD88 cascade initiated on plasma membrane","Regulation of TP53 Activity","Activation of APC/C and APC/C:Cdc20 mediated 
degradation of mitotic proteins","Glycogen storage disease type II (GAA)","Post NMDA receptor activation events","Biosynthesis of maresins","Biosynthesis of DPAn-3 SPMs",Xenobiotics,"Interleukin-1 sig
naling","MAP kinase activation","Regulation of TP53 Expression and Degradation","APC/C:Cdc20 mediated degradation of mitotic proteins","Activation of AMPK downstream of NMDARs","Biosynthesis of maresi
n-like SPMs","Regulation of TP53 Activity through Phosphorylation","Biosynthesis of DPAn-3-derived protectins and resolvins","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 
(TPL2)-dependent MAPK1/3 activation","CYP2E1 reactions","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins p
rior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CDK1,CDK2,CDK5,MAPK1}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{olomoucine,101622-51-9,101622519,"101622 51 9",Olomucine,4erk,UNII-6A839B2HYS,UNII6A839B2HYS,"UNII 6A839B2HYS",6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine,6(Benzylamino)2(2hydroxyethylamin
o)9methylpurine,"6 (Benzylamino) 2 (2 hydroxy",1284,CC-200,Olomoucine}

> <pdid>
PD002661

> <targets>
{cdk,CDK}

> <classes>
{}

> <pubchem_cids>
{4592}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -2.6071    5.9984    0.0000 O   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 N   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -5.2003   -1.4932    0.0000 C   0  0
   -6.4994   -0.7433    0.0000 C   0  0
   -7.7985   -1.4932    0.0000 C   0  0
   -7.7985   -2.9932    0.0000 C   0  0
   -6.4995   -3.7433    0.0000 C   0  0
   -5.2004   -2.9933    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
  7 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 13 22  2  0
 22  2  1  0
 22  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28136

> <plate>
Kinase v5-1

> <well>
I21

> <supplier_cmpd_name>
Iso-olomoucine

> <ctcr_id>
49

> <supplier_cmpd_id>
CC-201

> <smiles>
Cn1cnc2nc(NCCO)nc(NCc3ccccc3)c12

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SOOLOMOUCIN,"SO OLOMOUCIN",Iso-Olomoucine,IsoOlomoucine,"Iso Olomoucine",101622-50-8,101622508,"101622 50 8",6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine,6Benzylamino2(2hydroxyethylamino)7met
hylpurine,"6 Benzylamino 2 (2 hydroxyethy",CC-201,Iso-olomoucine}

> <pdid>
PD019399

> <targets>
{"Negative control for olomoucine."}

> <classes>
{}

> <pubchem_cids>
{512292}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 17  0  0  0  0            999 V2000
    3.9096   -3.7486    0.0000 C   0  0
    5.2060   -2.9940    0.0000 C   0  0
    6.5074   -3.7399    0.0000 O   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8960   -0.7508    0.0000 C   0  0
    2.5923   -0.0089    0.0000 N   0  0
    6.4959   -0.7356    0.0000 C   0  0
    6.4871    0.7644    0.0000 O   0  0
    7.8003   -1.4780    0.0000 N   0  0
    9.0958   -0.7204    0.0000 C   0  0
    9.0844    0.7796    0.0000 C   0  0
   10.3778    1.5394    0.0000 C   0  0
   10.3664    3.0394    0.0000 Br  0  0
   11.6824    0.7993    0.0000 C   0  0
   11.6938   -0.7006    0.0000 C   0  0
   10.4005   -1.4605    0.0000 C   0  0
   10.4119   -2.9604    0.0000 Br  0  0
  1  2  1  0
  2  3  1  0
  2  4  2  0
  4  5  1  0
  5  6  3  0
  4  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 14 15  1  0
 15 16  2  0
 16 10  1  0
 16 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28137

> <plate>
Kinase v5-1

> <well>
K03

> <supplier_cmpd_name>
LFM-A13

> <ctcr_id>
7671

> <supplier_cmpd_id>
EI-295

> <smiles>
C/C(O)=C(C#N)/C(=O)Nc1cc(Br)ccc1Br

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{FMA1,"FM A1",lfm-a13,lfma13,"lfm a13",244240-24-2,244240242,"244240 24 2","(Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide","(Z)2cyanoN(2,5dibromophenyl)3hydroxybut2enamide","(Z) 2 cyano N (
2,5 dibromophenyl) 3 hydroxybut 2 enamide",62004,1300,LFM-A13}

> <pdid>
PD002701

> <targets>
{BTK,Btk,JAK,"Polo-like Kinase (PLK)"}

> <classes>
{Cell Cycle/DNA Damage,Epigenetics,JAK/STAT Signaling,Protein Tyrosine Kinase/RTK,Stem Cell/Wnt}

> <pubchem_cids>
{54676905}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 N   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.8193    4.6606    0.0000 C   0  0
   -4.0353    5.9336    0.0000 C   0  0
   -4.7489    7.2530    0.0000 C   0  0
   -6.2483    7.2947    0.0000 N   0  0
   -7.0341    6.0170    0.0000 C   0  0
   -6.3205    4.6976    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -6.4469    1.8311    0.0000 C   0  0
   -7.4153    2.9701    0.0000 C   0  0
   -8.8906    2.6991    0.0000 C   0  0
   -9.3937    1.2860    0.0000 C   0  0
  -10.8690    1.0150    0.0000 F   0  0
   -8.4213    0.1438    0.0000 C   0  0
   -6.9460    0.4147    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 10 17  2  0
 17 18  1  0
 18  8  2  0
 17 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28138

> <plate>
Kinase v5-1

> <well>
K05

> <supplier_cmpd_name>
SB-202190

> <ctcr_id>
90

> <supplier_cmpd_id>
EI-294

> <smiles>
Oc1ccc(cc1)c2[nH]c(c3ccncc3)c(n2)c4ccc(F)cc4

> <pd_targets>
{EGFR,MAPK11,MAPK14,ALDH1A1,HPGD,CYP2C9,CSNK1A1,MAPK10,RIPK2,TNIK,LEF,AMPC,BRD4,BRDT,TUBA1A,PRKACA,MAPK8,BRAF,CIT,CSNK1E,MAPK12,RPS6KA1,MAPK1,ACVR1B,GSK3B,MAPK9,RAF1,GAK,PRKACB,MAP2K2,ACVR2B,COQ8B,TSH
R,ROS1,HSD17B10,KDM4E,FRK,STK36,PTK6,MAPT,BLM,TTK,CYP2C19,THPO,CDC42BPG,EPHA7,RPS6KA6,STK32B,HTR2A,ERBB4,CSNK1A1L,NTRK3,CYP2D6,CYP3A4,LATS2,IGF1R,DDR1,DDR2,SLK,NLK,CSNK1D,NTRK2,GMNN,CYP1A2,TTBK1,LMNA,
NFKB1,EPHA6,MAPK13,CDC42BPB,TTBK2,ALOX5,CLK4,PRKD3,NFO,PMP22,ALOX15,MAP4K4,GCGR,TYR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Structural protein","Membrane receptor","Other cytosolic protein","Unclassified protein","Other nuclear protein",Kinase,Oxidoreductase,"Cytochrome P450",Protease,Hydrol
ase,Reader,"Family A G protein-coupled receptor",Eraser,"Family B G protein-coupled receptor","Protein Kinase","Cytochrome P450 family 2","Metallo protease",Bromodomain,"Peptide receptor (family A GPC
R)","Lysine demethylase","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 1","Peptide receptor (family B GPCR)","TK protein kinase group","CMGC protein kina
se group","Cytochrome P450 family 2C","CK1 protein kinase group","TKL protein kinase group","STE protein kinase group","Metallo protease MAE clan","AGC protein kinase group","Other protein kinase grou
p","Atypical protein kinase group","Glycohormone receptor","Jumonji domain-containing","Monoamine receptor","Cytochrome P450 family 2D","Cytochrome P450 family 3A","Cytochrome P450 family 1A","CAMK pr
otein kinase group","Glucagon-like receptor","Tyrosine protein kinase EGFR family","CMGC protein kinase MAPK family","Cytochrome P450 2C9","CK1 protein kinase CK1 family","TKL protein kinase RIPK fami
ly","STE protein kinase STE20 family","Metallo protease M34 family","AGC protein kinase PKA family","TKL protein kinase RAF family","AGC protein kinase DMPK family","AGC protein kinase RSK family","TK
L protein kinase STKR family","CMGC protein kinase GSK family","Other protein kinase NAK family","STE protein kinase STE7 family","Atypical protein kinase ABC1 family","Tyrosine protein kinase Sev fam
ily","Tyrosine protein kinase Src family","Other protein kinase ULK family","Other protein kinase TTK family","Cytochrome P450 2C19","Tyrosine protein kinase Eph family","AGC protein kinase YANK famil
y","Serotonin receptor","Tyrosine protein kinase Trk family","Cytochrome P450 2D6","Cytochrome P450 3A4","AGC protein kinase NDR family","Tyrosine protein kinase InsR family","Tyrosine protein kinase 
DDR family","Cytochrome P450 1A1","CMGC protein kinase CLK family","CAMK protein kinase PKD family","Glucagon receptor","CMGC protein kinase p38 subfamily","CMGC protein kinase JNK subfamily","STE pro
tein kinase MSN subfamily","AGC protein kinase CRIK subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase ERK1","TKL protein kinase STKR Type 1 subfamily","TKL protein kinase STKR Type 2 
subfamily","Atypical protein kinase ABC1-A subfamily","AGC protein kinase GEK subfamily","CK1 protein kinase CK1-a","STE protein kinase SLK subfamily","CMGC protein kinase nmo subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Eicosanoid turnover","Cytochrome P450","Chromatin modifying enzymes","Bromodomain-containing proteins",Tubulins
,"G protein-coupled receptors","1.-.-.- Oxidoreductases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglandin synthases","CYP2 family: drug metabolising subset","CK1: Case
in kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Enzymatic bromodomain-containing proteins","Non-enzymatic BRD containing proteins","AGC: Containing PKA",PKG,"PKC fam
ilies",Atypical,"Glycoprotein hormone receptors","1.14.11.- Histone demethylases","5-Hydroxytryptamine receptors","CYP3 family","CYP1 family",Lipoxygenases,"CAMK: Calcium/calmodulin-dependent protein 
kinases","Glucagon receptor family","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Casein kinase 1 (CK1) family","TKL: Tyrosine kinase-like","STE20 family","Bromodomain kinas
e (BRDK) family","Protein kinase A (PKA) family","DMPK family","RSK family","Glycogen synthase kinase (GSK) family","Other protein kinases","STE7 family","ABC1 family","YANK family","NDR family","Tau 
tubulin kinase (TTBK) family","CLK family","Protein kinase D (PKD) family","Receptor tyrosine kinases (RTKs)","p38 subfamily","JNK subfamily","Receptor interacting protein kinase (RIPK) family","MSN s
ubfamily","RAF family","Other DMPK family kinases","RSK subfamily","ERK subfamily","Receptor serine/threonine kinase (RSTK) family","GSK subfamily","Numb-associated kinase (NAK) family","ABC1-B subfam
ily","Non-receptor tyrosine kinases (nRTKs)","Unc-51-like kinase (ULK) family","TTK family","GEK subfamily","SLK subfamily","nmo subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family
","Type I receptor serine/threonine kinases","Type II receptor serine/threonine kinases","Type XVII RTKs: ROS receptors","Src family","Type XIII RTKs: Ephrin receptor family","Type VII RTKs: Neurotrop
hin receptor/Trk family","Type II RTKs: Insulin receptor family","Type XVI RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Metabolism,Disease,"Cellular responses to external stimuli","Cell Cycle","Developmental Biology","Vesicle-mediated transport","Neuronal System","DNA Repair",Hemo
stasis,"Extracellular matrix organization","Organelle biogenesis and maintenance","Signaling by GPCR","Innate Immune System","Biological oxidations","Metabolism of lipids","Diseases of signal transduc
tion by growth factor receptors and second messengers","Cellular responses to stress","Infectious disease",Mitotic,"Signaling by Receptor Tyrosine Kinases","Signaling by Rho GTPases","Signaling by NOD
AL","MAPK family signaling cascades","Membrane Trafficking","Intracellular signaling by second messengers","Metabolism of amino acids and derivatives","Transmission across Chemical Synapses","DNA Doub
le-Strand Break Repair","Platelet activation","signaling and aggregation","Nervous system development","Signaling by Hippo","Non-integrin membrane-ECM interactions","Signaling by WNT","Cytokine Signal
ing in Immune system","Cilium Assembly","GPCR downstream signalling","Toll-like Receptor Cascades","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)
","Signaling by WNT in cancer","Cellular Senescence","Uptake and actions of bacterial toxins","SARS-CoV Infections","Mitotic G2-G2/M phases","Signaling by NTRKs","RHO GTPase Effectors","Regulation of 
signaling by NODAL","MAPK1/MAPK3 signaling","trans-Golgi Network Vesicle Budding","DAG and IP3 signaling","Leishmania infection","Branched-chain amino acid catabolism","PIP3 activates AKT signaling","
Mitotic G1 phase and G1/S transition","Neurotransmitter receptors and postsynaptic signal transmission","Homology Directed Repair","Platelet Aggregation (Plug Formation)","Axon guidance","GPCR ligand 
binding","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Beta-catenin independent WNT signaling","M Phase","Signaling by Interleukins","Anchoring of the basal body to the plasma m
embrane","Sphingolipid metabolism","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Melanin biosynthesis","G alpha (q) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Ethano
l oxidation","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Signaling by AMER1 mutants","Oxidative Stress Induced Senescence","Uptake and function of anthrax toxins
","Potential therapeutics for SARS","G2/M Transition","Signaling by NTRK1 (TRKA)","RHO GTPases activate CIT","SARS-CoV-1 Infection","RAF/MAP kinase cascade","Golgi Associated Vesicle Biogenesis","CaM 
pathway","Leishmania parasite growth and survival","PTEN Regulation","G1 Phase","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Anne
aling (SSA)","EPH-Ephrin signaling","Class A/1 (Rhodopsin-like receptors)","Signaling by NTRK3 (TRKC)","IGF1R signaling cascade","Ca2+ pathway","G1/S Transition","Mitotic Metaphase and Anaphase","Inte
rleukin-1 family signaling","Biosynthesis of DPA-derived SPMs","Sphingolipid de novo biosynthesis","Gastrin-CREB signalling pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Bios
ynthesis of D-series resolvins",Xenobiotics,"Truncations of AMER1 destabilize the destruction complex","Centrosome maturation","Signalling to ERKs","SARS-CoV-1 Genome Replication and Transcription","N
egative regulation of MAPK pathway","Calmodulin induced events","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of PTEN stability and activity","Cyclin D associated ev
ents in G1","Post NMDA receptor activation events","HDR through Homologous Recombination (HRR)","EPHA-mediated growth cone collapse","Amine ligand-binding receptors","Activated NTRK3 signals through P
I3K","Biosynthesis of maresins","IRS-related events triggered by IGF1R","Activation of TRKA receptors","Activation of the pre-replicative complex","Mitotic Anaphase","Interleukin-1 signaling","Biosynt
hesis of DPAn-3 SPMs","EGFR Transactivation by Gastrin","MAP kinase activation","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","Prolonged ER
K activation events","Signalling to RAS","Replication of the SARS-CoV-1 genome","Negative feedback regulation of MAPK pathway","PKA-mediated phosphorylation of CREB","ADORA2B mediated anti-inflammator
y cytokines production","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Serot
onin receptors","Long-term potentiation","Biosynthesis of maresin-like SPMs","NGF-independant TRKA activation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Nuclear Envelope (NE)
 Reassembly","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of DPAn-3-derived 13-series resolvins","Biosynthesis of DPAn-3-derived protectins and resolvins","MAPK targets/ Nuclear events m
ediated by MAP kinases","activated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","ARMS-mediated activation","p38MAPK events","PKA activation","Frs2-mediated activation","Pr
esynaptic phase of homologous DNA pairing and strand exchange","RSK activation","Initiation of Nuclear Envelope (NE) Reformation","Activation of the AP-1 family of transcription factors","CREB phospho
rylation","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,ALOX5,CHEK1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"SB 202190",152121-30-7,152121307,SB-202190,SB202190,FHPI,"SB202190 (FHPI)",4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole,4(4Fluorophenyl)2(4hydroxyphenyl)5(4pyridyl)1Himidazole,U
NII-PVX798P8GI,UNIIPVX798P8GI,4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole,4(4fluorophenyl)2(4hydroxyphenyl)5(4pyridyl)imidazole,CHEBI:79090,4-(4-(4-fluorophenyl),4(4(4fluorophenyl),T
2301,"EMD 559388",1264,EI-294,S1077,559388}

> <pdid>
PD002796

> <targets>
{"p38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{5169}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
   -0.2290   -5.5067    0.0000 C   0  0
   -0.6913   -4.0797    0.0000 C   0  0
   -2.1584   -3.7671    0.0000 C   0  0
   -1.6957   -5.1937    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    4.9619   -2.4739    0.0000 C   0  0
    6.4015   -2.0524    0.0000 C   0  0
    6.7561   -0.5949    0.0000 C   0  0
    8.1957   -0.1733    0.0000 Cl  0  0
    5.6713    0.4410    0.0000 C   0  0
    4.2318    0.0194    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14  8  1  0
  7 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21  5  1  0
 21 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28139

> <plate>
Kinase v5-1

> <well>
K07

> <supplier_cmpd_name>
PP2

> <ctcr_id>
4439

> <supplier_cmpd_id>
EI-297

> <smiles>
CC(C)(C)n1nc(c2ccc(Cl)cc2)c3c(N)ncnc13

> <pd_targets>
{RPL19A,SRC,APE1,LCK,EPHB2,FYN,SMN1,MAP2K2,TNK2,SIK2,ACVR1,HCK,RIPK2,CSK,ABL1,MAPK14,MAPK9,CYP2C19,CLK4,MELK,MAP2K1,PDGFRA,CSNK1D,PRKACA,MAPK8,CSNK1A1,BTK,CDK8,EGFR,CYP2C9,CYP1A2,CDK5,MAPK10,KDR,PDGFR
B,DAPK3}

> <pathway_gtopdb>
{"Unclassified protein",Enzyme,"Epigenetic regulator",Kinase,Protease,Reader,"Cytochrome P450","Protein Kinase","Metallo protease","Methyl-lysine/arginine binding protein","Cytochrome P450 family 2","
Cytochrome P450 family 1","TK protein kinase group","Metallo protease MH clan","Tudor domain","STE protein kinase group","CAMK protein kinase group","TKL protein kinase group","CMGC protein kinase gro
up","Cytochrome P450 family 2C","CK1 protein kinase group","AGC protein kinase group","Cytochrome P450 family 1A","Tyrosine protein kinase Src family","Metallo protease M18 family","Tyrosine protein k
inase Eph family","STE protein kinase STE7 family","Tyrosine protein kinase Ack family","CAMK protein kinase CAMK1 family","TKL protein kinase STKR family","TKL protein kinase RIPK family","Tyrosine p
rotein kinase Csk family","Tyrosine protein kinase Abl family","CMGC protein kinase MAPK family","Cytochrome P450 2C19","CMGC protein kinase CLK family","Tyrosine protein kinase PDGFR family","CK1 pro
tein kinase CK1 family","AGC protein kinase PKA family","Tyrosine protein kinase Tec family","CMGC protein kinase CDK family","Tyrosine protein kinase EGFR family","Cytochrome P450 2C9","Cytochrome P4
50 1A1","Tyrosine protein kinase VEGFR family","CAMK protein kinase DAPK family","Tyrosine protein kinase SrcA","CAMK protein kinase QIK subfamily","TKL protein kinase STKR1","CMGC protein kinase p38 
subfamily","CMGC protein kinase JNK subfamily","CAMK protein kinase MELK subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-depe
ndent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP2 family: drug metabolising subset","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","CYP1 family","TK: Tyrosi
ne kinase","STE7 family","CAMK-like (CAMKL) family","TKL: Tyrosine kinase-like","Mitogen-activated protein kinases (MAP kinases)","CLK family","Casein kinase 1 (CK1) family","Protein kinase A (PKA) fa
mily","Cyclin-dependent kinase (CDK) family","Death-associated kinase (DAPK) family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","QIK subfamily","Receptor serine/threoni
ne kinase (RSTK) family","Receptor interacting protein kinase (RIPK) family","p38 subfamily","JNK subfamily","MELK subfamily","CDK8 subfamily","CDK5 subfamily","Src family","Type XIII RTKs: Ephrin rec
eptor family","Ack family","Type I receptor serine/threonine kinases","Csk family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Tec family","Type I RTKs: ErbB (epidermal growth
 factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Developmental Biology","Metabolism of RNA","Immune System",Metabolism,"Cell Cycle","Gene expression (Transcription)","Programmed Cell Death","Signaling by Receptor Tyro
sine Kinases","Infectious disease","Nervous system development","Metabolism of non-coding RNA","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers"
,"Biological oxidations",Mitotic,"Signaling by GPCR","RNA Polymerase II Transcription","Intracellular signaling by second messengers",Apoptosis,"Signaling by NTRKs","HIV Infection","Axon guidance","sn
RNP Assembly","Toll-like Receptor Cascades","Oncogenic MAPK signaling","Leishmania infection","Phase I - Functionalization of compounds","Signaling by PDGFR in disease","Mitotic G2-G2/M phases","Signa
ling by WNT in cancer","Signaling by NOTCH1 in Cancer","GPCR downstream signalling","Generic Transcription Pathway","Signaling by VEGF","PIP3 activates AKT signaling","Caspase activation via extrinsic
 apoptotic signalling pathway","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","EPH-Ephrin signaling","Toll Like Receptor 5 (TLR5) Cascade","Signaling by RAS mutants","Parasite infectio
n","Cytochrome P450 - arranged by substrate type","Drug resistance of PDGFR mutants","G2/M Transition","Signaling by AMER1 mutants","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","G alpha (q) 
signalling events","Transcriptional Regulation by TP53","VEGFA-VEGFR2 Pathway","Negative regulation of the PI3K/AKT network","Caspase activation via Dependence Receptors in the absence of ligand","Sig
nalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis","EPHB-mediated forward signaling","MyD88 cascade initiated on plasma membrane","Signaling downstream of RAS mutants","L
eishmania phagocytosis",Xenobiotics,"Imatinib-resistant PDGFR mutants","Centrosome maturation","Truncations of AMER1 destabilize the destruction complex","Constitutive Signaling by NOTCH1 HD+PEST Doma
in Mutants","Gastrin-CREB signalling pathway via PKC and MAPK","Regulation of TP53 Activity","VEGFR2 mediated cell proliferation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signalling to RAS","
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Nef and signal transduction","Prolonged ERK activation events","MAP kinase activation","FCGR3A-mediated
 phagocytosis","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","EGFR Transactivation by Gastrin","Aromatic amines can be N-hydroxylated or N-
dealkylated by CYP1A2","Regulation of TP53 Activity through Phosphorylation","p38MAPK events","Nef Mediated CD4 Down-regulation","Frs2-mediated activation","activated TAK1 mediates p38 MAPK activation
","MAPK targets/ Nuclear events mediated by MAP kinases","Loss of Nlp from mitotic centrosomes","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{ABL1,LCK,RIPK2,SRC}

> <broad_moa>
{"SRC inhibitor"}

> <synonyms>
{172889-27-9,172889279,pp2,"PP 2","1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1(tertbutyl)3(4chlorophenyl)1Hpyrazolo(3,4d)pyrimidin4amine","AG 1879","1-tert-butyl-3-(4-chl
orophenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1tertbutyl3(4chlorophenyl)1Hpyrazolo(3,4d)pyrimidin4amine","1-tert-butyl-3-(4-chlorophenyl)pyrazolo(3,4-d)pyrimidin-4-amine","1tertbutyl3(4chlorophenyl
)pyrazolo(3,4d)pyrimidin4amine","AGL 1879",T6266,EI-297,1407,S7008,PP2}

> <pdid>
PD010654

> <targets>
{Src,"Src family"}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{4878}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    3.8976   -0.7553    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -3.8976   -0.7554    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 N   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -7.7905   -6.0071    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -7.7897   -3.0041    0.0000 N   0  0
   -7.7876   -1.5032    0.0000 C   0  0
   -6.4873   -0.7555    0.0000 O   0  0
   -9.0858   -0.7502    0.0000 C   0  0
   -9.0859    0.7498    0.0000 C   0  0
  -10.3850    1.4998    0.0000 C   0  0
  -11.6840    0.7498    0.0000 C   0  0
  -12.9831    1.4998    0.0000 O   0  0
  -11.6840   -0.7502    0.0000 C   0  0
  -10.3850   -1.5002    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  8 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 22  1  0
 18 29  2  0
 29 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28140

> <plate>
Kinase v5-1

> <well>
K09

> <supplier_cmpd_name>
ZM 336372

> <ctcr_id>
6033

> <supplier_cmpd_id>
EI-298

> <smiles>
CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2

> <pd_targets>
{ALOX15,KDM4E,MAPT,IMPA1,CYP3A4,MAPK14,RAF1,RORC,ALDH1A1,LEF,TP53,BRAF,LCK,HSD17B10,CYP1A2,MAPK11,HPGD}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Transcription factor",Oxidoreductase,Eraser,Hydrolase,"Cytochrome P450",Kinase,"Nuclear receptor",Protease,"Lysine demethylase","Cytochrome P4
50 family 3","Protein Kinase","Nuclear hormone receptor subfamily 1","Metallo protease","Cytochrome P450 family 1","Jumonji domain-containing","Cytochrome P450 family 3A","CMGC protein kinase group","
TKL protein kinase group","Nuclear hormone receptor subfamily 1 group F","Metallo protease MAE clan","TK protein kinase group","Cytochrome P450 family 1A","Cytochrome P450 3A4","CMGC protein kinase MA
PK family","TKL protein kinase RAF family","Nuclear hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Tyrosine protein kinase Src family","Cytochrome P450 1A1","CMGC protei
n kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Eicosanoid turnover","Chromatin modifying enzymes","Inositol phosphate turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","Catalytic receptors","Nuclear hormone receptors",Lipoxyge
nases,"1.14.11.- Histone demethylases","Inositol monophosphatase","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","1F. Retinoic acid-related orphans","CYP1 family","Pr
ostaglandin synthases","Mitogen-activated protein kinases (MAP kinases)","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","p38 subfamily","RAF family","Non-receptor tyrosine kinases (nRTKs)","Src fam
ily"}

> <pathway_reactome>
{Metabolism,"Neuronal System","Immune System","Signal Transduction","Gene expression (Transcription)",Disease,"Cell Cycle","Metabolism of lipids","Transmission across Chemical Synapses","Inositol phos
phate metabolism","Innate Immune System","MAPK family signaling cascades","RNA Polymerase II Transcription","Biological oxidations","Infectious disease","Cell Cycle Checkpoints","Signaling by Receptor
 Tyrosine Kinases","Metabolism of amino acids and derivatives","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotransmitter receptors and postsynaptic signal transmission","Synthesis 
of IP2",IP,"and Ins in the cytosol","Toll-like Receptor Cascades","MAPK1/MAPK3 signaling","Generic Transcription Pathway","Phase I - Functionalization of compounds","Uptake and actions of bacterial to
xins","G1/S DNA Damage Checkpoints","Signaling by NTRKs","HIV Infection","Branched-chain amino acid catabolism","Biosynthesis of DPA-derived SPMs","Activation of NMDA receptors and postsynaptic events
","Biosynthesis of DHA-derived SPMs","Toll Like Receptor 5 (TLR5) Cascade","RAF/MAP kinase cascade","Transcriptional regulation by RUNX3","Ethanol oxidation","Uptake and function of anthrax toxins","p
53-Dependent G1/S DNA damage checkpoint","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Cytochrome P450 - arranged by substrate type","Biosynthesis of DPAn-3 SPMs","Post NMDA receptor
 activation events","Biosynthesis of maresins","MyD88 cascade initiated on plasma membrane","Negative regulation of MAPK pathway","RUNX3 Regulates Immune Response and Cell Migration","p53-Dependent G1
 DNA Damage Response","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis",Xenobiotics,"Biosynthesis of D-series resolvins","Biosynthesis of DPAn-3-derived protectins a
nd resolvins","Activation of AMPK downstream of NMDARs","Biosynthesis of maresin-like SPMs","MAP kinase activation","Negative feedback regulation of MAPK pathway","Stabilization of p53","Prolonged ERK
 activation events","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAPK targets/ N
uclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","ARMS-mediated activation","Nef Mediated CD4 Down-regulation","Activation of the AP-1 family of transcription f
actors"}

> <broad_targets>
{BRAF,LCK,MAPK14,RAF1}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{"ZM 336372",208260-29-1,208260291,ZM336372,ZM-336372,3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide,3(dimethylamino)N(3(4hydroxybenzamido)4methylphenyl)benzamide,N-(5-(3-Dimethy
laminobenzamido)-2-methylphenyl)-4-hydroxybenzamide,N(5(3Dimethylaminobenzamido)2methylphenyl)4hydroxybenzamide,CHEMBL186526,3-(dimethylamino)-N-(3-((4-hydroxybenzoyl)amino)-4-,3(dimethylamino)N(3((4h
ydroxybenzoyl)amino)4,T1851,1321,S2720,EI-298}

> <pdid>
PD010695

> <targets>
{Raf,cRAF}

> <classes>
{MAPK}

> <pubchem_cids>
{5730}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    2.6531  -10.0886    0.0000 C   0  0
    1.1844   -9.7837    0.0000 N   0  0
    0.1863  -10.9034    0.0000 C   0  0
    0.7130   -8.3588    0.0000 C   0  0
   -0.7552   -8.0517    0.0000 C   0  0
   -1.2234   -6.6267    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
    1.2449   -5.8157    0.0000 C   0  0
    1.7131   -7.2408    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 11  1  0
 20 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28141

> <plate>
Kinase v5-1

> <well>
K11

> <supplier_cmpd_name>
SU 4312

> <ctcr_id>
3578

> <supplier_cmpd_id>
EI-306

> <smiles>
CN(C)c1ccc(cc1)C=C2C(=O)Nc3ccccc23

> <pd_targets>
{CSF1R,APP,FLT1,MAPT,GMNN,LMNA,RAB9A,SNCA,NPC1,PDGFRB,KMT2A,MEN1,ALDH1A1,FFP,FTL,NPSR1,HPGD,SMN1,RORC,MAPK1,BLM,NFO,PMP22,MTOR,EPHB2,PKM,THPO,CYP1A2,AMPC,CTRC,PYK,LEF,CHRM1,CYP3A4,CYP2C9,TSHR,TP53,CYP
2D6,KDR,CYP2C19}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Other cytosolic protein","Unclassified protein","Other nuclear protein",Transporter,"Epigenetic regulator","Transcription factor",Kinase,Oxidoreductase,Hydrolase,Reader,Tr
ansferase,"Family A G protein-coupled receptor","Nuclear receptor","Protein Kinase",Bromodomain,"Peptide receptor (family A GPCR)","Methyl-lysine/arginine binding protein","Nuclear hormone receptor su
bfamily 1","TK protein kinase group","Short peptide receptor (family A GPCR)","Tudor domain","Nuclear hormone receptor subfamily 1 group F","CMGC protein kinase group","Atypical protein kinase group",
"Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","Neuropeptide receptor","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase MAPK family","Atypica
l protein kinase PIKK family","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","Cytochrome P450",Protease,"Cytochrome P450 family 1","Serine protease","Metallo protease","Small mole
cule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Cytochrome P450 family 1A","Serine protease PA clan","Metallo protease MAE clan","Monoamine receptor","Cytochrome 
P450 family 3A","Cytochrome P450 family 2C","Glycohormone receptor","Cytochrome P450 family 2D","Tyrosine protein kinase Eph family","Cytochrome P450 1A1","Serine protease S1A subfamily","Metallo prot
ease M34 family","Acetylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 2C9","Cytochrome P450 2D6","Cytochrome P450 2C19"}

> <pathway_chembl>
{Receptors,Transporters,Enzymes,"Catalytic receptors","SLC superfamily of solute carriers","G protein-coupled receptors","Eicosanoid turnover","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Recep
tor kinases","SLC65 NPC-type cholesterol transporters","Neuropeptide S receptor","Prostaglandin synthases","1F. Retinoic acid-related orphans","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,
"TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Receptor tyrosine kinases (RTKs)","ERK subfamily","FRAP subfami
ly","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","2.7.1.40 Pyruvate kinases","Cytochrome P450","Peptidases and prote
inases","CYP1 family","PA: Serine (S) Peptidases","Acetylcholine receptors (muscarinic)","CYP3 family","CYP2 family: drug metabolising subset","Glycoprotein hormone receptors","S1: Chymotrypsin","Type
 XIII RTKs: Ephrin receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System","Signal Transduction","Neuronal System","Cell Cycle","Metabolism of proteins","Transport of small molecules",Metabolism,"Vesicle-mediated transport",
Disease,"Metabolism of RNA","DNA Repair","Developmental Biology","RNA Polymerase II Transcription","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Transmission across Chemical Synapse
s",Mitotic,"Signaling by Rho GTPases","Amyloid fiber formation","Plasma lipoprotein assembly",remodeling,"and clearance","Intracellular signaling by second messengers","Biological oxidations","Membran
e Trafficking","Infectious disease","Metabolism of lipids","Metabolism of non-coding RNA","DNA Double-Strand Break Repair","Nervous system development","Generic Transcription Pathway","Toll-like Recep
tor Cascades","Signaling by VEGF","Neurotransmitter receptors and postsynaptic signal transmission","Mitotic G1 phase and G1/S transition","M Phase","Rho GTPase cycle","Plasma lipoprotein clearance","
PIP3 activates AKT signaling","Phase I - Functionalization of compounds","trans-Golgi Network Vesicle Budding","Leishmania infection","Biosynthesis of specialized proresolving mediators (SPMs)","snRNP
 Assembly","Homology Directed Repair","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Transcriptional Regulation by VENTX","Toll Like Receptor 5 (TLR5) Cascade","VEGF ligand-receptor
 interactions","Activation of NMDA receptors and postsynaptic events","G1/S Transition","Mitotic Metaphase and Anaphase","RHOBTB GTPase Cycle","LDL clearance","Negative regulation of the PI3K/AKT netw
ork","Ethanol oxidation","Golgi Associated Vesicle Biogenesis","Leishmania parasite growth and survival","Biosynthesis of DHA-derived SPMs","Transcriptional regulation by RUNX3","HDR through Homologou
s Recombination (HRR) or Single Strand Annealing (SSA)","Transcriptional Regulation by TP53","MyD88 cascade initiated on plasma membrane","VEGF binds to VEGFR leading to receptor dimerization","Post N
MDA receptor activation events","Activation of the pre-replicative complex","Mitotic Anaphase","RHOBTB3 ATPase cycle",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Anti-inflammatory response favou
ring Leishmania parasite infection","Biosynthesis of D-series resolvins","RUNX3 Regulates Immune Response and Cell Migration","HDR through Homologous Recombination (HRR)","Regulation of TP53 Activity"
,"TAK1 activates NFkB by phosphorylation and activation of IKKs complex","Activation of AMPK downstream of NMDARs","Nuclear Envelope (NE) Reassembly","ADORA2B mediated anti-inflammatory cytokines prod
uction","MAP kinase activation","Homologous DNA Pairing and Strand Exchange","Regulation of TP53 Expression and Degradation","Initiation of Nuclear Envelope (NE) Reformation","MAPK targets/ Nuclear ev
ents mediated by MAP kinases","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation","ERK/MAPK targets","ERKs are inactivated",Hemostasis,"Metabolism of car
bohydrates","Platelet activation","signaling and aggregation","Metabolism of vitamins and cofactors","Signaling by GPCR","Cell Cycle Checkpoints","Axon guidance","Glucose metabolism","Platelet Aggrega
tion (Plug Formation)","Metabolism of water-soluble vitamins and cofactors","Uptake and actions of bacterial toxins","GPCR ligand binding","G1/S DNA Damage Checkpoints","EPH-Ephrin signaling",Glycolys
is,"Cytochrome P450 - arranged by substrate type","Cobalamin (Cbl","vitamin B12) transport and metabolism","Uptake and function of anthrax toxins","Class A/1 (Rhodopsin-like receptors)","p53-Dependent
 G1/S DNA damage checkpoint","VEGFA-VEGFR2 Pathway","EPHB-mediated forward signaling",Xenobiotics,"Amine ligand-binding receptors","Biosynthesis of maresins","p53-Dependent G1 DNA Damage Response","VE
GFR2 mediated cell proliferation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","Stabil
ization of p53","Autodegradation of the E3 ubiquitin ligase COP1"}

> <broad_targets>
{KDR,PDGFRB}

> <broad_moa>
{"PDGFR tyrosine kinase receptor inhibitor","tyrosine kinase inhibitor","VEGFR inhibitor"}

> <synonyms>
{SU4312,3-(4-dimethylamino-benzylidenyl)-2-indolinone,3(4dimethylaminobenzylidenyl)2indolinone,5812-07-7,5812077,3-((4-(dimethylamino)phenyl)methylidene)-1H-indol-2-one,3((4(dimethylamino)phenyl)methy
lidene)1Hindol2one,dmbi,KBioGR_000338,KBioGR000338,KBioGR-000338,"KBioGR 000338",KBioSS_000338,KBioSS000338,KBioSS-000338,"KBioSS 000338",CHEBI:92369,KBio2_000338,KBio2000338,KBio2-000338,"KBio2 00033
8",KBio2_002906,KBio2002906,KBio2-002906,"KBio2 002906",KBio2_005474,KBio2005474,KBio2-005474,"KBio2 005474",KBio3_000675,KBio3000675,KBio3-000675,"KBio3 000675",KBio3_000676,KBio3000676,KBio3-000676,
"KBio3 000676",Bio2_000339,Bio2000339,Bio2-000339,"Bio2 000339",Bio2,"EMD 317200",EI-306,1459,317200,"SU 4312"}

> <pdid>
PD015018

> <targets>
{VEGFR,Flk1}

> <classes>
{}

> <pubchem_cids>
{3135}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
   -3.8978    3.7504    0.0000 C   0  0
   -3.9003    5.2504    0.0000 C   0  0
   -5.2005    5.9983    0.0000 C   0  0
   -6.4984    5.2463    0.0000 C   0  0
   -6.4960    3.7463    0.0000 C   0  0
   -5.1957    2.9983    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 10 11  1  0
 11 12  2  0
 12  3  1  0
 12 13  1  0
 13 14  1  0
  8 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28142

> <plate>
Kinase v5-1

> <well>
K13

> <supplier_cmpd_name>
AG-1296

> <ctcr_id>
5517

> <supplier_cmpd_id>
EI-303

> <smiles>
COc1cc2ncc(nc2cc1OC)c3ccccc3

> <pd_targets>
{GAA,SMN1,MAPT,GLA,ALDH1A1,PDGFRA,PDGFRB}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein",Hydrolase,Reader,Oxidoreductase,Kinase,"Methyl-lysine/arginine binding protein","Protein Kinase","Tudor domain","TK protein kinase group","Tyro
sine protein kinase PDGFR family"}

> <pathway_chembl>
{Enzymes,"3.2.1.- Glycosidases"}

> <pathway_reactome>
{Disease,"Metabolism of RNA","Neuronal System",Metabolism,"Diseases of metabolism","Metabolism of non-coding RNA","Transmission across Chemical Synapses","Metabolism of lipids","Biological oxidations"
,"Diseases of carbohydrate metabolism","snRNP Assembly","Neurotransmitter receptors and postsynaptic signal transmission","Sphingolipid metabolism","Phase I - Functionalization of compounds","Glycogen
 storage diseases","Activation of NMDA receptors and postsynaptic events","Glycosphingolipid metabolism","Ethanol oxidation","Glycogen storage disease type II (GAA)","Post NMDA receptor activation eve
nts","Activation of AMPK downstream of NMDARs"}

> <broad_targets>
{FLT3}

> <broad_moa>
{"FLT3 inhibitor"}

> <synonyms>
{G129,146535-11-7,146535117,"Tyrphostin AG 1296","6,7-dimethoxy-2-phenylquinoxaline","6,7dimethoxy2phenylquinoxaline",AG-1296,AG1296,"AG 1296","6,7-Dimethoxy-3-phenylquinoxaline","6,7Dimethoxy3phenylq
uinoxaline",ag1296,"Quinoxaline, 6,7-dimethoxy-2-phenyl-","Quinoxaline, 6,7dimethoxy2phenyl","Tyrphostin AG-1296","Tyrphostin AG1296",CHEMBL71191,MFCD00270913,tyrphostin-A,tyrphostinA,T6711,"EMD 65855
1",EI-303,658551}

> <pdid>
PD002754

> <targets>
{PDGFRK,Apoptosis,c-Kit,FLT3,PDGFR}

> <classes>
{Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{2049}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
    1.1812   -9.7838    0.0000 O   0  0
    0.7130   -8.3588    0.0000 C   0  0
   -0.7552   -8.0517    0.0000 C   0  0
   -1.7553   -9.1697    0.0000 Br  0  0
   -1.2234   -6.6267    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
    1.2449   -5.8157    0.0000 C   0  0
    1.7131   -7.2408    0.0000 C   0  0
    3.1813   -7.5478    0.0000 Br  0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 I   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  6 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 11  1  0
 21 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28143

> <plate>
Kinase v5-1

> <well>
K15

> <supplier_cmpd_name>
GW 5074

> <ctcr_id>
7258

> <supplier_cmpd_id>
EI-307

> <smiles>
Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23

> <pd_targets>
{REP,BRAF,RAF1,PIM2,MAPK3,MAP3K20,RECQL,MAPT,HIF1A,MAPK1,STAT6,RORC,CHRM1,HPGD,HBB,CYP2D6,PLK4,LMNA,ARAF,FTL,KMT2A,MEN1,HSD17B10,CYP2C19,FFP,ALOX15,APEX1,BRCA1,NFKB1,TSHR,BLM,PMP22,CYP2C9,USP2,DYRK4,R
IPK3,THRB,CYP3A4,PLK1,CSNK2A1,LEF,MYOC,POLB,GMNN,CYP1A2,KIF15,MTOR,LRRK2,APH1A,APH1B,NCSTN,PSEN1,PSEN2,PSENEN}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","TKL protein kinase group","CAMK protein kinase group","CMGC protein kinase group","TKL protein kinase RAF family","CAMK protein kinase PIM family","CMGC pr
otein kinase MAPK family","CMGC protein kinase ERK1","Other cytosolic protein","Transcription factor","Membrane receptor","Secreted protein","Other nuclear protein","Unclassified protein","Epigenetic 
regulator","Nuclear receptor","Family A G protein-coupled receptor","Cytochrome P450",Reader,Oxidoreductase,Protease,"Nuclear hormone receptor subfamily 1","Small molecule receptor (family A GPCR)","C
ytochrome P450 family 2",Bromodomain,"Peptide receptor (family A GPCR)","Cysteine protease","Cytochrome P450 family 3","Metallo protease","Cytochrome P450 family 1","Nuclear hormone receptor subfamily
 1 group F","Monoamine receptor","Cytochrome P450 family 2D","Other protein kinase group","Cytochrome P450 family 2C","Glycohormone receptor","Cysteine protease CA clan","Nuclear hormone receptor subf
amily 1 group A","Cytochrome P450 family 3A","Metallo protease MAE clan","Cytochrome P450 family 1A","Atypical protein kinase group","TKL protein kinase MLK family","Nuclear hormone receptor subfamily
 1 group F member 3","Acetylcholine receptor","Cytochrome P450 2D6","Other protein kinase PLK family","Cytochrome P450 2C19","Cytochrome P450 2C9","Cysteine protease C19 family","CMGC protein kinase D
YRK family","Nuclear hormone receptor subfamily 1 group A member 2","Cytochrome P450 3A4","Other protein kinase CK2 family","Cysteine protease C1A family","Metallo protease M34 family","Cytochrome P45
0 1A1","Atypical protein kinase PIKK family","TKL protein kinase MLK subfamily","Atypical protein kinase FRAP subfamily","Aspartic protease","Aspartic protease AD clan","TKL protein kinase LRRK family
","Aspartic protease A22A subfamily","Aspartic protease A22A regulatory subfamily"}

> <pathway_chembl>
{"Other protein targets",Receptors,Enzymes,"Anti-infective targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Viral protein targets","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein 
kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Coronavirus (CoV) proteins","TKL: Tyrosine kinase-like","PIM family","Mitogen-activated protein kinases (MAP kinases)","RAF family","ERK subfa
mily","Transcription factors","Nuclear hormone receptors","G protein-coupled receptors","Eicosanoid turnover","Cytochrome P450","Chromatin modifying enzymes","Peptidases and proteinases","STAT transcr
iption factors","1F. Retinoic acid-related orphans","Acetylcholine receptors (muscarinic)","Prostaglandin synthases","CYP2 family: drug metabolising subset","2.1.1.43 Histone methyltransferases (HMTs)
",Lipoxygenases,"Glycoprotein hormone receptors","CA: Cysteine (C) Peptidases","1A. Thyroid hormone receptors","CYP3 family","CYP1 family",Atypical,"Other protein kinases","C19: Ubiquitin-specific pro
tease","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Mixed Lineage Kinase (MLK) family","Polo-like kin
ase (PLK) family","Dyrk1 subfamily","Receptor interacting protein kinase (RIPK) family","Casein kinase 2 (CK2) family","FRAP subfamily","MLK subfamily","Leucine-rich repeat kinase (LRRK) family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Immune System","Infectious disease","Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","Innate Immune System","SARS-CoV Infections","Signaling by
 NTRKs","MAPK1/MAPK3 signaling","Toll-like Receptor Cascades","SARS-CoV-2 Infection","Signaling by NTRK1 (TRKA)","RAF/MAP kinase cascade","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-2 Genome Repli
cation and Transcription","Signalling to ERKs","Negative regulation of MAPK pathway","MyD88 cascade initiated on plasma membrane","Replication of the SARS-CoV-2 genome","Prolonged ERK activation event
s","Negative feedback regulation of MAPK pathway","MAP kinase activation","ARMS-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated","N
euronal System","Cellular responses to external stimuli","Gene expression (Transcription)",Metabolism,"Cell Cycle","Vesicle-mediated transport","DNA Repair","Developmental Biology","Metabolism of prot
eins","Transmission across Chemical Synapses","Cellular responses to stress","RNA Polymerase II Transcription","Signaling by GPCR","Metabolism of lipids","Biological oxidations",Mitotic,"Diseases of s
ignal transduction by growth factor receptors and second messengers","Membrane Trafficking","Metabolism of amino acids and derivatives","Base Excision Repair","DNA Double-Strand Break Repair","Cytokin
e Signaling in Immune system","Nervous system development","Post-translational protein modification","Neurotransmitter receptors and postsynaptic signal transmission","Cellular response to hypoxia","C
ytosolic sensors of pathogen-associated DNA","Generic Transcription Pathway","GPCR ligand binding","Biosynthesis of specialized proresolving mediators (SPMs)","Neutrophil degranulation","Phase I - Fun
ctionalization of compounds","Mitotic G2-G2/M phases","M Phase","Oncogenic MAPK signaling","trans-Golgi Network Vesicle Budding","Branched-chain amino acid catabolism","Resolution of Abasic Sites (AP 
sites)","Homology Directed Repair","Signaling by Interleukins","Leishmania infection","EGR2 and SOX10-mediated initiation of Schwann cell myelination",SUMOylation,"Uptake and actions of bacterial toxi
ns","Mitotic G1 phase and G1/S transition","Intra-Golgi and retrograde Golgi-to-ER traffic","Activation of NMDA receptors and postsynaptic events","Oxygen-dependent proline hydroxylation of Hypoxia-in
ducible Factor Alpha","STING mediated induction of host immune responses","Transcriptional regulation by RUNX3","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Cytochrome P4
50 - arranged by substrate type","G2/M Transition","Mitotic Metaphase and Anaphase","Signaling by RAS mutants","Golgi Associated Vesicle Biogenesis","Transcriptional regulation by RUNX1","Biosynthesis
 of DPA-derived SPMs","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Interleukin-1 family
 signaling","Leishmania parasite growth and survival","Transcriptional Regulation by TP53","Toll Like Receptor 4 (TLR4) Cascade","SUMO E3 ligases SUMOylate target proteins","Uptake and function of ant
hrax toxins","G1/S Transition","Golgi-to-ER retrograde transport","Post NMDA receptor activation events","STAT6-mediated induction of chemokines","RUNX3 Regulates Immune Response and Cell Migration","
Amine ligand-binding receptors","Biosynthesis of D-series resolvins",Xenobiotics,"Centrosome maturation","Mitotic Anaphase","Signaling downstream of RAS mutants","RUNX1 regulates genes involved in meg
akaryocyte differentiation and platelet function","Biosynthesis of DPAn-3 SPMs","PCNA-Dependent Long Patch Base Excision Repair","HDR through Homologous Recombination (HRR)","Interleukin-1 signaling",
"Anti-inflammatory response favouring Leishmania parasite infection","Regulation of TP53 Activity","MyD88-independent TLR4 cascade","SUMOylation of intracellular receptors","Biosynthesis of maresins",
"Activation of the pre-replicative complex","COPI-dependent Golgi-to-ER retrograde traffic","Activation of AMPK downstream of NMDARs","Muscarinic acetylcholine receptors","CYP2E1 reactions","Loss of p
roteins required for interphase microtubule organization from the centrosome","Nuclear Envelope (NE) Reassembly","Biosynthesis of DPAn-3-derived protectins and resolvins","Homologous DNA Pairing and S
trand Exchange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","ADORA2B mediated anti-inflammatory cytokines production","Regulation of TP53 Expression and Degradation","TRIF(TICAM1)-mediated TLR4 signa
ling","Biosynthesis of maresin-like SPMs","Regulation of TP53 Activity through Phosphorylation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Loss of Nlp from mitotic centrosomes
","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation","IKK complex recruitment mediated by RIP1","Signa
ling by Non-Receptor Tyrosine Kinases","Signaling by PTK6","PTK6 promotes HIF1A stabilization"}

> <broad_targets>
{NTRK1,RAF1}

> <broad_moa>
{"leucine rich repeat kinase inhibitor","RAF inhibitor"}

> <synonyms>
{"Raf1 Kinase Inhibitor I",gw5074,220904-83-6,220904836,"GW 5074",GW-5074,GW5074,UNII-B7W8RS1GG2,UNIIB7W8RS1GG2,B7W8RS1GG2,"(3Z)-3-((3,5-dibromo-4-hydroxyphenyl)methylidene)-5-iodo-1H-indol-2-one","(3
Z)3((3,5dibromo4hydroxyphenyl)methylidene)5iodo1Hindol2one","3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one","3(3,5Dibromo4hydroxybenzylidene)5iodo1,3dihydroindol2one",CHEMBL7236
5,3,1381,S2872}

> <pdid>
PD002729

> <targets>
{Raf}

> <classes>
{}

> <pubchem_cids>
{5924208}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 27  0  0  0  0            999 V2000
   28.4998    2.2501    0.0000 Cl  0  5
    0.0007    0.0004    0.0000 C   0  0
    1.3000    0.7500    0.0000 C   0  0
    2.6000    0.0000    0.0000 C   0  0
    3.9000    0.7500    0.0000 C   0  0
    5.2000    0.0000    0.0000 C   0  0
    6.5000    0.7500    0.0000 C   0  0
    7.7999    0.0000    0.0000 C   0  0
    9.0999    0.7500    0.0000 C   0  0
   10.3999    0.0000    0.0000 C   0  0
   11.6999    0.7500    0.0000 C   0  0
   12.9999    0.0000    0.0000 C   0  0
   14.2999    0.7500    0.0000 C   0  0
   15.5999    0.0000    0.0000 C   0  0
   16.8999    0.7500    0.0000 C   0  0
   18.1999    0.0000    0.0000 C   0  0
   19.4998    0.7500    0.0000 C   0  0
   19.4998    2.2500    0.0000 O   0  0
   20.7998    0.0000    0.0000 O   0  0
   22.0998    0.7500    0.0000 C   0  0
   23.3998    0.0000    0.0000 C   0  0
   24.6998    0.7500    0.0000 C   0  0
   24.6998    1.7500    0.0000 O   0  0
   25.9991    0.0004    0.0000 O   0  0
   22.1029    2.2508    0.0000 C   0  0
   23.4037    2.9994    0.0000 N   0  3
   23.4068    4.4994    0.0000 C   0  0
   24.7042    3.7469    0.0000 C   0  0
   24.2689    2.4979    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 20 25  1  0
 25 26  1  0
 26 27  1  0
 26 28  1  0
 26 29  1  0
M  CHG  2   1  -1  26   1
M  END
> <name>
UTKinase_V5

> <id>
28144

> <plate>
Kinase v5-1

> <well>
K17

> <supplier_cmpd_name>
Palmitoyl-DL-carnitine

> <ctcr_id>
6056

> <supplier_cmpd_id>
AC-1121

> <smiles>
[Cl-].CCCCCCCCCCCCCCCC(=O)OC(CC(O)=O)C[N+](C)(C)C

> <pd_targets>
{CYP1A2,NFO,NPSR1,MAPT,PMP22,GLA,FTL,MAPK1,GMNN,LMNA,HIF1A,TP53,CHRM1,TSHR,LEF}

> <pathway_gtopdb>
{Enzyme,Protease,"Cysteine protease","Cysteine protease CA clan","Cysteine protease C1A family","Cytochrome P450","Cytochrome P450 family 1","Cytochrome P450 family 1A","Cytochrome P450 1A1","Membrane
 receptor","Other cytosolic protein","Unclassified protein","Other nuclear protein",Hydrolase,"Family A G protein-coupled receptor",Kinase,"Peptide receptor (family A GPCR)","Protein Kinase","Short pe
ptide receptor (family A GPCR)","CMGC protein kinase group","Neuropeptide receptor","CMGC protein kinase MAPK family","CMGC protein kinase ERK1","Transcription factor","Small molecule receptor (family
 A GPCR)","Monoamine receptor","Glycohormone receptor","Acetylcholine receptor","Metallo protease","Metallo protease MAE clan","Metallo protease M34 family"}

> <pathway_chembl>
{Enzymes,"Cytochrome P450","CYP1 family",Receptors,"G protein-coupled receptors","Kinases (EC 2.7.x.x)","Neuropeptide S receptor","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated pro
tein kinases (MAP kinases)","ERK subfamily","Acetylcholine receptors (muscarinic)","Glycoprotein hormone receptors"}

> <pathway_reactome>
{Metabolism,"Biological oxidations","Phase I - Functionalization of compounds","Cytochrome P450 - arranged by substrate type",Xenobiotics,"Aromatic amines can be N-hydroxylated or N-dealkylated by CYP
1A2",Disease,"Neuronal System","Developmental Biology","Vesicle-mediated transport","Immune System","Cell Cycle","Infectious disease","Transmission across Chemical Synapses","Nervous system developmen
t","Metabolism of lipids","Membrane Trafficking","Innate Immune System",Mitotic,"Leishmania infection","Neurotransmitter receptors and postsynaptic signal transmission","EGR2 and SOX10-mediated initia
tion of Schwann cell myelination","Sphingolipid metabolism","trans-Golgi Network Vesicle Budding","Toll-like Receptor Cascades","Mitotic G1 phase and G1/S transition","M Phase","Leishmania parasite gr
owth and survival","Activation of NMDA receptors and postsynaptic events","Glycosphingolipid metabolism","Golgi Associated Vesicle Biogenesis","Toll Like Receptor 5 (TLR5) Cascade","G1/S Transition","
Mitotic Metaphase and Anaphase","Anti-inflammatory response favouring Leishmania parasite infection","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","Activation of 
the pre-replicative complex","Mitotic Anaphase","ADORA2B mediated anti-inflammatory cytokines production","Activation of AMPK downstream of NMDARs","MAP kinase activation","Nuclear Envelope (NE) Reass
embly","MAPK targets/ Nuclear events mediated by MAP kinases","Initiation of Nuclear Envelope (NE) Reformation","ERK/MAPK targets","ERKs are inactivated","Cellular responses to external stimuli","Sign
al Transduction","Cellular responses to stress","Cell Cycle Checkpoints","Signaling by GPCR","Cellular response to hypoxia","G1/S DNA Damage Checkpoints","GPCR ligand binding","Oxygen-dependent prolin
e hydroxylation of Hypoxia-inducible Factor Alpha","p53-Dependent G1/S DNA damage checkpoint","Class A/1 (Rhodopsin-like receptors)","p53-Dependent G1 DNA Damage Response","Amine ligand-binding recept
ors","Stabilization of p53","Muscarinic acetylcholine receptors","Autodegradation of the E3 ubiquitin ligase COP1","Uptake and actions of bacterial toxins","Uptake and function of anthrax toxins"}

> <broad_targets>
{}

> <broad_moa>
{"protein kinase inhibitor"}

> <synonyms>
{ALMITOYLDLCARNITIN,"Palmitoyl carnitine hydrochloride",DTXSID20988336,"palmitoyl-dl-carnitine chloride","palmitoyldlcarnitine chloride",6865-14-1,6865141,"(+/-)-Palmitoylcarnitine chloride","(+/)Palm
itoylcarnitine chloride","Palmitoylcarnitine (chloride)","3-carboxy-n,n,n-trimethyl-2-(palmitoyloxy)propan-1-aminium chloride","3carboxyn,n,ntrimethyl2(palmitoyloxy)propan1aminium chloride",AC-1121,Pa
lmitoyl-DL-carnitine}

> <pdid>
PD071111

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{46870494,363417}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 41  0  0  0  0            999 V2000
   -0.0234   -7.4927    0.0000 C   0  0
   -0.0156   -5.9927    0.0000 C   0  0
   -1.3109   -5.2364    0.0000 O   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    2.5796   -7.5040    0.0000 O   0  0
    3.8864   -5.2585    0.0000 C   0  0
    5.1828   -6.0130    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    5.1932   -3.0130    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5627    4.4996    0.0000 C   0  0
   -3.8792    2.2197    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -2.5000    0.0000 O   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -3.8976   -0.7554    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8912   -5.2578    0.0000 C   0  0
   -5.1876   -6.0124    0.0000 C   0  0
   -5.1824   -7.5124    0.0000 C   0  0
   -3.8808   -8.2579    0.0000 C   0  0
   -2.5843   -7.5034    0.0000 C   0  0
   -2.5895   -6.0034    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    0.4292   -3.2465    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  7  9  2  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  1  0
 19 21  1  0
 19 22  1  0
 22 23  1  0
 23 16  2  0
 23 24  1  0
 24 25  2  0
 25 13  1  0
 25 26  1  0
 24 27  1  0
 27 28  2  0
 27 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 31  1  0
 11 37  2  0
 37  4  1  0
 37 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28145

> <plate>
Kinase v5-1

> <well>
K19

> <supplier_cmpd_name>
Rottlerin

> <ctcr_id>
7703

> <supplier_cmpd_id>
EI-270

> <smiles>
CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3C=CC(C)(C)Oc3c(c2O)C(=O)\C=C\c4ccccc4)c1O

> <pd_targets>
{KCNH2,AMPC,MAPKAPK5,PRKCD,MAPT,PMP22,BLM,POLB,RECQL,FTL,MAPKAPK2,WDR48,MDH,CTRB1,KDM4E,ALDH1A1,NS1,KMT2A,MEN1,USP1,LMNA,GMNN,NPSR1}

> <pathway_gtopdb>
{"Ion channel",Enzyme,"Other cytosolic protein","Unclassified protein","Epigenetic regulator","Other nuclear protein","Membrane receptor","Voltage-gated ion channel",Hydrolase,Kinase,Oxidoreductase,Pr
otease,Eraser,Reader,"Family A G protein-coupled receptor","Potassium channels","Protein Kinase","Serine protease","Lysine demethylase","Cysteine protease",Bromodomain,"Peptide receptor (family A GPCR
)","Voltage-gated potassium channel","CAMK protein kinase group","AGC protein kinase group","Serine protease PA clan","Jumonji domain-containing","Cysteine protease CA clan","Short peptide receptor (f
amily A GPCR)","CAMK protein kinase MAPKAPK family","AGC protein kinase PKC family","Serine protease S1A subfamily","Cysteine protease C1A family","Cysteine protease C19 family","Neuropeptide receptor
","CAMK protein kinase MAPKAPK subfamily","AGC protein kinase PKC delta subfamily"}

> <pathway_chembl>
{"Ion channels",Enzymes,Receptors,"Voltage-gated ion channels","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","G protein-coupled receptors","Potassium channels","CAMK: Calcium/calmodulin-depende
nt protein kinases","AGC: Containing PKA",PKG,"PKC families","1.14.11.- Histone demethylases","Neuropeptide S receptor","Voltage-gated potassium channels","MAPK-Activated Protein Kinase (MAPKAPK) fami
ly","Protein kinase C (PKC) family","MAPKAPK subfamily","Delta subfamily"}

> <pathway_reactome>
{"Muscle contraction","Gene expression (Transcription)","Signal Transduction","Neuronal System","Developmental Biology","DNA Repair","Vesicle-mediated transport","Immune System",Disease,Metabolism,"Ce
ll Cycle","Cardiac conduction","RNA Polymerase II Transcription","Intracellular signaling by second messengers","Transmission across Chemical Synapses","Nervous system development","DNA Double-Strand 
Break Repair","Base Excision Repair","Membrane Trafficking","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of vitamins and cofact
ors","Biological oxidations",Mitotic,"Infectious disease","Phase 3 - rapid repolarisation","Generic Transcription Pathway","DAG and IP3 signaling","Neurotransmitter receptors and postsynaptic signal t
ransmission","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Homology Directed Repair","Resolution of Abasic Sites (AP sites)","trans-Golgi Network Vesicle Budding","Toll-like Recept
or Cascades","Signaling by PDGFR in disease","Metabolism of water-soluble vitamins and cofactors","Phase I - Functionalization of compounds","M Phase","Mitotic G1 phase and G1/S transition","Leishmani
a infection","Transcriptional Regulation by TP53","CaM pathway","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Re
solution of AP sites via the multiple-nucleotide patch replacement pathway","Golgi Associated Vesicle Biogenesis","Toll Like Receptor 5 (TLR5) Cascade","Signaling by cytosolic PDGFRA and PDGFRB fusion
 proteins","Cobalamin (Cbl","vitamin B12) transport and metabolism","Ethanol oxidation","Mitotic Metaphase and Anaphase","G1/S Transition","Leishmania parasite growth and survival","Regulation of TP53
 Activity","Calmodulin induced events","Post NMDA receptor activation events","HDR through Homologous Recombination (HRR)","PCNA-Dependent Long Patch Base Excision Repair","MyD88 cascade initiated on 
plasma membrane","Mitotic Anaphase","Activation of the pre-replicative complex","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of TP53 Activity through Phosphorylatio
n","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","MAP kinase activation","Nuclear Envelope (NE) Reassembly","ADORA2B mediated anti-inflammatory cytokines produ
ction","Presynaptic phase of homologous DNA pairing and strand exchange","MAPK targets/ Nuclear events mediated by MAP kinases","Initiation of Nuclear Envelope (NE) Reformation","CREB phosphorylation"
}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{rottlerin,Mallotoxin,82-08-6,82086,Kamalin,UNII-E29LP3ZMUH,UNIIE29LP3ZMUH,E29LP3ZMUH,CHEMBL34241,CHEBI:8899,NSC56346,NSC94525,MFCD00017361,SR-01000076106,SR01000076106,"EINECS 201-395-4","EINECS 2013
954","NSC 56346","NSC 94525","BRN 0070757",BMK1-F10,BMK1F10,"Rottlerin, 98","R5648 (Rottlerin)",BiomolKI_0,BiomolKI0,BiomolKI-0,"BiomolKI 0",EI-270,Rottlerin}

> <pdid>
PD014867

> <targets>
{"PKC delta"}

> <classes>
{}

> <pubchem_cids>
{5281847}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 11  1  0
 18 19  1  0
 19  8  1  0
 19 20  2  0
M  END
> <name>
UTKinase_V5

> <id>
28146

> <plate>
Kinase v5-1

> <well>
K21

> <supplier_cmpd_name>
Genistein

> <ctcr_id>
2985

> <supplier_cmpd_id>
EI-147

> <smiles>
Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O

> <pd_targets>
{ALDH1A1,TSHR,SMN1,PMP22,MAPT,CYP2C19,ALOX15,AKR1B1,SLC2A1,MAOA,ESR2,XDH,PYK,MAPK1,NPC1,ESR1,MAL32,EGFR,ABL1,MGAM,ADORA2A,ADORA1,ESRRA,PTGS1,HPGD,TP53,CYP1A2,HSD17B3,HSD17B2,POL,MAOB,MAPK14,DPP3,SRC,N
A,ESRRB,LMNA,SYK,CYP3A4,AOX1,PFMRK,AR,CFTR,ABCB1,KMT2A,MEN1,RAB9A,HIF1A,LEF,THPO,PSMB5,ODC1,DAPK1,NANH,FABZ,TDP1,SHBG,DPP4,FTL,PKM,PRKCA,POLB,RORC,SLCO1B1,DNMT1,CACNA1C,NR1H2,CYP19A1,ABCG2,SLC2A4,NR1H
3,HTR2A,SLC6A3,SLCO1B3,BMX,HSD17B1,HTR2C,TBXAS1,STAT3,FYN,TRPC5,ESRRG}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Epigenetic regulator","Unclassified protein","Other cytosolic protein",Transporter,"Transcription factor","Other nuclear protein","Ion channel","Secreted protein",Oxidored
uctase,"Family A G protein-coupled receptor",Reader,"Cytochrome P450",Protease,"Electrochemical transporter","Nuclear receptor",Transferase,Kinase,Hydrolase,"Other ion channel","Primary active transpo
rter",Lyase,Writer,"Voltage-gated ion channel","Peptide receptor (family A GPCR)","Methyl-lysine/arginine binding protein","Cytochrome P450 family 2","Cysteine protease","SLC superfamily of solute car
riers","Nuclear hormone receptor subfamily 3","Protein Kinase","Small molecule receptor (family A GPCR)","Cytochrome P450 family 1","Metallo protease","Cytochrome P450 family 3","Chloride channel","AT
P-binding cassette",Bromodomain,"Threonine protease","Serine protease","Nuclear hormone receptor subfamily 1","DNA methyltransferase","Voltage-gated calcium channel","Cytochrome P450 family 19","Cytoc
hrome P450 family 5","Transient receptor potential channel","Glycohormone receptor","Tudor domain","Cytochrome P450 family 2C","Cysteine protease CA clan","SLC02 family of hexose and sugar alcohol tra
nsporters","Nuclear hormone receptor subfamily 3 group A","CMGC protein kinase group","TK protein kinase group","Nucleotide-like receptor (family A GPCR)","Nuclear hormone receptor subfamily 3 group B
","Cytochrome P450 family 1A","Metallo protease MAE clan","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 3 group C","Cystic fibrosis transmembrane conductance regulator","ABCB subfami
ly","Threonine protease PBT clan","CAMK protein kinase group","Serine protease SC clan","AGC protein kinase group","Nuclear hormone receptor subfamily 1 group F","SLC21/SLCO family of organic anion tr
ansporting polypeptides","Nuclear hormone receptor subfamily 1 group H","Cytochrome P450 family 19A","ABCG subfamily","Monoamine receptor","SLC06 neurotransmitter transporter family","Cytochrome P450 
family 5A","Cytochrome P450 2C19","Cysteine protease C1A family","Nuclear hormone receptor subfamily 3 group A member 2","CMGC protein kinase MAPK family","Nuclear hormone receptor subfamily 3 group A
 member 1","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Abl family","Adenosine receptor","Nuclear hormone receptor subfamily 3 group B member 1","Cytochrome P450 1A1","Metallo protea
se M49 family","Tyrosine protein kinase Src family","Nuclear hormone receptor subfamily 3 group B member 2","Tyrosine protein kinase Syk family","Cytochrome P450 3A4","CMGC protein kinase CDK family",
"Nuclear hormone receptor subfamily 3 group C member 4","Metallo protease M34 family","Threonine protease T1A subfamily","CAMK protein kinase DAPK family","Serine protease S9B subfamily","AGC protein 
kinase PKC family","Nuclear hormone receptor subfamily 1 group F member 3","Nuclear hormone receptor subfamily 1 group H member 3","Cytochrome P450 19A1","Serotonin receptor","Tyrosine protein kinase 
Tec family","Cytochrome P450 5A1","Nuclear hormone receptor subfamily 3 group B member 3","CMGC protein kinase ERK1","CMGC protein kinase p38 subfamily","AGC protein kinase PKC alpha subfamily","Tyros
ine protein kinase SrcA"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Ion channels","Other protein targets","G protein-coupled receptors","Cytochrome P450","Eicosanoid turnover","1.-.-.- Oxidoreductases","SLC superfamily of solute carrie
rs","Catecholamine turnover","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Catalytic receptors","3.2.1.- Glycosidases","Peptidases and proteinases","Other ion channels","ATP-binding cassette tra
nsporter family","Carboxylases and decarboxylases","2.7.1.40 Pyruvate kinases","2.1.1.- Methyltransferases","Voltage-gated ion channels","Transcription factors","Glycoprotein hormone receptors","CYP2 
family: drug metabolising subset",Lipoxygenases,"SLC2 family of hexose and sugar alcohol transporters","Steroid hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","SLC65 NPC-type chole
sterol transporters","Receptor kinases","Adenosine receptors","3B. Estrogen-related receptors",Cyclooxygenase,"Prostaglandin synthases","CYP1 family","MA: Metallo (M) Peptidases","CYP3 family","Chlori
de channels","ABCB subfamily","PB: Threonine (T) Peptidases",Decarboxylases,"CAMK: Calcium/calmodulin-dependent protein kinases","SC: Serine (S) Peptidases","AGC: Containing PKA",PKG,"PKC families","1
F. Retinoic acid-related orphans","SLCO family of organic anion transporting polypeptides","Voltage-gated calcium channels","1H. Liver X receptor-like receptors",CYP11,CYP17,CYP19,"CYP20 and CYP21 fam
ilies","ABCG subfamily","5-Hydroxytryptamine receptors","SLC6 neurotransmitter transporter family",CYP5,"CYP7 and CYP8 families","STAT transcription factors","Transient Receptor Potential channels","C
lass I transporters","3A. Estrogen receptors","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","M49: Dipeptidyl-peptidase III","3C. 3-Ketosteroid receptors",CFTR,"T1: Proteasome
","Death-associated kinase (DAPK) family","S9: Prolyl oligopeptidase","Protein kinase C (PKC) family","Monoamine transporter subfamily","ERK subfamily","Receptor tyrosine kinases (RTKs)","Non-receptor
 tyrosine kinases (nRTKs)","p38 subfamily","Delta subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Abl family","Src family","Syk family","Tec family"}

> <pathway_reactome>
{Metabolism,Disease,"Metabolism of RNA","Developmental Biology","Neuronal System","Signal Transduction","Immune System","Transport of small molecules","Gene expression (Transcription)","Digestion and 
absorption","Cell Cycle",Autophagy,"Cellular responses to external stimuli",Hemostasis,"Programmed Cell Death","DNA Repair","Metabolism of proteins","Vesicle-mediated transport","Biological oxidations
","Infectious disease","Metabolism of non-coding RNA","Nervous system development","Transmission across Chemical Synapses","Metabolism of lipids","Disorders of transmembrane transporters","Intracellul
ar signaling by second messengers","Metabolism of nucleotides","Innate Immune System","Plasma lipoprotein assembly",remodeling,"and clearance","RNA Polymerase II Transcription","Signaling by GPCR",Dig
estion,"Cell Cycle Checkpoints","Signaling by Receptor Tyrosine Kinases",Mitotic,"Metabolism of vitamins and cofactors",Macroautophagy,"Abacavir transport and metabolism","Signaling by Rho GTPases","C
ellular responses to stress","Platelet activation","signaling and aggregation","Metabolism of amino acids and derivatives",Apoptosis,"DNA Double-Strand Break Repair","Peptide hormone metabolism","Memb
rane Trafficking","Metabolism of carbohydrates","Base Excision Repair","Post-translational protein modification","SLC-mediated transmembrane transport","Diseases of signal transduction by growth facto
r receptors and second messengers","Phase I - Functionalization of compounds","Leishmania infection","snRNP Assembly","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Neurotransmitter
 receptors and postsynaptic signal transmission","Biosynthesis of specialized proresolving mediators (SPMs)","Metabolism of steroids","SLC transporter disorders","PIP3 activates AKT signaling","Nucleo
base catabolism","Toll-like Receptor Cascades","Plasma lipoprotein clearance","Generic Transcription Pathway","GPCR downstream signalling","Digestion of dietary carbohydrate","GPCR ligand binding","Fa
tty acid metabolism","G1/S DNA Damage Checkpoints","Signaling by NTRKs","Influenza Infection","M Phase","Metabolism of water-soluble vitamins and cofactors","Selective autophagy","Abacavir transmembra
ne transport","Rho GTPase cycle","Cellular response to hypoxia","Uptake and actions of bacterial toxins","Platelet Aggregation (Plug Formation)","Regulation of mitotic cell cycle","Metabolism of polya
mines","Caspase activation via extrinsic apoptotic signalling pathway","Nonhomologous End-Joining (NHEJ)","Incretin synthesis",secretion,"and inactivation","trans-Golgi Network Vesicle Budding","Gluco
se metabolism","Resolution of Abasic Sites (AP sites)",SUMOylation,"Axon guidance","Cellular hexose transport","Phospholipid metabolism","Signaling by FGFR in disease","HIV Infection","Ethanol oxidati
on","Leishmania parasite growth and survival","Activation of NMDA receptors and postsynaptic events","Cytochrome P450 - arranged by substrate type","Biosynthesis of DPA-derived SPMs","Metabolism of st
eroid hormones","Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)","Amine Oxidase reactions","Negative regulation of the PI3K/AKT network","Purine catabolism","Toll Like Receptor 5 (TLR5
) Cascade","LDL clearance","Transcriptional regulation by RUNX1","G alpha (q) signalling events","Parasite infection","Class A/1 (Rhodopsin-like receptors)","Transcriptional regulation by RUNX2","Arac
hidonic acid metabolism","Biosynthesis of DHA-derived SPMs","p53-Dependent G1/S DNA damage checkpoint","Fatty acyl-CoA biosynthesis","Signaling by NTRK1 (TRKA)","Virus Assembly and Release","Nuclear R
eceptor transcription pathway","Mitotic Metaphase and Anaphase","Vitamins B6 activation to pyridoxal phosphate",Aggrephagy,"RHOBTB GTPase Cycle","Oxygen-dependent proline hydroxylation of Hypoxia-indu
cible Factor Alpha","Uptake and function of anthrax toxins","APC/C-mediated degradation of cell cycle proteins","Regulation of ornithine decarboxylase (ODC)","Caspase activation via Dependence Recepto
rs in the absence of ligand",Synthesis,"and inactivation of Glucagon-like Peptide-1 (GLP-1)","Golgi Associated Vesicle Biogenesis",Glycolysis,"G alpha (i) signalling events","Resolution of AP sites vi
a the multiple-nucleotide patch replacement pathway","Transcriptional regulation by RUNX3","Bile acid and bile salt metabolism","SUMO E3 ligases SUMOylate target proteins","NCAM signaling for neurite 
out-growth","Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)","PI Metabolism","Signaling by FGFR1 in disease","Host Interactions of HIV factors","Netrin-1 signaling","Anti-inflammatory
 response favouring Leishmania parasite infection","Post NMDA receptor activation events",Xenobiotics,"Biosynthesis of DPAn-3 SPMs","Pregnenolone biosynthesis","Biogenic amines are oxidatively deamina
ted to aldehydes by MAOA and MAOB",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","MyD88 cascade initiated on plasma membrane","RUNX1 regulates estrogen receptor mediated transcription","Gastrin-CRE
B signalling pathway via PKC and MAPK","Leishmania phagocytosis","Nucleotide-like (purinergic) receptors","Regulation of RUNX2 expression and activity","Synthesis of Prostaglandins (PG) and Thromboxan
es (TX)","Biosynthesis of D-series resolvins","p53-Dependent G1 DNA Damage Response","Synthesis of very long-chain fatty acyl-CoAs","Estrogen biosynthesis","Signalling to ERKs","Assembly of Viral Comp
onents at the Budding Site","Mitotic Anaphase","Biosynthesis of maresins","RUNX2 regulates bone development","RHOBTB3 ATPase cycle","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic
 proteins","Visual phototransduction","PCNA-Dependent Long Patch Base Excision Repair","RUNX3 Regulates Immune Response and Cell Migration","Recycling of bile acids and salts","SUMOylation of DNA meth
ylation proteins","NCAM1 interactions","SUMOylation of intracellular receptors","Endogenous sterols","Amine ligand-binding receptors","Synthesis of PIPs at the plasma membrane",Eicosanoids,"FGFR1 muta
nt receptor activation","The role of Nef in HIV-1 replication and disease pathogenesis","Role of second messengers in netrin-1 signaling","ADORA2B mediated anti-inflammatory cytokines production","Act
ivation of AMPK downstream of NMDARs","CYP2E1 reactions","Biosynthesis of DPAn-3-derived protectins and resolvins","MAP kinase activation","EGFR Transactivation by Gastrin","FCGR3A-mediated phagocytos
is","Adenosine P1 receptors","Stabilization of p53","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Signalling to RAS","Transport of HA trimer","NA tetramer and M2 tetramer from th
e endoplasmic reticulum to the Golgi Apparatus","Nuclear Envelope (NE) Reassembly","FCGR3A-mediated IL10 synthesis","Biosynthesis of maresin-like SPMs","RUNX2 regulates osteoblast differentiation","AP
C/C:Cdc20 mediated degradation of mitotic proteins","The phototransduction cascade","Serotonin receptors","The canonical retinoid cycle in rods (twilight vision)","Signaling by cytosolic FGFR1 fusion 
mutants","Nef and signal transduction","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","p38MAPK events","Initiation of Nuclear Envelope (NE) Re
formation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",Inactivation,"recovery and regulation of the phototransduction cascade","ERK/MAPK t
argets","Activation of the AP-1 family of transcription factors","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CFTR,ESR1,ESR2,ESRRA,ESRRB,ESRRG,NCOA1,NCOA2,PPARG,PTK2B,TOP2A,TRPC5}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{genistein,446-72-0,446720,Prunetol,"4',5,7-Trihydroxyisoflavone","4',5,7Trihydroxyisoflavone",Genisterin,Genisteol,Sophoricol,"5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one","5,7dihydroxy3(4hydr
oxyphenyl)4Hchromen4one","5,7,4'-Trihydroxyisoflavone","5,7,4'Trihydroxyisoflavone",Bonistein,"Differenol A",5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one,7dihydroxy3(4hydroxyphenyl)chromen4one,T1737
,NSC36586,1110,210296,EI-147,"NSC 36586",Genistein,GENISTEIN}

> <pdid>
PD002146

> <targets>
{EGFR,"Tyrosine Kinases",Apoptosis,Autophagy,"Endogenous Metabolite"}

> <classes>
{Apoptosis,Autophagy,JAK/STAT Signaling,Metabolic Enzyme/Protease,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{5280961}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 30  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -2.6024    2.9967    0.0000 C   0  0
   -3.9001    2.2444    0.0000 N   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -0.0093    6.0025    0.0000 O   0  0
   -2.6078    5.9988    0.0000 N   0  0
   -2.6109    7.4996    0.0000 C   0  0
   -3.9118    8.2481    0.0000 C   0  0
   -3.9149    9.7490    0.0000 C   0  0
   -5.2157   10.4975    0.0000 C   0  0
   -5.2210   11.9975    0.0000 C   0  0
   -6.5226   12.7430    0.0000 C   0  0
   -7.8190   11.9885    0.0000 C   0  0
   -7.8138   10.4885    0.0000 C   0  0
   -6.5122    9.7430    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 C   0  0
   -3.8983   -0.7459    0.0000 C   0  0
   -2.6029   -2.9978    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  3  0
  8 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
  6 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 25 27  1  0
 24 28  2  0
 28  4  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28148

> <plate>
Kinase v5-1

> <well>
M05

> <supplier_cmpd_name>
SU1498

> <ctcr_id>
5523

> <supplier_cmpd_id>
AC-1293

> <smiles>
CC(C)c1cc(C=C(C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O

> <pd_targets>
{KDR,MAPT}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein",Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System","Signaling by Receptor Tyrosine Kinases","Transmission across Chemical Synapses","Signaling by VEGF","Neurotransmitter receptors and postsynaptic signal transm
ission","VEGFA-VEGFR2 Pathway","Activation of NMDA receptors and postsynaptic events","VEGFR2 mediated cell proliferation","Post NMDA receptor activation events","Activation of AMPK downstream of NMDA
Rs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"AG 1498;Tyrphostin SU 1498",CHEMBL1731027,DB-010802,DB010802,FT-0771341,FT0771341,SR-03000001063,SR03000001063,SR-03000001063-1,SR030000010631,Q27164327,T3980,AC-1293,Su1498,SU1498}

> <pdid>
PD018399

> <targets>
{Flk1}

> <classes>
{}

> <pubchem_cids>
{5305}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 15  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  8  1  0
 13 14  2  0
 14  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28149

> <plate>
Kinase v5-1

> <well>
M07

> <supplier_cmpd_name>
ZM 449829

> <ctcr_id>
6521

> <supplier_cmpd_id>
EI-357

> <smiles>
C=CC(=O)c1ccc2ccccc2c1

> <pd_targets>
{THRB,JAK3,EGFR,JAK1,MAPT,RORC,KDM4E,ALDH1A1,ALOX15,FTL,MAPK1,TP53,ALOX12,HPGD,CYP3A4,HSD17B10,REP,PKM,FFP,LEF}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Transcription factor","Epigenetic regulator","Unclassified protein",Kinase,Protease,"Nuclear receptor",Eraser,Oxidoreductase,"Cytochrome P450",Transferase,"Protein K
inase","Cysteine protease","Nuclear hormone receptor subfamily 1","Lysine demethylase","Cytochrome P450 family 3","Metallo protease","TK protein kinase group","Cysteine protease CA clan","Nuclear horm
one receptor subfamily 1 group F","Jumonji domain-containing","CMGC protein kinase group","Cytochrome P450 family 3A","Metallo protease MAE clan","Tyrosine protein kinase JakA family","Tyrosine protei
n kinase EGFR family","Cysteine protease C1A family","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase MAPK family","Cytochrome P450 3A4","Metallo protease M34 family","CMGC
 protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Nuclear hormone receptors","Chromatin modifying enzymes","Eicosanoid turnover","Kinases (EC 2.7.x.x)","Cytochrome P450","Anti-infectiv
e targets","2.7.1.40 Pyruvate kinases","Receptor kinases","1F. Retinoic acid-related orphans","1.14.11.- Histone demethylases",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglan
din synthases","CYP3 family","Viral protein targets","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Coronavirus (CoV) proteins","Non-receptor tyrosine kinases (nRTKs)","Recep
tor tyrosine kinases (RTKs)","ERK subfamily","Janus kinase (JakA) family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Neuronal System","Gene expression (Transcription)",Metabolism,"Vesicle-mediated transport","Cell Cycle",Disease,"Cytokine Signaling in Immune system","Signaling
 by GPCR","Transmission across Chemical Synapses","RNA Polymerase II Transcription","Biological oxidations","Metabolism of lipids","Membrane Trafficking","Innate Immune System","Cell Cycle Checkpoints
","Metabolism of amino acids and derivatives","Infectious disease","Metabolism of carbohydrates","Signaling by Interleukins","GPCR downstream signalling","Interferon Signaling","Neurotransmitter recep
tors and postsynaptic signal transmission","Generic Transcription Pathway","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","trans-Golgi Network V
esicle Budding","Toll-like Receptor Cascades","G1/S DNA Damage Checkpoints","Branched-chain amino acid catabolism","SARS-CoV Infections","Glucose metabolism","Uptake and actions of bacterial toxins","
Interleukin-2 family signaling","G alpha (q) signalling events","Antiviral mechanism by IFN-stimulated genes","Activation of NMDA receptors and postsynaptic events","Transcriptional regulation by RUNX
3","Ethanol oxidation","Biosynthesis of DPA-derived SPMs","Golgi Associated Vesicle Biogenesis","Toll Like Receptor 5 (TLR5) Cascade","p53-Dependent G1/S DNA damage checkpoint","Biosynthesis of DHA-de
rived SPMs","SARS-CoV-2 Infection",Glycolysis,"Uptake and function of anthrax toxins","Interleukin-15 signaling","Gastrin-CREB signalling pathway via PKC and MAPK","ISG15 antiviral mechanism","Post NM
DA receptor activation events","RUNX3 Regulates Immune Response and Cell Migration","Biosynthesis of DPAn-3 SPMs","MyD88 cascade initiated on plasma membrane","p53-Dependent G1 DNA Damage Response","B
iosynthesis of D-series resolvins","Biosynthesis of maresins","SARS-CoV-2 Genome Replication and Transcription","EGFR Transactivation by Gastrin","Activation of AMPK downstream of NMDARs","Biosynthesi
s of DPAn-3-derived protectins and resolvins","MAP kinase activation","Stabilization of p53","Biosynthesis of DPAn-3-derived maresins","Biosynthesis of maresin-like SPMs","Replication of the SARS-CoV-
2 genome","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{"ZM 449829",4452-06-6,4452066,"4452 06 6",1-naphthalen-2-ylprop-2-en-1-one,1naphthalen2ylprop2en1one,"1 naphthalen 2 ylprop 2 en 1 one",1-(2-naphthyl)prop-2-en-1-one,1(2naphthyl)prop2en1one,"1 (2 nap
hthyl)prop 2 en 1 one",1-(2-Naphthalenyl)-2-,1(2Naphthalenyl)2,1366,EI-357}

> <pdid>
PD021917

> <targets>
{JAK3,JAK-3}

> <classes>
{}

> <pubchem_cids>
{3799}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 14  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 C   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -3.9005    5.2525    0.0000 C   0  0
   -3.9014    6.7525    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  2  0
  8 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  3  0
M  END
> <name>
UTKinase_V5

> <id>
28150

> <plate>
Kinase v5-1

> <well>
M09

> <supplier_cmpd_name>
BAY 11-7082

> <ctcr_id>
7710

> <supplier_cmpd_id>
EI-278

> <smiles>
Cc1ccc(cc1)[S](=O)(=O)\C=C\C#N

> <pd_targets>
{ALD,RORC,ALDH1A1,FFP,REP,MAPT,NFKB1,NFKB2,RELA,NLRP3,MTOR}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Other cytosolic protein","Unclassified protein","Nuclear receptor",Oxidoreductase,Transferase,Kinase,"Nuclear hormone receptor subfamily 1","Protein Kinase","Nuclear ho
rmone receptor subfamily 1 group F","Atypical protein kinase group","Nuclear hormone receptor subfamily 1 group F member 3","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamil
y"}

> <pathway_chembl>
{Receptors,"Other protein targets",Enzymes,"Nuclear hormone receptors","Anti-infective targets","Catalytic receptors","Kinases (EC 2.7.x.x)","1F. Retinoic acid-related orphans","Viral protein targets"
,"Pattern recognition receptors",Atypical,"Coronavirus (CoV) proteins","NOD-like receptor family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Metabolism,Disease,"Neuronal System","Immune System","RNA Polymerase II Transcription","Biological oxidations","Infectious disease","Transmission across Chemical Syn
apses","Innate Immune System","Generic Transcription Pathway","Phase I - Functionalization of compounds","SARS-CoV Infections","Neurotransmitter receptors and postsynaptic signal transmission","Toll-l
ike Receptor Cascades","Leishmania infection","Transcriptional regulation by RUNX3","Ethanol oxidation","SARS-CoV-2 Infection","Activation of NMDA receptors and postsynaptic events","Toll Like Recepto
r 5 (TLR5) Cascade","Cell recruitment (pro-inflammatory response)","Transcriptional Regulation by TP53","RUNX3 Regulates Immune Response and Cell Migration","SARS-CoV-2 Genome Replication and Transcri
ption","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","Purinergic signaling in leishmaniasis infection","Regulation of TP53 Activity","Replication of the SARS-CoV-
2 genome","Activation of AMPK downstream of NMDARs","TAK1 activates NFkB by phosphorylation and activation of IKKs complex","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradat
ion"}

> <broad_targets>
{RELA}

> <broad_moa>
{"NFkB pathway inhibitor"}

> <synonyms>
{"AY 11708","bay 11-7082","bay 117082",19542-67-7,19542677,(E)-3-Tosylacrylonitrile,(E)3Tosylacrylonitrile,(E)-3-(p-Toluenesulfonyl)acrylonitrile,(E)3(pToluenesulfonyl)acrylonitrile,"Bay 11-7821","Bay
 117821",BAY-11-7082,BAY117082,BAY11-7082,UNII-4Y5G2A4F6O,UNII4Y5G2A4F6O,(E)-3-(4-Methylphenyl)sulfonylprop-2-enenitrile,(E)3(4Methylphenyl)sulfonylprop2enenitrile,BAY-11-7821,BAY117821,3-(4-methylphe
nylsulfonyl)-2-propenenit,3(4methylphenylsulfonyl)2propenenit,"EMD 196870",EI-278,196870,"BAY 11-7082"}

> <pdid>
PD002682

> <targets>
{"IKK pathway"}

> <classes>
{}

> <pubchem_cids>
{5353431}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
   -5.2649   -4.1084    0.0000 O   0  0
   -4.3533   -5.2996    0.0000 C   0  0
   -2.8675   -5.1069    0.0000 C   0  0
   -2.1519   -3.7886    0.0000 O   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -0.4810   -5.5489    0.0000 C   0  0
    0.8417   -6.2564    0.0000 O   0  0
   -1.8348   -6.1949    0.0000 C   0  0
   -2.1080   -7.6698    0.0000 O   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  3  1  0
  8  9  1  0
  5 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 10  1  0
 20 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28151

> <plate>
Kinase v5-1

> <well>
M11

> <supplier_cmpd_name>
5,6-dichloro-1-?-D-ribofuranosylbenzimidazole

> <ctcr_id>
4295

> <supplier_cmpd_id>
EI-231

> <smiles>
OCC1OC(C(O)C1O)n2cnc3cc(Cl)c(Cl)cc23

> <pd_targets>
{DYRK1A,CSNK2A1,CCNA1,CCNA2,CDK2,CCNT1,CDK9,CSNK2A2,CSNK2B,AMPC}

> <pathway_gtopdb>
{Enzyme,Kinase,Hydrolase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","CMGC protein kinase DYRK family","Other protein kinase CK2 family","CMGC protein kinase CDK family",
"CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK
) family","Other protein kinases","Dyrk1 subfamily","Casein kinase 2 (CK2) family"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Mitotic,"RNA Polymerase II Transcription","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","G0 and Early G1","Transcriptional Regu
lation by TP53","Regulation of TP53 Activity","Regulation of TP53 Activity through Phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{385,53-85-0,53850,DRB;,MLS003171503,"2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol","2(5,6dichlorobenzimidazol1yl)5(hydroxymethyl)oxolane3,4diol",NSC401575,Kinome_3639,Kinome363
9,Kinome-3639,"Kinome 3639",CHEMBL267071,SCHEMBL20419020,HMS3373F12,NSC-401575,N-(3-chloropropyl)piperidinehydrochloride,N(3chloropropyl)piperidinehydrochloride,NCGC00096104-01,NCGC0009610401,NCGC0009
6104-02,NCGC0009610402,SMR0,EI-231,"5,6-dichloro-1-?-D-ribofuranosylbenzimidazole"}

> <pdid>
PD004368

> <targets>
{"CK II"}

> <classes>
{}

> <pubchem_cids>
{3165}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 25  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 O   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -2.5981   -3.0050    0.0000 O   0  0
   -1.2955   -5.2529    0.0000 C   0  0
   -2.5933   -6.0050    0.0000 O   0  0
    0.0048   -6.0009    0.0000 C   0  0
    0.0072   -7.5009    0.0000 O   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
    2.6004   -2.9990    0.0000 C   0  0
    3.9002   -3.7493    0.0000 O   0  0
    5.1996   -3.0000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  9  1  0
  8 10  1  0
 10 11  1  0
 10 12  2  0
 12  4  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 16 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 13  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28152

> <plate>
Kinase v5-1

> <well>
M13

> <supplier_cmpd_name>
2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether

> <ctcr_id>
89

> <supplier_cmpd_id>
EI-273

> <smiles>
COCc1cc(O)c(O)c(O)c1c2c(O)c(O)c(O)cc2COC

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{hbdde,154675-18-0,154675180,"154675 18 0",CHEMBL59451,"2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether","2,2',3,3',4,4'Hexahydroxy1,1'biphenyl6,6'dimethanol dimethyl ether",2,
2',3,3',4,"4' Hexahydroxy 1","1' biphenyl 6","6' dimet",EI-273}

> <pdid>

> <targets>
{"PKC alpha","PKC gamma"}

> <classes>
{}

> <pubchem_cids>
{3568}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 20  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.1471   -2.9705    0.0000 N   0  0
   -4.6471   -2.9705    0.0000 N   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  7  1  0
 15 10  1  0
 14 16  1  0
 16  4  1  0
 16 17  2  0
M  END
> <name>
UTKinase_V5

> <id>
28153

> <plate>
Kinase v5-1

> <well>
M15

> <supplier_cmpd_name>
SP 600125

> <ctcr_id>
11925

> <supplier_cmpd_id>
EI-305

> <smiles>
c1ccc2c(c1)c1n[nH]c3cccc(c13)c2=O

> <pd_targets>
{MAPK10,MAPK9,MAPK8,EIF2AK2,TTK,JAK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","TK protein kinase group","CMGC protein kinase MAPK family","Other protein kinase PEK family","Other protein ki
nase TTK family","Tyrosine protein kinase JakA family","CMGC protein kinase JNK subfamily","Other protein kinase PKR"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Mitogen-activated protein kinases (MAP kinases)","Other protein kina
ses","TK: Tyrosine kinase","JNK subfamily","PEK family","TTK family","Non-receptor tyrosine kinases (nRTKs)","Other PEK family kinases","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Immune System",Disease,"Innate Immune System","Infectious disease","Cytokine Signaling in Immune system","Toll-like Receptor Cascades","Influenza Infection","Signaling by Interleukins","Toll Like Re
ceptor 5 (TLR5) Cascade","NS1 Mediated Effects on Host Pathways","Interleukin-2 family signaling","MyD88 cascade initiated on plasma membrane","Inhibition of PKR","Interleukin-15 signaling","MAP kinas
e activation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{129-56-6,129566,"1,9-Pyrazoloanthrone","1,9Pyrazoloanthrone",SP600125,Pyrazolanthrone,"Dibenzo(cd,g)indazol-6(2H)-one","Dibenzo(cd,g)indazol6(2H)one",Pyrazoleanthrone,"SP 600125","Anthra(1,9-cd)pyraz
ol-6(2H)-one","Anthra(1,9cd)pyrazol6(2H)one",SP-600125,"Anthra-1,9-pyrazol-6-none","Anthra1,9pyrazol6none","JNK Inhibitor II",2H-Dibenzo(cd,2HDibenzo(cd,g)indazol-6-on,g)indazol6on,T3109}

> <pdid>
PD002737

> <targets>
{JNK,"Aurora A",JNK1,JNK2,JNK3,TrkA}

> <classes>
{"Cell Cycle/Checkpoint",MAPK,"Tyrosine Kinase/Adaptors",Chromatin/Epigenetic}

> <pubchem_cids>
{8515}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 23  0  0  0  0            999 V2000
    2.5532   -4.4223    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -0.2491   -5.5022    0.0000 N   0  0
   -1.4850   -6.3508    0.0000 C   0  0
   -1.6812   -7.8379    0.0000 C   0  0
   -3.0671   -8.4116    0.0000 C   0  0
   -4.2569   -7.4981    0.0000 C   0  0
   -4.0607   -6.0110    0.0000 C   0  0
   -2.6748   -5.4373    0.0000 C   0  0
   -2.1742   -4.0242    0.0000 C   0  0
   -3.0159   -2.7826    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10  2  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 11  1  0
 19 20  2  0
M  END
> <name>
UTKinase_V5

> <id>
28154

> <plate>
Kinase v5-1

> <well>
M17

> <supplier_cmpd_name>
Indirubin

> <ctcr_id>
7712

> <supplier_cmpd_id>
CC-206

> <smiles>
O=C/1Nc2ccccc2C1=C/3Nc4ccccc4C3=O

> <pd_targets>
{SRC,SMN1,CCNA2,CDK2,CDC42,RAC1,GSK3B,CDK5,CDK5R1,GSK3A,PYK,MAPT,RAB9A,MAPK1,CDK1,CCND1,CDK4,RAB7A,CTRB1,RAB2A,CCNE1,KMT2A,MEN1,CCNB1,CCNB2,CCNB3,CDK10,CDK11B,CDK12,CDK13,CDK14,CDK15,CDK16,CDK17,CDK18
,CDK19,CDK20,CDK3,CDK6,CDK7,CDK8,CDK9,CYP1A1,AHR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Transcription factor",Kinase,Reader,Hydrolase,Transferase,Protease,"Cytochrome P450","Protein Kinase","Methyl-lysine/arginine binding protein"
,"Serine protease",Bromodomain,"Cytochrome P450 family 1","TK protein kinase group","Tudor domain","CMGC protein kinase group","Serine protease PA clan","Cytochrome P450 family 1A","Tyrosine protein k
inase Src family","CMGC protein kinase CDK family","CMGC protein kinase GSK family","CMGC protein kinase MAPK family","Serine protease S1A subfamily","Cytochrome P450 1A1","CMGC protein kinase CDC2 su
bfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","Aryl hydrocarbon receptor","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families"
,"CYP1 family","TK: Tyrosine kinase","Glycogen synthase kinase (GSK) family","Mitogen-activated protein kinases (MAP kinases)","Cyclin-dependent kinase (CDK) family","Non-receptor tyrosine kinases (nR
TKs)","GSK subfamily","ERK subfamily","CDK1 subfamily","Src family"}

> <pathway_reactome>
{"Signal Transduction","Metabolism of RNA",Disease,"Developmental Biology","Neuronal System","Immune System","Cell Cycle","Gene expression (Transcription)",Metabolism,"Signaling by Receptor Tyrosine K
inases","Metabolism of non-coding RNA","Infectious disease","Nervous system development","Transmission across Chemical Synapses","Signaling by Rho GTPases","Innate Immune System",Mitotic,"RNA Polymera
se II Transcription","Metabolism of vitamins and cofactors","Biological oxidations","Signaling by NTRKs","snRNP Assembly","Leishmania infection","Axon guidance","SARS-CoV Infections","Neurotransmitter
 receptors and postsynaptic signal transmission","Rho GTPase cycle","Toll-like Receptor Cascades","Regulation of mitotic cell cycle","Infection with Mycobacterium tuberculosis","Generic Transcription 
Pathway","Metabolism of water-soluble vitamins and cofactors","M Phase","Phase I - Functionalization of compounds","Signaling by NTRK1 (TRKA)","Parasite infection","Semaphorin interactions","SARS-CoV-
1 Infection","Activation of NMDA receptors and postsynaptic events","RHOBTB GTPase Cycle","Toll Like Receptor 5 (TLR5) Cascade","APC/C-mediated degradation of cell cycle proteins","Response of Mtb to 
phagocytosis","Transcriptional Regulation by TP53","Cobalamin (Cbl","vitamin B12) transport and metabolism","Mitotic Prophase","Cytochrome P450 - arranged by substrate type","Signalling to ERKs","Leis
hmania phagocytosis","Sema4D in semaphorin signaling","SARS-CoV-1 Genome Replication and Transcription","Post NMDA receptor activation events","RHOBTB3 ATPase cycle","MyD88 cascade initiated on plasma
 membrane","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Suppression of phagosomal maturation","Regulation of TP53 Activity","Golgi Cisternae Pericentriolar Stack Reo
rganization",Xenobiotics,"Endogenous sterols","Signalling to RAS","FCGR3A-mediated phagocytosis","Sema4D mediated inhibition of cell attachment and migration","Replication of the SARS-CoV-1 genome","A
ctivation of AMPK downstream of NMDARs","MAP kinase activation","APC/C:Cdc20 mediated degradation of mitotic proteins","Prevention of phagosomal-lysosomal fusion","Regulation of TP53 Expression and De
gradation","p38MAPK events","MAPK targets/ Nuclear events mediated by MAP kinases","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Regulation
 of TP53 Degradation","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CDK1,CDK5,GSK3A}

> <broad_moa>
{"CDK inhibitor","glycogen synthase kinase inhibitor"}

> <synonyms>
{Indirubin,CC-206}

> <pdid>
PD010731

> <targets>
{GSK-3,Apoptosis}

> <classes>
{Apoptosis}

> <pubchem_cids>
{5318433}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 O   0  0
   -0.6890   -4.0818    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.0059   -1.5004    0.0000 C   0  0
    1.2903   -0.7456    0.0000 N   0  0
    2.4080   -1.7447    0.0000 C   0  0
    3.8992   -1.5823    0.0000 C   0  0
    4.7854   -2.7925    0.0000 C   0  0
    4.1805   -4.1651    0.0000 C   0  0
    2.6893   -4.3275    0.0000 C   0  0
    1.8030   -3.1173    0.0000 C   0  0
   -1.3792   -0.8952    0.0000 C   0  0
   -1.5574    0.5823    0.0000 C   0  0
   -0.4658    1.6111    0.0000 O   0  0
   -3.0334    0.8495    0.0000 N   0  0
   -3.7430   -0.4711    0.0000 C   0  0
   -5.2001   -0.8273    0.0000 C   0  0
   -5.6202   -2.2673    0.0000 C   0  0
   -4.5831   -3.3511    0.0000 C   0  0
   -3.1261   -2.9949    0.0000 C   0  0
   -2.7060   -1.5549    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  3  1  0
 11  6  1  0
  4 12  2  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 12  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28155

> <plate>
Kinase v5-1

> <well>
M19

> <supplier_cmpd_name>
Indirubin-3'-monooxime

> <ctcr_id>
7713

> <supplier_cmpd_id>
CC-207

> <smiles>
O/N=C1/C(Nc2ccccc12)=C3/C(=O)Nc4ccccc34

> <pd_targets>
{IGF1R,GSK3B,STK17B,CDK5,CDK1,CDK2,AHR,RAC1,CDC42,RAB2A,RAB7A}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,Hydrolase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","CAMK protein kinase group","Tyrosine protein kinase InsR family","CMGC protein k
inase GSK family","CAMK protein kinase DAPK family","CMGC protein kinase CDK family","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Aryl hydrocarbon receptor","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/ca
lmodulin-dependent protein kinases","TK: Tyrosine kinase","Glycogen synthase kinase (GSK) family","Death-associated kinase (DAPK) family","Cyclin-dependent kinase (CDK) family","Receptor tyrosine kina
ses (RTKs)","GSK subfamily","CDK5 subfamily","CDK1 subfamily","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Gene expression (Transcription)","Cell Cycle",Metabolism,"Developmental Biology","Signaling by Receptor Tyrosine Kinases","Infectious disease","RNA Polymerase II Transc
ription",Mitotic,"Biological oxidations","Nervous system development","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","SARS-CoV Infections","Generic Transcription Pathway","Regulat
ion of mitotic cell cycle","Phase I - Functionalization of compounds","Axon guidance","Leishmania infection","M Phase","Infection with Mycobacterium tuberculosis","IGF1R signaling cascade","SARS-CoV-1
 Infection","Transcriptional Regulation by TP53","APC/C-mediated degradation of cell cycle proteins","Cytochrome P450 - arranged by substrate type","Semaphorin interactions","Parasite infection","Mito
tic Prophase","Response of Mtb to phagocytosis","IRS-related events triggered by IGF1R","SARS-CoV-1 Genome Replication and Transcription","Regulation of TP53 Activity","Activation of APC/C and APC/C:C
dc20 mediated degradation of mitotic proteins","Endogenous sterols","Sema4D in semaphorin signaling","Leishmania phagocytosis","Golgi Cisternae Pericentriolar Stack Reorganization","Suppression of pha
gosomal maturation","Replication of the SARS-CoV-1 genome","Regulation of TP53 Activity through Phosphorylation","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Expression a
nd Degradation","Sema4D mediated inhibition of cell attachment and migration","FCGR3A-mediated phagocytosis","Prevention of phagosomal-lysosomal fusion","APC:Cdc20 mediated degradation of cell cycle p
roteins prior to satisfation of the cell cycle checkpoint","Regulation of TP53 Degradation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{CDK1,CDK2,CDK5,CDK5R1,GSK3B}

> <broad_moa>
{"CDK inhibitor","glycogen synthase kinase inhibitor"}

> <synonyms>
{NDIRUBIN3'MONOXIM,INDIRUBIN-3'-MONOXIME,INDIRUBIN3'MONOXIME,indirubin-3'-oxime,indirubin3'oxime,160807-49-8,160807498,Indirubin-3-monoxime,Indirubin3monoxime,indirubin-3-oxime,indirubin3oxime,Indirub
in-3monoxime,3-(3-(Hydroxyamino)-1H-indol-2-yl)indol-2-one,3(3(Hydroxyamino)1Hindol2yl)indol2one,CHEBI:43645,"Indirubin 3'-monoxime","Indirubin 3'monoxime",indirubin-3'-monooxime,indirubin3'monooxime,
(Z)-1H,(Z)1H,1'H-(2,1'H(2,3,"EMD 402085",CC-207,402085,Indirubin-3'-monooxime}

> <pdid>
PD002811

> <targets>
{GSK-3beta}

> <classes>
{}

> <pubchem_cids>
{3707}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -5.1072    0.0000    0.0000 C   0  0
   -5.8659   -1.2803    0.0000 O   0  0
   -7.3243   -0.9298    0.0000 C   0  0
   -8.4618   -1.9049    0.0000 C   0  0
   -8.1867   -3.3795    0.0000 O   0  0
   -7.4417    0.5656    0.0000 C   0  0
   -8.7205    1.3496    0.0000 O   0  0
   -6.0557    1.1393    0.0000 C   0  0
   -5.6962    2.5956    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -2.8161   -2.7592    0.0000 N   0  0
   -1.6025   -3.6408    0.0000 C   0  0
   -0.2322   -3.0307    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  4  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 11 14  1  0
 14 15  1  0
 14 16  1  0
 16  9  1  0
 16 17  1  0
  8 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22  2  1  0
 22 23  2  0
 23  6  1  0
 23 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28157

> <plate>
Kinase v5-1

> <well>
O03

> <supplier_cmpd_name>
Triciribine

> <ctcr_id>
1508

> <supplier_cmpd_id>
EI-332

> <smiles>
CN1N=C(N)c2cn(C3OC(CO)C(O)C3O)c4ncnc1c24

> <pd_targets>
{POL}

> <pathway_gtopdb>
{Enzyme,Hydrolase}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
{AKT1,AKT2,AKT3}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{NSC154020,MLS002702033,"API-2;NSC 154020;TCN","API2;NSC 154020;TCN","Akt/PKB Signaling Inhibitor-2","Akt/PKB Signaling Inhibitor2",NSC-154020,TCN,"Akt Inhibitor V, Triciribine","Akt inhibitor V","tri
cyclic nucleoside (TCN)",SCHEMBL61269,GTPL5920,CHEMBL1892348,CHEBI:91697,HMS3229A09,HMS3268N05,HMS3,T6065,"EMD 124012",EI-332,2151,"NSC 154020",Triciribine,124012,API-2}

> <pdid>
PD011889

> <targets>
{PKB,"Akt signaling pathway",Akt,"DNA/RNA Synthesis",HIV}

> <classes>
{Anti-infection,Cell Cycle/DNA Damage,PI3K/Akt/mTOR}

> <pubchem_cids>
{290486}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    2.5951   -3.0031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -6.4995    3.7483    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -6.4948    0.7483    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1968   -1.5004    0.0000 C   0  0
   -6.4971   -0.7525    0.0000 C   0  0
   -7.7950   -1.5046    0.0000 C   0  0
   -7.7926   -3.0046    0.0000 C   0  0
   -6.4923   -3.7525    0.0000 C   0  0
   -5.1945   -3.0005    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
  9 16  1  0
 16 17  2  0
 17 18  1  0
 18  7  1  0
 18 19  2  0
 19  4  1  0
 16 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28158

> <plate>
Kinase v5-1

> <well>
O05

> <supplier_cmpd_name>
BML-257

> <ctcr_id>
4089

> <supplier_cmpd_id>
EI-336

> <smiles>
OC(=O)c1ccc2nc(c3ccccc3)c(nc2c1)c4ccccc4

> <pd_targets>
{RORC,RAB9A,ALDH1A1,GAA,HPGD,KDM4E,NPC1,SMN1}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator",Transporter,"Nuclear receptor",Hydrolase,Oxidoreductase,Eraser,Reader,"Nuclear hormone receptor subfamily 1","Lysine demethylase","Methyl-lysine/a
rginine binding protein","Nuclear hormone receptor subfamily 1 group F","Jumonji domain-containing","Tudor domain","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Nuclear hormone receptors","3.2.1.- Glycosidases","Eicosanoid turnover","Chromatin modifying enzymes","SLC superfamily of solute carriers","1F. Retinoic acid-related o
rphans","Prostaglandin synthases","1.14.11.- Histone demethylases","SLC65 NPC-type cholesterol transporters"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction",Metabolism,Disease,"Transport of small molecules","Metabolism of RNA","RNA Polymerase II Transcription","Signaling by Rho GTPases","Biological 
oxidations","Diseases of metabolism","Metabolism of lipids","Plasma lipoprotein assembly",remodeling,"and clearance","Metabolism of non-coding RNA","Generic Transcription Pathway","Rho GTPase cycle","
Phase I - Functionalization of compounds","Diseases of carbohydrate metabolism","Biosynthesis of specialized proresolving mediators (SPMs)","Plasma lipoprotein clearance","snRNP Assembly","Transcripti
onal regulation by RUNX3","RHOBTB GTPase Cycle","Ethanol oxidation","Glycogen storage diseases","Biosynthesis of DHA-derived SPMs","LDL clearance","RUNX3 Regulates Immune Response and Cell Migration",
"RHOBTB3 ATPase cycle","Glycogen storage disease type II (GAA)","Biosynthesis of D-series resolvins"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ML25,"ML 25","2,3-diphenylquinoxaline-6-carboxylic acid","2,3diphenylquinoxaline6carboxylic acid","2,3 diphenylquinoxaline 6 carboxylic acid",32387-96-5,32387965,"32387 96 5","2,3-Diphenyl-quinoxalin
e-6-carboxylic acid","2,3Diphenylquinoxaline6carboxylic acid",2,3Diphenylquinoxaline6car,EI-336,BML-257}

> <pdid>
PD019585

> <targets>
{Akt}

> <classes>
{}

> <pubchem_cids>
{629852}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 15  0  0  0  0            999 V2000
    1.0255   -3.6140    0.0000 N   0  0
    1.6332   -2.2426    0.0000 C   0  0
    3.1247   -2.0836    0.0000 O   0  0
    0.7500   -1.0323    0.0000 C   0  0
    1.2135    0.3943    0.0000 S   0  0
    0.0000    1.2760    0.0000 C   0  0
   -1.2135    0.3943    0.0000 C   0  0
   -0.7500   -1.0323    0.0000 C   0  0
   -1.6317   -2.2458    0.0000 N   0  0
    0.0000    2.7767    0.0000 C   0  0
    1.1393    3.7252    0.0000 C   0  0
    0.5656    5.1112    0.0000 S   0  0
   -0.9298    4.9939    0.0000 C   0  0
   -1.2803    3.5354    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  4  2  0
  8  9  1  0
  6 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28159

> <plate>
Kinase v5-1

> <well>
O07

> <supplier_cmpd_name>
SC-514

> <ctcr_id>
1461

> <supplier_cmpd_id>
EI-343

> <smiles>
NC(=O)c1sc(cc1N)c2cscc2

> <pd_targets>
{MAPT,IKBKB,ALDH1A1}

> <pathway_gtopdb>
{"Other cytosolic protein",Enzyme,Kinase,Oxidoreductase,"Protein Kinase","Other protein kinase group","Other protein kinase IKK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","IKK family"}

> <pathway_reactome>
{"Neuronal System","Immune System",Metabolism,"Transmission across Chemical Synapses","Innate Immune System","Biological oxidations","Neurotransmitter receptors and postsynaptic signal transmission","
Toll-like Receptor Cascades","Phase I - Functionalization of compounds","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 4 (TLR4) Cascade","Ethanol oxidation","Post NMDA rece
ptor activation events","MyD88-independent TLR4 cascade","Activation of AMPK downstream of NMDARs","TRIF(TICAM1)-mediated TLR4 signaling","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor","SYK inhibitor"}

> <synonyms>
{C51,SC-514,SC514,354812-17-2,354812172,"Sc 514","4-Amino-(2,3'-bithiophene)-5-carboxamide","4Amino(2,3'bithiophene)5carboxamide",3-amino-5-thiophen-3-ylthiophene-2-carboxamide,3amino5thiophen3ylthiop
hene2carboxamide,3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide,3amino5(thiophen3yl)thiophene2carboxamide,CHEMBL193093,3-amino-5-(3-thienyl)thiophene-2-carboxamide,3amino5(3thienyl)thiophene2carboxa
mide,3-amino-5-(3-thio,3amino5(3thio,T2118,3318,EI-343,S4907,"SC 514"}

> <pdid>
PD010663

> <targets>
{IKK,I??B/IKK,I?B/IKK,IKK2}

> <classes>
{NF-?B}

> <pubchem_cids>
{2807869}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    4.8903  -10.1311    0.0000 C   0  0
    5.5071   -8.7638    0.0000 C   0  0
    6.9997   -8.6148    0.0000 C   0  0
    4.6332   -7.5468    0.0000 C   0  0
    5.1017   -6.1218    0.0000 S   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.6747   -6.1134    0.0000 N   0  0
    3.1332   -7.5416    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
  6 17  2  0
 17 18  1  0
 18  4  2  0
M  END
> <name>
UTKinase_V5

> <id>
28160

> <plate>
Kinase v5-1

> <well>
O09

> <supplier_cmpd_name>
BML-259

> <ctcr_id>
3500

> <supplier_cmpd_id>
EI-344

> <smiles>
CC(C)c1sc(NC(=O)Cc2ccccc2)nc1

> <pd_targets>
{FTL,SMN1,CCNE1,CDK2,CCNA2,CDK5,CCNH,CDK7,MNAT1,CDK5R1,CCNT1,CDK9,CCNB1,CDK1,CCND1,CDK4}

> <pathway_gtopdb>
{"Unclassified protein","Epigenetic regulator",Enzyme,Reader,Kinase,"Methyl-lysine/arginine binding protein","Protein Kinase","Tudor domain","CMGC protein kinase group","CMGC protein kinase CDK family
","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK5 subfamily"}

> <pathway_reactome>
{"Vesicle-mediated transport","Metabolism of RNA","Gene expression (Transcription)","Membrane Trafficking","Metabolism of non-coding RNA","RNA Polymerase II Transcription","trans-Golgi Network Vesicle
 Budding","snRNP Assembly","Generic Transcription Pathway","Golgi Associated Vesicle Biogenesis","Transcriptional Regulation by TP53","Regulation of TP53 Activity","Regulation of TP53 Activity through
 Phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ML25,267654-00-2,267654002,BML-259,BML259,2-phenyl-N-(5-propan-2-yl-2-thiazolyl)acetamide,2phenylN(5propan2yl2thiazolyl)acetamide,"2-phenyl-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide","2phenylN(5pro
pan2yl1,3thiazol2yl)acetamide",CHEMBL426972,"BML 259",N-(5-(1-Methylethyl)-2-thiazolyl)benzeneacetamide,N(5(1Methylethyl)2thiazolyl)benzeneacetamide,N-(5-Isopropyl-1,N(5Isopropyl1,3-thiazol-2-yl)-2-ph
enylacetamide,3thiazol2yl)2phenylacetamide,EI-344}

> <pdid>
PD020218

> <targets>
{Cdk5/p25}

> <classes>
{}

> <pubchem_cids>
{16760027}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 12  1  0
 19 20  1  0
 20  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28161

> <plate>
Kinase v5-1

> <well>
O11

> <supplier_cmpd_name>
Apigenin

> <ctcr_id>
1229

> <supplier_cmpd_id>
EI-345

> <smiles>
Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2

> <pd_targets>
{THPO,KMT2A,MEN1,LMNA,NFKB1,HBB,CYP2C19,NFO,HIF1A,ALOX15,HPGD,CYP2D6,CYP3A4,GMNN,ABCB1,POL,GUSB,CSNK2A1,SYK,PIM1,MAPK10,LPO,ADORA2A,MAOB,TSHR,CYP1B1,XDH,PTGS2,ELANE,GABRA1,GABRA2,GABRA3,GABRA4,GABRA5,
GABRA6,GABRB1,GABRB2,GABRB3,GABRD,GABRE,GABRG1,GABRG2,GABRG3,GABRP,GABRQ,NANH,GSK3B,IP6K2,TNKS,MYOC,FFP,MAOA,DPP3,EGFR,CYP19A1,TTR,NLRP3,CYP1A2,KDM4E,ALDH1A1,BACE1,ESR2,NA,HSD17B10,SMN1,TDP1,MAPT,PARP
1,CFTR,DPP4,CDK6,AKR1B1,ADORA1,LYZ1,ESR1,CDK5,CDK5R1,GSK3A,FABI,MAPK14,HSD17B3,AURKB,CA4,MPO,MUC1,DAPK1,CSNK2A2,CSNK2A3,CSNK2B,PYK,PMP22,APEX1,IPMK,TNKS2,BCHE,FLT3,CCNB1,CCNB2,CCNB3,CDK1,CYP1A1,THRB,N
PC1,IMPA1,APP,ACHE,CA2,CA3,CA1,RORC,GNAI1,RGS12,CYP2C9,PFMRK,MAPK1,NKX2-5,REP,PKM,ALD,NPSR1,LCK,AR,HSD17B1,AKR1B10,PSMB5,ABCG2,ABCC1,GATA4,NOX4,PPARG}

> <pathway_gtopdb>
{"Unclassified protein","Epigenetic regulator","Other nuclear protein","Other cytosolic protein","Secreted protein",Enzyme,"Transcription factor",Transporter,"Membrane receptor","Ion channel",Reader,"
Cytochrome P450",Hydrolase,Oxidoreductase,"Primary active transporter",Kinase,"Family A G protein-coupled receptor",Protease,"Ligand-gated ion channel",Transferase,Eraser,"Nuclear receptor","Other ion
 channel",Lyase,Bromodomain,"Cytochrome P450 family 2","Cytochrome P450 family 3","ATP-binding cassette","Protein Kinase","Small molecule receptor (family A GPCR)","Peptide receptor (family A GPCR)","
Cytochrome P450 family 1","Serine protease","GABA-A receptor","Metallo protease","Cytochrome P450 family 19","Lysine demethylase","Aspartic protease","Nuclear hormone receptor subfamily 3","Methyl-lys
ine/arginine binding protein","Chloride channel","Nuclear hormone receptor subfamily 1","Cysteine protease","Threonine protease","Cytochrome P450 family 2C","Cytochrome P450 family 2D","Cytochrome P45
0 family 3A","ABCB subfamily","Other protein kinase group","TK protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Nucleotide-like receptor (family A GPCR)","Glycohormone re
ceptor","Cytochrome P450 family 1B","Serine protease PA clan","Metallo protease MAE clan","Cytochrome P450 family 19A","Cytochrome P450 family 1A","Jumonji domain-containing","Aspartic protease AA cla
n","Nuclear hormone receptor subfamily 3 group A","Tudor domain","Cystic fibrosis transmembrane conductance regulator","Serine protease SC clan","Nuclear hormone receptor subfamily 1 group A","Cystein
e protease CA clan","Nuclear hormone receptor subfamily 1 group F","Short peptide receptor (family A GPCR)","Nuclear hormone receptor subfamily 3 group C","Threonine protease PBT clan","ABCG subfamily
","ABCC subfamily","Nuclear hormone receptor subfamily 1 group C","Cytochrome P450 2C19","Cytochrome P450 2D6","Cytochrome P450 3A4","Other protein kinase CK2 family","Tyrosine protein kinase Syk fami
ly","CAMK protein kinase PIM family","CMGC protein kinase MAPK family","Adenosine receptor","Cytochrome P450 1B1","Serine protease S1A subfamily","CMGC protein kinase GSK family","Metallo protease M49
 family","Tyrosine protein kinase EGFR family","Cytochrome P450 19A1","Cytochrome P450 1A1","Aspartic protease A1A subfamily","Nuclear hormone receptor subfamily 3 group A member 2","Serine protease S
9B subfamily","Nuclear hormone receptor subfamily 3 group A member 1","CMGC protein kinase CDK family","Other protein kinase AUR family","CAMK protein kinase DAPK family","Tyrosine protein kinase PDGF
R family","Nuclear hormone receptor subfamily 1 group A member 2","Cysteine protease C1A family","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 2C9","Neuropeptide receptor","
Tyrosine protein kinase Src family","Nuclear hormone receptor subfamily 3 group C member 4","Threonine protease T1A subfamily","Nuclear hormone receptor subfamily 1 group C member 3","CMGC protein kin
ase JNK subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Transporters,Receptors,"Other protein targets","Ion channels","Cytochrome P450","Eicosanoid turnover","ATP-binding cassette transporter family","Catalytic receptors","Kinases (EC 2.7.x.x)","G
 protein-coupled receptors","Catecholamine turnover","1.-.-.- Oxidoreductases","Peptidases and proteinases","Poly ADP-ribose polymerases",Transthyretin,"Chromatin modifying enzymes","Nuclear hormone r
eceptors","Other ion channels","Carbonic anhydrases","Acetylcholine turnover","SLC superfamily of solute carriers","Inositol phosphate turnover","Anti-infective targets","2.7.1.40 Pyruvate kinases","N
ADPH oxidases","CYP2 family: drug metabolising subset",Lipoxygenases,"Prostaglandin synthases","CYP3 family","ABCB subfamily","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","C
MGC: Containing CDK",MAPK,GSK3,"CLK families","Adenosine receptors","Glycoprotein hormone receptors","CYP1 family",Cyclooxygenase,"PA: Serine (S) Peptidases","MA: Metallo (M) Peptidases",CYP11,CYP17,C
YP19,"CYP20 and CYP21 families","Pattern recognition receptors","1.14.11.- Histone demethylases","AA: Aspartic (A) Peptidases","Steroid hormone receptors","Chloride channels","SC: Serine (S) Peptidase
s","1A. Thyroid hormone receptors","SLC65 NPC-type cholesterol transporters","Inositol monophosphatase","1F. Retinoic acid-related orphans","Viral protein targets","Neuropeptide S receptor","PB: Threo
nine (T) Peptidases","ABCG subfamily","ABCC subfamily","1C. Peroxisome proliferator-activated receptors","Other protein kinases","TK: Tyrosine kinase","PIM family","Mitogen-activated protein kinases (
MAP kinases)","S1: Chymotrypsin","Glycogen synthase kinase (GSK) family","M49: Dipeptidyl-peptidase III","NOD-like receptor family","A1: Pepsin","3A. Estrogen receptors",CFTR,"S9: Prolyl oligopeptidas
e","Cyclin-dependent kinase (CDK) family","Death-associated kinase (DAPK) family","Coronavirus (CoV) proteins","3C. 3-Ketosteroid receptors","T1: Proteasome","Casein kinase 2 (CK2) family","Non-recept
or tyrosine kinases (nRTKs)","JNK subfamily","GSK subfamily","Receptor tyrosine kinases (RTKs)","CDK4 subfamily","p38 subfamily","Aurora kinase (Aur) family","ERK subfamily","Syk family","Type I RTKs:
 ErbB (epidermal growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Src family"}

> <pathway_reactome>
{Hemostasis,"Cell Cycle","Immune System",Metabolism,"Cellular responses to external stimuli",Disease,"Gene expression (Transcription)","Signal Transduction","Metabolism of proteins","Metabolism of RNA
","DNA Repair","Neuronal System",Autophagy,"Transport of small molecules","Programmed Cell Death","Developmental Biology","Platelet activation","signaling and aggregation",Mitotic,"Cytokine Signaling 
in Immune system","Innate Immune System","Biological oxidations","Cellular responses to stress","Metabolism of lipids","Abacavir transport and metabolism","Diseases of metabolism","RNA Polymerase II T
ranscription","Infectious disease","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of nucleotides","Intracellular signaling by second messengers","Signal
ing by GPCR","Amyloid fiber formation","Metabolism of amino acids and derivatives","Metabolism of non-coding RNA","DNA Double-Strand Break Repair","Transmission across Chemical Synapses",Macroautophag
y,"Peptide hormone metabolism","O2/CO2 exchange in erythrocytes",Apoptosis,"Nervous system development","Base Excision Repair","Inositol phosphate metabolism","Signaling by Receptor Tyrosine Kinases",
"Post-translational protein modification","Plasma lipoprotein assembly",remodeling,"and clearance","Reversible hydration of carbon dioxide","Metabolism of carbohydrates","Metabolism of vitamins and co
factors","Platelet Aggregation (Plug Formation)","M Phase","Signaling by Interleukins","Neutrophil degranulation","Phase I - Functionalization of compounds","Cellular response to hypoxia","Biosynthesi
s of specialized proresolving mediators (SPMs)","Mitotic G1 phase and G1/S transition","Abacavir transmembrane transport","Diseases of carbohydrate metabolism","Generic Transcription Pathway","Leishma
nia infection","FLT3 signaling in disease","Toll-like Receptor Cascades","ROS and RNS production in phagocytes","Nucleobase catabolism","Complement cascade","SARS-CoV Infections","Interferon Signaling
","PIP3 activates AKT signaling","GPCR downstream signalling","Influenza Infection","Branched-chain amino acid catabolism","snRNP Assembly","Nonhomologous End-Joining (NHEJ)","Neurotransmitter recepto
rs and postsynaptic signal transmission","Selective autophagy","Incretin synthesis",secretion,"and inactivation","Metabolism of steroids","GPCR ligand binding","Fatty acid metabolism","Erythrocytes ta
ke up carbon dioxide and release oxygen","Diseases of glycosylation","Caspase activation via extrinsic apoptotic signalling pathway","EGR2 and SOX10-mediated initiation of Schwann cell myelination","R
esolution of Abasic Sites (AP sites)","Synthesis of IPs in the nucleus","Phospholipid metabolism","Signaling by Insulin receptor",SUMOylation,"Plasma lipoprotein clearance","Synthesis of IP2",IP,"and 
Ins in the cytosol","Glucose metabolism","HIV Infection","Metabolism of fat-soluble vitamins","Regulation of mitotic cell cycle","Mitotic Metaphase and Anaphase","Interleukin-1 family signaling","Cyto
chrome P450 - arranged by substrate type","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Biosynthesis of DPA-derived SPMs","Biosynthesis of DHA-derived SPMs","G1/S Transit
ion",Mucopolysaccharidoses,"Transcriptional Regulation by TP53","Leishmania parasite growth and survival","Signaling by FLT3 ITD and TKD mutants","Toll Like Receptor 5 (TLR5) Cascade","Events associat
ed with phagocytolytic activity of PMN cells","Amine Oxidase reactions","Purine catabolism","Regulation of Complement cascade","SARS-CoV-1 Infection","Interferon alpha/beta signaling","PTEN Regulation
","G alpha (q) signalling events","G alpha (i) signalling events","Cell recruitment (pro-inflammatory response)","Ethanol oxidation","Negative regulation of the PI3K/AKT network","Virus Assembly and R
elease","Activation of NMDA receptors and postsynaptic events","Influenza Viral RNA Transcription and Replication",Aggrephagy,Synthesis,"and inactivation of Glucagon-like Peptide-1 (GLP-1)","G1 Phase"
,"Metabolism of steroid hormones","Class A/1 (Rhodopsin-like receptors)","Fatty acyl-CoA biosynthesis","Diseases associated with O-glycosylation of proteins","Caspase activation via Dependence Recepto
rs in the absence of ligand","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","Glycerophospholipid biosynthesis","Insulin receptor signalling cascade","SUMO E3 ligases SU
MOylate target proteins","LDL clearance","Transcriptional regulation by RUNX1","Interleukin-12 family signaling","Transcriptional regulation by RUNX3","SARS-CoV-2 Infection",Glycolysis,"Host Interacti
ons of HIV factors","Transcriptional regulation by RUNX2","Retinoid metabolism and transport","APC/C-mediated degradation of cell cycle proteins","Arachidonic acid metabolism","Transcriptional Regulat
ion by MECP2","Mitotic Anaphase","Interleukin-1 signaling",Xenobiotics,"Biosynthesis of DPAn-3 SPMs","Biosynthesis of D-series resolvins","Biosynthesis of maresins","Activation of the pre-replicative 
complex","MPS VII - Sly syndrome","Regulation of TP53 Activity","Anti-inflammatory response favouring Leishmania parasite infection","STAT5 activation downstream of FLT3 ITD mutants","MyD88 cascade in
itiated on plasma membrane","Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB","Endogenous sterols","SARS-CoV-1 Genome Replication and Transcription","Regulation of PTEN stabil
ity and activity","Gastrin-CREB signalling pathway via PKC and MAPK","Visual phototransduction","Purinergic signaling in leishmaniasis infection",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Asse
mbly of Viral Components at the Budding Site","Post NMDA receptor activation events","vRNA Synthesis","Cyclin D associated events in G1","Pregnenolone biosynthesis","Nucleotide-like (purinergic) recep
tors","Synthesis of very long-chain fatty acyl-CoAs","Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)","PCNA-Dependent Long Patch Base Excision Repair","Synthesis of PC","IRS-mediated 
signalling","SUMOylation of intracellular receptors","RUNX1 regulates estrogen receptor mediated transcription","Interleukin-12 signaling","RUNX3 Regulates Immune Response and Cell Migration","SARS-Co
V-2 Genome Replication and Transcription","The role of Nef in HIV-1 replication and disease pathogenesis","RUNX2 regulates bone development","Activation of APC/C and APC/C:Cdc20 mediated degradation o
f mitotic proteins","Synthesis of Leukotrienes (LT) and Eoxins (EX)","MECP2 regulates transcription factors","Nuclear Envelope (NE) Reassembly","MAP3K8 (TPL2)-dependent MAPK1/3 activation","CYP2E1 rea
ctions","Biosynthesis of DPAn-3-derived protectins and resolvins","Biosynthesis of maresin-like SPMs","Regulation of TP53 Activity through Phosphorylation","FCGR3A-mediated IL10 synthesis","MAP kinase
 activation","ADORA2B mediated anti-inflammatory cytokines production","Replication of the SARS-CoV-1 genome","EGFR Transactivation by Gastrin","The canonical retinoid cycle in rods (twilight vision)"
,"Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Transport of HA trimer","NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus","Activation of AMPK dow
nstream of NMDARs","Adenosine P1 receptors","Separation of Sister Chromatids","PI3K Cascade","TAK1 activates NFkB by phosphorylation and activation of IKKs complex","Gene and protein expression by JAK
-STAT signaling after Interleukin-12 stimulation","Replication of the SARS-CoV-2 genome","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","RUNX2 regulat
es osteoblast differentiation","APC/C:Cdc20 mediated degradation of mitotic proteins","Initiation of Nuclear Envelope (NE) Reformation","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Medi
ated CD4 Down-regulation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Activation of the AP-1 family of transcription factors","ERK/MAPK t
argets","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{AKR1B1,AR,CDK6,CFTR,CYP19A1,CYP1B1,HSD17B1}

> <broad_moa>
{"casein kinase inhibitor","cell proliferation inhibitor"}

> <synonyms>
{520-36-5,520365,"5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one","5,7Dihydroxy2(4hydroxyphenyl)4Hchromen4one",Chamomile,Versulin,"4',5,7-Trihydroxyflavone","4',5,7Trihydroxyflavone",Apigenol,Spig
enin,Apigenine,"C.I. Natural Yellow 1","Pelargidenon 1449","5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone","5,7Dihydroxy2(4hydroxyphenyl)4benzopyrone",5,7,4',T2175,EI-345,200846,Apigenin,APIGENIN}

> <pdid>
PD002200

> <targets>
{CK-II}

> <classes>
{antispasmodic,antineoplastic,"topoisomerase I inhibitor"}

> <pubchem_cids>
{5280443}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -6.4842    5.2598    0.0000 C   0  0
   -6.4790    6.7598    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 15 17  1  0
 17 18  3  0
  9 19  2  0
 19  5  1  0
 19 20  1  0
 20 21  2  0
 21  3  1  0
 21 22  1  0
 22 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28162

> <plate>
Kinase v5-1

> <well>
O13

> <supplier_cmpd_name>
BML-265

> <ctcr_id>
5076

> <supplier_cmpd_id>
EI-346

> <smiles>
COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OC

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ML26,"N-(3-Ethynylphenyl)-6,7-dimethoxy-4-quinazolinamine","N(3Ethynylphenyl)6,7dimethoxy4quinazolinamine","N-(3-ethynylphenyl)-6,7-dimethoxyquinazolin-4-amine","N(3ethynylphenyl)6,7dimethoxyquinazol
in4amine",CHEMBL304929,BiomolKI_000079,BiomolKI000079,BiomolKI-000079,"BiomolKI 000079",BiomolKI2_000083,BiomolKI2000083,BiomolKI2-000083,"BiomolKI2 000083",SCHEMBL667895,"4-Quinazolinamine,N-(3-ethyn
ylphenyl)-6,7-dimethoxy-","4Quinazolinamine,N(3ethynylphenyl)6,7dimethoxy",CHEBI:109555,BDBM5009525,EI-346,BML-265}

> <pdid>

> <targets>
{EGFRK}

> <classes>
{}

> <pubchem_cids>
{16045442}

$$$$
UTKinase_V5
  SciTegic11012413002D

 65 68  0  0  0  0            999 V2000
    1.9161   10.5654    0.0000 C   0  0
    3.3245   10.0492    0.0000 O   0  0
    3.5827    8.5707    0.0000 C   0  0
    2.4301    7.6108    0.0000 C   0  0
    2.6850    6.1326    0.0000 C   0  0
    4.0927    5.6144    0.0000 C   0  0
    5.2453    6.5743    0.0000 C   0  0
    4.9903    8.0525    0.0000 C   0  0
    6.1429    9.0124    0.0000 O   0  0
    1.5337    5.1698    0.0000 C   0  0
    1.7909    3.6911    0.0000 C   0  0
    3.1995    3.1753    0.0000 C   0  0
    0.6400    2.7300    0.0000 C   0  0
    0.8000    1.1200    0.0000 C   0  0
    2.0600    0.3500    0.0000 C   0  0
    1.8870   -1.1400    0.0000 O   0  0
    3.4300    0.8000    0.0000 C   0  0
    3.8662    2.2352    0.0000 C   0  0
    4.3600   -0.3900    0.0000 C   0  0
    5.8000   -0.4000    0.0000 C   0  0
    6.6151    0.8592    0.0000 C   0  0
    6.4400   -1.8000    0.0000 C   0  0
    7.9345   -1.9281    0.0000 O   0  0
    5.5100   -3.1600    0.0000 C   0  0
    4.0188   -3.2852    0.0000 O   0  0
    3.3799   -4.6424    0.0000 C   0  0
    6.5100   -4.2800    0.0000 C   0  0
    7.9504   -3.8613    0.0000 O   0  0
    6.2500   -5.8600    0.0000 C   0  0
    7.5042   -6.6827    0.0000 C   0  0
    4.8700   -6.7500    0.0000 C   0  0
    3.3400   -6.2300    0.0000 C   0  0
    2.3025   -7.3134    0.0000 C   0  0
    2.7800   -4.7900    0.0000 C   0  0
    1.1200   -4.8600    0.0000 C   0  0
    0.1200   -3.6900    0.0000 C   0  0
   -1.4100   -4.1500    0.0000 C   0  0
   -2.6300   -3.1700    0.0000 C   0  0
   -4.1200   -3.7800    0.0000 C   0  0
   -4.3154   -5.2672    0.0000 C   0  0
   -5.3700   -2.8300    0.0000 C   0  0
   -6.8600   -3.4400    0.0000 C   0  0
   -7.8600   -2.2400    0.0000 C   0  0
   -9.2500   -2.5000    0.0000 C   0  0
  -10.1800   -1.4400    0.0000 C   0  0
   -9.7100    0.0100    0.0000 C   0  0
  -10.7377    1.1027    0.0000 C   0  0
   -8.0800    0.4300    0.0000 C   0  0
   -8.4778    1.8763    0.0000 O   0  0
   -7.2300   -0.9300    0.0000 O   0  0
   -6.6100    0.8600    0.0000 C   0  0
   -5.5855   -0.2356    0.0000 O   0  0
   -6.1000    2.2500    0.0000 C   0  0
   -7.0129    3.4402    0.0000 O   0  0
   -4.5400    2.3900    0.0000 N   0  0
   -5.4800    3.8300    0.0000 C   0  0
   -4.8400    5.2900    0.0000 C   0  0
   -3.4600    5.5000    0.0000 C   0  0
   -2.6400    4.4900    0.0000 C   0  0
   -3.1200    3.1200    0.0000 C   0  0
   -1.9000    2.2900    0.0000 C   0  0
   -1.8545    0.7907    0.0000 O   0  0
   -0.7100    3.2100    0.0000 O   0  0
   -5.1674   -1.3437    0.0000 O   0  0
   -6.3526   -0.4242    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  8  9  1  0
  5 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  2  3
 20 21  1  0
 20 22  1  0
 22 23  1  0
 22 24  1  0
 24 25  1  0
 25 26  1  0
 24 27  1  0
 27 28  2  0
 27 29  1  0
 29 30  1  0
 29 31  1  0
 31 32  1  0
 32 33  1  0
 32 34  1  0
 34 35  2  3
 35 36  1  0
 36 37  2  3
 37 38  1  0
 38 39  2  3
 39 40  1  0
 39 41  1  0
 41 42  1  0
 42 43  1  0
 43 44  1  0
 44 45  1  0
 45 46  1  0
 46 47  1  0
 46 48  1  0
 48 49  1  0
 48 50  1  0
 50 43  1  0
 48 51  1  0
 51 52  2  0
 51 53  1  0
 53 54  2  0
 53 55  1  0
 55 56  1  0
 56 57  1  0
 57 58  1  0
 58 59  1  0
 59 60  1  0
 60 55  1  0
 60 61  1  0
 61 62  2  0
 61 63  1  0
 63 13  1  0
 41 64  1  0
 64 65  1  0
M  END
> <name>
UTKinase_V5

> <id>
28163

> <plate>
Kinase v5-1

> <well>
O15

> <supplier_cmpd_name>
Rapamycin

> <ctcr_id>
3116

> <supplier_cmpd_id>
A-275

> <smiles>
COC1CC(CCC1O)CC(C)C2CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C(C)C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC

> <pd_targets>
{FKBP1B,MAPT,FFP,FTL,TGR,RORC,FKBP1A,MTOR,NR1I2,FKBP5,EIF4E,ATP2A1,PDCD4,CYP2C9,CYP3A4,SLCO1B1,ABCB1,CYP2C19,FGF2}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Unclassified protein","Transcription factor","Other nuclear protein",Transporter,"Secreted protein",Isomerase,Transferase,"Nuclear receptor",Kinase,"Primary active t
ransporter","Cytochrome P450","Electrochemical transporter","Nuclear hormone receptor subfamily 1","Protein Kinase","P-type ATPase","Cytochrome P450 family 2","Cytochrome P450 family 3","SLC superfami
ly of solute carriers","ATP-binding cassette","Nuclear hormone receptor subfamily 1 group F","Atypical protein kinase group","Nuclear hormone receptor subfamily 1 group I","Calcium ATPase","Cytochrome
 P450 family 2C","Cytochrome P450 family 3A","SLC21/SLCO family of organic anion transporting polypeptides","ABCB subfamily","Nuclear hormone receptor subfamily 1 group F member 3","Atypical protein k
inase PIKK family","Nuclear hormone receptor subfamily 1 group I member 2","Cytochrome P450 2C9","Cytochrome P450 3A4","Cytochrome P450 2C19","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Nuclear hormone receptors","Peptidyl-prolyl cis/trans isomerases","Kinases (EC 2.7.x.x)","P-type ATPases","Cytochrome P450","SLC superfamily of solute carriers","ATP-b
inding cassette transporter family","1F. Retinoic acid-related orphans",Atypical,"1I. Vitamin D receptor-like receptors","P2A P-type ATPases: Ca<sup>2+</sup>-ATPases","CYP2 family: drug metabolising s
ubset","CYP3 family","SLCO family of organic anion transporting polypeptides","ABCB subfamily","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Muscle contraction","Neuronal System","Vesicle-mediated transport","Gene expression (Transcription)",Disease,"Metabolism of proteins",Hemostasis,"Immune System",Metabolism,"Cardiac conduction","Tran
smission across Chemical Synapses","Membrane Trafficking","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Post-translational prote
in modification",Translation,"Platelet homeostasis","Cytokine Signaling in Immune system","Biological oxidations","Metabolism of lipids","Abacavir transport and metabolism","Ion homeostasis","Neurotra
nsmitter receptors and postsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Generic Transcription Pathway","Signaling by TGF-beta Receptor Complex in Cancer",SUMOylation,"Eukaryoti
c Translation Initiation","Platelet calcium homeostasis","Signaling by Interleukins","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","Metabolism 
of steroids","Abacavir transmembrane transport","Signaling by FGFR in disease","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis","Transcriptional regulation 
by RUNX3","Loss of Function of TGFBR1 in Cancer","Transcriptional Regulation by TP53","SUMO E3 ligases SUMOylate target proteins","Transcriptional Regulation by MECP2","Cap-dependent Translation Initi
ation","Reduction of cytosolic Ca++ levels","Interleukin-12 family signaling","Cytochrome P450 - arranged by substrate type","Biosynthesis of DHA-derived SPMs","Bile acid and bile salt metabolism","Si
gnaling by FGFR3 in disease","Post NMDA receptor activation events","RUNX3 Regulates Immune Response and Cell Migration","TGFBR1 LBD Mutants in Cancer","Regulation of TP53 Activity","SUMOylation of in
tracellular receptors","MECP2 regulates neuronal receptors and channels","Activation of the mRNA upon binding of the cap-binding complex and eIFs","and subsequent binding to 43S","Interleukin-12 signa
ling",Xenobiotics,"Biosynthesis of maresins","Recycling of bile acids and salts","Signaling by FGFR3 point mutants in cancer","Activation of AMPK downstream of NMDARs","Regulation of TP53 Expression a
nd Degradation","Translation initiation complex formation","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","CYP2E1 reactions","Biosynthesis of maresin-like SPMs","
FGFR3 mutant receptor activation","Regulation of TP53 Degradation","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
{FKBP1A,MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{(RS)-rapamycin,(RS)rapamycin,"Rapamycin (Sirolimus)",28-epi-Rapamycin,28epiRapamycin,253431-35-5,253431355,SpecPlus_000840,SpecPlus000840,SpecPlus-000840,"SpecPlus 000840",DivK1c_006936,DivK1c006936,
DivK1c-006936,"DivK1c 006936","Rapamycin-d3 (Sirolimus-d3)","Rapamycind3 (Sirolimusd3)",CHEMBL3560003,KBio1_001880,KBio1001880,KBio1-001880,"KBio1 001880",HMS3265I15,HMS3265I16,HMS3265J15,HMS3265J16,3
92711-19-2,392711192,MCULE-7980881185,MCULE7980881185,Q27163,"EMD 553210",S1039,A-275,553210,Rapamycin(Sirolimus),Rapamycin}

> <pdid>
PD003274

> <targets>
{mTOR}

> <classes>
{}

> <pubchem_cids>
{5040}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  1  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 C   0  0
    0.0079    7.5003    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  3  2  1  1
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
  9 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 21 25  1  0
 25 18  1  0
 25 26  2  0
 26  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28164

> <plate>
Kinase v5-1

> <well>
O17

> <supplier_cmpd_name>
Roscovitine

> <ctcr_id>
1691

> <supplier_cmpd_id>
CC-205

> <smiles>
CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1

> <pd_targets>
{LMNA,CCNE1,CDK2,CCNH,CDK7,MNAT1,CCNB1,CDK1,CCNA1,CCNA2,MAPK1,DYRK1B,GMNN,CLK1,DYRK1A,CDK5,CDK5R1,GSK3-BETA,GSK3A,CCNT1,CDK9,RPS6KA2,CSNK1G2,CCND1,CDK4,CCNE2,MAPK3,CSNK1D,CSNK1A1,CDK6,CDK16,CLK2,CSNK1
E,GSK3B,SMN1,CLK4,CCNB2,CCNB3,CSNK1G3,DYRK2,CSNK1G1,SYN1,THRB,PMP22,PAK4,ALK,TTK,CACNA1C,CACNA1B,SRPK1,HIPK4,CYP2D6,CYP1A2,NFKB1,HIF1A,CHRM1,CYP3A4,CYP2C9,TSHR}

> <pathway_gtopdb>
{"Other nuclear protein",Enzyme,"Unclassified protein","Epigenetic regulator","Other cytosolic protein","Transcription factor","Ion channel",Kinase,Reader,"Nuclear receptor","Voltage-gated ion channel
","Protein Kinase","Methyl-lysine/arginine binding protein","Nuclear hormone receptor subfamily 1","Voltage-gated calcium channel","CMGC protein kinase group","AGC protein kinase group","CK1 protein k
inase group","Tudor domain","Nuclear hormone receptor subfamily 1 group A","STE protein kinase group","TKL protein kinase group","Other protein kinase group","CMGC protein kinase CDK family","CMGC pro
tein kinase MAPK family","CMGC protein kinase DYRK family","CMGC protein kinase CLK family","CMGC protein kinase GSK family","AGC protein kinase RSK family","CK1 protein kinase CK1 family","Nuclear ho
rmone receptor subfamily 1 group A member 2","STE protein kinase STE20 family","TKL protein kinase STKR family","Other protein kinase TTK family","CMGC protein kinase CDC2 subfamily","CMGC protein kin
ase CDK7 subfamily","CMGC protein kinase ERK1","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK9 subfamily","AGC protein kinase RSK subfamily","CMGC 
protein kinase TAIRE subfamily","CK1 protein kinase CK1-g","CMGC protein kinase Dyrk2 subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase SRP
K family","CMGC protein kinase HIPK subfamily","Membrane receptor","Cytochrome P450","Family A G protein-coupled receptor","Cytochrome P450 family 2","Cytochrome P450 family 1","Small molecule recepto
r (family A GPCR)","Cytochrome P450 family 3","Peptide receptor (family A GPCR)","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Monoamine receptor","Cytochrome P450 family 3A","Cytochrome P4
50 family 2C","Glycohormone receptor","Cytochrome P450 2D6","Cytochrome P450 1A1","Acetylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 2C9"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Catalytic receptors","Voltage-gated ion channels","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing
 PKA",PKG,"PKC families","CK1: Casein kinase 1","1A. Thyroid hormone receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","Voltage-gated calcium channels"
,"Cyclin-dependent kinase (CDK) family","Mitogen-activated protein kinases (MAP kinases)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CLK family","RSK family","Case
in kinase 1 (CK1) family","STE20 family","TK: Tyrosine kinase","Other protein kinases","CDK1 subfamily","ERK subfamily","Dyrk1 subfamily","CDK5 subfamily","RSK subfamily","CDK9 subfamily","TAIRE subfa
mily","CDK4 subfamily","Dyrk2 subfamily","CDK7 subfamily","PAKB subfamily","Receptor tyrosine kinases (RTKs)","TTK family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","SRPK family
","HIPK subfamily","Cytochrome P450","G protein-coupled receptors","CYP2 family: drug metabolising subset","CYP1 family","Acetylcholine receptors (muscarinic)","CYP3 family","Glycoprotein hormone rece
ptors"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)","Immune System",Metabolism,Disease,"Metabolism of RNA","Neuronal System","Metabolism of proteins","Developmental Biology",Mitotic,"RNA Polymerase II Tra
nscription","Innate Immune System","Metabolism of lipids","Infectious disease","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of non-coding RNA","Transm
ission across Chemical Synapses","Post-translational protein modification","Nervous system development","M Phase","Generic Transcription Pathway","Toll-like Receptor Cascades","Mitotic G1 phase and G1
/S transition","Sphingolipid metabolism","HIV Infection","Mitotic G2-G2/M phases","Signaling by WNT in cancer","snRNP Assembly","Regulation of mitotic cell cycle","Neurotransmitter release cycle",SUMO
ylation,"EGR2 and SOX10-mediated initiation of Schwann cell myelination","Axon guidance","Presynaptic depolarization and calcium channel opening","Mitotic Metaphase and Anaphase","Transcriptional Regu
lation by TP53","Toll Like Receptor 5 (TLR5) Cascade","G1/S Transition","G0 and Early G1","Sphingolipid de novo biosynthesis","HIV Life Cycle","G2/M Transition","Signaling by AMER1 mutants","APC/C-med
iated degradation of cell cycle proteins","G1 Phase","Dopamine Neurotransmitter Release Cycle","SUMO E3 ligases SUMOylate target proteins","Signaling by ROBO receptors","NCAM signaling for neurite out
-growth","Mitotic Anaphase","Regulation of TP53 Activity","MyD88 cascade initiated on plasma membrane","Activation of the pre-replicative complex","Late Phase of HIV Life Cycle","Centrosome maturation
","Truncations of AMER1 destabilize the destruction complex","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Cyclin D associated events in G1","SUMOylation of intracell
ular receptors","Activation of RAC1","NCAM1 interactions","Nuclear Envelope (NE) Reassembly","Regulation of TP53 Expression and Degradation","MAP kinase activation","Regulation of TP53 Activity throug
h Phosphorylation","Transcription of the HIV genome","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic proteins","Ini
tiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","HIV Transcription Elongation","Loss of Nlp from mitotic centrosom
es","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","CREB phosphorylation","Tat-mediated elongation of the HIV-1 transcript
","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated","Formation of HIV-1 elongation complex containing HIV-1 Tat","Cellular responses to external stimuli","Signal Transducti
on","Biological oxidations","Cytokine Signaling in Immune system","Cellular responses to stress","Signaling by GPCR","Phase I - Functionalization of compounds","Signaling by Interleukins","Cellular re
sponse to hypoxia","GPCR ligand binding","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","Cytochrome P450 - arranged by substrate type","Interleukin-1 family signali
ng","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Leishmania parasite growth and survival",Xenob
iotics,"Interleukin-1 signaling","Amine ligand-binding receptors","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","CYP2E1 reactions","Aromatic amines ca
n be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammator
y cytokines production"}

> <broad_targets>
{CDK2,CDK9}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{roscovitine,Seliciclib,186692-46-6,186692466,R-Roscovitine,RRoscovitine,(R)-roscovitine,(R)roscovitine,CYC202,CYC-202,"CYC 202","Roscovitine (Seliciclib,CYC202)",2-(R)-(1-Ethyl-2-hydroxyethylamino)-6
-benzylamino-9-isopropylpurine,2(R)(1Ethyl2hydroxyethylamino)6benzylamino9isopropylpurine,UNII-0ES1C2KQ94,UNII0ES1C2KQ94,(R)-2-((6-(Benzylamino)-9-isopropyl,(R)2((6(Benzylamino)9isopropyl,T2095,S1153,
CC-205,"EMD 557360",Roscovitine,Roscovitine(CYC202),557360,ROSCOVITINE}

> <pdid>
PD011113

> <targets>
{CDK,cdk5,cdc2,cdk2}

> <classes>
{}

> <pubchem_cids>
{160355}

$$$$
UTKinase_V5
  SciTegic11012413002D

 19 21  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 16 17  2  0
 17 11  1  0
 17 18  1  0
 18  8  1  0
 18 19  2  0
M  END
> <name>
UTKinase_V5

> <id>
28165

> <plate>
Kinase v5-1

> <well>
O19

> <supplier_cmpd_name>
Daidzein

> <ctcr_id>
2933

> <supplier_cmpd_id>
ST-110

> <smiles>
Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O

> <pd_targets>
{MAOA,MAOB,ESR1,ESR2,KDM4E,SMN1,FABZ,ALDH1A1,HPGD,TP53,CA4,MAPT,NPC1,CYP3A4,NA,HSD17B10,PMP22,THPO,CYP1A2,CA12,CA7,CYP2C19,BLM,CYP2D6,CYP2C9,PYK,ALDH2,LMNA,NFKB1,PKM,RAB9A,AKR1B10,CYP19A1,UGT1A1,CACNA
1C,TRPC5,ESRRG,ESRRB,ESRRA}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator","Other cytosolic protein",Transporter,"Unclassified protein","Other nuclear protein","Ion channel",Oxidoreductase,"Nuclear receptor",Eraser,Reader
,Lyase,"Cytochrome P450",Hydrolase,Transferase,"Voltage-gated ion channel","Nuclear hormone receptor subfamily 3","Lysine demethylase","Methyl-lysine/arginine binding protein","Cytochrome P450 family 
3","Cytochrome P450 family 1","Cytochrome P450 family 2","Cytochrome P450 family 19","Voltage-gated calcium channel","Transient receptor potential channel","Nuclear hormone receptor subfamily 3 group 
A","Jumonji domain-containing","Tudor domain","Cytochrome P450 family 3A","Cytochrome P450 family 1A","Cytochrome P450 family 2C","Cytochrome P450 family 2D","Cytochrome P450 family 19A","Nuclear horm
one receptor subfamily 3 group B","Nuclear hormone receptor subfamily 3 group A member 1","Nuclear hormone receptor subfamily 3 group A member 2","Cytochrome P450 3A4","Cytochrome P450 1A1","Cytochrom
e P450 2C19","Cytochrome P450 2D6","Cytochrome P450 2C9","Cytochrome P450 19A1","Nuclear hormone receptor subfamily 3 group B member 3","Nuclear hormone receptor subfamily 3 group B member 2","Nuclear
 hormone receptor subfamily 3 group B member 1"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Ion channels","Nuclear hormone receptors","Chromatin modifying enzymes","Eicosanoid turnover","Carbonic anhydrases","SLC superfamily of solute carriers","Cytochrome P4
50","1.-.-.- Oxidoreductases","2.7.1.40 Pyruvate kinases","UDP glucuronosyltransferases (UGT)","Voltage-gated ion channels","Steroid hormone receptors","1.14.11.- Histone demethylases","Prostaglandin 
synthases","SLC65 NPC-type cholesterol transporters","CYP3 family","CYP1 family","CYP2 family: drug metabolising subset",CYP11,CYP17,CYP19,"CYP20 and CYP21 families","Voltage-gated calcium channels","
Transient Receptor Potential channels","3B. Estrogen-related receptors","3A. Estrogen receptors"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Metabolism of RNA",Metabolism,"Cell Cycle","Transport of small molecules","Neuronal System","Developmental Biology",Hemostasis,"DNA Repair","I
mmune System",Disease,"RNA Polymerase II Transcription","Intracellular signaling by second messengers","Metabolism of non-coding RNA","Biological oxidations","Metabolism of lipids","Cell Cycle Checkpo
ints","O2/CO2 exchange in erythrocytes","Transmission across Chemical Synapses","Plasma lipoprotein assembly",remodeling,"and clearance","Metabolism of amino acids and derivatives","Nervous system dev
elopment","Platelet activation","signaling and aggregation","Reversible hydration of carbon dioxide","DNA Double-Strand Break Repair",Mitotic,"Cytokine Signaling in Immune system","Metabolism of carbo
hydrates","Infectious disease","Signaling by Rho GTPases","Metabolism of vitamins and cofactors","Diseases of metabolism","Generic Transcription Pathway","PIP3 activates AKT signaling","snRNP Assembly
","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","G1/S DNA Damage Checkpoints","Erythrocytes take up carbon dioxide and release oxygen","Neurotr
ansmitter receptors and postsynaptic signal transmission","Plasma lipoprotein clearance","Branched-chain amino acid catabolism","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Platel
et Aggregation (Plug Formation)","Homology Directed Repair","Neurotransmitter clearance","M Phase","Signaling by Interleukins","Glucose metabolism","Influenza Infection","Rho GTPase cycle","Metabolism
 of fat-soluble vitamins","Metabolic disorders of biological oxidation enzymes","Axon guidance","Transcriptional regulation by RUNX1","Negative regulation of the PI3K/AKT network","Ethanol oxidation",
"Biosynthesis of DHA-derived SPMs","p53-Dependent G1/S DNA damage checkpoint","Activation of NMDA receptors and postsynaptic events","LDL clearance","Cytochrome P450 - arranged by substrate type","HDR
 through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Serotonin clearance from the synaptic cleft","Mitotic Metaphase and Anaphase","Interleukin-1 family signaling",Glycolysis,"Vi
rus Assembly and Release","RHOBTB GTPase Cycle","Retinoid metabolism and transport","Defective UGT1A1 causes hyperbilirubinemia","NCAM signaling for neurite out-growth","Netrin-1 signaling","Nuclear R
eceptor transcription pathway","Transcriptional regulation by RUNX2","RUNX1 regulates estrogen receptor mediated transcription",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Biosynthesis of D-seri
es resolvins","p53-Dependent G1 DNA Damage Response","Post NMDA receptor activation events","Biosynthesis of maresins",Xenobiotics,"HDR through Homologous Recombination (HRR)","Metabolism of serotonin
","Mitotic Anaphase","Interleukin-1 signaling","Assembly of Viral Components at the Budding Site","RHOBTB3 ATPase cycle","Endogenous sterols","NCAM1 interactions","Role of second messengers in netrin-
1 signaling","Regulation of RUNX2 expression and activity","Stabilization of p53","Activation of AMPK downstream of NMDARs","Biosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated o
r N-dealkylated by CYP1A2","CYP2E1 reactions","Homologous DNA Pairing and Strand Exchange","Nuclear Envelope (NE) Reassembly","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Transport of HA trimer","NA 
tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus","Autodegradation of the E3 ubiquitin ligase COP1","Presynaptic phase of homologous DNA pairing and strand exchange","Ini
tiation of Nuclear Envelope (NE) Reformation"}

> <broad_targets>
{ESRRA,ESRRB,ESRRG,TRPC5}

> <broad_moa>
{"estrogen receptor agonist"}

> <synonyms>
{daidzein,486-66-8,486668,"4',7-Dihydroxyisoflavone","4',7Dihydroxyisoflavone",Daidzeol,"7,4'-Dihydroxyisoflavone","7,4'Dihydroxyisoflavone",7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one,7hydroxy3(4h
ydroxyphenyl)4Hchromen4one,7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one,7hydroxy3(4hydroxyphenyl)chromen4one,7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one,7Hydroxy3(4hydroxyphenyl)4H1benzopyran4on
e,4H-1-Benzopyran-4-one,4H1Benzopyran4one,T1238,ST-110,200789,Daidzein,DAIDZEIN}

> <pdid>
PD002203

> <targets>
{"Negative control for Genistein."}

> <classes>
{phytoestrogen}

> <pubchem_cids>
{5281708}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 23  0  0  0  0            999 V2000
    4.6379    5.2745    0.0000 Br  0  0
    4.3480    3.8028    0.0000 C   0  0
    5.4777    2.8159    0.0000 C   0  0
    5.1878    1.3442    0.0000 C   0  0
    3.7691    0.8603    0.0000 C   0  0
    3.1796   -0.5190    0.0000 N   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.5242    2.0130    0.0000 O   0  0
   -1.6852   -0.3847    0.0000 N   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.5000   -2.8577    0.0000 C   0  0
   -0.7500   -4.1567    0.0000 C   0  0
    0.7500   -4.1567    0.0000 C   0  0
    1.5000   -2.8577    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    2.6395    1.8472    0.0000 C   0  0
    2.9286    3.3180    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  7  1  0
 18 13  1  0
  8 19  1  0
 19  5  1  0
 19 20  2  0
 20  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28166

> <plate>
Kinase v5-1

> <well>
O21

> <supplier_cmpd_name>
Kenpaullone

> <ctcr_id>
489

> <supplier_cmpd_id>
EI-310

> <smiles>
Brc1ccc2[nH]c3c(CC(=O)Nc4ccccc34)c2c1

> <pd_targets>
{MARK3,CCNB1,CDK1,ALDH1A1,KMT2A,MEN1,TP53,HTT,CYP2D6,GMNN,CDC42BPA,PLK4,LIMK1,CDC7,FLT4,CDK2,GSK3B,SRC,AURKB,CCNA1,CCNA2,CHEK1,CDK5,CDK5R1,CSNK2A1,CHEK2,MAPT,CHRM1,CYP1A2,ABL1,MARK2,FLT1,LCK,MAPK3,NFK
B1,RAB9A,SMN1,NPC1,THPO,DYRK1A,LMNA,CCNB2,CCNB3,PFMRK,PIM1,PDPK1,STK3,KDR,TSHR,HIF1A,CYP3A4,AURKA,LYN,MAPK1,THRB,NFO,RORC,BLM,CSF1R,NIN,GSK3A,ROCK2,KDM4E,PYK,FYN,HSD17B10,PMP22,PKM,CYP2C9,FLT3,ROCK1,M
TOR,CCNT1,CDK9}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Transcription factor","Unclassified protein","Other cytosolic protein","Membrane receptor",Transporter,"Other nuclear protein",Kinase,Protease,Oxidoreductase,Reader,"Cy
tochrome P450","Family A G protein-coupled receptor",Hydrolase,"Nuclear receptor",Eraser,Transferase,"Protein Kinase","Cysteine protease",Bromodomain,"Cytochrome P450 family 2","Small molecule recepto
r (family A GPCR)","Cytochrome P450 family 1","Methyl-lysine/arginine binding protein","Peptide receptor (family A GPCR)","Cytochrome P450 family 3","Nuclear hormone receptor subfamily 1","Lysine deme
thylase","CAMK protein kinase group","CMGC protein kinase group","Cysteine protease CA clan","Cytochrome P450 family 2D","AGC protein kinase group","Other protein kinase group","TKL protein kinase gro
up","TK protein kinase group","Monoamine receptor","Cytochrome P450 family 1A","Tudor domain","STE protein kinase group","Glycohormone receptor","Cytochrome P450 family 3A","Nuclear hormone receptor s
ubfamily 1 group A","Nuclear hormone receptor subfamily 1 group F","Jumonji domain-containing","Cytochrome P450 family 2C","Atypical protein kinase group","CAMK protein kinase CAMK1 family","CMGC prot
ein kinase CDK family","Cysteine protease C1A family","Cytochrome P450 2D6","AGC protein kinase DMPK family","Other protein kinase PLK family","TKL protein kinase LISK family","Other protein kinase CD
C7 family","Tyrosine protein kinase VEGFR family","CMGC protein kinase GSK family","Tyrosine protein kinase Src family","Other protein kinase AUR family","Other protein kinase CK2 family","CAMK protei
n kinase RAD53 family","Acetylcholine receptor","Cytochrome P450 1A1","Tyrosine protein kinase Abl family","CMGC protein kinase MAPK family","CMGC protein kinase DYRK family","CAMK protein kinase PIM 
family","AGC protein kinase PDK1 subfamily","STE protein kinase STE20 family","Cytochrome P450 3A4","Nuclear hormone receptor subfamily 1 group A member 2","Nuclear hormone receptor subfamily 1 group 
F member 3","Tyrosine protein kinase PDGFR family","Cytochrome P450 2C9","Atypical protein kinase PIKK family","CAMK protein kinase MARK subfamily","CMGC protein kinase CDC2 subfamily","AGC protein ki
nase GEK subfamily","TKL protein kinase LIMK subfamily","CAMK protein kinase CHK1 subfamily","CMGC protein kinase ERK1","CMGC protein kinase CDK5 subfamily","CMGC protein kinase Dyrk1 subfamily","STE 
protein kinase MST subfamily","AGC protein kinase ROCK subfamily","Tyrosine protein kinase SrcA","Atypical protein kinase FRAP subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Kinases (EC 2.7.x.x)","Cytochrome P450","Catalytic receptors","G protein-coupled receptors","SLC superfamily of solute carriers","Nuclear hormone receptors","Chromatin
 modifying enzymes","2.7.1.40 Pyruvate kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CYP2 family: drug metabolising subset","AGC: Containing PKA",PKG,"PKC families","Receptor kinases"
,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","Acetylcholine receptors (muscarinic)","CYP1 family","SLC65 NPC-type cholesterol transporters","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile
 20 kinases","Glycoprotein hormone receptors","CYP3 family","1A. Thyroid hormone receptors","1F. Retinoic acid-related orphans","1.14.11.- Histone demethylases",Atypical,"CAMK-like (CAMKL) family","DM
PK family","Other protein kinases","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","Glycogen synthase kinase (GSK) family","Mitogen-activated protein kinases (
MAP kinases)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","PIM family","PDK1 family","STE20 family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","
MARK subfamily","GEK subfamily","Polo-like kinase (PLK) family","LIM domain kinase (LISK) family","CDC7 family","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","GSK subfamily","Non-receptor tyrosi
ne kinases (nRTKs)","Aurora kinase (Aur) family","CHK1 subfamily","Casein kinase 2 (CK2) family","ERK subfamily","CDK5 subfamily","Dyrk1 subfamily","MST subfamily","Rho kinase","FRAP subfamily","LIMK 
subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Src family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{Disease,Metabolism,"Cell Cycle","Gene expression (Transcription)","Developmental Biology","Signal Transduction","DNA Repair","Neuronal System","Immune System","Metabolism of RNA","Transport of small 
molecules",Hemostasis,"Cellular responses to external stimuli","Metabolism of proteins","Diseases of signal transduction by growth factor receptors and second messengers","Biological oxidations","Cell
 Cycle Checkpoints","RNA Polymerase II Transcription",Mitotic,"Nervous system development","Signaling by Receptor Tyrosine Kinases","Infectious disease","DNA Double-Strand Break Repair","Transmission 
across Chemical Synapses","Signaling by GPCR","Innate Immune System","Cytokine Signaling in Immune system","Signaling by Rho GTPases","Metabolism of non-coding RNA","Plasma lipoprotein assembly",remod
eling,"and clearance","Platelet activation","signaling and aggregation","Signaling by Hippo","Cellular responses to stress","Metabolism of lipids","Post-translational protein modification","Metabolism
 of amino acids and derivatives","Metabolism of carbohydrates","Oncogenic MAPK signaling","Phase I - Functionalization of compounds","G1/S DNA Damage Checkpoints","Generic Transcription Pathway","Mito
tic G1 phase and G1/S transition","Mitotic G2-G2/M phases","Axon guidance","Signaling by VEGF","SARS-CoV Infections","Signaling by NTRKs","M Phase","Homology Directed Repair","Neurotransmitter recepto
rs and postsynaptic signal transmission","GPCR ligand binding","Leishmania infection","HIV Infection","Toll-like Receptor Cascades","Signaling by Interleukins","Rho GTPase cycle","snRNP Assembly","Pla
sma lipoprotein clearance","Platelet Aggregation (Plug Formation)","FLT3 signaling in disease","Cellular response to hypoxia","Biosynthesis of specialized proresolving mediators (SPMs)",SUMOylation,"B
ranched-chain amino acid catabolism","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Glucose metabolism","Signaling by Insulin receptor","Regulation of mitotic cell cycle","Signaling
 by RAS mutants","Ethanol oxidation","p53-Dependent G1/S DNA damage checkpoint","Transcriptional Regulation by MECP2","Cytochrome P450 - arranged by substrate type","G1/S Transition","G2/M Transition"
,"Semaphorin interactions","VEGF ligand-receptor interactions","Transcriptional Regulation by TP53","SARS-CoV-1 Infection","Signaling by NTRK1 (TRKA)","Mitotic Metaphase and Anaphase","HDR through Hom
ologous Recombination (HRR) or Single Strand Annealing (SSA)","Activation of NMDA receptors and postsynaptic events","Class A/1 (Rhodopsin-like receptors)","Parasite infection","Host Interactions of H
IV factors","Toll Like Receptor 5 (TLR5) Cascade","Interleukin-1 family signaling","RHOBTB GTPase Cycle","LDL clearance","G0 and Early G1","Signaling by FLT3 ITD and TKD mutants","VEGFA-VEGFR2 Pathway
","Leishmania parasite growth and survival","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Biosynthesis of DHA-derived SPMs","SUMO E3 ligases SUMOylate target proteins","T
ranscriptional regulation by RUNX3","Transcriptional Regulation by VENTX",Glycolysis,"Insulin receptor signalling cascade","APC/C-mediated degradation of cell cycle proteins","Signaling downstream of 
RAS mutants","p53-Dependent G1 DNA Damage Response","Regulation of MECP2 expression and activity",Xenobiotics,"Activation of the pre-replicative complex","Centrosome maturation","Sema4D in semaphorin 
signaling","VEGF binds to VEGFR leading to receptor dimerization","Regulation of TP53 Activity","SARS-CoV-1 Genome Replication and Transcription","Signalling to ERKs","Mitotic Anaphase","HDR through H
omologous Recombination (HRR)","Post NMDA receptor activation events","Amine ligand-binding receptors","Leishmania phagocytosis","The role of Nef in HIV-1 replication and disease pathogenesis","MyD88 
cascade initiated on plasma membrane","Interleukin-1 signaling","RHOBTB3 ATPase cycle","STAT5 activation downstream of FLT3 ITD mutants","VEGFR2 mediated cell proliferation","Anti-inflammatory respons
e favouring Leishmania parasite infection","Biosynthesis of maresins","SUMOylation of intracellular receptors","RUNX3 Regulates Immune Response and Cell Migration","IRS-mediated signalling","Activatio
n of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Stabilization of p53","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","
Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-1 genome","Signalling to RAS","Separation of Sister Chromatids","Ho
mologous DNA Pairing and Strand Exchange","Regulation of TP53 Activity through Phosphorylation","Activation of AMPK downstream of NMDARs","Muscarinic acetylcholine receptors","Aromatic amines can be N
-hydroxylated or N-dealkylated by CYP1A2","FCGR3A-mediated phagocytosis","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","MAP kinase activation","MAP3K
8 (TPL2)-dependent MAPK1/3 activation","Nuclear Envelope (NE) Reassembly","ADORA2B mediated anti-inflammatory cytokines production","Biosynthesis of maresin-like SPMs","FCGR3A-mediated IL10 synthesis"
,"Nef and signal transduction","PI3K Cascade","APC/C:Cdc20 mediated degradation of mitotic proteins","Autodegradation of the E3 ubiquitin ligase COP1","Loss of Nlp from mitotic centrosomes","Regulatio
n of TP53 Degradation","p38MAPK events","Presynaptic phase of homologous DNA pairing and strand exchange","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","Ini
tiation of Nuclear Envelope (NE) Reformation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated
 degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CCNB1,CDK1,CDK5,GSK3B}

> <broad_moa>
{"CDK inhibitor","glycogen synthase kinase inhibitor"}

> <synonyms>
{kenpaullone,142273-20-9,142273209,9-Bromopaullone,9Bromopaullone,"NSC 664704","9-Bromo-7,12-dihydroindolo(3,2-d)(1)benzazepin-6(5H)-one","9Bromo7,12dihydroindolo(3,2d)(1)benzazepin6(5H)one",NSC-66470
4,NSC664704,9-Bromopaullone;NSC-664704,9Bromopaullone;NSC664704,"9-bromo-7,12-dihydrobenzo(2,3)azepino(4,5-b)indol-6(5H)-one","9bromo7,12dihydrobenzo(2,3)azepino(4,5b)indol6(5H)one",Indolo(3,2-d)(1)be
nz,2d)(1)benz,T2247,"EMD 422000",EI-310,KenPaullone,422000,Kenpaullone}

> <pdid>
PD002702

> <targets>
{CDK,GSK-3beta}

> <classes>
{}

> <pubchem_cids>
{3820}

$$$$
UTKinase_V5
  SciTegic11012413002D

 96110  0  0  0  0            999 V2000
    2.5795   -7.5040    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    5.2507    0.0000 C   0  0
   -2.5969    6.0029    0.0000 C   0  0
   -2.5945    7.5029    0.0000 C   0  0
   -1.2943    8.2509    0.0000 C   0  0
    0.0035    7.4988    0.0000 C   0  0
    0.0012    5.9988    0.0000 C   0  0
   -1.2889    9.7517    0.0000 C   0  0
    0.0131   10.4982    0.0000 N   0  0
    0.0208   11.9982    0.0000 C   0  0
    1.3236   12.7416    0.0000 C   0  0
    2.6188   11.9851    0.0000 C   0  0
    2.6113   10.4851    0.0000 C   0  0
    1.3085    9.7417    0.0000 C   0  0
    3.9223   12.7289    0.0000 N   0  0
    4.0699   14.2081    0.0000 C   0  0
    3.0735   15.3293    0.0000 C   0  0
    3.5462   16.7528    0.0000 C   0  0
    5.0154   17.0552    0.0000 C   0  0
    6.0119   15.9340    0.0000 C   0  0
    5.5391   14.5104    0.0000 C   0  0
    6.2805   13.2074    0.0000 N   0  0
    5.2696   12.0992    0.0000 C   0  0
    5.5633   10.6282    0.0000 O   0  0
   -3.8978    3.7504    0.0000 C   0  0
   -5.1981    3.0025    0.0000 C   0  0
   -6.4960    3.7545    0.0000 C   0  0
   -6.4936    5.2545    0.0000 C   0  0
   -5.1934    6.0025    0.0000 C   0  0
   -3.8955    5.2504    0.0000 C   0  0
   22.7963   -6.6881    0.0000 C   0  0
   22.8015   -5.1881    0.0000 N   0  0
   24.1031   -4.4426    0.0000 C   0  0
   24.1083   -2.9426    0.0000 C   0  0
   22.8119   -2.1880    0.0000 N   0  0
   21.5103   -2.9336    0.0000 C   0  0
   21.5051   -4.4336    0.0000 C   0  0
   22.8140   -0.6872    0.0000 C   0  0
   24.1144    0.0605    0.0000 O   0  0
   21.5158    0.0659    0.0000 C   0  0
   21.5158    1.5659    0.0000 C   0  0
   20.2168    2.3159    0.0000 C   0  0
   18.9177    1.5659    0.0000 C   0  0
   18.9177    0.0659    0.0000 C   0  0
   20.2168   -0.6841    0.0000 C   0  0
   17.6187    2.3159    0.0000 N   0  0
   17.6187    3.8159    0.0000 C   0  0
   18.9177    4.5659    0.0000 C   0  0
   20.2168    3.8159    0.0000 N   0  0
   18.9177    6.0666    0.0000 C   0  0
   17.6199    6.8188    0.0000 C   0  0
   17.6222    8.3188    0.0000 C   0  0
   18.9225    9.0667    0.0000 C   0  0
   20.2203    8.3147    0.0000 C   0  0
   20.2179    6.8147    0.0000 C   0  0
   16.3190    4.5662    0.0000 C   0  0
   15.0187    3.8183    0.0000 C   0  0
   13.7208    4.5704    0.0000 C   0  0
   13.7232    6.0704    0.0000 C   0  0
   15.0234    6.8183    0.0000 C   0  0
   16.3213    6.0663    0.0000 C   0  0
   12.4262    6.8255    0.0000 C   0  0
   12.4307    8.3264    0.0000 N   0  0
   11.1355    9.0830    0.0000 C   0  0
   11.1430   10.5830    0.0000 C   0  0
   12.4458   11.3264    0.0000 C   0  0
   13.7411   10.5699    0.0000 C   0  0
   13.7335    9.0699    0.0000 C   0  0
   12.4534   12.8271    0.0000 N   0  0
   11.2462   13.6946    0.0000 C   0  0
    9.7770   13.3922    0.0000 C   0  0
    8.7805   14.5134    0.0000 C   0  0
    9.2533   15.9370    0.0000 C   0  0
   10.7225   16.2393    0.0000 C   0  0
   11.7190   15.1181    0.0000 C   0  0
   13.2181   15.1087    0.0000 N   0  0
   13.6724   13.6791    0.0000 C   0  0
   15.0931   13.1980    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  3
 15 10  1  0
 13 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  3
 19 12  1  0
 18 20  1  0
 20 21  2  3
 21 22  1  0
 22 23  2  3
 23 24  1  0
 24 25  2  3
 25 20  1  0
 23 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 27  1  0
 30 33  1  0
 33 34  1  0
 34 35  2  3
 35 36  1  0
 36 37  2  3
 37 38  1  0
 38 39  2  3
 39 34  1  0
 39 40  1  0
 40 41  1  0
 41 33  1  0
 41 42  2  0
 17 43  1  0
 43 44  2  3
 44 45  1  0
 45 46  2  3
 46 47  1  0
 47 48  2  3
 48 43  1  0
 49 50  1  0
 50 51  1  0
 51 52  1  0
 52 53  1  0
 53 54  1  0
 54 55  1  0
 55 50  1  0
 53 56  1  0
 56 57  2  0
 56 58  1  0
 58 59  2  3
 59 60  1  0
 60 61  2  3
 61 62  1  0
 62 63  2  3
 63 58  1  0
 61 64  1  0
 64 65  2  3
 65 66  1  0
 66 67  2  3
 67 60  1  0
 66 68  1  0
 68 69  2  3
 69 70  1  0
 70 71  2  3
 71 72  1  0
 72 73  2  3
 73 68  1  0
 65 74  1  0
 74 75  2  3
 75 76  1  0
 76 77  2  3
 77 78  1  0
 78 79  2  3
 79 74  1  0
 77 80  1  0
 80 81  1  0
 81 82  1  0
 82 83  1  0
 83 84  1  0
 84 85  1  0
 85 86  1  0
 86 81  1  0
 84 87  1  0
 87 88  1  0
 88 89  2  3
 89 90  1  0
 90 91  2  3
 91 92  1  0
 92 93  2  3
 93 88  1  0
 93 94  1  0
 94 95  1  0
 95 87  1  0
 95 96  2  0
M  END
> <name>
UTKinase_V5

> <id>
28167

> <plate>
Kinase v5-1

> <well>
B03

> <supplier_cmpd_name>
124029

> <ctcr_id>
7002

> <supplier_cmpd_id>
EMD 124029

> <smiles>
CN1CCN(CC1)C(=O)C2=CC3=C(C=C2)N=C(C(=N3)C4=CC=C(C=C4)CN5CCC(CC5)N6C7=CC=CC=C7NC6=O)C8=CC=CC=C8.CN1CCN(CC1)C(=O)C2=CC3=C(C=C2)N=C(C(=N3)C4=CC=CC=C4)C5=CC=C(C=C5)CN6CCC(CC6)N7C8=CC=CC=C8NC7=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"EMD 124029",124029}

> <pdid>

> <targets>
{"Akt Inhibitor XII",Isozyme-Selective,Akti-2}

> <classes>
{}

> <pubchem_cids>
{25020796}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 30  0  0  0  0            999 V2000
    3.1882    2.6402    0.0000 O   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 N   0  0
    2.7248   -1.2135    0.0000 C   0  0
    3.1882   -2.6401    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.4135    4.4923    0.0000 C   0  0
   -1.5318    5.7059    0.0000 C   0  0
   -0.0400    5.5491    0.0000 C   0  0
    0.5701    4.1788    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.4134   -4.4924    0.0000 C   0  0
   -1.5318   -5.7059    0.0000 C   0  0
   -0.0400   -5.5491    0.0000 C   0  0
    0.5701   -4.1788    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  8  1  0
 16 11  1  0
  9 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 24 25  1  0
 25  6  1  0
 25 17  2  0
M  END
> <name>
UTKinase_V5

> <id>
28168

> <plate>
Kinase v5-1

> <well>
B05

> <supplier_cmpd_name>
181305

> <ctcr_id>
1117

> <supplier_cmpd_id>
EMD 181305

> <smiles>
O=C1NC(=O)c2c1c3c([nH]c4ccccc34)c5[nH]c6ccccc6c25

> <pd_targets>
{CCNB1,CCNB2,CCNB3,CDK1,KMT2A,MEN1,MAPT,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,CCNE1,CCNE2,CDK2,CCND1,CDK4,PRKACA,PRKACB,PRKACG,CCNA2,CAMK2A,CAMK2B,CAMK2D,CAMK2G,CDK5,CDK5R1
}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein",Kinase,Reader,Protease,"Protein Kinase",Bromodomain,"Cysteine protease","CMGC protein kinase group","AGC protein kinase group","Cysteine protea
se CA clan","CAMK protein kinase group","CMGC protein kinase CDK family","AGC protein kinase PKC family","Cysteine protease C1A family","AGC protein kinase PKA family","CAMK protein kinase CAMK2 famil
y","CMGC protein kinase CDC2 subfamily","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Protein kinase C (PKC) family","Protein kinase A (PKA) family","Delta subfamily"}

> <pathway_reactome>
{"Neuronal System","Signal Transduction","Cell Cycle","Transmission across Chemical Synapses","Signaling by GPCR",Mitotic,"Neurotransmitter receptors and postsynaptic signal transmission","GPCR downst
ream signalling","Mitotic G2-G2/M phases","Activation of NMDA receptors and postsynaptic events","G alpha (i) signalling events","G2/M Transition","Post NMDA receptor activation events","Visual photot
ransduction","Centrosome maturation","Activation of AMPK downstream of NMDARs","The phototransduction cascade","Loss of proteins required for interphase microtubule organization from the centrosome",I
nactivation,"recovery and regulation of the phototransduction cascade","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{CCND1,CDK4}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{"arcyriaflavin a",118458-54-1,118458541,"12,13-Dihydro-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione","12,13Dihydro5Hindolo(2,3a)pyrrolo(3,4c)carbazole5,7(6H)dione",CHEMBL268368,LSM-3627,LSM3
627,"Arcyriaflavin A, Synthetic",arcyriaflavin-a,arcyriaflavina,"STAUROSPORINE AGLYCON",BDBM2672,SCHEMBL8124103,CHEBI:93276,DTXSID5041613,2457,"EMD 181305","Arcyriaflavin A",181305}

> <pdid>
PD038554

> <targets>
{"Cyclin-dependent Kinase",cdk,"Arcyriaflavin A",Synthetic}

> <classes>
{}

> <pubchem_cids>
{5327723}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 23  0  0  0  0            999 V2000
    4.6379    5.2745    0.0000 Br  0  0
    4.3480    3.8028    0.0000 C   0  0
    5.4777    2.8159    0.0000 C   0  0
    5.1878    1.3442    0.0000 C   0  0
    3.7691    0.8603    0.0000 C   0  0
    3.1796   -0.5190    0.0000 N   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.5242    2.0130    0.0000 O   0  0
   -1.6852   -0.3847    0.0000 N   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.5000   -2.8577    0.0000 C   0  0
   -0.7500   -4.1567    0.0000 C   0  0
    0.7500   -4.1567    0.0000 C   0  0
    1.5000   -2.8577    0.0000 N   0  0
    0.7500   -1.5574    0.0000 C   0  0
    2.6395    1.8472    0.0000 C   0  0
    2.9286    3.3180    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  7  1  0
 18 13  1  0
  8 19  1  0
 19  5  1  0
 19 20  2  0
 20  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28169

> <plate>
Kinase v5-1

> <well>
B07

> <supplier_cmpd_name>
191500

> <ctcr_id>
2174

> <supplier_cmpd_id>
EMD 191500

> <smiles>
Brc1ccc2[nH]c3c(CC(=O)Nc4cccnc34)c2c1

> <pd_targets>
{GSK3A,CDK1,GSK3B,CCNB1,CCNB2,CCNB3,CSNK2A1,ABL1,PIM1,FLT4,CDK5,LCK,CDK5R1,CDK2,FYN,DYRK1A}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","TK protein kinase group","CAMK protein kinase group","CMGC protein kinase GSK family","CMGC protein kinase CDK
 family","Other protein kinase CK2 family","Tyrosine protein kinase Abl family","CAMK protein kinase PIM family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src family","CMGC prote
in kinase DYRK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily","Tyrosine protein kinase SrcA","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Glycogen syntha
se kinase (GSK) family","Cyclin-dependent kinase (CDK) family","Other protein kinases","TK: Tyrosine kinase","PIM family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family"
,"GSK subfamily","CDK1 subfamily","Casein kinase 2 (CK2) family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","CDK5 subfamily","Dyrk1 subfamily","Abl family","Type IV RTK
s: VEGF (vascular endothelial growth factor) receptor family","Src family"}

> <pathway_reactome>
{Disease,"Cell Cycle","Gene expression (Transcription)","Signal Transduction","Infectious disease",Mitotic,"RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors
 and second messengers","Signaling by Receptor Tyrosine Kinases","SARS-CoV Infections","Regulation of mitotic cell cycle","Generic Transcription Pathway","Leishmania infection","FLT3 signaling in dise
ase","Signaling by VEGF","HIV Infection","Mitotic G1 phase and G1/S transition","SARS-CoV-1 Infection","APC/C-mediated degradation of cell cycle proteins","Transcriptional Regulation by TP53","Parasit
e infection","Signaling by FLT3 ITD and TKD mutants","VEGF ligand-receptor interactions","Host Interactions of HIV factors","G0 and Early G1","SARS-CoV-1 Genome Replication and Transcription","Activat
ion of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity","Leishmania phagocytosis","STAT5 activation downstream of FLT3 ITD mutants","VEGF binds to VEGFR le
ading to receptor dimerization","The role of Nef in HIV-1 replication and disease pathogenesis","Replication of the SARS-CoV-1 genome","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulatio
n of TP53 Activity through Phosphorylation","FCGR3A-mediated phagocytosis","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Regulation of TP53 Expressi
on and Degradation","Nef and signal transduction","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Nef Mediated CD4 Down-regulation","Regulati
on of TP53 Degradation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{CCNB1,CDK1,CDK5,GSK3B}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{1-Azakenpaullone,1Azakenpaullone,676596-65-9,676596659,azakenpaullone,1-AKP,1AKP,"9-bromo-7,12-dihydropyrido(3',2':2,3)azepino(4,5-b)indol-6(5H)-one","9bromo7,12dihydropyrido(3',2':2,3)azepino(4,5b)i
ndol6(5H)one",C15H10BrN3O,"9-bromo-7,12-dihydro-pyrido(3',2':2,3)azepino(4,5-b)indol-6(5H)-one",Kinome_3492,Kinome3492,Kinome-3492,"Kinome 3492",SCHEMBL378920,BDBM7497,CHEMBL336961,"EMD 191500",191500
}

> <pdid>
PD010396

> <targets>
{GSK-3,1-Azakenpaullone}

> <classes>
{}

> <pubchem_cids>
{6538897}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 33  0  0  0  0            999 V2000
   12.6969   -3.2763    0.0000 H   0  3
   10.1969   -3.2763    0.0000 Cl  0  5
   -0.7603   -8.0518    0.0000 N   0  0
   -1.2256   -6.6258    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.2559   -4.6520    0.0000 C   0  0
    5.8646   -6.1001    0.0000 N   0  0
    4.3672   -6.1750    0.0000 C   0  0
    3.4207   -7.3387    0.0000 C   0  0
    1.9397   -7.1008    0.0000 C   0  0
    1.4052   -5.6993    0.0000 C   0  0
    2.3517   -4.5356    0.0000 C   0  0
    3.8327   -4.7735    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  7  1  0
 15 10  1  0
  9 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 16  1  0
 21 22  2  0
 17 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 23  1  0
 31 26  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28170

> <plate>
Kinase v5-1

> <well>
B09

> <supplier_cmpd_name>
203294

> <ctcr_id>
4498

> <supplier_cmpd_id>
EMD 203294

> <smiles>
[H+].[Cl-].NCCCn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45

> <pd_targets>
{PHKA1,CAMK2D,PRKACA,CCND1,CDK4,PRKACB,PRKACG}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","AGC protein kinase group","CAMK protein kinase CAMK2 family","AGC protein kinase PKA family","CMGC protein kinase group"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC families","CAMK2 family","Protein kinase A (PKA) family"}

> <pathway_reactome>
{"Neuronal System","Cell Cycle","Transmission across Chemical Synapses",Mitotic,"Neurotransmitter receptors and postsynaptic signal transmission","Mitotic G2-G2/M phases","Activation of NMDA receptors
 and postsynaptic events","G2/M Transition","Post NMDA receptor activation events","Centrosome maturation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Loss of p
roteins required for interphase microtubule organization from the centrosome","Ras activation upon Ca2+ influx through NMDA receptor","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SCHEMBL16371182,HMS3229B09,"Bisindolylmaleimide III hydrochloride","2-(1-(3-Aminopropyl)-1H-indol-3-yl)-3-(1H-indol-3-yl)maleimide, HCl","2(1(3Aminopropyl)1Hindol3yl)3(1Hindol3yl)maleimide, HCl","EMD
 203294",203294}

> <pdid>
PD005168

> <targets>
{"Bisindolylmaleimide III",Hydrochloride}

> <classes>
{}

> <pubchem_cids>
{16760314}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 30  0  0  0  0            999 V2000
   -4.3546   -5.3029    0.0000 C   0  0
   -2.8675   -5.1069    0.0000 N   0  0
   -1.8348   -6.1949    0.0000 C   0  0
   -2.1080   -7.6698    0.0000 O   0  0
   -0.4810   -5.5489    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1519   -3.7886    0.0000 C   0  0
   -2.7876   -2.4300    0.0000 O   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.8424   -6.2567    0.0000 C   0  0
    0.9009   -7.7438    0.0000 C   0  0
    2.3506   -8.1289    0.0000 N   0  0
    3.1642   -6.8696    0.0000 C   0  0
    4.6452   -6.6317    0.0000 C   0  0
    5.1797   -5.2302    0.0000 C   0  0
    4.2332   -4.0665    0.0000 C   0  0
    2.7522   -4.3044    0.0000 C   0  0
    2.2176   -5.7060    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  3
  6  7  1  0
  7  2  1  0
  7  8  2  0
  6  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17  9  1  0
 17 12  1  0
  5 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 18  1  0
 26 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28171

> <plate>
Kinase v5-1

> <well>
B11

> <supplier_cmpd_name>
203303

> <ctcr_id>
5600

> <supplier_cmpd_id>
EMD 203303

> <smiles>
CN1C(=O)C(=C(C1=O)c2c[nH]c3ccccc23)c4c[nH]c5ccccc45

> <pd_targets>
{SIRT1,SIRT2}

> <pathway_gtopdb>
{"Epigenetic regulator",Eraser,"Histone deacetylase","HDAC class III"}

> <pathway_chembl>
{Enzymes,"Chromatin modifying enzymes","3.5.1.- Histone deacetylases (HDACs)"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","M Phase","FOXO-mediated transcription","Mitotic Metaphase and Anaphase","Regu
lation of FOXO transcriptional activity by acetylation","Mitotic Anaphase","Nuclear Envelope (NE) Reassembly","Initiation of Nuclear Envelope (NE) Reformation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"bisindolylmaleimide v",113963-68-1,113963681,"113963 68 1","1-Methyl-3,4-bis(3-indolyl)maleimide","1Methyl3,4bis(3indolyl)maleimide","1 Methyl 3,4 bis(3 indolyl)maleimide","3,4-di(1H-indol-3-yl)-1-m
ethyl-1H-pyrrole-2,5-dione","3,4di(1Hindol3yl)1methyl1Hpyrrole2,5dione",3,4di(1Hindol3yl)1me,"EMD 203303",203303}

> <pdid>
PD021437

> <targets>
{"Bisindolylmaleimide V"}

> <classes>
{}

> <pubchem_cids>
{2400}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 C   0  0
    0.0079    7.5003    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
    1.3070    9.7511    0.0000 C   0  0
    2.6049   10.5032    0.0000 C   0  0
    2.6025   12.0032    0.0000 C   0  0
    1.3023   12.7512    0.0000 C   0  0
    0.0045   11.9991    0.0000 C   0  0
    0.0068   10.4991    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
  9 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 27 31  1  0
 31 24  1  0
 31 32  2  0
 32  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28172

> <plate>
Kinase v5-1

> <well>
B13

> <supplier_cmpd_name>
203881

> <ctcr_id>
4925

> <supplier_cmpd_id>
EMD 203881

> <smiles>
CCC(CO)Nc1nc(NCc2ccc(cc2)c3ccccn3)c4ncn(C(C)C)c4n1

> <pd_targets>
{CDK1,GSK3-BETA,GSK3A,CDK5,CCNA2,CDK2,REP,CCNB1,CCND1,CDK4,CCNE1,CCNH,CDK7,MNAT1,CCNT1,CDK9,CDK5R1,DYRK1A}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase GSK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5
 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase DYRK family","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Kinases (EC 2.7.x.x)","Anti-infective targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Viral protein targets","Cyclin-dependent kinase (CDK) family","Coronav
irus (CoV) proteins","CDK1 subfamily","CDK5 subfamily","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Dyrk1 subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Disease,Mitotic,"RNA Polymerase II Transcription","Infectious disease","Regulation of mitotic cell cycle","Generic Transcription Pathway","SARS-CoV Infe
ctions","APC/C-mediated degradation of cell cycle proteins","Transcriptional Regulation by TP53","SARS-CoV-2 Infection","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","
Regulation of TP53 Activity","SARS-CoV-2 Genome Replication and Transcription","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Phosphorylation","Replication
 of the SARS-CoV-2 genome","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Mitotic G1 
phase and G1/S transition","G0 and Early G1"}

> <broad_targets>
{CCNA2}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{294646-77-8,294646778,SCHEMBL13001905,CR8,441054-85-9,441054859,"EMD 203882","EMD 203881",203882,203881}

> <pdid>
PD004376

> <targets>
{CR8,(S)-Isomer,(R)-Isomer}

> <classes>
{}

> <pubchem_cids>
{21362564}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 C   0  0
    0.0079    7.5003    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
    1.3070    9.7511    0.0000 C   0  0
    2.6049   10.5032    0.0000 C   0  0
    2.6025   12.0032    0.0000 C   0  0
    1.3023   12.7512    0.0000 C   0  0
    0.0045   11.9991    0.0000 C   0  0
    0.0068   10.4991    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
  9 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 27 31  1  0
 31 24  1  0
 31 32  2  0
 32  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28173

> <plate>
Kinase v5-1

> <well>
B15

> <supplier_cmpd_name>
203882

> <ctcr_id>
4925

> <supplier_cmpd_id>
EMD 203882

> <smiles>
CCC(CO)Nc1nc(NCc2ccc(cc2)c3ccccn3)c4ncn(C(C)C)c4n1

> <pd_targets>
{CDK1,GSK3-BETA,GSK3A,CDK5,CCNA2,CDK2,REP,CCNB1,CCND1,CDK4,CCNE1,CCNH,CDK7,MNAT1,CCNT1,CDK9,CDK5R1,DYRK1A}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase GSK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5
 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase DYRK family","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Kinases (EC 2.7.x.x)","Anti-infective targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Viral protein targets","Cyclin-dependent kinase (CDK) family","Coronav
irus (CoV) proteins","CDK1 subfamily","CDK5 subfamily","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Dyrk1 subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Disease,Mitotic,"RNA Polymerase II Transcription","Infectious disease","Regulation of mitotic cell cycle","Generic Transcription Pathway","SARS-CoV Infe
ctions","APC/C-mediated degradation of cell cycle proteins","Transcriptional Regulation by TP53","SARS-CoV-2 Infection","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","
Regulation of TP53 Activity","SARS-CoV-2 Genome Replication and Transcription","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Phosphorylation","Replication
 of the SARS-CoV-2 genome","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Mitotic G1 
phase and G1/S transition","G0 and Early G1"}

> <broad_targets>
{CCNA2}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{294646-77-8,294646778,SCHEMBL13001905,CR8,441054-85-9,441054859,"EMD 203882","EMD 203881",203882,203881}

> <pdid>
PD004376

> <targets>
{CR8,(S)-Isomer,(R)-Isomer}

> <classes>
{}

> <pubchem_cids>
{21362564}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 32  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8933    3.7570    0.0000 C   0  0
    3.8912    5.2578    0.0000 C   0  0
    5.1894    6.0109    0.0000 C   0  0
    5.1872    7.5118    0.0000 C   0  0
    6.4854    8.2649    0.0000 C   0  0
    6.4833    9.7657    0.0000 N   0  0
    7.7815   10.5188    0.0000 C   0  0
    9.0818    9.7710    0.0000 O   0  0
    7.7793   12.0196    0.0000 O   0  0
    9.0775   12.7727    0.0000 C   0  0
    9.0754   14.2727    0.0000 C   0  0
   10.3754   13.5248    0.0000 C   0  0
   10.3779   12.0250    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4983    0.7413    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 20 23  1  0
  8 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 25 30  1  0
 30 31  2  0
 31  4  1  0
 31  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28174

> <plate>
Kinase v5-1

> <well>
B17

> <supplier_cmpd_name>
208922

> <ctcr_id>
6871

> <supplier_cmpd_id>
EMD 208922

> <smiles>
CC(C)n1cnc2c(NCCCCCCNC(=O)OC(C)(C)C)nc(NCCO)nc12

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{CK59,"CK 59",926319-75-7,926319757,CHEMBL3185811,CK-59,HMS3229B17,NCGC00347910-01,NCGC0034791001,"EMD 208922",208922}

> <pdid>
PD015781

> <targets>
{"CaMKII Inhibitor",CK59}

> <classes>
{}

> <pubchem_cids>
{25021162}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    5.2311   -3.4009    0.0000 O   0  0
    3.8056   -3.8679    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    1.8372   -5.2877    0.0000 C   0  0
    0.9498   -6.4949    0.0000 N   0  0
   -0.5420   -6.3307    0.0000 C   0  0
   -1.4309   -7.5400    0.0000 C   0  0
   -2.9180   -7.5171    0.0000 S   0  0
   -3.3865   -8.9421    0.0000 C   0  0
   -2.1761   -9.8280    0.0000 C   0  0
   -0.9594   -8.9505    0.0000 C   0  0
    1.3786   -3.8595    0.0000 S   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  7  2  0
  4 12  1  0
 12 13  1  0
 13  2  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 18  1  0
 23 24  2  0
 24 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28175

> <plate>
Kinase v5-1

> <well>
B19

> <supplier_cmpd_name>
217699

> <ctcr_id>
7670

> <supplier_cmpd_id>
EMD 217699

> <smiles>
O=C\1N=C(NCc2sccc2)SC1=C\c3ccc4ncccc4c3

> <pd_targets>
{CDK1,PRKCD,CLK2,CLK1,MAPK1,CDK2,DYRK1A,GSK3A,GSK3B,CCNA2,AURKA,CDK5,CDK5R1,CCNT1,CDK9,CCNB1,CCNE1,AURKB,CCNH,CDK7,MNAT1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","AGC protein kinase group","Other protein kinase group","CMGC protein kinase CDK family","AGC protein kinase PKC family","CMGC protein kinas
e CLK family","CMGC protein kinase MAPK family","CMGC protein kinase DYRK family","CMGC protein kinase GSK family","Other protein kinase AUR family","CMGC protein kinase CDC2 subfamily","AGC protein k
inase PKC delta subfamily","CMGC protein kinase ERK1","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK5 subfamil
y"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","Receptor kinases","Cyclin-dependent kinase (CD
K) family","Protein kinase C (PKC) family","CLK family","Mitogen-activated protein kinases (MAP kinases)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Other protein 
kinases","CDK1 subfamily","Delta subfamily","ERK subfamily","Dyrk1 subfamily","Aurora kinase (Aur) family","CDK5 subfamily"}

> <pathway_reactome>
{"Cell Cycle","Signal Transduction","Immune System","Gene expression (Transcription)",Mitotic,"Intracellular signaling by second messengers","Innate Immune System","RNA Polymerase II Transcription","R
egulation of mitotic cell cycle","DAG and IP3 signaling","Toll-like Receptor Cascades","Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","M Phase","APC/C-mediated degradation of c
ell cycle proteins","CaM pathway","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional Regulation by TP53","G0 and Early G1","Mitotic Metaphase and Anaphase","Activation of APC/C and APC/C:Cdc20 med
iated degradation of mitotic proteins","Calmodulin induced events","MyD88 cascade initiated on plasma membrane","Regulation of TP53 Activity","Mitotic Anaphase","APC/C:Cdc20 mediated degradation of mi
totic proteins","MAP kinase activation","Regulation of TP53 Expression and Degradation","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids","APC:Cdc20 mediated degr
adation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Cdc20:Phospho-APC/C mediated 
degradation of Cyclin A","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{CDK1}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{T2356,"EMD 217699","Ro 3306",217699}

> <pdid>
PD012836

> <targets>
{CDK}

> <classes>
{}

> <pubchem_cids>
{11631681}

$$$$
UTKinase_V5
  SciTegic11012413002D

 16 18  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5536   -4.4230    0.0000 C   0  0
   -4.0444   -4.5346    0.0000 C   0  0
   -4.6946   -5.8864    0.0000 C   0  0
   -3.8489   -7.1253    0.0000 N   0  0
   -2.3532   -7.0124    0.0000 C   0  0
   -1.7031   -5.6606    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10  2  1  0
 10  6  2  0
  8 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28176

> <plate>
Kinase v5-1

> <well>
B21

> <supplier_cmpd_name>
217707

> <ctcr_id>
2552

> <supplier_cmpd_id>
EMD 217707

> <smiles>
O=C1NCCc2[nH]c(cc12)c3ccncc3

> <pd_targets>
{ROCK1,MAPK12,PRKCQ,PRKD2,PKN2,GSK3B,CDK2,PLK1,SLK,PRKCD,RPS6KB1,HIPK4,ACVR1,CDK8,CDK1,CDC7,RPS6KA4,MAPKAPK2,MAPK13,MAPKAPK3,RPS6KA5,CDK9,CHEK2,PRKACA,MKNK2,PRKG1,CSNK2A1,GSK3A,CDK5,CDC42BPA,PLK4,PASK
,DAPK3,MINK1,DYRK3,DYRK4,ROCK2,JAK3,MARK2,MKNK1,CSNK1G2,BRSK1,RPS6KA3,PRKG2,CLK2,TAOK1,CSNK1D,NEK4,CSNK1G1,CLK4,MAPK1,PRKCZ,CSNK1G3,PLK3,SGK2,LRRK2,STK17A,PRKX,IRAK4,PIM3,PBK,MAP4K2,PRKD3,HIPK2,MAPKAP
K5,AKT1,DYRK1A,DYRK1B,IRAK1,CSNK1A1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","CMGC protein kinase group","CAMK protein kinase group","Other protein kinase group","STE protein kinase group","TKL protein kinase group","T
K protein kinase group","CK1 protein kinase group","AGC protein kinase DMPK family","CMGC protein kinase MAPK family","AGC protein kinase PKC family","CAMK protein kinase PKD family","AGC protein kina
se PKN family","CMGC protein kinase GSK family","CMGC protein kinase CDK family","Other protein kinase PLK family","STE protein kinase STE20 family","AGC protein kinase RSK family","CMGC protein kinas
e DYRK family","TKL protein kinase STKR family","Other protein kinase CDC7 family","CAMK protein kinase MAPKAPK family","CAMK protein kinase RAD53 family","AGC protein kinase PKA family","AGC protein 
kinase PKG family","Other protein kinase CK2 family","CAMK protein kinase CAMK1 family","CAMK protein kinase DAPK family","Tyrosine protein kinase JakA family","CK1 protein kinase CK1 family","CMGC pr
otein kinase CLK family","Other protein kinase NEK family","AGC protein kinase SGK family","TKL protein kinase LRRK family","TKL protein kinase IRAK family","CAMK protein kinase PIM family","Other pro
tein kinase TOPK family","AGC protein kinase AKT family","AGC protein kinase ROCK subfamily","CMGC protein kinase p38 subfamily","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDC2 subf
amily","STE protein kinase SLK subfamily","AGC protein kinase p70 subfamily","CMGC protein kinase HIPK subfamily","TKL protein kinase STKR1","CMGC protein kinase CDK8 subfamily","AGC protein kinase MS
K subfamily","CAMK protein kinase MAPKAPK subfamily","CMGC protein kinase CDK9 subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase CDK5 subfamily","AGC protein kinase GEK subfamily","C
AMK protein kinase PASK subfamily","STE protein kinase MSN subfamily","CMGC protein kinase Dyrk2 subfamily","CAMK protein kinase MARK subfamily","CAMK protein kinase BRSK subfamily","AGC protein kinas
e RSK subfamily","STE protein kinase TAO subfamily","CMGC protein kinase ERK1","AGC protein kinase PKC iota subfamily","CK1 protein kinase CK1-g","STE protein kinase KHS subfamily","CMGC protein kinas
e Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kin
ases","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","DMPK family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase C (
PKC) family","Protein kinase D (PKD) family","Protein kinase N (PKN) family","Glycogen synthase kinase (GSK) family","Cyclin-dependent kinase (CDK) family","Other protein kinases","STE20 family","RSK 
family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","CAMK-like (CAMKL) family","Protein 
kinase A (PKA) family","Protein kinase G (PKG) family","Death-associated kinase (DAPK) family","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","CLK family","SGK family","PIM family","Akt (Protein
 kinase B","PKB) family","Rho kinase","p38 subfamily","Delta subfamily","GSK subfamily","CDK1 subfamily","Polo-like kinase (PLK) family","SLK subfamily","p70 subfamily","HIPK subfamily","Receptor seri
ne/threonine kinase (RSTK) family","CDK8 subfamily","CDC7 family","MSK subfamily","MAPKAPK subfamily","CDK9 subfamily","CHK1 subfamily","MKN subfamily","Casein kinase 2 (CK2) family","CDK5 subfamily",
"GEK subfamily","PASK subfamily","MSN subfamily","Dyrk2 subfamily","Dyrk1 subfamily","Non-receptor tyrosine kinases (nRTKs)","MARK subfamily","BRSK subfamily","RSK subfamily","TAO subfamily","NIMA (ne
ver in mitosis gene a)- related kinase (NEK) family","ERK subfamily","Iota subfamily","Leucine-rich repeat kinase (LRRK) family","Interleukin-1 receptor-associated kinase (IRAK) family","TOPK family",
"KHS subfamily","Type I receptor serine/threonine kinases","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction",Metabolism,Disease,"Gene expression (Transcription)","Cell Cycle","Immune System",Hemostasis,"Programmed Cell Death","Cellular responses to external stim
uli","Transport of small molecules","Nervous system development","Signaling by Receptor Tyrosine Kinases","Signaling by GPCR","Metabolism of lipids","Signaling by Rho GTPases","Infectious disease","RN
A Polymerase II Transcription",Mitotic,"Intracellular signaling by second messengers","MTOR signalling","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immun
e System","Platelet homeostasis",Apoptosis,"Cellular responses to stress","Cytokine Signaling in Immune system","MAPK family signaling cascades","Signaling by Nuclear Receptors","Ion channel transport
","Signaling by Non-Receptor Tyrosine Kinases","Axon guidance","Signaling by NTRKs","GPCR downstream signalling","Sphingolipid metabolism","RHO GTPase Effectors","SARS-CoV Infections","Generic Transcr
iption Pathway","Mitotic G2-G2/M phases","DAG and IP3 signaling","mTORC1-mediated signalling","Signaling by NOTCH1 in Cancer","Regulation of mitotic cell cycle","Mitotic G1 phase and G1/S transition",
"Toll-like Receptor Cascades","HIV Infection","Nitric oxide stimulates guanylate cyclase","Caspase activation via extrinsic apoptotic signalling pathway","Cellular Senescence","Signaling by Interleuki
ns","Signaling by FGFR","MAPK1/MAPK3 signaling","M Phase","ESR-mediated signaling","Stimuli-sensing channels","Signaling by PTK6","Leishmania infection","Signaling by WNT in cancer","Semaphorin intera
ctions","Signaling by NTRK1 (TRKA)","G alpha (i) signalling events","Sphingolipid de novo biosynthesis","RHO GTPases activate PKNs","SARS-CoV-1 Infection","Transcriptional Regulation by TP53","G2/M Tr
ansition","CaM pathway","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","APC/C-mediated degradation of cell cycle proteins","G1/S Transition","L1CAM interactions","Toll Like Receptor 5 (TLR5) C
ascade","HIV Life Cycle","cGMP effects","Caspase activation via Dependence Receptors in the absence of ligand","Oxidative Stress Induced Senescence","Interleukin-2 family signaling","Signaling by FGFR
4","RAF/MAP kinase cascade","Mitotic Metaphase and Anaphase","Extra-nuclear estrogen signaling","PTK6 promotes HIF1A stabilization","Leishmania parasite growth and survival","Toll Like Receptor 2 (TLR
2) Cascade","G0 and Early G1","Signaling by AMER1 mutants","Sema4D in semaphorin signaling","Signalling to ERKs","Visual phototransduction","SARS-CoV-1 Genome Replication and Transcription","Regulatio
n of TP53 Activity","Centrosome maturation","Calmodulin induced events","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic p
roteins","Activation of the pre-replicative complex","Recycling pathway of L1","MyD88 cascade initiated on plasma membrane","Late Phase of HIV Life Cycle","Interleukin-15 signaling","Negative regulati
on of FGFR4 signaling","RAS processing","Mitotic Anaphase","Estrogen-stimulated signaling through PRKCZ","Anti-inflammatory response favouring Leishmania parasite infection","Toll Like Receptor TLR6:T
LR2 Cascade","Truncations of AMER1 destabilize the destruction complex","Sema4D induced cell migration and growth-cone collapse","Signalling to RAS","The phototransduction cascade","Replication of the
 SARS-CoV-1 genome","Regulation of TP53 Expression and Degradation","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic
 proteins","MAP kinase activation","Transcription of the HIV genome","Regulation of TP53 Activity through Phosphorylation","Spry regulation of FGF signaling","Separation of Sister Chromatids","ADORA2B
 mediated anti-inflammatory cytokines production","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","p38MAPK events",Inactivation,"recovery and regulation of the phototransduction cascade","Regu
lation of TP53 Degradation","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","MAPK targets/ Nuclear even
ts mediated by MAP kinases","activated TAK1 mediates p38 MAPK activation","HIV Transcription Elongation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","CREB phosphorylation","Tat-mediated elo
ngation of the HIV-1 transcript","ERK/MAPK targets","Formation of HIV-1 elongation complex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
{CDK1,RPS6KB1}

> <broad_moa>
{"CDC inhibitor"}

> <synonyms>
{PHA-767491,PHA767491,845714-00-3,845714003,CAY10572,"PHA 767491","compound 8 (PMID: 17480064)","2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo(3,2-c)pyridin-4-one","2pyridin4yl1,5,6,7tetrahydropyrrolo(3,2c
)pyridin4one",PHA-767491A,PHA767491A,CAY10572(PHA-767491),CAY10572(PHA767491),"1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo(3,2-c)pyridin-4-one","1,5,6,7Tetrahydro2(4pyridinyl)4Hpyrrolo(3,2c)pyridin4
one",2-(pyrid,2(pyrid,T6940,S2742,"EMD 217707","PHA767491 HCl",217707}

> <pdid>
PD010690

> <targets>
{CDK,"Cdc7/Cdk9 Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{11715767}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    9.0964   -0.7661    0.0000 C   0  0
    7.7949   -1.5117    0.0000 O   0  0
    6.4972   -0.7578    0.0000 C   0  0
    5.1976   -1.5070    0.0000 C   0  0
    3.8990   -0.7562    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1884   -2.6409    0.0000 C   0  0
   -4.6234   -3.0602    0.0000 C   0  0
   -4.9781   -4.5176    0.0000 C   0  0
   -3.8933   -5.5536    0.0000 C   0  0
   -2.4537   -5.1320    0.0000 C   0  0
   -1.3661   -6.1662    0.0000 C   0  0
    0.0736   -5.7424    0.0000 C   0  0
    1.1612   -6.7766    0.0000 C   0  0
    1.8858   -7.4658    0.0000 N   0  0
   -2.0990   -3.6745    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    3.9001    0.7439    0.0000 C   0  0
    5.1996    1.4930    0.0000 C   0  0
    5.1975    2.9939    0.0000 O   0  0
    3.8979    3.7429    0.0000 C   0  0
    6.4981    0.7422    0.0000 C   0  0
    7.7999    1.4891    0.0000 O   0  0
    9.0974    0.7364    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  3  0
 18 23  2  0
 23 14  1  0
 13 24  1  0
 24 10  1  0
 24 25  2  0
 25  7  1  0
  5 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 27 30  2  0
 30  3  1  0
 30 31  1  0
 31 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28177

> <plate>
Kinase v5-1

> <well>
D03

> <supplier_cmpd_name>
218713

> <ctcr_id>
5356

> <supplier_cmpd_id>
EMD 218713

> <smiles>
COc1cc(Nc2ncc3ccn(c4cccc(CCC#N)c4)c3n2)cc(OC)c1OC

> <pd_targets>
{PTK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Fak family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Fak family"}

> <pathway_reactome>
{Disease,"Infectious disease","Leishmania infection","Parasite infection","Leishmania phagocytosis","FCGR3A-mediated phagocytosis"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Keratinocyte Differentiation Inducer",863598-09-8,863598098,CHEMBL206524,"Casein Kinase II Inhibitor IV",CK2-IN-1,CK2IN1,SCHEMBL12528899,DTXSID70466376,HMS3229D03,BDBM50184020,HY-111378,HY111378,CS-
0040257,CS0040257,JL2,"EMD 218713",218713}

> <pdid>
PD041908

> <targets>
{"Keratinocyte Differentiation Inducer","Casein Kinase"}

> <classes>
{Cell Cycle/DNA Damage,Stem Cell/Wnt}

> <pubchem_cids>
{11453158}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 25  0  0  0  0            999 V2000
    4.4165   -3.9867    0.0000 O   0  0
    4.8823   -2.5608    0.0000 C   0  0
    6.3501   -2.2517    0.0000 O   0  0
    3.8794   -1.4442    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.5701   -4.1788    0.0000 C   0  0
    0.0400   -5.5491    0.0000 C   0  0
    1.5318   -5.7059    0.0000 C   0  0
    2.4135   -4.4923    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 15 16  1  0
 16  6  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22  5  1  0
 22 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28178

> <plate>
Kinase v5-1

> <well>
D05

> <supplier_cmpd_name>
218714

> <ctcr_id>
245

> <supplier_cmpd_id>
EMD 218714

> <smiles>
OC(=O)Cc1c2NC(=O)c3ccccc3n2c4ccccc14

> <pd_targets>
{DYRK1A,CSNK2A1,CSNK2A2,CSNK2B,GSK3B,LCK,PRKACA,PRKACB,PRKACG}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","TK protein kinase group","AGC protein kinase group","CMGC protein kinase DYRK family","Other protein kinase CK
2 family","CMGC protein kinase GSK family","Tyrosine protein kinase Src family","AGC protein kinase PKA family","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK
) family","Other protein kinases","Glycogen synthase kinase (GSK) family","TK: Tyrosine kinase","Dyrk1 subfamily","Casein kinase 2 (CK2) family","GSK subfamily","Non-receptor tyrosine kinases (nRTKs)"
,"Src family"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Disease,Mitotic,"RNA Polymerase II Transcription","Infectious disease","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","SARS-CoV 
Infections","HIV Infection","G0 and Early G1","Transcriptional Regulation by TP53","SARS-CoV-1 Infection","Host Interactions of HIV factors","Regulation of TP53 Activity","SARS-CoV-1 Genome Replicatio
n and Transcription","The role of Nef in HIV-1 replication and disease pathogenesis","Regulation of TP53 Activity through Phosphorylation","Replication of the SARS-CoV-1 genome","Nef-mediates down mod
ulation of cell surface receptors by recruiting them to clathrin adapters","Nef Mediated CD4 Down-regulation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"(5-OXO-5,6-DIHYDRO-INDOLO(1,2-A)QUINAZOLIN-7-YL)-ACETIC ACID","(5OXO5,6DIHYDROINDOLO(1,2A)QUINAZOLIN7YL)ACETIC ACID",CGP-029482,CGP029482,CHEMBL92361,"2-(5-oxo-6H-indolo(1,2-a)quinazolin-7-yl)acetic
 acid","2(5oxo6Hindolo(1,2a)quinazolin7yl)acetic acid","(5-oxo-5,6-dihydroindolo(1,2-a)quinazolin-7-yl)acetic acid","(5oxo5,6dihydroindolo(1,2a)quinazolin7yl)acetic acid",1om1,SCHEMBL263731,BDBM11319,
HMS3229D05,HMS367,"EMD 218714",218714}

> <pdid>
PD008441

> <targets>
{"Casein Kinase II Inhibitor IV"}

> <classes>
{}

> <pubchem_cids>
{447682}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
   -5.7049   -9.6576    0.0000 N   0  0
   -4.2378   -9.9701    0.0000 S   0  0
   -3.7754  -11.3971    0.0000 O   0  0
   -5.2422  -11.0842    0.0000 O   0  0
   -3.2334   -8.8550    0.0000 C   0  0
   -1.7662   -9.1671    0.0000 C   0  0
   -0.7624   -8.0525    0.0000 C   0  0
   -1.2256   -6.6258    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 N   0  0
   -0.6890   -4.0818    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Br  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6928   -6.3138    0.0000 C   0  0
   -3.6967   -7.4283    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  2  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 11  1  0
 21 15  1  0
  8 22  1  0
 22 23  2  0
 23  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28179

> <plate>
Kinase v5-1

> <well>
D07

> <supplier_cmpd_name>
219445

> <ctcr_id>
215

> <supplier_cmpd_id>
EMD 219445

> <smiles>
N[S](=O)(=O)c1ccc(N\N=C2/C(=O)Nc3ccc(Br)cc23)cc1

> <pd_targets>
{CA2,CA9,CDK2,CA12,CDK1,CA1,CCNA2,CCNE1,CCND1,CDK4,CDK5,CDK5R1,CCNT1,CDK9,CCNB1,CCNH,CDK7,MNAT1}

> <pathway_gtopdb>
{Enzyme,Lyase,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK7 s
ubfamily"}

> <pathway_chembl>
{Enzymes,"Carbonic anhydrases","Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK1 subfamily"}

> <pathway_reactome>
{"Transport of small molecules","Cellular responses to external stimuli","Gene expression (Transcription)",Metabolism,"Cell Cycle","Immune System","O2/CO2 exchange in erythrocytes","Cellular responses
 to stress","RNA Polymerase II Transcription","Reversible hydration of carbon dioxide",Mitotic,"Cytokine Signaling in Immune system","Erythrocytes take up carbon dioxide and release oxygen","Cellular 
response to hypoxia","Generic Transcription Pathway","Regulation of mitotic cell cycle","Signaling by Interleukins","Regulation of gene expression by Hypoxia-inducible Factor","Transcriptional Regulat
ion by TP53","APC/C-mediated degradation of cell cycle proteins","Interleukin-12 family signaling","Regulation of TP53 Activity","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic pr
oteins","Interleukin-12 signaling","Regulation of TP53 Expression and Degradation","APC/C:Cdc20 mediated degradation of mitotic proteins","Gene and protein expression by JAK-STAT signaling after Inter
leukin-12 stimulation","Regulation of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradat
ion of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"EMD 219445",219445}

> <pdid>
PD003884

> <targets>
{"Cdk2 Inhibitor II"}

> <classes>
{}

> <pubchem_cids>
{5858639}

$$$$
UTKinase_V5
  SciTegic11012413002D

 19 19  0  0  0  0            999 V2000
    5.0987    2.9934    0.0000 Cl  0  0
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 C   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -5.2096    5.9863    0.0000 S   0  0
   -6.5058    5.2314    0.0000 N   0  0
   -5.2158    7.4863    0.0000 O   0  0
   -6.5116    6.7312    0.0000 O   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 10 13  1  0
 13 14  1  0
 13 15  2  0
 13 16  2  0
  5 17  2  0
 17 18  1  0
 18 19  2  0
 19  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28180

> <plate>
Kinase v5-1

> <well>
D09

> <supplier_cmpd_name>
219448

> <ctcr_id>
6152

> <supplier_cmpd_id>
EMD 219448

> <smiles>
Cl.Nc1cc(Nc2ccc(cc2)[S](N)(=O)=O)ncn1

> <pd_targets>
{CCNA2,CDK2,CCNE1,CDK5,CDK5R1,CCNB1,CDK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{21886-12-4,21886124,"PNU112455A (hydrochloride)",PNU112455A,"4-((6-Aminopyrimidin-4-yl)amino)benzenesulfonamide hydrochloride","4((6Aminopyrimidin4yl)amino)benzenesulfonamide hydrochloride","cdk2/5 i
nhibitor","4-((6-Amino-4-pyrimidinyl)amino)-benzenesulfonamide hydrochloride","4((6Amino4pyrimidinyl)amino)benzenesulfonamide hydrochloride",4-((6-aminopyrimidin-4-yl)amino)benzenesul,4((6aminopyrimid
in4yl)amino)benzenesul,"EMD 219448",219448}

> <pdid>
PD007101

> <targets>
{"Cdk2/5 Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{91980621,44721563,16760362}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8933    3.7570    0.0000 C   0  0
    5.1925    3.0071    0.0000 C   0  0
    6.4915    3.7571    0.0000 C   0  0
    6.4914    5.2571    0.0000 C   0  0
    5.1924    6.0071    0.0000 C   0  0
    3.8933    5.2570    0.0000 C   0  0
    2.5943    6.0070    0.0000 O   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4990    0.7409    0.0000 C   0  0
   -7.7996    1.4882    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 16 17  1  0
  8 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 19 25  1  0
 25 26  2  0
 26  4  1  0
 26  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28181

> <plate>
Kinase v5-1

> <well>
D11

> <supplier_cmpd_name>
219457

> <ctcr_id>
4912

> <supplier_cmpd_id>
EMD 219457

> <smiles>
CC(C)n1cnc2c(NCc3ccccc3O)nc(NCCCO)nc12

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{2-Hydroxybohemine,2Hydroxybohemine,"2 Hydroxybohemine",471270-60-7,471270607,"471270 60 7","Cdk Inhibitor, p35",CHEMBL419931,2-(((2-(3-hydroxypropylamino)-9-propan-2-ylpurin-6-yl)amino)methyl)phenol,
2(((2(3hydroxypropylamino)9propan2ylpurin6yl)amino)methyl)phenol,2(((2(3hydroxypropylamino)9propan2ylpurin6yl)amin,"EMD 219457",219457}

> <pdid>

> <targets>
{"Cdk Inhibitor",p35}

> <classes>
{}

> <pubchem_cids>
{4155347}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 25  0  0  0  0            999 V2000
   11.3231   -2.0750    0.0000 H   0  3
    8.8231   -2.0750    0.0000 Cl  0  5
    6.3226   -2.9205    0.0000 N   0  0
    5.2770   -1.8450    0.0000 C   0  0
    3.7923   -2.0588    0.0000 N   0  0
    3.1484   -0.7186    0.0000 C   0  0
    4.2056    0.3328    0.0000 C   0  0
    3.9834    1.8162    0.0000 O   0  0
    5.5324   -0.3669    0.0000 N   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 N   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -3.1476   -0.7184    0.0000 O   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.2135   -2.9844    0.0000 N   0  0
    0.0000   -3.8661    0.0000 C   0  0
    0.1561   -5.3568    0.0000 C   0  0
    1.5264   -5.9669    0.0000 C   0  0
    2.7399   -5.0852    0.0000 C   0  0
    2.5831   -3.5935    0.0000 C   0  0
    1.2135   -2.9844    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9  4  1  0
  6 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 10  1  0
 24 16  2  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28182

> <plate>
Kinase v5-1

> <well>
D13

> <supplier_cmpd_name>
220485

> <ctcr_id>
7678

> <supplier_cmpd_id>
EMD 220485

> <smiles>
[H+].[Cl-].NC1=NC(/C(=O)N1)=C2/CCNC(=O)c3[nH]c4ccccc4c23

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{220485,"EMD 220485"}

> <pdid>

> <targets>
{"Chk2 Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{16760370}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -5.1961   -3.0000    0.0000 C   0  0
   -5.1962   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  2  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28183

> <plate>
Kinase v5-1

> <well>
D15

> <supplier_cmpd_name>
234501

> <ctcr_id>
3616

> <supplier_cmpd_id>
EMD 234501

> <smiles>
O=C1C=C(N=C2N1C=Cc3ccccc23)N4CCOCC4

> <pd_targets>
{PRKDC,MTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Other PIKK family kinases","FRAP subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)","Innate Immune System","RNA Polymerase II Transcription","Cytosolic sensors of pathogen-associated DNA","Generic Transcription Pathway","STING mediat
ed induction of host immune responses","Transcriptional Regulation by TP53","IRF3-mediated induction of type I IFN","Regulation of TP53 Activity","Regulation of TP53 Expression and Degradation","Regul
ation of TP53 Degradation"}

> <broad_targets>
{MTOR,PRKDC}

> <broad_moa>
{"DNA dependent protein kinase inhibitor"}

> <synonyms>
{"Compound 401",168425-64-7,168425647,"2-morpholino-4H-pyrimido(2,1-a)isoquinolin-4-one","2morpholino4Hpyrimido(2,1a)isoquinolin4one","2-(morpholin-4-yl)pyrimido(2,1-a)isoquinolin-4-one","2(morpholin4
yl)pyrimido(2,1a)isoquinolin4one","2-(4-MORPHOLINYL)-4H-PYRIMIDO(2,1-A)ISOQUINOLIN-4-ONE","2(4MORPHOLINYL)4HPYRIMIDO(2,1A)ISOQUINOLIN4ONE",CHEMBL179242,4H-Pyrimido(2,4HPyrimido(2,1-a)isoquinolin-4-one
,1a)isoquinolin4one,2-(4-morph,2(4morph,T3586,3271,"EMD 234501",234501,"COMPOUND 401"}

> <pdid>
PD015722

> <targets>
{DNA-PK,"Compound 401"}

> <classes>
{}

> <pubchem_cids>
{10039361}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    4.2566    0.5871    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.8089   -4.6669    0.0000 N   0  0
    2.7343   -2.9815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
    0.0156   -5.9927    0.0000 N   0  3
    0.0234   -7.4927    0.0000 O   0  5
    1.3110   -5.2364    0.0000 O   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  7  2  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 18 20  1  0
 20 21  1  0
 20 22  2  0
 12 23  2  0
 23  8  1  0
M  CHG  2  20   1  21  -1
M  END
> <name>
UTKinase_V5

> <id>
28184

> <plate>
Kinase v5-1

> <well>
D17

> <supplier_cmpd_name>
238806

> <ctcr_id>
1421

> <supplier_cmpd_id>
EMD 238806

> <smiles>
Cc1nc(N)sc1c2ccnc(Nc3cccc(c3)[N+]([O-])=O)n2

> <pd_targets>
{CCNH,CDK7,CDK1,CDK4,CCNB1,CCNB2,CCNB3,CCND1,CDK9,CCNT1,AURKB,CCNA2,CDK2,GSK3B,AURKA,ABL1,ABL2,CCNE1,CCNE2,MNAT1,CDK5,CDK5R1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","TK protein kinase group","CMGC protein kinase CDK family","Other protein kinase AUR family","CMGC protein kina
se GSK family","Tyrosine protein kinase Abl family","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Cyclin-dependent kinase (CDK) family","Other protein kinases","Glyco
gen synthase kinase (GSK) family","TK: Tyrosine kinase","CDK1 subfamily","CDK7 subfamily","CDK4 subfamily","CDK9 subfamily","Aurora kinase (Aur) family","GSK subfamily","Non-receptor tyrosine kinases 
(nRTKs)","Abl family"}

> <pathway_reactome>
{"Cell Cycle",Disease,"Gene expression (Transcription)",Mitotic,"Infectious disease","RNA Polymerase II Transcription","Regulation of mitotic cell cycle","HIV Infection","Mitotic G1 phase and G1/S tra
nsition","M Phase","Generic Transcription Pathway","SARS-CoV Infections","Leishmania infection","APC/C-mediated degradation of cell cycle proteins","HIV Life Cycle","G1 Phase","Mitotic Metaphase and A
naphase","Transcriptional Regulation by TP53","SARS-CoV-1 Infection","Parasite infection","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Late Phase of HIV Life Cycle",
"Cyclin D associated events in G1","Mitotic Anaphase","Regulation of TP53 Activity","SARS-CoV-1 Genome Replication and Transcription","Leishmania phagocytosis","APC/C:Cdc20 mediated degradation of mit
otic proteins","Transcription of the HIV genome","Separation of Sister Chromatids","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-1 genome","Regulation of TP53 Activity t
hrough Phosphorylation","FCGR3A-mediated phagocytosis","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","HIV Transcription Elongation","Regulat
ion of TP53 Degradation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Cdk2/9 Inhibitor",(4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL)-(3-NITRO-PHENYL)-AMINE,(4(2AMINO4METHYLTHIAZOL5YL)PYRIMIDIN2YL)(3NITROPHENYL)AMINE,507487-89-0,507487890,CHEMBL298445,(4-(2-Amino
-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine,(4(2Amino4methylthiazol5yl)pyrimidin2yl)(3nitrophenyl)amine,CK7,1pxo,2wev,"CDK Inhibitor, 1",2c5p,BDBM8061,SCHEMBL136825,"EMD 238806",238806}

> <pdid>
PD007601

> <targets>
{"Cdk2/9 Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{447961}

$$$$
UTKinase_V5
  SciTegic11012413002D

 16 17  0  0  0  0            999 V2000
    5.5479   -1.6669    0.0000 N   0  0
    5.2447   -3.1359    0.0000 C   0  0
    6.2484   -4.2507    0.0000 N   0  0
    5.4984   -5.5497    0.0000 N   0  0
    4.0312   -5.2378    0.0000 C   0  0
    2.9105   -6.2349    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  2  2  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28185

> <plate>
Kinase v5-1

> <well>
D19

> <supplier_cmpd_name>
238811

> <ctcr_id>
3053

> <supplier_cmpd_id>
EMD 238811

> <smiles>
Nc1[nH]nc(N)c1N=Nc2ccc(O)cc2

> <pd_targets>
{CCNE1,CCNE2,CDK2,CCNA1,CCNA2,CCNH,CDK7,CDK9,RPS6KB1,RPS6KB2,CCND1,CDK4,CCNT1,CCNB1,CCNB2,CCNB3,CDK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","AGC protein kinase group","CMGC protein kinase CDK family","AGC protein kinase RSK family","CMGC protein kinase CDC2 subfamily","CMGC prote
in kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","AGC protein kinase p70 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK9 subfamily","CDK7 subfamily","CDK4 subfamily","CDK1 subfamily"}

> <pathway_reactome>
{Disease,"Cell Cycle","Gene expression (Transcription)","Infectious disease",Mitotic,"RNA Polymerase II Transcription","HIV Infection","Mitotic G1 phase and G1/S transition","Regulation of mitotic cel
l cycle","Generic Transcription Pathway","HIV Life Cycle","G1 Phase","APC/C-mediated degradation of cell cycle proteins","Transcriptional Regulation by TP53","Late Phase of HIV Life Cycle","Cyclin D a
ssociated events in G1","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity","Transcription of the HIV genome","APC/C:Cdc20 mediated degradation
 of mitotic proteins","Regulation of TP53 Expression and Degradation","HIV Transcription Elongation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle check
point","Regulation of TP53 Degradation","Tat-mediated elongation of the HIV-1 transcript","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Formation of HIV-1 elongation complex containing HIV-1
 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Cdk9 Inhibitor II",140651-18-9,140651189,CAN-508,CAN508,CAY10574,UNII-ZG0O47K626,UNIIZG0O47K626,CHEMBL215205,"4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol","4(3,5Diamino1Hpyrazol4ylazo)phenol","CAN 508
",ZG0O47K626,"Phenol, 4-((3,5-diamino-1H-pyrazol-4-yl)azo)-","Phenol, 4((3,5diamino1Hpyrazol4yl)azo)","CAN-508;CAN508;Cdk9 inhibitor II","CAN508;CAN508;Cdk9 inhibitor II",4-((3,4((3,5-diamin,5diamin,"
EMD 238811",238811}

> <pdid>
PD005515

> <targets>
{"Cdk9 Inhibitor II"}

> <classes>
{}

> <pubchem_cids>
{135398514}

$$$$
UTKinase_V5
  SciTegic11012413002D

 13 14  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
    0.0000   -4.5008    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10  5  1  0
 10 11  2  0
 11  2  1  0
 11 12  1  0
 12 13  3  0
M  END
> <name>
UTKinase_V5

> <id>
28186

> <plate>
Kinase v5-1

> <well>
D21

> <supplier_cmpd_name>
238900

> <ctcr_id>
4924

> <supplier_cmpd_id>
EMD 238900

> <smiles>
Cc1ncc2ccccc2c1C#N

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{4-cyano-3-methylisoquinoline,4cyano3methylisoquinoline,3-methylisoquinoline-4-carbonitrile,3methylisoquinoline4carbonitrile,161468-32-2,161468322,3-methyl-4-Isoquinolinecarbonitrile,3methyl4Isoquinol
inecarbonitrile,CMIQ,3-methyl-4-cyano-isoquinoline,3methyl4cyanoisoquinoline,SCHEMBL1773062,DTXSID80274328,CHEBI:113554,HMS3229D21,ZINC2391783,HSCI1_000275,HSCI1000275,HSCI1-000275,"HSCI1 000275",AKOS
006277445,MCULE-5,MCULE5,"EMD 238900",238900}

> <pdid>
PD015779

> <targets>
{4-Cyano-3-methylisoquinoline}

> <classes>
{}

> <pubchem_cids>
{1733}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    3.1882   -2.6401    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Br  0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    5.1065    0.0000    0.0000 O   0  0
    3.1884    2.6409    0.0000 C   0  0
    2.3979    3.8950    0.0000 C   0  0
    3.3714    5.0351    0.0000 C   0  0
    3.1753    6.5222    0.0000 C   0  0
    4.3651    7.4357    0.0000 C   0  0
    5.7510    6.8620    0.0000 C   0  0
    5.9472    5.3749    0.0000 C   0  0
    4.7574    4.4614    0.0000 C   0  0
    4.6405    2.9668    0.0000 N   0  0
    0.9031    3.9966    0.0000 N   0  0
    0.0661    2.7518    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  3
  8  3  1  0
  7  9  1  0
  4 10  1  0
 10 11  2  3
 11  2  1  0
 11 12  1  0
 10 13  1  0
 13 14  2  3
 14 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 15  1  0
 20 21  1  0
 21 13  1  0
 14 22  1  0
 22 23  2  0
M  END
> <name>
UTKinase_V5

> <id>
28187

> <plate>
Kinase v5-1

> <well>
F03

> <supplier_cmpd_name>
361556

> <ctcr_id>
6650

> <supplier_cmpd_id>
EMD 361556

> <smiles>
CN1C2=C(C=CC(=C2)Br)C(=C1O)C3=C(C4=CC=CC=C4N3)N=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MeBIO,667463-95-8,667463958,1-Methyl-BIO,1MethylBIO,"GSK-3 Inhibitor IX, Control, MeBIO","GSK3 Inhibitor IX, Control, MeBIO","(2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime","(2'Z,3'E)6Bromo1methylindi
rubin3'oxime",ME-6BIO,ME6BIO,CHEMBL173171,CHEMBL524052,SCHEMBL18837022,AOB5978,DTXSID00648022,HMS3229F03,(3Z)-6-bromo-3-(3-(hydroxyamino)indol-2-ylidene)-,(3Z)6bromo3(3(hydroxyamino)indol2ylidene),"EM
D 361556",361556}

> <pdid>

> <targets>
{Control,MeBIO,"GSK-3 Inhibitor IX"}

> <classes>
{}

> <pubchem_cids>
{135524908}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 40  0  0  0  0            999 V2000
    7.5973    0.5773    0.0000 H   0  3
    5.0973    0.5773    0.0000 Cl  0  5
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.1905    2.6376    0.0000 C   0  0
   -4.6589    2.9478    0.0000 C   0  0
   -5.6608    1.8315    0.0000 O   0  0
   -5.1253    4.3743    0.0000 C   0  0
   -6.5938    4.6845    0.0000 N   0  0
   -7.0600    6.1102    0.0000 C   0  0
   -7.5957    3.5682    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 C   0  0
   -6.2112    0.8473    0.0000 N   0  0
   -6.0543    2.3390    0.0000 C   0  0
   -7.5102    0.0972    0.0000 C   0  0
   -8.9356    0.5610    0.0000 C   0  0
  -10.0503   -0.4427    0.0000 C   0  0
   -9.7384   -1.9099    0.0000 C   0  0
   -8.3118   -2.3734    0.0000 C   0  0
   -7.1983   -1.3700    0.0000 C   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -5.1376   -4.2063    0.0000 C   0  0
   -6.5079   -4.8163    0.0000 O   0  0
   -3.8385   -4.9563    0.0000 N   0  0
   -2.7238   -3.9526    0.0000 C   0  0
   -1.2566   -4.2643    0.0000 O   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 14 16  1  0
  9 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 26 27  1  0
 27 18  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 29 31  1  0
 31 32  1  0
 32 33  2  0
 32 34  1  0
 34 28  1  0
 34 35  2  0
 35 17  1  0
 35 36  1  0
 36  8  1  0
 36 37  2  0
 37  5  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28188

> <plate>
Kinase v5-1

> <well>
F05

> <supplier_cmpd_name>
365252

> <ctcr_id>
4096

> <supplier_cmpd_id>
EMD 365252

> <smiles>
[H+].[Cl-].COc1ccc2n(CC(O)CN(C)C)c3c4n(C)c5ccccc5c4c6C(=O)NC(=O)c6c3c2c1

> <pd_targets>
{CHRM2,CHRM4,CHRM3,CHRM1,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCQ,PRKCZ,MYLK,PRKG1}

> <pathway_gtopdb>
{"Membrane receptor",Enzyme,"Family A G protein-coupled receptor",Kinase,"Small molecule receptor (family A GPCR)","Protein Kinase","Monoamine receptor","AGC protein kinase group","CAMK protein kinase
 group","Acetylcholine receptor","AGC protein kinase PKC family","CAMK protein kinase MLCK family","AGC protein kinase PKG family","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"G protein-coupled receptors","Kinases (EC 2.7.x.x)","Acetylcholine receptors (muscarinic)","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC famil
ies","Myosin Light Chain Kinase (MLCK) family","Protein kinase G (PKG) family"}

> <pathway_reactome>
{"Signal Transduction",Hemostasis,"Signaling by GPCR","Signaling by Rho GTPases","Platelet homeostasis","GPCR ligand binding","RHO GTPase Effectors","Nitric oxide stimulates guanylate cyclase","Class 
A/1 (Rhodopsin-like receptors)","RHO GTPases activate PAKs","cGMP effects","Amine ligand-binding receptors","Muscarinic acetylcholine receptors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"G&ouml; 7874, Hydrochloride",HMS3229F05,"EMD 365252",365252}

> <pdid>
PD051308

> <targets>
{"Gö 7874",Hydrochloride,"G? 7874"}

> <classes>
{}

> <pubchem_cids>
{11540703}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 19  0  0  0  0            999 V2000
   19.0990   -1.1250    0.0000 H   0  3
   16.5990   -1.1250    0.0000 H   0  3
   14.0990   -1.1250    0.0000 Cl  0  5
   11.5990   -1.1250    0.0000 Cl  0  5
    9.0983   -0.7529    0.0000 C   0  0
    7.7988   -1.5020    0.0000 N   0  0
    6.4990   -0.7516    0.0000 C   0  0
    5.1988   -1.5012    0.0000 C   0  0
    3.8990   -0.7508    0.0000 N   0  0
    2.5988   -1.5004    0.0000 S   0  0
    2.5983   -3.0004    0.0000 O   0  0
    3.8975   -2.2510    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  2  0
 10 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 13  1  0
 22 17  1  0
M  CHG  4   1   1   2   1   3  -1   4  -1
M  END
> <name>
UTKinase_V5

> <id>
28189

> <plate>
Kinase v5-1

> <well>
F07

> <supplier_cmpd_name>
371958

> <ctcr_id>
6217

> <supplier_cmpd_id>
EMD 371958

> <smiles>
[H+].[H+].[Cl-].[Cl-].CNCCN[S](=O)(=O)c1cccc2cnccc12

> <pd_targets>
{PRKACA,LMNA,PMP22,PFMRK,CYP3A4,GLA,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,NFKB1,CYP2D6,LEF,AKT2,MYLK,CNGA1}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein","Unclassified protein","Other cytosolic protein","Ion channel",Kinase,"Cytochrome P450",Hydrolase,Protease,"Voltage-gated ion channel","Protein Kinase","Cytochrome P450
 family 3","Cytochrome P450 family 2","Metallo protease","Cyclic nucleotide-regulated channel","AGC protein kinase group","CMGC protein kinase group","Cytochrome P450 family 3A","Cytochrome P450 famil
y 2D","Metallo protease MAE clan","CAMK protein kinase group","AGC protein kinase PKA family","CMGC protein kinase CDK family","Cytochrome P450 3A4","AGC protein kinase PKC family","Cytochrome P450 2D
6","Metallo protease M34 family","AGC protein kinase AKT family","CAMK protein kinase MLCK family","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels","Kinases (EC 2.7.x.x)","Cytochrome P450","Voltage-gated ion channels","AGC: Containing PKA",PKG,"PKC families","CYP3 family","CYP2 family: drug metabolising subset","CAMK: Calc
ium/calmodulin-dependent protein kinases","Cyclic nucleotide-regulated channels","Protein kinase A (PKA) family","Akt (Protein kinase B","PKB) family","Myosin Light Chain Kinase (MLCK) family"}

> <pathway_reactome>
{"Cell Cycle","Developmental Biology",Metabolism,"Immune System",Disease,"Signal Transduction",Mitotic,"Nervous system development","Metabolism of lipids","Cytokine Signaling in Immune system","Biolog
ical oxidations","Infectious disease","Signaling by Receptor Tyrosine Kinases","Signaling by Rho GTPases","Signaling by GPCR","Mitotic G2-G2/M phases","M Phase","EGR2 and SOX10-mediated initiation of 
Schwann cell myelination","Biosynthesis of specialized proresolving mediators (SPMs)","Sphingolipid metabolism","Signaling by Interleukins","Phase I - Functionalization of compounds","Uptake and actio
ns of bacterial toxins","Signaling by Insulin receptor","RHO GTPase Effectors","GPCR downstream signalling","G2/M Transition","Mitotic Metaphase and Anaphase","Biosynthesis of DHA-derived SPMs","Glyco
sphingolipid metabolism","Interleukin-1 family signaling","Cytochrome P450 - arranged by substrate type","Uptake and function of anthrax toxins","Insulin receptor signalling cascade","RHO GTPases acti
vate PAKs","G alpha (i) signalling events","Centrosome maturation","Mitotic Anaphase","Biosynthesis of maresins","Interleukin-1 signaling",Xenobiotics,"IRS-mediated signalling","Visual phototransducti
on","Loss of proteins required for interphase microtubule organization from the centrosome","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","MAP3K8 (TPL2)-dependent MAPK1/3 acti
vation","CYP2E1 reactions","PI3K Cascade","The phototransduction cascade","Loss of Nlp from mitotic centrosomes","Initiation of Nuclear Envelope (NE) Reformation","PKB-mediated events","Activation of 
the phototransduction cascade","PDE3B signalling"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"H-8 dihydrochloride","H8 dihydrochloride",113276-94-1,113276941,"H-8, Dihydrochloride","H8, Dihydrochloride","N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide dihydrochloride","N(2(Methylamino)eth
yl)5isoquinolinesulfonamide dihydrochloride",C12H15N3O2S.2HCl,"N-(2-(Methylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride","N(2(Methylamino)ethyl)isoquinoline5sulfonamide dihydrochloride",H8,N
-(2-(methy,N(2(methy,"EMD 371958",371958}

> <pdid>
PD005267

> <targets>
{H-8,Dihydrochloride}

> <classes>
{}

> <pubchem_cids>
{150584,74764572}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 21  0  0  0  0            999 V2000
   16.5009   -3.3772    0.0000 H   0  3
   14.0009   -3.3772    0.0000 H   0  3
   11.5009   -3.3772    0.0000 Cl  0  5
    9.0009   -3.3772    0.0000 Cl  0  5
    3.9024   -8.2541    0.0000 N   0  0
    5.2012   -7.5037    0.0000 C   0  0
    6.5002   -8.2537    0.0000 N   0  0
    5.2002   -6.0029    0.0000 N   0  0
    3.9005   -5.2525    0.0000 C   0  0
    3.8995   -3.7516    0.0000 C   0  0
    2.5997   -3.0012    0.0000 N   0  0
    2.5988   -1.5004    0.0000 S   0  0
    3.8982   -2.2498    0.0000 O   0  0
    3.8976   -0.7500    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  2  0
 12 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 15  1  0
 24 19  1  0
M  CHG  4   1   1   2   1   3  -1   4  -1
M  END
> <name>
UTKinase_V5

> <id>
28190

> <plate>
Kinase v5-1

> <well>
F09

> <supplier_cmpd_name>
371964

> <ctcr_id>
5468

> <supplier_cmpd_id>
EMD 371964

> <smiles>
[H+].[H+].[Cl-].[Cl-].NC(=N)NCCN[S](=O)(=O)c1cccc2cnccc12

> <pd_targets>
{CAMKK2,MAPK1,MELK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","CMGC protein kinase group","CAMK protein kinase group","Other protein kinase CAMKK family","CMGC protein kinase MAPK family","CAMK protein
 kinase CAMK1 family","Other protein kinase Meta subfamily","CMGC protein kinase ERK1","CAMK protein kinase MELK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein k
inases","Mitogen-activated protein kinases (MAP kinases)","CAMK-like (CAMKL) family","CAMKK family","ERK subfamily","MELK subfamily","Meta subfamily"}

> <pathway_reactome>
{"Neuronal System","Immune System","Transmission across Chemical Synapses","Innate Immune System","Neurotransmitter receptors and postsynaptic signal transmission","Toll-like Receptor Cascades","Activ
ation of NMDA receptors and postsynaptic events","Toll Like Receptor 5 (TLR5) Cascade","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","Activation of AMPK downstrea
m of NMDARs","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{}

> <broad_moa>
{"calcium channel blocker"}

> <synonyms>
{A1004?2HC,ha-1004,ha1004,"HA 1004 Dihydrochloride","HA-1004 HCl","HA1004 HCl",CHEMBL4080669,"N-(2-guanidinoethyl)-5-isoquinolinesulfonamide dihydrochloride","N(2guanidinoethyl)5isoquinolinesulfonamid
e dihydrochloride","92564-08-4 (2HCl),","92564084 (2HCl),",HA-1004DIHYDROCHLORIDE,HA1004DIHYDROCHLORIDE,"HA 1004, Dihydrochloride",BMK1-E1,BMK1E1,N-(2-Guanidinoethyl)-5-isoquinoline,N(2Guanidinoethyl)
5isoquinoline,EI-184,"EMD 371964","HA-1004 2HCl",371964,HA-1004?2HCl}

> <pdid>
PD062728

> <targets>
{"HA 1004",Dihydrochloride,PKA,PKG}

> <classes>
{}

> <pubchem_cids>
{16760499}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
    1.2947   -3.7531    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 N   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6060   -6.0003    0.0000 C   0  0
   -2.6060   -7.5003    0.0000 C   0  0
   -1.3070   -8.2503    0.0000 C   0  0
   -0.0080   -7.5003    0.0000 C   0  0
   -0.0079   -6.0003    0.0000 C   0  0
    1.2918   -8.2508    0.0000 C   0  0
    1.2927   -9.7508    0.0000 F   0  0
    2.5906   -7.5004    0.0000 F   0  0
    2.5911   -9.0002    0.0000 F   0  0
   -3.9058   -8.2507    0.0000 C   0  0
   -5.2053   -7.5015    0.0000 F   0  0
   -3.9054   -9.7507    0.0000 F   0  0
   -5.2045   -9.0013    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 16 18  1  0
 18 19  1  0
 18 20  1  0
 18 21  1  0
 14 22  1  0
 22 23  1  0
 22 24  1  0
 22 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28191

> <plate>
Kinase v5-1

> <well>
F11

> <supplier_cmpd_name>
401482

> <ctcr_id>
1228

> <supplier_cmpd_id>
EMD 401482

> <smiles>
Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F

> <pd_targets>
{TMPRSS4,RORC,KMT2A,MEN1,FLT3,KDR,IKBKB}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator",Protease,"Nuclear receptor",Reader,Kinase,"Serine protease","Nuclear hormone receptor subfamily 1",Bromodomain,"Protein Kinase","Nuclear hormone r
eceptor subfamily 1 group F","TK protein kinase group","Other protein kinase group","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase PDGFR family","Tyrosine protein kin
ase VEGFR family","Other protein kinase IKK family"}

> <pathway_chembl>
{Receptors,"Nuclear hormone receptors","Catalytic receptors","1F. Retinoic acid-related orphans","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kinases (RTKs)","IK
K family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Immune System","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Generic Transcription Pathwa
y","Signaling by Insulin receptor","Signaling by VEGF","Toll-like Receptor Cascades","Transcriptional regulation by RUNX3","Insulin receptor signalling cascade","VEGFA-VEGFR2 Pathway","Toll Like Recep
tor 4 (TLR4) Cascade","RUNX3 Regulates Immune Response and Cell Migration","IRS-mediated signalling","VEGFR2 mediated cell proliferation","MyD88-independent TLR4 cascade","PI3K Cascade","TRIF(TICAM1)-
mediated TLR4 signaling","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor","NFkB pathway inhibitor"}

> <synonyms>
{IMD-0354,IMD0354,978-62-1,978621,"IMD 0354","IKK-2 Inhibitor V","IKK2 Inhibitor V","N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide","N(3,5bis(trifluoromethyl)phenyl)5chloro2hydroxyben
zamide",TCMDC-125465,TCMDC125465,UNII-76145IS906,UNII76145IS906,CHEMBL536151,"N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide","N(3,5Bistrifluoromethylphenyl)5chloro2hydroxybenzamide",MF
CD00218820,761,T6141,2611,"EMD 401482",S2864,401482}

> <pdid>
PD010541

> <targets>
{IKK,"IKK-2 Inhibitor V"}

> <classes>
{}

> <pubchem_cids>
{5081913}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    6.1718    0.7439    0.0000 N   0  0
    7.0537   -0.4695    0.0000 C   0  0
    8.5454   -0.3119    0.0000 O   0  0
    6.4430   -1.8405    0.0000 N   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.8054   -4.6666    0.0000 C   0  0
    6.2966   -4.8284    0.0000 N   0  0
    3.9200   -5.8774    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9  5  2  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
  7 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28192

> <plate>
Kinase v5-1

> <well>
F13

> <supplier_cmpd_name>
401483

> <ctcr_id>
4405

> <supplier_cmpd_id>
EMD 401483

> <smiles>
NC(=O)Nc1sc(cc1C(N)=O)c2ccccc2

> <pd_targets>
{JAK2,JAK3,IKBKB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","Tyrosine protein kinase JakA family","Other protein kinase IKK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Non-receptor tyrosine kinases (nRTKs)","IKK family","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Cell Cycle","Immune System",Mitotic,"Cytokine Signaling in Immune system","Innate Immune System","Mitotic G1 phase and G1/S transition","Signaling by Interleukins","Toll-like Receptor Cascades","G1 
Phase","Interleukin-2 family signaling","Toll Like Receptor 4 (TLR4) Cascade","Cyclin D associated events in G1","Interleukin-15 signaling","MyD88-independent TLR4 cascade","TRIF(TICAM1)-mediated TLR4
 signaling","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"IKK-2 Inhibitor VI","IKK2 Inhibitor VI",354811-10-2,354811102,(5-Phenyl-2-ureido)thiophene-3-carboxamide,(5Phenyl2ureido)thiophene3carboxamide,5-Phenyl-2-Ureidothiophene-3-Carboxamide,5Phenyl2Ureido
thiophene3Carboxamide,2-(carbamoylamino)-5-phenylthiophene-3-carboxamide,2(carbamoylamino)5phenylthiophene3carboxamide,CHEMBL404609,2-((Aminocarbonyl)amino)-5-phenyl-3-thiophenecarboxamide,2((Aminocar
bonyl)amino)5phenyl3thiophenecarboxamide,IK1,IKK2,"EMD 401483",401483}

> <pdid>
PD017790

> <targets>
{"IKK-2 Inhibitor VI"}

> <classes>
{}

> <pubchem_cids>
{6419765}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 40  0  0  0  0            999 V2000
   -5.3306   -9.0124    0.0000 O   0  0
   -4.4785   -7.7779    0.0000 C   0  0
   -5.1224   -6.4222    0.0000 N   0  0
   -6.6174   -6.2989    0.0000 C   0  0
   -7.2581   -4.9427    0.0000 C   0  0
   -6.4040   -3.7096    0.0000 C   0  0
   -4.9090   -3.8329    0.0000 C   0  0
   -4.2683   -5.1891    0.0000 C   0  0
   -7.0450   -2.3527    0.0000 N   0  0
   -8.5092   -2.0913    0.0000 C   0  0
   -8.6971   -0.6032    0.0000 C   0  0
   -7.3398    0.0355    0.0000 C   0  0
   -6.3131   -1.0580    0.0000 C   0  0
   -2.9826   -7.8991    0.0000 C   0  0
   -2.3371   -9.2532    0.0000 C   0  0
   -0.8418   -9.3712    0.0000 C   0  0
    0.0082   -8.1352    0.0000 C   0  0
    1.5046   -8.2503    0.0000 N   0  0
    2.3532   -7.0124    0.0000 C   0  0
    3.8490   -7.1253    0.0000 N   0  0
    4.6946   -5.8864    0.0000 C   0  0
    4.0445   -4.5346    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.7031   -5.6606    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6374   -6.7812    0.0000 C   0  0
   -2.1327   -6.6631    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  6  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13  9  1  0
  2 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 23 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 32 33  1  0
 33 25  2  0
 17 34  1  0
 34 35  2  0
 35 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28193

> <plate>
Kinase v5-1

> <well>
F15

> <supplier_cmpd_name>
401486

> <ctcr_id>
2774

> <supplier_cmpd_id>
EMD 401486

> <smiles>
O=C(N1CCC(CC1)N2CCCC2)c3ccc(Nc4nccc(n4)c5sc6ccccc6c5)cc3

> <pd_targets>
{IKBKB,CHUK,RECQL,BLM,FFP,RORC,IKBKG,PRKCZ}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,Transferase,"Nuclear receptor","Protein Kinase","Nuclear hormone receptor subfamily 1","Other protein kinase group","Nuclear hormone receptor subfamily 1 group F"
,"AGC protein kinase group","Other protein kinase IKK family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKC family","AGC protein kinase PKC iota subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Receptor kinases","1F. Retinoic acid-related orphans","AGC: Containing PKA",PKG,"PKC families","Other prote
in kinases","Protein kinase C (PKC) family","IKK family","Iota subfamily"}

> <pathway_reactome>
{"Immune System","DNA Repair","Gene expression (Transcription)","Signal Transduction","Innate Immune System","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Signaling by Nuclear Re
ceptors","Toll-like Receptor Cascades","Homology Directed Repair","Generic Transcription Pathway","ESR-mediated signaling","Toll Like Receptor 4 (TLR4) Cascade","HDR through Homologous Recombination (
HRR) or Single Strand Annealing (SSA)","Transcriptional regulation by RUNX3","Extra-nuclear estrogen signaling","MyD88-independent TLR4 cascade","HDR through Homologous Recombination (HRR)","RUNX3 Reg
ulates Immune Response and Cell Migration","Estrogen-stimulated signaling through PRKCZ","TRIF(TICAM1)-mediated TLR4 signaling","Homologous DNA Pairing and Strand Exchange","IKK complex recruitment me
diated by RIP1","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor"}

> <synonyms>
{873225-46-8,873225468,"IKK Inhibitor VII",IKK-16,IKK16,"IKK 16","IKK-16 (IKK Inhibitor VII)","IKK16 (IKK Inhibitor VII)","IKK-16 (free base)","IKK16 (free base)","873225-46-8 (free base)","873225468 
(free base)",CHEMBL200027,C28H29N5OS,"IKK Inhibitor",K00596a,"IKK-16(free base)","IKK16(free base)",MLS006011189,"IKK-16;IKK Inhibitor VII","IKK16;IKK Inhibitor VII",SCHEMBL152,T6176,"EMD 401486",4014
86}

> <pdid>
PD010532

> <targets>
{"IkB Kinase","IKK Inhibitor VII"}

> <classes>
{}

> <pubchem_cids>
{9549298}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 N   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
    0.0000   -4.5008    0.0000 N   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2978    3.7529    0.0000 C   0  0
    2.5981    3.0050    0.0000 O   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 C   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -2.6004    2.9990    0.0000 O   0  0
   -3.9002    3.7493    0.0000 C   0  0
   -5.2004    2.9995    0.0000 C   0  0
   -6.6213    3.0430    0.0000 C   0  0
   -5.8692    1.7451    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  7  1  0
  6 13  2  0
 13  2  1  0
 13 14  1  0
 14 15  3  0
  4 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 16  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28194

> <plate>
Kinase v5-1

> <well>
F17

> <supplier_cmpd_name>
401487

> <ctcr_id>
5995

> <supplier_cmpd_id>
EMD 401487

> <smiles>
Nc1nc(cc(C2CCNCC2)c1C#N)c3c(O)cccc3OCC4CC4

> <pd_targets>
{CHUK,IKBKB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase IKK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","IKK family"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 4 (TLR4) Cascade","MyD88-independent TLR4 cascade","TRIF(TICAM1)-mediated TLR4 signaling","IKK complex recruit
ment mediated by RIP1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ACHP,406208-42-2,406208422,CHEMBL368427,SCHEMBL1726425,SCHEMBL17378616,CHEBI:91445,HMS3229F17,ZINC6718453,BDBM50149825,AKOS024458216,ZINC147049887,NCGC00347280-01,NCGC0034728001,NCGC00347280-04,NCGC0
034728004,B5638,BRD-K79018442-001-03-3,BRDK79018442001033,BRD-K79018442-001-04-1,BRDK79018442001041,Q27163292,"EMD 401487",401487}

> <pdid>
PD069810

> <targets>
{"IKK-2 Inhibitor VIII"}

> <classes>
{}

> <pubchem_cids>
{135465539}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -3.8813    1.4408    0.0000 C   0  0
   -5.0460    2.3579    0.0000 S   0  0
   -6.2823    1.5084    0.0000 C   0  0
   -7.6946    2.0087    0.0000 C   0  0
   -9.1085    2.5096    0.0000 N   0  0
   -5.8565    0.0701    0.0000 C   0  0
   -6.7662   -1.1203    0.0000 O   0  0
   -6.1900   -2.5061    0.0000 C   0  0
   -7.1014   -3.6986    0.0000 C   0  0
   -8.5886   -3.5028    0.0000 C   0  0
   -9.5018   -4.6927    0.0000 C   0  0
   -8.9279   -6.0786    0.0000 C   0  0
   -7.4407   -6.2745    0.0000 C   0  0
   -6.5275   -5.0845    0.0000 C   0  0
   -5.0395   -5.2806    0.0000 S   0  0
   -4.1266   -4.0904    0.0000 C   0  0
   -4.4648   -6.6661    0.0000 O   0  0
   -3.5523   -5.4758    0.0000 O   0  0
   -4.3570    0.0307    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  3  0
 11 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 22 23  1  0
 23 24  1  0
 23 25  2  0
 23 26  2  0
 14 27  1  0
 27  9  2  0
  8 28  1  0
 28  5  2  0
 28 29  1  0
 29 30  2  0
 30  3  1  0
 30 31  1  0
 31 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28195

> <plate>
Kinase v5-1

> <well>
F19

> <supplier_cmpd_name>
401488

> <ctcr_id>
1660

> <supplier_cmpd_id>
EMD 401488

> <smiles>
COc1cc2ncn(c3sc(C#N)c(OCc4ccccc4[S](C)(=O)=O)c3)c2cc1OC

> <pd_targets>
{PLK1,IKBKE,TBK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase PLK family","Other protein kinase IKK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Polo-like kinase (PLK) family","IKK family"}

> <pathway_reactome>
{"Cell Cycle","Immune System",Mitotic,"Innate Immune System","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","G2/M Transition","Toll Like Receptor 4 (TLR4) Cascade","Centrosome maturation","MyD
88-independent TLR4 cascade","Loss of proteins required for interphase microtubule organization from the centrosome","TRIF(TICAM1)-mediated TLR4 signaling","Loss of Nlp from mitotic centrosomes","Acti
vation of IRF3/IRF7 mediated by TBK1/IKK epsilon"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"IKK-3 Inhibitor","IKK3 Inhibitor",862812-98-4,862812984,GSK319347A,CAY10576,GSK-319347A,"IKK-3 Inhibitor IX","IKK3 Inhibitor IX",MLS006010828,CHEMBL373751,SCHEMBL3413628,BDBM27452,CHEBI:91459,DTXSID
30469666,HMS3229F19,HMS3303L12,HMS3305M09,BCP24906,"GSK 319347A",1798AH,NSC756172,ZINC19795634,A,10011249,"EMD 401488",401488}

> <pdid>
PD003436

> <targets>
{"IKK-3 Inhibitor IX"}

> <classes>
{}

> <pubchem_cids>
{11626927}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    2.6016    2.9971    0.0000 O   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 C   0  0
    0.0079    7.5003    0.0000 N   0  0
    0.0079    6.0003    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 C   0  0
   -5.7073   -1.5264    0.0000 N   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
  4 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 21 22  1  0
 22 14  1  0
 22 23  2  0
 23  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28196

> <plate>
Kinase v5-1

> <well>
F21

> <supplier_cmpd_name>
401489

> <ctcr_id>
6184

> <supplier_cmpd_id>
EMD 401489

> <smiles>
Clc1cc(NC(=O)c2cccnc2)c3[nH]c4cnccc4c3c1

> <pd_targets>
{IKBKB,PIM1,PIM3,KMT2A,MEN1,ALD,IKBKG,CHUK}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,"Protein Kinase",Bromodomain,"Protein kinase regulatory subunit","Other protein kinase group","CAMK protein kinase group","Other protein kinase IKK family"
,"CAMK protein kinase PIM family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","PIM family","IKK family"}

> <pathway_reactome>
{"Immune System",Disease,"Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Toll-like Receptor Cascades","FLT3 signaling in disease","Toll Like 
Receptor 4 (TLR4) Cascade","Signaling by FLT3 ITD and TKD mutants","MyD88-independent TLR4 cascade","STAT5 activation downstream of FLT3 ITD mutants","TRIF(TICAM1)-mediated TLR4 signaling","IKK comple
x recruitment mediated by RIP1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{PS-1145,PS1145,431898-65-6,431898656,"PS 1145","N-(6-chloro-9h-pyrido(3,4-b)indol-8-yl)-3-pyridinecarboxamide","N(6chloro9hpyrido(3,4b)indol8yl)3pyridinecarboxamide",UNII-12GL090NZZ,UNII12GL090NZZ,"N
-(6-chloro-9H-pyrido(3,4-b)indol-8-yl)nicotinamide","N(6chloro9Hpyrido(3,4b)indol8yl)nicotinamide",CHEMBL79004,12GL090NZZ,"431898-65-6 (free base)","431898656 (free base)",3-Pyridinecarboxamide,3Pyrid
inecarboxamide,N-(6-chloro,N(6chloro,T3094,"EMD 401489",401489}

> <pdid>
PD015727

> <targets>
{"IKK Inhibitor X",Apoptosis,IKK}

> <classes>
{Apoptosis,NF-ºB}

> <pubchem_cids>
{9949093}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 25  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -5.1072    0.0000    0.0000 C   0  0
   -5.8661    1.2801    0.0000 C   0  0
   -7.3245    0.9294    0.0000 N   0  0
   -7.4413   -0.5653    0.0000 C   0  0
   -6.0552   -1.1388    0.0000 C   0  0
   -5.8589   -2.6258    0.0000 C   0  0
   -7.0485   -3.5395    0.0000 C   0  0
   -8.4346   -2.9660    0.0000 C   0  0
   -8.6310   -1.4789    0.0000 C   0  0
   -6.8522   -5.0265    0.0000 I   0  0
   -5.2822    2.6618    0.0000 O   0  0
   -3.1904   -2.6376    0.0000 N   0  0
   -4.6580   -2.9476    0.0000 O   0  0
  1  2  2  3
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  1  1  0
  5  7  1  0
  7  8  2  3
  8  9  1  0
  9  4  1  0
  8 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  1  0
 13 14  2  3
 14 10  1  0
 14 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  2  3
 18 13  1  0
 16 19  1  0
 11 20  1  0
  7 21  1  0
 21 22  2  0
M  END
> <name>
UTKinase_V5

> <id>
28197

> <plate>
Kinase v5-1

> <well>
H03

> <supplier_cmpd_name>
402086

> <ctcr_id>
7695

> <supplier_cmpd_id>
EMD 402086

> <smiles>
C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=C(C=C4)I)O)N=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{IODOINDIRUBIN3'MONOXIM,5-iodo-Indirubin-3'-monoxime,5iodoIndirubin3'monoxime,CHEMBL337300,"Indirubin-3&prime;-monoxime, 5-Iodo-","Indirubin3&prime;monoxime, 5Iodo",K00192,CHEMBL411645,SCHEMBL3854117,
SCHEMBL16985020,3-(3-(hydroxyamino)-1H-indol-2-yl)-5-iodoindol-2-one,3(3(hydroxyamino)1Hindol2yl)5iodoindol2one,HMS3229H03,BDBM50005298,HSCI1_000149,HSCI1000149,HSCI1-000149,"HSCI1 000149",NSC7,"EMD 4
02086",402086}

> <pdid>
PD158678

> <targets>
{}

> <classes>
{}

> <pubchem_cids>
{403176}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
   10.3971   -2.9985    0.0000 O   0  5
    9.0967   -3.7463    0.0000 N   0  3
    9.0946   -5.2463    0.0000 O   0  0
    7.7985   -2.9932    0.0000 C   0  0
    7.7985   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -2.6061    6.0003    0.0000 C   0  0
   -2.6061    7.5003    0.0000 C   0  0
   -1.3071    8.2503    0.0000 C   0  0
   -0.0080    7.5003    0.0000 C   0  0
   -0.0080    6.0003    0.0000 C   0  0
    1.2917    8.2508    0.0000 C   0  0
    1.2926    9.7508    0.0000 F   0  0
    2.5905    7.5004    0.0000 F   0  0
    2.5911    9.0002    0.0000 F   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    6.4995   -3.7432    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 19 21  1  0
 21 22  1  0
 21 23  1  0
 21 24  1  0
 12 25  2  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 10  1  0
 30 26  2  0
  7 31  1  0
 31 32  2  0
 32  4  1  0
M  CHG  2   1  -1   2   1
M  END
> <name>
UTKinase_V5

> <id>
28198

> <plate>
Kinase v5-1

> <well>
H05

> <supplier_cmpd_name>
406170

> <ctcr_id>
3765

> <supplier_cmpd_id>
EMD 406170

> <smiles>
[O-][N+](=O)c1ccc(CNc2nc(NCc3cccc(c3)C(F)(F)F)nc4[nH]cnc24)cc1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"IP3K Inhibitor",519178-28-0,519178280,TNP,CHEMBL467591,"Purine, 5","IP6K1 inhibitor TNP","Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor","Inositol1,4,5trisphosphate 3Kinase Inhibitor","N2-(m-Trifl
uorobenzyl), N6-(p-nitrobenzyl)purine","N2(mTrifluorobenzyl), N6(pnitrobenzyl)purine",SCHEMBL14234675,SCHEMBL14235423,BDBM82310,DTXSID60587903,HMS3229H05,"EMD 406170",406170}

> <pdid>

> <targets>
{IP3K Inhibitor,Others}

> <classes>
{Others}

> <pubchem_cids>
{16760513}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  1  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6924   -4.0811    0.0000 I   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.8813   -1.4408    0.0000 C   0  0  2  0  0  0
   -4.8896   -2.5354    0.0000 O   0  0
   -6.2433   -1.8893    0.0000 C   0  0  2  0  0  0
   -7.5587   -2.6066    0.0000 C   0  0
   -7.5961   -4.1061    0.0000 O   0  0
   -6.0471   -0.4022    0.0000 C   0  0  2  0  0  0
   -7.1349    0.6307    0.0000 O   0  0
   -4.5721   -0.1292    0.0000 C   0  0
   -3.9177    1.2205    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
  9 11  1  0
 11  2  1  0
 11  6  2  0
 12  7  1  6
 12 13  1  0
 13 14  1  0
 14 15  1  6
 15 16  1  0
 14 17  1  0
 17 18  1  6
 17 19  1  0
 19 12  1  0
 19 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28199

> <plate>
Kinase v5-1

> <well>
H07

> <supplier_cmpd_name>
407900

> <ctcr_id>
7696

> <supplier_cmpd_id>
EMD 407900

> <smiles>
Nc1ncnc2n(cc(I)c12)[C@@H]3O[C@H](CO)[C@H](O)C3O

> <pd_targets>
{ADK,MAPK1,ADOK,DOT1L}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Transferase,Kinase,Writer,"Protein Kinase","Protein methyltransferase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,"Adenosine turnover","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","CMGC: Containing CDK",MAPK,GSK3,"CLK families","2.1.1.43 Histone methyltransferases (HMTs)","Mitogen-activated prote
in kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Immune System","Chromatin organization","Metabolism of nucleotides","Innate Immune System","Chromatin modifying enzymes","Nucleotide salvage","Toll-like Receptor Cascades","PKMTs methylat
e histone lysines","Purine salvage","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","E
RK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"NSC 113939",5-ITu,5ITu,7-Deaza-7-iodoadenosine,7Deaza7iodoadenosine,SCHEMBL12618424,HMS3229H07,HMS3403M09,HMS3886B10,"4-Amino-5-iodo-7-(beta-D-ribofuranosyl)pyrrolo(2,3-d)pyrimidine","4Amino5iodo7(b
etaDribofuranosyl)pyrrolo(2,3d)pyrimidine",s8314,CCG-268549,CCG268549,W-202018,W202018,S8314,"EMD 407900",5-Iodotubercidin,407900}

> <pdid>
PD005972

> <targets>
{5-Iodotubercidin,"adenosine receptor"}

> <classes>
{"GPCR & G Protein"}

> <pubchem_cids>
{16760523}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 47  0  0  1  0            999 V2000
   -7.9103  -10.0831    0.0000 C   0  0
   -6.4176   -9.9359    0.0000 C   0  0
   -5.7975   -8.5692    0.0000 C   0  0
   -4.3039   -8.4219    0.0000 C   0  0
   -3.6837   -7.0552    0.0000 C   0  0
   -2.1902   -6.9079    0.0000 C   0  0
   -1.5700   -5.5412    0.0000 O   0  0
   -0.0765   -5.3940    0.0000 C   0  0
    0.7970   -6.6134    0.0000 O   0  0
    0.5600   -4.0500    0.0000 C   0  0  2  0  0  0
    2.0502   -3.8790    0.0000 O   0  0
   -0.9400   -4.0500    0.0000 C   0  0
   -1.4100   -2.5800    0.0000 C   0  0  2  0  0  0
   -0.1700   -1.6900    0.0000 O   0  0
    1.0600   -2.5800    0.0000 C   0  0  2  0  0  0
    2.4742   -3.0802    0.0000 C   0  0
    1.6000   -1.1100    0.0000 N   0  0
    3.0200   -0.4800    0.0000 C   0  0
    4.4200   -1.1200    0.0000 C   0  0
    5.6800   -0.2100    0.0000 C   0  0
    5.5200    1.3100    0.0000 C   0  0
    4.1100    1.9400    0.0000 C   0  0
    2.8600    1.0300    0.0000 C   0  0
    1.3500    1.3600    0.0000 C   0  0
    0.5900    2.7000    0.0000 C   0  0
    1.0600    4.1700    0.0000 C   0  0
   -0.1700    5.0800    0.0000 N   0  0
   -1.4200    4.1700    0.0000 C   0  0
   -2.8476    4.6304    0.0000 O   0  0
   -0.9400    2.7100    0.0000 C   0  0
   -1.7200    1.3700    0.0000 C   0  0
   -3.2300    1.0500    0.0000 C   0  0
   -4.4800    1.9600    0.0000 C   0  0
   -5.8800    1.3300    0.0000 C   0  0
   -6.0500   -0.1900    0.0000 C   0  0
   -4.8000   -1.1000    0.0000 C   0  0
   -3.3900   -0.4700    0.0000 C   0  0
   -1.9800   -1.1000    0.0000 N   0  0
   -0.9500    0.0400    0.0000 C   0  0
    0.5600    0.0300    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  1
 10 12  1  0
 13 12  1  1
 13 14  1  0
 14 15  1  0
 15 10  1  0
 15 16  1  6
 15 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 28 30  1  0
 30 25  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 32  1  0
 37 38  1  0
 38 13  1  0
 38 39  1  0
 39 31  1  0
 39 40  2  0
 40 17  1  0
 40 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28200

> <plate>
Kinase v5-1

> <well>
H09

> <supplier_cmpd_name>
420320

> <ctcr_id>
7697

> <supplier_cmpd_id>
EMD 420320

> <smiles>
CCCCCCOC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

> <pd_targets>
{PDK1,CHRM4,CHRM1,LMTK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PDHK subfamily","Membrane receptor","Family A G protein-coupled receptor","Small molecule receptor (family A GP
CR)","Monoamine receptor","Acetylcholine receptor",Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"PDHK family",Receptors,"G protein-coupled receptors","Acetylcholine receptors (muscarinic)","Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Re
ceptor tyrosine kinases (RTKs)","Type XVIII RTKs: LMR family"}

> <pathway_reactome>
{Metabolism,"The citric acid (TCA) cycle and respiratory electron transport","Pyruvate metabolism and Citric Acid (TCA) cycle","Pyruvate metabolism","Regulation of pyruvate dehydrogenase (PDH) complex
","Signal Transduction","Signaling by GPCR","GPCR ligand binding","Class A/1 (Rhodopsin-like receptors)","Amine ligand-binding receptors","Muscarinic acetylcholine receptors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{KT5720,"KT 5720",108068-98-0,108068980,UNII-58HV29I28S,UNII58HV29I28S,KT-5720,58HV29I28S,"InSolution&trade; KT5720","antibiotic KT 5720",SCHEMBL16112156,BDBM14030,CHEBI:85085,DTXSID40910614,HMS3229H0
9,HY-N6789,HYN6789,ZINC3873012,MFCD00132118,AKOS030213134,"hexyl hydroxy-methyl-ox","hexyl hydroxymethylox","EMD 420320",420320}

> <pdid>
PD020147

> <targets>
{KT5720}

> <classes>
{}

> <pubchem_cids>
{454202}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 37  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 N   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -5.1971    2.9990    0.0000 C   0  0
   -6.4977    3.7464    0.0000 C   0  0
   -6.5007    5.2464    0.0000 C   0  0
   -5.2032    5.9990    0.0000 C   0  0
   -3.9027    5.2517    0.0000 C   0  0
   -2.6060    6.0074    0.0000 C   0  0
   -2.6113    7.5082    0.0000 N   0  0
   -3.9131    8.2533    0.0000 C   0  0
   -1.3146    8.2640    0.0000 C   0  0
   -1.3199    9.7648    0.0000 C   0  0
   -0.0232   10.5206    0.0000 C   0  0
   -0.0285   12.0214    0.0000 C   0  0
    1.2664   12.7787    0.0000 C   0  0
    1.2581   14.2787    0.0000 C   0  0
   -0.0451   15.0215    0.0000 C   0  0
   -0.0534   16.5215    0.0000 Cl  0  0
   -1.3400   14.2643    0.0000 C   0  0
   -1.3317   12.7643    0.0000 C   0  0
    5.0980    6.0096    0.0000 O   0  0
    6.3972    6.7591    0.0000 P   0  0
    7.6965    6.0096    0.0000 O   0  0
    6.3972    8.2591    0.0000 O   0  0
    6.3972    5.2591    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  6  9  1  0
  9 10  2  0
  9 11  2  0
  9 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 28 30  1  0
 30 31  2  0
 31 25  1  0
 32 33  1  0
 33 34  2  0
 33 35  1  0
 33 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28201

> <plate>
Kinase v5-1

> <well>
H11

> <supplier_cmpd_name>
422709

> <ctcr_id>
1693

> <supplier_cmpd_id>
EMD 422709

> <smiles>
COc1ccc(cc1)S(=O)(=O)Nc2ccccc2CN(C)CC=Cc3ccc(Cl)cc3.OP(=O)(O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SCHEMBL3966925,AKOS032960424,T4530,"EMD 422709","KN-92 phosphate",422709}

> <pdid>
PD070113

> <targets>
{KN-92}

> <classes>
{}

> <pubchem_cids>
{24906277}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 N   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 C   0  0
   -1.2942   -8.2509    0.0000 O   0  0
    0.0036   -7.4988    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  1  0
 18  8  1  0
 18 12  2  0
 16 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28202

> <plate>
Kinase v5-1

> <well>
H13

> <supplier_cmpd_name>
440206

> <ctcr_id>
3560

> <supplier_cmpd_id>
EMD 440206

> <smiles>
Nc1ccc(cc1)c2cccc3C(=O)C=C(Oc23)N4CCOCC4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{942289-87-4,942289874,PI-828,PI828,"PI 828",8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one,8(4Aminophenyl)2(4morpholinyl)4H1benzopyran4one,8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-
4-one,8(4aminophenyl)2(4morpholinyl)1benzopyran4one,"LY 294002, 4gamma-NH2","LY 294002, 4gammaNH2",8-(4-aminophenyl)-2-morpholino-4H-chromen-4-one,8(4aminophenyl)2morpholino4Hchromen4one,SCHEMBL137000
43,CHEBI:93710,DTXSI,2814,"EMD 440206",440206}

> <pdid>
PD021756

> <targets>
{"PI 3-Kinase",4'-NH2,"LY 294002",PI3K}

> <classes>
{}

> <pubchem_cids>
{25181195}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    2.6015   -1.5060    0.0000 C   0  0
    2.5973   -3.0060    0.0000 C   0  0
    3.8942   -3.7597    0.0000 C   0  0
    3.8899   -5.2597    0.0000 C   0  0
    5.1868   -6.0134    0.0000 I   0  0
    2.5887   -6.0060    0.0000 C   0  0
    1.2918   -5.2523    0.0000 C   0  0
    1.2961   -3.7523    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0128   -6.0039    0.0000 F   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -2.6160   -7.4949    0.0000 F   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2089   -5.9859    0.0000 F   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -2.5984   -1.4941    0.0000 C   0  0
   -1.2981   -0.7463    0.0000 O   0  0
   -3.8966   -0.7411    0.0000 N   0  0
   -3.8946    0.7597    0.0000 O   0  0
   -5.1928    1.5127    0.0000 C   0  0
   -5.1908    3.0135    0.0000 C   0  0
   -5.9366    4.2238    0.0000 C   0  0
   -4.4366    4.2186    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18 10  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28203

> <plate>
Kinase v5-1

> <well>
H15

> <supplier_cmpd_name>
444965

> <ctcr_id>
3170

> <supplier_cmpd_id>
EMD 444965

> <smiles>
Cc1cc(I)ccc1Nc2c(F)c(F)c(F)cc2C(=O)NOCC3CC3

> <pd_targets>
{RORC,KMT2A,MEN1}

> <pathway_gtopdb>
{"Transcription factor","Epigenetic regulator","Nuclear receptor",Reader,"Nuclear hormone receptor subfamily 1",Bromodomain,"Nuclear hormone receptor subfamily 1 group F","Nuclear hormone receptor sub
family 1 group F member 3"}

> <pathway_chembl>
{Receptors,"Nuclear hormone receptors","1F. Retinoic acid-related orphans"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional regulation by RUNX3","RUNX3 Regulates Immune Response and Cell Migration"}

> <broad_targets>
{MAP2K1,MAP2K2}

> <broad_moa>
{"MAP kinase inhibitor","MEK inhibitor"}

> <synonyms>
{HMS3413J17,HMS3677J17,ZINC3964489,"PD 198306",212631-61-3,212631613,PD-198306,PD198306,UNII-WQ5121ZGT3,UNIIWQ5121ZGT3,WQ5121ZGT3,SCHEMBL1801637,CHEMBL1474985,CHEBI:93541,DTXSID70433306,HMS3229H15,HMS
3269F09,AKOS024457191,NCGC00167793-01,NCGC0016779301,NCGC00167793-02,NCGC0016779302,B7124,J-013958,J013958,BRD-K88677950-,BRDK88677950,2605,"EMD 444965",444965}

> <pdid>
PD015686

> <targets>
{MEK1/2,MEK,"MEK1/2 Inhibitor II"}

> <classes>
{}

> <pubchem_cids>
{9956637}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    7.8806   -4.3196    0.0000 O   0  0
    0.8806   -8.8283    0.0000 O   0  0
    2.3806   -8.8331    0.0000 C   0  0
    3.1264  -10.1345    0.0000 N   0  0
    4.6264  -10.1392    0.0000 C   0  0
    5.3806   -8.8426    0.0000 C   0  0
    4.6347   -7.5412    0.0000 C   0  0
    5.1027   -6.1169    0.0000 N   0  0
    3.8919   -5.2532    0.0000 C   0  0
    2.6757   -6.1092    0.0000 C   0  0
    3.1347   -7.5364    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  3  1  0
 11  7  2  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 16 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 21  1  0
 26 27  2  0
 27 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28204

> <plate>
Kinase v5-1

> <well>
H17

> <supplier_cmpd_name>
475864

> <ctcr_id>
6841

> <supplier_cmpd_id>
EMD 475864

> <smiles>
O.O=C1NCCc2[nH]c(cc12)c3ccnc(c3)c4cnc5ccccc5c4

> <pd_targets>
{MAPK12,PRKAA1,PIM1,SRPK1,MAPKAPK2,PLK4,CSNK1G1,IRAK1,MAPKAPK3,MAPKAPK5,MAPK9,DYRK1A,CSNK1D,DYRK4,MKNK1,MAPK1,CLK2,PRKD2,MAP4K4,DAPK3,CSNK1A1,CAMK2B,PIM2,CAMK2G,BRSK1,MKNK2,DYRK3,CDK1,RPS6KB1,STK17A,C
SNK2A1,CHEK2,PIM3,MINK1,MAPK8,CLK4,AURKB,PRKD3,CSNK1G2,MAP4K2,CAMK2D}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CAMK protein kinase group","Other protein kinase group","CK1 protein kinase group","TKL protein kinase group","STE protein kinase group","A
GC protein kinase group","CMGC protein kinase MAPK family","CAMK protein kinase CAMK1 family","CAMK protein kinase PIM family","CMGC protein kinase SRPK family","CAMK protein kinase MAPKAPK family","O
ther protein kinase PLK family","CK1 protein kinase CK1 family","TKL protein kinase IRAK family","CMGC protein kinase DYRK family","CMGC protein kinase CLK family","CAMK protein kinase PKD family","ST
E protein kinase STE20 family","CAMK protein kinase DAPK family","CAMK protein kinase CAMK2 family","CMGC protein kinase CDK family","AGC protein kinase RSK family","Other protein kinase CK2 family","
CAMK protein kinase RAD53 family","Other protein kinase AUR family","CMGC protein kinase p38 subfamily","CAMK protein kinase AMPK subfamily","CAMK protein kinase MAPKAPK subfamily","CMGC protein kinas
e JNK subfamily","CMGC protein kinase Dyrk1 subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase ERK1","STE protein kinase MSN subfamily","CAMK protein kinase BRSK subfamily","CMGC prot
ein kinase Dyrk2 subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase p70 subfamily","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","CK1: Casein kin
ase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","Mitogen-activated protein kinases (MAP kinases)","CAMK-like (CAMKL) family","PIM f
amily","SRPK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Other protein kinases","Casein kinase 1 (CK1) family","TKL: Tyrosine kinase-like","Dual-specificity tyrosine-(Y)-phosphorylation 
regulated kinase (DYRK) family","CLK family","Protein kinase D (PKD) family","STE20 family","Death-associated kinase (DAPK) family","CAMK2 family","Cyclin-dependent kinase (CDK) family","RSK family","
p38 subfamily","AMPK subfamily","MAPKAPK subfamily","Polo-like kinase (PLK) family","Interleukin-1 receptor-associated kinase (IRAK) family","JNK subfamily","Dyrk1 subfamily","MKN subfamily","ERK subf
amily","MSN subfamily","BRSK subfamily","Dyrk2 subfamily","CDK1 subfamily","p70 subfamily","Casein kinase 2 (CK2) family","CHK1 subfamily","Aurora kinase (Aur) family","KHS subfamily"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Disease,"Immune System","Cell Cycle",Metabolism,"Cellular responses to external stimuli","Programmed Cell Death","Neuronal System","Signaling b
y Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System",Mitotic,"Metabolism of lipids",
"Cellular responses to stress",Apoptosis,"Transmission across Chemical Synapses","MTOR signalling","Signaling by NTRKs","Generic Transcription Pathway","FLT3 signaling in disease","Toll-like Receptor 
Cascades","Mitotic G2-G2/M phases","Mitotic G1 phase and G1/S transition","Signaling by FGFR","Sphingolipid metabolism","Cellular Senescence","Caspase activation via extrinsic apoptotic signalling pat
hway","Signaling by WNT in cancer","Neurotransmitter receptors and postsynaptic signal transmission","Regulation of mitotic cell cycle","mTORC1-mediated signalling","M Phase","Signaling by NTRK1 (TRKA
)","Transcriptional Regulation by TP53","Signaling by FLT3 ITD and TKD mutants","Toll Like Receptor 5 (TLR5) Cascade","G2/M Transition","G0 and Early G1","Signaling by FGFR4","Sphingolipid de novo bio
synthesis","Oxidative Stress Induced Senescence","Caspase activation via Dependence Receptors in the absence of ligand","Signaling by AMER1 mutants","Activation of NMDA receptors and postsynaptic even
ts","APC/C-mediated degradation of cell cycle proteins","Mitotic Metaphase and Anaphase","Signalling to ERKs","Regulation of TP53 Activity","STAT5 activation downstream of FLT3 ITD mutants","MyD88 cas
cade initiated on plasma membrane","Centrosome maturation","Negative regulation of FGFR4 signaling","Truncations of AMER1 destabilize the destruction complex","Post NMDA receptor activation events","A
ctivation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Mitotic Anaphase","Signalling to RAS","Regulation of TP53 Activity through Phosphorylation","MAP kinase activation","Loss 
of proteins required for interphase microtubule organization from the centrosome","Spry regulation of FGF signaling","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling",
"APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Expression and Degradation","Separation of Sister Chromatids","p38MAPK events","MAPK targets/ Nuclear events mediated by MAP 
kinases","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK activation","Ras activation upon Ca2+ influx through NMDA receptor","APC:Cdc20 mediated degradation of cell cycle prot
eins prior to satisfation of the cell cycle checkpoint","Regulation of TP53 Degradation","CREB phosphorylation","Activation of the AP-1 family of transcription factors","ERK/MAPK targets","Cdc20:Phosp
ho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"MK-2 Inhibitor III","MK2 Inhibitor III",1186648-22-5,1186648225,HMS3229H17,HY-112457,HY112457,CS-0046083,CS0046083,J-003867,J003867,"EMD 475864",475864}

> <pdid>
PD004473

> <targets>
{"MK-2 Inhibitor III"}

> <classes>
{}

> <pubchem_cids>
{25163932}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 23  0  0  0  0            999 V2000
    7.5987   -1.2614    0.0000 H   0  3
    5.0987   -1.2614    0.0000 Cl  0  5
    2.5981   -1.5000    0.0000 I   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8978   -0.7496    0.0000 S   0  0
   -3.8974    0.7504    0.0000 O   0  0
   -2.5987    0.0002    0.0000 O   0  0
   -5.1981   -1.4992    0.0000 N   0  0
   -5.1012   -3.0033    0.0000 C   0  0
   -6.2014   -4.0229    0.0000 C   0  0
   -7.6846   -3.7984    0.0000 C   0  0
   -8.4337   -2.4989    0.0000 N   0  0
   -7.8848   -1.1029    0.0000 C   0  0
   -6.4512   -0.6617    0.0000 C   0  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14 15  2  0
 14 16  2  0
 14 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 17  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28205

> <plate>
Kinase v5-1

> <well>
H19

> <supplier_cmpd_name>
475880

> <ctcr_id>
3040

> <supplier_cmpd_id>
EMD 475880

> <smiles>
[H+].[Cl-].Ic1cccc2c1cccc2[S](=O)(=O)N3CCCNCC3

> <pd_targets>
{NPSR1,LMNA,GMNN,CYP3A4,CYP2D6,ROCK1,TP53,CYP2C19,CYP1A2,TSHR,LEF,MYLK,NFKB1,RORC,MTOR,CHRM1,NFO,MAPT,MAPK1,PMP22,KMT2A,MEN1,TRPC6}

> <pathway_gtopdb>
{"Membrane receptor","Other nuclear protein","Unclassified protein",Enzyme,"Transcription factor","Other cytosolic protein","Family A G protein-coupled receptor","Cytochrome P450",Kinase,Protease,"Nuc
lear receptor","Peptide receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Protein Kinase","Cytochrome P450 family 1","Metallo protease","Nuclear hormone receptor subfami
ly 1","Short peptide receptor (family A GPCR)","Cytochrome P450 family 3A","Cytochrome P450 family 2D","AGC protein kinase group","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Glycohormone 
receptor","Metallo protease MAE clan","CAMK protein kinase group","Nuclear hormone receptor subfamily 1 group F","Atypical protein kinase group","Neuropeptide receptor","Cytochrome P450 3A4","Cytochro
me P450 2D6","AGC protein kinase DMPK family","Cytochrome P450 2C19","Cytochrome P450 1A1","Metallo protease M34 family","CAMK protein kinase MLCK family","Nuclear hormone receptor subfamily 1 group F
 member 3","Atypical protein kinase PIKK family","AGC protein kinase ROCK subfamily","Atypical protein kinase FRAP subfamily","Epigenetic regulator","Ion channel",Hydrolase,Reader,"Voltage-gated ion c
hannel","Small molecule receptor (family A GPCR)",Bromodomain,"Transient receptor potential channel","Monoamine receptor","CMGC protein kinase group","Acetylcholine receptor","CMGC protein kinase MAPK
 family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"G protein-coupled receptors","Cytochrome P450","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Neuropeptide S receptor","CYP3 family","CYP2 family: drug metabolising subset","A
GC: Containing PKA",PKG,"PKC families","CYP1 family","Glycoprotein hormone receptors","CAMK: Calcium/calmodulin-dependent protein kinases","1F. Retinoic acid-related orphans",Atypical,"DMPK family","M
yosin Light Chain Kinase (MLCK) family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Rho kinase","FRAP subfamily","Ion channels","Voltage-gated ion channels","Acetylcholine recepto
rs (muscarinic)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Transient Receptor Potential channels","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{Disease,"Cell Cycle",Metabolism,"Developmental Biology","Signal Transduction","Immune System","Gene expression (Transcription)","Infectious disease",Mitotic,"Metabolism of lipids","Biological oxidati
ons","Nervous system development","Cell Cycle Checkpoints","Signaling by Rho GTPases","Cytokine Signaling in Immune system","RNA Polymerase II Transcription","Leishmania infection","M Phase","Mitotic 
G1 phase and G1/S transition","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","Axon guidance","G1/S DNA Damage Checkpoints","Uptake and actions o
f bacterial toxins","RHO GTPase Effectors","Signaling by Interleukins","Generic Transcription Pathway","Leishmania parasite growth and survival","Mitotic Metaphase and Anaphase","G1/S Transition","Bio
synthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Semaphorin interactions","p53-Dependent G1/S DNA damage checkpoint","Uptake and function of anthrax toxins","RHO GTPases 
activate PAKs","Interleukin-1 family signaling","Transcriptional regulation by RUNX3","Transcriptional Regulation by TP53","Anti-inflammatory response favouring Leishmania parasite infection","Mitotic
 Anaphase","Activation of the pre-replicative complex","Biosynthesis of maresins",Xenobiotics,"Sema4D in semaphorin signaling","p53-Dependent G1 DNA Damage Response","Interleukin-1 signaling","RUNX3 R
egulates Immune Response and Cell Migration","Regulation of TP53 Activity","ADORA2B mediated anti-inflammatory cytokines production","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SP
Ms","CYP2E1 reactions","Sema4D induced cell migration and growth-cone collapse","Stabilization of p53","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent MAPK1
/3 activation","Regulation of TP53 Expression and Degradation","Initiation of Nuclear Envelope (NE) Reformation","Autodegradation of the E3 ubiquitin ligase COP1","Regulation of TP53 Degradation","Neu
ronal System","Signaling by GPCR","Transmission across Chemical Synapses","Innate Immune System","GPCR ligand binding","Neurotransmitter receptors and postsynaptic signal transmission","Toll-like Rece
ptor Cascades","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Class A/1 (Rhodopsin-like receptors)","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 5 (TLR
5) Cascade","Netrin-1 signaling","Amine ligand-binding receptors","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","Role of second messengers in netrin-1 signaling",
"Muscarinic acetylcholine receptors","Activation of AMPK downstream of NMDARs","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{TRPC6}

> <broad_moa>
{"myosin light chain kinase inhibitor"}

> <synonyms>
{SCHEMBL1981350,110448-33-4,110448334,"ML-7 HYDROCHLORIDE","ML7 HYDROCHLORIDE","1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride","1((5Iodonaphthalen1yl)sulfonyl)1,4diazepane hydrochlor
ide","ML-7 HCl","ML7 HCl","ML 7 hydrochloride","ML 7","ML-7 (hydrochloride)","ML7 (hydrochloride)",1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,1(5Iodonaphthalene1sulfonyl)1Hhexahydro1,"4-diazepine
 hydrochlori","4diazepine hydrochlori",T3050,EI-197,"EMD 475880","ML-7 hydrochloride",475880,ML-7?HCl}

> <pdid>
PD015772

> <targets>
{"Serine/threonin kinase",MLCK,ML-7,Hydrochloride}

> <classes>
{}

> <pubchem_cids>
{67236210,9803932}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 20  0  0  0  0            999 V2000
   -0.6810   -9.3430    0.0000 C   0  0
   -0.2222   -7.9149    0.0000 N   0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6079   -6.7003    0.0000 O   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
    1.2028   -7.4466    0.0000 C   0  0
    2.4192   -8.3243    0.0000 S   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  7  1  0
 15 10  1  0
  5 16  1  0
 16 17  1  0
 17  2  1  0
 17 18  2  0
M  END
> <name>
UTKinase_V5

> <id>
28206

> <plate>
Kinase v5-1

> <well>
H21

> <supplier_cmpd_name>
480065

> <ctcr_id>
2539

> <supplier_cmpd_id>
EMD 480065

> <smiles>
CN1C(=O)C(Cc2c[nH]c3ccccc23)NC1=S

> <pd_targets>
{SMN1,TP53,GLA,FFP,CYP3A4,MAPT,RIPK1,THRB,RORC,IDO1,HSD17B10}

> <pathway_gtopdb>
{"Epigenetic regulator","Transcription factor",Enzyme,"Other cytosolic protein",Reader,Hydrolase,Transferase,"Cytochrome P450",Kinase,"Nuclear receptor",Oxidoreductase,"Methyl-lysine/arginine binding 
protein","Cytochrome P450 family 3","Protein Kinase","Nuclear hormone receptor subfamily 1","Tudor domain","Cytochrome P450 family 3A","TKL protein kinase group","Nuclear hormone receptor subfamily 1 
group A","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 3A4","TKL protein kinase RIPK family","Nuclear hormone receptor subfamily 1 group A member 2","Nuclear hormone receptor subfami
ly 1 group F member 3"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Catalytic receptors","Nuclear hormone receptors","1.13.11.- Dioxygenases","CYP3 family","Receptor kinases","1A. Thyroid hormone receptors","1F. Retinoic acid-rela
ted orphans","TKL: Tyrosine kinase-like","Receptor interacting protein kinase (RIPK) family"}

> <pathway_reactome>
{"Metabolism of RNA","Cell Cycle",Metabolism,"Neuronal System","Immune System","Metabolism of proteins","Gene expression (Transcription)","Metabolism of non-coding RNA","Cell Cycle Checkpoints","Metab
olism of lipids","Transmission across Chemical Synapses","Innate Immune System","Post-translational protein modification","RNA Polymerase II Transcription","Metabolism of amino acids and derivatives",
"snRNP Assembly","G1/S DNA Damage Checkpoints","Sphingolipid metabolism","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotransmitter receptors and postsynaptic signal transmission","
Toll-like Receptor Cascades",SUMOylation,"Generic Transcription Pathway","Tryptophan catabolism","Branched-chain amino acid catabolism","p53-Dependent G1/S DNA damage checkpoint","Glycosphingolipid me
tabolism","Biosynthesis of DHA-derived SPMs","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 4 (TLR4) Cascade","SUMO E3 ligases SUMOylate target proteins","Transcriptional r
egulation by RUNX3","p53-Dependent G1 DNA Damage Response","Biosynthesis of maresins","Post NMDA receptor activation events","MyD88-independent TLR4 cascade","SUMOylation of intracellular receptors","
RUNX3 Regulates Immune Response and Cell Migration","Stabilization of p53","Biosynthesis of maresin-like SPMs","Activation of AMPK downstream of NMDARs","TRIF(TICAM1)-mediated TLR4 signaling","Autodeg
radation of the E3 ubiquitin ligase COP1","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
{RIPK1}

> <broad_moa>
{"RIPK inhibitor"}

> <synonyms>
{Necrostatin-1,Necrostatin1,4311-88-0,4311880,MTH-DL-Tryptophan,MTHDLTryptophan,Nec-1,Nec1,"Necrostatin 1",5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone,5(1Hindol3ylmethyl)3methyl2thioxo
4Imidazolidinone,5-((1H-indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one,5((1Hindol3yl)methyl)3methyl2thioxoimidazolidin4one,MTH-trp,MTHtrp,methyl-thiohydantoin-tryptophan,methylthiohydantointry
ptophan,"Necrostatin-1 inactive","Necrostatin1 inactive",T1847,N9037,"EMD 480065",S8037,necrostatin-1,480065}

> <pdid>
PD003691

> <targets>
{Necrostatin-1,TNF-alpha,Autophagy,Ferroptosis,"Indoleamine 2,3-Dioxygenase (IDO)","RIP kinase"}

> <classes>
{Apoptosis,Autophagy,Metabolic Enzyme/Protease}

> <pubchem_cids>
{2828334}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3070    5.2502    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
    0.0080    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    3.9050    5.2503    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 17 18  1  0
  9 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 22 26  1  0
 26 19  2  0
 26 27  1  0
 27  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28207

> <plate>
Kinase v5-1

> <well>
J03

> <supplier_cmpd_name>
495621

> <ctcr_id>
3605

> <supplier_cmpd_id>
EMD 495621

> <smiles>
CCC(CO)N=C1NC(=NCc2ccccc2O)c3ncn(C(C)C)c3N1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{500735-47-7,500735477,OlomoucineII,IN1181,SCHEMBL3514137,CHEBI:95098,DTXSID60435137,NSC736738,NSC-736738,"Olomoucine II, >=97 (HPLC), powder","Olomoucine II - CAS 500735-47-7","Olomoucine II  CAS 500
735477",Q27166865,"EMD 495621",495621}

> <pdid>

> <targets>
{"Olomoucine II"}

> <classes>
{}

> <pubchem_cids>
{10067756}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 S   0  0
    1.3039   -3.7494    0.0000 S   0  0
    1.3070   -5.2502    0.0000 C   0  0
    0.0080   -6.0003    0.0000 C   0  0
   -1.2911   -5.2504    0.0000 O   0  0
    0.0080   -7.5003    0.0000 C   0  0
    1.3071   -8.2503    0.0000 C   0  0
    2.6061   -7.5003    0.0000 C   0  0
    3.9052   -8.2502    0.0000 C   0  0
    5.2042   -7.5002    0.0000 C   0  0
    5.2041   -6.0002    0.0000 C   0  0
    3.9051   -5.2502    0.0000 C   0  0
    2.6060   -6.0003    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10  5  1  0
 10 11  2  0
 11  2  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 14  1  0
 24 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28208

> <plate>
Kinase v5-1

> <well>
J05

> <supplier_cmpd_name>
506106

> <ctcr_id>
4921

> <supplier_cmpd_id>
EMD 506106

> <smiles>
Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34

> <pd_targets>
{USP2,PAK1,REP}

> <pathway_gtopdb>
{Enzyme,Protease,Kinase,Transferase,"Cysteine protease","Protein Kinase","Cysteine protease CA clan","STE protein kinase group","Cysteine protease C19 family","STE protein kinase STE20 family","STE pr
otein kinase PAKA subfamily"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Peptidases and proteinases","Kinases (EC 2.7.x.x)","Anti-infective targets","CA: Cysteine (C) Peptidases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 
kinases","Viral protein targets","C19: Ubiquitin-specific protease","STE20 family","Coronavirus (CoV) proteins","PAKA subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Developmental Biology",Disease,"RNA Polymerase II Transcription","Nervous system development","Infectious disease","Generic Transcription Pathway","Axon guidance","
SARS-CoV Infections","Transcriptional Regulation by TP53","EPH-Ephrin signaling","SARS-CoV-2 Infection","Regulation of TP53 Activity","EPHB-mediated forward signaling","SARS-CoV-2 Genome Replication a
nd Transcription","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-2 genome","Regulation of TP53 Degradation"}

> <broad_targets>
{PAK1}

> <broad_moa>
{"p21 activated kinase inhibitor"}

> <synonyms>
{IPA-3,IPA3,42521-82-4,42521824,"IPA 3","1,1'-Dithiodi-2-naphthol","1,1'Dithiodi2naphthol","Bis(2-hydroxy-1-naphthyl) disulfide","Bis(2hydroxy1naphthyl) disulfide","1,1'-disulfanediylbis(naphthalen-2-
ol)","1,1'disulfanediylbis(naphthalen2ol)",UNII-3XFG6MQ9G2,UNII3XFG6MQ9G2,3XFG6MQ9G2,"1,1'-Dithiodi-2-naphthtol","1,1'Dithiodi2naphthtol",1-((2-hydroxynaphthalen-1-yl)disulfanyl)naphthalen-2-ol,1((2hy
droxynaphthalen1yl)disulfanyl)naphthalen2ol,C,"EMD 506106",506106}

> <pdid>
PD010626

> <targets>
{"p21-Activated Kinase Inhibitor III",IPA-3,PAK}

> <classes>
{Cell Cycle/DNA Damage,Cytoskeleton}

> <pubchem_cids>
{521106}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 24  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 Cl  0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.1651   -1.2500    0.0000 Cl  0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 S   0  0
    1.2993   -3.7504    0.0000 O   0  0
    1.2989   -2.2506    0.0000 O   0  0
   -1.2993   -3.7521    0.0000 C   0  0
   -1.2983   -5.2521    0.0000 C   0  0
    0.0012   -6.0012    0.0000 O   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5959   -7.5029    0.0000 Cl  0  0
   -3.8964   -5.2537    0.0000 C   0  0
   -3.8973   -3.7537    0.0000 C   0  0
   -5.1969   -3.0045    0.0000 Cl  0  0
   -2.5988   -3.0029    0.0000 C   0  0
   -2.5994   -2.0029    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  8 10  2  0
 10  2  1  0
 10 11  1  0
 11 12  2  0
 11 13  2  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  1  0
 17 19  2  0
 19 20  1  0
 20 21  1  0
 20 22  2  0
 22 14  1  0
 22 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28209

> <plate>
Kinase v5-1

> <well>
J07

> <supplier_cmpd_name>
506153

> <ctcr_id>
6791

> <supplier_cmpd_id>
EMD 506153

> <smiles>
Oc1c(Cl)cc(Cl)c(Cl)c1[S](=O)(=O)c2c(O)c(Cl)cc(Cl)c2Cl

> <pd_targets>
{}

> <pathway_gtopdb>
{Enzyme}

> <pathway_chembl>
{"Other protein targets","Anti-infective targets","Viral protein targets","Coronavirus (CoV) proteins"}

> <pathway_reactome>
{Disease,"Infectious disease","SARS-CoV Infections","SARS-CoV-1 Infection","SARS-CoV-1 Genome Replication and Transcription","Replication of the SARS-CoV-1 genome"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"p38 MAP Kinase Inhibitor IV",1638-41-1,1638411,"2,2'-Sulfonyl-bis-(3,4,6-trichlorophenol)","2,2'Sulfonylbis(3,4,6trichlorophenol)",UNII-71127S05IX,UNII71127S05IX,"2,2'-sulfonylbis(3,4,6-trichlorophe
nol)","2,2'sulfonylbis(3,4,6trichlorophenol)",71127S05IX,"Phenol,2,2'-sulfonylbis(3,4,6-trichloro)-","Phenol,2,2'sulfonylbis(3,4,6trichloro)","p38 MAPK Inhibitor IV",C12H4Cl6O4S,HL-7,HL7,SCHEMBL142,"E
MD 506153",506153}

> <pdid>
PD057805

> <targets>
{"p38 MAP Kinase Inhibitor IV"}

> <classes>
{}

> <pubchem_cids>
{3816490}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 S   0  0
   -1.3032    3.7490    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
    1.2947   -3.7531    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 N   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -5.2111   -5.9837    0.0000 C   0  0
   -6.5072   -5.2269    0.0000 C   0  0
   -7.8115   -5.9679    0.0000 C   0  0
   -9.1053   -5.2089    0.0000 C   0  0
   -9.0949   -3.7089    0.0000 C   0  0
   -7.7907   -2.9679    0.0000 C   0  0
   -6.4969   -3.7269    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  5  8  2  0
  8  9  1  0
  9 10  2  0
 10  3  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 13  1  0
 16 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28210

> <plate>
Kinase v5-1

> <well>
J09

> <supplier_cmpd_name>
506157

> <ctcr_id>
1817

> <supplier_cmpd_id>
EMD 506157

> <smiles>
COc1cc(SC)ccc1C(=O)N2CCC(CC2)Cc3ccccc3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{JX-401,JX401,349087-34-9,349087349,"JX 401",UNII-TBU7UTV30Q,UNIITBU7UTV30Q,TBU7UTV30Q,1-(2-Methoxy-4-(methylthio)benzoyl)-4-(phenylmethyl)piperidine,1(2Methoxy4(methylthio)benzoyl)4(phenylmethyl)pipe
ridine,(4-benzylpiperidin-1-yl)(2-methoxy-4-(methylsulfanyl)phenyl)methanone,(4benzylpiperidin1yl)(2methoxy4(methylsulfanyl)phenyl)methanone,Piperidine,1-(2-methoxy-4-(methylthio)benzoyl)-4-(ph,1(2met
hoxy4(methylthio)benzoyl)4(ph,"EMD 506157",506157}

> <pdid>
PD015173

> <targets>
{"p38 MAP Kinase Inhibitor VI",JX401}

> <classes>
{}

> <pubchem_cids>
{1126109}

$$$$
UTKinase_V5
  SciTegic11012413002D

 12 13  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    2.5951   -3.0031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  7  1  0
 11 12  2  0
 12  4  1  0
M  END
> <name>
UTKinase_V5

> <id>
28211

> <plate>
Kinase v5-1

> <well>
J11

> <supplier_cmpd_name>
506158

> <ctcr_id>
6757

> <supplier_cmpd_id>
EMD 506158

> <smiles>
NC(=O)c1ccc2[nH]ccc2c1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{1H-Indole-5-carboxamide,1HIndole5carboxamide,"1H Indole 5 carboxamide",1670-87-7,1670877,"1670 87 7",Indole-5-carboxamide,Indole5carboxamide,"Indole 5 carboxamide",SD-169,SD169,"SD 169",1~(H)-indole-
5-carboxamide,1~(H)indole5carboxamide,"1~(H) in","EMD 506158",506158}

> <pdid>
PD015079

> <targets>
{"p38 MAP Kinase Inhibitor VII",SD-169,"P38 MAPK","p38 MAPK"}

> <classes>
{MAPK/ERK Pathway}

> <pubchem_cids>
{14973220}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
    1.2947   -3.7531    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -3.9021   -3.7405    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2080   -5.9890    0.0000 N   0  0
   -5.2111   -7.4899    0.0000 C   0  0
   -3.9120   -8.2400    0.0000 C   0  0
   -3.9120   -9.7400    0.0000 C   0  0
   -5.2110  -10.4900    0.0000 C   0  0
   -5.2110  -11.9900    0.0000 Br  0  0
   -6.5101   -9.7400    0.0000 C   0  0
   -6.5101   -8.2400    0.0000 C   0  0
   -7.8092   -7.4900    0.0000 N   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0127   -6.0039    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 15  1  0
 21 22  1  0
 13 23  1  0
 23 24  2  0
 24 10  1  0
 24 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28212

> <plate>
Kinase v5-1

> <well>
J13

> <supplier_cmpd_name>
506163

> <ctcr_id>
5232

> <supplier_cmpd_id>
EMD 506163

> <smiles>
Cc1ccccc1C(=O)c2ccc(Nc3ccc(Br)cc3N)cc2Cl

> <pd_targets>
{MAPK11,MAPK12,MAPK13,MAPK14}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK11,MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"EO 1428",321351-00-2,321351002,EO-1428,EO1428,UNII-MV2RHJ680O,UNIIMV2RHJ680O,MV2RHJ680O,CHEMBL347496,(4-(2-amino-4-bromoanilino)-2-chlorophenyl)-(2-methylphenyl)methanone,(4(2amino4bromoanilino)2chl
orophenyl)(2methylphenyl)methanone,(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)(2-methylphenyl)methanone,(4((2Amino4bromophenyl)amino)2chlorophenyl)(2methylphenyl)methanone,(4-((2-amino-4-bromoph
enyl)ami,(4((2amino4bromophenyl)ami,2908,"EMD 506163",506163}

> <pdid>
PD021755

> <targets>
{"MAPK Family","p38 MAPK","p38 MAP Kinase Inhibitor VIII"}

> <classes>
{}

> <pubchem_cids>
{9801969}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 40  0  0  0  0            999 V2000
    2.5741  -12.0007    0.0000 N   0  0
    2.5766  -10.5007    0.0000 C   0  0
    1.2787   -9.7486    0.0000 C   0  0
    1.2811   -8.2486    0.0000 C   0  0
    2.5814   -7.5006    0.0000 C   0  0
    3.8792   -8.2528    0.0000 C   0  0
    3.8768   -9.7528    0.0000 N   0  0
    2.5868   -5.9998    0.0000 C   0  0
    1.2903   -5.2455    0.0000 O   0  0
    3.8888   -5.2533    0.0000 N   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 O   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 N   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
 19 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 33 34  1  0
 34 26  1  0
 34 35  2  0
 35 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28213

> <plate>
Kinase v5-1

> <well>
J15

> <supplier_cmpd_name>
524611

> <ctcr_id>
1416

> <supplier_cmpd_id>
EMD 524611

> <smiles>
Nc1ccc(cn1)C(=O)Nc2cccc(c2)c3nc(N4CCOCC4)c5oc6ncccc6c5n3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{371942-69-7,371942697,YM201636,YM-201636,"YM 201636",PubChem22459,cc-386,cc386,MLS006010997,SCHEMBL258416,CHEMBL2178735,CHEBI:91382,AOB1919,DTXSID90433303,EX-A037,EXA037,QCR-257,QCR257,BCPP000006,HMS
3229J15,HMS3295C07,HMS3654F03,AMY23718,BCP01972,ABP000099,MFCD16038303,s1219,ZI,T6110,SY-YM201636,"EMD 524611",524611}

> <pdid>
PD011051

> <targets>
{PIKfyve,"PIKfyve Inhibitor",Autophagy,"Influenza Virus",PI3K}

> <classes>
{Anti-infection,Autophagy,PI3K/Akt/mTOR}

> <pubchem_cids>
{9956222}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Br  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    0.0072   -7.5017    0.0000 C   0  0
    0.0095   -9.0017    0.0000 N   0  0
    1.3026   -5.2488    0.0000 C   0  0
    2.6028   -5.9967    0.0000 O   0  0
    1.3002   -3.7488    0.0000 N   0  0
   -2.5939   -6.0054    0.0000 C   0  0
   -3.8955   -5.2596    0.0000 C   0  0
   -5.1921   -6.0137    0.0000 C   0  0
   -5.1873   -7.5137    0.0000 C   0  0
   -3.8859   -8.2595    0.0000 C   0  0
   -2.5893   -7.5054    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  3  0
 12 15  1  0
 15 16  2  0
 15 17  1  0
 17  9  1  0
 11 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28214

> <plate>
Kinase v5-1

> <well>
J17

> <supplier_cmpd_name>
526520

> <ctcr_id>
2412

> <supplier_cmpd_id>
EMD 526520

> <smiles>
Oc1ccc(Br)cc1C2=CC(=C(C#N)C(=O)N2)c3ccccc3

> <pd_targets>
{PIM1,BIRC5}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase PIM family"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Kinases (EC 2.7.x.x)","Inhibitors of apoptosis (IAP) protein family","CAMK: Calcium/calmodulin-dependent protein kinases","PIM family"}

> <pathway_reactome>
{Disease,"Cell Cycle","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"FLT3 signaling in disease","M Phase","Signaling by FLT3 ITD and TKD mutants","Mitotic 
Metaphase and Anaphase","STAT5 activation downstream of FLT3 ITD mutants","Mitotic Anaphase","Separation of Sister Chromatids"}

> <broad_targets>
{PIM1}

> <broad_moa>
{"Pim kinase inhibitor"}

> <synonyms>
{"TCS PIM-1 1","TCS PIM1 1",491871-58-0,491871580,CHEMBL391586,CHEBI:86453,MFCD00276275,3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone,3Cyano4phenyl6(3bromo6hydroxy)phenyl2(1H)pyridone,6-
(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile,6(5bromo2hydroxyphenyl)2oxo4phenyl1Hpyridine3carbonitrile,C18H11BrN2O2,3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphen,3cyano4phenyl6(3bro
mo6hydroxyphen,T2253,"EMD 526520",526520}

> <pdid>
PD004196

> <targets>
{"PIM1 Kinase Inhibitor II",Pim}

> <classes>
{JAK/STAT Signaling}

> <pubchem_cids>
{1235170}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    3.8919   -5.2525    0.0000 N   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 N   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.1884   -2.6409    0.0000 C   0  0
   -4.6234   -3.0602    0.0000 C   0  0
   -4.9781   -4.5176    0.0000 C   0  0
   -3.8933   -5.5536    0.0000 C   0  0
   -4.2480   -7.0110    0.0000 Cl  0  0
   -2.4537   -5.1320    0.0000 C   0  0
   -2.0990   -3.6745    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  6  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 15  1  0
 14 22  2  0
 22 11  1  0
 22 23  1  0
 23  8  2  0
M  END
> <name>
UTKinase_V5

> <id>
28215

> <plate>
Kinase v5-1

> <well>
J19

> <supplier_cmpd_name>
526522

> <ctcr_id>
1010

> <supplier_cmpd_id>
EMD 526522

> <smiles>
Nc1nccc(n1)c2ccc3noc(c4ccc(Cl)cc4)c3c2

> <pd_targets>
{PIM1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase PIM family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","PIM family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","FLT3 signaling in disease","Signaling by FLT3 ITD and TKD mutants","STAT5 activation downstream of FLT3 ITD
 mutants"}

> <broad_targets>
{PIM1}

> <broad_moa>
{"Pim kinase inhibitor"}

> <synonyms>
{"PIM-1 INHIBITOR 2","PIM1 INHIBITOR 2","PIM 1 INHIBITOR 2",477845-12-8,477845128,"477845 12 8","4-(3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl)pyrimidin-2-amine","4(3(4chlorophenyl)2,1benzisoxazol5yl)py
rimidin2amine","4 (3 (4 chlorophenyl) 2","1 benziso","EMD 526522",nan,526522,"PIM-1 Inhibitor2"}

> <pdid>
PD004194

> <targets>
{"PIM1 Kinase Inhibitor IV"}

> <classes>
{}

> <pubchem_cids>
{2765355}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 F   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 F   0  0
    3.8975   -2.2510    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.3786   -3.8595    0.0000 S   0  0
   -1.8371   -5.2877    0.0000 C   0  0
   -0.9513   -6.4982    0.0000 O   0  0
   -3.3371   -5.2929    0.0000 N   0  0
   -3.8056   -3.8680    0.0000 C   0  0
   -5.2311   -3.4009    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
  9 18  2  0
 18  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28216

> <plate>
Kinase v5-1

> <well>
J21

> <supplier_cmpd_name>
526523

> <ctcr_id>
7363

> <supplier_cmpd_id>
EMD 526523

> <smiles>
FC(F)(F)c1cccc(/C=C/2SC(=O)NC2=O)c1

> <pd_targets>
{PIM1,PIM2,TTR,CISD1}

> <pathway_gtopdb>
{Enzyme,"Secreted protein","Unclassified protein",Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase PIM family"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Kinases (EC 2.7.x.x)",Transthyretin,"CAMK: Calcium/calmodulin-dependent protein kinases","PIM family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by GPCR","FLT3 signaling in disease","GPCR downstream signalling","Signalin
g by FLT3 ITD and TKD mutants","G alpha (i) signalling events","STAT5 activation downstream of FLT3 ITD mutants","Visual phototransduction","The canonical retinoid cycle in rods (twilight vision)"}

> <broad_targets>
{PIM1}

> <broad_moa>
{"Pim kinase inhibitor"}

> <synonyms>
{"CS PIM1 4",438190-29-5,438190295,SMI-4a,SMI4a,"SMI 4a","TCS PIM-1 4a","TCS PIM1 4a",(Z)-SMI-4a,(Z)SMI4a,"(Z)-5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione","(Z)5(3(trifluoromethyl)benzyli
dene)thiazolidine2,4dione","(5Z)-5-(3-(trifluoromethyl)benzylidene)-1,3-thiazolidine-2,4-dione","(5Z)5(3(trifluoromethyl)benzylidene)1,3thiazolidine2,4dione",CHEMBL183906,(5Z)-5-((3-(TRIFLUOROMETHYL)P
HENYL)METHY,(5Z)5((3(TRIFLUOROMETHYL)PHENYL)METHY,SY-SMI-4a,"EMD 526523",nan,S8005,526523}

> <pdid>
PD010270

> <targets>
{PIM,Pim}

> <classes>
{}

> <pubchem_cids>
{1361334}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    3.8912   -5.2570    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -4.0317   -0.7359    0.0000 S   0  0
   -5.4979   -1.0529    0.0000 C   0  0
   -6.1032   -2.4253    0.0000 O   0  0
   -6.2524    0.2436    0.0000 N   0  0
   -5.2526    1.3618    0.0000 C   0  0
   -5.5608    2.8298    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  8 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 12  1  0
 17 18  2  0
M  END
> <name>
UTKinase_V5

> <id>
28217

> <plate>
Kinase v5-1

> <well>
L03

> <supplier_cmpd_name>
526524

> <ctcr_id>
7704

> <supplier_cmpd_id>
EMD 526524

> <smiles>
CCCOc1ccc(cc1)/C=C/2SC(=O)NC2=O

> <pd_targets>
{PIM2,PIM1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase PIM family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","PIM family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","FLT3 signaling in disease","Signaling by FLT3 ITD and TKD mutants","STAT5 activation downstream of FLT3 ITD
 mutants"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MI16,SMI-16a,SMI16a,"(5Z)-5-((4-propoxyphenyl)methylidene)-1,3-thiazolidine-2,4-dione","(5Z)5((4propoxyphenyl)methylidene)1,3thiazolidine2,4dione","(Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione"
,"(Z)5(4Propoxybenzylidene)thiazolidine2,4dione",1099596-27-6,1099596276,587852-28-6,587852286,"(5Z)-5-(4-propoxybenzylidene)-1,3-thiazolidine-2,4-dione","(5Z)5(4propoxybenzylidene)1,3thiazolidine2,4d
ione",CHEMBL84558,SCHEMBL2544367,SCHEMBL2,"EMD 526524",526524}

> <pdid>
PD015751

> <targets>
{"PIM1/2 Kinase Inhibitor VI"}

> <classes>
{}

> <pubchem_cids>
{6076476}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 25  0  0  0  0            999 V2000
   10.1969    0.3738    0.0000 Cl  0  0
    7.6969    0.3738    0.0000 Cl  0  0
    3.8919   -5.2525    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 S   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 13  1  0
 12 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 19  1  0
 23 24  2  0
 24 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28218

> <plate>
Kinase v5-1

> <well>
L05

> <supplier_cmpd_name>
528111

> <ctcr_id>
2420

> <supplier_cmpd_id>
EMD 528111

> <smiles>
Cl.Cl.Oc1cccc(c1)c2nc(N3CCOCC3)c4sccc4n2

> <pd_targets>
{PIK3C2B,PIK3CB,PIK3CG,PIK3CA,KDR,MTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","TK protein kinase group","Atypical protein kinase group","Tyrosine protein kinase VEGFR family","Atypical protein kinase PIKK family","Atypical protein kin
ase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","Receptor kinases",Atypical,"Phosphatidylinositol-4-phosphate 3-kinase family",Phosphatidylinositol-4,"5-bisph
osphate 3-kinase family","TK: Tyrosine kinase","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Receptor tyrosine kinases (RTKs)","FRAP subfamily","Type IV RTKs: VEGF (vascular endothe
lial growth factor) receptor family"}

> <pathway_reactome>
{Metabolism,"Signal Transduction",Disease,"Gene expression (Transcription)","Metabolism of lipids","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors 
and second messengers","RNA Polymerase II Transcription","Phospholipid metabolism","Signaling by Insulin receptor","Signaling by FGFR in disease","Signaling by VEGF","Generic Transcription Pathway","P
I Metabolism","Insulin receptor signalling cascade","Signaling by FGFR1 in disease","VEGFA-VEGFR2 Pathway","Transcriptional Regulation by TP53","Synthesis of PIPs at the plasma membrane","IRS-mediated
 signalling","FGFR1 mutant receptor activation","VEGFR2 mediated cell proliferation","Regulation of TP53 Activity","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expr
ession and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"PI 3-Kalpha Inhibitor IV","PI 3Kalpha Inhibitor IV",1188890-32-5,1188890325,"3-(4-Morpholinothieno(3,2-d)pyrimidin-2-yl)phenol, HCl","3(4Morpholinothieno(3,2d)pyrimidin2yl)phenol, HCl",HMS3229L05,"P
I3-Kinase |A Inhibitor 2 hydrochloride","PI3Kinase |A Inhibitor 2 hydrochloride","3-(4-(4-morpholinyl)thieno(3,2-d)pyrimidin-2-yl)-phenol,dihydrochloride","3(4(4morpholinyl)thieno(3,2d)pyrimidin2yl)ph
enol,dihydrochloride","EMD 528111",528111}

> <pdid>
PD019589

> <targets>
{"PI 3-K? Inhibitor IV"}

> <classes>
{}

> <pubchem_cids>
{16760620}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 F   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2122   -3.8625    0.0000 O   0  0
   -0.7464   -5.2884    0.0000 C   0  0
    0.7536   -5.2860    0.0000 C   0  0
    1.2149   -3.8587    0.0000 C   0  0
   -1.6226   -6.5037    0.0000 C   0  0
   -1.0080   -7.8729    0.0000 C   0  0
    0.4519   -8.1574    0.0000 S   0  0
    0.6162   -9.6484    0.0000 C   0  0
    1.9191  -10.3918    0.0000 O   0  0
   -0.7510  -10.2654    0.0000 N   0  0
   -1.7603   -9.1558    0.0000 C   0  0
   -3.2522   -9.3113    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  9  2  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 15  1  0
 20 21  2  0
M  END
> <name>
UTKinase_V5

> <id>
28219

> <plate>
Kinase v5-1

> <well>
L07

> <supplier_cmpd_name>
528112

> <ctcr_id>
7705

> <supplier_cmpd_id>
EMD 528112

> <smiles>
Oc1cc(F)ccc1c2oc(cc2)/C=C/3SC(=O)NC3=O

> <pd_targets>
{PIK3CG,PIK3CA,PIK3CB,PIK3CD,CSNK2A1,CSNK2A2,CSNK2B}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase CK2 family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{Metabolism,Disease,"Signal Transduction","Immune System","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kina
ses","Cytokine Signaling in Immune system","Phospholipid metabolism","Signaling by FGFR in disease","Signaling by Insulin receptor","Signaling by Interleukins","PI Metabolism","Signaling by FGFR1 in d
isease","Insulin receptor signalling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Synthesis of PIPs at the plasma membrane","FGFR1 mutant receptor activation","IRS-mediated signalling"
,"Interleukin receptor SHC signaling","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade"}

> <broad_targets>
{PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{S25242,AS-252424,AS252424,900515-16-4,900515164,"AS 252424",UNII-63D4RUV1GN,UNII63D4RUV1GN,63D4RUV1GN,CHEMBL379156,C14H8FNO4S,"PI 3-Kgamma/CKII Inhibitor","PI 3Kgamma/CKII Inhibitor",SCHEMBL1494573,G
TPL10578,EX-A473,EXA473,SYN1009,BCPP000387,DTXSID801017365,HMS3229L07,HMS3260O16,HMS3650K14,BCP01892,Tox21_500157,Tox21500157,Tox21-500157,"Tox21 500157","EMD 528112",528112}

> <pdid>
PD010893

> <targets>
{"PI 3-K?/CKII Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{11630874}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    2.6030   -2.9977    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    5.2003   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    7.7985   -1.4932    0.0000 C   0  0
    7.7985   -2.9932    0.0000 C   0  0
    6.4995   -3.7432    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 N   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 C   0  0
   -1.2942   -8.2509    0.0000 O   0  0
    0.0036   -7.4988    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  2 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 10  1  0
 20 14  1  0
 18 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 12 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28220

> <plate>
Kinase v5-1

> <well>
L09

> <supplier_cmpd_name>
528113

> <ctcr_id>
2097

> <supplier_cmpd_id>
EMD 528113

> <smiles>
CC(Nc1ccccc1)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C

> <pd_targets>
{PIK3CB,CLK4,PIK3CA,PIK3CD,CSNK1A1,PTK2,PIK3CG}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","CMGC protein kinase group","CK1 protein kinase group","TK protein kinase group","CMGC protein kinase CLK family","CK1 protein kinase CK1 family","Tyrosine 
protein kinase Fak family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","Receptor kinases",Phosphatidylinositol
-4,"5-bisphosphate 3-kinase family","CLK family","Casein kinase 1 (CK1) family","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Fak family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System",Metabolism,"Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signalin
g in Immune system","Infectious disease","Metabolism of lipids","Signaling by Insulin receptor","Signaling by FGFR in disease","Signaling by Interleukins","Signaling by WNT in cancer","Leishmania infe
ction","Phospholipid metabolism","Insulin receptor signalling cascade","Signaling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Signaling by AMER1 mutants","Parasite infecti
on","PI Metabolism","IRS-mediated signalling","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","Truncations of AMER1 destabilize the destruction complex","Leishmania phagocytosi
s","Synthesis of PIPs at the plasma membrane","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","FCGR3A-mediated phagocytosis"}

> <broad_targets>
{PIK3CB,PIK3CD}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{GX22,TGX-221,TGX221,663619-89-4,663619894,"Tgx 221",CHEMBL1972466,"9-(1-Anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido(1,2-a)pyrimidin-4-one","9(1Anilinoethyl)7methyl2morpholin4ylpyrido(1,2a)pyrimidin
4one",Kinome_3610,Kinome3610,Kinome-3610,"Kinome 3610",PubChem22489,cc-494,cc494,MLS006010987,SCHEMBL902952,GTPL8244,CHEBI:91428,AOB3924,QCR-207,QCR207,SYN1089,BCPP000046,HMS322,T2661,S1169,"EMD 52811
3",528113,"TGX 221"}

> <pdid>
PD003688

> <targets>
{TGX221,TGX-221,"PI3K BETA","PI 3-K? Inhibitor VI"}

> <classes>
{}

> <pubchem_cids>
{9907093}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 19  0  0  0  0            999 V2000
    0.9513   -6.4982    0.0000 O   0  0
    1.8372   -5.2877    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    3.8056   -3.8679    0.0000 C   0  0
    5.2311   -3.4009    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.3786   -3.8595    0.0000 S   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 O   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  2  1  0
  6  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 12  1  0
 16 17  2  0
 17  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28221

> <plate>
Kinase v5-1

> <well>
L11

> <supplier_cmpd_name>
528114

> <ctcr_id>
7706

> <supplier_cmpd_id>
EMD 528114

> <smiles>
O=C1NC(=O)\C(S1)=C\c2ccc3OCOc3c2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ST025554,"5-(2H-benzo(3,4-d)1,3-dioxolen-5-ylmethylene)-1,3-thiazolidine-2,4-dione","5(2Hbenzo(3,4d)1,3dioxolen5ylmethylene)1,3thiazolidine2,4dione","5 (2H benzo(3,4 d)1,3 dioxolen 5 ylmethylene) 1,3
 thiazolidine 2,4 dione",AS-041164,AS041164,AS,"EMD 528114",528114}

> <pdid>
PD021182

> <targets>
{"PI 3-K? Inhibitor VII"}

> <classes>
{}

> <pubchem_cids>
{1269519}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 29  0  0  0  0            999 V2000
    9.5296    5.3036    0.0000 C   0  0
    8.5280    6.4202    0.0000 C   0  0
    7.0602    6.1110    0.0000 C   0  0
    6.0585    7.2276    0.0000 C   0  0
    6.5247    8.6533    0.0000 C   0  0
    7.9925    8.9625    0.0000 C   0  0
    8.9942    7.8459    0.0000 C   0  0
    5.5249    9.7726    0.0000 N   0  3
    5.9931   11.1977    0.0000 O   0  0
    4.0565    9.4660    0.0000 O   0  5
    6.5937    4.6845    0.0000 S   0  0
    7.5957    3.5683    0.0000 O   0  0
    6.1282    3.2586    0.0000 O   0  0
    5.1253    4.3743    0.0000 N   0  0
    4.1233    5.4906    0.0000 C   0  0
    4.6588    2.9478    0.0000 N   0  0
    3.1904    2.6376    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Br  0  0
   17.0301    4.8492    0.0000 O   0  0
   14.5301    4.8492    0.0000 O   0  0
   12.0301    4.8492    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  3
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  1  0
  3 11  1  0
 11 12  2  0
 11 13  2  0
 11 14  1  0
 14 15  1  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  2  3
 21 22  1  0
 22 18  1  0
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  3
 26 21  1  0
 24 27  1  0
M  CHG  2   8   1  10  -1
M  END
> <name>
UTKinase_V5

> <id>
28222

> <plate>
Kinase v5-1

> <well>
L13

> <supplier_cmpd_name>
528116

> <ctcr_id>
7707

> <supplier_cmpd_id>
EMD 528116

> <smiles>
CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.O.O.Cl

> <pd_targets>
{PIK3CA,PIK3CD,CDK7,CDK9,PIK3CB,PIK3C2B,FLT3,CDK2,PIK3CG,GSK3B,PRKDC,CCNT1}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","CMGC protein kinase group","TK protein kinase group","Atypical protein kinase group","CMGC protein kinase CDK family","Tyrosine protein kinase PDGFR family
","CMGC protein kinase GSK family","Atypical protein kinase PIKK family","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases",Atypical,Phosphatidylinositol-4,"5-bisphosp
hate 3-kinase family","Cyclin-dependent kinase (CDK) family","Phosphatidylinositol-4-phosphate 3-kinase family","TK: Tyrosine kinase","Glycogen synthase kinase (GSK) family","Phosphatidyl inositol 3' 
kinase-related kinases (PIKK) family","CDK7 subfamily","CDK9 subfamily","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","GSK subfamily","Other PIKK family kinases","Type III RTKs: PDGFR",CSFR,Kit,
"FLT3 receptor family"}

> <pathway_reactome>
{Disease,"Immune System","Signal Transduction",Metabolism,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Im
mune system","Infectious disease","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","RNA Polymerase II Transcription","Innate Immune System","Signaling by FGFR in disease","Signaling by 
Interleukins","HIV Infection","Signaling by Insulin receptor","Phospholipid metabolism","Generic Transcription Pathway","SARS-CoV Infections","Cytosolic sensors of pathogen-associated DNA","Signaling 
by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","HIV Life Cycle","Insulin receptor signalling cascade","PI Metabolism","Transcriptional Regulation by TP53","SARS-CoV-1 Infectio
n","STING mediated induction of host immune responses","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","Late Phase of HIV Life Cycle","IRS-mediated signalling","Synthesis of PI
Ps at the plasma membrane","Regulation of TP53 Activity","SARS-CoV-1 Genome Replication and Transcription","IRF3-mediated induction of type I IFN","Signaling by cytosolic FGFR1 fusion mutants","Transc
ription of the HIV genome","PI3K Cascade","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-1 genome","HIV Transcription Elongation","Regulation of TP53 Degradation","Tat-me
diated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC}

> <broad_moa>
{"DNA protein kinase inhibitor","PI3K inhibitor"}

> <synonyms>
{HMS3229L13,"EMD 528116",528116}

> <pdid>
PD016738

> <targets>
{PIK75}

> <classes>
{}

> <pubchem_cids>
{42622917}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -3.8813    1.4408    0.0000 C   0  0
   -5.0460    2.3579    0.0000 S   0  0
   -6.2823    1.5084    0.0000 C   0  0
   -7.6935    2.0116    0.0000 C   0  0
   -8.8360    1.0396    0.0000 N   0  0
   -7.9646    3.4869    0.0000 O   0  0
   -5.8565    0.0701    0.0000 C   0  0
   -6.7662   -1.1203    0.0000 O   0  0
   -6.1900   -2.5061    0.0000 C   0  0
   -7.1014   -3.6986    0.0000 C   0  0
   -6.5275   -5.0845    0.0000 C   0  0
   -7.4407   -6.2745    0.0000 C   0  0
   -8.9279   -6.0786    0.0000 C   0  0
   -9.5018   -4.6927    0.0000 C   0  0
   -8.5886   -3.5028    0.0000 C   0  0
   -9.8416   -7.2692    0.0000 S   0  0
  -11.3287   -7.0728    0.0000 C   0  0
   -9.2686   -8.6554    0.0000 O   0  0
  -10.7554   -8.4587    0.0000 O   0  0
   -4.3570    0.0307    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 11 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 21 24  1  0
 24 25  1  0
 24 26  2  0
 24 27  2  0
 15 28  1  0
 28  9  2  0
  8 29  1  0
 29  5  2  0
 29 30  1  0
 30 31  2  0
 31  3  1  0
 31 32  1  0
 32 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28223

> <plate>
Kinase v5-1

> <well>
L15

> <supplier_cmpd_name>
528282

> <ctcr_id>
2610

> <supplier_cmpd_id>
EMD 528282

> <smiles>
COc1cc2ncn(c3sc(C(N)=O)c(OCc4ccc(cc4)[S](C)(=O)=O)c3)c2cc1OC

> <pd_targets>
{PLK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase PLK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Polo-like kinase (PLK) family"}

> <pathway_reactome>
{"Cell Cycle",Mitotic,"Mitotic G2-G2/M phases","G2/M Transition","Centrosome maturation","Loss of proteins required for interphase microtubule organization from the centrosome","Loss of Nlp from mitot
ic centrosomes"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{916985-21-2,916985212,CAY10575,"CAY 10575",CHEMBL219899,"BMCL191018 Compound 39",BDBM27444,CHEBI:94170,DTXSID80648989,HMS3229L15,1423AH,ZINC19795632,AKOS016361157,"benzimidazole-thiophene carboxamide
, 2","benzimidazolethiophene carboxamide, 2",BRD-K08451418-001-01-6,BRDK08451418001016,Q27165918,"EMD 528282",528282}

> <pdid>
PD015665

> <targets>
{"Polo-like Kinase Inhibitor I"}

> <classes>
{}

> <pubchem_cids>
{25190912}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    1.8073   -5.7196    0.0000 N   0  0
    2.5551   -4.4192    0.0000 C   0  0
    4.0551   -4.4171    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  3
   -0.6923   -4.0811    0.0000 O   0  5
   -2.5988    1.5004    0.0000 C   0  0
   -3.8978    2.2504    0.0000 N   0  0
    2.5972    1.5031    0.0000 N   0  3
    3.8976    0.7554    0.0000 O   0  5
    2.5951    3.0031    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
 12  4  2  0
 12 13  1  0
  9 14  1  0
 14 15  3  0
  7 16  1  0
 16 17  1  0
 16 18  2  0
M  CHG  4  12   1  13  -1  16   1  17  -1
M  END
> <name>
UTKinase_V5

> <id>
28224

> <plate>
Kinase v5-1

> <well>
L17

> <supplier_cmpd_name>
528283

> <ctcr_id>
4387

> <supplier_cmpd_id>
EMD 528283

> <smiles>
NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O

> <pd_targets>
{PLK1,MTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Atypical protein kinase group","Other protein kinase PLK family","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfa
mily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases",Atypical,"Other protein kinases","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Polo-like kinase (P
LK) family","FRAP subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Mitotic,"RNA Polymerase II Transcription","Mitotic G2-G2/M phases","Generic Transcription Pathway","G2/M Transition","Transcriptional Regulation by TP53
","Centrosome maturation","Regulation of TP53 Activity","Loss of proteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Expression and Degradation","Loss of
 Nlp from mitotic centrosomes","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"2-Carbamoyl-5-cyano-7-nitrobenzo(d)thiazole 3-oxide","2Carbamoyl5cyano7nitrobenzo(d)thiazole 3oxide",BTO-1,BTO1,40647-02-7,40647027,"5-Cyano-7-nitro-3-oxido-1,3-benzothiazol-3-ium-2-carboxamide","5C
yano7nitro3oxido1,3benzothiazol3ium2carboxamide",CHEMBL492008,"Polo-like Kinase Inhibitor II, BTO-1","Pololike Kinase Inhibitor II, BTO1","5-Cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide",
"5Cyano7nitro3oxybenzothiazole2carboxylic acid amide","EMD 528283",528283}

> <pdid>
PD002791

> <targets>
{"Polo-like Kinase Inhibitor II",BTO-1}

> <classes>
{}

> <pubchem_cids>
{9548007}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 43  0  0  1  0            999 V2000
   -1.7668    6.0997    0.0000 C   0  0
   -2.5381    4.8132    0.0000 N   0  0
   -1.8100    3.5000    0.0000 C   0  0  2  0  0  0
   -0.2400    3.5200    0.0000 C   0  0
    0.5000    2.1800    0.0000 C   0  0  1  0  0  0
   -1.0600    2.1800    0.0000 O   0  0
   -1.8300    0.9300    0.0000 C   0  0  1  0  0  0
   -3.1401    0.1996    0.0000 C   0  0
   -2.6500    2.2500    0.0000 C   0  0  2  0  0  0
   -4.1488    2.2849    0.0000 O   0  0
   -4.9300    1.0044    0.0000 C   0  0
   -0.9800   -0.7800    0.0000 N   0  0
   -2.1300   -1.4600    0.0000 C   0  0
   -3.3200   -0.7600    0.0000 C   0  0
   -4.5500   -1.4800    0.0000 C   0  0
   -4.5800   -2.7700    0.0000 C   0  0
   -3.3400   -3.4700    0.0000 C   0  0
   -2.1300   -2.7900    0.0000 C   0  0
    0.2400   -2.7700    0.0000 C   0  0
    1.4300   -3.4700    0.0000 C   0  0
    1.7600   -4.9700    0.0000 C   0  0  2  0  0  0
    0.7780   -6.1039    0.0000 O   0  0
    3.2600   -5.0800    0.0000 N   0  0
    3.8500   -3.6300    0.0000 C   0  0
    5.2941   -3.2244    0.0000 O   0  0
    2.6600   -2.7500    0.0000 C   0  0
    2.6800   -1.4600    0.0000 C   0  0
    3.7900    0.5600    0.0000 C   0  0
    4.9600    1.2800    0.0000 C   0  0
    4.9600    2.6300    0.0000 C   0  0
    3.8100    3.2900    0.0000 C   0  0
    2.6400    2.5900    0.0000 C   0  0
    2.6400    1.2400    0.0000 C   0  0
    1.4900    0.5400    0.0000 N   0  0
    1.4500   -0.7600    0.0000 C   0  0
    0.2400   -1.4400    0.0000 C   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  5  4  1  6
  5  6  1  0
  6  7  1  0
  7  8  1  1
  7  9  1  0
  9  3  1  0
  9 10  1  6
 10 11  1  0
  7 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  1
 21 23  1  0
 23 24  1  0
 24 25  2  0
 24 26  1  0
 26 20  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 33 34  1  0
 34  5  1  0
 34 35  1  0
 35 27  1  0
 35 36  2  0
 36 12  1  0
 36 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28225

> <plate>
Kinase v5-1

> <well>
L19

> <supplier_cmpd_name>
539644

> <ctcr_id>
7708

> <supplier_cmpd_id>
EMD 539644

> <smiles>
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6[C@H](O)NC(=O)c6c7c8ccccc8n2c7c35

> <pd_targets>
{PRKCA,PRKCD,CHEK2,PRKCE,PRKCB,CDK1,LCK,MARK1,GSK3B,PRKACA,PRKACB,PRKAR1A,PRKAR1B,PRKAR2A,PRKAR2B,PRKCG,CHEK1,MAPK14,PDPK1,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,CDK2,PRKACG,CDK4,CDK6}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","CAMK protein kinase group","CMGC protein kinase group","TK protein kinase group","AGC protein kinase PKC family","CAMK protein kinase RAD53 
family","CMGC protein kinase CDK family","Tyrosine protein kinase Src family","CAMK protein kinase CAMK1 family","CMGC protein kinase GSK family","CMGC protein kinase MAPK family","AGC protein kinase 
PDK1 subfamily","AGC protein kinase PKC alpha subfamily","AGC protein kinase PKC delta subfamily","AGC protein kinase PKC eta subfamily","CMGC protein kinase CDC2 subfamily","CAMK protein kinase MARK 
subfamily","CAMK protein kinase CHK1 subfamily","CMGC protein kinase p38 subfamily","AGC protein kinase PKA family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK fami
lies","Receptor kinases","Protein kinase C (PKC) family","CAMK-like (CAMKL) family","Cyclin-dependent kinase (CDK) family","TK: Tyrosine kinase","Glycogen synthase kinase (GSK) family","Protein kinase
 A (PKA) family","Mitogen-activated protein kinases (MAP kinases)","PDK1 family","Delta subfamily","CHK1 subfamily","Eta subfamily","Alpha subfamily","CDK1 subfamily","Non-receptor tyrosine kinases (n
RTKs)","MARK subfamily","GSK subfamily","p38 subfamily","Src family","CDK4 subfamily"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Immune System","Cell Cycle",Disease,"Neuronal System","DNA Repair","Signaling by GPCR","Intracellular signaling by second messengers","RNA Pol
ymerase II Transcription","Innate Immune System",Mitotic,"Infectious disease","Transmission across Chemical Synapses","DNA Double-Strand Break Repair","GPCR downstream signalling","DAG and IP3 signali
ng","Generic Transcription Pathway","Fcgamma receptor (FCGR) dependent phagocytosis","M Phase","Regulation of mitotic cell cycle","HIV Infection","SARS-CoV Infections","Neurotransmitter receptors and 
postsynaptic signal transmission","Homology Directed Repair","Toll-like Receptor Cascades","G alpha (i) signalling events","CaM pathway","Transcriptional Regulation by TP53","Role of phospholipids in 
phagocytosis","Mitotic Prophase","APC/C-mediated degradation of cell cycle proteins","Host Interactions of HIV factors","SARS-CoV-1 Infection","Glutamate binding","activation of AMPA receptors and syn
aptic plasticity","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Toll Like Receptor 5 (TLR5) Cascade","Visual phototransduction","Calmodulin induced events","Regulation
 of TP53 Activity","Nuclear Envelope Breakdown","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","The role of Nef in HIV-1 replication and disease pathogenesis","SARS-CoV
-1 Genome Replication and Transcription","Trafficking of AMPA receptors","HDR through Homologous Recombination (HRR)","MyD88 cascade initiated on plasma membrane","The phototransduction cascade","Regu
lation of TP53 Expression and Degradation","Depolymerisation of the Nuclear Lamina","APC/C:Cdc20 mediated degradation of mitotic proteins","Nef-mediates down modulation of cell surface receptors by re
cruiting them to clathrin adapters","Replication of the SARS-CoV-1 genome","Trafficking of GluR2-containing AMPA receptors","Homologous DNA Pairing and Strand Exchange","MAP kinase activation",Inactiv
ation,"recovery and regulation of the phototransduction cascade","Regulation of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoi
nt","Nef Mediated CD4 Down-regulation","Presynaptic phase of homologous DNA pairing and strand exchange","MAPK targets/ Nuclear events mediated by MAP kinases","Cdc20:Phospho-APC/C mediated degradatio
n of Cyclin A","Activation of the AP-1 family of transcription factors","Mitotic G1 phase and G1/S transition","G1 Phase","Cyclin D associated events in G1"}

> <broad_targets>
{CDK1,CHEK1,CHEK2,GSK3B,LCK,MAPK14,MARK1,MARK3,PDPK1,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG}

> <broad_moa>
{"CDK inhibitor","CHK inhibitor","PKC inhibitor"}

> <synonyms>
{"UCN 02",UCN-01,UCN01,UCN-02,UCN02,CHEMBL574737,KW-2401,KW2401,KRX-0601,KRX0601,121569-61-7,121569617,SCHEMBL16946789,DTXSID60923867,HMS3229L19,BDBM50280450,NSC800958,ZINC33901069,NSC-800958,NCGC0034
6827-02,NCGC0034682702,"UCN-01, >=97 (HPLC), powder","UCN01, >=97 (HPLC), powder",HY-108262,HY108262,CS-0027882,CS0027882,"EMD 539644",539644}

> <pdid>
PD016168

> <targets>
{UCN-01}

> <classes>
{}

> <pubchem_cids>
{3078519}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    3.8919   -5.2525    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  5  9  1  0
  9 10  2  3
 10 11  1  0
 10 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  1  0
 17 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 22 14  1  0
 22 23  1  0
 23  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28226

> <plate>
Kinase v5-1

> <well>
L21

> <supplier_cmpd_name>
551590

> <ctcr_id>
1028

> <supplier_cmpd_id>
EMD 551590

> <smiles>
Oc1ccc(cc1O)C2=C(O)C(=O)c3c(O)c(O)c(O)cc3O2

> <pd_targets>
{PIM1,POL,CD38,AURKB,AMY1A,SYN1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein",Kinase,Hydrolase,"Protein Kinase","CAMK protein kinase group","Other protein kinase group","CAMK protein kinase PIM family","Other protein kinase AUR family"}

> <pathway_chembl>
{Enzymes,"Other protein targets",Receptors,"Kinases (EC 2.7.x.x)","Abscisic acid receptor complex","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","PIM fa
mily","Other protein kinases","Aurora kinase (Aur) family"}

> <pathway_reactome>
{Disease,Metabolism,"Cell Cycle","Neuronal System","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of vitamins and cofactors",Mitotic,"Transmission acros
s Chemical Synapses","FLT3 signaling in disease","Metabolism of water-soluble vitamins and cofactors","M Phase","Neurotransmitter release cycle","Signaling by FLT3 ITD and TKD mutants","Nicotinate met
abolism","Mitotic Metaphase and Anaphase","Dopamine Neurotransmitter Release Cycle","STAT5 activation downstream of FLT3 ITD mutants","Mitotic Anaphase","Separation of Sister Chromatids"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Quercetagetin,90-18-6,90186,6-Hydroxyquercetin,6Hydroxyquercetin,Quercetagenin,"3,3',4',5,6,7-Hexahydroxyflavone","3,3',4',5,6,7Hexahydroxyflavone",UNII-SV68G507VO,UNIISV68G507VO,"2-(3,4-Dihydroxyphe
nyl)-3,5,6,7-tetrahydroxy-4H-chromen-4-one","2(3,4Dihydroxyphenyl)3,5,6,7tetrahydroxy4Hchromen4one",CHEBI:8695,CHEMBL413552,SV68G507VO,2-(3,2(3,4-Dihydroxyphenyl)-3,4Dihydroxyphenyl)3,5,6,7-tetrahydro
,7tetrahydro,"EMD 551590",551590}

> <pdid>
PD017420

> <targets>
{Quercetagetin}

> <classes>
{}

> <pubchem_cids>
{5281680}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.3229    1.2135    0.0000 N   0  0
   -6.2045    0.0000    0.0000 N   0  0
   -5.3228   -1.2136    0.0000 C   0  0
   -5.7862   -2.6402    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5950   -3.0008    0.0000 N   0  0
   -1.2942   -3.7494    0.0000 C   0  0
   -1.2911   -5.2502    0.0000 C   0  0
    0.0098   -5.9988    0.0000 O   0  0
    0.0129   -7.4996    0.0000 C   0  0
    1.3137   -8.2481    0.0000 C   0  0
    1.3168   -9.7481    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13  8  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 14 22  1  0
 22  6  1  0
 22 23  2  0
 23  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28227

> <plate>
Kinase v5-1

> <well>
N03

> <supplier_cmpd_name>
553509

> <ctcr_id>
2314

> <supplier_cmpd_id>
EMD 553509

> <smiles>
COc1ccc2nc3[nH]nc(C)c3c(NCCOCCO)c2c1

> <pd_targets>
{NUDT1}

> <pathway_gtopdb>
{Enzyme,Hydrolase}

> <pathway_chembl>
{}

> <pathway_reactome>
{Metabolism,"Metabolism of nucleotides","Nucleobase catabolism","Purine catabolism","Phosphate bond hydrolysis by NUDT proteins"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{171927-40-5,171927405,"171927 40 5",SCH-51344,SCH51344,"SCH 51344","Ras/Rac Transformation Blocker, SCH 51344",CHEMBL3793901,CHEBI:77556,AOB6629,DTXSID10433926,HMS3229N03,HMS3674M09,BCP17385,EX-A4182
,EXA4182,"EX A4182",ZINC1545892,BDBM50162076,AKOS,"EMD 553509",553509}

> <pdid>
PD017615

> <targets>
{"Ras/Rac Transformation Blocker","SCH 51344"}

> <classes>
{}

> <pubchem_cids>
{9995890}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 C   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -5.2096    5.9863    0.0000 N   0  0
   -5.2172    7.4863    0.0000 C   0  0
   -6.5200    8.2297    0.0000 C   0  0
   -7.8153    7.4732    0.0000 O   0  0
   -7.8077    5.9732    0.0000 C   0  0
   -6.5049    5.2298    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
 10 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29  8  1  0
 29 25  2  0
M  END
> <name>
UTKinase_V5

> <id>
28228

> <plate>
Kinase v5-1

> <well>
N05

> <supplier_cmpd_name>
554717

> <ctcr_id>
5474

> <supplier_cmpd_id>
EMD 554717

> <smiles>
C1CCC(CC1)Nc2nc(Nc3ccc(cc3)N4CCOCC4)nc5[nH]cnc25

> <pd_targets>
{MAP2K1,FFP,RORC,AURKB,TTK,AURKA,KMT2A,MEN1,ADORA3}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator","Membrane receptor",Kinase,Transferase,"Nuclear receptor",Reader,"Family A G protein-coupled receptor","Protein Kinase","Nuclear hormone receptor 
subfamily 1",Bromodomain,"Small molecule receptor (family A GPCR)","STE protein kinase group","Nuclear hormone receptor subfamily 1 group F","Other protein kinase group","Nucleotide-like receptor (fam
ily A GPCR)","STE protein kinase STE7 family","Nuclear hormone receptor subfamily 1 group F member 3","Other protein kinase AUR family","Other protein kinase TTK family","Adenosine receptor"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Catalytic receptors","G protein-coupled receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","1F. Reti
noic acid-related orphans","Receptor kinases","Adenosine receptors","STE7 family","Other protein kinases","Aurora kinase (Aur) family","TTK family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Cell Cycle","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription",Mitotic,"Signaling by GPCR","Signaling by NTRKs","Gener
ic Transcription Pathway","M Phase","GPCR ligand binding","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX3","Mitotic Metaphase and Anaphase","Transcriptional Regulation by TP53","Class
 A/1 (Rhodopsin-like receptors)","Signalling to ERKs","RUNX3 Regulates Immune Response and Cell Migration","Mitotic Anaphase","Regulation of TP53 Activity","Nucleotide-like (purinergic) receptors","Pr
olonged ERK activation events","Separation of Sister Chromatids","Regulation of TP53 Activity through Phosphorylation","Adenosine P1 receptors","Frs2-mediated activation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Reversine,656820-32-5,656820325,"656820 32 5",2-(4-Morpholinoanilino)-6-cyclohexylaminopurine,2(4Morpholinoanilino)6cyclohexylaminopurine,"2 (4 Morpholinoanilino) 6 cyclohexylaminopurine",UNII-Z499CL
J023,UNIIZ499CLJ023,"UNII Z499CLJ023",CHEMBL18834,S7588,"EMD 554717",554717}

> <pdid>
PD005329

> <targets>
{Reversine,"Adenosine Receptor","Aurora Kinase",Autophagy}

> <classes>
{GPCR & G Protein,Autophagy,Cell Cycle/DNA Damage,Epigenetics}

> <pubchem_cids>
{210332}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 24  0  0  1  0            999 V2000
   17.1347   -0.9887    0.0000 Cl  0  5
   14.6347   -0.9887    0.0000 Cl  0  5
    2.4090    1.3091    0.0000 C   0  0
    3.8022    0.7533    0.0000 C   0  0  1  0  0  0
    4.9024    1.7729    0.0000 C   0  0
    6.3855    1.5484    0.0000 N   0  0
    7.1347    0.2489    0.0000 C   0  0
    6.5858   -1.1471    0.0000 C   0  0
    5.1522   -1.5883    0.0000 C   0  0
    3.8990   -0.7508    0.0000 N   0  0
    2.5988   -1.5004    0.0000 S   0  0
    2.5983   -3.0004    0.0000 O   0  0
    3.8975   -2.2510    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    1.2991   -3.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   12.1347   -0.9887    0.0000 H   0  3
    9.6347   -0.9887    0.0000 H   0  3
  4  3  1  1
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10  4  1  0
 10 11  1  0
 11 12  2  0
 11 13  2  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 24 14  1  0
 24 18  1  0
M  CHG  4   1  -1   2  -1  25   1  26   1
M  END
> <name>
UTKinase_V5

> <id>
28229

> <plate>
Kinase v5-1

> <well>
N07

> <supplier_cmpd_name>
555550

> <ctcr_id>
6995

> <supplier_cmpd_id>
EMD 555550

> <smiles>
[Cl-].[Cl-].C[C@H]1CNCCCN1[S](=O)(=O)c2cccc3cncc(C)c23.[H+].[H+]

> <pd_targets>
{ROCK1,PRKACA,PRKACB,PRKACG,MYLK,LRRK2,ROCK2,CDK2,AURKB,MAP4K2,PDPK1,DCLK1,BRSK1,PLK4,MAP4K4,PHKG2,KDR,AURKA,PRKX,CDK5,SGK2,MARK3,EPHA2,PRKD2,PRKCZ,PRKAA1,PRKG1,MKNK2,CLK4,STK3,LCK,FGFR1,PRKD3,CHEK2,M
ARK2,PRKG2,PRKCD,MINK1,IRAK1,SLK,CLK2,AKT3,PKN2,LIMK1,FLT4,CDK1,AKT1,MAP4K5}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","CAMK protein kinase group","TKL protein kinase group","CMGC protein kinase group","Other protein kinase group","STE protein kinase group","T
K protein kinase group","AGC protein kinase DMPK family","AGC protein kinase PKA family","CAMK protein kinase MLCK family","TKL protein kinase LRRK family","CMGC protein kinase CDK family","Other prot
ein kinase AUR family","STE protein kinase STE20 family","AGC protein kinase PDK1 subfamily","CAMK protein kinase DCAMK1 family","CAMK protein kinase CAMK1 family","Other protein kinase PLK family","C
AMK protein kinase PHk family","Tyrosine protein kinase VEGFR family","AGC protein kinase SGK family","Tyrosine protein kinase Eph family","CAMK protein kinase PKD family","AGC protein kinase PKC fami
ly","AGC protein kinase PKG family","CAMK protein kinase MAPKAPK family","CMGC protein kinase CLK family","Tyrosine protein kinase Src family","Tyrosine protein kinase FGFR family","CAMK protein kinas
e RAD53 family","TKL protein kinase IRAK family","AGC protein kinase AKT family","AGC protein kinase PKN family","TKL protein kinase LISK family","AGC protein kinase ROCK subfamily","CMGC protein kina
se CDC2 subfamily","STE protein kinase KHS subfamily","CAMK protein kinase BRSK subfamily","STE protein kinase MSN subfamily","CMGC protein kinase CDK5 subfamily","CAMK protein kinase MARK subfamily",
"AGC protein kinase PKC iota subfamily","CAMK protein kinase AMPK subfamily","CAMK protein kinase MNK subfamily","STE protein kinase MST subfamily","AGC protein kinase PKC delta subfamily","STE protei
n kinase SLK subfamily","TKL protein kinase LIMK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","CMGC: Containing CDK",
MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","DMPK family","Myosin Light Chain Kinase (MLCK) family","TKL: Tyrosine kinase-like","Cyclin-dependent kina
se (CDK) family","Other protein kinases","STE20 family","PDK1 family","DCAMKL family","CAMK-like (CAMKL) family","Phosphorylase kinase (PHK) family","TK: Tyrosine kinase","Protein kinase A (PKA) famil
y","SGK family","Protein kinase D (PKD) family","Protein kinase C (PKC) family","Protein kinase G (PKG) family","MAPK-Activated Protein Kinase (MAPKAPK) family","CLK family","Akt (Protein kinase B","P
KB) family","Protein kinase N (PKN) family","Rho kinase","Leucine-rich repeat kinase (LRRK) family","CDK1 subfamily","Aurora kinase (Aur) family","KHS subfamily","BRSK subfamily","Polo-like kinase (PL
K) family","MSN subfamily","Receptor tyrosine kinases (RTKs)","CDK5 subfamily","MARK subfamily","Iota subfamily","AMPK subfamily","MKN subfamily","MST subfamily","Non-receptor tyrosine kinases (nRTKs)
","CHK1 subfamily","Delta subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","SLK subfamily","LIM domain kinase (LISK) family","Type IV RTKs: VEGF (vascular endothelial growth factor)
 receptor family","Type XIII RTKs: Ephrin receptor family","Src family","Type V RTKs: FGF (fibroblast growth factor) receptor family","LIMK subfamily"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction","Gene expression (Transcription)","Cell Cycle","Cellular responses to external stimuli",Metabolism,Disease,"Transport of small molecules",Hemostasis,"Imm
une System","Nervous system development","Signaling by Rho GTPases","Signaling by Non-Receptor Tyrosine Kinases","RNA Polymerase II Transcription",Mitotic,"Cellular responses to stress","Metabolism of
 carbohydrates","Signaling by Receptor Tyrosine Kinases","Infectious disease","Ion channel transport","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of 
lipids","Signaling by Nuclear Receptors","Platelet homeostasis","Signaling by Hippo","MAPK family signaling cascades","Intracellular signaling by second messengers","Innate Immune System","Axon guidan
ce","RHO GTPase Effectors","Signaling by PTK6","Generic Transcription Pathway","M Phase","Mitotic G2-G2/M phases","Cellular Senescence","Glycogen metabolism","Signaling by VEGF","Leishmania infection"
,"Stimuli-sensing channels","Oncogenic MAPK signaling","Sphingolipid metabolism","ESR-mediated signaling","Nitric oxide stimulates guanylate cyclase","HIV Infection","Signaling by FGFR in disease","MA
PK1/MAPK3 signaling","DAG and IP3 signaling","Toll-like Receptor Cascades","Regulation of mitotic cell cycle","Semaphorin interactions","RHO GTPases activate PAKs","PTK6 promotes HIF1A stabilization",
"Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase","G2/M Transition","Oxidative Stress Induced Senescence","Glycogen breakdown (glycogenolysis)","VEGFA-VEGFR2 Pathway","Leishmania p
arasite growth and survival","Signaling by RAS mutants","EPH-Ephrin signaling","Sphingolipid de novo biosynthesis","Extra-nuclear estrogen signaling","cGMP effects","Host Interactions of HIV factors",
"Signaling by FGFR1 in disease","RAF/MAP kinase cascade","CaM pathway","Toll Like Receptor 5 (TLR5) Cascade","RHO GTPases activate PKNs","VEGF ligand-receptor interactions","APC/C-mediated degradation
 of cell cycle proteins","Sema4D in semaphorin signaling","Regulation of TP53 Activity","Mitotic Anaphase","Centrosome maturation","VEGFR2 mediated cell proliferation","Anti-inflammatory response favo
uring Leishmania parasite infection","Signaling downstream of RAS mutants","EPHA-mediated growth cone collapse","Estrogen-stimulated signaling through PRKCZ","The role of Nef in HIV-1 replication and 
disease pathogenesis","FGFR1 mutant receptor activation","RAS processing","Calmodulin induced events","MyD88 cascade initiated on plasma membrane","VEGF binds to VEGFR leading to receptor dimerization
","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Expression and Degradation","Separation of
 Sister Chromatids","Loss of proteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Activity through Phosphorylation","ADORA2B mediated anti-inflammatory cy
tokines production","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Signaling by activated point mutants of FGFR1","MAP kinase activation","APC/C:Cdc2
0 mediated degradation of mitotic proteins","Regulation of TP53 Degradation","Loss of Nlp from mitotic centrosomes","Nef Mediated CD4 Down-regulation","activated TAK1 mediates p38 MAPK activation","AP
C:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"H-1152 Dihydrochloride","H-1152 (dihydrochloride)",871543-07-6,H1152,C16H21N3O2S.2HCl,"(S)-H-1152 (hydrochloride)","H 1152 dichloride","H1152 dihydrochloride","brd7446 dihydrochloride","H 1152 dihyd
rochloride",SCHEMBL507871,"dimethyl fasudil dihydrochloride",DTXSID90880075,SYN1221,CHEBI:137694,BCP25257,1781AH,HY-15720A,AKOS024457084,CS-1537,AS-16347,W-5335,SR-00000001484,SR-00000001484-1,"EMD 55
5550",555550}

> <pdid>
PD004930

> <targets>
{ROCK,"Rho Kinase Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{11560225}

$$$$
UTKinase_V5
  SciTegic11012413002D

 19 20  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7545    0.0000 O   0  0
   -5.2003    1.4932    0.0000 N   0  0
   -6.4990    0.7409    0.0000 C   0  0
   -7.8007    1.4864    0.0000 C   0  0
   -9.0971    0.7319    0.0000 C   0  0
   -9.0919   -0.7681    0.0000 N   0  0
   -7.7903   -1.5136    0.0000 C   0  0
   -6.4939   -0.7591    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Cl  0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
  6 17  1  0
 17 18  1  0
 17 19  2  0
 19  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28230

> <plate>
Kinase v5-1

> <well>
N09

> <supplier_cmpd_name>
555551

> <ctcr_id>
2949

> <supplier_cmpd_id>
EMD 555551

> <smiles>
Clc1cc(Cl)c(NC(=O)Nc2ccncc2)c(Cl)c1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{97627-27-5,97627275,"97627 27 5","Rho Kinase Inhibitor II","1-pyridin-4-yl-3-(2,4,6-trichlorophenyl)urea","1pyridin4yl3(2,4,6trichlorophenyl)urea","1 pyridin 4 yl 3 (2,4,6 trichlorophenyl)urea","N-(4
-PYRIDYL)-N'-(2,4,6-TRICHLOROPHENYL)UREA","N(4PYRIDYL)N'(2,4,6TRICHLOROPHENYL)UREA",N(4PYR,"EMD 555551",555551}

> <pdid>

> <targets>
{"Rho Kinase Inhibitor II"}

> <classes>
{}

> <pubchem_cids>
{16760634}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8934   -5.2570    0.0000 C   0  0
    5.1924   -6.0070    0.0000 C   0  0
    6.4915   -5.2571    0.0000 C   0  0
    6.4915   -3.7571    0.0000 C   0  0
    5.1925   -3.0070    0.0000 C   0  0
    7.7911   -6.0075    0.0000 C   0  0
    7.9313   -7.4881    0.0000 C   0  0
    9.3990   -7.7977    0.0000 N   0  0
   10.1470   -6.4975    0.0000 N   0  0
    9.1416   -5.3843    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 10  1  0
  2 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28231

> <plate>
Kinase v5-1

> <well>
N11

> <supplier_cmpd_name>
555555

> <ctcr_id>
6728

> <supplier_cmpd_id>
EMD 555555

> <smiles>
O=C(Nc1ccc(cc1)c2c[nH]nc2)C3COc4ccccc4O3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{CHEMBL519123,1072906-02-5,1072906025,"1072906 02 5","N-(4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide","N(4(1Hpyrazol4yl)phenyl)2,3dihydro1,4benzodioxine2carboxamide","N (4 (1
H pyrazol 4 yl)phenyl) 2","3 dihydro 1","4 benzodioxi","EMD 555555",555555}

> <pdid>

> <targets>
{"Rho Kinase Inhibitor V"}

> <classes>
{}

> <pubchem_cids>
{25093233}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  1  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 C   0  0
    0.0079    7.5003    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  3  2  1  1
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
  9 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 21 25  1  0
 25 18  1  0
 25 26  2  0
 26  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28232

> <plate>
Kinase v5-1

> <well>
N13

> <supplier_cmpd_name>
557360

> <ctcr_id>
1691

> <supplier_cmpd_id>
EMD 557360

> <smiles>
CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1

> <pd_targets>
{LMNA,CCNE1,CDK2,CCNH,CDK7,MNAT1,CCNB1,CDK1,CCNA1,CCNA2,MAPK1,DYRK1B,GMNN,CLK1,DYRK1A,CDK5,CDK5R1,GSK3-BETA,GSK3A,CCNT1,CDK9,RPS6KA2,CSNK1G2,CCND1,CDK4,CCNE2,MAPK3,CSNK1D,CSNK1A1,CDK6,CDK16,CLK2,CSNK1
E,GSK3B,SMN1,CLK4,CCNB2,CCNB3,CSNK1G3,DYRK2,CSNK1G1,SYN1,THRB,PMP22,PAK4,ALK,TTK,CACNA1C,CACNA1B,SRPK1,HIPK4,CYP2D6,CYP1A2,NFKB1,HIF1A,CHRM1,CYP3A4,CYP2C9,TSHR}

> <pathway_gtopdb>
{"Other nuclear protein",Enzyme,"Unclassified protein","Epigenetic regulator","Other cytosolic protein","Transcription factor","Ion channel",Kinase,Reader,"Nuclear receptor","Voltage-gated ion channel
","Protein Kinase","Methyl-lysine/arginine binding protein","Nuclear hormone receptor subfamily 1","Voltage-gated calcium channel","CMGC protein kinase group","AGC protein kinase group","CK1 protein k
inase group","Tudor domain","Nuclear hormone receptor subfamily 1 group A","STE protein kinase group","TKL protein kinase group","Other protein kinase group","CMGC protein kinase CDK family","CMGC pro
tein kinase MAPK family","CMGC protein kinase DYRK family","CMGC protein kinase CLK family","CMGC protein kinase GSK family","AGC protein kinase RSK family","CK1 protein kinase CK1 family","Nuclear ho
rmone receptor subfamily 1 group A member 2","STE protein kinase STE20 family","TKL protein kinase STKR family","Other protein kinase TTK family","CMGC protein kinase CDC2 subfamily","CMGC protein kin
ase CDK7 subfamily","CMGC protein kinase ERK1","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK9 subfamily","AGC protein kinase RSK subfamily","CMGC 
protein kinase TAIRE subfamily","CK1 protein kinase CK1-g","CMGC protein kinase Dyrk2 subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase SRP
K family","CMGC protein kinase HIPK subfamily","Membrane receptor","Cytochrome P450","Family A G protein-coupled receptor","Cytochrome P450 family 2","Cytochrome P450 family 1","Small molecule recepto
r (family A GPCR)","Cytochrome P450 family 3","Peptide receptor (family A GPCR)","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Monoamine receptor","Cytochrome P450 family 3A","Cytochrome P4
50 family 2C","Glycohormone receptor","Cytochrome P450 2D6","Cytochrome P450 1A1","Acetylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 2C9"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Catalytic receptors","Voltage-gated ion channels","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing
 PKA",PKG,"PKC families","CK1: Casein kinase 1","1A. Thyroid hormone receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","Voltage-gated calcium channels"
,"Cyclin-dependent kinase (CDK) family","Mitogen-activated protein kinases (MAP kinases)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CLK family","RSK family","Case
in kinase 1 (CK1) family","STE20 family","TK: Tyrosine kinase","Other protein kinases","CDK1 subfamily","ERK subfamily","Dyrk1 subfamily","CDK5 subfamily","RSK subfamily","CDK9 subfamily","TAIRE subfa
mily","CDK4 subfamily","Dyrk2 subfamily","CDK7 subfamily","PAKB subfamily","Receptor tyrosine kinases (RTKs)","TTK family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","SRPK family
","HIPK subfamily","Cytochrome P450","G protein-coupled receptors","CYP2 family: drug metabolising subset","CYP1 family","Acetylcholine receptors (muscarinic)","CYP3 family","Glycoprotein hormone rece
ptors"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)","Immune System",Metabolism,Disease,"Metabolism of RNA","Neuronal System","Metabolism of proteins","Developmental Biology",Mitotic,"RNA Polymerase II Tra
nscription","Innate Immune System","Metabolism of lipids","Infectious disease","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of non-coding RNA","Transm
ission across Chemical Synapses","Post-translational protein modification","Nervous system development","M Phase","Generic Transcription Pathway","Toll-like Receptor Cascades","Mitotic G1 phase and G1
/S transition","Sphingolipid metabolism","HIV Infection","Mitotic G2-G2/M phases","Signaling by WNT in cancer","snRNP Assembly","Regulation of mitotic cell cycle","Neurotransmitter release cycle",SUMO
ylation,"EGR2 and SOX10-mediated initiation of Schwann cell myelination","Axon guidance","Presynaptic depolarization and calcium channel opening","Mitotic Metaphase and Anaphase","Transcriptional Regu
lation by TP53","Toll Like Receptor 5 (TLR5) Cascade","G1/S Transition","G0 and Early G1","Sphingolipid de novo biosynthesis","HIV Life Cycle","G2/M Transition","Signaling by AMER1 mutants","APC/C-med
iated degradation of cell cycle proteins","G1 Phase","Dopamine Neurotransmitter Release Cycle","SUMO E3 ligases SUMOylate target proteins","Signaling by ROBO receptors","NCAM signaling for neurite out
-growth","Mitotic Anaphase","Regulation of TP53 Activity","MyD88 cascade initiated on plasma membrane","Activation of the pre-replicative complex","Late Phase of HIV Life Cycle","Centrosome maturation
","Truncations of AMER1 destabilize the destruction complex","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Cyclin D associated events in G1","SUMOylation of intracell
ular receptors","Activation of RAC1","NCAM1 interactions","Nuclear Envelope (NE) Reassembly","Regulation of TP53 Expression and Degradation","MAP kinase activation","Regulation of TP53 Activity throug
h Phosphorylation","Transcription of the HIV genome","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic proteins","Ini
tiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","HIV Transcription Elongation","Loss of Nlp from mitotic centrosom
es","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","CREB phosphorylation","Tat-mediated elongation of the HIV-1 transcript
","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated","Formation of HIV-1 elongation complex containing HIV-1 Tat","Cellular responses to external stimuli","Signal Transducti
on","Biological oxidations","Cytokine Signaling in Immune system","Cellular responses to stress","Signaling by GPCR","Phase I - Functionalization of compounds","Signaling by Interleukins","Cellular re
sponse to hypoxia","GPCR ligand binding","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","Cytochrome P450 - arranged by substrate type","Interleukin-1 family signali
ng","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Leishmania parasite growth and survival",Xenob
iotics,"Interleukin-1 signaling","Amine ligand-binding receptors","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","CYP2E1 reactions","Aromatic amines ca
n be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammator
y cytokines production"}

> <broad_targets>
{CDK2,CDK9}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{roscovitine,Seliciclib,186692-46-6,186692466,R-Roscovitine,RRoscovitine,(R)-roscovitine,(R)roscovitine,CYC202,CYC-202,"CYC 202","Roscovitine (Seliciclib,CYC202)",2-(R)-(1-Ethyl-2-hydroxyethylamino)-6
-benzylamino-9-isopropylpurine,2(R)(1Ethyl2hydroxyethylamino)6benzylamino9isopropylpurine,UNII-0ES1C2KQ94,UNII0ES1C2KQ94,(R)-2-((6-(Benzylamino)-9-isopropyl,(R)2((6(Benzylamino)9isopropyl,T2095,S1153,
CC-205,"EMD 557360",Roscovitine,Roscovitine(CYC202),557360,ROSCOVITINE}

> <pdid>
PD011113

> <targets>
{CDK,cdk5,cdc2,cdk2}

> <classes>
{}

> <pubchem_cids>
{160355}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 C   0  0
    0.0079    7.5003    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
  9 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 21 25  1  0
 25 18  1  0
 25 26  2  0
 26  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28233

> <plate>
Kinase v5-1

> <well>
N15

> <supplier_cmpd_name>
557362

> <ctcr_id>
2379

> <supplier_cmpd_id>
EMD 557362

> <smiles>
CCC(CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1

> <pd_targets>
{LMNA,CCNE1,CDK2,CCNH,CDK7,MNAT1,CCNB1,CDK1,CCNA1,CCNA2,MAPK1,DYRK1B,GMNN,CLK1,DYRK1A,CDK5,CDK5R1,GSK3-BETA,GSK3A,CCNT1,CDK9,RPS6KA2,CSNK1G2,CCND1,CDK4,CCNE2,MAPK3,CSNK1D,CSNK1A1,CDK6,CDK16,CLK2,CSNK1
E,GSK3B,SMN1,CLK4,CCNB2,CCNB3,CSNK1G3,DYRK2,CSNK1G1,SYN1,THRB,PMP22,PAK4,ALK,TTK,CACNA1C,CACNA1B,SRPK1,HIPK4,CYP2D6,CYP1A2,NFKB1,HIF1A,CHRM1,CYP3A4,CYP2C9,TSHR}

> <pathway_gtopdb>
{"Other nuclear protein",Enzyme,"Unclassified protein","Epigenetic regulator","Other cytosolic protein","Transcription factor","Ion channel",Kinase,Reader,"Nuclear receptor","Voltage-gated ion channel
","Protein Kinase","Methyl-lysine/arginine binding protein","Nuclear hormone receptor subfamily 1","Voltage-gated calcium channel","CMGC protein kinase group","AGC protein kinase group","CK1 protein k
inase group","Tudor domain","Nuclear hormone receptor subfamily 1 group A","STE protein kinase group","TKL protein kinase group","Other protein kinase group","CMGC protein kinase CDK family","CMGC pro
tein kinase MAPK family","CMGC protein kinase DYRK family","CMGC protein kinase CLK family","CMGC protein kinase GSK family","AGC protein kinase RSK family","CK1 protein kinase CK1 family","Nuclear ho
rmone receptor subfamily 1 group A member 2","STE protein kinase STE20 family","TKL protein kinase STKR family","Other protein kinase TTK family","CMGC protein kinase CDC2 subfamily","CMGC protein kin
ase CDK7 subfamily","CMGC protein kinase ERK1","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK9 subfamily","AGC protein kinase RSK subfamily","CMGC 
protein kinase TAIRE subfamily","CK1 protein kinase CK1-g","CMGC protein kinase Dyrk2 subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase SRP
K family","CMGC protein kinase HIPK subfamily","Membrane receptor","Cytochrome P450","Family A G protein-coupled receptor","Cytochrome P450 family 2","Cytochrome P450 family 1","Small molecule recepto
r (family A GPCR)","Cytochrome P450 family 3","Peptide receptor (family A GPCR)","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Monoamine receptor","Cytochrome P450 family 3A","Cytochrome P4
50 family 2C","Glycohormone receptor","Cytochrome P450 2D6","Cytochrome P450 1A1","Acetylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 2C9"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Catalytic receptors","Voltage-gated ion channels","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing
 PKA",PKG,"PKC families","CK1: Casein kinase 1","1A. Thyroid hormone receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","Voltage-gated calcium channels"
,"Cyclin-dependent kinase (CDK) family","Mitogen-activated protein kinases (MAP kinases)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CLK family","RSK family","Case
in kinase 1 (CK1) family","STE20 family","TK: Tyrosine kinase","Other protein kinases","CDK1 subfamily","ERK subfamily","Dyrk1 subfamily","CDK5 subfamily","RSK subfamily","CDK9 subfamily","TAIRE subfa
mily","CDK4 subfamily","Dyrk2 subfamily","CDK7 subfamily","PAKB subfamily","Receptor tyrosine kinases (RTKs)","TTK family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","SRPK family
","HIPK subfamily","Cytochrome P450","G protein-coupled receptors","CYP2 family: drug metabolising subset","CYP1 family","Acetylcholine receptors (muscarinic)","CYP3 family","Glycoprotein hormone rece
ptors"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)","Immune System",Metabolism,Disease,"Metabolism of RNA","Neuronal System","Metabolism of proteins","Developmental Biology",Mitotic,"RNA Polymerase II Tra
nscription","Innate Immune System","Metabolism of lipids","Infectious disease","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of non-coding RNA","Transm
ission across Chemical Synapses","Post-translational protein modification","Nervous system development","M Phase","Generic Transcription Pathway","Toll-like Receptor Cascades","Mitotic G1 phase and G1
/S transition","Sphingolipid metabolism","HIV Infection","Mitotic G2-G2/M phases","Signaling by WNT in cancer","snRNP Assembly","Regulation of mitotic cell cycle","Neurotransmitter release cycle",SUMO
ylation,"EGR2 and SOX10-mediated initiation of Schwann cell myelination","Axon guidance","Presynaptic depolarization and calcium channel opening","Mitotic Metaphase and Anaphase","Transcriptional Regu
lation by TP53","Toll Like Receptor 5 (TLR5) Cascade","G1/S Transition","G0 and Early G1","Sphingolipid de novo biosynthesis","HIV Life Cycle","G2/M Transition","Signaling by AMER1 mutants","APC/C-med
iated degradation of cell cycle proteins","G1 Phase","Dopamine Neurotransmitter Release Cycle","SUMO E3 ligases SUMOylate target proteins","Signaling by ROBO receptors","NCAM signaling for neurite out
-growth","Mitotic Anaphase","Regulation of TP53 Activity","MyD88 cascade initiated on plasma membrane","Activation of the pre-replicative complex","Late Phase of HIV Life Cycle","Centrosome maturation
","Truncations of AMER1 destabilize the destruction complex","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Cyclin D associated events in G1","SUMOylation of intracell
ular receptors","Activation of RAC1","NCAM1 interactions","Nuclear Envelope (NE) Reassembly","Regulation of TP53 Expression and Degradation","MAP kinase activation","Regulation of TP53 Activity throug
h Phosphorylation","Transcription of the HIV genome","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic proteins","Ini
tiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","HIV Transcription Elongation","Loss of Nlp from mitotic centrosom
es","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","CREB phosphorylation","Tat-mediated elongation of the HIV-1 transcript
","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated","Formation of HIV-1 elongation complex containing HIV-1 Tat","Cellular responses to external stimuli","Signal Transducti
on","Biological oxidations","Cytokine Signaling in Immune system","Cellular responses to stress","Signaling by GPCR","Phase I - Functionalization of compounds","Signaling by Interleukins","Cellular re
sponse to hypoxia","GPCR ligand binding","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","Cytochrome P450 - arranged by substrate type","Interleukin-1 family signali
ng","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Leishmania parasite growth and survival",Xenob
iotics,"Interleukin-1 signaling","Amine ligand-binding receptors","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","CYP2E1 reactions","Aromatic amines ca
n be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammator
y cytokines production"}

> <broad_targets>
{CDK2,CDK9}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{186692-44-4,186692444,Roscovitin,(+/-)-seliciclib,(+/)seliciclib,"Roscovitine, (S)-Isomer","Roscovitine, (S)Isomer",CHEMBL52387,2-((6-(benzylamino)-9-propan-2-ylpurin-2-yl)amino)butan-1-ol,2((6(benzy
lamino)9propan2ylpurin2yl)amino)butan1ol,186692-45-5,186692455,"Seliciclib, (+/-)-","Seliciclib, (+/)","Seliciclib, (RS)-","Seliciclib, (RS)","Seliciclib (+/-)-form (MI)","Seliciclib (+/)form (MI)","(
R,S)-Roscovitine","(R,S)Roscovitine",(+/-)-R,(+/)R,S1153,CC-205,"EMD 557362","EMD 557360",Roscovitine(CYC202),Roscovitine,557362,557360}

> <pdid>
PD011113

> <targets>
{CDK,(S)-Isomer,Roscovitine}

> <classes>
{}

> <pubchem_cids>
{5097}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 41  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.2559   -4.6520    0.0000 C   0  0
    5.8646   -6.1001    0.0000 N   0  0
    6.8071   -7.2647    0.0000 C   0  0
    8.2897   -7.0313    0.0000 C   0  0
    9.2338   -8.1979    0.0000 C   0  0
   10.7164   -7.9645    0.0000 S   0  0
   11.6605   -9.1312    0.0000 C   0  0
   11.1221  -10.5312    0.0000 N   0  0
   13.1423   -8.8979    0.0000 N   0  0
    4.3672   -6.1750    0.0000 C   0  0
    3.4207   -7.3387    0.0000 C   0  0
    1.9397   -7.1008    0.0000 C   0  0
    1.4052   -5.6993    0.0000 C   0  0
    2.3517   -4.5356    0.0000 C   0  0
    3.8327   -4.7735    0.0000 C   0  0
   16.9431   -3.0160    0.0000 C   0  0
   16.9431   -4.5160    0.0000 S   0  0
   16.9431   -6.0160    0.0000 O   0  0
   15.6438   -5.2655    0.0000 O   0  0
   18.2424   -5.2655    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10  5  1  0
  4 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 12 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 25 27  2  0
 20 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 18  1  0
 33 28  1  0
 34 35  1  0
 35 36  1  0
 35 37  2  0
 35 38  2  0
M  END
> <name>
UTKinase_V5

> <id>
28234

> <plate>
Kinase v5-1

> <well>
N17

> <supplier_cmpd_name>
557520

> <ctcr_id>
2798

> <supplier_cmpd_id>
EMD 557520

> <smiles>
Cn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4cn(CCCSC(N)=N)c5ccccc45.C[S](O)(=O)=O

> <pd_targets>
{PRKCA,HST2,HIPK1,TP53,SIRT1,SIRT2,RPS6KB1,PIM1,PRKCB,TBK1,RPS6KA3,GSK3B,MAPT,FTL,RPS6KA2,KMT2A,MEN1,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,MDH,SIRT3,RORC,ALD,PRKACA,CTRB1,FFP,MAP4K1,VR
K2,MAP3K8,VRK1,MAPK1,RECQL,HSD17B10,CYP3A4,TSHR,ALOX15,LEF,RPS6KA5}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator","Other cytosolic protein","Unclassified protein","Membrane receptor",Kinase,Eraser,Reader,Oxidoreductase,"Nuclear receptor",Transferase,Protease,"
Cytochrome P450","Family A G protein-coupled receptor","Protein Kinase","Histone deacetylase",Bromodomain,"Nuclear hormone receptor subfamily 1","Serine protease","Cysteine protease","Cytochrome P450 
family 3","Peptide receptor (family A GPCR)","Metallo protease","AGC protein kinase group","CMGC protein kinase group","HDAC class III","CAMK protein kinase group","Other protein kinase group","Nuclea
r hormone receptor subfamily 1 group F","STE protein kinase group","CK1 protein kinase group","Serine protease PA clan","Cysteine protease CA clan","Cytochrome P450 family 3A","Glycohormone receptor",
"Metallo protease MAE clan","AGC protein kinase PKC family","CMGC protein kinase DYRK family","AGC protein kinase RSK family","CAMK protein kinase PIM family","Other protein kinase IKK family","CMGC p
rotein kinase GSK family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKA family","STE protein kinase STE20 family","STE protein kinase STE11 family","CK1 protein kinas
e VRK family","Serine protease S1A subfamily","CMGC protein kinase MAPK family","Cysteine protease C1A family","Cytochrome P450 3A4","Metallo protease M34 family","AGC protein kinase PKC alpha subfami
ly","CMGC protein kinase HIPK subfamily","AGC protein kinase p70 subfamily","AGC protein kinase RSK subfamily","STE protein kinase KHS subfamily","CMGC protein kinase ERK1","AGC protein kinase MSK sub
family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Catalytic receptors","Nuclear hormone receptors","Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","AGC: Co
ntaining PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","3.5.1.- Histone deacetylases (HDACs)","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","1F. Ret
inoic acid-related orphans","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","CYP3 family","Glycoprotein hormone receptors",Lipoxygenases,"Protein kinase C (
PKC) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","RSK family","PIM family","Other protein kinases","Glycogen synthase kinase (GSK) family","Protein kinase A 
(PKA) family","STE20 family","Vaccina related kinase (VRK) family","STE-unique family","Mitogen-activated protein kinases (MAP kinases)","Delta subfamily","HIPK subfamily","p70 subfamily","Alpha subfa
mily","IKK family","RSK subfamily","GSK subfamily","KHS subfamily","ERK subfamily","MSK subfamily"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Cell Cycle",Disease,"Immune System","Neuronal System","Vesicle-mediated transport",Metabolism,"Signaling by GPCR","RNA Polymerase II Transcrip
tion","Cell Cycle Checkpoints",Mitotic,"MTOR signalling","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System","Infectious disease","Transmission ac
ross Chemical Synapses","Membrane Trafficking","Cytokine Signaling in Immune system","Metabolism of vitamins and cofactors","Metabolism of amino acids and derivatives","Metabolism of lipids","GPCR dow
nstream signalling","Generic Transcription Pathway","G1/S DNA Damage Checkpoints","M Phase","mTORC1-mediated signalling","FLT3 signaling in disease","Toll-like Receptor Cascades","SARS-CoV Infections"
,"Neurotransmitter receptors and postsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","Signaling by Interleukins","Metabolism of water-soluble vitamins and 
cofactors","Branched-chain amino acid catabolism","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","Uptake and actions of bacterial toxins","G alpha (i) signalling ev
ents","Transcriptional Regulation by TP53","p53-Dependent G1/S DNA damage checkpoint","FOXO-mediated transcription","Mitotic Metaphase and Anaphase","Signaling by FLT3 ITD and TKD mutants","Mitotic Pr
ophase","Toll Like Receptor 4 (TLR4) Cascade","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-1 Infection","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis",
"Transcriptional regulation by RUNX3","G2/M Transition","Interleukin-1 family signaling","Cobalamin (Cbl","vitamin B12) transport and metabolism","Biosynthesis of DHA-derived SPMs","Leishmania parasit
e growth and survival","Biosynthesis of DPA-derived SPMs","Uptake and function of anthrax toxins","Visual phototransduction","Regulation of TP53 Activity","p53-Dependent G1 DNA Damage Response","Regul
ation of FOXO transcriptional activity by acetylation","Mitotic Anaphase","STAT5 activation downstream of FLT3 ITD mutants","Nuclear Envelope Breakdown","MyD88-independent TLR4 cascade","MyD88 cascade
 initiated on plasma membrane","SARS-CoV-1 Genome Replication and Transcription","Post NMDA receptor activation events","FOXO-mediated transcription of oxidative stress","metabolic and neuronal genes"
,"RUNX3 Regulates Immune Response and Cell Migration","Centrosome maturation","Interleukin-1 signaling","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection",
"Biosynthesis of DPAn-3 SPMs","The phototransduction cascade","Regulation of TP53 Activity through Phosphorylation","Stabilization of p53","Nuclear Envelope (NE) Reassembly","Depolymerisation of the N
uclear Lamina","TRIF(TICAM1)-mediated TLR4 signaling","MAP kinase activation","Replication of the SARS-CoV-1 genome","Activation of AMPK downstream of NMDARs","Loss of proteins required for interphase
 microtubule organization from the centrosome","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammatory cytokines production","Biosynthesis 
of DPAn-3-derived protectins and resolvins",Inactivation,"recovery and regulation of the phototransduction cascade","Autodegradation of the E3 ubiquitin ligase COP1","Initiation of Nuclear Envelope (N
E) Reformation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","MAPK targets/ Nuclear events mediated by MAP kinases","Loss of Nlp from mitotic centrosomes","CREB phosphorylation","ERK/MAPK ta
rgets","ERKs are inactivated"}

> <broad_targets>
{AKT1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,ROCK1,RPS6KB1,SIRT1}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{"Ro 31-8220 mesylate","Ro 318220 mesylate",138489-18-6,138489186,"Bisindolylmaleimide IX mesylate","Ro 31-8220 (mesylate)","Ro 318220 (mesylate)","RO31-8220 mesylate","RO318220 mesylate","Bisindolylm
aleimide IX, Methanesulfonate",CHEMBL1591531,"InSolution&trade; Ro-31-8220","InSolution&trade; Ro318220",BMK1-D9,BMK1D9,"RO31-8220 methanesulfonate","RO318220 methanesulfonate",Ro?31-8220,Ro?318220,T6
643,"EMD 557520",2002,EI-283,"Ro 31-8220 Mesylate",557520}

> <pdid>
PD038906

> <targets>
{"Broad Spectrum Inhibitor",Ro-31-8220,PKC}

> <classes>
{}

> <pubchem_cids>
{11628205}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 40  0  0  0  0            999 V2000
   -0.0133   -5.9950    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    1.2935   -3.7495    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    2.5987    1.5004    0.0000 C   0  0
    3.8991    0.7525    0.0000 C   0  0
    5.1969    1.5046    0.0000 C   0  0
    5.1945    3.0046    0.0000 C   0  0
    6.4923    3.7567    0.0000 O   0  0
    3.8943    3.7525    0.0000 C   0  0
    2.5964    3.0004    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    5.1932   -3.0130    0.0000 O   0  0
    3.8864   -5.2585    0.0000 C   0  0
    5.1820   -6.0160    0.0000 O   0  0
    5.1746   -7.5168    0.0000 C   0  0
    3.8717   -8.2601    0.0000 C   0  0
    6.4695   -8.2740    0.0000 O   0  0
    2.5847   -6.0040    0.0000 C   0  0
    2.5765   -7.5048    0.0000 O   0  0
    1.2731   -8.2489    0.0000 C   0  0
   -0.0220   -7.4921    0.0000 C   0  0
    1.2648   -9.7488    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  1  0
 14 16  2  0
 16  9  1  0
 16 17  1  0
 17  6  1  0
 17 18  2  0
  7 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
  4 26  1  0
 26 27  1  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 30 32  2  0
 28 33  1  0
 33  2  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 35 37  2  0
M  END
> <name>
UTKinase_V5

> <id>
28235

> <plate>
Kinase v5-1

> <well>
N19

> <supplier_cmpd_name>
559285

> <ctcr_id>
2722

> <supplier_cmpd_id>
EMD 559285

> <smiles>
CC1OC(OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)cc4)C(O)C(OC(C)=O)C1OC(C)=O

> <pd_targets>
{RPS6KA3,CYP3A4,CYP2D6}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 3","Cytochrome P450 family 2","AGC protein kinase group","Cytochrome P450 family 3A","Cytochrome P450 family 2D","AGC protein 
kinase RSK family","Cytochrome P450 3A4","Cytochrome P450 2D6","AGC protein kinase RSK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Cytochrome P450","AGC: Containing PKA",PKG,"PKC families","CYP3 family","CYP2 family: drug metabolising subset","RSK family","RSK subfamily"}

> <pathway_reactome>
{"Immune System",Metabolism,"Innate Immune System","Metabolism of lipids","Biological oxidations","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - F
unctionalization of compounds","Toll Like Receptor 5 (TLR5) Cascade","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","MyD88 cascade initiated on plasma membrane","Bio
synthesis of maresins",Xenobiotics,"MAP kinase activation","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","MAPK targets/ Nuclear events mediated by MAP kinases","CREB phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"SL 0101-1","SL 01011",SL0101,77307-50-7,77307507,"3'',4''-Diacetylafzelin","3'',4''Diacetylafzelin","3'',4''-O-Diacetylafzelin","3'',4''ODiacetylafzelin",CHEMBL3187298,SCHEMBL12693944,HMS3229N19,NSC
703081,AKOS024457006,NSC-703081,NCGC00346893-01,NCGC0034689301,SL-0101-1,SL01011,FT-0674606,FT0674606,"EMD 559285",559285}

> <pdid>
PD015703

> <targets>
{"RSK Inhibitor",SL0101,"Ribosomal S6 Kinase (RSK)"}

> <classes>
{MAPK/ERK Pathway}

> <pubchem_cids>
{14825856}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    2.5983   -3.0004    0.0000 C   0  0
    2.5988   -1.5004    0.0000 S   0  0
    3.8983   -0.7512    0.0000 O   0  0
    3.8975   -2.2510    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 N   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.8193    4.6606    0.0000 C   0  0
   -4.0353    5.9336    0.0000 C   0  0
   -4.7489    7.2530    0.0000 C   0  0
   -6.2483    7.2947    0.0000 N   0  0
   -7.0341    6.0170    0.0000 C   0  0
   -6.3205    4.6976    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -6.4469    1.8311    0.0000 C   0  0
   -7.4153    2.9701    0.0000 C   0  0
   -8.8906    2.6991    0.0000 C   0  0
   -9.3937    1.2860    0.0000 C   0  0
  -10.8690    1.0150    0.0000 F   0  0
   -8.4213    0.1438    0.0000 C   0  0
   -6.9460    0.4147    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  2  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  8 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 13 20  2  0
 20 21  1  0
 21 11  2  0
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28236

> <plate>
Kinase v5-1

> <well>
N21

> <supplier_cmpd_name>
559399

> <ctcr_id>
2807

> <supplier_cmpd_id>
EMD 559399

> <smiles>
C[S](=O)(=O)c1ccc(cc1)c2[nH]c(c3ccncc3)c(n2)c4ccc(F)cc4

> <pd_targets>
{ALOX5,ALDH1A1,MAPK14,SMN1}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Oxidoreductase,Kinase,Reader,"Protein Kinase","Methyl-lysine/arginine binding protein","CMGC protein kinase group","Tudor domain","CMGC protein kinase MAPK family","CMGC
 protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Eicosanoid turnover","Kinases (EC 2.7.x.x)",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{Metabolism,"Immune System","Metabolism of RNA","Metabolism of lipids","Biological oxidations","Innate Immune System","Metabolism of non-coding RNA","Biosynthesis of specialized proresolving mediators
 (SPMs)","Phase I - Functionalization of compounds","Toll-like Receptor Cascades","snRNP Assembly","Biosynthesis of DPA-derived SPMs","Ethanol oxidation","Toll Like Receptor 5 (TLR5) Cascade","Biosynt
hesis of DPAn-3 SPMs","MyD88 cascade initiated on plasma membrane","Biosynthesis of DPAn-3-derived 13-series resolvins","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","
Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{152121-46-5,152121465,CAY10571,"SB 203580, Sulfone",4-(4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl)pyridine,4(4(4fluorophenyl)2(4methylsulfonylphenyl)1Himidazol5yl)pyridine,"SB 203
580 Sulfone",CHEMBL280317,4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole,4(4Fluorophenyl)2(4methylsulfonylphenyl)5(4pyridyl)1Himidazole,Bio2_000392,Bio2000392,Bio2-000392,"Bi
o2 000392",BiomolKI_0000,BiomolKI0000,BiomolKI-0000,"BiomolKI 0000","EMD 559399",559399}

> <pdid>
PD044393

> <targets>
{"SB 203580",Sulfone}

> <classes>
{}

> <pubchem_cids>
{6610350}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.9511   -0.8815    0.0000 N   0  0
   -4.9530   -1.9978    0.0000 C   0  0
   -4.2010   -3.2957    0.0000 N   0  0
   -2.7343   -2.9815    0.0000 C   0  0
   -1.6115   -3.9772    0.0000 C   0  0
   -0.1605   -3.6178    0.0000 C   0  0
    0.8791   -4.6991    0.0000 C   0  0
    0.4626   -6.1401    0.0000 C   0  0
    1.5022   -7.2213    0.0000 F   0  0
   -0.9936   -6.4998    0.0000 C   0  0
   -2.0333   -5.4186    0.0000 C   0  0
   -4.2568    0.5878    0.0000 C   0  0
   -3.2235    1.6679    0.0000 C   0  0
   -3.6446    3.1076    0.0000 C   0  0
   -5.1020    3.4627    0.0000 C   0  0
   -5.5231    4.9024    0.0000 O   0  0
   -6.1382    2.3782    0.0000 C   0  0
   -5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  9  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 14  1  0
 10 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 26 27  1  0
 27 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28237

> <plate>
Kinase v5-1

> <well>
P03

> <supplier_cmpd_name>
559404

> <ctcr_id>
4949

> <supplier_cmpd_id>
EMD 559404

> <smiles>
COc1nccc(n1)c2n(cnc2c3ccc(F)cc3)C4CCC(O)CC4

> <pd_targets>
{MAPK14,LCK,MAPK11,PRKCA,MAPK9,EGFR,RAF1,CYP2D6,CYP2C9,CSNK1D,MINK1,KDM4E,MAP4K4,PRKD2,CSNK1A1,CYP2C19,CYP1A2,PRKD3,MAP4K5,RORC,FRK}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Transcription factor",Kinase,"Cytochrome P450",Eraser,"Nuclear receptor","Protein Kinase","Cytochrome P450 family 2","Lysine demethylase","Cytochrome P450 family 1","Nu
clear hormone receptor subfamily 1","CMGC protein kinase group","TK protein kinase group","AGC protein kinase group","TKL protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 2C",
"CK1 protein kinase group","STE protein kinase group","Jumonji domain-containing","CAMK protein kinase group","Cytochrome P450 family 1A","Nuclear hormone receptor subfamily 1 group F","CMGC protein k
inase MAPK family","Tyrosine protein kinase Src family","AGC protein kinase PKC family","Tyrosine protein kinase EGFR family","TKL protein kinase RAF family","Cytochrome P450 2D6","Cytochrome P450 2C9
","CK1 protein kinase CK1 family","STE protein kinase STE20 family","CAMK protein kinase PKD family","Cytochrome P450 2C19","Cytochrome P450 1A1","Nuclear hormone receptor subfamily 1 group F member 3
","CMGC protein kinase p38 subfamily","AGC protein kinase PKC alpha subfamily","CMGC protein kinase JNK subfamily","STE protein kinase MSN subfamily","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Cytochrome P450","Chromatin modifying enzymes","Nuclear hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor ki
nases","AGC: Containing PKA",PKG,"PKC families","CYP2 family: drug metabolising subset","CK1: Casein kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","1.14.11.- Histone d
emethylases","CAMK: Calcium/calmodulin-dependent protein kinases","CYP1 family","1F. Retinoic acid-related orphans","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","Protein kin
ase C (PKC) family","TKL: Tyrosine kinase-like","Casein kinase 1 (CK1) family","STE20 family","Protein kinase D (PKD) family","p38 subfamily","Non-receptor tyrosine kinases (nRTKs)","Delta subfamily",
"JNK subfamily","Receptor tyrosine kinases (RTKs)","RAF family","MSN subfamily","KHS subfamily","Src family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Immune System",Disease,"Signal Transduction",Metabolism,"Cell Cycle","Cellular responses to external stimuli","Gene expression (Transcription)","Innate Immune System","Infectious disease","Signaling
 by GPCR","MAPK family signaling cascades","Biological oxidations",Mitotic,"Cellular responses to stress","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second 
messengers","RNA Polymerase II Transcription","Intracellular signaling by second messengers","Toll-like Receptor Cascades","HIV Infection","GPCR downstream signalling","MAPK1/MAPK3 signaling","Phase I
 - Functionalization of compounds","Mitotic G2-G2/M phases","Cellular Senescence","Sphingolipid metabolism","Signaling by WNT in cancer","Generic Transcription Pathway","PIP3 activates AKT signaling",
"Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","G alpha (i) signalling events","G alpha (q) signalling events","RAF/MAP kinase cascade","Cytochrome P450 - arranged by substra
te type","G2/M Transition","Oxidative Stress Induced Senescence","Sphingolipid de novo biosynthesis","Signaling by AMER1 mutants","Transcriptional regulation by RUNX3","PTEN Regulation","MyD88 cascade
 initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Visual phototransduction","Gastrin-CREB signalling pathway via PKC and MAPK","Negative regulation of MAP
K pathway",Xenobiotics,"Centrosome maturation","Truncations of AMER1 destabilize the destruction complex","RUNX3 Regulates Immune Response and Cell Migration","Regulation of PTEN stability and activit
y","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","The phototransduction cascade","EGFR Transactivation by Gastrin","Negative 
feedback regulation of MAPK pathway","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","Aromatic amines can be N-hydroxylated or N-dealkylated 
by CYP1A2","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation",Inactivation,"recovery and regulation of the phototransduction cascade","Loss of Nlp from mitotic c
entrosomes","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK11,MAPK14,PTGS2}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"SB 239063",193551-21-2,193551212,SB239063,SB-239063,UNII-HII3DC8CPI,UNIIHII3DC8CPI,CHEMBL97162,HII3DC8CPI,CHEMBL4166018,CHEBI:90681,MFCD03792786,Kinome_3168,Kinome3168,Kinome-3168,"Kinome 3168",Tocr
is-1962,Tocris1962,cc-465,cc465,MLS006010690,SCHEMBL173595,SCHEMBL173596,CHEMBL256835,SCHEMBL4918359,SCHEMBL13933075,CHEBI:91347,"EMD 559404",1962,559404}

> <pdid>
PD013030

> <targets>
{"p38 MAPK","SB 239063"}

> <classes>
{}

> <pubchem_cids>
{5166}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 49  0  0  0  0            999 V2000
    7.6253   -9.1317    0.0000 O   0  0
    6.4092   -8.2536    0.0000 C   0  0
    5.0407   -8.8678    0.0000 C   0  0
    3.8245   -7.9897    0.0000 C   0  0
    3.9768   -6.4974    0.0000 C   0  0
    5.3454   -5.8833    0.0000 C   0  0
    6.5615   -6.7614    0.0000 C   0  0
    2.7618   -5.6164    0.0000 C   0  0
    2.9160   -4.1261    0.0000 C   0  0
    1.7981   -3.1260    0.0000 C   0  0
    0.3319   -3.4425    0.0000 O   0  0
    2.4039   -1.7537    0.0000 C   0  0
    3.8941   -1.9062    0.0000 C   0  0
    5.1902   -1.1527    0.0000 C   0  0
    5.4974    0.3155    0.0000 C   0  0
    6.9225    0.7835    0.0000 C   0  0
    8.0404   -0.2167    0.0000 C   0  0
    7.7332   -1.6849    0.0000 C   0  0
    6.3081   -2.1529    0.0000 C   0  0
    5.7029   -3.5245    0.0000 N   0  0
    4.2106   -3.3725    0.0000 C   0  0
    1.6497   -0.4563    0.0000 C   0  0
    0.1899   -0.2090    0.0000 C   0  0
   -1.1611   -0.8589    0.0000 C   0  0
   -1.5821   -2.2986    0.0000 C   0  0
   -3.0395   -2.6538    0.0000 C   0  0
   -4.0758   -1.5693    0.0000 C   0  0
   -3.6548   -0.1296    0.0000 C   0  0
   -2.1974    0.2256    0.0000 C   0  0
   -1.4869    1.5457    0.0000 N   0  0
   -0.0111    1.2775    0.0000 C   0  0
    1.3384    1.9277    0.0000 C   0  0
    1.6087    3.4014    0.0000 C   0  0
    0.4662    4.3747    0.0000 C   0  0
    0.7346    5.8505    0.0000 C   0  0
   -0.4092    6.8209    0.0000 C   0  0
   -1.8215    6.3155    0.0000 C   0  0
   -2.9653    7.2859    0.0000 O   0  0
   -2.0900    4.8398    0.0000 C   0  0
   -0.9462    3.8694    0.0000 C   0  0
    2.3748    0.8433    0.0000 C   0  0
    3.8627    1.0331    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  2  3
 21  9  1  0
 21 13  1  0
 12 22  1  0
 22 23  2  3
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 29 30  1  0
 30 31  2  3
 31 23  1  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 38  1  0
 37 39  1  0
 39 40  2  0
 40 34  1  0
 32 41  1  0
 41 22  1  0
 41 42  2  0
M  END
> <name>
UTKinase_V5

> <id>
28238

> <plate>
Kinase v5-1

> <well>
P05

> <supplier_cmpd_name>
565715

> <ctcr_id>
7719

> <supplier_cmpd_id>
EMD 565715

> <smiles>
Oc1ccc(cc1)\C=C2\C(=O)C(=C3c4ccccc4N=C23)C5=C6c7ccccc7N=C6C(=C\c8ccc(O)cc8)/C5=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Scytonemin,CHEMBL507146,CHEBI:90127,152075-98-4,152075984,SCHEMBL306255,HMS3229P05,BDBM50263696,ZINC35212833,K00271,"EMD 565715",565715}

> <pdid>

> <targets>
{Scytonemin,"Lyngbya sp."}

> <classes>
{}

> <pubchem_cids>
{135473381}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 C   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 C   0  0
    3.8975   -2.2510    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 N   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -3.9027    5.2517    0.0000 C   0  0
   -5.2032    5.9990    0.0000 C   0  0
   -6.5007    5.2464    0.0000 C   0  0
   -6.4977    3.7464    0.0000 C   0  0
   -5.1971    2.9990    0.0000 C   0  0
   -7.8019    5.9941    0.0000 N   0  0
   -7.9452    7.4744    0.0000 C   0  0
   -9.4135    7.7810    0.0000 C   0  0
  -10.1588    6.4792    0.0000 N   0  0
   -9.1511    5.3682    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  8 11  1  0
 11 12  2  0
 11 13  2  0
 11 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 18 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28239

> <plate>
Kinase v5-1

> <well>
P07

> <supplier_cmpd_name>
569615

> <ctcr_id>
4492

> <supplier_cmpd_id>
EMD 569615

> <smiles>
CC(C)(C)c1ccc(cc1)[S](=O)(=O)Nc2ccc(cc2)n3ccnc3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ISCK03,945526-43-2,945526432,ISCK-03,"tert-Butylphenyl imidazolylphenyl sulfonamide","tertButylphenyl imidazolylphenyl sulfonamide",UNII-3028H7W568,UNII3028H7W568,4-tert-butyl-N-(4-imidazol-1-ylpheny
l)benzenesulfonamide,4tertbutylN(4imidazol1ylphenyl)benzenesulfonamide,3028H7W568,Whiteplex-IN,WhiteplexIN,"Stem-Cell Factor/c-Kit Inhibitor, ISCK03","StemCell Factor/cKit Inhibitor, ISCK03","ISCK 03"
,"t-Butylphenyl imidazol","tButylphenyl imidazol",T3452,"EMD 569615",569615}

> <pdid>
PD018629

> <targets>
{"Stem-Cell Factor/c-Kit Inhibitor",ISCK03}

> <classes>
{}

> <pubchem_cids>
{3792751}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -5.1930    3.0046    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0875    3.7680    0.0000 Cl  0  0
   -7.7962    1.5135    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -6.5050   -0.7409    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  2  0
 17 11  1  0
 17 18  1  0
  9 19  2  0
 19  5  1  0
 19 20  1  0
 20 21  2  0
 21  3  1  0
 21 22  1  0
 22 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28240

> <plate>
Kinase v5-1

> <well>
P09

> <supplier_cmpd_name>
570100

> <ctcr_id>
2028

> <supplier_cmpd_id>
EMD 570100

> <smiles>
COc1cc2ncnc(Nc3ccc(Cl)cc3Cl)c2cc1OC

> <pd_targets>
{FLT1,EPHB2,KDR,FGFR1,FLT4,EGFR,SRC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Eph family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase EGF
R family","Tyrosine protein kinase Src family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XIII RTKs: 
Ephrin receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Non-receptor tyrosine kinases (nRTKs)","Src family"
}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology",Disease,"Signaling by Receptor Tyrosine Kinases","Nervous system development","Diseases of signal transduction by growth factor receptors and second mess
engers","Signaling by GPCR","Signaling by VEGF","Axon guidance","Signaling by FGFR in disease","GPCR downstream signalling","VEGF ligand-receptor interactions","EPH-Ephrin signaling","VEGFA-VEGFR2 Pat
hway","Signaling by FGFR1 in disease","G alpha (q) signalling events","VEGF binds to VEGFR leading to receptor dimerization","EPHB-mediated forward signaling","VEGFR2 mediated cell proliferation","FGF
R1 mutant receptor activation","Gastrin-CREB signalling pathway via PKC and MAPK","Signaling by activated point mutants of FGFR1","EGFR Transactivation by Gastrin","Signaling by NTRKs","Signaling by N
TRK1 (TRKA)","Signalling to ERKs","Signalling to RAS","p38MAPK events"}

> <broad_targets>
{EGFR,FLT1,FLT4,KDR}

> <broad_moa>
{"Abl kinase inhibitor","SRC inhibitor","VEGFR inhibitor"}

> <synonyms>
{"N-(2,4-dichlorophenyl)-6,7-dimethoxyquinazolin-4-amine","N(2,4dichlorophenyl)6,7dimethoxyquinazolin4amine",331662-51-2,331662512,"Ste11 MAPKKK Activation Inhibitor","quinazoline deriv. 3a",Bionet1_0
03518,Bionet1003518,Bionet1-003518,"Bionet1 003518",Oprea1_210976,Oprea1210976,Oprea1-210976,"Oprea1 210976",BDBM4493,CHEMBL128356,"N-(2,4-dichlorophenyl)-6,7-dimethoxy-4-quinazolinamine","N(2,4dichlo
rophenyl)6,7dimethoxy4quinazolinamine",HMS578L20,T1754,"EMD 570100","ZM 306416",570100}

> <pdid>
PD010526

> <targets>
{VEGFR,"Ste11 MAPKKK Activation Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{1474860}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    7.0425   -2.3851    0.0000 O   0  0
    3.8978   -2.2504    0.0000 N   0  0
    2.5988   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1953   -1.5031    0.0000 N   0  0
   -5.1932   -3.0039    0.0000 C   0  0
   -6.4914   -3.7570    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -7.7904   -6.0071    0.0000 C   0  0
   -9.0895   -5.2571    0.0000 C   0  0
   -9.0895   -3.7571    0.0000 N   0  0
   -7.7905   -3.0071    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 N   0  0
    1.3039   -3.7494    0.0000 C   0  0
    1.2114   -5.2538    0.0000 C   0  0
    2.3145   -6.2703    0.0000 C   0  0
    3.7970   -6.0416    0.0000 C   0  0
    4.5425   -4.7400    0.0000 C   0  0
    3.9897   -3.3456    0.0000 C   0  0
    2.5548   -2.9084    0.0000 C   0  0
  2  3  3  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 10 19  2  0
 19 20  1  0
 20  7  1  0
 20 21  2  0
 21  4  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28241

> <plate>
Kinase v5-1

> <well>
P11

> <supplier_cmpd_name>
616404

> <ctcr_id>
3696

> <supplier_cmpd_id>
EMD 616404

> <smiles>
O.N#Cc1cnc2cnc(NCc3cccnc3)cc2c1NC4CCCCCC4

> <pd_targets>
{SRC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Src family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Src family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by NTRKs","Signaling by NTRK1 (TRKA)","Signalling to ERKs","Signalling to RAS","p38MAPK events"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HMS3229P11,"EMD 616404",616404}

> <pdid>
PD033139

> <targets>
{"Tpl2 Kinase Inhibitor II"}

> <classes>
{}

> <pubchem_cids>
{25181194}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 18  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.4470    5.2297    0.0000 C   0  0
   -0.3298    6.2307    0.0000 O   0  0
   -2.9153    5.5365    0.0000 C   0  0
   -3.6607    4.2349    0.0000 C   0  0
   -2.6532    3.1236    0.0000 C   0  0
   -2.9512    1.6535    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  2  1  0
  8  9  1  0
  4 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  3
 15 16  1  0
 16 11  1  0
 16 17  2  0
M  END
> <name>
UTKinase_V5

> <id>
28242

> <plate>
Kinase v5-1

> <well>
P13

> <supplier_cmpd_name>
655203

> <ctcr_id>
2152

> <supplier_cmpd_id>
EMD 655203

> <smiles>
Cc1cc(cc(C)c1O)C=C2C(=O)C=CC2=O

> <pd_targets>
{SRC,EEF2K}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Atypical protein kinase group","Tyrosine protein kinase Src family","Atypical protein kinase alpha family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases",Atypical,"TK: Tyrosine kinase","Alpha kinase family","Non-receptor tyrosine kinases (nRTKs)","eEF2K subfamily","Src f
amily"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","MTOR signalling","Signaling by NTRKs","mTORC1-mediated signalling","Signaling by NTRK1 (TRKA)","Signalling to ERKs","Signalling to RAS"
,"p38MAPK events"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{TX-1918,TX1918,503473-32-3,503473323,"2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione","2((3,5dimethyl4hydroxyphenyl)methylene)4cyclopentene1,3dione",CHEMBL437612,"2-((4-hydroxy
-3,5-dimethylphenyl)methylidene)cyclopent-4-ene-1,3-dione","2((4hydroxy3,5dimethylphenyl)methylidene)cyclopent4ene1,3dione",K00011,SCHEMBL16971039,HMS3229P13,HMS3674M15,BCP16358,BDBM50375667,ZIN,"EMD 
655203",655203}

> <pdid>
PD038972

> <targets>
{TX-1918}

> <classes>
{}

> <pubchem_cids>
{6419746}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 O   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17 11  1  0
  9 18  2  0
 18  5  1  0
 18 19  1  0
 19 20  2  0
 20  3  1  0
 20 21  1  0
 21 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28243

> <plate>
Kinase v5-1

> <well>
P15

> <supplier_cmpd_name>
681500

> <ctcr_id>
4471

> <supplier_cmpd_id>
EMD 681500

> <smiles>
COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC

> <pd_targets>
{FGFR1,KDR,FLT1,EPHB2,CDK2,TTBK1,RET,PIK3R1,KIF5B}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","CK1 protein kinase group","Tyrosine protein kinase FGFR family","Tyrosine protein kinase VEGFR family","Tyrosine 
protein kinase Eph family","CMGC protein kinase CDK family","Tyrosine protein kinase Ret family","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Glycerophospholipid turnover","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","Phosphatidylin
ositol kinases","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","Tau tubulin kinase (TTBK) family","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","Type V RTKs: FGF (fibroblast growth
 factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XIII RTKs: Ephrin receptor family","Type XIV RTKs: RET"}

> <pathway_reactome>
{Disease,"Signal Transduction","Developmental Biology","Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyros
ine Kinases","Nervous system development","RNA Polymerase II Transcription","Signaling by FGFR in disease","Signaling by VEGF","Axon guidance","Generic Transcription Pathway","Signaling by FGFR1 in di
sease","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","EPH-Ephrin signaling","Transcriptional Regulation by TP53","RET signaling","FGFR1 mutant receptor activation","VEGFR2 mediated cell p
roliferation","VEGF binds to VEGFR leading to receptor dimerization","EPHB-mediated forward signaling","Regulation of TP53 Activity","Signaling by activated point mutants of FGFR1","Regulation of TP53
 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{whi-p180,whip180,211555-08-7,211555087,"3-((6,7-dimethoxyquinazolin-4-yl)amino)phenol","3((6,7dimethoxyquinazolin4yl)amino)phenol","4-(3-HYDROXYANILINO)-6,7-DIMETHOXYQUINAZOLINE","4(3HYDROXYANILINO)6
,7DIMETHOXYQUINAZOLINE","JANEX 3","WHI-P180, Hydrochloride","WHIP180, Hydrochloride","3-((6,7-Dimethoxyquinazolin-4-yl)amino)phenol","3((6,7Dimethoxyquinazolin4yl)amino)phenol",CHEMBL127907,3-(6,3(6,7
-dimethoxyquinazolin-4-ylam,7dimethoxyquinazolin4ylam,T2032,"EMD 681500",WHI-P180,681500}

> <pdid>
PD007048

> <targets>
{WHI-P180,Hydrochloride,EGFR,RET,VEGFR}

> <classes>
{JAK/STAT Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{5687}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    5.0987   -1.7281    0.0000 O   0  0
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 C   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -7.1998   -1.6833    0.0000 C   0  0
   -8.0836   -0.4712    0.0000 C   0  0
   -9.5751   -0.6304    0.0000 C   0  0
  -10.1830   -2.0016    0.0000 C   0  0
   -9.2994   -3.2138    0.0000 C   0  0
   -7.8079   -3.0546    0.0000 C   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -5.1376   -4.2063    0.0000 C   0  0
   -6.5079   -4.8163    0.0000 O   0  0
   -3.8385   -4.9563    0.0000 N   0  0
   -2.7238   -3.9526    0.0000 C   0  0
   -1.2566   -4.2643    0.0000 O   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 10 17  2  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 17  1  0
 23 24  2  0
 24  8  1  0
 24 25  1  0
 25  6  1  0
 25 26  2  0
 26  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28244

> <plate>
Kinase v5-1

> <well>
P17

> <supplier_cmpd_name>
681637

> <ctcr_id>
4214

> <supplier_cmpd_id>
EMD 681637

> <smiles>
O.Oc1ccc2[nH]c3cc(c4ccccc4)c5C(=O)NC(=O)c5c3c2c1

> <pd_targets>
{CHEK1,WEE1,CDK4,FTL,RORC,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,KMT2A,MEN1,FFP,ALD}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Transcription factor","Epigenetic regulator",Kinase,"Nuclear receptor",Reader,Transferase,"Protein Kinase","Nuclear hormone receptor subfamily 1",Bromodomain,"CAMK prot
ein kinase group","Other protein kinase group","CMGC protein kinase group","Nuclear hormone receptor subfamily 1 group F","AGC protein kinase group","CAMK protein kinase CAMK1 family","Other protein k
inase WEE family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKC family","CAMK protein kinase CHK1 subfamily","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Nuclear hormone receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CL
K families","1F. Retinoic acid-related orphans","CAMK-like (CAMKL) family","Other protein kinases","Cyclin-dependent kinase (CDK) family","CHK1 subfamily","WEE family","CDK4 subfamily"}

> <pathway_reactome>
{"DNA Repair","Cell Cycle","Vesicle-mediated transport","Gene expression (Transcription)","DNA Double-Strand Break Repair","Cell Cycle Checkpoints",Mitotic,"Membrane Trafficking","RNA Polymerase II Tr
anscription","Homology Directed Repair","G2/M Checkpoints","Mitotic G1 phase and G1/S transition","trans-Golgi Network Vesicle Budding","Generic Transcription Pathway","HDR through Homologous Recombin
ation (HRR) or Single Strand Annealing (SSA)","G2/M DNA damage checkpoint","G1 Phase","Golgi Associated Vesicle Biogenesis","Transcriptional regulation by RUNX3","HDR through Homologous Recombination 
(HRR)","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cyclin D associated events in G1","RUNX3 Regulates Immune Response and Cell Migration","Homologous DNA Pairing and Strand Excha
nge","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{WEE1}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{"Wee1/Chk1 Inhibitor",HMS3229P17,"4-(2-Phenyl)-9-hydroxypyrrolo(3,4-c)carbazole-1,3-(2H,6H)-dione","4(2Phenyl)9hydroxypyrrolo(3,4c)carbazole1,3(2H,6H)dione","EMD 681637",681637}

> <pdid>
PD005968

> <targets>
{"Checkpoint Kinases","Wee1/Chk1 Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{16760707}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 30  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 C   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -7.1998   -1.6833    0.0000 C   0  0
   -7.8079   -3.0546    0.0000 C   0  0
   -9.2994   -3.2138    0.0000 C   0  0
  -10.1830   -2.0016    0.0000 C   0  0
   -9.5751   -0.6304    0.0000 C   0  0
   -8.0836   -0.4712    0.0000 C   0  0
   -7.4757    0.9001    0.0000 Cl  0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -5.1376   -4.2063    0.0000 C   0  0
   -6.5079   -4.8163    0.0000 O   0  0
   -3.8385   -4.9563    0.0000 N   0  0
   -2.7238   -3.9526    0.0000 C   0  0
   -1.2566   -4.2643    0.0000 O   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 15 16  1  0
  9 17  2  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 17  1  0
 23 24  2  0
 24  7  1  0
 24 25  1  0
 25  5  1  0
 25 26  2  0
 26  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28245

> <plate>
Kinase v5-1

> <well>
P19

> <supplier_cmpd_name>
681640

> <ctcr_id>
1291

> <supplier_cmpd_id>
EMD 681640

> <smiles>
Oc1ccc2[nH]c3cc(c4ccccc4Cl)c5C(=O)NC(=O)c5c3c2c1

> <pd_targets>
{MST1R,PRKCQ,RPS6KA3,WEE1,GSK3B,CDK2,CHEK1,MAP2K2,GSK3A,PAK4,ALK,AURKB,TNK2,DAPK3,MAP4K2,TYRO3,CDK5,ACVR1,STK3,JAK2,LTK,KDR,TAOK1,PKN2,JAK3,HIPK2,PRKACA,LCK,SYK,PRKX,MINK1,CSNK1A1,CAMK2D,MAP4K5,MAP2K1
,DYRK1A,IKBKE,LRRK2,STK17A,ABL1,PIM1,PRKAA1,DYRK1B,CAMK1D,FYN}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","AGC protein kinase group","Other protein kinase group","CMGC protein kinase group","CAMK protein kinase group","STE protein kinase group","TK
L protein kinase group","CK1 protein kinase group","Tyrosine protein kinase Met family","AGC protein kinase PKC family","AGC protein kinase RSK family","Other protein kinase WEE family","CMGC protein 
kinase GSK family","CMGC protein kinase CDK family","CAMK protein kinase CAMK1 family","STE protein kinase STE7 family","STE protein kinase STE20 family","TKL protein kinase STKR family","Other protei
n kinase AUR family","Tyrosine protein kinase Ack family","CAMK protein kinase DAPK family","Tyrosine protein kinase Axl family","Tyrosine protein kinase JakA family","Tyrosine protein kinase Alk fami
ly","Tyrosine protein kinase VEGFR family","AGC protein kinase PKN family","CMGC protein kinase DYRK family","AGC protein kinase PKA family","Tyrosine protein kinase Src family","Tyrosine protein kina
se Syk family","CK1 protein kinase CK1 family","CAMK protein kinase CAMK2 family","TKL protein kinase LRRK family","Tyrosine protein kinase Abl family","CAMK protein kinase PIM family","AGC protein ki
nase PKC delta subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase CDC2 subfamily","CAMK protein kinase CHK1 subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR Type
 1 subfamily","STE protein kinase KHS subfamily","CMGC protein kinase CDK5 subfamily","TKL protein kinase STKR1","STE protein kinase MST subfamily","STE protein kinase TAO subfamily","CMGC protein kin
ase HIPK subfamily","STE protein kinase MSN subfamily","CMGC protein kinase Dyrk1 subfamily","CAMK protein kinase AMPK subfamily","Tyrosine protein kinase SrcA"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-de
pendent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","TK: Tyrosine kinase","Protein kinase C (PKC) family","RSK family","Other protein k
inases","Glycogen synthase kinase (GSK) family","Cyclin-dependent kinase (CDK) family","CAMK-like (CAMKL) family","STE7 family","STE20 family","Death-associated kinase (DAPK) family","TKL: Tyrosine ki
nase-like","Protein kinase N (PKN) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Protein kinase A (PKA) family","Casein kinase 1 (CK1) family","CAMK2 family",
"PIM family","CAMK1 family","Receptor tyrosine kinases (RTKs)","Delta subfamily","RSK subfamily","WEE family","GSK subfamily","CDK1 subfamily","CHK1 subfamily","PAKB subfamily","Aurora kinase (Aur) fa
mily","Non-receptor tyrosine kinases (nRTKs)","KHS subfamily","CDK5 subfamily","Receptor serine/threonine kinase (RSTK) family","MST subfamily","TAO subfamily","HIPK subfamily","MSN subfamily","Dyrk1 
subfamily","IKK family","Leucine-rich repeat kinase (LRRK) family","AMPK subfamily","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) recept
or family","Ack family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type I receptor serine/threonine kinases","Janus kinase (JakA) family","Type IV RTKs: VEGF (vascular endothelial
 growth factor) receptor family","Src family","Syk family","Abl family"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Cell Cycle",Disease,"Gene expression (Transcription)","DNA Repair","Developmental Biology","Programmed Cell Death","Cellular responses to external stimuli","Neu
ronal System","Signaling by Receptor Tyrosine Kinases","Signaling by GPCR","Innate Immune System","Cell Cycle Checkpoints","Infectious disease","RNA Polymerase II Transcription","DNA Double-Strand Bre
ak Repair","Nervous system development",Mitotic,Apoptosis,"Signaling by Hippo","Signaling by Rho GTPases","Cytokine Signaling in Immune system","Cellular responses to stress","Diseases of signal trans
duction by growth factor receptors and second messengers","Transmission across Chemical Synapses","Signaling by Non-Receptor Tyrosine Kinases","Signaling by MST1","GPCR downstream signalling","Toll-li
ke Receptor Cascades","G2/M Checkpoints","SARS-CoV Infections","Generic Transcription Pathway","Homology Directed Repair","Signaling by NTRKs","Axon guidance","M Phase","Caspase activation via extrins
ic apoptotic signalling pathway","Mitotic G1 phase and G1/S transition","Signaling by VEGF","RHO GTPase Effectors","Signaling by Interleukins","Mitotic G2-G2/M phases","HIV Infection","Leishmania infe
ction","Cellular Senescence","Signaling by WNT in cancer","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by PTK6","FLT3 signaling in disease","G alpha (i) signalling even
ts","Toll Like Receptor 5 (TLR5) Cascade","G2/M DNA damage checkpoint","SARS-CoV-1 Infection","Transcriptional Regulation by TP53","HDR through Homologous Recombination (HRR) or Single Strand Annealin
g (SSA)","Signaling by NTRK1 (TRKA)","Signaling by ROBO receptors","Mitotic Metaphase and Anaphase","Caspase activation via Dependence Receptors in the absence of ligand","G1 Phase","VEGFA-VEGFR2 Path
way","RHO GTPases activate PKNs","Interleukin-2 family signaling","G2/M Transition","Host Interactions of HIV factors","Leishmania parasite growth and survival","Oxidative Stress Induced Senescence","
Signaling by AMER1 mutants","Activation of NMDA receptors and postsynaptic events","G0 and Early G1","Toll Like Receptor 4 (TLR4) Cascade","PTK6 promotes HIF1A stabilization","Parasite infection","Sig
naling by FLT3 ITD and TKD mutants","Visual phototransduction","MyD88 cascade initiated on plasma membrane","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","SARS-CoV-1 Genome Replicat
ion and Transcription","Regulation of TP53 Activity","HDR through Homologous Recombination (HRR)","Signalling to ERKs","Activation of RAC1","Mitotic Anaphase","Cyclin D associated events in G1","VEGFR
2 mediated cell proliferation","Interleukin-15 signaling","Centrosome maturation","The role of Nef in HIV-1 replication and disease pathogenesis","Anti-inflammatory response favouring Leishmania paras
ite infection","Truncations of AMER1 destabilize the destruction complex","Post NMDA receptor activation events","MyD88-independent TLR4 cascade","Leishmania phagocytosis","STAT5 activation downstream
 of FLT3 ITD mutants","The phototransduction cascade","MAP kinase activation","Replication of the SARS-CoV-1 genome","Regulation of TP53 Expression and Degradation","Homologous DNA Pairing and Strand 
Exchange","Prolonged ERK activation events","Separation of Sister Chromatids","Regulation of TP53 Activity through Phosphorylation","Loss of proteins required for interphase microtubule organization f
rom the centrosome","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated IL10 synthesis","ADORA2B mediated anti-inflammatory cytokines prod
uction","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3A-mediated phagocytosis","Nef and signal transduction",Inactivat
ion,"recovery and regulation of the phototransduction cascade","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Presynaptic phase of homologous DNA pairing and 
strand exchange","Frs2-mediated activation","Loss of Nlp from mitotic centrosomes","Nef Mediated CD4 Down-regulation","Ras activation upon Ca2+ influx through NMDA receptor","Activation of IRF3/IRF7 m
ediated by TBK1/IKK epsilon","CREB phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Wee1 Inhibitor","Wee1 Inhibitor I",622855-37-2,622855372,"622855 37 2",CHEMBL379975,"4-(2-Chlorophenyl)-9-hydroxypyrrolo(3,4-c)carbazole-1,3-(2H,6H)-dione","4(2Chlorophenyl)9hydroxypyrrolo(3,4c)carb
azole1,3(2H,6H)dione","4 (2 Chlorophenyl) 9 hydro","EMD 681640",681640}

> <pdid>
PD015669

> <targets>
{"Wee1 Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{10384072}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    7.3532   -3.3675    0.0000 C   0  0
    6.3509   -2.2515    0.0000 C   0  0
    4.8823   -2.5608    0.0000 C   0  0
    3.8794   -1.4442    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4135   -4.4923    0.0000 C   0  0
    1.5318   -5.7059    0.0000 C   0  0
    2.1422   -7.0769    0.0000 C   0  0
    1.2586   -8.2891    0.0000 C   0  0
    1.8666   -9.6604    0.0000 C   0  0
    3.3581   -9.8195    0.0000 C   0  0
    4.2417   -8.6074    0.0000 C   0  0
    3.6338   -7.2361    0.0000 C   0  0
    4.5174   -6.0240    0.0000 Cl  0  0
    0.0400   -5.5491    0.0000 C   0  0
   -1.0739   -6.5524    0.0000 C   0  0
   -0.9170   -8.0442    0.0000 O   0  0
   -2.3730   -5.8024    0.0000 N   0  0
   -2.0611   -4.3352    0.0000 C   0  0
   -3.0647   -3.2204    0.0000 O   0  0
   -0.5701   -4.1788    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
  9 11  1  0
 11 12  2  0
 12  6  1  0
 12 13  1  0
 13 14  2  0
 14  5  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 22 23  1  0
 16 24  1  0
 24 25  1  0
 25 26  2  0
 25 27  1  0
 27 28  1  0
 28 29  2  0
 28 30  1  0
 30 13  1  0
 30 24  2  0
M  END
> <name>
UTKinase_V5

> <id>
28246

> <plate>
Kinase v5-1

> <well>
P21

> <supplier_cmpd_name>
681641

> <ctcr_id>
5313

> <supplier_cmpd_id>
EMD 681641

> <smiles>
CCCCn1c2ccc(O)cc2c3c1cc(c4ccccc4Cl)c5C(=O)NC(=O)c35

> <pd_targets>
{WEE1,CHEK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","CAMK protein kinase group","Other protein kinase WEE family","CAMK protein kinase CAMK1 family","CAMK protein kinase CHK1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","CAMK-like (CAMKL) family","WEE family",
"CHK1 subfamily"}

> <pathway_reactome>
{"Cell Cycle","DNA Repair","Cell Cycle Checkpoints","DNA Double-Strand Break Repair","G2/M Checkpoints","Homology Directed Repair","G2/M DNA damage checkpoint","HDR through Homologous Recombination (H
RR) or Single Strand Annealing (SSA)","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","HDR through Homologous Recombination (HRR)","Homologous DNA Pairing and Strand Exchange","Presyn
aptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Wee1 Inhibitor II",CHEMBL215900,622855-50-9,622855509,SCHEMBL5828508,HMS3229P21,BDBM50192400,"6-butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo(3,4-c)carbazole-1,3-dione","6butyl4(2chlorophenyl)9hydroxypy
rrolo(3,4c)carbazole1,3dione","EMD 681641",681641}

> <pdid>
PD015675

> <targets>
{"Wee1 Inhibitor II"}

> <classes>
{}

> <pubchem_cids>
{10319891}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 23  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7554    0.0000 C   0  0
   -3.8938   -2.2554    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -5.2029    2.9932    0.0000 O   0  0
   -6.4990    0.7409    0.0000 N   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0990    0.7364    0.0000 C   0  0
  -10.4007    1.4818    0.0000 C   0  0
  -11.6971    0.7273    0.0000 C   0  0
  -11.6919   -0.7727    0.0000 C   0  0
  -10.3903   -1.5182    0.0000 C   0  0
   -9.0939   -0.7637    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  5  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  3  0
 10 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28247

> <plate>
Kinase v5-1

> <well>
A04

> <supplier_cmpd_name>
AG 490

> <ctcr_id>
7554

> <supplier_cmpd_id>
414

> <smiles>
Oc1ccc(cc1O)\C=C(C#N)\C(=O)NCc2ccccc2

> <pd_targets>
{HIF1A,FFP,TP53,EGFR,KDM4E,SMN1,LMNA,MAPT,CYP2C19,ALOX15,CYP1A2,ALOX12,CHRM1,CYP3A4,GMNN,ERBB2,GRIN1,GRIN2B,GRIN2C,HSD17B10,FTL,KMT2A,MEN1,RECQL,BLM,JAK1,NFKB1,JAK3,PMP22,MAPK1,THPO,ALDH1A1,PKM,HPGD,L
EF,GRIN2A,MTOR,MAP4K2,PLK3,MKNK2,EEF2K,PRKD2,HIPK4,MINK1,MARK2,MAPKAPK2,PIM1,GSK3B,SLK,MAP4K5,PLK4,PRKAA1,TAOK1,IRAK1,AURKB,MAP3K20,AXL,GSK3A,PLK1}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator","Other nuclear protein","Other cytosolic protein","Membrane receptor","Unclassified protein","Ion channel",Transferase,Kinase,Eraser,Reader,"Cytoc
hrome P450",Oxidoreductase,"Family A G protein-coupled receptor","Ligand-gated ion channel",Protease,"Protein Kinase","Lysine demethylase","Methyl-lysine/arginine binding protein","Cytochrome P450 fam
ily 2","Cytochrome P450 family 1","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Ionotropic glutamate receptor",Bromodomain,"Metallo protease","TK protein kinase group","Jumonji
 domain-containing","Tudor domain","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Monoamine receptor","Cytochrome P450 family 3A","NMDA receptor","CMGC protein kinase group","Metallo proteas
e MAE clan","Atypical protein kinase group","Tyrosine protein kinase EGFR family","Cytochrome P450 2C19","Cytochrome P450 1A1","Acetylcholine receptor","Cytochrome P450 3A4","Tyrosine protein kinase J
akA family","CMGC protein kinase MAPK family","Metallo protease M34 family","Atypical protein kinase PIKK family","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","STE protein kinas
e group","Other protein kinase group","CAMK protein kinase group","TKL protein kinase group","STE protein kinase STE20 family","Other protein kinase PLK family","CAMK protein kinase MAPKAPK family","A
typical protein kinase alpha family","CAMK protein kinase PKD family","CMGC protein kinase DYRK family","CAMK protein kinase CAMK1 family","CAMK protein kinase PIM family","CMGC protein kinase GSK fam
ily","TKL protein kinase IRAK family","Other protein kinase AUR family","TKL protein kinase MLK family","Tyrosine protein kinase Axl family","STE protein kinase KHS subfamily","CAMK protein kinase MNK
 subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MARK subfamily","CAMK protein kinase MAPKAPK subfamily","STE protein kinase SLK subfamily","CAM
K protein kinase AMPK subfamily","STE protein kinase TAO subfamily","TKL protein kinase MLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Chromatin modifying enzymes","Cytochrome P450","Eicosanoid turnover","G protein-coupled receptors","Kinases (EC 2.7.x.x)","2.7.1.40 Pyruvate kinases","Recepto
r kinases","1.14.11.- Histone demethylases","CYP2 family: drug metabolising subset",Lipoxygenases,"CYP1 family","Acetylcholine receptors (muscarinic)","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"C
LK families","Prostaglandin synthases",Atypical,"TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Receptor tyrosi
ne kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","FRAP subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Janus kinase (JakA) family","STE: Homologs of
 yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE20 family","Other protein kinases","MAPK-Activated Protein Kinase (MAPKAPK) family","Alpha 
kinase family","Protein kinase D (PKD) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CAMK-like (CAMKL) family","PIM family","Glycogen synthase kinase (GSK) fa
mily","TKL: Tyrosine kinase-like","KHS subfamily","Polo-like kinase (PLK) family","MKN subfamily","eEF2K subfamily","HIPK subfamily","MSN subfamily","MARK subfamily","MAPKAPK subfamily","GSK subfamily
","SLK subfamily","AMPK subfamily","TAO subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","Aurora kinase (Aur) family","Mixed Lineage Kinase (MLK) family","MLK subfamily","Type XI RT
Ks: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{"Cellular responses to external stimuli","Cell Cycle","Signal Transduction","Metabolism of RNA","Neuronal System",Metabolism,"Developmental Biology","Vesicle-mediated transport","DNA Repair","Immune 
System",Hemostasis,Disease,"Gene expression (Transcription)","Cellular responses to stress","Cell Cycle Checkpoints","Signaling by GPCR","Metabolism of non-coding RNA",Mitotic,"Transmission across Che
mical Synapses","Biological oxidations","Metabolism of lipids","Nervous system development","Metabolism of amino acids and derivatives","Membrane Trafficking","DNA Double-Strand Break Repair","Cytokin
e Signaling in Immune system","Innate Immune System","Platelet activation","signaling and aggregation","Metabolism of carbohydrates","Infectious disease","RNA Polymerase II Transcription","Cellular re
sponse to hypoxia","G1/S DNA Damage Checkpoints","GPCR downstream signalling","snRNP Assembly","M Phase","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization 
of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","GPCR ligand binding","Mitotic G1 phase and G1/S transition","Axon guidance","Branched-chain amino acid catabolism","trans-Gol
gi Network Vesicle Budding","Homology Directed Repair","Interferon Signaling","Signaling by Interleukins","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Toll-like Receptor Cascades"
,"Platelet Aggregation (Plug Formation)","Glucose metabolism","Uptake and actions of bacterial toxins","Generic Transcription Pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Fact
or Alpha","p53-Dependent G1/S DNA damage checkpoint","G alpha (q) signalling events","Mitotic Metaphase and Anaphase","Activation of NMDA receptors and postsynaptic events","Cytochrome P450 - arranged
 by substrate type","Biosynthesis of DPA-derived SPMs","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","G1/S Transition","Semaphorin interactions","Golgi Associated Vesicle B
iogenesis","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Antiviral mechanism by IFN-stimulated genes","Interleukin-1 family signaling","Interleukin-2 family signaling"
,"Toll Like Receptor 5 (TLR5) Cascade","Ethanol oxidation",Glycolysis,"Uptake and function of anthrax toxins","Transcriptional Regulation by TP53","p53-Dependent G1 DNA Damage Response","Gastrin-CREB 
signalling pathway via PKC and MAPK","Mitotic Anaphase","Post NMDA receptor activation events",Xenobiotics,"Biosynthesis of DPAn-3 SPMs","Amine ligand-binding receptors","Biosynthesis of maresins","Ac
tivation of the pre-replicative complex","Sema4D in semaphorin signaling","HDR through Homologous Recombination (HRR)","ISG15 antiviral mechanism","Interleukin-1 signaling","Interleukin-15 signaling",
"MyD88 cascade initiated on plasma membrane","Biosynthesis of D-series resolvins","Regulation of TP53 Activity","Stabilization of p53","EGFR Transactivation by Gastrin","Nuclear Envelope (NE) Reassemb
ly","Activation of AMPK downstream of NMDARs","CYP2E1 reactions","Biosynthesis of DPAn-3-derived protectins and resolvins","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthe
sis of DPAn-3-derived maresins","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","Sema4D induced cell migration and growth-cone collapse","Homologous DNA Pairing and Strand Exc
hange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","MAP kinase activation","Regulation of TP53 Expression and Degradation","Autodegradation of the E3 ubiquitin ligase COP1","Initiation of Nuclear Env
elope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","ERK/MAPK targets","ER
Ks are inactivated","MTOR signalling","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","mTORC1-mediated signalling","Sphingol
ipid metabolism","Cellular Senescence","FLT3 signaling in disease","SARS-CoV Infections","Mitotic G2-G2/M phases","Signaling by VEGF","Sphingolipid de novo biosynthesis","Oxidative Stress Induced Sene
scence","Signaling by FLT3 ITD and TKD mutants","SARS-CoV-1 Infection","G2/M Transition","VEGFA-VEGFR2 Pathway","STAT5 activation downstream of FLT3 ITD mutants","SARS-CoV-1 Genome Replication and Tra
nscription","Centrosome maturation","Regulation of TP53 Activity through Phosphorylation","Replication of the SARS-CoV-1 genome","Loss of proteins required for interphase microtubule organization from
 the centrosome","Separation of Sister Chromatids","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK activation","CREB phosphorylation"}

> <broad_targets>
{EGFR,JAK2,JAK3}

> <broad_moa>
{"EGFR inhibitor","JAK inhibitor"}

> <synonyms>
{"G490 (TYRPHOSTIN B42",133550-30-8,133550308,AG-490,AG490,"Tyrphostin B42","AG 490","Tyrphostin AG 490","(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide","(E)Nbenzyl2cyano3(3,4dihydroxyphenyl)
acrylamide","Tyrphostin AG490","tyrphostin AG-490","tyrphostin AG490","AG-490 (Tyrphostin B42)","AG490 (Tyrphostin B42)",alpha-Cyano-(3,alphaCyano(3,4-dihydroxy)-N-benzy,4dihydroxy)Nbenzy,T2600,"EMD 6
58401",EI-272,414,S1143,658401}

> <pdid>
PD002602

> <targets>
{EGFR,JAK}

> <classes>
{}

> <pubchem_cids>
{5328779}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 23  0  0  0  0            999 V2000
    7.5987   -1.2614    0.0000 H   0  3
    5.0987   -1.2614    0.0000 Cl  0  5
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8978   -0.7496    0.0000 S   0  0
   -3.8974    0.7504    0.0000 O   0  0
   -2.5987    0.0002    0.0000 O   0  0
   -5.1981   -1.4992    0.0000 N   0  0
   -5.1012   -3.0033    0.0000 C   0  0
   -6.2014   -4.0229    0.0000 C   0  0
   -7.6846   -3.7984    0.0000 C   0  0
   -8.4337   -2.4989    0.0000 N   0  0
   -7.8848   -1.1029    0.0000 C   0  0
   -6.4512   -0.6617    0.0000 C   0  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14 15  2  0
 14 16  2  0
 14 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 17  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28248

> <plate>
Kinase v5-1

> <well>
A06

> <supplier_cmpd_name>
ML 9 hydrochloride

> <ctcr_id>
3165

> <supplier_cmpd_id>
431

> <smiles>
[H+].[Cl-].Clc1cccc2c1cccc2[S](=O)(=O)N3CCCNCC3

> <pd_targets>
{NPSR1,LMNA,GMNN,CYP3A4,CYP2D6,ROCK1,TP53,CYP2C19,CYP1A2,TSHR,LEF,MYLK,NFKB1,RORC,MTOR,CHRM1,NFO,MAPT,MAPK1,PMP22,KMT2A,MEN1,TRPC6}

> <pathway_gtopdb>
{"Membrane receptor","Other nuclear protein","Unclassified protein",Enzyme,"Transcription factor","Other cytosolic protein","Family A G protein-coupled receptor","Cytochrome P450",Kinase,Protease,"Nuc
lear receptor","Peptide receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Protein Kinase","Cytochrome P450 family 1","Metallo protease","Nuclear hormone receptor subfami
ly 1","Short peptide receptor (family A GPCR)","Cytochrome P450 family 3A","Cytochrome P450 family 2D","AGC protein kinase group","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Glycohormone 
receptor","Metallo protease MAE clan","CAMK protein kinase group","Nuclear hormone receptor subfamily 1 group F","Atypical protein kinase group","Neuropeptide receptor","Cytochrome P450 3A4","Cytochro
me P450 2D6","AGC protein kinase DMPK family","Cytochrome P450 2C19","Cytochrome P450 1A1","Metallo protease M34 family","CAMK protein kinase MLCK family","Nuclear hormone receptor subfamily 1 group F
 member 3","Atypical protein kinase PIKK family","AGC protein kinase ROCK subfamily","Atypical protein kinase FRAP subfamily","Epigenetic regulator","Ion channel",Hydrolase,Reader,"Voltage-gated ion c
hannel","Small molecule receptor (family A GPCR)",Bromodomain,"Transient receptor potential channel","Monoamine receptor","CMGC protein kinase group","Acetylcholine receptor","CMGC protein kinase MAPK
 family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"G protein-coupled receptors","Cytochrome P450","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Neuropeptide S receptor","CYP3 family","CYP2 family: drug metabolising subset","A
GC: Containing PKA",PKG,"PKC families","CYP1 family","Glycoprotein hormone receptors","CAMK: Calcium/calmodulin-dependent protein kinases","1F. Retinoic acid-related orphans",Atypical,"DMPK family","M
yosin Light Chain Kinase (MLCK) family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Rho kinase","FRAP subfamily","Ion channels","Voltage-gated ion channels","Acetylcholine recepto
rs (muscarinic)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Transient Receptor Potential channels","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{Disease,"Cell Cycle",Metabolism,"Developmental Biology","Signal Transduction","Immune System","Gene expression (Transcription)","Infectious disease",Mitotic,"Metabolism of lipids","Biological oxidati
ons","Nervous system development","Cell Cycle Checkpoints","Signaling by Rho GTPases","Cytokine Signaling in Immune system","RNA Polymerase II Transcription","Leishmania infection","M Phase","Mitotic 
G1 phase and G1/S transition","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","Axon guidance","G1/S DNA Damage Checkpoints","Uptake and actions o
f bacterial toxins","RHO GTPase Effectors","Signaling by Interleukins","Generic Transcription Pathway","Leishmania parasite growth and survival","Mitotic Metaphase and Anaphase","G1/S Transition","Bio
synthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Semaphorin interactions","p53-Dependent G1/S DNA damage checkpoint","Uptake and function of anthrax toxins","RHO GTPases 
activate PAKs","Interleukin-1 family signaling","Transcriptional regulation by RUNX3","Transcriptional Regulation by TP53","Anti-inflammatory response favouring Leishmania parasite infection","Mitotic
 Anaphase","Activation of the pre-replicative complex","Biosynthesis of maresins",Xenobiotics,"Sema4D in semaphorin signaling","p53-Dependent G1 DNA Damage Response","Interleukin-1 signaling","RUNX3 R
egulates Immune Response and Cell Migration","Regulation of TP53 Activity","ADORA2B mediated anti-inflammatory cytokines production","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SP
Ms","CYP2E1 reactions","Sema4D induced cell migration and growth-cone collapse","Stabilization of p53","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent MAPK1
/3 activation","Regulation of TP53 Expression and Degradation","Initiation of Nuclear Envelope (NE) Reformation","Autodegradation of the E3 ubiquitin ligase COP1","Regulation of TP53 Degradation","Neu
ronal System","Signaling by GPCR","Transmission across Chemical Synapses","Innate Immune System","GPCR ligand binding","Neurotransmitter receptors and postsynaptic signal transmission","Toll-like Rece
ptor Cascades","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Class A/1 (Rhodopsin-like receptors)","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 5 (TLR
5) Cascade","Netrin-1 signaling","Amine ligand-binding receptors","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","Role of second messengers in netrin-1 signaling",
"Muscarinic acetylcholine receptors","Activation of AMPK downstream of NMDARs","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{TRPC6}

> <broad_moa>
{"myosin light chain kinase inhibitor"}

> <synonyms>
{ML-9,ML9,"ML 9",105637-50-1,105637501,"105637 50 1","ML-9 hydrochloride","ML9 hydrochloride","ML 9 hydrochloride","ML-9 HCl","ML9 HCl","ML 9 HCl",UNII-BZ2L6JK93I,UNIIBZ2L6JK93I,"UNII BZ2L6JK93I",1-((
5-Chloronaphthalen-1-yl)sulfonyl)-,1((5Chloronaphthalen1yl)sulfonyl),EI-153,431,ML-9?HCl}

> <pdid>
PD015772

> <targets>
{"Serine/threonin kinase",MLCK}

> <classes>
{}

> <pubchem_cids>
{108047,67238067}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 30  0  0  0  0            999 V2000
    8.5188  -12.2439    0.0000 I   0  5
    5.4020  -25.9871    0.0000 C   0  0
    6.0188  -24.6197    0.0000 C   0  0
    5.1434  -23.4007    0.0000 C   0  0
    5.7605  -22.0326    0.0000 C   0  0
    4.8851  -20.8136    0.0000 C   0  0
    5.5023  -19.4455    0.0000 C   0  0
    4.6269  -18.2264    0.0000 C   0  0
    5.2441  -16.8584    0.0000 C   0  0
    4.3686  -15.6393    0.0000 C   0  0
    4.9858  -14.2713    0.0000 C   0  0
    4.1104  -13.0522    0.0000 C   0  0
    4.7276  -11.6841    0.0000 C   0  0
    3.8522  -10.4651    0.0000 C   0  0
    4.4693   -9.0970    0.0000 C   0  0
    3.5939   -7.8779    0.0000 C   0  0
    4.2111   -6.5099    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    1.8372   -5.2877    0.0000 C   0  0
    1.3786   -3.8595    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  3
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8056   -3.8679    0.0000 C   0  0
    5.2311   -3.4009    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 21 29  2  0
 29 18  1  0
 29 30  1  0
M  CHG  2   1  -1  21   1
M  END
> <name>
UTKinase_V5

> <id>
28249

> <plate>
Kinase v5-1

> <well>
A08

> <supplier_cmpd_name>
NH 125

> <ctcr_id>
1996

> <supplier_cmpd_id>
3439

> <smiles>
[I-].CCCCCCCCCCCCCCCCn1cc[n+](Cc2ccccc2)c1C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NH125,278603-08-0,278603080,"eEF-2 Kinase Inhibitor, NH125","eEF2 Kinase Inhibitor, NH125","1-Benzyl-3-cetyl-2-methylimidazolium iodide","1Benzyl3cetyl2methylimidazolium iodide","NH 125",nh-125,nh125
,"1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide","1Hexadecyl2methyl3(phenylmethyl)1Himidazolium iodide",MFCD07370143,"3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide","3Benzyl1hex
adecyl2methyl1Himidazol3ium iodide",CH,"EMD 324515",3439,324515}

> <pdid>

> <targets>
{"eEF-2 Kinase Inhibitor",NH125,"CaM Kinase III"}

> <classes>
{}

> <pubchem_cids>
{10436839}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 22  0  0  0  0            999 V2000
   12.1347   -0.9886    0.0000 H   0  3
    9.6347   -0.9886    0.0000 Cl  0  5
    2.5983   -3.0004    0.0000 O   0  0
    2.5988   -1.5004    0.0000 S   0  0
    3.8975   -2.2510    0.0000 O   0  0
    3.8990   -0.7508    0.0000 N   0  0
    5.1522   -1.5883    0.0000 C   0  0
    6.5858   -1.1471    0.0000 C   0  0
    7.1347    0.2489    0.0000 C   0  0
    6.3855    1.5484    0.0000 N   0  0
    4.9024    1.7729    0.0000 C   0  0
    3.8022    0.7533    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  2  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  6  1  0
  4 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 13  1  0
 22 17  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28250

> <plate>
Kinase v5-1

> <well>
A10

> <supplier_cmpd_name>
Fasudil hydrochloride

> <ctcr_id>
4951

> <supplier_cmpd_id>
541

> <smiles>
[H+].[Cl-].O=[S](=O)(N1CCCNCC1)c2cccc3cnccc23

> <pd_targets>
{ROCK2,ROCK1,HTT,PRKCD,CDK8,PRKACA,RPS6KA3,AURKB,PRKX,PRKCG,PRKCE,CYP3A4,CYP2D6,PRKCQ,PRKD2,MAP4K4,LRRK2,DAPK3,PRKG1,PRKACB,PRKACG,PKN2,LEF,MYLK,KCNH2,SGK2,CDK5,PRKD3,CLK4,CDK7,RPS6KB1,KMT2A,MEN1,AKT1
,SMN1,AKT3,PKN1,CHEK2,STK33,CCR2,RPS6KA5,CCL2}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Ion channel","Epigenetic regulator","Membrane receptor",Kinase,"Cytochrome P450",Protease,"Voltage-gated ion channel",Reader,"Family A G protein-coupled receptor","Prot
ein Kinase","Cytochrome P450 family 3","Cytochrome P450 family 2","Metallo protease","Potassium channels",Bromodomain,"Methyl-lysine/arginine binding protein","Peptide receptor (family A GPCR)","AGC p
rotein kinase group","CMGC protein kinase group","Other protein kinase group","Cytochrome P450 family 3A","Cytochrome P450 family 2D","CAMK protein kinase group","STE protein kinase group","TKL protei
n kinase group","Metallo protease MAE clan","Voltage-gated potassium channel","Tudor domain","Chemokine receptor","AGC protein kinase DMPK family","AGC protein kinase PKC family","CMGC protein kinase 
CDK family","AGC protein kinase PKA family","AGC protein kinase RSK family","Other protein kinase AUR family","Cytochrome P450 3A4","Cytochrome P450 2D6","CAMK protein kinase PKD family","STE protein 
kinase STE20 family","TKL protein kinase LRRK family","CAMK protein kinase DAPK family","AGC protein kinase PKG family","AGC protein kinase PKN family","Metallo protease M34 family","CAMK protein kina
se MLCK family","AGC protein kinase SGK family","CMGC protein kinase CLK family","AGC protein kinase AKT family","CAMK protein kinase RAD53 family","CAMK protein kinase unique family","CC chemokine re
ceptor","AGC protein kinase ROCK subfamily","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDK8 subfamily","AGC protein kinase RSK subfamily","AGC protein kinase PKC alpha subfamily","A
GC protein kinase PKC eta subfamily","STE protein kinase MSN subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK7 subfamily","AGC protein kinase p70 subfamily","AGC protein kinase
 MSK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Catalytic receptors","Cytochrome P450","Voltage-gated ion channels","G protein-coupled receptors","AGC: Containing PKA",PKG,"PKC families","CM
GC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CYP3 family","CYP2 family: drug metabolising subset","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Steri
le 7","Sterile 11","Sterile 20 kinases","Potassium channels","Chemokine receptors","DMPK family","Protein kinase C (PKC) family","Cyclin-dependent kinase (CDK) family","Protein kinase A (PKA) family",
"RSK family","Other protein kinases","Protein kinase D (PKD) family","STE20 family","TKL: Tyrosine kinase-like","Death-associated kinase (DAPK) family","Protein kinase G (PKG) family","Protein kinase 
N (PKN) family","Myosin Light Chain Kinase (MLCK) family","Voltage-gated potassium channels","SGK family","CLK family","Akt (Protein kinase B","PKB) family","CAMK-like (CAMKL) family","CAMK-unique fam
ily","Rho kinase","Delta subfamily","CDK8 subfamily","RSK subfamily","Aurora kinase (Aur) family","Alpha subfamily","Eta subfamily","MSN subfamily","Leucine-rich repeat kinase (LRRK) family","CDK5 sub
family","CDK7 subfamily","p70 subfamily","CHK1 subfamily","MSK subfamily"}

> <pathway_reactome>
{"Developmental Biology","Gene expression (Transcription)","Signal Transduction",Disease,"Cell Cycle","Immune System","Neuronal System",Metabolism,"Cellular responses to external stimuli","Programmed 
Cell Death",Hemostasis,"Muscle contraction","Transport of small molecules","Metabolism of RNA","Nervous system development","RNA Polymerase II Transcription","Intracellular signaling by second messeng
ers","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Innate Immune System","Infectious disease","Transmission across Chemical Synapses","Metabolism of lipid
s","Biological oxidations","Signaling by GPCR","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases",Apoptosis,"Platelet homeostasis","Signaling by Rho GTPases","Cardiac conducti
on","Ion channel transport","MTOR signalling","Metabolism of non-coding RNA","Axon guidance","Generic Transcription Pathway","DAG and IP3 signaling","Signaling by NOTCH1 in Cancer","Mitotic G2-G2/M ph
ases","Toll-like Receptor Cascades","M Phase","Leishmania infection","Neurotransmitter receptors and postsynaptic signal transmission","Fcgamma receptor (FCGR) dependent phagocytosis","Biosynthesis of
 specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","GPCR downstream signalling","Sphingolipid metabolism","Cellular Senescence","Signaling by PTK6","Caspase activat
ion via extrinsic apoptotic signalling pathway","Nitric oxide stimulates guanylate cyclase","RHO GTPase Effectors","Uptake and actions of bacterial toxins","Phase 3 - rapid repolarisation","Stimuli-se
nsing channels","HIV Infection","mTORC1-mediated signalling","snRNP Assembly","GPCR ligand binding","Semaphorin interactions","Transcriptional Regulation by MECP2","CaM pathway","Signaling by NOTCH1 H
D+PEST Domain Mutants in Cancer","G2/M Transition","Toll Like Receptor 5 (TLR5) Cascade","Mitotic Metaphase and Anaphase","Leishmania parasite growth and survival","Glutamate binding","activation of A
MPA receptors and synaptic plasticity","Role of phospholipids in phagocytosis","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","G alpha (i) signalling events","Sphing
olipid de novo biosynthesis","Oxidative Stress Induced Senescence","PTK6 promotes HIF1A stabilization","Caspase activation via Dependence Receptors in the absence of ligand","cGMP effects","RHO GTPase
s activate PKNs","Uptake and function of anthrax toxins","RHO GTPases activate PAKs","Transcriptional Regulation by TP53","HIV Life Cycle","Class A/1 (Rhodopsin-like receptors)","Sema4D in semaphorin 
signaling","Regulation of MECP2 expression and activity","Calmodulin induced events","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Centrosome maturation","MyD88 cascade initiated on plasm
a membrane","Mitotic Anaphase","Anti-inflammatory response favouring Leishmania parasite infection","Trafficking of AMPA receptors","Biosynthesis of maresins",Xenobiotics,"Visual phototransduction","R
egulation of TP53 Activity","Late Phase of HIV Life Cycle","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Peptide ligand-binding receptors","Sema4D 
induced cell migration and growth-cone collapse","Loss of proteins required for interphase microtubule organization from the centrosome","MAP kinase activation","Separation of Sister Chromatids","ADOR
A2B mediated anti-inflammatory cytokines production","Trafficking of GluR2-containing AMPA receptors","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","The phototransduction cascade","Regulation
 of TP53 Activity through Phosphorylation","Transcription of the HIV genome","Regulation of TP53 Expression and Degradation","PKA-mediated phosphorylation of CREB","Chemokine receptors bind chemokines
","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases",Inactivation,"recovery and regulation of the phototransduction cascade","HIV Transcription Elongation","
Regulation of TP53 Degradation","PKA activation","CREB phosphorylation","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{PKIA,PRKACA,ROCK1,ROCK2}

> <broad_moa>
{"rho associated kinase inhibitor"}

> <synonyms>
{"ASUDIL (HA1077) HC","ASUDIL (HA 1077) HC","1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-,monohydrochloride","1H1,4Diazepine, hexahydro1(5isoquinolinylsulfonyl),monohydrochloride","1H 1","
4 Diazepine","hexahydro 1 (5 isoqui",541,S1573,"Fasudil hydrochloride","Fasudil (HA-1077) HCl"}

> <pdid>
PD001304

> <targets>
{Rho-kinases,ROCK,Autophagy}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{657249,163751}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  0  0            999 V2000
   -1.7616   -9.1692    0.0000 C   0  0
   -0.7600   -8.0526    0.0000 N   0  0
    0.7077   -8.3622    0.0000 C   0  0
   -1.2256   -6.6258    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.2559   -4.6520    0.0000 C   0  0
    5.8646   -6.1001    0.0000 N   0  0
    4.3672   -6.1750    0.0000 C   0  0
    3.4207   -7.3387    0.0000 C   0  0
    1.9397   -7.1008    0.0000 C   0  0
    1.4052   -5.6993    0.0000 C   0  0
    2.3517   -4.5356    0.0000 C   0  0
    3.8327   -4.7735    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  7  1  0
 15 10  1  0
  9 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 16  1  0
 21 22  2  0
 17 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 23  1  0
 31 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28251

> <plate>
Kinase v5-1

> <well>
A12

> <supplier_cmpd_name>
GF 109203X

> <ctcr_id>
200

> <supplier_cmpd_id>
741

> <smiles>
CN(C)CCCn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45

> <pd_targets>
{PRKCE,RECQL,SMN1,MAPT,FFP,FTL,PHKA1,PRKCA,PIM1,SIRT2,PRKCZ,CYP3A4,PRKACA,PRKCB,PRKCH,SIRT1,MAPK1,TSHR,CYP2C9,GSK3B,PRKCQ,PRKCG,CCND1,CDK4,CCNB1,CCNB2,CCNB3,CDK1,KMT2A,MEN1,CYP1A2,PFMRK,PRKCD,CCNE1,CC
NE2,CDK2,LEF,TP53,PRKCI,KCNH2,LMTK3}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Unclassified protein","Membrane receptor","Transcription factor","Ion channel",Kinase,Reader,Transferase,Eraser,"Cytochrome P450","Family A G 
protein-coupled receptor",Protease,"Voltage-gated ion channel","Protein Kinase","Methyl-lysine/arginine binding protein","Histone deacetylase","Cytochrome P450 family 3","Peptide receptor (family A GP
CR)","Cytochrome P450 family 2",Bromodomain,"Cytochrome P450 family 1","Metallo protease","Potassium channels","AGC protein kinase group","Tudor domain","CAMK protein kinase group","HDAC class III","C
ytochrome P450 family 3A","CMGC protein kinase group","Glycohormone receptor","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Metallo protease MAE clan","Voltage-gated potassium channel","AGC
 protein kinase PKC family","CAMK protein kinase PIM family","Cytochrome P450 3A4","AGC protein kinase PKA family","CMGC protein kinase MAPK family","Cytochrome P450 2C9","CMGC protein kinase GSK fami
ly","CMGC protein kinase CDK family","Cytochrome P450 1A1","Metallo protease M34 family","AGC protein kinase PKC eta subfamily","AGC protein kinase PKC alpha subfamily","AGC protein kinase PKC iota su
bfamily","CMGC protein kinase ERK1","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Cytochrome P450","G protein-coupled receptors","Voltage-gated ion channels","Catalytic receptors","AGC: Containi
ng PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","3.5.1.- Histone deacetylases (HDACs)","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Glycoprotein hormo
ne receptors","CYP2 family: drug metabolising subset","CYP1 family","Potassium channels","Receptor kinases","Protein kinase C (PKC) family","PIM family","Protein kinase A (PKA) family","Mitogen-activa
ted protein kinases (MAP kinases)","Glycogen synthase kinase (GSK) family","Voltage-gated potassium channels","TK: Tyrosine kinase","Eta subfamily","Delta subfamily","Iota subfamily","Alpha subfamily"
,"ERK subfamily","GSK subfamily","Receptor tyrosine kinases (RTKs)","Type XVIII RTKs: LMR family"}

> <pathway_reactome>
{"Immune System","Metabolism of RNA","Neuronal System","Vesicle-mediated transport","Signal Transduction",Disease,"Cell Cycle",Metabolism,"Gene expression (Transcription)","Muscle contraction","Innate
 Immune System","Metabolism of non-coding RNA","Transmission across Chemical Synapses","Membrane Trafficking","Signaling by GPCR","Diseases of signal transduction by growth factor receptors and second
 messengers",Mitotic,"Signaling by Nuclear Receptors","Metabolism of lipids","RNA Polymerase II Transcription","Infectious disease","Biological oxidations","Intracellular signaling by second messenger
s","Cell Cycle Checkpoints","Death Receptor Signalling","Cardiac conduction","Fcgamma receptor (FCGR) dependent phagocytosis","snRNP Assembly","Neurotransmitter receptors and postsynaptic signal trans
mission","trans-Golgi Network Vesicle Budding","GPCR downstream signalling","FLT3 signaling in disease","M Phase","ESR-mediated signaling","Biosynthesis of specialized proresolving mediators (SPMs)","
Mitotic G2-G2/M phases","Generic Transcription Pathway","Toll-like Receptor Cascades","Leishmania infection","Phase I - Functionalization of compounds","SARS-CoV Infections","DAG and IP3 signaling","U
ptake and actions of bacterial toxins","G1/S DNA Damage Checkpoints","p75 NTR receptor-mediated signalling","Phase 3 - rapid repolarisation","Role of phospholipids in phagocytosis","Activation of NMDA
 receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis","G alpha (i) signalling events","Signaling by FLT3 ITD and TKD mutants","Mitotic Metaphase and Anaphase","Extra-nuclear estrog
en signaling","Biosynthesis of DHA-derived SPMs","G2/M Transition","Mitotic Prophase","G alpha (z) signalling events","FOXO-mediated transcription","Toll Like Receptor 5 (TLR5) Cascade","Leishmania pa
rasite growth and survival","Cytochrome P450 - arranged by substrate type","SARS-CoV-1 Infection","Glutamate binding","activation of AMPA receptors and synaptic plasticity","CaM pathway","Uptake and f
unction of anthrax toxins","p53-Dependent G1/S DNA damage checkpoint","p75NTR signals via NF-kB","Post NMDA receptor activation events","Visual phototransduction","STAT5 activation downstream of FLT3 
ITD mutants","Mitotic Anaphase","Estrogen-stimulated signaling through PRKCZ","Biosynthesis of maresins","Centrosome maturation","Nuclear Envelope Breakdown","Regulation of FOXO transcriptional activi
ty by acetylation","MyD88 cascade initiated on plasma membrane","Anti-inflammatory response favouring Leishmania parasite infection",Xenobiotics,"SARS-CoV-1 Genome Replication and Transcription","Traf
ficking of AMPA receptors","Calmodulin induced events","p53-Dependent G1 DNA Damage Response","p75NTR recruits signalling complexes","Activation of AMPK downstream of NMDARs","The phototransduction ca
scade","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","Loss of proteins required for interphase microtubule organization from the centrosome","Depolymerisation of the Nuclear L
amina","MAP kinase activation","ADORA2B mediated anti-inflammatory cytokines production","CYP2E1 reactions","Replication of the SARS-CoV-1 genome","Trafficking of GluR2-containing AMPA receptors","Aro
matic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Stabilization of p53",Inactivation,"recovery and regulation of the phototransduction cascade","Initiation of Nuclear Envelope (NE) Refor
mation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{PDPK1,PIM1,PRKCI,PRKCZ}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{"bisindolylmaleimide i",133052-90-1,133052901,"GF 109203X",GF109203X,"Go 6850",GF-109203X,Go-6850,Go6850,UNII-L79H6N0V6C,UNIIL79H6N0V6C,2-(1-(3-dimethylaminopropyl)indol-3-yl)-3-(indol-3-yl)maleimide
,2(1(3dimethylaminopropyl)indol3yl)3(indol3yl)maleimide,"G&ouml; 6850",CHEMBL7463,L79H6N0V6C,2-(1-(3-Dimethylaminopropyl)indol-3-y,2(1(3Dimethylaminopropyl)indol3y,T6513,"EMD 203290",SY-GF109203X,741,
EI-246,"Bisindolylmaleimide I",203290,"GF109203X (Bisindolylmaleimide I)"}

> <pdid>
PD007247

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{2396}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 11  1  0
 18 19  1  0
 19  8  1  0
 19 20  2  0
M  END
> <name>
UTKinase_V5

> <id>
28252

> <plate>
Kinase v5-1

> <well>
A14

> <supplier_cmpd_name>
Genistein

> <ctcr_id>
2985

> <supplier_cmpd_id>
1110

> <smiles>
Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O

> <pd_targets>
{ALDH1A1,TSHR,SMN1,PMP22,MAPT,CYP2C19,ALOX15,AKR1B1,SLC2A1,MAOA,ESR2,XDH,PYK,MAPK1,NPC1,ESR1,MAL32,EGFR,ABL1,MGAM,ADORA2A,ADORA1,ESRRA,PTGS1,HPGD,TP53,CYP1A2,HSD17B3,HSD17B2,POL,MAOB,MAPK14,DPP3,SRC,N
A,ESRRB,LMNA,SYK,CYP3A4,AOX1,PFMRK,AR,CFTR,ABCB1,KMT2A,MEN1,RAB9A,HIF1A,LEF,THPO,PSMB5,ODC1,DAPK1,NANH,FABZ,TDP1,SHBG,DPP4,FTL,PKM,PRKCA,POLB,RORC,SLCO1B1,DNMT1,CACNA1C,NR1H2,CYP19A1,ABCG2,SLC2A4,NR1H
3,HTR2A,SLC6A3,SLCO1B3,BMX,HSD17B1,HTR2C,TBXAS1,STAT3,FYN,TRPC5,ESRRG}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Epigenetic regulator","Unclassified protein","Other cytosolic protein",Transporter,"Transcription factor","Other nuclear protein","Ion channel","Secreted protein",Oxidored
uctase,"Family A G protein-coupled receptor",Reader,"Cytochrome P450",Protease,"Electrochemical transporter","Nuclear receptor",Transferase,Kinase,Hydrolase,"Other ion channel","Primary active transpo
rter",Lyase,Writer,"Voltage-gated ion channel","Peptide receptor (family A GPCR)","Methyl-lysine/arginine binding protein","Cytochrome P450 family 2","Cysteine protease","SLC superfamily of solute car
riers","Nuclear hormone receptor subfamily 3","Protein Kinase","Small molecule receptor (family A GPCR)","Cytochrome P450 family 1","Metallo protease","Cytochrome P450 family 3","Chloride channel","AT
P-binding cassette",Bromodomain,"Threonine protease","Serine protease","Nuclear hormone receptor subfamily 1","DNA methyltransferase","Voltage-gated calcium channel","Cytochrome P450 family 19","Cytoc
hrome P450 family 5","Transient receptor potential channel","Glycohormone receptor","Tudor domain","Cytochrome P450 family 2C","Cysteine protease CA clan","SLC02 family of hexose and sugar alcohol tra
nsporters","Nuclear hormone receptor subfamily 3 group A","CMGC protein kinase group","TK protein kinase group","Nucleotide-like receptor (family A GPCR)","Nuclear hormone receptor subfamily 3 group B
","Cytochrome P450 family 1A","Metallo protease MAE clan","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 3 group C","Cystic fibrosis transmembrane conductance regulator","ABCB subfami
ly","Threonine protease PBT clan","CAMK protein kinase group","Serine protease SC clan","AGC protein kinase group","Nuclear hormone receptor subfamily 1 group F","SLC21/SLCO family of organic anion tr
ansporting polypeptides","Nuclear hormone receptor subfamily 1 group H","Cytochrome P450 family 19A","ABCG subfamily","Monoamine receptor","SLC06 neurotransmitter transporter family","Cytochrome P450 
family 5A","Cytochrome P450 2C19","Cysteine protease C1A family","Nuclear hormone receptor subfamily 3 group A member 2","CMGC protein kinase MAPK family","Nuclear hormone receptor subfamily 3 group A
 member 1","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Abl family","Adenosine receptor","Nuclear hormone receptor subfamily 3 group B member 1","Cytochrome P450 1A1","Metallo protea
se M49 family","Tyrosine protein kinase Src family","Nuclear hormone receptor subfamily 3 group B member 2","Tyrosine protein kinase Syk family","Cytochrome P450 3A4","CMGC protein kinase CDK family",
"Nuclear hormone receptor subfamily 3 group C member 4","Metallo protease M34 family","Threonine protease T1A subfamily","CAMK protein kinase DAPK family","Serine protease S9B subfamily","AGC protein 
kinase PKC family","Nuclear hormone receptor subfamily 1 group F member 3","Nuclear hormone receptor subfamily 1 group H member 3","Cytochrome P450 19A1","Serotonin receptor","Tyrosine protein kinase 
Tec family","Cytochrome P450 5A1","Nuclear hormone receptor subfamily 3 group B member 3","CMGC protein kinase ERK1","CMGC protein kinase p38 subfamily","AGC protein kinase PKC alpha subfamily","Tyros
ine protein kinase SrcA"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Ion channels","Other protein targets","G protein-coupled receptors","Cytochrome P450","Eicosanoid turnover","1.-.-.- Oxidoreductases","SLC superfamily of solute carrie
rs","Catecholamine turnover","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Catalytic receptors","3.2.1.- Glycosidases","Peptidases and proteinases","Other ion channels","ATP-binding cassette tra
nsporter family","Carboxylases and decarboxylases","2.7.1.40 Pyruvate kinases","2.1.1.- Methyltransferases","Voltage-gated ion channels","Transcription factors","Glycoprotein hormone receptors","CYP2 
family: drug metabolising subset",Lipoxygenases,"SLC2 family of hexose and sugar alcohol transporters","Steroid hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","SLC65 NPC-type chole
sterol transporters","Receptor kinases","Adenosine receptors","3B. Estrogen-related receptors",Cyclooxygenase,"Prostaglandin synthases","CYP1 family","MA: Metallo (M) Peptidases","CYP3 family","Chlori
de channels","ABCB subfamily","PB: Threonine (T) Peptidases",Decarboxylases,"CAMK: Calcium/calmodulin-dependent protein kinases","SC: Serine (S) Peptidases","AGC: Containing PKA",PKG,"PKC families","1
F. Retinoic acid-related orphans","SLCO family of organic anion transporting polypeptides","Voltage-gated calcium channels","1H. Liver X receptor-like receptors",CYP11,CYP17,CYP19,"CYP20 and CYP21 fam
ilies","ABCG subfamily","5-Hydroxytryptamine receptors","SLC6 neurotransmitter transporter family",CYP5,"CYP7 and CYP8 families","STAT transcription factors","Transient Receptor Potential channels","C
lass I transporters","3A. Estrogen receptors","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","M49: Dipeptidyl-peptidase III","3C. 3-Ketosteroid receptors",CFTR,"T1: Proteasome
","Death-associated kinase (DAPK) family","S9: Prolyl oligopeptidase","Protein kinase C (PKC) family","Monoamine transporter subfamily","ERK subfamily","Receptor tyrosine kinases (RTKs)","Non-receptor
 tyrosine kinases (nRTKs)","p38 subfamily","Delta subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Abl family","Src family","Syk family","Tec family"}

> <pathway_reactome>
{Metabolism,Disease,"Metabolism of RNA","Developmental Biology","Neuronal System","Signal Transduction","Immune System","Transport of small molecules","Gene expression (Transcription)","Digestion and 
absorption","Cell Cycle",Autophagy,"Cellular responses to external stimuli",Hemostasis,"Programmed Cell Death","DNA Repair","Metabolism of proteins","Vesicle-mediated transport","Biological oxidations
","Infectious disease","Metabolism of non-coding RNA","Nervous system development","Transmission across Chemical Synapses","Metabolism of lipids","Disorders of transmembrane transporters","Intracellul
ar signaling by second messengers","Metabolism of nucleotides","Innate Immune System","Plasma lipoprotein assembly",remodeling,"and clearance","RNA Polymerase II Transcription","Signaling by GPCR",Dig
estion,"Cell Cycle Checkpoints","Signaling by Receptor Tyrosine Kinases",Mitotic,"Metabolism of vitamins and cofactors",Macroautophagy,"Abacavir transport and metabolism","Signaling by Rho GTPases","C
ellular responses to stress","Platelet activation","signaling and aggregation","Metabolism of amino acids and derivatives",Apoptosis,"DNA Double-Strand Break Repair","Peptide hormone metabolism","Memb
rane Trafficking","Metabolism of carbohydrates","Base Excision Repair","Post-translational protein modification","SLC-mediated transmembrane transport","Diseases of signal transduction by growth facto
r receptors and second messengers","Phase I - Functionalization of compounds","Leishmania infection","snRNP Assembly","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Neurotransmitter
 receptors and postsynaptic signal transmission","Biosynthesis of specialized proresolving mediators (SPMs)","Metabolism of steroids","SLC transporter disorders","PIP3 activates AKT signaling","Nucleo
base catabolism","Toll-like Receptor Cascades","Plasma lipoprotein clearance","Generic Transcription Pathway","GPCR downstream signalling","Digestion of dietary carbohydrate","GPCR ligand binding","Fa
tty acid metabolism","G1/S DNA Damage Checkpoints","Signaling by NTRKs","Influenza Infection","M Phase","Metabolism of water-soluble vitamins and cofactors","Selective autophagy","Abacavir transmembra
ne transport","Rho GTPase cycle","Cellular response to hypoxia","Uptake and actions of bacterial toxins","Platelet Aggregation (Plug Formation)","Regulation of mitotic cell cycle","Metabolism of polya
mines","Caspase activation via extrinsic apoptotic signalling pathway","Nonhomologous End-Joining (NHEJ)","Incretin synthesis",secretion,"and inactivation","trans-Golgi Network Vesicle Budding","Gluco
se metabolism","Resolution of Abasic Sites (AP sites)",SUMOylation,"Axon guidance","Cellular hexose transport","Phospholipid metabolism","Signaling by FGFR in disease","HIV Infection","Ethanol oxidati
on","Leishmania parasite growth and survival","Activation of NMDA receptors and postsynaptic events","Cytochrome P450 - arranged by substrate type","Biosynthesis of DPA-derived SPMs","Metabolism of st
eroid hormones","Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)","Amine Oxidase reactions","Negative regulation of the PI3K/AKT network","Purine catabolism","Toll Like Receptor 5 (TLR5
) Cascade","LDL clearance","Transcriptional regulation by RUNX1","G alpha (q) signalling events","Parasite infection","Class A/1 (Rhodopsin-like receptors)","Transcriptional regulation by RUNX2","Arac
hidonic acid metabolism","Biosynthesis of DHA-derived SPMs","p53-Dependent G1/S DNA damage checkpoint","Fatty acyl-CoA biosynthesis","Signaling by NTRK1 (TRKA)","Virus Assembly and Release","Nuclear R
eceptor transcription pathway","Mitotic Metaphase and Anaphase","Vitamins B6 activation to pyridoxal phosphate",Aggrephagy,"RHOBTB GTPase Cycle","Oxygen-dependent proline hydroxylation of Hypoxia-indu
cible Factor Alpha","Uptake and function of anthrax toxins","APC/C-mediated degradation of cell cycle proteins","Regulation of ornithine decarboxylase (ODC)","Caspase activation via Dependence Recepto
rs in the absence of ligand",Synthesis,"and inactivation of Glucagon-like Peptide-1 (GLP-1)","Golgi Associated Vesicle Biogenesis",Glycolysis,"G alpha (i) signalling events","Resolution of AP sites vi
a the multiple-nucleotide patch replacement pathway","Transcriptional regulation by RUNX3","Bile acid and bile salt metabolism","SUMO E3 ligases SUMOylate target proteins","NCAM signaling for neurite 
out-growth","Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)","PI Metabolism","Signaling by FGFR1 in disease","Host Interactions of HIV factors","Netrin-1 signaling","Anti-inflammatory
 response favouring Leishmania parasite infection","Post NMDA receptor activation events",Xenobiotics,"Biosynthesis of DPAn-3 SPMs","Pregnenolone biosynthesis","Biogenic amines are oxidatively deamina
ted to aldehydes by MAOA and MAOB",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","MyD88 cascade initiated on plasma membrane","RUNX1 regulates estrogen receptor mediated transcription","Gastrin-CRE
B signalling pathway via PKC and MAPK","Leishmania phagocytosis","Nucleotide-like (purinergic) receptors","Regulation of RUNX2 expression and activity","Synthesis of Prostaglandins (PG) and Thromboxan
es (TX)","Biosynthesis of D-series resolvins","p53-Dependent G1 DNA Damage Response","Synthesis of very long-chain fatty acyl-CoAs","Estrogen biosynthesis","Signalling to ERKs","Assembly of Viral Comp
onents at the Budding Site","Mitotic Anaphase","Biosynthesis of maresins","RUNX2 regulates bone development","RHOBTB3 ATPase cycle","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic
 proteins","Visual phototransduction","PCNA-Dependent Long Patch Base Excision Repair","RUNX3 Regulates Immune Response and Cell Migration","Recycling of bile acids and salts","SUMOylation of DNA meth
ylation proteins","NCAM1 interactions","SUMOylation of intracellular receptors","Endogenous sterols","Amine ligand-binding receptors","Synthesis of PIPs at the plasma membrane",Eicosanoids,"FGFR1 muta
nt receptor activation","The role of Nef in HIV-1 replication and disease pathogenesis","Role of second messengers in netrin-1 signaling","ADORA2B mediated anti-inflammatory cytokines production","Act
ivation of AMPK downstream of NMDARs","CYP2E1 reactions","Biosynthesis of DPAn-3-derived protectins and resolvins","MAP kinase activation","EGFR Transactivation by Gastrin","FCGR3A-mediated phagocytos
is","Adenosine P1 receptors","Stabilization of p53","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Signalling to RAS","Transport of HA trimer","NA tetramer and M2 tetramer from th
e endoplasmic reticulum to the Golgi Apparatus","Nuclear Envelope (NE) Reassembly","FCGR3A-mediated IL10 synthesis","Biosynthesis of maresin-like SPMs","RUNX2 regulates osteoblast differentiation","AP
C/C:Cdc20 mediated degradation of mitotic proteins","The phototransduction cascade","Serotonin receptors","The canonical retinoid cycle in rods (twilight vision)","Signaling by cytosolic FGFR1 fusion 
mutants","Nef and signal transduction","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","p38MAPK events","Initiation of Nuclear Envelope (NE) Re
formation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",Inactivation,"recovery and regulation of the phototransduction cascade","ERK/MAPK t
argets","Activation of the AP-1 family of transcription factors","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CFTR,ESR1,ESR2,ESRRA,ESRRB,ESRRG,NCOA1,NCOA2,PPARG,PTK2B,TOP2A,TRPC5}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{genistein,446-72-0,446720,Prunetol,"4',5,7-Trihydroxyisoflavone","4',5,7Trihydroxyisoflavone",Genisterin,Genisteol,Sophoricol,"5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one","5,7dihydroxy3(4hydr
oxyphenyl)4Hchromen4one","5,7,4'-Trihydroxyisoflavone","5,7,4'Trihydroxyisoflavone",Bonistein,"Differenol A",5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one,7dihydroxy3(4hydroxyphenyl)chromen4one,T1737
,NSC36586,1110,210296,EI-147,"NSC 36586",Genistein,GENISTEIN}

> <pdid>
PD002146

> <targets>
{EGFR,"Tyrosine Kinases",Apoptosis,Autophagy,"Endogenous Metabolite"}

> <classes>
{Apoptosis,Autophagy,JAK/STAT Signaling,Metabolic Enzyme/Protease,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{5280961}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 26  0  0  0  0            999 V2000
    7.5987    1.1254    0.0000 H   0  3
    5.0987    1.1254    0.0000 Cl  0  5
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8978   -0.7496    0.0000 C   0  0
   -5.1981   -1.4975    0.0000 C   0  0
   -6.4959   -0.7455    0.0000 C   0  0
   -6.4936    0.7545    0.0000 C   0  0
   -5.1933    1.5025    0.0000 C   0  0
   -3.8955    0.7504    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  3  4  2  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
  6 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28253

> <plate>
Kinase v5-1

> <well>
A16

> <supplier_cmpd_name>
LY 294002 hydrochloride

> <ctcr_id>
1436

> <supplier_cmpd_id>
1130

> <smiles>
[H+].[Cl-].O=C1C=C(Oc2c1cccc2c3ccccc3)N4CCOCC4

> <pd_targets>
{BLM,LMNA,GMNN,ALDH1A1,SMN1,PMP22,KDM4E,PIK3CD,PIK3CB,PRKDC,PIK3CA,MTOR,PIK3CG,PLK1,PIK3R1,PIK3R2,PIK3C2B,PIM3,CYP2D6,CYP1A2,PIM1,NFKB1,CYP2C19,CYP3A4,PLK3,PDE2A,TSHR,BRD3,PLK2,HIF1A,ALOX15,THPO,CYP2C
9,BRD4,BRD2,PIK3C2A,HSD17B10,CDK8,PDE3A,PDE3B,GSK3B,CSNK2A1,CSNK2A2,CSNK2B,HTR2B,PDE5A,HTR2A,CACNA1C,CACNB2,HTR2C}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein","Unclassified protein","Epigenetic regulator","Other cytosolic protein","Membrane receptor","Transcription factor","Ion channel",Oxidoreductase,Reader,Eraser,Transferas
e,Kinase,Protease,"Cytochrome P450",Phosphodiesterase,"Family A G protein-coupled receptor","Voltage-gated ion channel","Methyl-lysine/arginine binding protein","Lysine demethylase","Protein Kinase","
Cysteine protease","Cytochrome P450 family 2","Cytochrome P450 family 1","Cytochrome P450 family 3","Phosphodiesterase 2","Peptide receptor (family A GPCR)",Bromodomain,"Phosphodiesterase 3","Small mo
lecule receptor (family A GPCR)","Phosphodiesterase 5","Voltage-gated calcium channel","Tudor domain","Jumonji domain-containing","Atypical protein kinase group","Other protein kinase group","CAMK pro
tein kinase group","Cysteine protease CA clan","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Cytochrome P450 family 2C","Cytochrome P450 family 3A","Phosphodiesterase 2A","Glycohormone rece
ptor","CMGC protein kinase group","Phosphodiesterase 3A","Monoamine receptor","Phosphodiesterase 5A","Atypical protein kinase PIKK family","Other protein kinase PLK family","CAMK protein kinase PIM fa
mily","Cysteine protease C1A family","Cytochrome P450 2D6","Cytochrome P450 1A1","Cytochrome P450 2C19","Cytochrome P450 3A4","Cytochrome P450 2C9","CMGC protein kinase CDK family","CMGC protein kinas
e GSK family","Other protein kinase CK2 family","Serotonin receptor","Atypical protein kinase FRAP subfamily","Other protein kinase PLK2","CMGC protein kinase CDK8 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Chromatin modifying enzymes","Kinases (EC 2.7.x.x)","Catalytic receptors","Glycerophospholipid turnover","Cytochrome P450","Cyclic nucleotide turnover/signalling","G protein-couple
d receptors","Eicosanoid turnover","1.14.11.- Histone demethylases","Lipid modifying kinases",Atypical,"Receptor kinases","Phosphatidylinositol kinases","CAMK: Calcium/calmodulin-dependent protein kin
ases","CYP2 family: drug metabolising subset","CYP1 family","CYP3 family",Phosphodiesterases,3',"5'-cyclic nucleotide (PDEs)","Glycoprotein hormone receptors","Enzymatic bromodomain-containing protein
s",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","5-Hydroxytryptamine receptors",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinase
s (PIKK) family","Other protein kinases","Phosphatidylinositol-4-phosphate 3-kinase family","PIM family","Bromodomain kinase (BRDK) family","Cyclin-dependent kinase (CDK) family","Glycogen synthase ki
nase (GSK) family","Other PIKK family kinases","FRAP subfamily","Polo-like kinase (PLK) family","CDK8 subfamily","GSK subfamily"}

> <pathway_reactome>
{"DNA Repair","Cell Cycle",Metabolism,"Metabolism of RNA","Developmental Biology","Immune System","Signal Transduction",Disease,"Gene expression (Transcription)",Hemostasis,"Cellular responses to exte
rnal stimuli","DNA Double-Strand Break Repair",Mitotic,"Biological oxidations","Metabolism of non-coding RNA","Nervous system development","Cytokine Signaling in Immune system","Signaling by Receptor 
Tyrosine Kinases","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Metabolism of lipids","Platelet homeostas
is","Infectious disease","Cellular responses to stress","Platelet activation","signaling and aggregation","Metabolism of amino acids and derivatives","Signaling by GPCR","Homology Directed Repair","M 
Phase","Mitotic G1 phase and G1/S transition","Phase I - Functionalization of compounds","snRNP Assembly","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Signaling by Interleukins","
Signaling by Insulin receptor","Cytosolic sensors of pathogen-associated DNA","Signaling by FGFR in disease","Generic Transcription Pathway","Phospholipid metabolism","Mitotic G2-G2/M phases","FLT3 si
gnaling in disease","Biosynthesis of specialized proresolving mediators (SPMs)","Nitric oxide stimulates guanylate cyclase","Leishmania infection","Cellular response to hypoxia","Platelet Aggregation 
(Plug Formation)","SARS-CoV Infections","Branched-chain amino acid catabolism","Signaling by NOTCH1 in Cancer","GPCR ligand binding","HDR through Homologous Recombination (HRR) or Single Strand Anneal
ing (SSA)","Mitotic Metaphase and Anaphase","G1/S Transition","Ethanol oxidation",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","STING mediated induction of 
host immune responses","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","PI Metabolism","G2/M Transition","Cytochrome P450 - arranged by substrate type","Signaling by FLT3 ITD and 
TKD mutants","Interleukin-1 family signaling","Biosynthesis of DHA-derived SPMs","cGMP effects","Leishmania parasite growth and survival","Oxygen-dependent proline hydroxylation of Hypoxia-inducible F
actor Alpha","Biosynthesis of DPA-derived SPMs","Potential therapeutics for SARS","Transcriptional regulation by RUNX3","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","SARS-CoV-1 Infection","C
lass A/1 (Rhodopsin-like receptors)","HDR through Homologous Recombination (HRR)","Mitotic Anaphase","Activation of the pre-replicative complex","Interleukin receptor SHC signaling","IRS-mediated sign
alling","IRF3-mediated induction of type I IFN","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Synthesis of PIPs at the plasma membrane","Centrosome maturation",Xenobiotics,"STAT5 a
ctivation downstream of FLT3 ITD mutants","Interleukin-1 signaling","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","Biosynthesis of DPAn-3 SPMs","RUNX3
 regulates p14-ARF","Synthesis of PIPs at the early endosome membrane","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","SARS-CoV-1 Genome Replication and Transcription","Amine ligand-binding
 receptors","Homologous DNA Pairing and Strand Exchange","Nuclear Envelope (NE) Reassembly","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation"
,"Loss of proteins required for interphase microtubule organization from the centrosome","CYP2E1 reactions","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent 
MAPK1/3 activation","Biosynthesis of maresin-like SPMs","Regulation of TP53 Activity through Phosphorylation","ADORA2B mediated anti-inflammatory cytokines production","CD163 mediating an anti-inflamm
atory response","Biosynthesis of DPAn-3-derived protectins and resolvins","Replication of the SARS-CoV-1 genome","Serotonin receptors","Presynaptic phase of homologous DNA pairing and strand exchange"
,"Initiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{AKT1,CHEK1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,MTOR,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PLK1,PRKCA,PRKDC,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"DNA dependent protein kinase inhibitor","mTOR inhibitor","phosphodiesterase inhibitor","PI3K inhibitor","PLK inhibitor"}

> <synonyms>
{"LY-294,002 hydrochloride","LY294,002 hydrochloride",934389-88-5,934389885,"LY 294002 HYDROCHLORIDE","LY-294002 hydrochloride","LY294002 hydrochloride","LY294002 (hydrochloride)","2-(4-Morpholinyl)-8
-phenyl-4H-1-benzopyran-4-one hydrochloride","2(4Morpholinyl)8phenyl4H1benzopyran4one hydrochloride",2-morpholin-4-yl-8-phenylchromen-4-one;hydroch,2morpholin4yl8phenylchromen4one;hydroch,1130,"LY 294
002 hydrochloride"}

> <pdid>
PD007784

> <targets>
{PI3K}

> <classes>
{}

> <pubchem_cids>
{11957589}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  0  0            999 V2000
    3.8964    0.7545    0.0000 N   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2029   -2.9940    0.0000 C   0  0
    5.2056   -4.4940    0.0000 N   0  0
    6.4990   -0.7409    0.0000 C   0  0
    6.4964    0.7599    0.0000 C   0  0
    6.4938    2.2599    0.0000 N   0  0
    7.8003   -1.4887    0.0000 C   0  0
    7.8029   -2.9887    0.0000 N   0  0
    9.0990   -0.7364    0.0000 S   0  0
   10.4003   -1.4841    0.0000 C   0  0
   10.4004   -2.9842    0.0000 C   0  0
   11.6994   -3.7342    0.0000 C   0  0
   12.9985   -2.9841    0.0000 C   0  0
   12.9984   -1.4841    0.0000 C   0  0
   11.6994   -0.7342    0.0000 C   0  0
   11.6994    0.7658    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
  2 11  2  0
 11 12  1  0
 12 13  3  0
 11 14  1  0
 14 15  1  0
 15 16  3  0
 14 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 25 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28254

> <plate>
Kinase v5-1

> <well>
A18

> <supplier_cmpd_name>
U0126

> <ctcr_id>
7667

> <supplier_cmpd_id>
1144

> <smiles>
N\C(Sc1ccccc1N)=C(C#N)/C(C#N)=C(\N)Sc2ccccc2N

> <pd_targets>
{MAP2K1,KMT2A,MEN1,MAPT,FTL,MAPK1,BLM,GMNN,GAA,LMNA,HPGD,NPSR1,ALDH1A1,MTOR,FFP,MAPKAPK5,BRAF,MAP2K2,MDH,MAPK14,AKT1,RAF1,CYP2C19,RORC,LEF,CHRM1,HSD17B10,EGFR,CYP2D6,CYP1A2,ALOX15,KDM4E,HIF1A,ALOX12,C
YP3A4,THPO}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Unclassified protein","Other nuclear protein","Membrane receptor",Kinase,Reader,Hydrolase,"Family A G protein-coupled receptor",Oxidoreductase
,Transferase,"Protein Kinase",Bromodomain,"Peptide receptor (family A GPCR)","STE protein kinase group","CMGC protein kinase group","Short peptide receptor (family A GPCR)","Atypical protein kinase gr
oup","CAMK protein kinase group","TKL protein kinase group","AGC protein kinase group","STE protein kinase STE7 family","CMGC protein kinase MAPK family","Neuropeptide receptor","Atypical protein kina
se PIKK family","CAMK protein kinase MAPKAPK family","TKL protein kinase RAF family","AGC protein kinase AKT family","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","CAMK protein k
inase MAPKAPK subfamily","CMGC protein kinase p38 subfamily","Transcription factor","Cytochrome P450","Nuclear receptor",Protease,Eraser,"Cytochrome P450 family 2","Nuclear hormone receptor subfamily 
1","Metallo protease","Small molecule receptor (family A GPCR)","Cytochrome P450 family 1","Lysine demethylase","Cytochrome P450 family 3","Cysteine protease","Cytochrome P450 family 2C","Nuclear horm
one receptor subfamily 1 group F","Metallo protease MAE clan","Monoamine receptor","TK protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Jumonji domain-containing","Cytoch
rome P450 family 3A","Cysteine protease CA clan","Cytochrome P450 2C19","Nuclear hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Acetylcholine receptor","Tyrosine protein
 kinase EGFR family","Cytochrome P450 2D6","Cytochrome P450 1A1","Cytochrome P450 3A4","Cysteine protease C1A family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","3.2.1.- Glycosidases","Eicosanoid turnover","G protein-coupled receptors","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 k
inases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglandin synthases","Neuropeptide S receptor",Atypical,"CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","AGC: Conta
ining PKA",PKG,"PKC families","STE7 family","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","MAPK-Activated Protein Kinase (MAPKAPK) f
amily","TKL: Tyrosine kinase-like","Akt (Protein kinase B","PKB) family","ERK subfamily","FRAP subfamily","MAPKAPK subfamily","RAF family","p38 subfamily","Cytochrome P450","Nuclear hormone receptors"
,"Chromatin modifying enzymes","CYP2 family: drug metabolising subset","1F. Retinoic acid-related orphans","Acetylcholine receptors (muscarinic)","CYP1 family",Lipoxygenases,"1.14.11.- Histone demethy
lases","CYP3 family","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System","Vesicle-mediated transport","Immune System","DNA Repair","Cell Cycle",Disease,Metabolism,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kin
ases","Transmission across Chemical Synapses","Membrane Trafficking","Innate Immune System","DNA Double-Strand Break Repair",Mitotic,"Diseases of metabolism","Metabolism of lipids","Infectious disease
","Biological oxidations","RNA Polymerase II Transcription","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Toll-like Rece
ptor Cascades","Homology Directed Repair","Mitotic G1 phase and G1/S transition","Diseases of carbohydrate metabolism","M Phase","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania
 infection","Phase I - Functionalization of compounds","Generic Transcription Pathway","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biog
enesis","Toll Like Receptor 5 (TLR5) Cascade","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","G1/S Transition","Glycogen storage diseases","Mitotic Metaphase and Anaphas
e","Biosynthesis of DHA-derived SPMs","Leishmania parasite growth and survival","Ethanol oxidation","Transcriptional Regulation by TP53","Signalling to ERKs","Post NMDA receptor activation events","My
D88 cascade initiated on plasma membrane","HDR through Homologous Recombination (HRR)","Activation of the pre-replicative complex","Glycogen storage disease type II (GAA)","Mitotic Anaphase","Biosynth
esis of D-series resolvins","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of TP53 Activity","Prolonged ERK activation events","Activation of AMPK downstream of NMDAR
s","MAP kinase activation","Homologous DNA Pairing and Strand Exchange","Nuclear Envelope (NE) Reassembly","ADORA2B mediated anti-inflammatory cytokines production","Regulation of TP53 Expression and 
Degradation","Regulation of TP53 Activity through Phosphorylation","Frs2-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","Presynaptic phase of homologous DNA pairing and st
rand exchange","Initiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","ARMS-mediated activation","ERK/MAPK targets","Activation of the AP-1 family of transcription factors"
,"ERKs are inactivated","Cellular responses to external stimuli",Hemostasis,"Signaling by GPCR","Metabolism of amino acids and derivatives","Cellular responses to stress","Platelet activation","signal
ing and aggregation","Uptake and actions of bacterial toxins","GPCR ligand binding","Branched-chain amino acid catabolism","GPCR downstream signalling","Cellular response to hypoxia","Platelet Aggrega
tion (Plug Formation)","Cytochrome P450 - arranged by substrate type","Transcriptional regulation by RUNX3","Uptake and function of anthrax toxins","Class A/1 (Rhodopsin-like receptors)","G alpha (q) 
signalling events","Biosynthesis of DPA-derived SPMs","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha",Xenobiotics,"RUNX3 Regulates Immune Response and Cell Migration","Amine
 ligand-binding receptors","Gastrin-CREB signalling pathway via PKC and MAPK","Biosynthesis of DPAn-3 SPMs","Biosynthesis of maresins","CYP2E1 reactions","Muscarinic acetylcholine receptors","EGFR Tra
nsactivation by Gastrin","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of DPAn-3-derived protectins and resolvins","Biosynthesis of DPAn-3-derived maresins","Biosynt
hesis of maresin-like SPMs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{U0126,109511-58-2,109511582,"109511 58 2",U-0126,"U 0126","1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene","1,4Diamino2,3dicyano1,4bis(oaminophenylmercapto)butadiene","1,4 Diamino 2,
3 dicyano 1,4 bis(o aminophenylmercapto)butadiene",EI-282,1144}

> <pdid>
PD014850

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{3006531}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    7.7962   -1.5128    0.0000 C   0  0
    6.4994   -0.7589    0.0000 O   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    3.9015    0.7475    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  7 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28255

> <plate>
Kinase v5-1

> <well>
A20

> <supplier_cmpd_name>
PD 98059

> <ctcr_id>
4311

> <supplier_cmpd_id>
1213

> <smiles>
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

> <pd_targets>
{HPGD,CYP3A4,CYP1A2,MAPK1,PTGS1,SMN1,TSHR,MAPT,CYP2C19,PYK,MAP2K1,ALDH1A1,PMP22,PKM,ALOX15,THPO,TP53,CYP2D6,CYP2C9,KMT2A,MEN1,LEF,BLM,NPC1,CHRM1,RAF1,RAB9A,MAP2K2,GMNN,RORC}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Membrane receptor","Other cytosolic protein","Unclassified protein","Transcription factor",Transporter,"Cytochrome P450",Kinase,Oxidoreductase,Reader,"Family A G protei
n-coupled receptor",Transferase,Protease,Hydrolase,"Nuclear receptor","Cytochrome P450 family 3","Cytochrome P450 family 1","Protein Kinase","Methyl-lysine/arginine binding protein","Peptide receptor 
(family A GPCR)","Cytochrome P450 family 2",Bromodomain,"Metallo protease","Small molecule receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3A","Cytochrome P450
 family 1A","CMGC protein kinase group","Tudor domain","Glycohormone receptor","Cytochrome P450 family 2C","STE protein kinase group","Cytochrome P450 family 2D","Metallo protease MAE clan","Monoamine
 receptor","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 3A4","Cytochrome P450 1A1","CMGC protein kinase MAPK family","Cytochrome P450 2C19","STE protein kinase STE7 family","Cytochr
ome P450 2D6","Cytochrome P450 2C9","Metallo protease M34 family","Acetylcholine receptor","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Eicosanoid turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","G protein-coupled receptors","2.7.1.40 Pyruvate kinases","SLC superfamily of solute carriers","Nuclear h
ormone receptors","Prostaglandin synthases","CYP3 family","CYP1 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Cyclooxygenase,"Glycoprotein hormone receptors","CYP2 family: drug metabolising 
subset","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Lipoxygenases,"SLC65 NPC-type cholesterol transporters","Acetylcholine receptors (muscarinic)","1F. Retinoic acid-related o
rphans","Mitogen-activated protein kinases (MAP kinases)","STE7 family","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Immune System","Metabolism of RNA",Disease,"Neuronal System","Signal Transduction","Developmental Biology",Hemostasis,"Cell Cycle","DNA Repair","Transport of small molecules","Gene expres
sion (Transcription)","Metabolism of lipids","Biological oxidations","Innate Immune System","Metabolism of non-coding RNA","Infectious disease","Transmission across Chemical Synapses","Signaling by Re
ceptor Tyrosine Kinases","Nervous system development","Metabolism of carbohydrates","Platelet activation","signaling and aggregation","Cell Cycle Checkpoints","DNA Double-Strand Break Repair","Plasma 
lipoprotein assembly",remodeling,"and clearance","Signaling by GPCR","Signaling by Rho GTPases",Mitotic,"RNA Polymerase II Transcription","Biosynthesis of specialized proresolving mediators (SPMs)","P
hase I - Functionalization of compounds","Toll-like Receptor Cascades","Fatty acid metabolism","snRNP Assembly","Leishmania infection","Neurotransmitter receptors and postsynaptic signal transmission"
,"Signaling by NTRKs","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Glucose metabolism","Platelet Aggregation (Plug Formation)","G1/S DNA Damage Checkpoints","Uptake and actions of
 bacterial toxins","Homology Directed Repair","Plasma lipoprotein clearance","GPCR ligand binding","Rho GTPase cycle","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Biosynthes
is of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Toll Like Receptor 5 (TLR5) Cascade","Arachidonic acid metabolism","Leishmania parasite growth and survival","Activation of NMDA
 receptors and postsynaptic events","Signaling by NTRK1 (TRKA)","Ethanol oxidation",Glycolysis,"Biosynthesis of DPA-derived SPMs","p53-Dependent G1/S DNA damage checkpoint","Uptake and function of ant
hrax toxins","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","LDL clearance","Class A/1 (Rhodopsin-like receptors)","RHOBTB GTPase Cycle","G1/S Transition","Transcription
al regulation by RUNX3","Biosynthesis of D-series resolvins","Biosynthesis of maresins",Xenobiotics,"MyD88 cascade initiated on plasma membrane","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
","Anti-inflammatory response favouring Leishmania parasite infection","Post NMDA receptor activation events","Signalling to ERKs","Biosynthesis of DPAn-3 SPMs","p53-Dependent G1 DNA Damage Response",
"HDR through Homologous Recombination (HRR)","Amine ligand-binding receptors","RHOBTB3 ATPase cycle","Activation of the pre-replicative complex","RUNX3 Regulates Immune Response and Cell Migration","B
iosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP kinase activation","ADORA2B mediated anti-inflammatory cytokines production","Activation of AM
PK downstream of NMDARs","CYP2E1 reactions","Prolonged ERK activation events","Biosynthesis of DPAn-3-derived protectins and resolvins","Stabilization of p53","Homologous DNA Pairing and Strand Exchan
ge","Muscarinic acetylcholine receptors","MAPK targets/ Nuclear events mediated by MAP kinases","Frs2-mediated activation","Autodegradation of the E3 ubiquitin ligase COP1","Presynaptic phase of homol
ogous DNA pairing and strand exchange","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,CHEK1,GSK3B,LCK,MAP2K1,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,RAF1,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{167869-21-8,167869218,PD98059,"PD 98059",2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one,2(2amino3methoxyphenyl)4Hchromen4one,PD-98059,"PD 98,059",2-(2-amino-3-methoxyphenyl)chromen-4-one,2(2amino3metho
xyphenyl)chromen4one,2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one,2(2Amino3methoxyphenyl)4H1benzopyran4one,2'-AMINO-3'-METHOXYFLAVONE,2'AMINO3'METHOXYFLAVONE,PD-098059,PD098059,4H-1-Benzopyran-4-
one,4H1Benzopyran4one,T2623,"EMD 513000",S1177,1213,EI-360,513000}

> <pdid>
PD002681

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{4713}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  1  0            999 V2000
    2.5953   -3.0022    0.0000 C   0  0
    2.5978   -1.5022    0.0000 C   0  0  1  0  0  0
    3.8983   -0.7547    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -7.7985    2.9932    0.0000 N   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
  2  1  1  6
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  7 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28256

> <plate>
Kinase v5-1

> <well>
A22

> <supplier_cmpd_name>
Y-27632 dihydrochloride

> <ctcr_id>
4369

> <supplier_cmpd_id>
1254

> <smiles>
C[C@@H](N)C1CCC(CC1)C(=O)Nc2ccncc2

> <pd_targets>
{PKN2,ROCK1,ROCK2,KCNH2,PRKCE,LMNA,CYP3A4,ALOX15,RPS6KA5,CCL2,PRKCQ,CDK5,CDK8,PRKD3,LTK,STK3,CLK4,CDC42BPA,PRKCD,CDK2,BRSK1,PRKG2,PRKX,LRRK2,CHUK,CDK1}

> <pathway_gtopdb>
{Enzyme,"Ion channel","Other nuclear protein","Membrane receptor",Kinase,"Voltage-gated ion channel","Cytochrome P450",Oxidoreductase,"Family A G protein-coupled receptor","Protein Kinase","Potassium 
channels","Cytochrome P450 family 3","Peptide receptor (family A GPCR)","AGC protein kinase group","Voltage-gated potassium channel","Cytochrome P450 family 3A","Chemokine receptor","CMGC protein kina
se group","CAMK protein kinase group","TK protein kinase group","STE protein kinase group","TKL protein kinase group","Other protein kinase group","AGC protein kinase PKN family","AGC protein kinase D
MPK family","AGC protein kinase PKC family","Cytochrome P450 3A4","AGC protein kinase RSK family","CC chemokine receptor","CMGC protein kinase CDK family","CAMK protein kinase PKD family","Tyrosine pr
otein kinase Alk family","STE protein kinase STE20 family","CMGC protein kinase CLK family","CAMK protein kinase CAMK1 family","AGC protein kinase PKG family","AGC protein kinase PKA family","TKL prot
ein kinase LRRK family","Other protein kinase IKK family","AGC protein kinase ROCK subfamily","AGC protein kinase PKC eta subfamily","AGC protein kinase MSK subfamily","AGC protein kinase PKC delta su
bfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK8 subfamily","STE protein kinase MST subfamily","AGC protein kinase GEK subfamily","CMGC protein kinase CDC2 subfamily","CAMK prot
ein kinase BRSK subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels",Receptors,"Kinases (EC 2.7.x.x)","Voltage-gated ion channels","Cytochrome P450","Eicosanoid turnover","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","Potassium 
channels","CYP3 family",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","STE: Homologs of yeast Sterile 7","Steril
e 11","Sterile 20 kinases","Protein kinase N (PKN) family","DMPK family","Voltage-gated potassium channels","Protein kinase C (PKC) family","RSK family","Cyclin-dependent kinase (CDK) family","Protein
 kinase D (PKD) family","TK: Tyrosine kinase","STE20 family","CLK family","CAMK-like (CAMKL) family","Protein kinase G (PKG) family","Protein kinase A (PKA) family","TKL: Tyrosine kinase-like","Other 
protein kinases","Rho kinase","Eta subfamily","MSK subfamily","Delta subfamily","CDK5 subfamily","CDK8 subfamily","Receptor tyrosine kinases (RTKs)","MST subfamily","GEK subfamily","CDK1 subfamily","B
RSK subfamily","Leucine-rich repeat kinase (LRRK) family","IKK family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Muscle contraction","Immune System","Cell Cycle",Metabolism,"Gene expression (Transcription)",Disease,"Signaling by Rho GTPases","Nervous system develop
ment","Cardiac conduction","Innate Immune System",Mitotic,"Metabolism of lipids","Signaling by GPCR","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and s
econd messengers","Signaling by Hippo","Intracellular signaling by second messengers","MAPK family signaling cascades","Infectious disease","Signaling by Non-Receptor Tyrosine Kinases","RHO GTPase Eff
ectors","Axon guidance","Phase 3 - rapid repolarisation","Fcgamma receptor (FCGR) dependent phagocytosis","M Phase","Biosynthesis of specialized proresolving mediators (SPMs)","Toll-like Receptor Casc
ades","GPCR ligand binding","GPCR downstream signalling","Generic Transcription Pathway","Signaling by NOTCH1 in Cancer","Sphingolipid metabolism","DAG and IP3 signaling","MAPK1/MAPK3 signaling","Leis
hmania infection","Signaling by PTK6","Regulation of mitotic cell cycle","RHO GTPases activate PKNs","Semaphorin interactions","Role of phospholipids in phagocytosis","Mitotic Metaphase and Anaphase",
"Biosynthesis of DHA-derived SPMs","Biosynthesis of DPA-derived SPMs","Toll Like Receptor 5 (TLR5) Cascade","Class A/1 (Rhodopsin-like receptors)","G alpha (i) signalling events","Transcriptional Regu
lation by TP53","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Sphingolipid de novo biosynthesis","CaM pathway","RAF/MAP kinase cascade","Leishmania parasite growth and survival","PTK6 promot
es HIF1A stabilization","Toll Like Receptor 4 (TLR4) Cascade","APC/C-mediated degradation of cell cycle proteins","Sema4D in semaphorin signaling","Mitotic Anaphase","Biosynthesis of maresins","Biosyn
thesis of DPAn-3 SPMs","MyD88 cascade initiated on plasma membrane","Peptide ligand-binding receptors","Visual phototransduction","Regulation of TP53 Activity","Constitutive Signaling by NOTCH1 HD+PES
T Domain Mutants","Calmodulin induced events","RAS processing","Anti-inflammatory response favouring Leishmania parasite infection","MyD88-independent TLR4 cascade","Activation of APC/C and APC/C:Cdc2
0 mediated degradation of mitotic proteins","Sema4D induced cell migration and growth-cone collapse","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","Biosynthesis of DPAn-3-deri
ved protectins and resolvins","MAP kinase activation","Chemokine receptors bind chemokines","The phototransduction cascade","Regulation of TP53 Activity through Phosphorylation","Regulation of TP53 Ex
pression and Degradation","ADORA2B mediated anti-inflammatory cytokines production","TRIF(TICAM1)-mediated TLR4 signaling","APC/C:Cdc20 mediated degradation of mitotic proteins","Initiation of Nuclear
 Envelope (NE) Reformation","MAPK targets/ Nuclear events mediated by MAP kinases",Inactivation,"recovery and regulation of the phototransduction cascade","Regulation of TP53 Degradation","IKK complex
 recruitment mediated by RIP1","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","CREB phosphorylation","Cdc20:Phospho-APC/C mediated degradatio
n of Cyclin A"}

> <broad_targets>
{PKIA,PKN2,PRKACA,PRKCE,ROCK1,ROCK2}

> <broad_moa>
{"rho associated kinase inhibitor"}

> <synonyms>
{2763,NCGC00092276-05,NCGC0009227605,NCGC00092276-06,NCGC0009227606,y-27632,y27632,146986-50-7,146986507,"Y-27632 dihydrochloride","Y27632 dihydrochloride",Y27632,"Y 27632",UNII-0X370ROP6H,UNII0X370RO
P6H,"cyclohexanecarboxamide, 4-((1R)-1-aminoethyl)-N-4-pyridinyl-, trans-","cyclohexanecarboxamide, 4((1R)1aminoethyl)N4pyridinyl, trans",4-((1R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamid
e,4((1R)1aminoethyl)N(pyridin4yl)cyclohexane1carboxamide,Y-27632}

> <pdid>
PD004560

> <targets>
{Autophagy,ROCK,p160ROCK,PRK2}

> <classes>
{}

> <pubchem_cids>
{448042}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 N   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.8193    4.6606    0.0000 C   0  0
   -4.0353    5.9336    0.0000 C   0  0
   -4.7489    7.2530    0.0000 C   0  0
   -6.2483    7.2947    0.0000 N   0  0
   -7.0341    6.0170    0.0000 C   0  0
   -6.3205    4.6976    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -6.4469    1.8311    0.0000 C   0  0
   -7.4153    2.9701    0.0000 C   0  0
   -8.8906    2.6991    0.0000 C   0  0
   -9.3937    1.2860    0.0000 C   0  0
  -10.8690    1.0150    0.0000 F   0  0
   -8.4213    0.1438    0.0000 C   0  0
   -6.9460    0.4147    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 10 17  2  0
 17 18  1  0
 18  8  2  0
 17 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28257

> <plate>
Kinase v5-1

> <well>
C04

> <supplier_cmpd_name>
SB 202190

> <ctcr_id>
90

> <supplier_cmpd_id>
1264

> <smiles>
Oc1ccc(cc1)c2[nH]c(c3ccncc3)c(n2)c4ccc(F)cc4

> <pd_targets>
{EGFR,MAPK11,MAPK14,ALDH1A1,HPGD,CYP2C9,CSNK1A1,MAPK10,RIPK2,TNIK,LEF,AMPC,BRD4,BRDT,TUBA1A,PRKACA,MAPK8,BRAF,CIT,CSNK1E,MAPK12,RPS6KA1,MAPK1,ACVR1B,GSK3B,MAPK9,RAF1,GAK,PRKACB,MAP2K2,ACVR2B,COQ8B,TSH
R,ROS1,HSD17B10,KDM4E,FRK,STK36,PTK6,MAPT,BLM,TTK,CYP2C19,THPO,CDC42BPG,EPHA7,RPS6KA6,STK32B,HTR2A,ERBB4,CSNK1A1L,NTRK3,CYP2D6,CYP3A4,LATS2,IGF1R,DDR1,DDR2,SLK,NLK,CSNK1D,NTRK2,GMNN,CYP1A2,TTBK1,LMNA,
NFKB1,EPHA6,MAPK13,CDC42BPB,TTBK2,ALOX5,CLK4,PRKD3,NFO,PMP22,ALOX15,MAP4K4,GCGR,TYR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Structural protein","Membrane receptor","Other cytosolic protein","Unclassified protein","Other nuclear protein",Kinase,Oxidoreductase,"Cytochrome P450",Protease,Hydrol
ase,Reader,"Family A G protein-coupled receptor",Eraser,"Family B G protein-coupled receptor","Protein Kinase","Cytochrome P450 family 2","Metallo protease",Bromodomain,"Peptide receptor (family A GPC
R)","Lysine demethylase","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 1","Peptide receptor (family B GPCR)","TK protein kinase group","CMGC protein kina
se group","Cytochrome P450 family 2C","CK1 protein kinase group","TKL protein kinase group","STE protein kinase group","Metallo protease MAE clan","AGC protein kinase group","Other protein kinase grou
p","Atypical protein kinase group","Glycohormone receptor","Jumonji domain-containing","Monoamine receptor","Cytochrome P450 family 2D","Cytochrome P450 family 3A","Cytochrome P450 family 1A","CAMK pr
otein kinase group","Glucagon-like receptor","Tyrosine protein kinase EGFR family","CMGC protein kinase MAPK family","Cytochrome P450 2C9","CK1 protein kinase CK1 family","TKL protein kinase RIPK fami
ly","STE protein kinase STE20 family","Metallo protease M34 family","AGC protein kinase PKA family","TKL protein kinase RAF family","AGC protein kinase DMPK family","AGC protein kinase RSK family","TK
L protein kinase STKR family","CMGC protein kinase GSK family","Other protein kinase NAK family","STE protein kinase STE7 family","Atypical protein kinase ABC1 family","Tyrosine protein kinase Sev fam
ily","Tyrosine protein kinase Src family","Other protein kinase ULK family","Other protein kinase TTK family","Cytochrome P450 2C19","Tyrosine protein kinase Eph family","AGC protein kinase YANK famil
y","Serotonin receptor","Tyrosine protein kinase Trk family","Cytochrome P450 2D6","Cytochrome P450 3A4","AGC protein kinase NDR family","Tyrosine protein kinase InsR family","Tyrosine protein kinase 
DDR family","Cytochrome P450 1A1","CMGC protein kinase CLK family","CAMK protein kinase PKD family","Glucagon receptor","CMGC protein kinase p38 subfamily","CMGC protein kinase JNK subfamily","STE pro
tein kinase MSN subfamily","AGC protein kinase CRIK subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase ERK1","TKL protein kinase STKR Type 1 subfamily","TKL protein kinase STKR Type 2 
subfamily","Atypical protein kinase ABC1-A subfamily","AGC protein kinase GEK subfamily","CK1 protein kinase CK1-a","STE protein kinase SLK subfamily","CMGC protein kinase nmo subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Eicosanoid turnover","Cytochrome P450","Chromatin modifying enzymes","Bromodomain-containing proteins",Tubulins
,"G protein-coupled receptors","1.-.-.- Oxidoreductases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglandin synthases","CYP2 family: drug metabolising subset","CK1: Case
in kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Enzymatic bromodomain-containing proteins","Non-enzymatic BRD containing proteins","AGC: Containing PKA",PKG,"PKC fam
ilies",Atypical,"Glycoprotein hormone receptors","1.14.11.- Histone demethylases","5-Hydroxytryptamine receptors","CYP3 family","CYP1 family",Lipoxygenases,"CAMK: Calcium/calmodulin-dependent protein 
kinases","Glucagon receptor family","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Casein kinase 1 (CK1) family","TKL: Tyrosine kinase-like","STE20 family","Bromodomain kinas
e (BRDK) family","Protein kinase A (PKA) family","DMPK family","RSK family","Glycogen synthase kinase (GSK) family","Other protein kinases","STE7 family","ABC1 family","YANK family","NDR family","Tau 
tubulin kinase (TTBK) family","CLK family","Protein kinase D (PKD) family","Receptor tyrosine kinases (RTKs)","p38 subfamily","JNK subfamily","Receptor interacting protein kinase (RIPK) family","MSN s
ubfamily","RAF family","Other DMPK family kinases","RSK subfamily","ERK subfamily","Receptor serine/threonine kinase (RSTK) family","GSK subfamily","Numb-associated kinase (NAK) family","ABC1-B subfam
ily","Non-receptor tyrosine kinases (nRTKs)","Unc-51-like kinase (ULK) family","TTK family","GEK subfamily","SLK subfamily","nmo subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family
","Type I receptor serine/threonine kinases","Type II receptor serine/threonine kinases","Type XVII RTKs: ROS receptors","Src family","Type XIII RTKs: Ephrin receptor family","Type VII RTKs: Neurotrop
hin receptor/Trk family","Type II RTKs: Insulin receptor family","Type XVI RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Metabolism,Disease,"Cellular responses to external stimuli","Cell Cycle","Developmental Biology","Vesicle-mediated transport","Neuronal System","DNA Repair",Hemo
stasis,"Extracellular matrix organization","Organelle biogenesis and maintenance","Signaling by GPCR","Innate Immune System","Biological oxidations","Metabolism of lipids","Diseases of signal transduc
tion by growth factor receptors and second messengers","Cellular responses to stress","Infectious disease",Mitotic,"Signaling by Receptor Tyrosine Kinases","Signaling by Rho GTPases","Signaling by NOD
AL","MAPK family signaling cascades","Membrane Trafficking","Intracellular signaling by second messengers","Metabolism of amino acids and derivatives","Transmission across Chemical Synapses","DNA Doub
le-Strand Break Repair","Platelet activation","signaling and aggregation","Nervous system development","Signaling by Hippo","Non-integrin membrane-ECM interactions","Signaling by WNT","Cytokine Signal
ing in Immune system","Cilium Assembly","GPCR downstream signalling","Toll-like Receptor Cascades","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)
","Signaling by WNT in cancer","Cellular Senescence","Uptake and actions of bacterial toxins","SARS-CoV Infections","Mitotic G2-G2/M phases","Signaling by NTRKs","RHO GTPase Effectors","Regulation of 
signaling by NODAL","MAPK1/MAPK3 signaling","trans-Golgi Network Vesicle Budding","DAG and IP3 signaling","Leishmania infection","Branched-chain amino acid catabolism","PIP3 activates AKT signaling","
Mitotic G1 phase and G1/S transition","Neurotransmitter receptors and postsynaptic signal transmission","Homology Directed Repair","Platelet Aggregation (Plug Formation)","Axon guidance","GPCR ligand 
binding","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Beta-catenin independent WNT signaling","M Phase","Signaling by Interleukins","Anchoring of the basal body to the plasma m
embrane","Sphingolipid metabolism","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Melanin biosynthesis","G alpha (q) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Ethano
l oxidation","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Signaling by AMER1 mutants","Oxidative Stress Induced Senescence","Uptake and function of anthrax toxins
","Potential therapeutics for SARS","G2/M Transition","Signaling by NTRK1 (TRKA)","RHO GTPases activate CIT","SARS-CoV-1 Infection","RAF/MAP kinase cascade","Golgi Associated Vesicle Biogenesis","CaM 
pathway","Leishmania parasite growth and survival","PTEN Regulation","G1 Phase","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Anne
aling (SSA)","EPH-Ephrin signaling","Class A/1 (Rhodopsin-like receptors)","Signaling by NTRK3 (TRKC)","IGF1R signaling cascade","Ca2+ pathway","G1/S Transition","Mitotic Metaphase and Anaphase","Inte
rleukin-1 family signaling","Biosynthesis of DPA-derived SPMs","Sphingolipid de novo biosynthesis","Gastrin-CREB signalling pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Bios
ynthesis of D-series resolvins",Xenobiotics,"Truncations of AMER1 destabilize the destruction complex","Centrosome maturation","Signalling to ERKs","SARS-CoV-1 Genome Replication and Transcription","N
egative regulation of MAPK pathway","Calmodulin induced events","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of PTEN stability and activity","Cyclin D associated ev
ents in G1","Post NMDA receptor activation events","HDR through Homologous Recombination (HRR)","EPHA-mediated growth cone collapse","Amine ligand-binding receptors","Activated NTRK3 signals through P
I3K","Biosynthesis of maresins","IRS-related events triggered by IGF1R","Activation of TRKA receptors","Activation of the pre-replicative complex","Mitotic Anaphase","Interleukin-1 signaling","Biosynt
hesis of DPAn-3 SPMs","EGFR Transactivation by Gastrin","MAP kinase activation","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","Prolonged ER
K activation events","Signalling to RAS","Replication of the SARS-CoV-1 genome","Negative feedback regulation of MAPK pathway","PKA-mediated phosphorylation of CREB","ADORA2B mediated anti-inflammator
y cytokines production","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Serot
onin receptors","Long-term potentiation","Biosynthesis of maresin-like SPMs","NGF-independant TRKA activation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Nuclear Envelope (NE)
 Reassembly","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of DPAn-3-derived 13-series resolvins","Biosynthesis of DPAn-3-derived protectins and resolvins","MAPK targets/ Nuclear events m
ediated by MAP kinases","activated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","ARMS-mediated activation","p38MAPK events","PKA activation","Frs2-mediated activation","Pr
esynaptic phase of homologous DNA pairing and strand exchange","RSK activation","Initiation of Nuclear Envelope (NE) Reformation","Activation of the AP-1 family of transcription factors","CREB phospho
rylation","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,ALOX5,CHEK1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"SB 202190",152121-30-7,152121307,SB-202190,SB202190,FHPI,"SB202190 (FHPI)",4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole,4(4Fluorophenyl)2(4hydroxyphenyl)5(4pyridyl)1Himidazole,U
NII-PVX798P8GI,UNIIPVX798P8GI,4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole,4(4fluorophenyl)2(4hydroxyphenyl)5(4pyridyl)imidazole,CHEBI:79090,4-(4-(4-fluorophenyl),4(4(4fluorophenyl),T
2301,"EMD 559388",1264,EI-294,S1077,559388}

> <pdid>
PD002796

> <targets>
{"p38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{5169}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8933    3.7570    0.0000 C   0  0
    3.8933    5.2571    0.0000 C   0  0
    5.1924    6.0071    0.0000 C   0  0
    6.4914    5.2571    0.0000 C   0  0
    6.4915    3.7571    0.0000 C   0  0
    5.1925    3.0071    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4983    0.7413    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
  6 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 16 21  1  0
 21 22  2  0
 22  2  1  0
 22  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28258

> <plate>
Kinase v5-1

> <well>
C06

> <supplier_cmpd_name>
Olomoucine

> <ctcr_id>
510

> <supplier_cmpd_id>
1284

> <smiles>
Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12

> <pd_targets>
{MAPK3,CDK2,CCNB1,CDK1,CCNE1,CDK5,CDK5R1,GAA,MAPT,CYP3A4,MAPK1,CCNE2,SMN1,ALOX15,CYP1A2,NFKB1,CYP2D6,CCNB2,CCNB3,CCNA1,CCNA2,KDM4E,TDP1,LEF,ALDH1A1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator",Kinase,Hydrolase,"Cytochrome P450",Reader,Oxidoreductase,Eraser,Protease,"Protein Kinase","Cytochrome P450 family 3","Methyl-lysine/arginine bi
nding protein","Cytochrome P450 family 1","Cytochrome P450 family 2","Lysine demethylase","Metallo protease","CMGC protein kinase group","Cytochrome P450 family 3A","Tudor domain","Cytochrome P450 fam
ily 1A","Cytochrome P450 family 2D","Jumonji domain-containing","Metallo protease MAE clan","CMGC protein kinase MAPK family","CMGC protein kinase CDK family","Cytochrome P450 3A4","Cytochrome P450 1A
1","Cytochrome P450 2D6","Metallo protease M34 family","CMGC protein kinase ERK1","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","3.2.1.- Glycosidases","Cytochrome P450","Eicosanoid turnover","Chromatin modifying enzymes","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP3 family",Lipoxygenases
,"CYP1 family","CYP2 family: drug metabolising subset","1.14.11.- Histone demethylases","Mitogen-activated protein kinases (MAP kinases)","Cyclin-dependent kinase (CDK) family","ERK subfamily","CDK1 s
ubfamily","CDK5 subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)","Cell Cycle",Disease,"Neuronal System",Metabolism,"Metabolism of RNA","DNA Repair","Innate Immune System","RNA Polymerase II Transcription",Mitotic,"
Diseases of metabolism","Transmission across Chemical Synapses","Metabolism of lipids","Metabolism of non-coding RNA","Biological oxidations","Cytokine Signaling in Immune system","DNA Double-Strand B
reak Repair","Infectious disease","Toll-like Receptor Cascades","Generic Transcription Pathway","Regulation of mitotic cell cycle","Diseases of carbohydrate metabolism","Neurotransmitter receptors and
 postsynaptic signal transmission","Biosynthesis of specialized proresolving mediators (SPMs)","snRNP Assembly","Phase I - Functionalization of compounds","Signaling by Interleukins","Nonhomologous En
d-Joining (NHEJ)","Uptake and actions of bacterial toxins","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional Regulation by TP53","APC/C-mediated degradation of cell cycle proteins","Glycogen stor
age diseases","Activation of NMDA receptors and postsynaptic events","Biosynthesis of DHA-derived SPMs","Biosynthesis of DPA-derived SPMs","Cytochrome P450 - arranged by substrate type","Interleukin-1
 family signaling","Uptake and function of anthrax toxins","Ethanol oxidation","MyD88 cascade initiated on plasma membrane","Regulation of TP53 Activity","Activation of APC/C and APC/C:Cdc20 mediated 
degradation of mitotic proteins","Glycogen storage disease type II (GAA)","Post NMDA receptor activation events","Biosynthesis of maresins","Biosynthesis of DPAn-3 SPMs",Xenobiotics,"Interleukin-1 sig
naling","MAP kinase activation","Regulation of TP53 Expression and Degradation","APC/C:Cdc20 mediated degradation of mitotic proteins","Activation of AMPK downstream of NMDARs","Biosynthesis of maresi
n-like SPMs","Regulation of TP53 Activity through Phosphorylation","Biosynthesis of DPAn-3-derived protectins and resolvins","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 
(TPL2)-dependent MAPK1/3 activation","CYP2E1 reactions","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins p
rior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CDK1,CDK2,CDK5,MAPK1}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{olomoucine,101622-51-9,101622519,"101622 51 9",Olomucine,4erk,UNII-6A839B2HYS,UNII6A839B2HYS,"UNII 6A839B2HYS",6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine,6(Benzylamino)2(2hydroxyethylamin
o)9methylpurine,"6 (Benzylamino) 2 (2 hydroxy",1284,CC-200,Olomoucine}

> <pdid>
PD002661

> <targets>
{cdk,CDK}

> <classes>
{}

> <pubchem_cids>
{4592}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 17  0  0  0  0            999 V2000
    3.9096   -3.7486    0.0000 C   0  0
    5.2060   -2.9940    0.0000 C   0  0
    6.5074   -3.7399    0.0000 O   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8960   -0.7508    0.0000 C   0  0
    2.5923   -0.0089    0.0000 N   0  0
    6.4959   -0.7356    0.0000 C   0  0
    6.4871    0.7644    0.0000 O   0  0
    7.8003   -1.4780    0.0000 N   0  0
    9.0958   -0.7204    0.0000 C   0  0
    9.0844    0.7796    0.0000 C   0  0
   10.3778    1.5394    0.0000 C   0  0
   10.3664    3.0394    0.0000 Br  0  0
   11.6824    0.7993    0.0000 C   0  0
   11.6938   -0.7006    0.0000 C   0  0
   10.4005   -1.4605    0.0000 C   0  0
   10.4119   -2.9604    0.0000 Br  0  0
  1  2  1  0
  2  3  1  0
  2  4  2  0
  4  5  1  0
  5  6  3  0
  4  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 14 15  1  0
 15 16  2  0
 16 10  1  0
 16 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28259

> <plate>
Kinase v5-1

> <well>
C08

> <supplier_cmpd_name>
LFM-A13

> <ctcr_id>
7671

> <supplier_cmpd_id>
1300

> <smiles>
C/C(O)=C(C#N)/C(=O)Nc1cc(Br)ccc1Br

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{FMA1,"FM A1",lfm-a13,lfma13,"lfm a13",244240-24-2,244240242,"244240 24 2","(Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide","(Z)2cyanoN(2,5dibromophenyl)3hydroxybut2enamide","(Z) 2 cyano N (
2,5 dibromophenyl) 3 hydroxybut 2 enamide",62004,1300,LFM-A13}

> <pdid>
PD002701

> <targets>
{BTK,Btk,JAK,"Polo-like Kinase (PLK)"}

> <classes>
{Cell Cycle/DNA Damage,Epigenetics,JAK/STAT Signaling,Protein Tyrosine Kinase/RTK,Stem Cell/Wnt}

> <pubchem_cids>
{54676905}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    3.8976   -0.7553    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -3.8976   -0.7554    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 N   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -7.7905   -6.0071    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -7.7897   -3.0041    0.0000 N   0  0
   -7.7876   -1.5032    0.0000 C   0  0
   -6.4873   -0.7555    0.0000 O   0  0
   -9.0858   -0.7502    0.0000 C   0  0
   -9.0859    0.7498    0.0000 C   0  0
  -10.3850    1.4998    0.0000 C   0  0
  -11.6840    0.7498    0.0000 C   0  0
  -12.9831    1.4998    0.0000 O   0  0
  -11.6840   -0.7502    0.0000 C   0  0
  -10.3850   -1.5002    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  8 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 22  1  0
 18 29  2  0
 29 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28260

> <plate>
Kinase v5-1

> <well>
C10

> <supplier_cmpd_name>
ZM 336372

> <ctcr_id>
6033

> <supplier_cmpd_id>
1321

> <smiles>
CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2

> <pd_targets>
{ALOX15,KDM4E,MAPT,IMPA1,CYP3A4,MAPK14,RAF1,RORC,ALDH1A1,LEF,TP53,BRAF,LCK,HSD17B10,CYP1A2,MAPK11,HPGD}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Transcription factor",Oxidoreductase,Eraser,Hydrolase,"Cytochrome P450",Kinase,"Nuclear receptor",Protease,"Lysine demethylase","Cytochrome P4
50 family 3","Protein Kinase","Nuclear hormone receptor subfamily 1","Metallo protease","Cytochrome P450 family 1","Jumonji domain-containing","Cytochrome P450 family 3A","CMGC protein kinase group","
TKL protein kinase group","Nuclear hormone receptor subfamily 1 group F","Metallo protease MAE clan","TK protein kinase group","Cytochrome P450 family 1A","Cytochrome P450 3A4","CMGC protein kinase MA
PK family","TKL protein kinase RAF family","Nuclear hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Tyrosine protein kinase Src family","Cytochrome P450 1A1","CMGC protei
n kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Eicosanoid turnover","Chromatin modifying enzymes","Inositol phosphate turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","Catalytic receptors","Nuclear hormone receptors",Lipoxyge
nases,"1.14.11.- Histone demethylases","Inositol monophosphatase","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","1F. Retinoic acid-related orphans","CYP1 family","Pr
ostaglandin synthases","Mitogen-activated protein kinases (MAP kinases)","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","p38 subfamily","RAF family","Non-receptor tyrosine kinases (nRTKs)","Src fam
ily"}

> <pathway_reactome>
{Metabolism,"Neuronal System","Immune System","Signal Transduction","Gene expression (Transcription)",Disease,"Cell Cycle","Metabolism of lipids","Transmission across Chemical Synapses","Inositol phos
phate metabolism","Innate Immune System","MAPK family signaling cascades","RNA Polymerase II Transcription","Biological oxidations","Infectious disease","Cell Cycle Checkpoints","Signaling by Receptor
 Tyrosine Kinases","Metabolism of amino acids and derivatives","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotransmitter receptors and postsynaptic signal transmission","Synthesis 
of IP2",IP,"and Ins in the cytosol","Toll-like Receptor Cascades","MAPK1/MAPK3 signaling","Generic Transcription Pathway","Phase I - Functionalization of compounds","Uptake and actions of bacterial to
xins","G1/S DNA Damage Checkpoints","Signaling by NTRKs","HIV Infection","Branched-chain amino acid catabolism","Biosynthesis of DPA-derived SPMs","Activation of NMDA receptors and postsynaptic events
","Biosynthesis of DHA-derived SPMs","Toll Like Receptor 5 (TLR5) Cascade","RAF/MAP kinase cascade","Transcriptional regulation by RUNX3","Ethanol oxidation","Uptake and function of anthrax toxins","p
53-Dependent G1/S DNA damage checkpoint","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Cytochrome P450 - arranged by substrate type","Biosynthesis of DPAn-3 SPMs","Post NMDA receptor
 activation events","Biosynthesis of maresins","MyD88 cascade initiated on plasma membrane","Negative regulation of MAPK pathway","RUNX3 Regulates Immune Response and Cell Migration","p53-Dependent G1
 DNA Damage Response","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis",Xenobiotics,"Biosynthesis of D-series resolvins","Biosynthesis of DPAn-3-derived protectins a
nd resolvins","Activation of AMPK downstream of NMDARs","Biosynthesis of maresin-like SPMs","MAP kinase activation","Negative feedback regulation of MAPK pathway","Stabilization of p53","Prolonged ERK
 activation events","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAPK targets/ N
uclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","ARMS-mediated activation","Nef Mediated CD4 Down-regulation","Activation of the AP-1 family of transcription f
actors"}

> <broad_targets>
{BRAF,LCK,MAPK14,RAF1}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{"ZM 336372",208260-29-1,208260291,ZM336372,ZM-336372,3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide,3(dimethylamino)N(3(4hydroxybenzamido)4methylphenyl)benzamide,N-(5-(3-Dimethy
laminobenzamido)-2-methylphenyl)-4-hydroxybenzamide,N(5(3Dimethylaminobenzamido)2methylphenyl)4hydroxybenzamide,CHEMBL186526,3-(dimethylamino)-N-(3-((4-hydroxybenzoyl)amino)-4-,3(dimethylamino)N(3((4h
ydroxybenzoyl)amino)4,T1851,1321,S2720,EI-298}

> <pdid>
PD010695

> <targets>
{Raf,cRAF}

> <classes>
{MAPK}

> <pubchem_cids>
{5730}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 15  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  8  1  0
 13 14  2  0
 14  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28261

> <plate>
Kinase v5-1

> <well>
C12

> <supplier_cmpd_name>
ZM 449829

> <ctcr_id>
6521

> <supplier_cmpd_id>
1366

> <smiles>
C=CC(=O)c1ccc2ccccc2c1

> <pd_targets>
{THRB,JAK3,EGFR,JAK1,MAPT,RORC,KDM4E,ALDH1A1,ALOX15,FTL,MAPK1,TP53,ALOX12,HPGD,CYP3A4,HSD17B10,REP,PKM,FFP,LEF}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Transcription factor","Epigenetic regulator","Unclassified protein",Kinase,Protease,"Nuclear receptor",Eraser,Oxidoreductase,"Cytochrome P450",Transferase,"Protein K
inase","Cysteine protease","Nuclear hormone receptor subfamily 1","Lysine demethylase","Cytochrome P450 family 3","Metallo protease","TK protein kinase group","Cysteine protease CA clan","Nuclear horm
one receptor subfamily 1 group F","Jumonji domain-containing","CMGC protein kinase group","Cytochrome P450 family 3A","Metallo protease MAE clan","Tyrosine protein kinase JakA family","Tyrosine protei
n kinase EGFR family","Cysteine protease C1A family","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase MAPK family","Cytochrome P450 3A4","Metallo protease M34 family","CMGC
 protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Nuclear hormone receptors","Chromatin modifying enzymes","Eicosanoid turnover","Kinases (EC 2.7.x.x)","Cytochrome P450","Anti-infectiv
e targets","2.7.1.40 Pyruvate kinases","Receptor kinases","1F. Retinoic acid-related orphans","1.14.11.- Histone demethylases",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglan
din synthases","CYP3 family","Viral protein targets","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Coronavirus (CoV) proteins","Non-receptor tyrosine kinases (nRTKs)","Recep
tor tyrosine kinases (RTKs)","ERK subfamily","Janus kinase (JakA) family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Neuronal System","Gene expression (Transcription)",Metabolism,"Vesicle-mediated transport","Cell Cycle",Disease,"Cytokine Signaling in Immune system","Signaling
 by GPCR","Transmission across Chemical Synapses","RNA Polymerase II Transcription","Biological oxidations","Metabolism of lipids","Membrane Trafficking","Innate Immune System","Cell Cycle Checkpoints
","Metabolism of amino acids and derivatives","Infectious disease","Metabolism of carbohydrates","Signaling by Interleukins","GPCR downstream signalling","Interferon Signaling","Neurotransmitter recep
tors and postsynaptic signal transmission","Generic Transcription Pathway","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","trans-Golgi Network V
esicle Budding","Toll-like Receptor Cascades","G1/S DNA Damage Checkpoints","Branched-chain amino acid catabolism","SARS-CoV Infections","Glucose metabolism","Uptake and actions of bacterial toxins","
Interleukin-2 family signaling","G alpha (q) signalling events","Antiviral mechanism by IFN-stimulated genes","Activation of NMDA receptors and postsynaptic events","Transcriptional regulation by RUNX
3","Ethanol oxidation","Biosynthesis of DPA-derived SPMs","Golgi Associated Vesicle Biogenesis","Toll Like Receptor 5 (TLR5) Cascade","p53-Dependent G1/S DNA damage checkpoint","Biosynthesis of DHA-de
rived SPMs","SARS-CoV-2 Infection",Glycolysis,"Uptake and function of anthrax toxins","Interleukin-15 signaling","Gastrin-CREB signalling pathway via PKC and MAPK","ISG15 antiviral mechanism","Post NM
DA receptor activation events","RUNX3 Regulates Immune Response and Cell Migration","Biosynthesis of DPAn-3 SPMs","MyD88 cascade initiated on plasma membrane","p53-Dependent G1 DNA Damage Response","B
iosynthesis of D-series resolvins","Biosynthesis of maresins","SARS-CoV-2 Genome Replication and Transcription","EGFR Transactivation by Gastrin","Activation of AMPK downstream of NMDARs","Biosynthesi
s of DPAn-3-derived protectins and resolvins","MAP kinase activation","Stabilization of p53","Biosynthesis of DPAn-3-derived maresins","Biosynthesis of maresin-like SPMs","Replication of the SARS-CoV-
2 genome","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{"ZM 449829",4452-06-6,4452066,"4452 06 6",1-naphthalen-2-ylprop-2-en-1-one,1naphthalen2ylprop2en1one,"1 naphthalen 2 ylprop 2 en 1 one",1-(2-naphthyl)prop-2-en-1-one,1(2naphthyl)prop2en1one,"1 (2 nap
hthyl)prop 2 en 1 one",1-(2-Naphthalenyl)-2-,1(2Naphthalenyl)2,1366,EI-357}

> <pdid>
PD021917

> <targets>
{JAK3,JAK-3}

> <classes>
{}

> <pubchem_cids>
{3799}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  0  0            999 V2000
    8.9837   -4.5059    0.0000 Cl  0  0
    2.5912   -7.5086    0.0000 C   0  0
    2.5917   -6.0086    0.0000 C   0  0
    1.2926   -5.2586    0.0000 C   0  0
    3.8912   -5.2578    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    5.1873   -7.5117    0.0000 C   0  0
    6.4837   -8.2663    0.0000 C   0  0
    6.4785   -9.7663    0.0000 C   0  0
    5.1769  -10.5118    0.0000 C   0  0
    3.8804   -9.7573    0.0000 C   0  0
    3.8856   -8.2573    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  1  0
 18 19  2  0
 19 10  1  0
  5 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28262

> <plate>
Kinase v5-1

> <well>
C14

> <supplier_cmpd_name>
ZM 39923 hydrochloride

> <ctcr_id>
1489

> <supplier_cmpd_id>
1367

> <smiles>
Cl.CC(C)N(CCC(=O)c1ccc2ccccc2c1)Cc3ccccc3

> <pd_targets>
{ALOX12,MAPT,LEF,TP53,JAK1,JAK3,HIF1A,ALDH1A1,CYP3A4,CYP2C9,TGM2,HSD17B10,CYP2C19,RORC,CYP1A2,ALOX15,THPO,CYP2D6,NFKB1,FFP,REP,MAPK1,EGFR,KDM4E,HPGD,LMNA,BLM,FTL,TGR,HSP90AA1,PMP22,POLB,AMPC,GMNN,ATM,
MTOR}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Transcription factor","Unclassified protein","Epigenetic regulator","Other nuclear protein",Protease,Kinase,Oxidoreductase,"Cytochrome P450",Aminoacyltransferase,"Nu
clear receptor",Transferase,Eraser,Hydrolase,"Metallo protease","Protein Kinase","Cysteine protease","Cytochrome P450 family 3","Cytochrome P450 family 2","Protein-glutamine glutamyl-transferase","Nuc
lear hormone receptor subfamily 1","Cytochrome P450 family 1","Lysine demethylase","Metallo protease MAE clan","TK protein kinase group","Cysteine protease CA clan","Cytochrome P450 family 3A","Cytoch
rome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 1A","Cytochrome P450 family 2D","CMGC protein kinase group","Jumonji domain-containing","Atypical protein ki
nase group","Metallo protease M34 family","Tyrosine protein kinase JakA family","Cysteine protease C1A family","Cytochrome P450 3A4","Cytochrome P450 2C9","Cytochrome P450 2C19","Nuclear hormone recep
tor subfamily 1 group F member 3","Cytochrome P450 1A1","Cytochrome P450 2D6","CMGC protein kinase MAPK family","Tyrosine protein kinase EGFR family","Atypical protein kinase PIKK family","CMGC protei
n kinase ERK1","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets","Eicosanoid turnover","Catalytic receptors","Cytochrome P450","2.3.2.- Aminoacyltransferases","Nuclear hormone receptors","Anti-infective targets","Kinases (
EC 2.7.x.x)","Chromatin modifying enzymes","Heat shock proteins",Lipoxygenases,"Receptor kinases","CYP3 family","CYP2 family: drug metabolising subset","2.3.2.13 Transglutaminases","1F. Retinoic acid-
related orphans","CYP1 family","Viral protein targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","1.14.11.- Histone demethylases","Prostaglandin synthases",Atypical,"TK: Tyrosine kinase","Corona
virus (CoV) proteins","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","Recepto
r tyrosine kinases (RTKs)","Other PIKK family kinases","FRAP subfamily","Janus kinase (JakA) family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{Metabolism,"Neuronal System",Disease,"Cell Cycle","Immune System","Cellular responses to external stimuli","Gene expression (Transcription)",Hemostasis,"Signal Transduction","DNA Repair","Vesicle-med
iated transport","Developmental Biology","Metabolism of lipids","Transmission across Chemical Synapses","Infectious disease","Cell Cycle Checkpoints","Cytokine Signaling in Immune system","Cellular re
sponses to stress","Biological oxidations","Metabolism of amino acids and derivatives","RNA Polymerase II Transcription","Platelet activation","signaling and aggregation","Innate Immune System","Signa
ling by GPCR",Mitotic,"DNA Double-Strand Break Repair","Membrane Trafficking","Nervous system development","Base Excision Repair","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotran
smitter receptors and postsynaptic signal transmission","Uptake and actions of bacterial toxins","G1/S DNA Damage Checkpoints","Interferon Signaling","Signaling by Interleukins","Cellular response to 
hypoxia","Phase I - Functionalization of compounds","Branched-chain amino acid catabolism","Generic Transcription Pathway","Platelet Aggregation (Plug Formation)","SARS-CoV Infections","Toll-like Rece
ptor Cascades","GPCR downstream signalling","M Phase","Homology Directed Repair","trans-Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","EGR2 and SOX10-mediated initiation of Schwann cell myel
ination","Resolution of Abasic Sites (AP sites)","Mitotic G1 phase and G1/S transition","Biosynthesis of DPA-derived SPMs","Activation of NMDA receptors and postsynaptic events","Uptake and function o
f anthrax toxins","p53-Dependent G1/S DNA damage checkpoint","Antiviral mechanism by IFN-stimulated genes","Interleukin-2 family signaling","Oxygen-dependent proline hydroxylation of Hypoxia-inducible
 Factor Alpha","Ethanol oxidation","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Transcriptional regulation by RUNX3","Interleukin-1 family signaling","SARS-CoV-2 
Infection","Toll Like Receptor 5 (TLR5) Cascade","G alpha (q) signalling events","Mitotic Metaphase and Anaphase","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Golgi A
ssociated Vesicle Biogenesis","G2/M Transition","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","G1/S Transition","Transcriptional Regulation by TP53","Biosynthesis of D
PAn-3 SPMs","Post NMDA receptor activation events","p53-Dependent G1 DNA Damage Response","ISG15 antiviral mechanism","Interleukin-15 signaling","Biosynthesis of maresins",Xenobiotics,"RUNX3 Regulates
 Immune Response and Cell Migration","Interleukin-1 signaling","SARS-CoV-2 Genome Replication and Transcription","MyD88 cascade initiated on plasma membrane","Gastrin-CREB signalling pathway via PKC a
nd MAPK","Biosynthesis of D-series resolvins","Mitotic Anaphase","HDR through Homologous Recombination (HRR)","Centrosome maturation","PCNA-Dependent Long Patch Base Excision Repair","Activation of th
e pre-replicative complex","Regulation of TP53 Activity","Biosynthesis of DPAn-3-derived maresins","Activation of AMPK downstream of NMDARs","Stabilization of p53","Biosynthesis of maresin-like SPMs",
"CYP2E1 reactions","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of DPAn-3-derived protectins and resolvins","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Replicatio
n of the SARS-CoV-2 genome","MAP kinase activation","EGFR Transactivation by Gastrin","Nuclear Envelope (NE) Reassembly","Homologous DNA Pairing and Strand Exchange","Loss of proteins required for int
erphase microtubule organization from the centrosome","Regulation of TP53 Expression and Degradation","Autodegradation of the E3 ubiquitin ligase COP1","MAPK targets/ Nuclear events mediated by MAP ki
nases","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","ERK/
MAPK targets","ERKs are inactivated"}

> <broad_targets>
{JAK1,JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{"ZM 39923 hydrochloride",1021868-92-7,1021868927,58753-54-1,58753541,"ZM 39923 HCl","jak3 inhibitor iv","ZM39923 hydrochloride","ZM39923 (hydrochloride)","ZM 39923","ZM39923 HCl",CHEMBL538798,"3-(ben
zyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one hydrochl","3(benzyl(isopropyl)amino)1(naphthalen2yl)propan1one hydrochl",T2460,"EMD 420121",1367,S8004,420121}

> <pdid>
PD048975

> <targets>
{"JAK Kinase",JAK,JAK3}

> <classes>
{JAK/STAT,Epigenetics,JAK/STAT Signaling,Stem Cell/Wnt}

> <pubchem_cids>
{176406,74765369}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
    1.1812   -9.7838    0.0000 O   0  0
    0.7130   -8.3588    0.0000 C   0  0
   -0.7552   -8.0517    0.0000 C   0  0
   -1.7553   -9.1697    0.0000 Br  0  0
   -1.2234   -6.6267    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
    1.2449   -5.8157    0.0000 C   0  0
    1.7131   -7.2408    0.0000 C   0  0
    3.1813   -7.5478    0.0000 Br  0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 I   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  6 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 11  1  0
 21 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28263

> <plate>
Kinase v5-1

> <well>
C16

> <supplier_cmpd_name>
GW 5074

> <ctcr_id>
7258

> <supplier_cmpd_id>
1381

> <smiles>
Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23

> <pd_targets>
{REP,BRAF,RAF1,PIM2,MAPK3,MAP3K20,RECQL,MAPT,HIF1A,MAPK1,STAT6,RORC,CHRM1,HPGD,HBB,CYP2D6,PLK4,LMNA,ARAF,FTL,KMT2A,MEN1,HSD17B10,CYP2C19,FFP,ALOX15,APEX1,BRCA1,NFKB1,TSHR,BLM,PMP22,CYP2C9,USP2,DYRK4,R
IPK3,THRB,CYP3A4,PLK1,CSNK2A1,LEF,MYOC,POLB,GMNN,CYP1A2,KIF15,MTOR,LRRK2,APH1A,APH1B,NCSTN,PSEN1,PSEN2,PSENEN}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","TKL protein kinase group","CAMK protein kinase group","CMGC protein kinase group","TKL protein kinase RAF family","CAMK protein kinase PIM family","CMGC pr
otein kinase MAPK family","CMGC protein kinase ERK1","Other cytosolic protein","Transcription factor","Membrane receptor","Secreted protein","Other nuclear protein","Unclassified protein","Epigenetic 
regulator","Nuclear receptor","Family A G protein-coupled receptor","Cytochrome P450",Reader,Oxidoreductase,Protease,"Nuclear hormone receptor subfamily 1","Small molecule receptor (family A GPCR)","C
ytochrome P450 family 2",Bromodomain,"Peptide receptor (family A GPCR)","Cysteine protease","Cytochrome P450 family 3","Metallo protease","Cytochrome P450 family 1","Nuclear hormone receptor subfamily
 1 group F","Monoamine receptor","Cytochrome P450 family 2D","Other protein kinase group","Cytochrome P450 family 2C","Glycohormone receptor","Cysteine protease CA clan","Nuclear hormone receptor subf
amily 1 group A","Cytochrome P450 family 3A","Metallo protease MAE clan","Cytochrome P450 family 1A","Atypical protein kinase group","TKL protein kinase MLK family","Nuclear hormone receptor subfamily
 1 group F member 3","Acetylcholine receptor","Cytochrome P450 2D6","Other protein kinase PLK family","Cytochrome P450 2C19","Cytochrome P450 2C9","Cysteine protease C19 family","CMGC protein kinase D
YRK family","Nuclear hormone receptor subfamily 1 group A member 2","Cytochrome P450 3A4","Other protein kinase CK2 family","Cysteine protease C1A family","Metallo protease M34 family","Cytochrome P45
0 1A1","Atypical protein kinase PIKK family","TKL protein kinase MLK subfamily","Atypical protein kinase FRAP subfamily","Aspartic protease","Aspartic protease AD clan","TKL protein kinase LRRK family
","Aspartic protease A22A subfamily","Aspartic protease A22A regulatory subfamily"}

> <pathway_chembl>
{"Other protein targets",Receptors,Enzymes,"Anti-infective targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Viral protein targets","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein 
kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Coronavirus (CoV) proteins","TKL: Tyrosine kinase-like","PIM family","Mitogen-activated protein kinases (MAP kinases)","RAF family","ERK subfa
mily","Transcription factors","Nuclear hormone receptors","G protein-coupled receptors","Eicosanoid turnover","Cytochrome P450","Chromatin modifying enzymes","Peptidases and proteinases","STAT transcr
iption factors","1F. Retinoic acid-related orphans","Acetylcholine receptors (muscarinic)","Prostaglandin synthases","CYP2 family: drug metabolising subset","2.1.1.43 Histone methyltransferases (HMTs)
",Lipoxygenases,"Glycoprotein hormone receptors","CA: Cysteine (C) Peptidases","1A. Thyroid hormone receptors","CYP3 family","CYP1 family",Atypical,"Other protein kinases","C19: Ubiquitin-specific pro
tease","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Mixed Lineage Kinase (MLK) family","Polo-like kin
ase (PLK) family","Dyrk1 subfamily","Receptor interacting protein kinase (RIPK) family","Casein kinase 2 (CK2) family","FRAP subfamily","MLK subfamily","Leucine-rich repeat kinase (LRRK) family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Immune System","Infectious disease","Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","Innate Immune System","SARS-CoV Infections","Signaling by
 NTRKs","MAPK1/MAPK3 signaling","Toll-like Receptor Cascades","SARS-CoV-2 Infection","Signaling by NTRK1 (TRKA)","RAF/MAP kinase cascade","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-2 Genome Repli
cation and Transcription","Signalling to ERKs","Negative regulation of MAPK pathway","MyD88 cascade initiated on plasma membrane","Replication of the SARS-CoV-2 genome","Prolonged ERK activation event
s","Negative feedback regulation of MAPK pathway","MAP kinase activation","ARMS-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated","N
euronal System","Cellular responses to external stimuli","Gene expression (Transcription)",Metabolism,"Cell Cycle","Vesicle-mediated transport","DNA Repair","Developmental Biology","Metabolism of prot
eins","Transmission across Chemical Synapses","Cellular responses to stress","RNA Polymerase II Transcription","Signaling by GPCR","Metabolism of lipids","Biological oxidations",Mitotic,"Diseases of s
ignal transduction by growth factor receptors and second messengers","Membrane Trafficking","Metabolism of amino acids and derivatives","Base Excision Repair","DNA Double-Strand Break Repair","Cytokin
e Signaling in Immune system","Nervous system development","Post-translational protein modification","Neurotransmitter receptors and postsynaptic signal transmission","Cellular response to hypoxia","C
ytosolic sensors of pathogen-associated DNA","Generic Transcription Pathway","GPCR ligand binding","Biosynthesis of specialized proresolving mediators (SPMs)","Neutrophil degranulation","Phase I - Fun
ctionalization of compounds","Mitotic G2-G2/M phases","M Phase","Oncogenic MAPK signaling","trans-Golgi Network Vesicle Budding","Branched-chain amino acid catabolism","Resolution of Abasic Sites (AP 
sites)","Homology Directed Repair","Signaling by Interleukins","Leishmania infection","EGR2 and SOX10-mediated initiation of Schwann cell myelination",SUMOylation,"Uptake and actions of bacterial toxi
ns","Mitotic G1 phase and G1/S transition","Intra-Golgi and retrograde Golgi-to-ER traffic","Activation of NMDA receptors and postsynaptic events","Oxygen-dependent proline hydroxylation of Hypoxia-in
ducible Factor Alpha","STING mediated induction of host immune responses","Transcriptional regulation by RUNX3","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Cytochrome P4
50 - arranged by substrate type","G2/M Transition","Mitotic Metaphase and Anaphase","Signaling by RAS mutants","Golgi Associated Vesicle Biogenesis","Transcriptional regulation by RUNX1","Biosynthesis
 of DPA-derived SPMs","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Interleukin-1 family
 signaling","Leishmania parasite growth and survival","Transcriptional Regulation by TP53","Toll Like Receptor 4 (TLR4) Cascade","SUMO E3 ligases SUMOylate target proteins","Uptake and function of ant
hrax toxins","G1/S Transition","Golgi-to-ER retrograde transport","Post NMDA receptor activation events","STAT6-mediated induction of chemokines","RUNX3 Regulates Immune Response and Cell Migration","
Amine ligand-binding receptors","Biosynthesis of D-series resolvins",Xenobiotics,"Centrosome maturation","Mitotic Anaphase","Signaling downstream of RAS mutants","RUNX1 regulates genes involved in meg
akaryocyte differentiation and platelet function","Biosynthesis of DPAn-3 SPMs","PCNA-Dependent Long Patch Base Excision Repair","HDR through Homologous Recombination (HRR)","Interleukin-1 signaling",
"Anti-inflammatory response favouring Leishmania parasite infection","Regulation of TP53 Activity","MyD88-independent TLR4 cascade","SUMOylation of intracellular receptors","Biosynthesis of maresins",
"Activation of the pre-replicative complex","COPI-dependent Golgi-to-ER retrograde traffic","Activation of AMPK downstream of NMDARs","Muscarinic acetylcholine receptors","CYP2E1 reactions","Loss of p
roteins required for interphase microtubule organization from the centrosome","Nuclear Envelope (NE) Reassembly","Biosynthesis of DPAn-3-derived protectins and resolvins","Homologous DNA Pairing and S
trand Exchange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","ADORA2B mediated anti-inflammatory cytokines production","Regulation of TP53 Expression and Degradation","TRIF(TICAM1)-mediated TLR4 signa
ling","Biosynthesis of maresin-like SPMs","Regulation of TP53 Activity through Phosphorylation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Loss of Nlp from mitotic centrosomes
","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation","IKK complex recruitment mediated by RIP1","Signa
ling by Non-Receptor Tyrosine Kinases","Signaling by PTK6","PTK6 promotes HIF1A stabilization"}

> <broad_targets>
{NTRK1,RAF1}

> <broad_moa>
{"leucine rich repeat kinase inhibitor","RAF inhibitor"}

> <synonyms>
{"Raf1 Kinase Inhibitor I",gw5074,220904-83-6,220904836,"GW 5074",GW-5074,GW5074,UNII-B7W8RS1GG2,UNIIB7W8RS1GG2,B7W8RS1GG2,"(3Z)-3-((3,5-dibromo-4-hydroxyphenyl)methylidene)-5-iodo-1H-indol-2-one","(3
Z)3((3,5dibromo4hydroxyphenyl)methylidene)5iodo1Hindol2one","3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one","3(3,5Dibromo4hydroxybenzylidene)5iodo1,3dihydroindol2one",CHEMBL7236
5,3,1381,S2872}

> <pdid>
PD002729

> <targets>
{Raf}

> <classes>
{}

> <pubchem_cids>
{5924208}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
   -3.9477   -7.1844    0.0000 C   0  0
   -2.8628   -6.1485    0.0000 C   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 C   0  0
   -3.2175   -4.6910    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8788   -1.4412    0.0000 C   0  0
    4.8834   -2.5550    0.0000 C   0  0
    4.3416   -0.0143    0.0000 C   0  0
    5.3458   -1.1283    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17  8  1  0
 17 11  1  0
 10 18  1  0
 18 19  1  0
 18 20  1  0
 18 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28264

> <plate>
Kinase v5-1

> <well>
C18

> <supplier_cmpd_name>
PP 1

> <ctcr_id>
4913

> <supplier_cmpd_id>
1397

> <smiles>
Cc1ccc(cc1)c2nn(c3ncnc(N)c23)C(C)(C)C

> <pd_targets>
{PDGFRA,CSNK1D,CSK,CDC42BPA,FLT3,ABL1,BLK,EPHA2,CLK4,SRC,NTRK3,FRK,LIMK1,KIT,INSR,EGFR,KDR,FYN,PRKACA,RPS6KB1,MTOR,LCK,MAPK9,KDM4E,AMPC,RET,CLK2,MAP3K20,LYN,BTK,NTRK2,FGFR3,HTT,RORC,CSNK1A1,MARK2,FLT1
,ERBB4,TEK,ROCK2,WNK1,RPS6KA3,PLK4,RIPK2,CSF1R,AKT3,ERBB2,PRKD3,SLK,YES1,AURKB,LMNA,TAOK1,SRMS,PTK6,FLT4,HPGD,RPL19A,PRKD2,ROCK1,MAPK14,STK3,ALDH1A1,MAP4K4,IRAK4,FGFR1,ROS1}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Unclassified protein","Transcription factor","Other nuclear protein",Kinase,Eraser,Hydrolase,"Nuclear receptor",Oxidoreductase,"Protein Kinase","Lysine demethylase","Nu
clear hormone receptor subfamily 1","TK protein kinase group","CK1 protein kinase group","AGC protein kinase group","CMGC protein kinase group","TKL protein kinase group","Atypical protein kinase grou
p","Jumonji domain-containing","Nuclear hormone receptor subfamily 1 group F","CAMK protein kinase group","Other protein kinase group","STE protein kinase group","Tyrosine protein kinase PDGFR family"
,"CK1 protein kinase CK1 family","Tyrosine protein kinase Csk family","AGC protein kinase DMPK family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Src family","Tyrosine protein kinas
e Eph family","CMGC protein kinase CLK family","Tyrosine protein kinase Trk family","TKL protein kinase LISK family","Tyrosine protein kinase InsR family","Tyrosine protein kinase EGFR family","Tyrosi
ne protein kinase VEGFR family","AGC protein kinase PKA family","AGC protein kinase RSK family","Atypical protein kinase PIKK family","CMGC protein kinase MAPK family","Tyrosine protein kinase Ret fam
ily","TKL protein kinase MLK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase FGFR family","Nuclear hormone receptor subfamily 1 group F member 3","CAMK protein kinase CAMK1 famil
y","Tyrosine protein kinase Tie family","Other protein kinase Wnk family","Other protein kinase PLK family","TKL protein kinase RIPK family","AGC protein kinase AKT family","CAMK protein kinase PKD fa
mily","STE protein kinase STE20 family","Other protein kinase AUR family","TKL protein kinase IRAK family","Tyrosine protein kinase Sev family","AGC protein kinase GEK subfamily","TKL protein kinase L
IMK subfamily","Tyrosine protein kinase SrcA","AGC protein kinase p70 subfamily","Atypical protein kinase FRAP subfamily","CMGC protein kinase JNK subfamily","TKL protein kinase MLK subfamily","CAMK p
rotein kinase MARK subfamily","AGC protein kinase ROCK subfamily","AGC protein kinase RSK subfamily","STE protein kinase SLK subfamily","STE protein kinase TAO subfamily","Tyrosine protein kinase Srm"
,"CMGC protein kinase p38 subfamily","STE protein kinase MST subfamily","STE protein kinase MSN subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Nuclear hormone receptors","Eicosanoid turnover","Receptor kinases","CK1: Casein kinase 1","AGC: Containi
ng PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"1.14.11.- Histone demethylases","1F. Retinoic acid-related orphans","CAMK: Calcium/calmodulin-dependent protein kin
ases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Prostaglandin synthases","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","DMPK family","CLK family","TKL: Tyrosine kina
se-like","Protein kinase A (PKA) family","RSK family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Mitogen-activated protein kinases (MAP kinases)","CAMK-like (CAMKL) family","Othe
r protein kinases","Akt (Protein kinase B","PKB) family","Protein kinase D (PKD) family","STE20 family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","GEK subfamily","LIM 
domain kinase (LISK) family","p70 subfamily","FRAP subfamily","JNK subfamily","Mixed Lineage Kinase (MLK) family","MARK subfamily","Rho kinase","Wnk family","RSK subfamily","Polo-like kinase (PLK) fam
ily","Receptor interacting protein kinase (RIPK) family","SLK subfamily","Aurora kinase (Aur) family","TAO subfamily","p38 subfamily","MST subfamily","MSN subfamily","Interleukin-1 receptor-associated
 kinase (IRAK) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Csk family","Abl family","Src family","Type XIII RTKs: Ephrin receptor family","Type VII RTKs: Neurotrophin receptor/Trk 
family","LIMK subfamily","Type II RTKs: Insulin receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"
,"Type XIV RTKs: RET","MLK subfamily","Tec family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Type XVII RTKs: ROS receptors"}

> <pathway_reactome>
{Disease,"Cell Cycle","Signal Transduction","Gene expression (Transcription)","Developmental Biology","Immune System","Neuronal System","Transport of small molecules",Metabolism,"Cellular responses to
 external stimuli","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Signaling by Receptor Tyrosine Kinases","Infectious disease","RNA Polymerase II Transcrip
tion","Nervous system development","Intracellular signaling by second messengers","Signaling by GPCR","MTOR signalling","Innate Immune System","Transmission across Chemical Synapses","MAPK family sign
aling cascades","Ion channel transport","Metabolism of lipids","Signaling by Non-Receptor Tyrosine Kinases","Signaling by Hippo","Biological oxidations","Cellular responses to stress","Signaling by PD
GFR in disease","Mitotic G2-G2/M phases","Oncogenic MAPK signaling","Signaling by Insulin receptor","Leishmania infection","Generic Transcription Pathway","Axon guidance","Signaling by NTRKs","PIP3 ac
tivates AKT signaling","Signaling by KIT in disease","GPCR downstream signalling","Signaling by VEGF","HIV Infection","mTORC1-mediated signalling","Toll-like Receptor Cascades","Signaling by FGFR in d
isease","Signaling by WNT in cancer","Neurotransmitter receptors and postsynaptic signal transmission","MAPK1/MAPK3 signaling","Stimuli-sensing channels","Sphingolipid metabolism","M Phase","Signaling
 by PTK6","Mitotic G1 phase and G1/S transition","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","Cellular Senescence","Drug resistance of PDGFR 
mutants","G2/M Transition","Signaling by RAS mutants","Insulin receptor signalling cascade","Parasite infection","Transcriptional regulation by RUNX1","EPH-Ephrin signaling","Signaling by NTRK1 (TRKA)
","Signaling by NTRK3 (TRKC)","PTEN Regulation","Semaphorin interactions","Drug resistance of KIT mutants","Negative regulation of the PI3K/AKT network","G alpha (q) signalling events","VEGFA-VEGFR2 P
athway","Host Interactions of HIV factors","Transcriptional Regulation by TP53","Toll Like Receptor 5 (TLR5) Cascade","RET signaling","Leishmania parasite growth and survival","Signaling by FGFR3 in d
isease","Transcriptional Regulation by MECP2","Transcriptional regulation by RUNX3","Signaling by AMER1 mutants","VEGF ligand-receptor interactions","Activation of NMDA receptors and postsynaptic even
ts","RAF/MAP kinase cascade","Transcriptional Regulation by VENTX","Sphingolipid de novo biosynthesis","Mitotic Metaphase and Anaphase","PTK6 Down-Regulation","G1 Phase","Biosynthesis of DHA-derived S
PMs","Ethanol oxidation","Oxidative Stress Induced Senescence","Toll Like Receptor 2 (TLR2) Cascade","Signaling by FGFR1 in disease","Imatinib-resistant PDGFR mutants","Centrosome maturation","Signali
ng downstream of RAS mutants","IRS-mediated signalling","Leishmania phagocytosis","RUNX1 regulates transcription of genes involved in BCR signaling","EPHA-mediated growth cone collapse","Signalling to
 ERKs","Activated NTRK3 signals through PI3K","Regulation of PTEN stability and activity","Sema4D in semaphorin signaling","Dasatinib-resistant KIT mutants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signa
ling","Gastrin-CREB signalling pathway via PKC and MAPK","VEGFR2 mediated cell proliferation","The role of Nef in HIV-1 replication and disease pathogenesis","Regulation of TP53 Activity","MyD88 casca
de initiated on plasma membrane","Anti-inflammatory response favouring Leishmania parasite infection","Activation of TRKA receptors","Signaling by FGFR3 point mutants in cancer","Regulation of MECP2 e
xpression and activity","RUNX3 Regulates Immune Response and Cell Migration","Truncations of AMER1 destabilize the destruction complex","VEGF binds to VEGFR leading to receptor dimerization","Post NMD
A receptor activation events","Mitotic Anaphase","Cyclin D associated events in G1","Biosynthesis of D-series resolvins","Toll Like Receptor TLR6:TLR2 Cascade","FGFR1 mutant receptor activation","Loss
 of proteins required for interphase microtubule organization from the centrosome","PI3K Cascade","FCGR3A-mediated phagocytosis","Signalling to RAS","Sema4D induced cell migration and growth-cone coll
apse","EGFR Transactivation by Gastrin","Nef and signal transduction","Regulation of TP53 Expression and Degradation","Nef-mediates down modulation of cell surface receptors by recruiting them to clat
hrin adapters","MAP kinase activation","FCGR3A-mediated IL10 synthesis","NGF-independant TRKA activation","FGFR3 mutant receptor activation","Long-term potentiation","Separation of Sister Chromatids",
"Nuclear Envelope (NE) Reassembly","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Signaling by activated point mutants of FGFR1","Loss of Nlp from mitotic centrosomes","p38MAPK events","Regu
lation of TP53 Degradation","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","Signaling by activated point mutants of FGFR3","activated TAK1 mediates p38 MAPK 
activation","Initiation of Nuclear Envelope (NE) Reformation","Activation of the AP-1 family of transcription factors","CREB phosphorylation"}

> <broad_targets>
{HCK,RET}

> <broad_moa>
{"SRC inhibitor"}

> <synonyms>
{172889-26-8,172889268,PP1,"PP 1","1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1(tertButyl)3(ptolyl)1Hpyrazolo(3,4d)pyrimidin4amine","1-tert-butyl-3-(4-methylphenyl)-1h-pyrazolo(3
,4-d)pyrimidin-4-amine","1tertbutyl3(4methylphenyl)1hpyrazolo(3,4d)pyrimidin4amine","1-ter-butyl-3-p-tolyl-1h-pyrazolo(3,4-d)pyrimidin-4-ylamine","1terbutyl3ptolyl1hpyrazolo(3,4d)pyrimidin4ylamine",CH
EMBL306380,1-tert-butyl-3-,1tertbutyl3,T6196,1397,EI-275,S7060}

> <pdid>
PD008408

> <targets>
{Src,"Src family",Apoptosis}

> <classes>
{Angiogenesis,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{1400}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
    6.3982    2.8054    0.0000 Cl  0  0
    3.8976   -0.7553    0.0000 C   0  0
    2.5973   -1.5031    0.0000 S   0  0
    2.5951   -3.0031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 N   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.8193    4.6606    0.0000 C   0  0
   -4.0353    5.9336    0.0000 C   0  0
   -4.7489    7.2530    0.0000 C   0  0
   -6.2483    7.2947    0.0000 C   0  0
   -6.9619    8.6141    0.0000 F   0  0
   -7.0341    6.0170    0.0000 C   0  0
   -6.3205    4.6976    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -6.4469    1.8311    0.0000 C   0  0
   -7.4153    2.9701    0.0000 C   0  0
   -8.8906    2.6991    0.0000 C   0  0
   -9.3937    1.2860    0.0000 N   0  0
   -8.4213    0.1438    0.0000 C   0  0
   -6.9460    0.4147    0.0000 C   0  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  8 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 14  1  0
 13 21  2  0
 21 22  1  0
 22 11  2  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28265

> <plate>
Kinase v5-1

> <well>
C20

> <supplier_cmpd_name>
SB 203580 hydrochloride

> <ctcr_id>
1865

> <supplier_cmpd_id>
1402

> <smiles>
Cl.C[S](=O)c1ccc(cc1)c2[nH]c(c3ccc(F)cc3)c(n2)c4ccncc4

> <pd_targets>
{TNNI3K,GSK3B,RPS6KA6,MAPK14,MAPK11,MAPK12,MAPK13,TGFBR1,ACVR1B,LCK,TYK2,NLK,KMT2A,MEN1,HSD17B10,CSNK1A1,RAF1,MAPK9,EGFR,CYP2D6,TTK,RIPK2,GAK,CSNK1D,BRAF,MAP2K1,MAP2K2,CYP1A2,CYP3A4,HTR4,FRK,MAPK10,ST
K36,PTK6,SLK,TNIK,CDC42BPG,CDPK1,TXK,CDC42BPB,MAPK-1,RPS6KA1,EPHA6,SRC,MAPK1,STK32B,LEF,ERBB4,ALDH1A1,EPHB2,CSNK1E,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,CYP2C9,CYP2C19,MAPK
8,MAP4K4,MET,CIT,COQ8B,TGFBR2,PTGS1,ABL1,SIK2,KDM4E,SIK3,STK32A,ALOX5,TEK,DDR2,P2RX7,DDR1,ALOX15,HPGD,MAP2K5,FLT4,MAP3K20,CSNK1A1L,CDC42BPA,GCGR,PRKACA,PRKACB,PRKACG,TSHR,MINK1,BMPR1B,PIP5K1C,PRKD2,EP
HB6,TBXAS1,PDE5A,ADORA1,ADORA2A,CHRM1,ERBB2,TYR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Membrane receptor","Ion channel","Unclassified protein",Kinase,Reader,Oxidoreductase,"Cytochrome P450","Family A G protein-coupled receptor",Protease,Eraser,"Ligand-gat
ed ion channel","Family B G protein-coupled receptor",Transferase,Phosphodiesterase,"Protein Kinase",Bromodomain,"Cytochrome P450 family 2","Cytochrome P450 family 1","Cytochrome P450 family 3","Small
 molecule receptor (family A GPCR)","Metallo protease","Lysine demethylase","P2X receptor","Peptide receptor (family B GPCR)","Peptide receptor (family A GPCR)","Cytochrome P450 family 5","Phosphodies
terase 5","TKL protein kinase group","CMGC protein kinase group","AGC protein kinase group","TK protein kinase group","CK1 protein kinase group","Cytochrome P450 family 2D","Other protein kinase group
","STE protein kinase group","Cytochrome P450 family 1A","Cytochrome P450 family 3A","Monoamine receptor","Metallo protease MAE clan","Cytochrome P450 family 2C","Atypical protein kinase group","CAMK 
protein kinase group","Jumonji domain-containing","Glucagon-like receptor","Glycohormone receptor","Cytochrome P450 family 5A","Phosphodiesterase 5A","Nucleotide-like receptor (family A GPCR)","TKL pr
otein kinase MLK family","CMGC protein kinase GSK family","AGC protein kinase RSK family","CMGC protein kinase MAPK family","TKL protein kinase STKR family","Tyrosine protein kinase Src family","Tyros
ine protein kinase JakA family","CK1 protein kinase CK1 family","TKL protein kinase RAF family","Tyrosine protein kinase EGFR family","Cytochrome P450 2D6","Other protein kinase TTK family","TKL prote
in kinase RIPK family","Other protein kinase NAK family","STE protein kinase STE7 family","Cytochrome P450 1A1","Cytochrome P450 3A4","Serotonin receptor","Other protein kinase ULK family","STE protei
n kinase STE20 family","AGC protein kinase DMPK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Eph family","AGC protein kinase YANK family","Metallo protease M34 family","AGC pr
otein kinase PKC family","Cytochrome P450 2C9","Cytochrome P450 2C19","Tyrosine protein kinase Met family","Atypical protein kinase ABC1 family","Tyrosine protein kinase Abl family","CAMK protein kina
se CAMK1 family","Tyrosine protein kinase Tie family","Tyrosine protein kinase DDR family","Tyrosine protein kinase VEGFR family","Glucagon receptor","AGC protein kinase PKA family","CAMK protein kina
se PKD family","Cytochrome P450 5A1","Adenosine receptor","Acetylcholine receptor","TKL protein kinase HH498 subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase p38 subfamily","TKL prot
ein kinase STKR Type 1 subfamily","CMGC protein kinase nmo subfamily","CMGC protein kinase JNK subfamily","STE protein kinase SLK subfamily","STE protein kinase MSN subfamily","AGC protein kinase GEK 
subfamily","CMGC protein kinase ERK1","AGC protein kinase PKC alpha subfamily","AGC protein kinase CRIK subfamily","Atypical protein kinase ABC1-A subfamily","TKL protein kinase STKR Type 2 subfamily"
,"CAMK protein kinase QIK subfamily","TKL protein kinase MLK subfamily","CK1 protein kinase CK1-a"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","Chromatin modifying enzymes","Ligand-gated ion cha
nnels","Cyclic nucleotide turnover/signalling","1.-.-.- Oxidoreductases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase
 1","CYP2 family: drug metabolising subset","CYP1 family","CYP3 family","5-Hydroxytryptamine receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Atypical,Cyclooxygenase,"CA
MK: Calcium/calmodulin-dependent protein kinases","1.14.11.- Histone demethylases",Lipoxygenases,"P2X receptors","Prostaglandin synthases","Glucagon receptor family","Glycoprotein hormone receptors","
Lipid modifying kinases",CYP5,"CYP7 and CYP8 families",Phosphodiesterases,3',"5'-cyclic nucleotide (PDEs)","Adenosine receptors","Acetylcholine receptors (muscarinic)","TKL: Tyrosine kinase-like","Gly
cogen synthase kinase (GSK) family","RSK family","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","Other protein kinases","STE20 family","DMPK fam
ily","YANK family","STE7 family","ABC1 family","CAMK-like (CAMKL) family","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","Protein kinase D (PKD) family","Mixed Lineage Kinas
e (MLK) family","GSK subfamily","RSK subfamily","p38 subfamily","Receptor serine/threonine kinase (RSTK) family","Non-receptor tyrosine kinases (nRTKs)","nmo subfamily","RAF family","JNK subfamily","R
eceptor tyrosine kinases (RTKs)","TTK family","Receptor interacting protein kinase (RIPK) family","Numb-associated kinase (NAK) family","Unc-51-like kinase (ULK) family","SLK subfamily","MSN subfamily
","GEK subfamily","ERK subfamily","Other DMPK family kinases","ABC1-B subfamily","QIK subfamily","HH498 subfamily","Type I receptor serine/threonine kinases","Src family","Janus kinase (JakA) family",
"Type I RTKs: ErbB (epidermal growth factor) receptor family","Tec family","Type XIII RTKs: Ephrin receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type II receptor seri
ne/threonine kinases","Abl family","Type XII RTKs: TIE family of angiopoietin receptors","Type XVI RTKs: DDR (collagen receptor) family","Type IV RTKs: VEGF (vascular endothelial growth factor) recept
or family","MLK subfamily"}

> <pathway_reactome>
{Disease,"Neuronal System","Immune System","Developmental Biology","Signal Transduction",Metabolism,"Vesicle-mediated transport","Cell Cycle","Cellular responses to external stimuli","Extracellular ma
trix organization",Hemostasis,"Infectious disease","Transmission across Chemical Synapses","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Si
gnaling by NODAL","Cytokine Signaling in Immune system","Signaling by WNT","Metabolism of amino acids and derivatives","MAPK family signaling cascades","Signaling by GPCR","Biological oxidations","Sig
naling by Receptor Tyrosine Kinases","Membrane Trafficking",Mitotic,"Metabolism of lipids","Intracellular signaling by second messengers","Cellular responses to stress","Nervous system development","S
ignaling by Rho GTPases","Non-integrin membrane-ECM interactions","Signaling by TGFB family members","Platelet homeostasis","SARS-CoV Infections","Neurotransmitter receptors and postsynaptic signal tr
ansmission","Toll-like Receptor Cascades","Signaling by TGF-beta Receptor Complex in Cancer","Regulation of signaling by NODAL","HIV Infection","Interferon Signaling","Beta-catenin independent WNT sig
naling","Branched-chain amino acid catabolism","Signaling by WNT in cancer","MAPK1/MAPK3 signaling","GPCR downstream signalling","Phase I - Functionalization of compounds","Signaling by NTRKs","trans-
Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","PIP3 activates AKT signaling","Mitotic G1 phase and G1/S tra
nsition","Cellular Senescence","Fc epsilon receptor (FCERI) signaling","Axon guidance","Uptake and actions of bacterial toxins","RHO GTPase Effectors","Fatty acid metabolism","Signaling by VEGF","Sign
aling by BMP","Sphingolipid metabolism","Nitric oxide stimulates guanylate cyclase","GPCR ligand binding","Melanin biosynthesis","SARS-CoV-1 Infection","Activation of NMDA receptors and postsynaptic e
vents","Toll Like Receptor 5 (TLR5) Cascade","Loss of Function of SMAD2/3 in Cancer","Host Interactions of HIV factors","Interferon alpha/beta signaling","Ca2+ pathway","Signaling by AMER1 mutants","R
AF/MAP kinase cascade","G alpha (q) signalling events","Cytochrome P450 - arranged by substrate type","Signaling by NTRK1 (TRKA)","Golgi Associated Vesicle Biogenesis","G2/M Transition","Biosynthesis 
of DHA-derived SPMs","Leishmania parasite growth and survival","PTEN Regulation","G1 Phase","Oxidative Stress Induced Senescence","FCERI mediated Ca+2 mobilization","EPH-Ephrin signaling","Uptake and 
function of anthrax toxins","Ethanol oxidation","Semaphorin interactions","RHO GTPases activate CIT","Arachidonic acid metabolism","Parasite infection","Biosynthesis of DPA-derived SPMs","Cell recruit
ment (pro-inflammatory response)","VEGF ligand-receptor interactions","Sphingolipid de novo biosynthesis","cGMP effects","Class A/1 (Rhodopsin-like receptors)","SARS-CoV-1 Genome Replication and Trans
cription","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","SMAD2/3 Phosphorylation Motif Mutants in Cancer","The role of Nef in HIV-1 replication and disease pathog
enesis","Regulation of IFNA signaling","Truncations of AMER1 destabilize the destruction complex","Negative regulation of MAPK pathway","Gastrin-CREB signalling pathway via PKC and MAPK",Xenobiotics,"
Signalling to ERKs","Centrosome maturation","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of PTEN stability and activity","Cyclin D associ
ated events in G1","EPHA-mediated growth cone collapse","EPHB-mediated forward signaling","Sema4D in semaphorin signaling","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)","Leishmania phagocyt
osis","Biosynthesis of DPAn-3 SPMs","Purinergic signaling in leishmaniasis infection","Biosynthesis of D-series resolvins","Signalling to ERK5","VEGF binds to VEGFR leading to receptor dimerization","
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion",Eicosanoids,"Nucleotide-like (purinergic) receptors","Amine ligand-binding receptors","Replication of the SARS-CoV-1 genome","CREB1 p
hosphorylation through NMDA receptor-mediated activation of RAS signaling","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Neg
ative feedback regulation of MAPK pathway","EGFR Transactivation by Gastrin","CYP2E1 reactions","Signalling to RAS","Loss of proteins required for interphase microtubule organization from the centroso
me","Prolonged ERK activation events","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammatory cytokines production","
Long-term potentiation","Sema4D mediated inhibition of cell attachment and migration","FCGR3A-mediated phagocytosis","Biosynthesis of DPAn-3-derived 13-series resolvins","Biosynthesis of DPAn-3-derive
d protectins and resolvins","Adenosine P1 receptors","Muscarinic acetylcholine receptors","Sema4D induced cell migration and growth-cone collapse","RSK activation","MAPK targets/ Nuclear events mediat
ed by MAP kinases","Nef Mediated CD4 Down-regulation","p38MAPK events","activated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","ARMS-mediated activation","Frs2-mediated ac
tivation","Activation of the AP-1 family of transcription factors","CREB phosphorylation","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,ALOX5,CHEK1,CYP2D6,CYP3A4,GAK,GSK3B,LCK,MAPK1,MAPK10,MAPK11,MAPK12,MAPK14,MAPK8,MAPK9,PRKCA,RAF1,RIPK2,ROCK1,RPS6KB1,SGK1,SRC,TNF}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"SB 203580 HYDROCHLORIDE",869185-85-3,869185853,"SB 203580 (hydrochloride)","SB203580 hydrochloride","RWJ 64809 hydrochloride","SB 2035850","SB 203580, Hydrochloride",SR-01000597367,SR01000597367,Pub
Chem24446,sb203580-hydrochloride,sb203580hydrochloride,C21H16FN3OS.ClH,SCHEM,1402,"SB 203580 hydrochloride"}

> <pdid>
PD004782

> <targets>
{"p38 MAPK",Autophagy,Mitophagy}

> <classes>
{Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{16760644}

$$$$
UTKinase_V5
  SciTegic11012413002D

 11 12  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5926    0.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  3  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9  7  1  0
  9 10  1  0
 10  2  1  0
 10 11  2  0
M  END
> <name>
UTKinase_V5

> <id>
28266

> <plate>
Kinase v5-1

> <well>
C22

> <supplier_cmpd_name>
(-)-Terreic acid

> <ctcr_id>
5729

> <supplier_cmpd_id>
1405

> <smiles>
CC1=C(O)C(=O)C2OC2C1=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Terreic acid (6CI)",SCHEMBL51230,"4-hydroxy-3-methyl-7-oxabicyclo(4.1.0)hept-3-ene-2,5-dione","4hydroxy3methyl7oxabicyclo(4.1.0)hept3ene2,5dione",J3.570.099D,J-004490,J004490,"2-Methyl-3-hydroxy-5,6
-epoxy-2-cyclohexene-1,4-dione","2Methyl3hydroxy5,6epoxy2cyclohexene1,4dione","5,6-epoxy-2-hydroxy-3-methyl-2-cyclo-hexene-1,4-dione","5,6epoxy2hydroxy3methyl2cyclohexene1,4dione",1405,EI-328,"(-)-Ter
reic acid","Terreic acid"}

> <pdid>
PD021907

> <targets>
{BTK}

> <classes>
{}

> <pubchem_cids>
{4561942}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
   -0.2290   -5.5067    0.0000 C   0  0
   -0.6913   -4.0797    0.0000 C   0  0
   -2.1584   -3.7671    0.0000 C   0  0
   -1.6957   -5.1937    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    4.9619   -2.4739    0.0000 C   0  0
    6.4015   -2.0524    0.0000 C   0  0
    6.7561   -0.5949    0.0000 C   0  0
    8.1957   -0.1733    0.0000 Cl  0  0
    5.6713    0.4410    0.0000 C   0  0
    4.2318    0.0194    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14  8  1  0
  7 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21  5  1  0
 21 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28267

> <plate>
Kinase v5-1

> <well>
E04

> <supplier_cmpd_name>
PP 2

> <ctcr_id>
4439

> <supplier_cmpd_id>
1407

> <smiles>
CC(C)(C)n1nc(c2ccc(Cl)cc2)c3c(N)ncnc13

> <pd_targets>
{RPL19A,SRC,APE1,LCK,EPHB2,FYN,SMN1,MAP2K2,TNK2,SIK2,ACVR1,HCK,RIPK2,CSK,ABL1,MAPK14,MAPK9,CYP2C19,CLK4,MELK,MAP2K1,PDGFRA,CSNK1D,PRKACA,MAPK8,CSNK1A1,BTK,CDK8,EGFR,CYP2C9,CYP1A2,CDK5,MAPK10,KDR,PDGFR
B,DAPK3}

> <pathway_gtopdb>
{"Unclassified protein",Enzyme,"Epigenetic regulator",Kinase,Protease,Reader,"Cytochrome P450","Protein Kinase","Metallo protease","Methyl-lysine/arginine binding protein","Cytochrome P450 family 2","
Cytochrome P450 family 1","TK protein kinase group","Metallo protease MH clan","Tudor domain","STE protein kinase group","CAMK protein kinase group","TKL protein kinase group","CMGC protein kinase gro
up","Cytochrome P450 family 2C","CK1 protein kinase group","AGC protein kinase group","Cytochrome P450 family 1A","Tyrosine protein kinase Src family","Metallo protease M18 family","Tyrosine protein k
inase Eph family","STE protein kinase STE7 family","Tyrosine protein kinase Ack family","CAMK protein kinase CAMK1 family","TKL protein kinase STKR family","TKL protein kinase RIPK family","Tyrosine p
rotein kinase Csk family","Tyrosine protein kinase Abl family","CMGC protein kinase MAPK family","Cytochrome P450 2C19","CMGC protein kinase CLK family","Tyrosine protein kinase PDGFR family","CK1 pro
tein kinase CK1 family","AGC protein kinase PKA family","Tyrosine protein kinase Tec family","CMGC protein kinase CDK family","Tyrosine protein kinase EGFR family","Cytochrome P450 2C9","Cytochrome P4
50 1A1","Tyrosine protein kinase VEGFR family","CAMK protein kinase DAPK family","Tyrosine protein kinase SrcA","CAMK protein kinase QIK subfamily","TKL protein kinase STKR1","CMGC protein kinase p38 
subfamily","CMGC protein kinase JNK subfamily","CAMK protein kinase MELK subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-depe
ndent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP2 family: drug metabolising subset","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","CYP1 family","TK: Tyrosi
ne kinase","STE7 family","CAMK-like (CAMKL) family","TKL: Tyrosine kinase-like","Mitogen-activated protein kinases (MAP kinases)","CLK family","Casein kinase 1 (CK1) family","Protein kinase A (PKA) fa
mily","Cyclin-dependent kinase (CDK) family","Death-associated kinase (DAPK) family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","QIK subfamily","Receptor serine/threoni
ne kinase (RSTK) family","Receptor interacting protein kinase (RIPK) family","p38 subfamily","JNK subfamily","MELK subfamily","CDK8 subfamily","CDK5 subfamily","Src family","Type XIII RTKs: Ephrin rec
eptor family","Ack family","Type I receptor serine/threonine kinases","Csk family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Tec family","Type I RTKs: ErbB (epidermal growth
 factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Developmental Biology","Metabolism of RNA","Immune System",Metabolism,"Cell Cycle","Gene expression (Transcription)","Programmed Cell Death","Signaling by Receptor Tyro
sine Kinases","Infectious disease","Nervous system development","Metabolism of non-coding RNA","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers"
,"Biological oxidations",Mitotic,"Signaling by GPCR","RNA Polymerase II Transcription","Intracellular signaling by second messengers",Apoptosis,"Signaling by NTRKs","HIV Infection","Axon guidance","sn
RNP Assembly","Toll-like Receptor Cascades","Oncogenic MAPK signaling","Leishmania infection","Phase I - Functionalization of compounds","Signaling by PDGFR in disease","Mitotic G2-G2/M phases","Signa
ling by WNT in cancer","Signaling by NOTCH1 in Cancer","GPCR downstream signalling","Generic Transcription Pathway","Signaling by VEGF","PIP3 activates AKT signaling","Caspase activation via extrinsic
 apoptotic signalling pathway","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","EPH-Ephrin signaling","Toll Like Receptor 5 (TLR5) Cascade","Signaling by RAS mutants","Parasite infectio
n","Cytochrome P450 - arranged by substrate type","Drug resistance of PDGFR mutants","G2/M Transition","Signaling by AMER1 mutants","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","G alpha (q) 
signalling events","Transcriptional Regulation by TP53","VEGFA-VEGFR2 Pathway","Negative regulation of the PI3K/AKT network","Caspase activation via Dependence Receptors in the absence of ligand","Sig
nalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis","EPHB-mediated forward signaling","MyD88 cascade initiated on plasma membrane","Signaling downstream of RAS mutants","L
eishmania phagocytosis",Xenobiotics,"Imatinib-resistant PDGFR mutants","Centrosome maturation","Truncations of AMER1 destabilize the destruction complex","Constitutive Signaling by NOTCH1 HD+PEST Doma
in Mutants","Gastrin-CREB signalling pathway via PKC and MAPK","Regulation of TP53 Activity","VEGFR2 mediated cell proliferation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signalling to RAS","
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Nef and signal transduction","Prolonged ERK activation events","MAP kinase activation","FCGR3A-mediated
 phagocytosis","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","EGFR Transactivation by Gastrin","Aromatic amines can be N-hydroxylated or N-
dealkylated by CYP1A2","Regulation of TP53 Activity through Phosphorylation","p38MAPK events","Nef Mediated CD4 Down-regulation","Frs2-mediated activation","activated TAK1 mediates p38 MAPK activation
","MAPK targets/ Nuclear events mediated by MAP kinases","Loss of Nlp from mitotic centrosomes","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{ABL1,LCK,RIPK2,SRC}

> <broad_moa>
{"SRC inhibitor"}

> <synonyms>
{172889-27-9,172889279,pp2,"PP 2","1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1(tertbutyl)3(4chlorophenyl)1Hpyrazolo(3,4d)pyrimidin4amine","AG 1879","1-tert-butyl-3-(4-chl
orophenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1tertbutyl3(4chlorophenyl)1Hpyrazolo(3,4d)pyrimidin4amine","1-tert-butyl-3-(4-chlorophenyl)pyrazolo(3,4-d)pyrimidin-4-amine","1tertbutyl3(4chlorophenyl
)pyrazolo(3,4d)pyrimidin4amine","AGL 1879",T6266,EI-297,1407,S7008,PP2}

> <pdid>
PD010654

> <targets>
{Src,"Src family"}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{4878}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    2.6531  -10.0886    0.0000 C   0  0
    1.1844   -9.7837    0.0000 N   0  0
    0.1863  -10.9034    0.0000 C   0  0
    0.7130   -8.3588    0.0000 C   0  0
   -0.7552   -8.0517    0.0000 C   0  0
   -1.2234   -6.6267    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
    1.2449   -5.8157    0.0000 C   0  0
    1.7131   -7.2408    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 11  1  0
 20 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28268

> <plate>
Kinase v5-1

> <well>
E06

> <supplier_cmpd_name>
SU 4312

> <ctcr_id>
3578

> <supplier_cmpd_id>
1459

> <smiles>
CN(C)c1ccc(cc1)C=C2C(=O)Nc3ccccc23

> <pd_targets>
{CSF1R,APP,FLT1,MAPT,GMNN,LMNA,RAB9A,SNCA,NPC1,PDGFRB,KMT2A,MEN1,ALDH1A1,FFP,FTL,NPSR1,HPGD,SMN1,RORC,MAPK1,BLM,NFO,PMP22,MTOR,EPHB2,PKM,THPO,CYP1A2,AMPC,CTRC,PYK,LEF,CHRM1,CYP3A4,CYP2C9,TSHR,TP53,CYP
2D6,KDR,CYP2C19}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Other cytosolic protein","Unclassified protein","Other nuclear protein",Transporter,"Epigenetic regulator","Transcription factor",Kinase,Oxidoreductase,Hydrolase,Reader,Tr
ansferase,"Family A G protein-coupled receptor","Nuclear receptor","Protein Kinase",Bromodomain,"Peptide receptor (family A GPCR)","Methyl-lysine/arginine binding protein","Nuclear hormone receptor su
bfamily 1","TK protein kinase group","Short peptide receptor (family A GPCR)","Tudor domain","Nuclear hormone receptor subfamily 1 group F","CMGC protein kinase group","Atypical protein kinase group",
"Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","Neuropeptide receptor","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase MAPK family","Atypica
l protein kinase PIKK family","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","Cytochrome P450",Protease,"Cytochrome P450 family 1","Serine protease","Metallo protease","Small mole
cule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Cytochrome P450 family 1A","Serine protease PA clan","Metallo protease MAE clan","Monoamine receptor","Cytochrome 
P450 family 3A","Cytochrome P450 family 2C","Glycohormone receptor","Cytochrome P450 family 2D","Tyrosine protein kinase Eph family","Cytochrome P450 1A1","Serine protease S1A subfamily","Metallo prot
ease M34 family","Acetylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 2C9","Cytochrome P450 2D6","Cytochrome P450 2C19"}

> <pathway_chembl>
{Receptors,Transporters,Enzymes,"Catalytic receptors","SLC superfamily of solute carriers","G protein-coupled receptors","Eicosanoid turnover","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Recep
tor kinases","SLC65 NPC-type cholesterol transporters","Neuropeptide S receptor","Prostaglandin synthases","1F. Retinoic acid-related orphans","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,
"TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Receptor tyrosine kinases (RTKs)","ERK subfamily","FRAP subfami
ly","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","2.7.1.40 Pyruvate kinases","Cytochrome P450","Peptidases and prote
inases","CYP1 family","PA: Serine (S) Peptidases","Acetylcholine receptors (muscarinic)","CYP3 family","CYP2 family: drug metabolising subset","Glycoprotein hormone receptors","S1: Chymotrypsin","Type
 XIII RTKs: Ephrin receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System","Signal Transduction","Neuronal System","Cell Cycle","Metabolism of proteins","Transport of small molecules",Metabolism,"Vesicle-mediated transport",
Disease,"Metabolism of RNA","DNA Repair","Developmental Biology","RNA Polymerase II Transcription","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Transmission across Chemical Synapse
s",Mitotic,"Signaling by Rho GTPases","Amyloid fiber formation","Plasma lipoprotein assembly",remodeling,"and clearance","Intracellular signaling by second messengers","Biological oxidations","Membran
e Trafficking","Infectious disease","Metabolism of lipids","Metabolism of non-coding RNA","DNA Double-Strand Break Repair","Nervous system development","Generic Transcription Pathway","Toll-like Recep
tor Cascades","Signaling by VEGF","Neurotransmitter receptors and postsynaptic signal transmission","Mitotic G1 phase and G1/S transition","M Phase","Rho GTPase cycle","Plasma lipoprotein clearance","
PIP3 activates AKT signaling","Phase I - Functionalization of compounds","trans-Golgi Network Vesicle Budding","Leishmania infection","Biosynthesis of specialized proresolving mediators (SPMs)","snRNP
 Assembly","Homology Directed Repair","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Transcriptional Regulation by VENTX","Toll Like Receptor 5 (TLR5) Cascade","VEGF ligand-receptor
 interactions","Activation of NMDA receptors and postsynaptic events","G1/S Transition","Mitotic Metaphase and Anaphase","RHOBTB GTPase Cycle","LDL clearance","Negative regulation of the PI3K/AKT netw
ork","Ethanol oxidation","Golgi Associated Vesicle Biogenesis","Leishmania parasite growth and survival","Biosynthesis of DHA-derived SPMs","Transcriptional regulation by RUNX3","HDR through Homologou
s Recombination (HRR) or Single Strand Annealing (SSA)","Transcriptional Regulation by TP53","MyD88 cascade initiated on plasma membrane","VEGF binds to VEGFR leading to receptor dimerization","Post N
MDA receptor activation events","Activation of the pre-replicative complex","Mitotic Anaphase","RHOBTB3 ATPase cycle",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Anti-inflammatory response favou
ring Leishmania parasite infection","Biosynthesis of D-series resolvins","RUNX3 Regulates Immune Response and Cell Migration","HDR through Homologous Recombination (HRR)","Regulation of TP53 Activity"
,"TAK1 activates NFkB by phosphorylation and activation of IKKs complex","Activation of AMPK downstream of NMDARs","Nuclear Envelope (NE) Reassembly","ADORA2B mediated anti-inflammatory cytokines prod
uction","MAP kinase activation","Homologous DNA Pairing and Strand Exchange","Regulation of TP53 Expression and Degradation","Initiation of Nuclear Envelope (NE) Reformation","MAPK targets/ Nuclear ev
ents mediated by MAP kinases","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation","ERK/MAPK targets","ERKs are inactivated",Hemostasis,"Metabolism of car
bohydrates","Platelet activation","signaling and aggregation","Metabolism of vitamins and cofactors","Signaling by GPCR","Cell Cycle Checkpoints","Axon guidance","Glucose metabolism","Platelet Aggrega
tion (Plug Formation)","Metabolism of water-soluble vitamins and cofactors","Uptake and actions of bacterial toxins","GPCR ligand binding","G1/S DNA Damage Checkpoints","EPH-Ephrin signaling",Glycolys
is,"Cytochrome P450 - arranged by substrate type","Cobalamin (Cbl","vitamin B12) transport and metabolism","Uptake and function of anthrax toxins","Class A/1 (Rhodopsin-like receptors)","p53-Dependent
 G1/S DNA damage checkpoint","VEGFA-VEGFR2 Pathway","EPHB-mediated forward signaling",Xenobiotics,"Amine ligand-binding receptors","Biosynthesis of maresins","p53-Dependent G1 DNA Damage Response","VE
GFR2 mediated cell proliferation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","Stabil
ization of p53","Autodegradation of the E3 ubiquitin ligase COP1"}

> <broad_targets>
{KDR,PDGFRB}

> <broad_moa>
{"PDGFR tyrosine kinase receptor inhibitor","tyrosine kinase inhibitor","VEGFR inhibitor"}

> <synonyms>
{SU4312,3-(4-dimethylamino-benzylidenyl)-2-indolinone,3(4dimethylaminobenzylidenyl)2indolinone,5812-07-7,5812077,3-((4-(dimethylamino)phenyl)methylidene)-1H-indol-2-one,3((4(dimethylamino)phenyl)methy
lidene)1Hindol2one,dmbi,KBioGR_000338,KBioGR000338,KBioGR-000338,"KBioGR 000338",KBioSS_000338,KBioSS000338,KBioSS-000338,"KBioSS 000338",CHEBI:92369,KBio2_000338,KBio2000338,KBio2-000338,"KBio2 00033
8",KBio2_002906,KBio2002906,KBio2-002906,"KBio2 002906",KBio2_005474,KBio2005474,KBio2-005474,"KBio2 005474",KBio3_000675,KBio3000675,KBio3-000675,"KBio3 000675",KBio3_000676,KBio3000676,KBio3-000676,
"KBio3 000676",Bio2_000339,Bio2000339,Bio2-000339,"Bio2 000339",Bio2,"EMD 317200",EI-306,1459,317200,"SU 4312"}

> <pdid>
PD015018

> <targets>
{VEGFR,Flk1}

> <classes>
{}

> <pubchem_cids>
{3135}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 20  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.1471   -2.9705    0.0000 N   0  0
   -4.6471   -2.9705    0.0000 N   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  7  1  0
 15 10  1  0
 14 16  1  0
 16  4  1  0
 16 17  2  0
M  END
> <name>
UTKinase_V5

> <id>
28269

> <plate>
Kinase v5-1

> <well>
E08

> <supplier_cmpd_name>
SP 600125

> <ctcr_id>
11925

> <supplier_cmpd_id>
1496

> <smiles>
c1ccc2c(c1)c1n[nH]c3cccc(c13)c2=O

> <pd_targets>
{MAPK10,MAPK9,MAPK8,EIF2AK2,TTK,JAK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","TK protein kinase group","CMGC protein kinase MAPK family","Other protein kinase PEK family","Other protein ki
nase TTK family","Tyrosine protein kinase JakA family","CMGC protein kinase JNK subfamily","Other protein kinase PKR"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Mitogen-activated protein kinases (MAP kinases)","Other protein kina
ses","TK: Tyrosine kinase","JNK subfamily","PEK family","TTK family","Non-receptor tyrosine kinases (nRTKs)","Other PEK family kinases","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Immune System",Disease,"Innate Immune System","Infectious disease","Cytokine Signaling in Immune system","Toll-like Receptor Cascades","Influenza Infection","Signaling by Interleukins","Toll Like Re
ceptor 5 (TLR5) Cascade","NS1 Mediated Effects on Host Pathways","Interleukin-2 family signaling","MyD88 cascade initiated on plasma membrane","Inhibition of PKR","Interleukin-15 signaling","MAP kinas
e activation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{129-56-6,129566,"1,9-Pyrazoloanthrone","1,9Pyrazoloanthrone",SP600125,Pyrazolanthrone,"Dibenzo(cd,g)indazol-6(2H)-one","Dibenzo(cd,g)indazol6(2H)one",Pyrazoleanthrone,"SP 600125","Anthra(1,9-cd)pyraz
ol-6(2H)-one","Anthra(1,9cd)pyrazol6(2H)one",SP-600125,"Anthra-1,9-pyrazol-6-none","Anthra1,9pyrazol6none","JNK Inhibitor II",2H-Dibenzo(cd,2HDibenzo(cd,g)indazol-6-on,g)indazol6on,T3109}

> <pdid>
PD002737

> <targets>
{JNK,"Aurora A",JNK1,JNK2,JNK3,TrkA}

> <classes>
{"Cell Cycle/Checkpoint",MAPK,"Tyrosine Kinase/Adaptors",Chromatin/Epigenetic}

> <pubchem_cids>
{8515}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  1  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    1.2873   -5.2494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    3.9072    5.2405    0.0000 C   0  0
    3.9020    3.7405    0.0000 C   0  0
    5.1985    2.9860    0.0000 Cl  0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  1
  5  6  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 12  1  0
 10 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 22 26  1  0
 26 19  1  0
 26 27  2  0
 27  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28270

> <plate>
Kinase v5-1

> <well>
E10

> <supplier_cmpd_name>
Purvalanol A

> <ctcr_id>
7683

> <supplier_cmpd_id>
1580

> <smiles>
CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1

> <pd_targets>
{KMT2A,MEN1,STAT6,CDK1,MAPK3,SRC,CDK2,CDK4,CCNA1,CCNA2,CCND1,CDC28,CDK5,CDK5R1,MAPK1,MAPT,CYP1A2,PAK4,CCNE1,CCNE2,DYRK1A,LEF,CYP3A4,CYP2D6,INSR,KDM4E,HIF1A,CCNB1,TSHR,RORC,PFMRK,HSD17B10,CYP2C9,CCNB2,
CCNB3,PRKACA,PRKACB,PRKACG,CYP2C19,ALDH1A1}

> <pathway_gtopdb>
{"Epigenetic regulator","Transcription factor",Enzyme,"Other cytosolic protein","Membrane receptor",Reader,Kinase,"Cytochrome P450",Protease,Eraser,"Family A G protein-coupled receptor","Nuclear recep
tor",Oxidoreductase,Bromodomain,"Protein Kinase","Cytochrome P450 family 1","Metallo protease","Cytochrome P450 family 3","Cytochrome P450 family 2","Lysine demethylase","Peptide receptor (family A GP
CR)","Nuclear hormone receptor subfamily 1","Cysteine protease","CMGC protein kinase group","TK protein kinase group","Cytochrome P450 family 1A","STE protein kinase group","Metallo protease MAE clan"
,"Cytochrome P450 family 3A","Cytochrome P450 family 2D","Jumonji domain-containing","Glycohormone receptor","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 2C","AGC protein kin
ase group","Cysteine protease CA clan","CMGC protein kinase CDK family","CMGC protein kinase MAPK family","Tyrosine protein kinase Src family","Cytochrome P450 1A1","STE protein kinase STE20 family","
CMGC protein kinase DYRK family","Metallo protease M34 family","Cytochrome P450 3A4","Cytochrome P450 2D6","Tyrosine protein kinase InsR family","Nuclear hormone receptor subfamily 1 group F member 3"
,"Cytochrome P450 2C9","AGC protein kinase PKA family","Cysteine protease C1A family","Cytochrome P450 2C19","CMGC protein kinase CDC2 subfamily","CMGC protein kinase ERK1","CMGC protein kinase CDK2",
"STE protein kinase PAKB subfamily","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{"Other protein targets",Enzymes,Receptors,"Transcription factors","Kinases (EC 2.7.x.x)","Catalytic receptors","Cytochrome P450","Chromatin modifying enzymes","G protein-coupled receptors","Nuclear h
ormone receptors","STAT transcription factors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CYP1 family","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CY
P3 family","CYP2 family: drug metabolising subset","1.14.11.- Histone demethylases","Glycoprotein hormone receptors","1F. Retinoic acid-related orphans","Cyclin-dependent kinase (CDK) family","Mitogen
-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","STE20 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CDK1 subfamily","ERK subfamily","Non-rece
ptor tyrosine kinases (nRTKs)","CDK4 subfamily","PAKB subfamily","Dyrk1 subfamily","CDK5 subfamily","Receptor tyrosine kinases (RTKs)","Src family","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Immune System","Cell Cycle","Signal Transduction","Gene expression (Transcription)","Neuronal System",Metabolism,"Developmental Biology",Disease,"Cellular responses to external stimuli","Innate Immu
ne System",Mitotic,"Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Transmission across Chemical Synapses","Biological oxidations","Nervous system development","Infectious d
isease","Metabolism of lipids","Intracellular signaling by second messengers","Cellular responses to stress","Metabolism of amino acids and derivatives","Cytosolic sensors of pathogen-associated DNA",
"Regulation of mitotic cell cycle","Toll-like Receptor Cascades","Signaling by NTRKs","Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","Neurotransmitter receptors and postsynapti
c signal transmission","Phase I - Functionalization of compounds","Axon guidance","Uptake and actions of bacterial toxins","Biosynthesis of specialized proresolving mediators (SPMs)","PIP3 activates A
KT signaling","Cellular response to hypoxia","Leishmania infection","Branched-chain amino acid catabolism","STING mediated induction of host immune responses","APC/C-mediated degradation of cell cycle
 proteins","Toll Like Receptor 5 (TLR5) Cascade","Signaling by NTRK1 (TRKA)","Transcriptional Regulation by TP53","G1 Phase","Activation of NMDA receptors and postsynaptic events","Cytochrome P450 - a
rranged by substrate type","Signaling by ROBO receptors","G0 and Early G1","Uptake and function of anthrax toxins","Biosynthesis of DHA-derived SPMs","Negative regulation of the PI3K/AKT network","Oxy
gen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Leishmania parasite growth and survival","Transcriptional regulation by RUNX3","Ethanol oxidation","STAT6-mediated induction of 
chemokines","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","MyD88 cascade initiated on plasma membrane","Signalling to ERKs","Regulation of TP53 Activity","Cyclin D ass
ociated events in G1","Post NMDA receptor activation events",Xenobiotics,"Activation of RAC1","Biosynthesis of maresins",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Anti-inflammatory response fa
vouring Leishmania parasite infection","RUNX3 Regulates Immune Response and Cell Migration","APC/C:Cdc20 mediated degradation of mitotic proteins","MAP kinase activation","Signalling to RAS","Regulati
on of TP53 Expression and Degradation","Activation of AMPK downstream of NMDARs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Regulation of TP53 Activity through Phosphorylation
","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","ADORA2B mediated anti-inflammatory cytokines production","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the ce
ll cycle checkpoint","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","Regulation of TP53 Degradation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERK/MAPK targets",
"ERKs are inactivated"}

> <broad_targets>
{CDK1,CDK2,CDK4,CDK5,CSNK1G3,RPS6KA1,SRC}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{"purvalanol A",212844-53-6,212844536,Purv,2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine,2(1RIsopropyl2hydroxyethylamino)6(3chloroanilino)9isopropylpurine,6-((3-chloro)ani
lino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine,6((3chloro)anilino)2(isopropyl2hydroxyethylamino)9isopropylpurine,CHEMBL23327,UNII-YP483E75C4,UNIIYP483E75C4,NG-60,NG60,CHEBI:47600,"NG 60",YP
483E75,1580,"Purvalanol A"}

> <pdid>
PD006424

> <targets>
{cdk}

> <classes>
{}

> <pubchem_cids>
{456214}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 32  0  0  1  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    1.2873   -5.2494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    3.9072    5.2405    0.0000 C   0  0
    5.2080    5.9891    0.0000 C   0  0
    6.5058    5.2368    0.0000 O   0  0
    5.2111    7.4890    0.0000 O   0  0
    3.9020    3.7405    0.0000 C   0  0
    5.1985    2.9860    0.0000 Cl  0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  1
  5  6  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 15 19  1  0
 19 20  1  0
 19 21  2  0
 21 12  1  0
 10 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 26 28  1  0
 25 29  1  0
 29 22  1  0
 29 30  2  0
 30  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28271

> <plate>
Kinase v5-1

> <well>
E12

> <supplier_cmpd_name>
Purvalanol B

> <ctcr_id>
7684

> <supplier_cmpd_id>
1581

> <smiles>
CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c3ncn(C(C)C)c3n1

> <pd_targets>
{CDK2,NTRK2,MAPK3,PRKACA,PRKACB,PRKACG,KDM4E,NTRK1,CCNB1,CCNB2,CCNB3,CDK1,CCNA1,CCNA2,CCNE1,CCNE2,INSR,CDK4,CDK5,CDK5R1,CDC28,ALDH1A1,MAPK1}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Eraser,Oxidoreductase,"Protein Kinase","Lysine demethylase","CMGC protein kinase group","TK protein kinase group","AGC protein kinase group","Jumonji domain-conta
ining","CMGC protein kinase CDK family","Tyrosine protein kinase Trk family","CMGC protein kinase MAPK family","AGC protein kinase PKA family","Tyrosine protein kinase InsR family","CMGC protein kinas
e CDC2 subfamily","CMGC protein kinase ERK1","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK2"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Chromatin modifying enzymes","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","1.14.11.- Histone demethylases","Cycli
n-dependent kinase (CDK) family","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","CDK1 subfamily","Receptor tyrosine kinases (RTKs)","ERK subfamily","CDK4 subfamily","CDK5 subf
amily","Type VII RTKs: Neurotrophin receptor/Trk family","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Immune System","Cell Cycle",Metabolism,"RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Intr
acellular signaling by second messengers",Mitotic,"Biological oxidations","Generic Transcription Pathway","Signaling by NTRKs","Toll-like Receptor Cascades","PIP3 activates AKT signaling","Mitotic G1 
phase and G1/S transition","Regulation of mitotic cell cycle","Phase I - Functionalization of compounds","Transcriptional Regulation by TP53","Signaling by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) C
ascade","Negative regulation of the PI3K/AKT network","G1 Phase","APC/C-mediated degradation of cell cycle proteins","Ethanol oxidation","Regulation of TP53 Activity","Activation of TRKA receptors","M
yD88 cascade initiated on plasma membrane","Signalling to ERKs",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Cyclin D associated events in G1","Activation of APC/C and APC/C:Cdc20 mediated degrad
ation of mitotic proteins","Regulation of TP53 Expression and Degradation","NGF-independant TRKA activation","MAP kinase activation","Prolonged ERK activation events","Regulation of TP53 Activity thro
ugh Phosphorylation","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","APC:Cdc2
0 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CDK2,CDK4,CDK5,MAPK1,MAPK3,SRPK2}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{"Purvalanol B",212844-54-7,212844547,PURVALANOL,"NG 95","Purvalanol B(NG-95)","Purvalanol B(NG95)",CHEMBL23254,CHEBI:49840,NG-95,NG95,MFCD04118312,C20H25ClN6O3,purvalanol-B,purvalanolB,Tocris-1581,To
cris1581,1v0p,"Purvalanol B(NG 95)",SCHEMBL27951,BDBM7478,GTPL7806,EX-A354,EXA354,SYN1070,HMS3268E21,HMS3,1581}

> <pdid>
PD007682

> <targets>
{cdk}

> <classes>
{}

> <pubchem_cids>
{448991}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 31  0  0  0  0            999 V2000
    3.8919   -5.2525    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 O   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 S   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -3.8971   -5.2500    0.0000 C   0  0
   -2.5980   -6.0000    0.0000 C   0  0
   -1.2990   -5.2500    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 S   0  0
    0.0000   -1.5000    0.0000 C   0  0
    6.4978   -0.7562    0.0000 N   0  0
    7.7969   -1.5062    0.0000 C   0  0
    9.0960   -0.7561    0.0000 C   0  0
    9.0959    0.7439    0.0000 O   0  0
    7.7969    1.4938    0.0000 C   0  0
    6.4979    0.7438    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  2  3
  7  2  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 21  8  1  0
 21 12  2  0
  4 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28272

> <plate>
Kinase v5-1

> <well>
E14

> <supplier_cmpd_name>
KU 55933

> <ctcr_id>
4896

> <supplier_cmpd_id>
3544

> <smiles>
O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5

> <pd_targets>
{PIK3CB,ATM,PRKDC,PIK3CA,MTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Other PIKK f
amily kinases","FRAP subfamily"}

> <pathway_reactome>
{"Signal Transduction","Cell Cycle","Immune System",Disease,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Cell Cycle Checkpoints","Innate Immune System","Diseases of sign
al transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Signaling by Insulin receptor","G1/S DNA Damage Checkpoints","Cytosolic sensors of pathogen-associa
ted DNA","Signaling by FGFR in disease","Generic Transcription Pathway","Insulin receptor signalling cascade","p53-Dependent G1/S DNA damage checkpoint","STING mediated induction of host immune respon
ses","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","IRS-mediated signalling","p53-Dependent G1 DNA Damage Response","IRF3-mediated induction of type I IFN","FGFR1 mutant recepto
r activation","Regulation of TP53 Activity","PI3K Cascade","Stabilization of p53","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation","Autodegradation of the 
E3 ubiquitin ligase COP1","Regulation of TP53 Degradation"}

> <broad_targets>
{ATM,PRKDC}

> <broad_moa>
{"ATM kinase inhibitor"}

> <synonyms>
{KU-55933,KU55933,587871-26-9,587871269,"ATM Kinase Inhibitor",2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one,2Morpholino6(thianthren1yl)4Hpyran4one,"KU 55933",2-Morpholin-4-yl-6-thianthren-1-ylpyran
-4-one,2Morpholin4yl6thianthren1ylpyran4one,2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one,"KU-55933 (ATM Kinase Inhibitor)","KU55933 (ATM Kinase Inhibitor)",UNII-O,UNIIO,T2685,S1092,"EMD 118500","Se 
S1092",3544,118500}

> <pdid>
PD003488

> <targets>
{ATM,"ATM Inhibitors"}

> <classes>
{}

> <pubchem_cids>
{5278396}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
    7.7858   -9.1806    0.0000 N   0  0
    6.3110   -8.9071    0.0000 C   0  0
    5.3370  -10.0479    0.0000 O   0  0
    5.8106   -7.4921    0.0000 C   0  0
    6.7829   -6.3499    0.0000 C   0  0
    6.2798   -4.9368    0.0000 C   0  0
    4.8092   -4.6676    0.0000 C   0  0
    3.8322   -5.8080    0.0000 C   0  0
    4.3352   -7.2212    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 O   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 12 19  2  0
 19 20  1  0
 20 10  2  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 24  1  0
 28 29  2  0
 29 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28273

> <plate>
Kinase v5-1

> <well>
E16

> <supplier_cmpd_name>
SB 431542

> <ctcr_id>
284

> <supplier_cmpd_id>
1614

> <smiles>
NC(=O)c1ccc(cc1)c2[nH]c(c3ccccn3)c(n2)c4ccc5OCOc5c4

> <pd_targets>
{CYP1A2,TGFBR1,RIPK2,ALDH1A1,ACVR1B,CSNK1E,PRKD3,CYP2C19,IMPA1,CYP2D6,MAPK14,CYP3A4,CSNK1D,CSNK1A1L,MAPK1,KDM4E,LEF,MAPT,HPGD,HSD17B10,CSNK1A1,RPS6KA1,TGFBR2,ACVR1C}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Cytochrome P450",Kinase,Oxidoreductase,Hydrolase,Eraser,Protease,"Cytochrome P450 family 1","Protein Kinase","Cytochrome P450 family 2","Cytoc
hrome P450 family 3","Lysine demethylase","Metallo protease","Cytochrome P450 family 1A","TKL protein kinase group","CK1 protein kinase group","CAMK protein kinase group","Cytochrome P450 family 2C","
Cytochrome P450 family 2D","CMGC protein kinase group","Cytochrome P450 family 3A","Jumonji domain-containing","Metallo protease MAE clan","AGC protein kinase group","Cytochrome P450 1A1","TKL protein
 kinase STKR family","TKL protein kinase RIPK family","CK1 protein kinase CK1 family","CAMK protein kinase PKD family","Cytochrome P450 2C19","Cytochrome P450 2D6","CMGC protein kinase MAPK family","C
ytochrome P450 3A4","Metallo protease M34 family","AGC protein kinase RSK family","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase p38 subfamily","CK1 protein kinase CK1-a","CMGC protei
n kinase ERK1","AGC protein kinase RSK subfamily","TKL protein kinase STKR Type 2 subfamily","TKL protein kinase STKR1"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Catalytic receptors","Kinases (EC 2.7.x.x)","Inositol phosphate turnover","Chromatin modifying enzymes","Eicosanoid turnover","CYP1 family","Receptor kinases","CK
1: Casein kinase 1","CAMK: Calcium/calmodulin-dependent protein kinases","CYP2 family: drug metabolising subset","Inositol monophosphatase","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP3 family
","1.14.11.- Histone demethylases","Prostaglandin synthases","AGC: Containing PKA",PKG,"PKC families","TKL: Tyrosine kinase-like","Casein kinase 1 (CK1) family","Protein kinase D (PKD) family","Mitoge
n-activated protein kinases (MAP kinases)","RSK family","Receptor serine/threonine kinase (RSTK) family","Receptor interacting protein kinase (RIPK) family","p38 subfamily","ERK subfamily","RSK subfam
ily","Type I receptor serine/threonine kinases","Type II receptor serine/threonine kinases"}

> <pathway_reactome>
{Metabolism,Disease,"Immune System","Developmental Biology","Cell Cycle","Neuronal System","Biological oxidations","Diseases of signal transduction by growth factor receptors and second messengers","I
nnate Immune System","Signaling by NODAL",Mitotic,"Metabolism of lipids","Inositol phosphate metabolism","Infectious disease","Transmission across Chemical Synapses","Metabolism of amino acids and der
ivatives","Phase I - Functionalization of compounds","Signaling by TGF-beta Receptor Complex in Cancer","Toll-like Receptor Cascades","Regulation of signaling by NODAL","Mitotic G2-G2/M phases","Sphin
golipid metabolism","Synthesis of IP2",IP,"and Ins in the cytosol","Biosynthesis of specialized proresolving mediators (SPMs)","Uptake and actions of bacterial toxins","Neurotransmitter receptors and 
postsynaptic signal transmission","Branched-chain amino acid catabolism","Signaling by WNT in cancer","Cytochrome P450 - arranged by substrate type","Loss of Function of SMAD2/3 in Cancer","Toll Like 
Receptor 5 (TLR5) Cascade","Ethanol oxidation","G2/M Transition","Sphingolipid de novo biosynthesis","Biosynthesis of DHA-derived SPMs","Uptake and function of anthrax toxins","Activation of NMDA rece
ptors and postsynaptic events","Signaling by AMER1 mutants",Xenobiotics,"SMAD2/3 Phosphorylation Motif Mutants in Cancer","MyD88 cascade initiated on plasma membrane","Centrosome maturation","Biosynth
esis of maresins","Post NMDA receptor activation events","Biosynthesis of D-series resolvins","Truncations of AMER1 destabilize the destruction complex","Aromatic amines can be N-hydroxylated or N-dea
lkylated by CYP1A2","MAP kinase activation","Loss of proteins required for interphase microtubule organization from the centrosome","CYP2E1 reactions","Biosynthesis of maresin-like SPMs","Activation o
f AMPK downstream of NMDARs","activated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family 
of transcription factors","ERK/MAPK targets","CREB phosphorylation","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{301836-41-9,301836419,SB-431542,SB431542,"SB 431542","4-(4-(benzo(d)(1,3)dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide","4(4(benzo(d)(1,3)dioxol5yl)5(pyridin2yl)1Himidazol2yl)benzamide",UN
II-E1557V1V0N,UNIIE1557V1V0N,"4-(4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL)BENZAMIDE","4(4(1,3BENZODIOXOL5YL)5(2PYRIDINYL)1HIMIDAZOL2YL)BENZAMIDE","SB 431542 hydrate",CHEMBL440084,T172
6,S1067,1614}

> <pdid>
PD003368

> <targets>
{TGF-beta,"TGF-beta Inhibitors",TGFbR1}

> <classes>
{}

> <pubchem_cids>
{4521392}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.3342   -4.5421    0.0000 C   0  0
    6.4049   -6.0405    0.0000 C   0  0
    5.1427   -6.8509    0.0000 C   0  0
    5.2134   -8.3492    0.0000 Cl  0  0
    3.8097   -6.1630    0.0000 C   0  0
    3.7390   -4.6647    0.0000 C   0  0
    2.4063   -3.9763    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10  5  1  0
  4 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 12 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 18  1  0
 24 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28274

> <plate>
Kinase v5-1

> <well>
E18

> <supplier_cmpd_name>
SB 216763

> <ctcr_id>
5668

> <supplier_cmpd_id>
1616

> <smiles>
Cn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4ccc(Cl)cc4Cl

> <pd_targets>
{CCNA1,CCNA2,CDK2,MAPK1,CCNB1,CCNB2,CCNB3,CDK1,NFO,THPO,USP2,GMNN,GSK3B,MAPT,CYP2C19,MEX-5,ALD,HTT,HBB,GSK3A,KMT2A,MEN1,NFKB1,APEX1,HIF1A,CYP3A4,CYP2C9,LMNA,RORC,POLB,CCND1,CDK4,RECQL,FTL,CYP1A2,LEF,C
YP2D6,POS-1,PAX8}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Other cytosolic protein","Transcription factor","Secreted protein","Epigenetic regulator","Other nuclear protein",Kinase,Hydrolase,Protease,"Cytochrome P450",Reader,"Nu
clear receptor","Protein Kinase","Cysteine protease","Cytochrome P450 family 2",Bromodomain,"Cytochrome P450 family 3","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 1","Metallo protea
se","CMGC protein kinase group","Cysteine protease CA clan","Cytochrome P450 family 2C","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 1A","Metallo 
protease MAE clan","Cytochrome P450 family 2D","CMGC protein kinase CDK family","CMGC protein kinase MAPK family","Cysteine protease C19 family","CMGC protein kinase GSK family","Cytochrome P450 2C19"
,"Cytochrome P450 3A4","Cytochrome P450 2C9","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 1A1","Metallo protease M34 family","Cytochrome P450 2D6","CMGC protein kinase CDC2
 subfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Peptidases and proteinases","Cytochrome P450","Chromatin modifying enzymes","Nuclear hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CA: 
Cysteine (C) Peptidases","CYP2 family: drug metabolising subset","CYP3 family","2.1.1.43 Histone methyltransferases (HMTs)","1F. Retinoic acid-related orphans","CYP1 family","Mitogen-activated protein
 kinases (MAP kinases)","C19: Ubiquitin-specific protease","Glycogen synthase kinase (GSK) family","ERK subfamily","GSK subfamily"}

> <pathway_reactome>
{"Immune System",Hemostasis,"Gene expression (Transcription)","Cell Cycle",Disease,"Neuronal System",Metabolism,"DNA Repair","Cellular responses to external stimuli","Vesicle-mediated transport","Inna
te Immune System","Platelet activation","signaling and aggregation","RNA Polymerase II Transcription",Mitotic,"Infectious disease","Transmission across Chemical Synapses","Biological oxidations","Cyto
kine Signaling in Immune system","Base Excision Repair","Cellular responses to stress","Metabolism of lipids","Membrane Trafficking","Toll-like Receptor Cascades","Platelet Aggregation (Plug Formation
)","Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","SARS-CoV Infections","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization of compou
nds","Neutrophil degranulation","Signaling by Interleukins","Resolution of Abasic Sites (AP sites)","Cellular response to hypoxia","Biosynthesis of specialized proresolving mediators (SPMs)","M Phase"
,"trans-Golgi Network Vesicle Budding","Uptake and actions of bacterial toxins","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional Regulation by TP53","G1/S Transition","SARS-CoV-1 Infection","Act
ivation of NMDA receptors and postsynaptic events","Cytochrome P450 - arranged by substrate type","Transcriptional Regulation by MECP2","Interleukin-1 family signaling","Resolution of AP sites via the
 multiple-nucleotide patch replacement pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Biosynthesis of DHA-derived SPMs","Mitotic Metaphase and Anaphase","Transcri
ptional regulation by RUNX1","Transcriptional regulation by RUNX3","Golgi Associated Vesicle Biogenesis","Uptake and function of anthrax toxins","MyD88 cascade initiated on plasma membrane","Regulatio
n of TP53 Activity","Activation of the pre-replicative complex","SARS-CoV-1 Genome Replication and Transcription","Post NMDA receptor activation events",Xenobiotics,"Regulation of MECP2 expression and
 activity","Interleukin-1 signaling","PCNA-Dependent Long Patch Base Excision Repair","Biosynthesis of maresins","Mitotic Anaphase","RUNX1 regulates genes involved in megakaryocyte differentiation and
 platelet function","RUNX3 Regulates Immune Response and Cell Migration","MAP kinase activation","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-1 genome","Activation of A
MPK downstream of NMDARs","CYP2E1 reactions","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of maresin-like SPMs","Nuclear Envelope (NE) Reassembly","Aromatic amines can be N-hydroxylated 
or N-dealkylated by CYP1A2","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Initiation of Nuclear Envelope (NE) Reformation","ERK/MAPK targets","ERKs are inact
ivated"}

> <broad_targets>
{CCNA2,CDK2,GSK3A,GSK3B}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{280744-09-4,280744094,"SB 216763","3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione","3(2,4Dichlorophenyl)4(1methyl1Hindol3yl)1Hpyrrole2,5dione",SB216763,SB-216763,"3-(2,4-dichl
orophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione","3(2,4dichlorophenyl)4(1methylindol3yl)pyrrole2,5dione",C19H12Cl2N2O2,1H-Pyrrole-2,1HPyrrole2,5-dione,5dione,3-(2,3(2,4-dichlorophenyl)-4-,4dichloro
phenyl)4,T3077,1616,S1075}

> <pdid>
PD002648

> <targets>
{GSK-3,GSK3}

> <classes>
{}

> <pubchem_cids>
{176158}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2526    1.3618    0.0000 C   0  0
   -6.2524    0.2436    0.0000 C   0  0
   -7.7447    0.3952    0.0000 O   0  0
   -5.4979   -1.0529    0.0000 N   0  0
   -4.0317   -0.7359    0.0000 C   0  0
   -2.9076   -1.7290    0.0000 O   0  0
   -5.5610    2.8305    0.0000 C   0  0
   -7.0220    3.1784    0.0000 C   0  0
   -7.4458    4.6173    0.0000 C   0  0
   -6.4116    5.7038    0.0000 C   0  0
   -4.9536    5.3514    0.0000 C   0  0
   -4.5297    3.9126    0.0000 C   0  0
   -3.0706    3.5612    0.0000 N   0  3
   -2.6461    2.1225    0.0000 O   0  5
   -2.0366    4.6478    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12  7  1  0
 12 13  2  0
  8 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 20 22  2  0
  5 23  1  0
 23 24  2  0
 24  2  1  0
 24 25  1  0
M  CHG  2  20   1  21  -1
M  END
> <name>
UTKinase_V5

> <id>
28275

> <plate>
Kinase v5-1

> <well>
E20

> <supplier_cmpd_name>
SB 415286

> <ctcr_id>
2002

> <supplier_cmpd_id>
1617

> <smiles>
Oc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl

> <pd_targets>
{GSK3B,THPO,GSK3A,ALDH1A1,ALD,CHRM1,CYP3A4,DYRK1A,GAA,CYP2C9,NFKB1,MAPT,CYP2C19,NS1,BLM,LMNA,TGR,FFP,HPGD,RORC,POLB,GMNN,CYP1A2,CCNB1,CCNB2,CCNB3,CDK1,HSD17B10,PMP22,CCNA1,CCNA2,CDK2,KMT2A,MEN1,SMN1,T
SHR,HIF1A,CDK5,CDK5R1,FTL}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Membrane receptor","Other cytosolic protein","Other nuclear protein","Transcription factor","Epigenetic regulator",Kinase,Oxidoreductase,"Family A G protein-coupled rec
eptor","Cytochrome P450",Hydrolase,Transferase,"Nuclear receptor",Reader,"Protein Kinase","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Nuclear hormo
ne receptor subfamily 1","Cytochrome P450 family 1",Bromodomain,"Methyl-lysine/arginine binding protein","Peptide receptor (family A GPCR)","CMGC protein kinase group","Monoamine receptor","Cytochrome
 P450 family 3A","Cytochrome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 1A","Tudor domain","Glycohormone receptor","CMGC protein kinase GSK family","Acetylc
holine receptor","Cytochrome P450 3A4","CMGC protein kinase DYRK family","Cytochrome P450 2C9","Cytochrome P450 2C19","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 1A1","CMG
C protein kinase CDK family","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","G protein-coupled receptors","Cytochrome P450","3.2.1.- Glycosidases","Eicosanoid turnover","Nuclear hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK
 families","Acetylcholine receptors (muscarinic)","CYP3 family","CYP2 family: drug metabolising subset","Prostaglandin synthases","1F. Retinoic acid-related orphans","CYP1 family","Glycoprotein hormon
e receptors","Glycogen synthase kinase (GSK) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","GSK subfamily","Dyrk1 subfamily"}

> <pathway_reactome>
{Disease,Hemostasis,Metabolism,"Signal Transduction","Cell Cycle","Immune System","Neuronal System","DNA Repair","Gene expression (Transcription)","Developmental Biology","Metabolism of RNA","Cellular
 responses to external stimuli","Vesicle-mediated transport","Infectious disease","Platelet activation","signaling and aggregation","Biological oxidations","Signaling by GPCR","Metabolism of lipids",M
itotic,"Diseases of metabolism","Cytokine Signaling in Immune system","Transmission across Chemical Synapses","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Base Excision Repair",
"Metabolism of amino acids and derivatives","Nervous system development","Metabolism of non-coding RNA","Cellular responses to stress","Membrane Trafficking","SARS-CoV Infections","Platelet Aggregatio
n (Plug Formation)","Phase I - Functionalization of compounds","GPCR ligand binding","Biosynthesis of specialized proresolving mediators (SPMs)","Mitotic G1 phase and G1/S transition","Diseases of car
bohydrate metabolism","Signaling by Interleukins","Neurotransmitter receptors and postsynaptic signal transmission","Homology Directed Repair","M Phase","Generic Transcription Pathway","Resolution of 
Abasic Sites (AP sites)","Branched-chain amino acid catabolism","EGR2 and SOX10-mediated initiation of Schwann cell myelination","snRNP Assembly","Leishmania infection","Cellular response to hypoxia",
"trans-Golgi Network Vesicle Budding","SARS-CoV-1 Infection","Ethanol oxidation","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","G0 and Early G1","Glycogen storage diseases"
,"Cytochrome P450 - arranged by substrate type","Interleukin-1 family signaling","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Ann
ealing (SSA)","Mitotic Metaphase and Anaphase","Transcriptional regulation by RUNX3","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","G1/S Transition","Leishmania parasi
te growth and survival","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Golgi Associated Vesicle Biogenesis","SARS-CoV-1 Genome Replication and Transcription","Amine ligand
-binding receptors","Biosynthesis of maresins","Glycogen storage disease type II (GAA)",Xenobiotics,"Interleukin-1 signaling","Post NMDA receptor activation events","HDR through Homologous Recombinati
on (HRR)","Mitotic Anaphase","Biosynthesis of D-series resolvins","RUNX3 Regulates Immune Response and Cell Migration","PCNA-Dependent Long Patch Base Excision Repair","Activation of the pre-replicati
ve complex","Anti-inflammatory response favouring Leishmania parasite infection","Replication of the SARS-CoV-1 genome","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","CYP2E1
 reactions","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","Nuclear Envelope (NE) Reassembly","Aromatic amines can 
be N-hydroxylated or N-dealkylated by CYP1A2","ADORA2B mediated anti-inflammatory cytokines production","Presynaptic phase of homologous DNA pairing and strand exchange","Initiation of Nuclear Envelop
e (NE) Reformation"}

> <broad_targets>
{GSK3A,GSK3B,RPS6KB1}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{264218-23-7,264218237,"SB 415286",SB-415286,SB415286,"3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione","3(3chloro4hydroxyphenylamino)4(2nitrophenyl)1Hpyrrole2,5dione","3-(3-c
hloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione","3(3chloro4hydroxyphenylamino)4(4nitrophenyl)1Hpyrrole2,5dione",CHEMBL322970,3-((3-chloro-4-hydroxyphenyl)amino)-4-(,3((3chloro4hydr
oxyphenyl)amino)4(,T6659,1617,S2729}

> <pdid>
PD002735

> <targets>
{GSK-3}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{4210951}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  1  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0  2  0  0  0
   -1.4470    5.2297    0.0000 C   0  0  2  0  0  0
   -2.9153    5.5365    0.0000 C   0  0
   -3.6607    4.2349    0.0000 O   0  0
   -2.6532    3.1236    0.0000 C   0  0
   -2.9512    1.6535    0.0000 O   0  0
   -0.3273    6.2252    0.0000 C   0  0
    1.0974    5.7534    0.0000 C   0  0
    2.2199    6.7484    0.0000 C   0  0
    3.6428    6.2739    0.0000 C   0  0
    3.9434    4.8044    0.0000 C   0  0
    5.3682    4.3326    0.0000 O   0  0
    6.4892    5.3293    0.0000 C   0  0
    2.8210    3.8093    0.0000 C   0  0
    3.1188    2.3383    0.0000 O   0  0
    1.9950    1.3448    0.0000 C   0  0
    1.3981    4.2837    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  7  6  1  1
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11  7  1  0
 11 12  2  0
  8 13  1  6
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 20 23  2  0
 23 14  1  0
  5 24  2  0
 24 25  1  0
 25 26  2  0
 26  3  1  0
 26 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28276

> <plate>
Kinase v5-1

> <well>
E22

> <supplier_cmpd_name>
Arctigenin

> <ctcr_id>
7685

> <supplier_cmpd_id>
1777

> <smiles>
COc1cc(C[C@@H]2[C@H](COC2=O)Cc3ccc(OC)c(OC)c3)ccc1O

> <pd_targets>
{CYP2C9,MAP2K1,CYP2C19,RORC,CYP3A4,MAPK1,CYP1A2}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Cytochrome P450",Kinase,"Nuclear receptor","Cytochrome P450 family 2","Protein Kinase","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3","Cytochrome P45
0 family 1","Cytochrome P450 family 2C","STE protein kinase group","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 3A","CMGC protein kinase group","Cytochrome P450 family 1A","C
ytochrome P450 2C9","STE protein kinase STE7 family","Cytochrome P450 2C19","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 3A4","CMGC protein kinase MAPK family","Cytochrome 
P450 1A1","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","CYP2 family: drug metabolising subset","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","1F
. Retinoic acid-related orphans","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP1 family","STE7 family","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Signal Transduction","Gene expression (Transcription)","Immune System","Biological oxidations","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Metabolism of li
pids","Innate Immune System","Phase I - Functionalization of compounds","Signaling by NTRKs","Generic Transcription Pathway","Biosynthesis of specialized proresolving mediators (SPMs)","Toll-like Rece
ptor Cascades","Cytochrome P450 - arranged by substrate type","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX3","Biosynthesis of DHA-derived SPMs","Toll Like Receptor 5 (TLR5) Cascade"
,Xenobiotics,"Signalling to ERKs","RUNX3 Regulates Immune Response and Cell Migration","Biosynthesis of maresins","MyD88 cascade initiated on plasma membrane","CYP2E1 reactions","Prolonged ERK activat
ion events","Biosynthesis of maresin-like SPMs","MAP kinase activation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Frs2-mediated activation","MAPK targets/ Nuclear events medi
ated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{CHUK,MAP2K1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{Arctigenin,(-)-Arctigenin,()Arctigenin,7770-78-7,7770787,UNII-U76MR9VS6M,UNIIU76MR9VS6M,C21H24O6,CHEBI:79,U76MR9VS6M,(+/-)-Arctigenin,(+/)Arctigenin,"Arctigenin, (+/-)-","Arctigenin, (+/)",Arctigenen
,"Arctigenin, trans-((+/-)-","Arctigenin, trans((+/)",Tocris-1777,Tocris1777,SCHEMBL381820,CHEMBL435734,MEGxp0_001799,MEGxp0001799,MEGxp0-001799,"MEGxp0 001799",ACon1_000416,ACon1000416,ACon1-000416,"
ACon1 000416",DTXSID60998919,HMS32,1777}

> <pdid>
PD012062

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{64981}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 16  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 12 13  1  0
 13 14  2  0
 14  2  1  0
 14  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28277

> <plate>
Kinase v5-1

> <well>
G04

> <supplier_cmpd_name>
NSC 693868

> <ctcr_id>
6310

> <supplier_cmpd_id>
1937

> <smiles>
Nc1n[nH]c2nc3ccccc3nc12

> <pd_targets>
{GSK3B,CYP2C9,MAPT,RORC,KMT2A,MEN1,LEF,EIF2AK2,CYP2C19,CCNA2,CDK2,CDK1,CYP3A4,CYP1A2,CDK5,CDK5R1,IMPA1,TP53,CCNT1,CDK9,CCNE1,CCNB1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Transcription factor","Epigenetic regulator",Kinase,"Cytochrome P450","Nuclear receptor",Reader,Protease,Hydrolase,"Protein Kinase","Cytochrome P450 family 2","Nucle
ar hormone receptor subfamily 1",Bromodomain,"Metallo protease","Cytochrome P450 family 3","Cytochrome P450 family 1","CMGC protein kinase group","Cytochrome P450 family 2C","Nuclear hormone receptor 
subfamily 1 group F","Metallo protease MAE clan","Other protein kinase group","Cytochrome P450 family 3A","Cytochrome P450 family 1A","CMGC protein kinase GSK family","Cytochrome P450 2C9","Nuclear ho
rmone receptor subfamily 1 group F member 3","Metallo protease M34 family","Other protein kinase PEK family","Cytochrome P450 2C19","CMGC protein kinase CDK family","Cytochrome P450 3A4","Cytochrome P
450 1A1","Other protein kinase PKR","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Cytochrome P450","Nuclear hormone receptors","Catalytic receptors","Inositol phosphate turnover","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP2 family
: drug metabolising subset","1F. Retinoic acid-related orphans","Receptor kinases","CYP3 family","CYP1 family","Inositol monophosphatase","Glycogen synthase kinase (GSK) family","Other protein kinases
","Cyclin-dependent kinase (CDK) family","GSK subfamily","PEK family","CDK1 subfamily","CDK5 subfamily","Other PEK family kinases"}

> <pathway_reactome>
{Disease,Metabolism,"Neuronal System","Gene expression (Transcription)","Cell Cycle","Infectious disease","Biological oxidations","Transmission across Chemical Synapses","RNA Polymerase II Transcripti
on",Mitotic,"Metabolism of lipids","Inositol phosphate metabolism","Cell Cycle Checkpoints","SARS-CoV Infections","Phase I - Functionalization of compounds","Neurotransmitter receptors and postsynapti
c signal transmission","Generic Transcription Pathway","Uptake and actions of bacterial toxins","Influenza Infection","Regulation of mitotic cell cycle","Biosynthesis of specialized proresolving media
tors (SPMs)","Synthesis of IP2",IP,"and Ins in the cytosol","G1/S DNA Damage Checkpoints","SARS-CoV-1 Infection","Cytochrome P450 - arranged by substrate type","Activation of NMDA receptors and postsy
naptic events","Transcriptional regulation by RUNX3","Uptake and function of anthrax toxins","NS1 Mediated Effects on Host Pathways","APC/C-mediated degradation of cell cycle proteins","Biosynthesis o
f DHA-derived SPMs","p53-Dependent G1/S DNA damage checkpoint","Transcriptional Regulation by TP53","SARS-CoV-1 Genome Replication and Transcription",Xenobiotics,"Post NMDA receptor activation events"
,"RUNX3 Regulates Immune Response and Cell Migration","Inhibition of PKR","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Biosynthesis of maresins","p53-Dependent G1 DN
A Damage Response","Regulation of TP53 Activity","Replication of the SARS-CoV-1 genome","CYP2E1 reactions","Activation of AMPK downstream of NMDARs","APC/C:Cdc20 mediated degradation of mitotic protei
ns","Biosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Stabilization of p53","Regulation of TP53 Activity through Phosphorylation","APC:Cdc20 media
ted degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Autodegradation of the E3 ubiquitin ligase COP1","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{40254-90-8,40254908,"Cdk1/5 Inhibitor","1H-Pyrazolo(3,4-b)quinoxalin-3-amine","1HPyrazolo(3,4b)quinoxalin3amine","3-Amino-1H-pyrazolo(3,4-b)quinoxaline","3Amino1Hpyrazolo(3,4b)quinoxaline",Quinoxalin
e1,"2H-pyrazolo(4,3-b)quinoxalin-3-amine","2Hpyrazolo(4,3b)quinoxalin3amine","NSC 693868","2H-PYRAZOLO(3,4-B)QUINOXALIN-3-AMINE","2HPYRAZOLO(3,4B)QUINOXALIN3AMINE",NSC693868,56984-56-6,56984566,quinox
a,"EMD 217720",1937,217720}

> <pdid>
PD017396

> <targets>
{cdk}

> <classes>
{}

> <pubchem_cids>
{438981}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.9511   -0.8815    0.0000 N   0  0
   -4.9530   -1.9978    0.0000 C   0  0
   -4.2010   -3.2957    0.0000 N   0  0
   -2.7343   -2.9815    0.0000 C   0  0
   -1.6115   -3.9772    0.0000 C   0  0
   -0.1605   -3.6178    0.0000 C   0  0
    0.8791   -4.6991    0.0000 C   0  0
    0.4626   -6.1401    0.0000 C   0  0
    1.5022   -7.2213    0.0000 F   0  0
   -0.9936   -6.4998    0.0000 C   0  0
   -2.0333   -5.4186    0.0000 C   0  0
   -4.2568    0.5878    0.0000 C   0  0
   -3.2235    1.6679    0.0000 C   0  0
   -3.6446    3.1076    0.0000 C   0  0
   -5.1020    3.4627    0.0000 C   0  0
   -5.5231    4.9024    0.0000 O   0  0
   -6.1382    2.3782    0.0000 C   0  0
   -5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  9  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 14  1  0
 10 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 26 27  1  0
 27 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28278

> <plate>
Kinase v5-1

> <well>
G06

> <supplier_cmpd_name>
SB 239063

> <ctcr_id>
4949

> <supplier_cmpd_id>
1962

> <smiles>
COc1nccc(n1)c2n(cnc2c3ccc(F)cc3)C4CCC(O)CC4

> <pd_targets>
{MAPK14,LCK,MAPK11,PRKCA,MAPK9,EGFR,RAF1,CYP2D6,CYP2C9,CSNK1D,MINK1,KDM4E,MAP4K4,PRKD2,CSNK1A1,CYP2C19,CYP1A2,PRKD3,MAP4K5,RORC,FRK}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Transcription factor",Kinase,"Cytochrome P450",Eraser,"Nuclear receptor","Protein Kinase","Cytochrome P450 family 2","Lysine demethylase","Cytochrome P450 family 1","Nu
clear hormone receptor subfamily 1","CMGC protein kinase group","TK protein kinase group","AGC protein kinase group","TKL protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 2C",
"CK1 protein kinase group","STE protein kinase group","Jumonji domain-containing","CAMK protein kinase group","Cytochrome P450 family 1A","Nuclear hormone receptor subfamily 1 group F","CMGC protein k
inase MAPK family","Tyrosine protein kinase Src family","AGC protein kinase PKC family","Tyrosine protein kinase EGFR family","TKL protein kinase RAF family","Cytochrome P450 2D6","Cytochrome P450 2C9
","CK1 protein kinase CK1 family","STE protein kinase STE20 family","CAMK protein kinase PKD family","Cytochrome P450 2C19","Cytochrome P450 1A1","Nuclear hormone receptor subfamily 1 group F member 3
","CMGC protein kinase p38 subfamily","AGC protein kinase PKC alpha subfamily","CMGC protein kinase JNK subfamily","STE protein kinase MSN subfamily","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Cytochrome P450","Chromatin modifying enzymes","Nuclear hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor ki
nases","AGC: Containing PKA",PKG,"PKC families","CYP2 family: drug metabolising subset","CK1: Casein kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","1.14.11.- Histone d
emethylases","CAMK: Calcium/calmodulin-dependent protein kinases","CYP1 family","1F. Retinoic acid-related orphans","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","Protein kin
ase C (PKC) family","TKL: Tyrosine kinase-like","Casein kinase 1 (CK1) family","STE20 family","Protein kinase D (PKD) family","p38 subfamily","Non-receptor tyrosine kinases (nRTKs)","Delta subfamily",
"JNK subfamily","Receptor tyrosine kinases (RTKs)","RAF family","MSN subfamily","KHS subfamily","Src family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Immune System",Disease,"Signal Transduction",Metabolism,"Cell Cycle","Cellular responses to external stimuli","Gene expression (Transcription)","Innate Immune System","Infectious disease","Signaling
 by GPCR","MAPK family signaling cascades","Biological oxidations",Mitotic,"Cellular responses to stress","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second 
messengers","RNA Polymerase II Transcription","Intracellular signaling by second messengers","Toll-like Receptor Cascades","HIV Infection","GPCR downstream signalling","MAPK1/MAPK3 signaling","Phase I
 - Functionalization of compounds","Mitotic G2-G2/M phases","Cellular Senescence","Sphingolipid metabolism","Signaling by WNT in cancer","Generic Transcription Pathway","PIP3 activates AKT signaling",
"Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","G alpha (i) signalling events","G alpha (q) signalling events","RAF/MAP kinase cascade","Cytochrome P450 - arranged by substra
te type","G2/M Transition","Oxidative Stress Induced Senescence","Sphingolipid de novo biosynthesis","Signaling by AMER1 mutants","Transcriptional regulation by RUNX3","PTEN Regulation","MyD88 cascade
 initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Visual phototransduction","Gastrin-CREB signalling pathway via PKC and MAPK","Negative regulation of MAP
K pathway",Xenobiotics,"Centrosome maturation","Truncations of AMER1 destabilize the destruction complex","RUNX3 Regulates Immune Response and Cell Migration","Regulation of PTEN stability and activit
y","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","The phototransduction cascade","EGFR Transactivation by Gastrin","Negative 
feedback regulation of MAPK pathway","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","Aromatic amines can be N-hydroxylated or N-dealkylated 
by CYP1A2","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation",Inactivation,"recovery and regulation of the phototransduction cascade","Loss of Nlp from mitotic c
entrosomes","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK11,MAPK14,PTGS2}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"SB 239063",193551-21-2,193551212,SB239063,SB-239063,UNII-HII3DC8CPI,UNIIHII3DC8CPI,CHEMBL97162,HII3DC8CPI,CHEMBL4166018,CHEBI:90681,MFCD03792786,Kinome_3168,Kinome3168,Kinome-3168,"Kinome 3168",Tocr
is-1962,Tocris1962,cc-465,cc465,MLS006010690,SCHEMBL173595,SCHEMBL173596,CHEMBL256835,SCHEMBL4918359,SCHEMBL13933075,CHEBI:91347,"EMD 559404",1962,559404}

> <pdid>
PD013030

> <targets>
{"p38 MAPK","SB 239063"}

> <classes>
{}

> <pubchem_cids>
{5166}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 24  0  0  0  0            999 V2000
    1.2948   -3.7516    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1944   -3.0088    0.0000 C   0  0
    6.4947   -2.2611    0.0000 N   0  0
    3.8912   -5.2578    0.0000 C   0  0
    2.5895   -6.0034    0.0000 C   0  0
    2.5844   -7.5034    0.0000 C   0  0
    3.8808   -8.2579    0.0000 C   0  0
    5.1824   -7.5124    0.0000 C   0  0
    5.1876   -6.0124    0.0000 C   0  0
    6.4900   -5.2665    0.0000 C   0  0
    7.7869   -6.0202    0.0000 F   0  0
    6.4947   -3.7665    0.0000 F   0  0
    7.7913   -4.5204    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  7  9  1  0
  9 10  2  0
 10  4  1  0
  2 11  2  0
 11 12  1  0
 12 13  3  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 20 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28279

> <plate>
Kinase v5-1

> <well>
G08

> <supplier_cmpd_name>
SL 327

> <ctcr_id>
7690

> <supplier_cmpd_id>
1969

> <smiles>
N\C(Sc1ccc(N)cc1)=C(C#N)/c2ccccc2C(F)(F)F

> <pd_targets>
{MAP2K2,RORC,HSD17B10,JUN,MAPK1,CYP3A4,MAPT,ALOX15,FTL,ALDH1A1,KMT2A,MEN1}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Other cytosolic protein","Unclassified protein","Epigenetic regulator",Kinase,"Nuclear receptor",Oxidoreductase,"Cytochrome P450",Reader,"Protein Kinase","Nuclear hormo
ne receptor subfamily 1","Cytochrome P450 family 3",Bromodomain,"STE protein kinase group","Nuclear hormone receptor subfamily 1 group F","CMGC protein kinase group","Cytochrome P450 family 3A","STE p
rotein kinase STE7 family","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase MAPK family","Cytochrome P450 3A4","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Cytochrome P450","Eicosanoid turnover","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","1F. Retinoic acid-re
lated orphans","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP3 family",Lipoxygenases,"STE7 family","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Metabolism,"Immune System","Neuronal System","Vesicle-mediated transport","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcrip
tion","Metabolism of amino acids and derivatives","Innate Immune System","Metabolism of lipids","Transmission across Chemical Synapses","Membrane Trafficking","Biological oxidations","Signaling by NTR
Ks","Generic Transcription Pathway","Branched-chain amino acid catabolism","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotransmitter receptors and pos
tsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Phase I - Functionalization of compounds","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX3","Toll Like Receptor 5 
(TLR5) Cascade","Biosynthesis of DHA-derived SPMs","Activation of NMDA receptors and postsynaptic events","Biosynthesis of DPA-derived SPMs","Golgi Associated Vesicle Biogenesis","Ethanol oxidation","
Signalling to ERKs","RUNX3 Regulates Immune Response and Cell Migration","MyD88 cascade initiated on plasma membrane","Biosynthesis of maresins","Post NMDA receptor activation events","Biosynthesis of
 DPAn-3 SPMs","Prolonged ERK activation events","MAP kinase activation","Biosynthesis of maresin-like SPMs","Activation of AMPK downstream of NMDARs","Biosynthesis of DPAn-3-derived protectins and res
olvins","Frs2-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SL327,305350-87-2,305350872,"305350 87 2",SL-327,"SL 327","MEK1/2 Inhibitor",C16H12F3N3S,MFCD06411432,K00090,SCHEMBL570317,SCHEMBL570318,GTPL6008,CHEBI:92211,AOB5954,DTXSID90429549,HMS3229K18,HMS3414
M21,HMS3678M21,HMS3884G03,BCP05310,EX-A1069,EXA1069,EXA106,"EMD 444939",1969,444939}

> <pdid>
PD011155

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{9549284}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 41  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.2559   -4.6520    0.0000 C   0  0
    5.8646   -6.1001    0.0000 N   0  0
    6.8071   -7.2647    0.0000 C   0  0
    8.2897   -7.0313    0.0000 C   0  0
    9.2338   -8.1979    0.0000 C   0  0
   10.7164   -7.9645    0.0000 S   0  0
   11.6605   -9.1312    0.0000 C   0  0
   11.1221  -10.5312    0.0000 N   0  0
   13.1423   -8.8979    0.0000 N   0  0
    4.3672   -6.1750    0.0000 C   0  0
    3.4207   -7.3387    0.0000 C   0  0
    1.9397   -7.1008    0.0000 C   0  0
    1.4052   -5.6993    0.0000 C   0  0
    2.3517   -4.5356    0.0000 C   0  0
    3.8327   -4.7735    0.0000 C   0  0
   16.9431   -3.0160    0.0000 C   0  0
   16.9431   -4.5160    0.0000 S   0  0
   16.9431   -6.0160    0.0000 O   0  0
   15.6438   -5.2655    0.0000 O   0  0
   18.2424   -5.2655    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10  5  1  0
  4 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 12 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 25 27  2  0
 20 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 18  1  0
 33 28  1  0
 34 35  1  0
 35 36  1  0
 35 37  2  0
 35 38  2  0
M  END
> <name>
UTKinase_V5

> <id>
28280

> <plate>
Kinase v5-1

> <well>
G10

> <supplier_cmpd_name>
Ro 31-8220 mesylate

> <ctcr_id>
2798

> <supplier_cmpd_id>
2002

> <smiles>
Cn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4cn(CCCSC(N)=N)c5ccccc45.C[S](O)(=O)=O

> <pd_targets>
{PRKCA,HST2,HIPK1,TP53,SIRT1,SIRT2,RPS6KB1,PIM1,PRKCB,TBK1,RPS6KA3,GSK3B,MAPT,FTL,RPS6KA2,KMT2A,MEN1,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,MDH,SIRT3,RORC,ALD,PRKACA,CTRB1,FFP,MAP4K1,VR
K2,MAP3K8,VRK1,MAPK1,RECQL,HSD17B10,CYP3A4,TSHR,ALOX15,LEF,RPS6KA5}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator","Other cytosolic protein","Unclassified protein","Membrane receptor",Kinase,Eraser,Reader,Oxidoreductase,"Nuclear receptor",Transferase,Protease,"
Cytochrome P450","Family A G protein-coupled receptor","Protein Kinase","Histone deacetylase",Bromodomain,"Nuclear hormone receptor subfamily 1","Serine protease","Cysteine protease","Cytochrome P450 
family 3","Peptide receptor (family A GPCR)","Metallo protease","AGC protein kinase group","CMGC protein kinase group","HDAC class III","CAMK protein kinase group","Other protein kinase group","Nuclea
r hormone receptor subfamily 1 group F","STE protein kinase group","CK1 protein kinase group","Serine protease PA clan","Cysteine protease CA clan","Cytochrome P450 family 3A","Glycohormone receptor",
"Metallo protease MAE clan","AGC protein kinase PKC family","CMGC protein kinase DYRK family","AGC protein kinase RSK family","CAMK protein kinase PIM family","Other protein kinase IKK family","CMGC p
rotein kinase GSK family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKA family","STE protein kinase STE20 family","STE protein kinase STE11 family","CK1 protein kinas
e VRK family","Serine protease S1A subfamily","CMGC protein kinase MAPK family","Cysteine protease C1A family","Cytochrome P450 3A4","Metallo protease M34 family","AGC protein kinase PKC alpha subfami
ly","CMGC protein kinase HIPK subfamily","AGC protein kinase p70 subfamily","AGC protein kinase RSK subfamily","STE protein kinase KHS subfamily","CMGC protein kinase ERK1","AGC protein kinase MSK sub
family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Catalytic receptors","Nuclear hormone receptors","Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","AGC: Co
ntaining PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","3.5.1.- Histone deacetylases (HDACs)","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","1F. Ret
inoic acid-related orphans","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","CYP3 family","Glycoprotein hormone receptors",Lipoxygenases,"Protein kinase C (
PKC) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","RSK family","PIM family","Other protein kinases","Glycogen synthase kinase (GSK) family","Protein kinase A 
(PKA) family","STE20 family","Vaccina related kinase (VRK) family","STE-unique family","Mitogen-activated protein kinases (MAP kinases)","Delta subfamily","HIPK subfamily","p70 subfamily","Alpha subfa
mily","IKK family","RSK subfamily","GSK subfamily","KHS subfamily","ERK subfamily","MSK subfamily"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Cell Cycle",Disease,"Immune System","Neuronal System","Vesicle-mediated transport",Metabolism,"Signaling by GPCR","RNA Polymerase II Transcrip
tion","Cell Cycle Checkpoints",Mitotic,"MTOR signalling","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System","Infectious disease","Transmission ac
ross Chemical Synapses","Membrane Trafficking","Cytokine Signaling in Immune system","Metabolism of vitamins and cofactors","Metabolism of amino acids and derivatives","Metabolism of lipids","GPCR dow
nstream signalling","Generic Transcription Pathway","G1/S DNA Damage Checkpoints","M Phase","mTORC1-mediated signalling","FLT3 signaling in disease","Toll-like Receptor Cascades","SARS-CoV Infections"
,"Neurotransmitter receptors and postsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","Signaling by Interleukins","Metabolism of water-soluble vitamins and 
cofactors","Branched-chain amino acid catabolism","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","Uptake and actions of bacterial toxins","G alpha (i) signalling ev
ents","Transcriptional Regulation by TP53","p53-Dependent G1/S DNA damage checkpoint","FOXO-mediated transcription","Mitotic Metaphase and Anaphase","Signaling by FLT3 ITD and TKD mutants","Mitotic Pr
ophase","Toll Like Receptor 4 (TLR4) Cascade","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-1 Infection","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis",
"Transcriptional regulation by RUNX3","G2/M Transition","Interleukin-1 family signaling","Cobalamin (Cbl","vitamin B12) transport and metabolism","Biosynthesis of DHA-derived SPMs","Leishmania parasit
e growth and survival","Biosynthesis of DPA-derived SPMs","Uptake and function of anthrax toxins","Visual phototransduction","Regulation of TP53 Activity","p53-Dependent G1 DNA Damage Response","Regul
ation of FOXO transcriptional activity by acetylation","Mitotic Anaphase","STAT5 activation downstream of FLT3 ITD mutants","Nuclear Envelope Breakdown","MyD88-independent TLR4 cascade","MyD88 cascade
 initiated on plasma membrane","SARS-CoV-1 Genome Replication and Transcription","Post NMDA receptor activation events","FOXO-mediated transcription of oxidative stress","metabolic and neuronal genes"
,"RUNX3 Regulates Immune Response and Cell Migration","Centrosome maturation","Interleukin-1 signaling","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection",
"Biosynthesis of DPAn-3 SPMs","The phototransduction cascade","Regulation of TP53 Activity through Phosphorylation","Stabilization of p53","Nuclear Envelope (NE) Reassembly","Depolymerisation of the N
uclear Lamina","TRIF(TICAM1)-mediated TLR4 signaling","MAP kinase activation","Replication of the SARS-CoV-1 genome","Activation of AMPK downstream of NMDARs","Loss of proteins required for interphase
 microtubule organization from the centrosome","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammatory cytokines production","Biosynthesis 
of DPAn-3-derived protectins and resolvins",Inactivation,"recovery and regulation of the phototransduction cascade","Autodegradation of the E3 ubiquitin ligase COP1","Initiation of Nuclear Envelope (N
E) Reformation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","MAPK targets/ Nuclear events mediated by MAP kinases","Loss of Nlp from mitotic centrosomes","CREB phosphorylation","ERK/MAPK ta
rgets","ERKs are inactivated"}

> <broad_targets>
{AKT1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,ROCK1,RPS6KB1,SIRT1}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{"Ro 31-8220 mesylate","Ro 318220 mesylate",138489-18-6,138489186,"Bisindolylmaleimide IX mesylate","Ro 31-8220 (mesylate)","Ro 318220 (mesylate)","RO31-8220 mesylate","RO318220 mesylate","Bisindolylm
aleimide IX, Methanesulfonate",CHEMBL1591531,"InSolution&trade; Ro-31-8220","InSolution&trade; Ro318220",BMK1-D9,BMK1D9,"RO31-8220 methanesulfonate","RO318220 methanesulfonate",Ro?31-8220,Ro?318220,T6
643,"EMD 557520",2002,EI-283,"Ro 31-8220 Mesylate",557520}

> <pdid>
PD038906

> <targets>
{"Broad Spectrum Inhibitor",Ro-31-8220,PKC}

> <classes>
{}

> <pubchem_cids>
{11628205}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    1.2873   -5.2494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    2.6160    7.4949    0.0000 N   0  0
    3.9072    5.2405    0.0000 C   0  0
    3.9020    3.7405    0.0000 C   0  0
    5.1985    2.9860    0.0000 Cl  0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 14 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 19 12  1  0
 10 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 23 27  1  0
 27 20  1  0
 27 28  2  0
 28  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28281

> <plate>
Kinase v5-1

> <well>
G12

> <supplier_cmpd_name>
Aminopurvalanol A

> <ctcr_id>
1611

> <supplier_cmpd_id>
2072

> <smiles>
CC(C)C(CO)Nc1nc(Nc2cc(N)cc(Cl)c2)c3ncn(C(C)C)c3n1

> <pd_targets>
{ALDH1A1,CDK5,MAPT,CYP3A4,CDK1,TSHR,CYP2C9,MAPK1,HPGD,CDK2,RORC,KDM4E,LEF,KMT2A,MEN1,CYP1A2,CCNB1,CCNB2,CCNB3,CLK1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Membrane receptor","Transcription factor","Epigenetic regulator",Oxidoreductase,Kinase,"Cytochrome P450","Family A G protein-coupled receptor","Nuclear receptor",Era
ser,Protease,Reader,"Protein Kinase","Cytochrome P450 family 3","Peptide receptor (family A GPCR)","Cytochrome P450 family 2","Nuclear hormone receptor subfamily 1","Lysine demethylase","Metallo prote
ase",Bromodomain,"Cytochrome P450 family 1","CMGC protein kinase group","Cytochrome P450 family 3A","Glycohormone receptor","Cytochrome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","
Jumonji domain-containing","Metallo protease MAE clan","Cytochrome P450 family 1A","CMGC protein kinase CDK family","Cytochrome P450 3A4","Cytochrome P450 2C9","CMGC protein kinase MAPK family","Nucle
ar hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Cytochrome P450 1A1","CMGC protein kinase CLK family","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDC2 su
bfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","Nuclear hormone receptors","Chromatin modifying enzymes","CMGC: Containing CDK",MAPK,GS
K3,"CLK families","CYP3 family","Glycoprotein hormone receptors","CYP2 family: drug metabolising subset","Prostaglandin synthases","1F. Retinoic acid-related orphans","1.14.11.- Histone demethylases",
"CYP1 family","Cyclin-dependent kinase (CDK) family","Mitogen-activated protein kinases (MAP kinases)","CLK family","CDK5 subfamily","CDK1 subfamily","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Gene expression (Transcription)","Neuronal System","Cell Cycle",Disease,"Immune System","Biological oxidations","RNA Polymerase II Transcription","Transmission across Chemical Synapses","
Metabolism of lipids",Mitotic,"Infectious disease","Innate Immune System","Phase I - Functionalization of compounds","Generic Transcription Pathway","Neurotransmitter receptors and postsynaptic signal
 transmission","Biosynthesis of specialized proresolving mediators (SPMs)","Regulation of mitotic cell cycle","Leishmania infection","Toll-like Receptor Cascades","Uptake and actions of bacterial toxi
ns","Ethanol oxidation","Transcriptional Regulation by TP53","Activation of NMDA receptors and postsynaptic events","Biosynthesis of DHA-derived SPMs","APC/C-mediated degradation of cell cycle protein
s","Leishmania parasite growth and survival","Cytochrome P450 - arranged by substrate type","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional regulation by RUNX3","Uptake and function of anthrax 
toxins","Regulation of TP53 Activity","Post NMDA receptor activation events","Biosynthesis of maresins","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Anti-inflammator
y response favouring Leishmania parasite infection",Xenobiotics,"MyD88 cascade initiated on plasma membrane","Biosynthesis of D-series resolvins","RUNX3 Regulates Immune Response and Cell Migration","
Regulation of TP53 Activity through Phosphorylation","Activation of AMPK downstream of NMDARs","Biosynthesis of maresin-like SPMs","APC/C:Cdc20 mediated degradation of mitotic proteins","ADORA2B media
ted anti-inflammatory cytokines production","CYP2E1 reactions","MAP kinase activation","Regulation of TP53 Expression and Degradation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Cdc
20:Phospho-APC/C mediated degradation of Cyclin A","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{CDK1,CDK2,CDK5}

> <broad_moa>
{"CDK inhibitor","tyrosine kinase inhibitor"}

> <synonyms>
{"NG 97",SCHEMBL21168739,K00613a,ZINC00582597,NCGC00390411-01,NCGC0039041101,J-014473,J014473,"EMD 164640",2072,164640,"Aminopurvalanol A"}

> <pdid>
PD005842

> <targets>
{"Cyclin-dependent Kinase",cdk}

> <classes>
{}

> <pubchem_cids>
{9549304}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -5.1072    0.0000    0.0000 C   0  0
   -5.8659   -1.2803    0.0000 O   0  0
   -7.3243   -0.9298    0.0000 C   0  0
   -8.4618   -1.9049    0.0000 C   0  0
   -8.1867   -3.3795    0.0000 O   0  0
   -7.4417    0.5656    0.0000 C   0  0
   -8.7205    1.3496    0.0000 O   0  0
   -6.0557    1.1393    0.0000 C   0  0
   -5.6962    2.5956    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -2.8161   -2.7592    0.0000 N   0  0
   -1.6025   -3.6408    0.0000 C   0  0
   -0.2322   -3.0307    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  4  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 11 14  1  0
 14 15  1  0
 14 16  1  0
 16  9  1  0
 16 17  1  0
  8 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22  2  1  0
 22 23  2  0
 23  6  1  0
 23 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28282

> <plate>
Kinase v5-1

> <well>
G14

> <supplier_cmpd_name>
API-2

> <ctcr_id>
1508

> <supplier_cmpd_id>
2151

> <smiles>
CN1N=C(N)c2cn(C3OC(CO)C(O)C3O)c4ncnc1c24

> <pd_targets>
{POL}

> <pathway_gtopdb>
{Enzyme,Hydrolase}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
{AKT1,AKT2,AKT3}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{NSC154020,MLS002702033,"API-2;NSC 154020;TCN","API2;NSC 154020;TCN","Akt/PKB Signaling Inhibitor-2","Akt/PKB Signaling Inhibitor2",NSC-154020,TCN,"Akt Inhibitor V, Triciribine","Akt inhibitor V","tri
cyclic nucleoside (TCN)",SCHEMBL61269,GTPL5920,CHEMBL1892348,CHEBI:91697,HMS3229A09,HMS3268N05,HMS3,T6065,"EMD 124012",EI-332,2151,"NSC 154020",Triciribine,124012,API-2}

> <pdid>
PD011889

> <targets>
{PKB,"Akt signaling pathway",Akt,"DNA/RNA Synthesis",HIV}

> <classes>
{Anti-infection,Cell Cycle/DNA Damage,PI3K/Akt/mTOR}

> <pubchem_cids>
{290486}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    3.8794   -1.4442    0.0000 C   0  0
    4.8823   -2.5608    0.0000 C   0  0
    4.5513   -4.0107    0.0000 C   0  0
    3.1755   -4.6084    0.0000 O   0  0
    5.8480   -4.7648    0.0000 N   0  0
    6.9651   -3.7649    0.0000 C   0  0
    8.4564   -3.9264    0.0000 C   0  0
    9.3418   -2.7156    0.0000 C   0  0
    8.7360   -1.3434    0.0000 C   0  0
    7.2447   -1.1820    0.0000 N   0  0
    6.3593   -2.3927    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21  2  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28283

> <plate>
Kinase v5-1

> <well>
G16

> <supplier_cmpd_name>
GW 441756

> <ctcr_id>
7732

> <supplier_cmpd_id>
2238

> <smiles>
Cn1cc(\C=C2/C(=O)Nc3cccnc23)c4ccccc14

> <pd_targets>
{FLT4,STK17A,MAP3K20,IRAK1,NEK4,CLK4,CSNK1A1,MAPK9,AURKA,MINK1,NTRK1,IRAK4,CAMK2G,FFP,CHEK2,IGF1R,RET,KMT2A,MEN1,PRKD2,SGK2,MARK2,ALK,LCK,CDK5,CLK2,MAP4K4,PHKG2,PIM1,PIM3,DYRK1A,MAP4K2,CSNK1D,NTRK2,NT
RK3,PKN2,MAP4K5,MAPT,RPS6KA3,BRSK1,INSR,LYN,SYK,ROCK1,PRKAA1,ITK,KDR,CDK1,AURKB,HIPK2,HIPK4,NEK2,STK3,PRKD3,ROCK2,MARK3,FER,FRK,SRC,GSK3B,SLK,BLK,FGFR1,CDK2,CSNK2A1,RPS6KB1,CAMK2D}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein",Kinase,Transferase,Reader,"Protein Kinase",Bromodomain,"TK protein kinase group","CAMK protein kinase group","TKL protein kinase group","Other 
protein kinase group","CMGC protein kinase group","CK1 protein kinase group","STE protein kinase group","AGC protein kinase group","Tyrosine protein kinase VEGFR family","CAMK protein kinase DAPK fami
ly","TKL protein kinase MLK family","TKL protein kinase IRAK family","Other protein kinase NEK family","CMGC protein kinase CLK family","CK1 protein kinase CK1 family","CMGC protein kinase MAPK family
","Other protein kinase AUR family","STE protein kinase STE20 family","Tyrosine protein kinase Trk family","CAMK protein kinase CAMK2 family","CAMK protein kinase RAD53 family","Tyrosine protein kinas
e InsR family","Tyrosine protein kinase Ret family","CAMK protein kinase PKD family","AGC protein kinase SGK family","CAMK protein kinase CAMK1 family","TKL protein kinase STKR family","Tyrosine prote
in kinase Src family","CMGC protein kinase CDK family","CAMK protein kinase PHk family","CAMK protein kinase PIM family","CMGC protein kinase DYRK family","AGC protein kinase PKN family","AGC protein 
kinase RSK family","Tyrosine protein kinase Syk family","AGC protein kinase DMPK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Fer family","CMGC protein kinase GSK family","Tyr
osine protein kinase FGFR family","Other protein kinase CK2 family","TKL protein kinase MLK subfamily","CMGC protein kinase JNK subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MARK 
subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase Dyrk1 subfamily","STE protein kinase KHS subfamily","AGC protein kinase RSK subfamily","
CAMK protein kinase BRSK subfamily","AGC protein kinase ROCK subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase HIPK subfamily","STE protein kina
se MST subfamily","STE protein kinase SLK subfamily","AGC protein kinase p70 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kin
ase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","TK: Tyrosine kinase","Death-associated kinase (DAPK) family","TKL: Tyrosine kinase
-like","Other protein kinases","CLK family","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","STE20 family","CAMK2 family","CAMK-like (CAMKL) family","Protein kinase D 
(PKD) family","SGK family","Cyclin-dependent kinase (CDK) family","Phosphorylase kinase (PHK) family","PIM family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Prote
in kinase N (PKN) family","RSK family","DMPK family","Glycogen synthase kinase (GSK) family","Receptor tyrosine kinases (RTKs)","Mixed Lineage Kinase (MLK) family","Interleukin-1 receptor-associated k
inase (IRAK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","JNK subfamily","Aurora kinase (Aur) family","MSN subfamily","CHK1 subfamily","MARK subfamily","Non-receptor tyrosine
 kinases (nRTKs)","CDK5 subfamily","Dyrk1 subfamily","KHS subfamily","RSK subfamily","BRSK subfamily","Rho kinase","AMPK subfamily","CDK1 subfamily","HIPK subfamily","MST subfamily","GSK subfamily","S
LK subfamily","Casein kinase 2 (CK2) family","p70 subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","MLK subfamily","Type VII RTKs: Neurotrophin receptor/Trk family"
,"Type II RTKs: Insulin receptor family","Type XIV RTKs: RET","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Src family","Syk family","Tec family","Fer family","Type V RTKs: FGF (fi
broblast growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Disease,"Gene expression (Transcription)","Cellular responses to external stimuli","Neuronal System","Developmental Biology",Metabolism,"Transport of small molec
ules","Cell Cycle","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription",
"Cellular responses to stress","Transmission across Chemical Synapses","Nervous system development","Metabolism of lipids","Ion channel transport","Infectious disease","Metabolism of carbohydrates",Mi
totic,"Signaling by Rho GTPases","Intracellular signaling by second messengers","Adaptive Immune System","Signaling by Hippo","MTOR signalling","Signaling by VEGF","Toll-like Receptor Cascades","Signa
ling by WNT in cancer","Generic Transcription Pathway","Cellular Senescence","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by Type 1 Insulin-like Gr
owth Factor 1 Receptor (IGF1R)","Axon guidance","Sphingolipid metabolism","Stimuli-sensing channels","HIV Infection","Glycogen metabolism","FLT3 signaling in disease","Mitotic G1 phase and G1/S transi
tion","Mitotic G2-G2/M phases","RHO GTPase Effectors","PIP3 activates AKT signaling","Leishmania infection","TCR signaling","Regulation of mitotic cell cycle","M Phase","Oncogenic MAPK signaling","Sig
naling by SCF-KIT","SARS-CoV Infections","Signaling by FGFR in disease","mTORC1-mediated signalling","VEGF ligand-receptor interactions","Toll Like Receptor 5 (TLR5) Cascade","Signaling by AMER1 mutan
ts","Transcriptional Regulation by TP53","Oxidative Stress Induced Senescence","Signaling by NTRK1 (TRKA)","Toll Like Receptor 2 (TLR2) Cascade","Activation of NMDA receptors and postsynaptic events",
"IGF1R signaling cascade","RET signaling","Sphingolipid de novo biosynthesis","Host Interactions of HIV factors","Glycogen breakdown (glycogenolysis)","Signaling by FLT3 ITD and TKD mutants","G0 and E
arly G1","G2/M Transition","Signaling by NTRK3 (TRKC)","RHO GTPases activate PKNs","Negative regulation of the PI3K/AKT network","Leishmania parasite growth and survival","Semaphorin interactions","Ge
neration of second messenger molecules","VEGFA-VEGFR2 Pathway","APC/C-mediated degradation of cell cycle proteins","Mitotic Metaphase and Anaphase","Signaling by RAS mutants","PTEN Regulation","SARS-C
oV-1 Infection","Transcriptional regulation by RUNX1","Signaling by FGFR1 in disease","VEGF binds to VEGFR leading to receptor dimerization","MyD88 cascade initiated on plasma membrane","Truncations o
f AMER1 destabilize the destruction complex","Regulation of TP53 Activity","Signalling to ERKs","Toll Like Receptor TLR6:TLR2 Cascade","Post NMDA receptor activation events","IRS-related events trigge
red by IGF1R","The role of Nef in HIV-1 replication and disease pathogenesis","STAT5 activation downstream of FLT3 ITD mutants","Centrosome maturation","Activation of TRKA receptors","Activated NTRK3 
signals through PI3K",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Anti-inflammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","VEGFR2 mediated cell proli
feration","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Mitotic Anaphase","Signaling downstream of RAS mutants","Regulation of PTEN stability and activity","SARS-CoV-
1 Genome Replication and Transcription","RUNX1 regulates transcription of genes involved in BCR signaling","FGFR1 mutant receptor activation","MAP kinase activation","Regulation of TP53 Activity throu
gh Phosphorylation","Prolonged ERK activation events","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Regula
tion of TP53 Expression and Degradation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Loss of proteins required for interphase microtubule organiza
tion from the centrosome","NGF-independant TRKA activation","Activation of AMPK downstream of NMDARs","FCGR3A-mediated IL10 synthesis","Sema4D induced cell migration and growth-cone collapse","APC/C:C
dc20 mediated degradation of mitotic proteins","Separation of Sister Chromatids","Signalling to RAS","Replication of the SARS-CoV-1 genome","Signaling by activated point mutants of FGFR1","activated T
AK1 mediates p38 MAPK activation","MAPK targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","Ras activation upon Ca2+ influx through NMDA receptor","Regulation of TP53 Degradat
ion","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","p38MAPK events
","Activation of the AP-1 family of transcription factors","CREB phosphorylation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","APC-Cdc20 mediated degradation of Nek2A"}

> <broad_targets>
{NTRK1}

> <broad_moa>
{"growth factor receptor inhibitor"}

> <synonyms>
{"GW 441756",504433-23-2,504433232,GW441756,GW-441756,CHEMBL176544,"(3Z)-3-((1-methylindol-3-yl)methylidene)-1H-pyrrolo(3,2-b)pyridin-2-one","(3Z)3((1methylindol3yl)methylidene)1Hpyrrolo(3,2b)pyridin2
one",C17H13N3O,QCR-77,QCR77,SCHEMBL5787769,CHEBI:92072,SYN1044,HMS3303P17,HMS3305D02,HMS3884D22,504433-24-3,504433243,EX-A1842,EXA1842,ZINC398,SY-GW441756}

> <pdid>
PD003852

> <targets>
{"Trk receptor"}

> <classes>
{}

> <pubchem_cids>
{9943465}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 44  0  0  0  0            999 V2000
   10.7365   -4.8546    0.0000 Cl  0  0
    8.2365   -4.8546    0.0000 Cl  0  0
    5.7358   -9.9980    0.0000 C   0  0
    4.2445   -9.8362    0.0000 S   0  0
    3.3592  -11.0471    0.0000 O   0  0
    4.8503  -11.2085    0.0000 O   0  0
    3.6391   -8.4629    0.0000 C   0  0
    4.5250   -7.2514    0.0000 C   0  0
    3.9195   -5.8781    0.0000 N   0  0
    4.8054   -4.6666    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 S   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.6011   -3.0008    0.0000 N   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -7.8061   -5.9891    0.0000 O   0  0
   -7.8091   -7.4899    0.0000 C   0  0
   -9.1099   -8.2385    0.0000 C   0  0
   -9.1152   -9.7385    0.0000 C   0  0
  -10.4168  -10.4840    0.0000 C   0  0
  -11.7132   -9.7296    0.0000 C   0  0
  -11.7081   -8.2296    0.0000 C   0  0
  -13.0046   -7.4752    0.0000 F   0  0
  -10.4065   -7.4841    0.0000 C   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -7.7966   -2.9860    0.0000 Cl  0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  1  0
  4  5  2  0
  4  6  2  0
  4  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 11  2  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  1  0
 35 37  2  0
 37 31  1  0
 28 38  1  0
 38 39  1  0
 38 40  2  0
 40 25  1  0
 23 41  1  0
 41 19  1  0
 41 42  2  0
 42 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28284

> <plate>
Kinase v5-1

> <well>
G18

> <supplier_cmpd_name>
GW 583340 dihydrochloride

> <ctcr_id>
6282

> <supplier_cmpd_id>
2239

> <smiles>
Cl.Cl.C[S](=O)(=O)CCNCc1scc(n1)c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2

> <pd_targets>
{HSD17B10,RORC,EGFR,FFP,MAPK1,KDM4E,MAPT,KMT2A,MEN1,ALOX15,LEF,CYP3A4,ERBB2}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator","Other cytosolic protein",Oxidoreductase,"Nuclear receptor",Kinase,Transferase,Eraser,Reader,Protease,"Cytochrome P450","Nuclear hormone receptor 
subfamily 1","Protein Kinase","Lysine demethylase",Bromodomain,"Metallo protease","Cytochrome P450 family 3","Nuclear hormone receptor subfamily 1 group F","TK protein kinase group","CMGC protein kina
se group","Jumonji domain-containing","Metallo protease MAE clan","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase EGFR family","CMGC protei
n kinase MAPK family","Metallo protease M34 family","Cytochrome P450 3A4","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Catalytic receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","1F. Retinoic acid-related orphans","R
eceptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","1.14.11.- Histone demethylases",Lipoxygenases,"CYP3 family","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","R
eceptor tyrosine kinases (RTKs)","ERK subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{Metabolism,"Gene expression (Transcription)","Signal Transduction","Immune System","Neuronal System",Disease,"Developmental Biology","Metabolism of amino acids and derivatives","RNA Polymerase II Tra
nscription","Signaling by GPCR","Innate Immune System","Transmission across Chemical Synapses","Metabolism of lipids","Infectious disease","Nervous system development","Branched-chain amino acid catab
olism","Generic Transcription Pathway","GPCR downstream signalling","Toll-like Receptor Cascades","Neurotransmitter receptors and postsynaptic signal transmission","Biosynthesis of specialized proreso
lving mediators (SPMs)","Uptake and actions of bacterial toxins","Axon guidance","Transcriptional regulation by RUNX3","G alpha (q) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Activation
 of NMDA receptors and postsynaptic events","Biosynthesis of DPA-derived SPMs","Uptake and function of anthrax toxins","Biosynthesis of DHA-derived SPMs","Semaphorin interactions","RUNX3 Regulates Imm
une Response and Cell Migration","Gastrin-CREB signalling pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Post NMDA receptor activation events","Biosynthesis of DPAn-3 SPMs","B
iosynthesis of maresins","Sema4D in semaphorin signaling","EGFR Transactivation by Gastrin","MAP kinase activation","Activation of AMPK downstream of NMDARs","Biosynthesis of DPAn-3-derived protectins
 and resolvins","Biosynthesis of maresin-like SPMs","Sema4D induced cell migration and growth-cone collapse","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactiv
ated"}

> <broad_targets>
{EGFR,ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{"GW 583340 dihydrochloride",GW583340,1173023-85-2,1173023852,"GW 583340","GW583340 dihydrochloride",GW583340Dihydrochloride,GTPL4947,SCHEMBL9988095,CHEMBL1356199,AKOS024457005,NCGC00092346-01,NCGC000
9234601,EC-000.2408,EC000.2408,">=97 (H",2239}

> <pdid>
PD070626

> <targets>
{EGFR}

> <classes>
{}

> <pubchem_cids>
{16219404}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0
    3.8994    3.7478    0.0000 C   0  0
    5.1973    2.9959    0.0000 O   0  0
    1.2990    3.7500    0.0000 C   0  0
    1.2990    5.2500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2990   -5.2500    0.0000 O   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  5  8  2  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 11  3  1  0
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  2  3
 20  2  1  0
 20 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28285

> <plate>
Kinase v5-1

> <well>
G20

> <supplier_cmpd_name>
Ro 08-2750

> <ctcr_id>
4562

> <supplier_cmpd_id>
2272

> <smiles>
CN1c2cc(C=O)c(C)cc2N=C3C(=O)NC(=O)N=C13

> <pd_targets>
{RECQL,MAPT,BLM,NTRK1,ALD,NGF,TDP2,KMT2A,MEN1,RORC}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Secreted protein","Epigenetic regulator","Transcription factor",Kinase,Phosphodiesterase,Reader,"Nuclear receptor",Protease,"Protein Kinase",Bromodomain,"Nuclear hor
mone receptor subfamily 1","Cysteine protease","TK protein kinase group","Nuclear hormone receptor subfamily 1 group F","Cysteine protease CA clan","Tyrosine protein kinase Trk family","Nuclear hormon
e receptor subfamily 1 group F member 3","Cysteine protease C1A family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Nuclear hormone receptors","Receptor kinases","1F. Retinoic acid-related orphans","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type VII RTKs: Neurotrophi
n receptor/Trk family"}

> <pathway_reactome>
{"Neuronal System","DNA Repair","Signal Transduction","Gene expression (Transcription)","Transmission across Chemical Synapses","DNA Double-Strand Break Repair","Signaling by Receptor Tyrosine Kinases
","RNA Polymerase II Transcription","Neurotransmitter receptors and postsynaptic signal transmission","Homology Directed Repair","Signaling by NTRKs","Nonhomologous End-Joining (NHEJ)","Generic Transc
ription Pathway","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Signaling by NTRK1 (TRKA)","Transcriptional regul
ation by RUNX3","Post NMDA receptor activation events","HDR through Homologous Recombination (HRR)","Signalling to ERKs","RUNX3 Regulates Immune Response and Cell Migration","Activation of AMPK downst
ream of NMDARs","Homologous DNA Pairing and Strand Exchange","Prolonged ERK activation events","Presynaptic phase of homologous DNA pairing and strand exchange","ARMS-mediated activation"}

> <broad_targets>
{NGF,NGFR}

> <broad_moa>
{"NGF binding inhibitor"}

> <synonyms>
{"O 08275","Ro 08-2750","Ro 082750",37854-59-4,37854594,CHEMBL1397270,"7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo(g)pteridine-8-carbaldehyde","7,10dimethyl2,4dioxo2,3,4,10tetrahydrobenzo(g)pteri
dine8carbaldehyde","7,10-dimethyl-2,4-dioxobenzo(g)pteridine-8-carbaldehyde","7,10dimethyl2,4dioxobenzo(g)pteridine8carbaldehyde","7,10-dimethyl-2,4-dioxo-8-benzo(g)pteridinecarboxaldehyde","7,10dimet
hyl2,4dioxo8benzo(g)pteridinecarboxaldehyde",SCHEMBL1,2272}

> <pdid>
PD021729

> <targets>
{RTKs,TrkR,TrkA,Apoptosis}

> <classes>
{Apoptosis}

> <pubchem_cids>
{17756791}

$$$$
UTKinase_V5
  SciTegic11012413002D

 13 14  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Br  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 Br  0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Br  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Br  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11  7  1  0
 11 12  2  0
 12  2  1  0
 12 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28286

> <plate>
Kinase v5-1

> <well>
G22

> <supplier_cmpd_name>
TBB

> <ctcr_id>
1346

> <supplier_cmpd_id>
2275

> <smiles>
Brc1c(Br)c(Br)c2nn[nH]c2c1Br

> <pd_targets>
{CSNK2A1,CSNK2A2,CSNK2B,FTL,LMNA,KDM4E,ALOX15,HPGD,CYP3A4,DYRK1A,NQO2,REP,KMT2A,MEN1,THPO,NS3,GMNN,RECQL,NFKB1,ALDH1A1,BLM,CSNK2A3,MAPT,HSD17B10}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Other nuclear protein","Epigenetic regulator","Other cytosolic protein",Kinase,Eraser,Oxidoreductase,"Cytochrome P450",Transferase,Reader,Protease,"Protein Kinase","Lys
ine demethylase","Cytochrome P450 family 3",Bromodomain,"Serine protease","Other protein kinase group","Jumonji domain-containing","Cytochrome P450 family 3A","CMGC protein kinase group","Serine prote
ase PA clan","Other protein kinase CK2 family","Cytochrome P450 3A4","CMGC protein kinase DYRK family","Serine protease S29 family","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","Anti-infective targets","Receptor kinases
","1.14.11.- Histone demethylases",Lipoxygenases,"Prostaglandin synthases","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Viral protein targets","Other protein kinases","Dual-specifici
ty tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Coronavirus (CoV) proteins","Casein kinase 2 (CK2) family","Dyrk1 subfamily"}

> <pathway_reactome>
{"Vesicle-mediated transport","Gene expression (Transcription)","Cell Cycle",Metabolism,Disease,Hemostasis,"Immune System","DNA Repair","Neuronal System","Membrane Trafficking","RNA Polymerase II Tran
scription",Mitotic,"Metabolism of lipids","Biological oxidations","Infectious disease","Platelet activation","signaling and aggregation","Cytokine Signaling in Immune system","DNA Double-Strand Break 
Repair","Transmission across Chemical Synapses","Metabolism of amino acids and derivatives","trans-Golgi Network Vesicle Budding","Generic Transcription Pathway","M Phase","Biosynthesis of specialized
 proresolving mediators (SPMs)","Mitotic G1 phase and G1/S transition","Phase I - Functionalization of compounds","SARS-CoV Infections","Platelet Aggregation (Plug Formation)","Signaling by Interleuki
ns","Homology Directed Repair","Neurotransmitter receptors and postsynaptic signal transmission","Branched-chain amino acid catabolism","Golgi Associated Vesicle Biogenesis","Transcriptional Regulatio
n by TP53","Mitotic Metaphase and Anaphase","Biosynthesis of DPA-derived SPMs","Biosynthesis of DHA-derived SPMs","G0 and Early G1","SARS-CoV-2 Infection","G1/S Transition","Interleukin-1 family signa
ling","Ethanol oxidation","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Activation of NMDA receptors and postsynaptic events","Regulation of TP53 Activity","Mitotic An
aphase","Biosynthesis of DPAn-3 SPMs","Biosynthesis of D-series resolvins","Biosynthesis of maresins","SARS-CoV-2 Genome Replication and Transcription","Activation of the pre-replicative complex","Int
erleukin-1 signaling","HDR through Homologous Recombination (HRR)","Post NMDA receptor activation events","Regulation of TP53 Activity through Phosphorylation","Nuclear Envelope (NE) Reassembly","Bios
ynthesis of DPAn-3-derived protectins and resolvins","Biosynthesis of maresin-like SPMs","Replication of the SARS-CoV-2 genome","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Homologous DNA Pairing and
 Strand Exchange","Activation of AMPK downstream of NMDARs","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{17374-26-4,17374264,"4,5,6,7-tetrabromobenzotriazole","4,5,6,7tetrabromobenzotriazole",TBB,"4,5,6,7-Tetrabromo-1H-benzotriazole","4,5,6,7Tetrabromo1Hbenzotriazole",TBBt,"4,5,6,7-tetrabromo-2H-benzotr
iazole","4,5,6,7tetrabromo2Hbenzotriazole","4,5,6,7-Tetrabromo-1H-benzo(d)(1,2,3)triazole","4,5,6,7Tetrabromo1Hbenzo(d)(1,2,3)triazole",TETRABROMO-2-BENZOTRIAZOLE,TETRABROMO2BENZOTRIAZOLE,"4,5,6,7-Tet
rabromo-2-azabenzimidazole","4,5,6,7Tetrabromo2azabenzimidazole",Ca,2275,"EMD 218697",218697}

> <pdid>
PD002647

> <targets>
{"Casein Kinase II Inhibitor I",CK2}

> <classes>
{}

> <pubchem_cids>
{1694}

$$$$
UTKinase_V5
  SciTegic11012413002D

 12 12  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Br  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 Br  0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Br  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Br  0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Br  0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Br  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  1  0
 11  2  1  0
 11 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28287

> <plate>
Kinase v5-1

> <well>
I04

> <supplier_cmpd_name>
1,2,3,4,5,6-Hexabromocyclohexane

> <ctcr_id>
372

> <supplier_cmpd_id>
2291

> <smiles>
BrC1C(Br)C(Br)C(Br)C(Br)C1Br

> <pd_targets>
{GABRB3,GABRA1,GABRB1,GABRR1,RDL,GABRA6,GABRG2,AR,823,298,382,338,688,000,RDL1,RDL2,RDL3,GLRA1,GLRA2,GLRA3,GLRB,LMNA,CYP3A4}

> <pathway_gtopdb>
{"Ion channel","Transcription factor","Other nuclear protein",Enzyme,"Ligand-gated ion channel","Nuclear receptor","Cytochrome P450","GABA-A receptor","Nuclear hormone receptor subfamily 3","Glycine r
eceptor","Cytochrome P450 family 3","Nuclear hormone receptor subfamily 3 group C","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 3 group C member 4","Cytochrome P450 3A4"}

> <pathway_chembl>
{"Ion channels",Receptors,Enzymes,"Ligand-gated ion channels","Nuclear hormone receptors","Cytochrome P450","GABA<sub>A</sub> receptors","Steroid hormone receptors","Glycine receptors","CYP3 family","
3C. 3-Ketosteroid receptors"}

> <pathway_reactome>
{"Neuronal System","Gene expression (Transcription)","Cell Cycle",Metabolism,"Transmission across Chemical Synapses","RNA Polymerase II Transcription",Mitotic,"Metabolism of lipids","Neurotransmitter 
receptors and postsynaptic signal transmission","Generic Transcription Pathway","M Phase","Biosynthesis of specialized proresolving mediators (SPMs)","GABA receptor activation","Transcriptional regula
tion by RUNX2","Mitotic Metaphase and Anaphase","Biosynthesis of DHA-derived SPMs","RUNX2 regulates bone development","Mitotic Anaphase","Biosynthesis of maresins","RUNX2 regulates osteoblast differen
tiation","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","Initiation of Nuclear Envelope (NE) Reformation"}

> <broad_targets>
{JAK2}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{83791,"1,2,3,4,5,6-Hexabromocyclohexane","1,2,3,4,5,6Hexabromocyclohexane",1837-91-8,1837918,"Benzene hexabromide","Cyclohexane, 1,2,3,4,5,6-hexabromo-","Cyclohexane, 1,2,3,4,5,6hexabromo",Hexabromoc
yclohexane,"JAK2 Inhibitor II",ACMC-1BQJT,ACMC1BQJT,SCHEMBL459442,"trans-alpha-Benzene hexabromide","transalphaBenzene hexabromide",CHEMBL444236,DTXSID4052687,CHEBI:93940,N,T0854,2291,Lindane}

> <pdid>
PD002551

> <targets>
{JAK2}

> <classes>
{}

> <pubchem_cids>
{74603}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 23  0  0  0  0            999 V2000
    5.0987   -1.2614    0.0000 Cl  0  0
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8978   -0.7496    0.0000 S   0  0
   -3.8974    0.7504    0.0000 O   0  0
   -2.5987    0.0002    0.0000 O   0  0
   -5.1981   -1.4992    0.0000 N   0  0
   -5.1012   -3.0033    0.0000 C   0  0
   -6.2014   -4.0229    0.0000 C   0  0
   -7.6846   -3.7984    0.0000 C   0  0
   -8.4337   -2.4989    0.0000 N   0  0
   -7.8848   -1.1029    0.0000 C   0  0
   -6.4512   -0.6617    0.0000 C   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 12 13  1  0
 13 14  2  0
 13 15  2  0
 13 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28288

> <plate>
Kinase v5-1

> <well>
I06

> <supplier_cmpd_name>
HA 1100 hydrochloride

> <ctcr_id>
1032

> <supplier_cmpd_id>
2415

> <smiles>
Cl.Oc1nccc2c1cccc2[S](=O)(=O)N3CCCNCC3

> <pd_targets>
{ALDH1A1,KCNH2,PRKACA,ROCK1,HPGD,ROCK2,PRKACB,PRKACG,CCL2}

> <pathway_gtopdb>
{Enzyme,"Ion channel","Membrane receptor",Oxidoreductase,"Voltage-gated ion channel",Kinase,Protease,"Family A G protein-coupled receptor","Potassium channels","Protein Kinase","Cysteine protease","Pe
ptide receptor (family A GPCR)","Voltage-gated potassium channel","AGC protein kinase group","Cysteine protease CA clan","Chemokine receptor","AGC protein kinase PKA family","AGC protein kinase DMPK f
amily","Cysteine protease C1A family","CC chemokine receptor","AGC protein kinase ROCK subfamily"}

> <pathway_chembl>
{"Ion channels",Enzymes,"Voltage-gated ion channels","Kinases (EC 2.7.x.x)","Eicosanoid turnover","Potassium channels","AGC: Containing PKA",PKG,"PKC families","Prostaglandin synthases","Voltage-gated
 potassium channels","Protein kinase A (PKA) family","DMPK family","Rho kinase"}

> <pathway_reactome>
{Metabolism,"Muscle contraction","Cell Cycle","Developmental Biology","Signal Transduction","Biological oxidations","Cardiac conduction",Mitotic,"Nervous system development","Metabolism of lipids","Si
gnaling by GPCR","Phase I - Functionalization of compounds","Phase 3 - rapid repolarisation","Mitotic G2-G2/M phases","Axon guidance","Biosynthesis of specialized proresolving mediators (SPMs)","GPCR 
ligand binding","Ethanol oxidation","G2/M Transition","Semaphorin interactions","Biosynthesis of DHA-derived SPMs","Class A/1 (Rhodopsin-like receptors)","Centrosome maturation","Sema4D in semaphorin 
signaling","Biosynthesis of D-series resolvins","Peptide ligand-binding receptors","Loss of proteins required for interphase microtubule organization from the centrosome","Sema4D induced cell migratio
n and growth-cone collapse","Chemokine receptors bind chemokines","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Hydroxyfasudil Hydrochloride",155558-32-0,155558320,"HA 1100 hydrochloride","Hydroxyfasudil HCl","Hydroxyfasudil (hydrochloride)","1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine Hydrochloride","
1(1Hydroxy5isoquinolinesulfonyl)homopiperazine Hydrochloride","HA-1100 hydrochloride;HA 1100 hydrochlorid","HA1100 hydrochloride;HA 1100 hydrochlorid",2415}

> <pdid>
PD005885

> <targets>
{ROCK}

> <classes>
{}

> <pubchem_cids>
{11371328}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 30  0  0  0  0            999 V2000
    8.8915   -3.0024    0.0000 Cl  0  0
    6.3915   -3.0024    0.0000 Cl  0  0
    2.5795   -7.5040    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.6011   -3.0008    0.0000 N   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -7.8069   -5.9860    0.0000 F   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -7.7966   -2.9860    0.0000 Cl  0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  1  0
 25 27  2  0
 27 20  1  0
 18 28  1  0
 28 14  1  0
 28 29  2  0
 29 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28289

> <plate>
Kinase v5-1

> <well>
I08

> <supplier_cmpd_name>
BIBX 1382 dihydrochloride

> <ctcr_id>
70

> <supplier_cmpd_id>
2416

> <smiles>
Cl.Cl.CN1CCC(CC1)Nc2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2

> <pd_targets>
{ERBB2,EGFR,HTT,HPGD}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Eicosanoid turnover","Receptor kinases","Prostaglandin synthases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growt
h factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction","Gene expression (Transcription)",Metabolism,"Nervous system development","Signaling by GPCR","RNA Polymerase II Transcription","Metabolism of lipids","A
xon guidance","GPCR downstream signalling","Generic Transcription Pathway","Biosynthesis of specialized proresolving mediators (SPMs)","Semaphorin interactions","G alpha (q) signalling events","Transc
riptional Regulation by MECP2","Biosynthesis of DHA-derived SPMs","Sema4D in semaphorin signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Regulation of MECP2 expression and activity","Bio
synthesis of D-series resolvins","Sema4D induced cell migration and growth-cone collapse","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR,ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{"BIBX 1382 DIHYDROCHLORIDE",1216920-18-1,1216920181,"Falnidamol dihydrochloride",DSSTox_CID_26307,DSSToxCID26307,DSSTox-CID-26307,"DSSTox CID 26307",DSSTox_RID_81528,DSSToxRID81528,DSSTox-RID-81528,"
DSSTox RID 81528",DSSTox_GSID_46307,DSSToxGSID46307,DSSTox-GSID-46307,"DSSTox GSID 46307",CAS-1216920-18-1,CAS1216920181,NCGC00161422-01,NCGC0016142201,BIBX1382Dihydrochloride,CHEMBL2136050,DTXSID0046
307,Tox21_111996,Tox21111996,Tox21-111996,"Tox21 111996",AKOS015,2416,"BIBX 1382 dihydrochloride"}

> <pdid>
PD012960

> <targets>
{EGFR}

> <classes>
{}

> <pubchem_cids>
{46861540}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    7.7884    1.5181    0.0000 F   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
    0.6923    4.0811    0.0000 O   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -2.4133    1.7530    0.0000 C   0  0
   -3.8805    1.4409    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2089   -5.9859    0.0000 F   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15  9  2  0
 15 16  1  0
 16 17  2  0
 17  7  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
  5 26  1  0
 26 27  2  0
 27  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28290

> <plate>
Kinase v5-1

> <well>
I10

> <supplier_cmpd_name>
CGP 53353

> <ctcr_id>
175

> <supplier_cmpd_id>
2442

> <smiles>
Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc4ccc(F)cc4)cc1

> <pd_targets>
{RORC,EGFR,KMT2A,MEN1,PRKCB,FFP,SRC,MAPT,PRKCA,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,PDGFRA,PDGFRB}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator","Other cytosolic protein","Nuclear receptor",Kinase,Reader,Transferase,"Nuclear hormone receptor subfamily 1","Protein Kinase",Bromodomain,"Nuclea
r hormone receptor subfamily 1 group F","TK protein kinase group","AGC protein kinase group","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase EGFR family","AGC protein 
kinase PKC family","Tyrosine protein kinase Src family","Tyrosine protein kinase PDGFR family","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Catalytic receptors","Kinases (EC 2.7.x.x)","1F. Retinoic acid-related orphans","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","TK: Tyrosin
e kinase","Protein kinase C (PKC) family","Receptor tyrosine kinases (RTKs)","Alpha subfamily","Non-receptor tyrosine kinases (nRTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family","Sr
c family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Cell Cycle","Neuronal System","RNA Polymerase II Transcription","Signaling by GPCR",Mitotic,"Signaling by Receptor Tyrosine Kinases","Transmis
sion across Chemical Synapses","Generic Transcription Pathway","GPCR downstream signalling","M Phase","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Transcript
ional regulation by RUNX3","G alpha (q) signalling events","Mitotic Prophase","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","RUNX3 Regulates Immune Response and Ce
ll Migration","Gastrin-CREB signalling pathway via PKC and MAPK","Nuclear Envelope Breakdown","Signalling to ERKs","Post NMDA receptor activation events","EGFR Transactivation by Gastrin","Depolymeris
ation of the Nuclear Lamina","Signalling to RAS","Activation of AMPK downstream of NMDARs","p38MAPK events"}

> <broad_targets>
{EGFR,PRKCB}

> <broad_moa>
{"EGFR inhibitor","PKC inhibitor"}

> <synonyms>
{145915-60-2,145915602,"145915 60 2","CGP 53353",CGP-53353,CGP53353,"DAPH 2","5,6-BIS((4-FLUOROPHENYL)AMINO)-1H-ISOINDOLE-1,3(2H)-DIONE","5,6BIS((4FLUOROPHENYL)AMINO)1HISOINDOLE1,3(2H)DIONE",5,"6 BIS(
(4 FLUOROPHENYL)AMINO) 1H ISOINDOLE 1",3(2H),"EMD 539652",2442,539652}

> <pdid>
PD021711

> <targets>
{"Protein Kinase C",PKC}

> <classes>
{}

> <pubchem_cids>
{6711154}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 30  0  0  0  0            999 V2000
    3.1882    2.6402    0.0000 O   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 N   0  0
    2.7248   -1.2135    0.0000 C   0  0
    3.1882   -2.6401    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.4135    4.4923    0.0000 C   0  0
   -1.5318    5.7059    0.0000 C   0  0
   -0.0400    5.5491    0.0000 C   0  0
    0.5701    4.1788    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.4134   -4.4924    0.0000 C   0  0
   -1.5318   -5.7059    0.0000 C   0  0
   -0.0400   -5.5491    0.0000 C   0  0
    0.5701   -4.1788    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  8  1  0
 16 11  1  0
  9 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 24 25  1  0
 25  6  1  0
 25 17  2  0
M  END
> <name>
UTKinase_V5

> <id>
28291

> <plate>
Kinase v5-1

> <well>
I12

> <supplier_cmpd_name>
Arcyriaflavin A

> <ctcr_id>
1117

> <supplier_cmpd_id>
2457

> <smiles>
O=C1NC(=O)c2c1c3c([nH]c4ccccc34)c5[nH]c6ccccc6c25

> <pd_targets>
{CCNB1,CCNB2,CCNB3,CDK1,KMT2A,MEN1,MAPT,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,CCNE1,CCNE2,CDK2,CCND1,CDK4,PRKACA,PRKACB,PRKACG,CCNA2,CAMK2A,CAMK2B,CAMK2D,CAMK2G,CDK5,CDK5R1
}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein",Kinase,Reader,Protease,"Protein Kinase",Bromodomain,"Cysteine protease","CMGC protein kinase group","AGC protein kinase group","Cysteine protea
se CA clan","CAMK protein kinase group","CMGC protein kinase CDK family","AGC protein kinase PKC family","Cysteine protease C1A family","AGC protein kinase PKA family","CAMK protein kinase CAMK2 famil
y","CMGC protein kinase CDC2 subfamily","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Protein kinase C (PKC) family","Protein kinase A (PKA) family","Delta subfamily"}

> <pathway_reactome>
{"Neuronal System","Signal Transduction","Cell Cycle","Transmission across Chemical Synapses","Signaling by GPCR",Mitotic,"Neurotransmitter receptors and postsynaptic signal transmission","GPCR downst
ream signalling","Mitotic G2-G2/M phases","Activation of NMDA receptors and postsynaptic events","G alpha (i) signalling events","G2/M Transition","Post NMDA receptor activation events","Visual photot
ransduction","Centrosome maturation","Activation of AMPK downstream of NMDARs","The phototransduction cascade","Loss of proteins required for interphase microtubule organization from the centrosome",I
nactivation,"recovery and regulation of the phototransduction cascade","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{CCND1,CDK4}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{"arcyriaflavin a",118458-54-1,118458541,"12,13-Dihydro-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione","12,13Dihydro5Hindolo(2,3a)pyrrolo(3,4c)carbazole5,7(6H)dione",CHEMBL268368,LSM-3627,LSM3
627,"Arcyriaflavin A, Synthetic",arcyriaflavin-a,arcyriaflavina,"STAUROSPORINE AGLYCON",BDBM2672,SCHEMBL8124103,CHEBI:93276,DTXSID5041613,2457,"EMD 181305","Arcyriaflavin A",181305}

> <pdid>
PD038554

> <targets>
{"Cyclin-dependent Kinase",cdk,"Arcyriaflavin A",Synthetic}

> <classes>
{}

> <pubchem_cids>
{5327723}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2982    3.7531    0.0000 N   0  0
    1.2960    5.2539    0.0000 C   0  0
    2.5925    6.0085    0.0000 C   0  0
    2.5873    7.5085    0.0000 C   0  0
    1.2856    8.2540    0.0000 C   0  0
    1.2773    9.7548    0.0000 N   0  0
   -0.0261   10.4989    0.0000 C   0  0
   -1.3212    9.7421    0.0000 O   0  0
   -0.0344   11.9997    0.0000 C   0  0
   -1.3360   12.7452    0.0000 C   0  0
   -1.3412   14.2452    0.0000 C   0  0
   -0.0448   14.9997    0.0000 C   0  0
    1.2568   14.2543    0.0000 C   0  0
    1.2621   12.7543    0.0000 C   0  0
   -0.0108    7.4995    0.0000 C   0  0
   -0.0056    5.9995    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 N   0  0
   -3.9099   -8.2497    0.0000 C   0  0
   -3.9099   -9.7497    0.0000 C   0  0
   -2.6109  -10.4997    0.0000 O   0  0
   -1.3119   -9.7497    0.0000 C   0  0
   -1.3118   -8.2497    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 11 21  1  0
 21 22  2  0
 22  8  1  0
  6 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26  5  1  0
 26 27  1  0
 27 28  2  0
 28  3  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28292

> <plate>
Kinase v5-1

> <well>
I14

> <supplier_cmpd_name>
ZM 447439

> <ctcr_id>
2962

> <supplier_cmpd_id>
2458

> <smiles>
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN5CCOCC5

> <pd_targets>
{LCK,TNK2,AURKA,RORC,ROCK2,AURKB,RET,KDR,MET,EGFR,MAPT,TYRO3,BTK,PDGFRA,NTRK2,ALDH1A1,AURKB-A,FYN,LTK,MAP2K2,MAP4K5,MAP2K1}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Other cytosolic protein",Kinase,"Nuclear receptor",Oxidoreductase,"Protein Kinase","Nuclear hormone receptor subfamily 1","TK protein kinase group","Other protein kinas
e group","Nuclear hormone receptor subfamily 1 group F","AGC protein kinase group","STE protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase Ack family","Other protein k
inase AUR family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase DMPK family","Tyrosine protein kinase Ret family","Tyrosine protein kinase VEGFR family","Tyrosine protein
 kinase Met family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Tec family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Trk 
family","Tyrosine protein kinase Alk family","STE protein kinase STE7 family","STE protein kinase STE20 family","AGC protein kinase ROCK subfamily","Tyrosine protein kinase SrcA","STE protein kinase K
HS subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Receptor kinases","1F. Retinoic acid-related orphans","AGC: Containing PKA",PKG,"PKC families","STE: Homolo
gs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","Other protein kinases","DMPK family","STE7 family","STE20 family","Non-receptor tyrosine kinases (nRTKs)","Aurora kinase
 (Aur) family","Rho kinase","Receptor tyrosine kinases (RTKs)","KHS subfamily","Src family","Ack family","Type XIV RTKs: RET","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family",
"Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Tec family",
"Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Developmental Biology","Cell Cycle","Signal Transduction","Neuronal System",Metabolism,"Infectious disease","RNA Polymerase II Transcription","Nervous syste
m development",Mitotic,"Signaling by Receptor Tyrosine Kinases","Signaling by GPCR","Transmission across Chemical Synapses","Diseases of signal transduction by growth factor receptors and second messe
ngers","Biological oxidations","HIV Infection","Generic Transcription Pathway","Axon guidance","M Phase","Signaling by VEGF","GPCR downstream signalling","Neurotransmitter receptors and postsynaptic s
ignal transmission","Leishmania infection","Signaling by PDGFR in disease","Signaling by NTRKs","Phase I - Functionalization of compounds","Host Interactions of HIV factors","Transcriptional Regulatio
n by TP53","Transcriptional regulation by RUNX3","Semaphorin interactions","Mitotic Metaphase and Anaphase","RET signaling","VEGFA-VEGFR2 Pathway","G alpha (q) signalling events","Activation of NMDA r
eceptors and postsynaptic events","Parasite infection","Drug resistance of PDGFR mutants","Signaling by NTRK1 (TRKA)","Ethanol oxidation","The role of Nef in HIV-1 replication and disease pathogenesis
","Regulation of TP53 Activity","RUNX3 Regulates Immune Response and Cell Migration","Sema4D in semaphorin signaling","Mitotic Anaphase","VEGFR2 mediated cell proliferation","Gastrin-CREB signalling p
athway via PKC and MAPK","Post NMDA receptor activation events","Leishmania phagocytosis","Imatinib-resistant PDGFR mutants","Activation of TRKA receptors","Signalling to ERKs","Nef-mediates down modu
lation of cell surface receptors by recruiting them to clathrin adapters","Regulation of TP53 Activity through Phosphorylation","Sema4D induced cell migration and growth-cone collapse","Separation of 
Sister Chromatids","Sema4D mediated inhibition of cell attachment and migration","EGFR Transactivation by Gastrin","Activation of AMPK downstream of NMDARs","FCGR3A-mediated phagocytosis","NGF-indepen
dant TRKA activation","Nef and signal transduction","Prolonged ERK activation events","Nef Mediated CD4 Down-regulation","Frs2-mediated activation"}

> <broad_targets>
{AURKA,AURKB}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{331771-20-1,331771201,ZM-447439,ZM447439,"ZM 447439",TCMDC-125873,TCMDC125873,UNII-RSN3P9776R,UNIIRSN3P9776R,CHEMBL202721,RSN3P9776R,C29H31N5O4,Kinome_3319,Kinome3319,Kinome-3319,"Kinome 3319",NCGC00
159574-01,NCGC0015957401,PubChem24158,cc-90,cc90,MLS006010133,SCHEMBL597105,GTPL8353,BDBM14210,CHEBI:91376,AOB2181,DTXSID00186833,BCPP000002,S1103,2458}

> <pdid>
PD011136

> <targets>
{Aurora,"AURORA KINASE B"}

> <classes>
{}

> <pubchem_cids>
{9914412}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 30  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5950   -3.0008    0.0000 C   0  0
   -1.2942   -3.7494    0.0000 C   0  0
   -1.2911   -5.2502    0.0000 C   0  0
    0.0091   -5.9984    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    6.3987    0.3760    0.0000 O   0  0
    6.3987   -1.1240    0.0000 C   0  0
    5.0994   -1.8736    0.0000 O   0  0
    7.6987   -1.8740    0.0000 C   0  0
    8.9987   -1.1240    0.0000 C   0  0
   10.2987   -1.8740    0.0000 C   0  0
   11.5980   -1.1244    0.0000 O   0  0
   10.2987   -3.3740    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 14 19  1  0
 19  5  1  0
 19 20  2  0
 20  2  1  0
 20 21  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  2  3
 26 27  1  0
 27 28  2  0
 27 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28293

> <plate>
Kinase v5-1

> <well>
I16

> <supplier_cmpd_name>
ER 27319 maleate

> <ctcr_id>
3327

> <supplier_cmpd_id>
2471

> <smiles>
Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C.OC(=O)C=CC(=O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{1204480-26-1,1204480261,2471,"ER 27319 maleate"}

> <pdid>

> <targets>
{"Syk Kinase",Syk}

> <classes>
{}

> <pubchem_cids>
{71433966}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
   10.2891   -2.6236    0.0000 Cl  0  0
    7.7884    1.5181    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    5.2059   -2.9909    0.0000 F   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8963   -3.7531    0.0000 O   0  0
   -3.8941   -5.2539    0.0000 C   0  0
   -5.1923   -6.0070    0.0000 C   0  0
   -5.1924   -7.5071    0.0000 C   0  0
   -6.4914   -8.2571    0.0000 C   0  0
   -7.7905   -7.5071    0.0000 C   0  0
   -7.7905   -6.0071    0.0000 C   0  0
   -6.4915   -5.2571    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    5.1852    3.0091    0.0000 O   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 15 24  2  0
 24 25  1  0
 25 26  2  0
 26  9  1  0
 26 13  1  0
  7 27  1  0
 27 28  2  0
 28  3  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28294

> <plate>
Kinase v5-1

> <well>
I18

> <supplier_cmpd_name>
ZM 323881 hydrochloride

> <ctcr_id>
6639

> <supplier_cmpd_id>
2475

> <smiles>
Cl.Cc1cc(F)c(Nc2ncnc3cc(OCc4ccccc4)ccc23)cc1O

> <pd_targets>
{KDR,MAPT}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein",Kinase,Protease,"Protein Kinase","Cysteine protease","TK protein kinase group","Cysteine protease CA clan","Tyrosine protein kinase VEGFR family","Cysteine protease C
1A family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System","Signaling by Receptor Tyrosine Kinases","Transmission across Chemical Synapses","Signaling by VEGF","Neurotransmitter receptors and postsynaptic signal transm
ission","VEGFA-VEGFR2 Pathway","Activation of NMDA receptors and postsynaptic events","VEGFR2 mediated cell proliferation","Post NMDA receptor activation events","Activation of AMPK downstream of NMDA
Rs"}

> <broad_targets>
{KDR}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{193000-39-4,193000394,"193000 39 4","ZM323881 hydrochloride",324077-30-7,324077307,"324077 30 7","ZM323881 (hydrochloride)","ZM 323881 HCl","5-((7-BENZYLOXYQUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHE
NOL HYDROCHLORIDE","5((7BENZYLOXYQUINAZOLIN4YL)AMINO)4FLUORO2METHYLPHENOL HYDROCHLORIDE","5 ((7 BENZYLOXYQUINAZOLIN 4 YL)AMINO) 4 FLUORO 2 METHYLPHENOL HYDROCHLORIDE","ZM323881 HCl","193000-39-4 (HCl)
","193000394 (HCl)","193000 39 4 (HCl)",C22H19Cl,T1991,2475,S2896,"ZM 323881 hydrochloride"}

> <pdid>
PD070764

> <targets>
{VEGFR}

> <classes>
{Protein Tyrosine Kinase,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{22624897}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 25  0  0  0  0            999 V2000
    6.3990    0.0095    0.0000 Cl  0  0
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -5.1930    3.0046    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0875    3.7680    0.0000 Cl  0  0
   -7.7962    1.5135    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -6.5050   -0.7409    0.0000 F   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18 12  1  0
 18 19  1  0
 10 20  2  0
 20  6  1  0
 20 21  1  0
 21 22  2  0
 22  4  1  0
 22 23  1  0
 23 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28295

> <plate>
Kinase v5-1

> <well>
I20

> <supplier_cmpd_name>
ZM 306416 hydrochloride

> <ctcr_id>
3117

> <supplier_cmpd_id>
2499

> <smiles>
Cl.COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC

> <pd_targets>
{FLT1,EPHB2,KDR,FGFR1,FLT4,EGFR,SRC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Eph family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase EGF
R family","Tyrosine protein kinase Src family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XIII RTKs: 
Ephrin receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Non-receptor tyrosine kinases (nRTKs)","Src family"
}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology",Disease,"Signaling by Receptor Tyrosine Kinases","Nervous system development","Diseases of signal transduction by growth factor receptors and second mess
engers","Signaling by GPCR","Signaling by VEGF","Axon guidance","Signaling by FGFR in disease","GPCR downstream signalling","VEGF ligand-receptor interactions","EPH-Ephrin signaling","VEGFA-VEGFR2 Pat
hway","Signaling by FGFR1 in disease","G alpha (q) signalling events","VEGF binds to VEGFR leading to receptor dimerization","EPHB-mediated forward signaling","VEGFR2 mediated cell proliferation","FGF
R1 mutant receptor activation","Gastrin-CREB signalling pathway via PKC and MAPK","Signaling by activated point mutants of FGFR1","EGFR Transactivation by Gastrin","Signaling by NTRKs","Signaling by N
TRK1 (TRKA)","Signalling to ERKs","Signalling to RAS","p38MAPK events"}

> <broad_targets>
{EGFR,FLT1,FLT4,KDR}

> <broad_moa>
{"Abl kinase inhibitor","SRC inhibitor","VEGFR inhibitor"}

> <synonyms>
{"ZM 306416 hydrochloride",196603-47-1,196603471,"4-((4'-CHLORO-2'-FLUORO)PHENYLAMINO)-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE","4((4'CHLORO2'FLUORO)PHENYLAMINO)6,7DIMETHOXYQUINAZOLINE HYDROCHLORIDE","
N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride","N(4chloro2fluorophenyl)6,7dimethoxyquinazolin4amine;hydrochloride","ZM306416 hydrochloride",cc-700,cc700,SCHEM,2499}

> <pdid>
PD010526

> <targets>
{VEGFR}

> <classes>
{}

> <pubchem_cids>
{21701577}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 40  0  0  0  0            999 V2000
    7.1946   -3.9356    0.0000 Cl  0  0
   -5.3306   -9.0124    0.0000 O   0  0
   -4.4785   -7.7779    0.0000 C   0  0
   -5.1224   -6.4222    0.0000 N   0  0
   -6.6174   -6.2989    0.0000 C   0  0
   -7.2581   -4.9427    0.0000 C   0  0
   -6.4040   -3.7096    0.0000 C   0  0
   -4.9090   -3.8329    0.0000 C   0  0
   -4.2683   -5.1891    0.0000 C   0  0
   -7.0450   -2.3527    0.0000 N   0  0
   -8.5092   -2.0913    0.0000 C   0  0
   -8.6971   -0.6032    0.0000 C   0  0
   -7.3398    0.0355    0.0000 C   0  0
   -6.3131   -1.0580    0.0000 C   0  0
   -2.9826   -7.8991    0.0000 C   0  0
   -2.3371   -9.2532    0.0000 C   0  0
   -0.8418   -9.3712    0.0000 C   0  0
    0.0082   -8.1352    0.0000 C   0  0
    1.5046   -8.2503    0.0000 N   0  0
    2.3532   -7.0124    0.0000 C   0  0
    3.8490   -7.1253    0.0000 N   0  0
    4.6946   -5.8864    0.0000 C   0  0
    4.0445   -4.5346    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.7031   -5.6606    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 S   0  0
   -0.6374   -6.7812    0.0000 C   0  0
   -2.1327   -6.6631    0.0000 C   0  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 10  1  0
  3 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 24 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 33 34  1  0
 34 26  1  0
 18 35  1  0
 35 36  2  0
 36 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28296

> <plate>
Kinase v5-1

> <well>
I22

> <supplier_cmpd_name>
IKK 16

> <ctcr_id>
4483

> <supplier_cmpd_id>
2539

> <smiles>
Cl.O=C(N1CCC(CC1)N2CCCC2)c3ccc(Nc4nccc(n4)c5cc6ccccc6s5)cc3

> <pd_targets>
{IKBKB,CHUK,RECQL,BLM,FFP,RORC,IKBKG,PRKCZ}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,Transferase,"Nuclear receptor","Protein Kinase","Nuclear hormone receptor subfamily 1","Other protein kinase group","Nuclear hormone receptor subfamily 1 group F"
,"AGC protein kinase group","Other protein kinase IKK family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKC family","AGC protein kinase PKC iota subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Receptor kinases","1F. Retinoic acid-related orphans","AGC: Containing PKA",PKG,"PKC families","Other prote
in kinases","Protein kinase C (PKC) family","IKK family","Iota subfamily"}

> <pathway_reactome>
{"Immune System","DNA Repair","Gene expression (Transcription)","Signal Transduction","Innate Immune System","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Signaling by Nuclear Re
ceptors","Toll-like Receptor Cascades","Homology Directed Repair","Generic Transcription Pathway","ESR-mediated signaling","Toll Like Receptor 4 (TLR4) Cascade","HDR through Homologous Recombination (
HRR) or Single Strand Annealing (SSA)","Transcriptional regulation by RUNX3","Extra-nuclear estrogen signaling","MyD88-independent TLR4 cascade","HDR through Homologous Recombination (HRR)","RUNX3 Reg
ulates Immune Response and Cell Migration","Estrogen-stimulated signaling through PRKCZ","TRIF(TICAM1)-mediated TLR4 signaling","Homologous DNA Pairing and Strand Exchange","IKK complex recruitment me
diated by RIP1","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor"}

> <synonyms>
{1186195-62-9,1186195629,"1186195 62 9","IKK-16 HCl","IKK16 HCl","IKK 16 HCl","IKK 16 (hydrochloride)",IKK-16,IKK16,"IKK 16","IKK 16 hydrochloride","1186195-62-9 (HCl)","1186195629 (HCl)","1186195 62 
9 (HCl)",AOB1285,BCP08242,HY-13687A,HY13687A,H,2539}

> <pdid>
PD010532

> <targets>
{"IkB Kinase",IKK}

> <classes>
{}

> <pubchem_cids>
{56972179}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 O   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0897    3.7657    0.0000 N   0  0
  -10.3910    3.0180    0.0000 C   0  0
  -10.3936    1.5180    0.0000 O   0  0
  -11.6897    3.7702    0.0000 N   0  0
  -12.9910    3.0224    0.0000 C   0  0
  -12.9910    1.5223    0.0000 C   0  0
  -14.2901    0.7723    0.0000 C   0  0
  -15.5891    1.5223    0.0000 C   0  0
  -16.8882    0.7723    0.0000 F   0  0
  -15.5891    3.0223    0.0000 C   0  0
  -14.2901    3.7723    0.0000 C   0  0
  -14.2901    5.2723    0.0000 F   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 F   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
 25 26  1  0
 14 27  1  0
 27 28  1  0
 27 29  2  0
 29 11  1  0
  9 30  2  0
 30  5  1  0
 30 31  1  0
 31 32  2  0
 32  3  1  0
 32 33  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28297

> <plate>
Kinase v5-1

> <well>
K04

> <supplier_cmpd_name>
Ki 8751

> <ctcr_id>
4784

> <supplier_cmpd_id>
2542

> <smiles>
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC

> <pd_targets>
{KDR,FGFR2,KIT,PDGFRA,RORC}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,"Nuclear receptor","Protein Kinase","Nuclear hormone receptor subfamily 1","TK protein kinase group","Nuclear hormone receptor subfamily 1 group F","Tyrosine prot
ein kinase VEGFR family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Nuclear hormone receptors","Receptor kinases","1F. Retinoic acid-related orphans","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascul
ar endothelial growth factor) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polyme
rase II Transcription","Signaling by VEGF","Signaling by FGFR in disease","Signaling by KIT in disease","Signaling by PDGFR in disease","Generic Transcription Pathway","VEGFA-VEGFR2 Pathway","Signalin
g by FGFR2 in disease","Drug resistance of KIT mutants","Drug resistance of PDGFR mutants","Transcriptional regulation by RUNX3","VEGFR2 mediated cell proliferation","FGFR2 mutant receptor activation"
,"Dasatinib-resistant KIT mutants","Imatinib-resistant PDGFR mutants","RUNX3 Regulates Immune Response and Cell Migration","Activated point mutants of FGFR2"}

> <broad_targets>
{KDR}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{Ki8751,228559-41-9,228559419,"Ki 8751",Ki-8751,CHEMBL178455,C24H18F3N3O4,cc-604,cc604,MLS006011284,SCHEMBL1249562,CHEBI:92822,TERT-BUTYL2-BROMOBUTYRATE,TERTBUTYL2BROMOBUTYRATE,AOB6619,DTXSID60462145,
EX-A227,EXA227,HMS3269O17,HMS3413F19,HMS3654B19,HMS3677F19,BCP02842,ZINC1490414,ABP001020,BDB,T2446,S1363,2542,KI8751}

> <pdid>
PD003649

> <targets>
{"c-Kit | VEGFR-PDGFR",PDGFR,VEGFR,c-Kit}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{11317348}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 26  0  0  0  0            999 V2000
   11.4894   -2.2574    0.0000 H   0  3
    8.9894   -2.2574    0.0000 Cl  0  5
    6.4848   -8.2644    0.0000 C   0  0
    5.1873   -7.5117    0.0000 C   0  0
    5.1894   -6.0109    0.0000 N   0  0
    6.4889   -5.2601    0.0000 C   0  0
    6.4894   -3.7601    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2990   -5.2500    0.0000 Cl  0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 12  1  0
 26 20  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28298

> <plate>
Kinase v5-1

> <well>
K06

> <supplier_cmpd_name>
10-DEBC hydrochloride

> <ctcr_id>
3103

> <supplier_cmpd_id>
2558

> <smiles>
[H+].[Cl-].CCN(CC)CCCCN1c2ccccc2Oc3ccc(Cl)cc13

> <pd_targets>
{PIM1,KMT2A,MEN1}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,"Protein Kinase",Bromodomain,"CAMK protein kinase group","CAMK protein kinase PIM family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","PIM family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","FLT3 signaling in disease","Signaling by FLT3 ITD and TKD mutants","STAT5 activation downstream of FLT3 ITD
 mutants"}

> <broad_targets>
{PIM1}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{"0DEBC HYDROCHLORID","10-(4'-(N-Diethylamino)butyl)-2-chlorophenoxazine hydrochloride","10(4'(NDiethylamino)butyl)2chlorophenoxazine hydrochloride","10-DEBC HYDROCHLORIDE","10DEBC HYDROCHLORIDE","Akt
 Inhibitor X",925681-41-0,925681410,201788-90-1,201788901,"10-DEBC (hydrochloride)","10DEBC (hydrochloride)","Akt Inhibitor (10-NCP)","Akt Inhibitor (10NCP)",10-(4'-(n,10(4'(n,n-diethylamino)butyl)-2-
chlorophenoxa,ndiethylamino)butyl)2chlorophenoxa,"EMD 124020",2558,124020,"10-DEBC hydrochloride"}

> <pdid>
PD047288

> <targets>
{"Akt (Protein Kinase B)",PKB}

> <classes>
{}

> <pubchem_cids>
{74627774,16760284}

$$$$
UTKinase_V5
  SciTegic11012413002D

 19 20  0  0  0  0            999 V2000
    6.1718    0.7439    0.0000 N   0  0
    7.0537   -0.4695    0.0000 C   0  0
    8.5454   -0.3119    0.0000 O   0  0
    6.4430   -1.8405    0.0000 N   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.8054   -4.6666    0.0000 C   0  0
    6.2966   -4.8284    0.0000 N   0  0
    3.9200   -5.8774    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9  5  2  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
  7 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28299

> <plate>
Kinase v5-1

> <well>
K08

> <supplier_cmpd_name>
TPCA-1

> <ctcr_id>
6789

> <supplier_cmpd_id>
2559

> <smiles>
NC(=O)Nc1sc(cc1C(N)=O)c2ccc(F)cc2

> <pd_targets>
{IKBKB,JAK2,EIF2AK2,KMT2A,MEN1}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,"Protein Kinase",Bromodomain,"Other protein kinase group","TK protein kinase group","Other protein kinase IKK family","Tyrosine protein kinase JakA family"
,"Other protein kinase PEK family","Other protein kinase PKR"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","TK: Tyrosine kinase","IKK family","Non-receptor tyrosine kinases (nRTKs)","PEK family","Janus kinase (JakA) family","Other 
PEK family kinases"}

> <pathway_reactome>
{"Immune System","Cell Cycle",Disease,"Innate Immune System",Mitotic,"Infectious disease","Toll-like Receptor Cascades","Mitotic G1 phase and G1/S transition","Influenza Infection","Toll Like Receptor
 4 (TLR4) Cascade","G1 Phase","NS1 Mediated Effects on Host Pathways","MyD88-independent TLR4 cascade","Cyclin D associated events in G1","Inhibition of PKR","TRIF(TICAM1)-mediated TLR4 signaling","IK
K complex recruitment mediated by RIP1"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor"}

> <synonyms>
{PCA,TPCA-1,TPCA1,507475-17-4,507475174,5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide,5(4Fluorophenyl)2ureidothiophene3carboxamide,"IKK-2 Inhibitor IV","IKK2 Inhibitor IV",2-(carbamoylamino)-5-(4
-fluorophenyl)thiophene-3-carboxamide,2(carbamoylamino)5(4fluorophenyl)thiophene3carboxamide,(5-(p-Fluorophenyl)-2-ureido)thiophene-3-carboxamide,(5(pFluorophenyl)2ureido)thiophene3carboxamide,CHEMBL2
57167,MFCD,T3049,2559,"EMD 401481",S2824,401481}

> <pdid>
PD002651

> <targets>
{IKK}

> <classes>
{}

> <pubchem_cids>
{9903786}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 37  0  0  0  0            999 V2000
    2.4875    4.6307    0.0000 O   0  0
    1.0600    4.1700    0.0000 C   0  0
   -0.1700    5.0800    0.0000 N   0  0
   -1.4200    4.1700    0.0000 C   0  0
   -2.8476    4.6304    0.0000 O   0  0
   -0.9400    2.7100    0.0000 C   0  0
    0.5900    2.7000    0.0000 C   0  0
    1.3500    1.3600    0.0000 C   0  0
    2.8600    1.0300    0.0000 C   0  0
    4.1100    1.9400    0.0000 C   0  0
    5.5200    1.3100    0.0000 C   0  0
    5.6800   -0.2100    0.0000 C   0  0
    4.4200   -1.1200    0.0000 C   0  0
    3.0200   -0.4800    0.0000 C   0  0
    1.6000   -1.1100    0.0000 N   0  0
    1.0600   -2.5800    0.0000 C   0  0
    0.5600   -4.0500    0.0000 C   0  0
   -0.9400   -4.0500    0.0000 C   0  0
   -1.4100   -2.5800    0.0000 C   0  0
   -0.1700   -1.6900    0.0000 O   0  0
   -1.9800   -1.1000    0.0000 N   0  0
   -3.3900   -0.4700    0.0000 C   0  0
   -4.8000   -1.1000    0.0000 C   0  0
   -6.0500   -0.1900    0.0000 C   0  0
   -5.8800    1.3300    0.0000 C   0  0
   -4.4800    1.9600    0.0000 C   0  0
   -3.2300    1.0500    0.0000 C   0  0
   -1.7200    1.3700    0.0000 C   0  0
   -0.9500    0.0400    0.0000 C   0  0
    0.5600    0.0300    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 16  1  0
 19 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
 28  6  1  0
 28 29  2  0
 29 21  1  0
 29 30  1  0
 30  8  2  0
 30 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28300

> <plate>
Kinase v5-1

> <well>
K10

> <supplier_cmpd_name>
SB 218078

> <ctcr_id>
999

> <supplier_cmpd_id>
2560

> <smiles>
O=C1NC(=O)c2c1c3c4ccccc4n5C6CCC(O6)n7c8ccccc8c2c7c35

> <pd_targets>
{CDK2,CDK4,CHEK1,CCND1,KMT2A,MEN1,CCNE1,CCNE2,CDK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","Epigenetic regulator",Reader,Bromodomain,"CAMK protein kinase group",
"CAMK protein kinase CAMK1 family","CAMK protein kinase CHK1 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","CDK4 subfamily","CAMK: Calcium/calmodulin-dependent protein kin
ases","CAMK-like (CAMKL) family","CHK1 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","Transcriptional Regulation by TP53","G
1 Phase","Regulation of TP53 Activity","Cyclin D associated events in G1","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation","DNA Repair","DNA Double-Strand Break Repair"
,"Homology Directed Repair","Regulation of mitotic cell cycle","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","APC/C-mediated degradation of cell cycle proteins","HDR th
rough Homologous Recombination (HRR)","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Homologous DNA Pairing and Strand Exchange","APC/C:Cdc20 mediated degradation of m
itotic proteins","Presynaptic phase of homologous DNA pairing and strand exchange","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phos
pho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{CHEK1}

> <broad_moa>
{"CHK inhibitor"}

> <synonyms>
{"SB 218078",135897-06-2,135897062,SB-218078,SB218078,HSCI1_000147,HSCI1000147,HSCI1-000147,"HSCI1 000147",UNII-S6U3J3UP11,UNIIS6U3J3UP11,BDBM6763,CHEMBL304428,GTPL6037,S6U3J3UP11,SCHEMBL9224945,CHEBI
:91500,DTXSID10392024,HMS3229O08,HMS3269B11,HMS3413H07,HMS3677H07,BCP25033,EX-A4201,EXA4201,AKOS024457167,CCG-206880,CCG206880,"EMD 559402",2560,559402}

> <pdid>
PD004216

> <targets>
{"Checkpoint Kinases",Chk1,CHK1}

> <classes>
{}

> <pubchem_cids>
{3387354}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    8.5623   -9.6094    0.0000 C   0  0
    7.0623   -9.6116    0.0000 O   0  0
    6.3091   -8.3134    0.0000 C   0  0
    7.0591   -7.0143    0.0000 C   0  0
    6.3090   -5.7153    0.0000 C   0  0
    4.8090   -5.7153    0.0000 C   0  0
    4.0591   -7.0144    0.0000 C   0  0
    4.8091   -8.3134    0.0000 C   0  0
    4.0561   -9.6117    0.0000 O   0  0
    2.5561   -9.6096    0.0000 C   0  0
    4.0559   -4.4171    0.0000 C   0  0
    4.8036   -3.1167    0.0000 O   0  0
    2.5551   -4.4192    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 N   0  0
   -0.2237   -5.5078    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
  6 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  2  0
 21 22  1  0
 22 14  2  0
 22 23  1  0
 23 24  1  0
 23 25  2  0
M  END
> <name>
UTKinase_V5

> <id>
28301

> <plate>
Kinase v5-1

> <well>
K12

> <supplier_cmpd_name>
TCS 359

> <ctcr_id>
5064

> <supplier_cmpd_id>
2591

> <smiles>
COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O

> <pd_targets>
{FLT3,KMT2A,MEN1,RECQL}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,"Protein Kinase",Bromodomain,"TK protein kinase group","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by Insulin receptor","Insulin receptor signalling cascade","IRS-mediated signalling","PI3K Cascade"}

> <broad_targets>
{FLT3}

> <broad_moa>
{"FLT3 inhibitor"}

> <synonyms>
{"TCS 359",301305-73-7,301305737,"301305 73 7","Flt-3 inhibitor","Flt3 inhibitor","Flt 3 inhibitor",TCS-359,TCS359,CHEMBL210833,MFCD00617269,"2-((3,4-Dimethoxybenzoyl)amino)-4,5,6,7-benzo(b)thiophene-
3-carboxamide","2((3,4Dimethoxybenzoyl)amino)4,5,6,7benzo(b)thiophene3carboxamide",2((3,4Dimethoxybenzoyl)amino)4,"EMD 343020",2591,343020}

> <pdid>
PD010262

> <targets>
{FLT3}

> <classes>
{}

> <pubchem_cids>
{1048845}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    2.6015   -1.5060    0.0000 C   0  0
    2.5973   -3.0060    0.0000 C   0  0
    3.8942   -3.7597    0.0000 C   0  0
    3.8899   -5.2597    0.0000 C   0  0
    5.1868   -6.0134    0.0000 I   0  0
    2.5887   -6.0060    0.0000 C   0  0
    1.2918   -5.2523    0.0000 C   0  0
    1.2961   -3.7523    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0128   -6.0039    0.0000 F   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -2.6160   -7.4949    0.0000 F   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2089   -5.9859    0.0000 F   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -2.5984   -1.4941    0.0000 C   0  0
   -1.2981   -0.7463    0.0000 O   0  0
   -3.8966   -0.7411    0.0000 N   0  0
   -3.8946    0.7597    0.0000 O   0  0
   -5.1928    1.5127    0.0000 C   0  0
   -5.1908    3.0135    0.0000 C   0  0
   -5.9366    4.2238    0.0000 C   0  0
   -4.4366    4.2186    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18 10  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28302

> <plate>
Kinase v5-1

> <well>
K14

> <supplier_cmpd_name>
PD 198306

> <ctcr_id>
3170

> <supplier_cmpd_id>
2605

> <smiles>
Cc1cc(I)ccc1Nc2c(F)c(F)c(F)cc2C(=O)NOCC3CC3

> <pd_targets>
{RORC,KMT2A,MEN1}

> <pathway_gtopdb>
{"Transcription factor","Epigenetic regulator","Nuclear receptor",Reader,"Nuclear hormone receptor subfamily 1",Bromodomain,"Nuclear hormone receptor subfamily 1 group F","Nuclear hormone receptor sub
family 1 group F member 3"}

> <pathway_chembl>
{Receptors,"Nuclear hormone receptors","1F. Retinoic acid-related orphans"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional regulation by RUNX3","RUNX3 Regulates Immune Response and Cell Migration"}

> <broad_targets>
{MAP2K1,MAP2K2}

> <broad_moa>
{"MAP kinase inhibitor","MEK inhibitor"}

> <synonyms>
{HMS3413J17,HMS3677J17,ZINC3964489,"PD 198306",212631-61-3,212631613,PD-198306,PD198306,UNII-WQ5121ZGT3,UNIIWQ5121ZGT3,WQ5121ZGT3,SCHEMBL1801637,CHEMBL1474985,CHEBI:93541,DTXSID70433306,HMS3229H15,HMS
3269F09,AKOS024457191,NCGC00167793-01,NCGC0016779301,NCGC00167793-02,NCGC0016779302,B7124,J-013958,J013958,BRD-K88677950-,BRDK88677950,2605,"EMD 444965",444965}

> <pdid>
PD015686

> <targets>
{MEK1/2,MEK,"MEK1/2 Inhibitor II"}

> <classes>
{}

> <pubchem_cids>
{9956637}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    2.5532   -4.4223    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -3.8916    3.7585    0.0000 C   0  0
   -3.8864    5.2585    0.0000 C   0  0
   -2.5847    6.0040    0.0000 C   0  0
   -2.5796    7.5040    0.0000 C   0  0
   -1.2883    5.2495    0.0000 C   0  0
   -1.2935    3.7495    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 10  1  0
  8 17  1  0
 17 18  2  0
 17 19  1  0
 19  4  2  0
 19 20  1  0
 20  2  2  0
M  END
> <name>
UTKinase_V5

> <id>
28303

> <plate>
Kinase v5-1

> <well>
K16

> <supplier_cmpd_name>
Ryuvidine

> <ctcr_id>
5954

> <supplier_cmpd_id>
2609

> <smiles>
Cc1sc2C(=O)C=C(Nc3ccc(C)cc3)C(=O)c2n1

> <pd_targets>
{RORC,BLM,CCND1,CDK4,CDK2,THRB,KMT2A,MEN1,KMT5A}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator","Nuclear receptor",Kinase,Reader,Writer,"Nuclear hormone receptor subfamily 1","Protein Kinase",Bromodomain,"Protein methyltransferase","Nuclear h
ormone receptor subfamily 1 group F","CMGC protein kinase group","Nuclear hormone receptor subfamily 1 group A","SET domain","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinas
e CDK family","Nuclear hormone receptor subfamily 1 group A member 2","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","1F. Retinoic acid-related orphans","CMGC: Containing CDK",MAPK,GSK3,"CLK families","1A. Thyroid hor
mone receptors","2.1.1.43 Histone methyltransferases (HMTs)","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","CDK4 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","DNA Repair","Cell Cycle","Metabolism of proteins","RNA Polymerase II Transcription","DNA Double-Strand Break Repair",Mitotic,"Post-translational protein modificatio
n","Generic Transcription Pathway","Homology Directed Repair","Mitotic G1 phase and G1/S transition",SUMOylation,"Transcriptional regulation by RUNX3","HDR through Homologous Recombination (HRR) or Si
ngle Strand Annealing (SSA)","Transcriptional Regulation by TP53","G1 Phase","SUMO E3 ligases SUMOylate target proteins","RUNX3 Regulates Immune Response and Cell Migration","HDR through Homologous Re
combination (HRR)","Regulation of TP53 Activity","Cyclin D associated events in G1","SUMOylation of intracellular receptors","Homologous DNA Pairing and Strand Exchange","Regulation of TP53 Expression
 and Degradation","Regulation of TP53 Activity through Methylation","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation"}

> <broad_targets>
{CDK2,CDK4}

> <broad_moa>
{"histone lysine methyltransferase inhibitor"}

> <synonyms>
{Ryuvidine,"Cdk4 Inhibitor III",265312-55-8,265312558,"265312 55 8","2-Methyl-5-((4-methylphenyl)amino)benzothiazole-4,7-dione","2Methyl5((4methylphenyl)amino)benzothiazole4,7dione","2 Methyl 5 ((4 me
thylphenyl)amino)benzothiazole 4,7 dione",CHEM,"EMD 219478",2609,219478}

> <pdid>
PD017062

> <targets>
{"Lysine Methyltransferases",cdk}

> <classes>
{}

> <pubchem_cids>
{481747}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
    1.2947   -3.7531    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 N   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6060   -6.0003    0.0000 C   0  0
   -2.6060   -7.5003    0.0000 C   0  0
   -1.3070   -8.2503    0.0000 C   0  0
   -0.0080   -7.5003    0.0000 C   0  0
   -0.0079   -6.0003    0.0000 C   0  0
    1.2918   -8.2508    0.0000 C   0  0
    1.2927   -9.7508    0.0000 F   0  0
    2.5906   -7.5004    0.0000 F   0  0
    2.5911   -9.0002    0.0000 F   0  0
   -3.9058   -8.2507    0.0000 C   0  0
   -5.2053   -7.5015    0.0000 F   0  0
   -3.9054   -9.7507    0.0000 F   0  0
   -5.2045   -9.0013    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 16 18  1  0
 18 19  1  0
 18 20  1  0
 18 21  1  0
 14 22  1  0
 22 23  1  0
 22 24  1  0
 22 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28304

> <plate>
Kinase v5-1

> <well>
K18

> <supplier_cmpd_name>
IMD 0354

> <ctcr_id>
1228

> <supplier_cmpd_id>
2611

> <smiles>
Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F

> <pd_targets>
{TMPRSS4,RORC,KMT2A,MEN1,FLT3,KDR,IKBKB}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator",Protease,"Nuclear receptor",Reader,Kinase,"Serine protease","Nuclear hormone receptor subfamily 1",Bromodomain,"Protein Kinase","Nuclear hormone r
eceptor subfamily 1 group F","TK protein kinase group","Other protein kinase group","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase PDGFR family","Tyrosine protein kin
ase VEGFR family","Other protein kinase IKK family"}

> <pathway_chembl>
{Receptors,"Nuclear hormone receptors","Catalytic receptors","1F. Retinoic acid-related orphans","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kinases (RTKs)","IK
K family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Immune System","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Generic Transcription Pathwa
y","Signaling by Insulin receptor","Signaling by VEGF","Toll-like Receptor Cascades","Transcriptional regulation by RUNX3","Insulin receptor signalling cascade","VEGFA-VEGFR2 Pathway","Toll Like Recep
tor 4 (TLR4) Cascade","RUNX3 Regulates Immune Response and Cell Migration","IRS-mediated signalling","VEGFR2 mediated cell proliferation","MyD88-independent TLR4 cascade","PI3K Cascade","TRIF(TICAM1)-
mediated TLR4 signaling","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor","NFkB pathway inhibitor"}

> <synonyms>
{IMD-0354,IMD0354,978-62-1,978621,"IMD 0354","IKK-2 Inhibitor V","IKK2 Inhibitor V","N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide","N(3,5bis(trifluoromethyl)phenyl)5chloro2hydroxyben
zamide",TCMDC-125465,TCMDC125465,UNII-76145IS906,UNII76145IS906,CHEMBL536151,"N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide","N(3,5Bistrifluoromethylphenyl)5chloro2hydroxybenzamide",MF
CD00218820,761,T6141,2611,"EMD 401482",S2864,401482}

> <pdid>
PD010541

> <targets>
{IKK,"IKK-2 Inhibitor V"}

> <classes>
{}

> <pubchem_cids>
{5081913}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 37  0  0  0  0            999 V2000
    2.6030   -2.9977    0.0000 O   0  5
    2.6003   -1.4977    0.0000 N   0  3
    3.8983   -0.7459    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -2.6017    2.9971    0.0000 S   0  0
   -1.3070    5.2502    0.0000 N   0  0
   -2.6078    5.9988    0.0000 C   0  0
   -2.6109    7.4996    0.0000 N   0  0
   -3.9118    8.2481    0.0000 C   0  0
   -5.2095    7.4959    0.0000 O   0  0
   -3.9149    9.7490    0.0000 C   0  0
   -5.2157   10.4975    0.0000 C   0  0
   -5.2210   11.9975    0.0000 C   0  0
   -6.5226   12.7430    0.0000 C   0  0
   -7.8190   11.9885    0.0000 C   0  0
   -7.8138   10.4885    0.0000 C   0  0
   -6.5122    9.7430    0.0000 C   0  0
   -2.6165   10.5016    0.0000 C   0  0
   -2.6170   12.0017    0.0000 C   0  0
   -1.3182   12.7522    0.0000 C   0  0
   -0.0189   12.0027    0.0000 C   0  0
   -0.0183   10.5027    0.0000 C   0  0
   -1.3171    9.7522    0.0000 C   0  0
   -3.9078    5.2487    0.0000 C   0  0
   -5.2071    5.9983    0.0000 Cl  0  0
   -5.2068    4.4985    0.0000 Cl  0  0
   -3.9078    3.7487    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 15 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 11 28  1  0
 28 29  1  0
 28 30  1  0
 28 31  1  0
  6 32  2  0
 32 33  1  0
 33 34  2  0
 34  4  1  0
 34 35  1  0
M  CHG  2   1  -1   2   1
M  END
> <name>
UTKinase_V5

> <id>
28305

> <plate>
Kinase v5-1

> <well>
K20

> <supplier_cmpd_name>
CGK 733

> <ctcr_id>
6787

> <supplier_cmpd_id>
2639

> <smiles>
[O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c3ccccc3)C(Cl)(Cl)Cl)ccc1F

> <pd_targets>
{ATM,KMT2A,MEN1,RORC,ATR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Transcription factor",Kinase,Reader,"Nuclear receptor","Protein Kinase",Bromodomain,"Nuclear hormone receptor subfamily 1","Atypical protein kinase group","Nuclear horm
one receptor subfamily 1 group F","Atypical protein kinase PIKK family","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Nuclear hormone receptors",Atypical,"1F. Retinoic acid-related orphans","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Other PIKK family ki
nases","ATR subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)","DNA Repair","Cell Cycle Checkpoints","RNA Polymerase II Transcription","DNA Double-Strand Break Repair","G1/S DNA Damage Checkpoints","Generic Transcri
ption Pathway","Homology Directed Repair","p53-Dependent G1/S DNA damage checkpoint","Transcriptional regulation by RUNX3","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)"
,"p53-Dependent G1 DNA Damage Response","RUNX3 Regulates Immune Response and Cell Migration","HDR through Homologous Recombination (HRR)","Stabilization of p53","Homologous DNA Pairing and Strand Exch
ange","Autodegradation of the E3 ubiquitin ligase COP1","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{ATM,ATR}

> <broad_moa>
{"ATM kinase inhibitor","ATR kinase inhibitor"}

> <synonyms>
{CGK733,905973-89-9,905973899,"CGK 733",CGK-733,"ATM/ATR Kinase Inhibitor","Diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea",CHEMBL1221601,UNII-L3DGZ99QYM,UNIIL3DGZ99QYM,L3DGZ99QYM,EC-000.
1970,EC000.1970,GTPL5929,SCHEMBL1980806,CHEBI:91739,AOB6206,DTXSID30424997,EX-A177,EXA177,T1821,"EMD 118501",2639,118501}

> <pdid>
PD010604

> <targets>
{"Other Apoptosis",ATR/ATM}

> <classes>
{}

> <pubchem_cids>
{6605258}

$$$$
UTKinase_V5
  SciTegic11012413002D

 43 48  0  0  1  0            999 V2000
    2.4192   -8.3243    0.0000 C   0  0
    1.2028   -7.4466    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 C   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -3.9027    5.2517    0.0000 C   0  0
   -2.6052    6.0043    0.0000 Cl  0  0
   -5.2032    5.9990    0.0000 C   0  0
   -6.5007    5.2464    0.0000 C   0  0
   -6.4977    3.7464    0.0000 C   0  0
   -5.1971    2.9990    0.0000 C   0  0
   -5.1941    1.4990    0.0000 Cl  0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6079   -6.7003    0.0000 C   0  0
   -0.2222   -7.9149    0.0000 C   0  0
   -0.6776   -9.3422    0.0000 C   0  0
   -2.1432   -9.6615    0.0000 O   0  0
    0.3320  -10.4528    0.0000 N   0  0
    1.8079  -10.2697    0.0000 C   0  0
    2.4273  -11.6359    0.0000 C   0  0
    1.3194  -12.6471    0.0000 C   0  0
    0.0153  -11.9060    0.0000 C   0  0  2  0  0  0
   -1.3526  -12.5170    0.0000 C   0  0
   -1.5087  -14.0096    0.0000 N   0  0
   -2.8035  -14.7413    0.0000 C   0  0
   -2.4879  -16.2077    0.0000 C   0  0
   -0.9957  -16.3606    0.0000 C   0  0
   -0.3891  -14.9887    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
 13 16  1  0
 16 17  2  0
 16 18  2  0
 16 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 20  1  0
 26 27  1  0
  4 28  2  0
 28 29  1  0
 28 30  1  0
 30  2  2  0
 30 31  1  0
 31 32  2  0
 31 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 33  1  0
 37 38  1  6
 38 39  1  0
 39 40  1  0
 40 41  1  0
 41 42  1  0
 42 43  1  0
 43 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28306

> <plate>
Kinase v5-1

> <well>
K22

> <supplier_cmpd_name>
PHA 665752

> <ctcr_id>
7089

> <supplier_cmpd_id>
2693

> <smiles>
Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)[S](=O)(=O)Cc4c(Cl)cccc4Cl)c(C)c1C(=O)N5CCC[C@@H]5CN6CCCC6

> <pd_targets>
{CLK3,HIPK2,NUAK2,DCLK3,MAP2K5,MET,SRC,CLK1,NTRK3,CDK4,DDR1,PAK1,TYK2,CAMK1,CASK,PRPF4B,FLT3,MST1R,KDR,ABL1,KIT,STK10,CDK16,CAMKK2,CDK14,INSRR,BMP2K,PAK5,HIPK1,GAK,YES1,RPS6KA6,MYLK,CDK15,MAP4K4,EIF2A
K4,BMPR2,CDK7,PDGFRB,GRK1,MAP4K3,RIPK1,RPS6KA3,DCLK1,ROCK2,NTRK1,MAP4K1,PIP5K1A,CSNK2A2,JAK1,NEK2,PIP4K2B,FGFR1,FGFR3,INSR,AURKC,DDR2,STK3,MAP4K5,HUNK,SLK,RET,NIM1K,CAMK2G,MAK,PRKAA2,TBK1,NUAK1,TNIK,M
AP3K19,CAMKK1,MYLK2,CSNK1D,GRK7,HIPK4,MAP3K7,CAMK2A,PTK2B,CSNK1E,MAP3K3,CDK18,ULK1,STK17B,ABL2,PHKG2,MAPK7,MAP2K1,RIOK3,CDKL2,RPS6KA5,CSF1R,NTRK2,PHKG1,PLK2,CILK1,TAOK3,TAOK1,MAP2K2,AURKB,JAK3,TEK,CDK
9,AXL,BLK,PAK3,ROS1,ALK,EPHB6,STK17A,MAP3K4,PDGFRA,IRAK3,IKBKE,SRPK3,ULK2,IRAK4,EPHA8,RIOK1,TSSK1B,SRPK2,STK16,STK11,TYRO3,MAP3K2,PLK4,MARK2,FGFR2,STK33,PTK2,MINK1,DCLK2,IRAK1,FLT4,RPS6KB1,CLK2,MAP3K1
3,JAK2,FGR,SRPK1,MAP4K2,EGFR,MERTK,CAMK2D,PRKAA1,CDK17,LCK,TIE1,HIPK3,MAP3K12,AAK1,SIK2,TAOK2,STK26,CAMK1D,GRK4}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","CMGC protein kinase group","CAMK protein kinase group","STE protein kinase group","TK protein kinase group","Other protein kinase group","AGC pr
otein kinase group","TKL protein kinase group","CK1 protein kinase group","Atypical protein kinase group","CMGC protein kinase CLK family","CMGC protein kinase DYRK family","CAMK protein kinase CAMK1 
family","CAMK protein kinase DCAMK1 family","STE protein kinase STE7 family","Tyrosine protein kinase Met family","Tyrosine protein kinase Src family","Tyrosine protein kinase Trk family","Tyrosine pr
otein kinase DDR family","STE protein kinase STE20 family","Tyrosine protein kinase JakA family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase 
Abl family","CMGC protein kinase CDK family","Other protein kinase CAMKK family","Tyrosine protein kinase InsR family","Other protein kinase NAK family","AGC protein kinase RSK family","CAMK protein k
inase MLCK family","Other protein kinase PEK family","TKL protein kinase STKR family","AGC protein kinase GRK family","TKL protein kinase RIPK family","AGC protein kinase DMPK family","Other protein k
inase CK2 family","Other protein kinase NEK family","Tyrosine protein kinase FGFR family","Other protein kinase AUR family","Tyrosine protein kinase Ret family","CAMK protein kinase CAMK2 family","CMG
C protein kinase RCK family","Other protein kinase IKK family","STE protein kinase STE11 family","CK1 protein kinase CK1 family","TKL protein kinase MLK family","Tyrosine protein kinase Fak family","O
ther protein kinase ULK family","CAMK protein kinase DAPK family","CAMK protein kinase PHk family","CMGC protein kinase MAPK family","Atypical protein kinase RIO family","CMGC protein kinase CDKL fami
ly","Other protein kinase PLK family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Sev family","TKL protein kinase IRAK family","CMGC protein kina
se SRPK family","Tyrosine protein kinase Eph family","CAMK protein kinase TSSK family","CAMK protein kinase unique family","Tyrosine protein kinase EGFR family","CMGC protein kinase HIPK subfamily","C
AMK protein kinase NuaK subfamily","STE protein kinase PAKA subfamily","STE protein kinase SLK subfamily","CMGC protein kinase TAIRE subfamily","Other protein kinase Meta subfamily","CMGC protein kina
se PFTAIRE","STE protein kinase PAKB subfamily","AGC protein kinase RSK subfamily","STE protein kinase MSN subfamily","Other protein kinase GCN2 subfamily","TKL protein kinase STKR Type 2 subfamily","
CMGC protein kinase CDK7 subfamily","AGC protein kinase GRK subfamily","STE protein kinase KHS subfamily","AGC protein kinase ROCK subfamily","STE protein kinase MST subfamily","CAMK protein kinase NI
M1 subfamily","CMGC protein kinase MAK","CAMK protein kinase AMPK subfamily","TKL protein kinase TAK1 subfamily","STE protein kinase MEKK2","CMGC protein kinase PCTAIRE","CMGC protein kinase ERK5","At
ypical protein kinase RIO3 subfamily","AGC protein kinase MSK subfamily","Other protein kinase PLK2","STE protein kinase TAO subfamily","CMGC protein kinase CDK9 subfamily","TKL protein kinase STKR Ty
pe 1 subfamily","Atypical protein kinase RIO1 subfamily","CAMK protein kinase LKB subfamily","CAMK protein kinase MARK subfamily","AGC protein kinase p70 subfamily","TKL protein kinase LZK subfamily",
"CAMK protein kinase QIK subfamily","STE protein kinase YSK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7",
"Sterile 11","Sterile 20 kinases","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","Lipid modifying kinases","CK1: Casein kinase 1",Atypical,"CLK family","Dual-specificity tyrosine-(Y)-phos
phorylation regulated kinase (DYRK) family","CAMK-like (CAMKL) family","DCAMKL family","STE7 family","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","STE20 family","CAMK1 family","CASK fa
mily","Other protein kinases","RSK family","Myosin Light Chain Kinase (MLCK) family","TKL: Tyrosine kinase-like","G protein-coupled receptor kinases (GRKs)","DMPK family","Type I PIP kinases (1-phosph
atidylinositol-4-phosphate 5-kinase family)","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","CAMK2 family","RCK family","Casein kinase 1 (CK1) family","STE11 family","Death
-associated kinase (DAPK) family","Phosphorylase kinase (PHK) family","Mitogen-activated protein kinases (MAP kinases)","RIO family","Cyclin-dependent kinase-like (CDKL) family","SRPK family","Testis 
specific kinase (TSSK) family","CAMK-unique family","HIPK subfamily","NuaK subfamily","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","CDK4 subfamily","PAKA subfamily","PRP4
 subfamily","SLK subfamily","TAIRE subfamily","CAMKK family","Numb-associated kinase (NAK) family","PAKB subfamily","RSK subfamily","MSN subfamily","PEK family","Receptor serine/threonine kinase (RSTK
) family","CDK7 subfamily","Opsin/rhodopsin kinases","KHS subfamily","Receptor interacting protein kinase (RIPK) family","Rho kinase","Casein kinase 2 (CK2) family","NIMA (never in mitosis gene a)- re
lated kinase (NEK) family","Aurora kinase (Aur) family","MST subfamily","HUNK subfamily","NIM1 subfamily","AMPK subfamily","IKK family","STE20 subfamily","Mixed Lineage Kinase (MLK) family","Unc-51-li
ke kinase (ULK) family","ERK subfamily","RIO3 subfamily","MSK subfamily","Polo-like kinase (PLK) family","TAO subfamily","CDK9 subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","RIO1
 subfamily","NAK family","LKB subfamily","MARK subfamily","p70 subfamily","QIK subfamily","YSK subfamily","GRK4 subfamily","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Src family","T
ype VII RTKs: Neurotrophin receptor/Trk family","Type XVI RTKs: DDR (collagen receptor) family","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF 
(vascular endothelial growth factor) receptor family","Abl family","Meta subfamily","Type II RTKs: Insulin receptor family","GCN2 subfamily","Type II receptor serine/threonine kinases","Type V RTKs: F
GF (fibroblast growth factor) receptor family","Type XIV RTKs: RET","TAK1 subfamily","Fak family","Type XII RTKs: TIE family of angiopoietin receptors","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) re
ceptor family","Type XVII RTKs: ROS receptors","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XIII RTKs: Ephrin receptor family","LZK subfamily","Type I RTKs: ErbB (epidermal g
rowth factor) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Developmental Biology","Cell Cycle","Extracellular matrix organization","Immune System","Neuronal System",Disease,"Vesicle-mediated transport"
,"Cellular responses to external stimuli",Metabolism,Autophagy,"Metabolism of RNA",Hemostasis,"Programmed Cell Death","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Nervou
s system development",Mitotic,"Non-integrin membrane-ECM interactions","Cytokine Signaling in Immune system","Transmission across Chemical Synapses","Infectious disease","Diseases of signal transducti
on by growth factor receptors and second messengers","Innate Immune System","Membrane Trafficking","Signaling by Rho GTPases","Cellular responses to stress","Signaling by TGFB family members","Intrace
llular signaling by second messengers","Signaling by GPCR","Metabolism of lipids","Signaling by Hippo",Macroautophagy,"Metabolism of carbohydrates","rRNA processing","MAPK family signaling cascades","
MTOR signalling","Cell surface interactions at the vascular wall",Apoptosis,"Generic Transcription Pathway","Signaling by NTRKs","Axon guidance","Mitotic G1 phase and G1/S transition","Interferon Sign
aling","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by Insulin receptor","Signaling by MST1","Signaling by VEGF","Leishmania infection","Signaling by KIT in disease","N
eutrophil degranulation","trans-Golgi Network Vesicle Budding","RHO GTPase Effectors","Cellular Senescence","Response of EIF2AK4 (GCN2) to amino acid deficiency","Signaling by BMP","HIV Infection","PI
P3 activates AKT signaling","GPCR downstream signalling","Toll-like Receptor Cascades","Phospholipid metabolism","Regulation of mitotic cell cycle","Signaling by FGFR in disease","Mitotic G2-G2/M phas
es","Signaling by Interleukins","Selective autophagy","Glycogen metabolism","rRNA processing in the nucleus and cytosol","M Phase","MAPK1/MAPK3 signaling","Signaling by PDGFR in disease","mTORC1-media
ted signalling","Clathrin-mediated endocytosis","Apoptotic execution phase","Transcriptional Regulation by TP53","Signaling by NTRK1 (TRKA)","Semaphorin interactions","Signaling by NTRK3 (TRKC)","G1 P
hase","EPH-Ephrin signaling","Interferon alpha/beta signaling","Activation of NMDA receptors and postsynaptic events","Insulin receptor signalling cascade","VEGFA-VEGFR2 Pathway","Parasite infection",
"Drug resistance of KIT mutants","Signaling by ROBO receptors","Golgi Associated Vesicle Biogenesis","Leishmania parasite growth and survival","RHO GTPases activate PAKs","Oxidative Stress Induced Sen
escence","HIV Life Cycle","Negative regulation of the PI3K/AKT network","G alpha (i) signalling events","Toll Like Receptor 4 (TLR4) Cascade","Toll Like Receptor 5 (TLR5) Cascade","PI Metabolism","Ant
iviral mechanism by IFN-stimulated genes","APC/C-mediated degradation of cell cycle proteins","Signaling by FGFR1 in disease","Signaling by FGFR3 in disease","RET signaling","G2/M Transition","Interle
ukin-2 family signaling","Interleukin-1 family signaling",Mitophagy,"Glycogen breakdown (glycogenolysis)","Major pathway of rRNA processing in the nucleolus and cytosol","Transcriptional Regulation by
 VENTX","Mitotic Metaphase and Anaphase","RAF/MAP kinase cascade","Transcriptional regulation by RUNX1","Drug resistance of PDGFR mutants","Toll Like Receptor 2 (TLR2) Cascade","Signaling by FGFR2 in 
disease","VEGF ligand-receptor interactions","G alpha (q) signalling events","Host Interactions of HIV factors","Cargo recognition for clathrin-mediated endocytosis","Apoptotic cleavage of cellular pr
oteins","Regulation of TP53 Activity","Signalling to ERK5","Sema4D in semaphorin signaling","Signalling to ERKs","Activated NTRK3 signals through PI3K","Cyclin D associated events in G1","EPHB-mediate
d forward signaling","Regulation of IFNA signaling","Post NMDA receptor activation events","Assembly and cell surface presentation of NMDA receptors","IRS-mediated signalling","VEGFR2 mediated cell pr
oliferation","Leishmania phagocytosis","Dasatinib-resistant KIT mutants","Activation of RAC1","Anti-inflammatory response favouring Leishmania parasite infection","Late Phase of HIV Life Cycle",PI5P,"
PP2A and IER3 Regulate PI3K/AKT Signaling","Visual phototransduction","MyD88-independent TLR4 cascade","MyD88 cascade initiated on plasma membrane","Synthesis of PIPs at the plasma membrane","ISG15 an
tiviral mechanism","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","FGFR1 mutant receptor activation","Signaling by FGFR3 point mutants in cancer","Centrosome maturation
","Interleukin-2 signaling","Interleukin-1 signaling","Receptor Mediated Mitophagy","Role of ABL in ROBO-SLIT signaling","Activation of TRKA receptors","Mitotic Anaphase","Interleukin-15 signaling","R
UNX1 regulates transcription of genes involved in BCR signaling","Ephrin signaling","Imatinib-resistant PDGFR mutants","Toll Like Receptor TLR6:TLR2 Cascade","EPHA-mediated growth cone collapse","FGFR
2 mutant receptor activation","VEGF binds to VEGFR leading to receptor dimerization","Gastrin-CREB signalling pathway via PKC and MAPK","The role of Nef in HIV-1 replication and disease pathogenesis",
"Regulation of TP53 Activity through Phosphorylation","Sema4D mediated inhibition of cell attachment and migration","Signalling to RAS","Activation of RAC1 downstream of NMDARs","PI3K Cascade","FCGR3A
-mediated phagocytosis","Activation of AMPK downstream of NMDARs","FCGR3A-mediated IL10 synthesis","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Transcription of 
the HIV genome","The phototransduction cascade","TRIF(TICAM1)-mediated TLR4 signaling","MAP kinase activation","Sema4D induced cell migration and growth-cone collapse","Prolonged ERK activation events
","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Acetylation","Signaling by activated point mutants of FGFR1","FGFR3 mutant receptor activation","Loss of p
roteins required for interphase microtubule organization from the centrosome","NGF-independant TRKA activation","CD163 mediating an anti-inflammatory response","Separation of Sister Chromatids","MyD88
:MAL(TIRAP) cascade initiated on plasma membrane","Activated point mutants of FGFR2","EGFR Transactivation by Gastrin","Nef-mediates down modulation of cell surface receptors by recruiting them to cla
thrin adapters","p38MAPK events","RSK activation","HIV Transcription Elongation",Inactivation,"recovery and regulation of the phototransduction cascade","IKK complex recruitment mediated by RIP1","MAP
K targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","PI5P Regulates 
TP53 Acetylation","Signaling by activated point mutants of FGFR3","Ras activation upon Ca2+ influx through NMDA receptor","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Loss of Nlp from mitot
ic centrosomes","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Frs2-mediated activation","activated TAK1 mediates p38 MAPK activation","Nef Mediated CD4 Down-regulation","Tat-mediated
 elongation of the HIV-1 transcript","CREB phosphorylation","APC-Cdc20 mediated degradation of Nek2A","ERK/MAPK targets","Formation of HIV-1 elongation complex containing HIV-1 Tat","ERKs are inactiva
ted"}

> <broad_targets>
{MET}

> <broad_moa>
{"c-Met inhibitor"}

> <synonyms>
{HA66575,PHA-665752,PHA665752,477575-56-7,477575567,"PHA 665752",TCMDC-125885,TCMDC125885,UNII-0VXU5T5R3J,UNII0VXU5T5R3J,"PHA-665752 hydrate","PHA665752 hydrate",0VXU5T5R3J,CHEMBL450786,CHEBI:90197,cc
-47,cc47,SCHEMBL93654,C32H34Cl2N4O4S,GTPL5700,DTXSID30197270,EX-A019,EXA019,BCPP000112,HMS3269N19,HMS3413B20,HMS3677B20,AM,T6128,2693,S1070}

> <pdid>
PD013025

> <targets>
{c-Met}

> <classes>
{}

> <pubchem_cids>
{10461815}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 29  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 C   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -7.1998   -1.6833    0.0000 C   0  0
   -8.0836   -0.4712    0.0000 C   0  0
   -9.5751   -0.6304    0.0000 C   0  0
  -10.1830   -2.0016    0.0000 C   0  0
   -9.2994   -3.2138    0.0000 C   0  0
   -7.8079   -3.0546    0.0000 C   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -5.1376   -4.2063    0.0000 C   0  0
   -6.5079   -4.8163    0.0000 O   0  0
   -3.8385   -4.9563    0.0000 N   0  0
   -2.7238   -3.9526    0.0000 C   0  0
   -1.2566   -4.2643    0.0000 O   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
  9 16  2  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 16  1  0
 22 23  2  0
 23  7  1  0
 23 24  1  0
 24  5  1  0
 24 25  2  0
 25  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28307

> <plate>
Kinase v5-1

> <well>
M04

> <supplier_cmpd_name>
PD 407824

> <ctcr_id>
3182

> <supplier_cmpd_id>
2694

> <smiles>
Oc1ccc2[nH]c3cc(c4ccccc4)c5C(=O)NC(=O)c5c3c2c1

> <pd_targets>
{CHEK1,WEE1,CDK4,FTL,RORC,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,KMT2A,MEN1,FFP,ALD}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Transcription factor","Epigenetic regulator",Kinase,"Nuclear receptor",Reader,Transferase,"Protein Kinase","Nuclear hormone receptor subfamily 1",Bromodomain,"CAMK prot
ein kinase group","Other protein kinase group","CMGC protein kinase group","Nuclear hormone receptor subfamily 1 group F","AGC protein kinase group","CAMK protein kinase CAMK1 family","Other protein k
inase WEE family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKC family","CAMK protein kinase CHK1 subfamily","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Nuclear hormone receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CL
K families","1F. Retinoic acid-related orphans","CAMK-like (CAMKL) family","Other protein kinases","Cyclin-dependent kinase (CDK) family","CHK1 subfamily","WEE family","CDK4 subfamily"}

> <pathway_reactome>
{"DNA Repair","Cell Cycle","Vesicle-mediated transport","Gene expression (Transcription)","DNA Double-Strand Break Repair","Cell Cycle Checkpoints",Mitotic,"Membrane Trafficking","RNA Polymerase II Tr
anscription","Homology Directed Repair","G2/M Checkpoints","Mitotic G1 phase and G1/S transition","trans-Golgi Network Vesicle Budding","Generic Transcription Pathway","HDR through Homologous Recombin
ation (HRR) or Single Strand Annealing (SSA)","G2/M DNA damage checkpoint","G1 Phase","Golgi Associated Vesicle Biogenesis","Transcriptional regulation by RUNX3","HDR through Homologous Recombination 
(HRR)","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cyclin D associated events in G1","RUNX3 Regulates Immune Response and Cell Migration","Homologous DNA Pairing and Strand Excha
nge","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{WEE1}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{622864-54-4,622864544,PD-407824,PD407824,"PD 407824","9-HYDROXY-4-PHENYLPYRROLO(3,4-C)CARBAZOLE-1,3(2H,6H)-DIONE","9HYDROXY4PHENYLPYRROLO(3,4C)CARBAZOLE1,3(2H,6H)DIONE","9-HYDROXY-4-PHENYL-6H-PYRROLO
(3,4-C)CARBAZOLE-1,3-DIONE","9HYDROXY4PHENYL6HPYRROLO(3,4C)CARBAZOLE1,3DIONE",PD0407824,CHEMBL214253,SCHEMBL6516584,DTXSID40402483,HMS3262B15,HMS3269N21,HMS341,2694}

> <pdid>
PD005968

> <targets>
{"Checkpoint Kinases",Chk1,"Checkpoint Kinase (Chk)",Wee1}

> <classes>
{Cell Cycle/DNA Damage}

> <pubchem_cids>
{4369491}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
    4.9531   -1.9978    0.0000 N   0  0
    4.2010   -3.2956    0.0000 N   0  0
    2.7343   -2.9815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  1  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  4 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 12  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28308

> <plate>
Kinase v5-1

> <well>
M06

> <supplier_cmpd_name>
LY 364947

> <ctcr_id>
11450

> <supplier_cmpd_id>
2718

> <smiles>
[nH]1ncc(c1c1ccccn1)c1ccnc2ccccc12

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Y36494,396129-53-6,396129536,LY-364947,LY364947,4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)quinoline,4(3(pyridin2yl)1Hpyrazol4yl)quinoline,4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE,4(3PYRIDIN2YL1HPYRAZOL4
YL)QUINOLINE,"TGF-beta RI Kinase Inhibitor","TGFbeta RI Kinase Inhibitor","HTS 466284","TbetaR-I Inhibitor","TbetaRI Inhibitor","LY 364947",HTS-466284,HTS466284,CHEMBL261454,4-(3-pyridin-2-yl)(1h),4(3
pyridin2yl)(1h),T2048}

> <pdid>

> <targets>
{CK1¦Ä,MLK-7K,TGF¦ÂRI,TGF¦ÂRII,RIPK2}

> <classes>
{Metabolism,Apoptosis,MAPK,"Stem Cells"}

> <pubchem_cids>
{447966}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 20  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 N   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6890   -4.0818    0.0000 N   0  0
    0.2235   -5.5086    0.0000 C   0  0
    1.2235   -6.6267    0.0000 C   0  0
    0.7553   -8.0517    0.0000 C   0  0
   -0.7130   -8.3588    0.0000 C   0  0
   -1.1812   -9.7838    0.0000 F   0  0
   -1.7130   -7.2408    0.0000 C   0  0
   -1.2448   -5.8157    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  2  0
 17 11  1  0
  9 18  1  0
 18  2  1  0
 18  6  2  0
M  END
> <name>
UTKinase_V5

> <id>
28309

> <plate>
Kinase v5-1

> <well>
M08

> <supplier_cmpd_name>
CGP 57380

> <ctcr_id>
1280

> <supplier_cmpd_id>
2731

> <smiles>
Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12

> <pd_targets>
{BRSK2,MKNK2,MKNK1,AURKB,SGK1,LCK,CSNK1D,EIF2AK2,DYRK3,MTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","Other protein kinase group","AGC protein kinase group","TK protein kinase group","CK1 protein kinase group","CMGC protein kinase group","At
ypical protein kinase group","CAMK protein kinase CAMK1 family","CAMK protein kinase MAPKAPK family","Other protein kinase AUR family","AGC protein kinase SGK family","Tyrosine protein kinase Src fami
ly","CK1 protein kinase CK1 family","Other protein kinase PEK family","CMGC protein kinase DYRK family","Atypical protein kinase PIKK family","CAMK protein kinase BRSK subfamily","CAMK protein kinase 
MNK subfamily","Other protein kinase PKR","CMGC protein kinase Dyrk2 subfamily","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase 1",
"CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"CAMK-like (CAMKL) family","MAPK-Activated Protein Kinase (MAPKAPK) family","Other protein kinases","SGK family","TK: Tyrosine kinase","Casein 
kinase 1 (CK1) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","BRSK subfamily","MKN subfamily","
Aurora kinase (Aur) family","Non-receptor tyrosine kinases (nRTKs)","PEK family","Dyrk2 subfamily","FRAP subfamily","Src family","Other PEK family kinases"}

> <pathway_reactome>
{"Signal Transduction","Cell Cycle","Gene expression (Transcription)",Disease,"Signaling by Receptor Tyrosine Kinases",Mitotic,"RNA Polymerase II Transcription","Infectious disease","Signaling by FGFR
","M Phase","Generic Transcription Pathway","HIV Infection","Mitotic G2-G2/M phases","Influenza Infection","Signaling by FGFR4","Mitotic Metaphase and Anaphase","Transcriptional Regulation by TP53","H
ost Interactions of HIV factors","G2/M Transition","NS1 Mediated Effects on Host Pathways","Negative regulation of FGFR4 signaling","Mitotic Anaphase","Regulation of TP53 Activity","The role of Nef in
 HIV-1 replication and disease pathogenesis","Centrosome maturation","Inhibition of PKR","Spry regulation of FGF signaling","Separation of Sister Chromatids","Regulation of TP53 Expression and Degrada
tion","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Loss of proteins required for interphase microtubule organization from the centrosome","Regulati
on of TP53 Degradation","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"CGP 57380",522629-08-9,522629089,CGP-57380,CGP57380,"MNK1 Inhibitor","N3-(4-fluorophenyl)-1h-pyrazolo(3,4-d)pyrimidine-3,4-diamine","N3(4fluorophenyl)1hpyrazolo(3,4d)pyrimidine3,4diamine","3-N-(4-fl
uorophenyl)-2H-pyrazolo(3,4-d)pyrimidine-3,4-diamine","3N(4fluorophenyl)2Hpyrazolo(3,4d)pyrimidine3,4diamine",CHEMBL1240885,C11H9FN6,SCHEMBL987991,GTPL6010,4-Amino-5,4Amino5,T6440,"EMD 454861",2731,45
4861}

> <pdid>
PD002630

> <targets>
{Mnk1,Apoptosis,MNK}

> <classes>
{Apoptosis,MAPK/ERK Pathway}

> <pubchem_cids>
{11644425}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 26  0  0  0  0            999 V2000
    9.1117   -3.7308    0.0000 C   0  0
    7.8090   -2.9872    0.0000 O   0  0
    7.8007   -1.4864    0.0000 C   0  0
    9.0971   -0.7319    0.0000 C   0  0
    9.0919    0.7681    0.0000 C   0  0
    7.7903    1.5136    0.0000 C   0  0
    7.7851    3.0136    0.0000 Cl  0  0
    6.4939    0.7591    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 N   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 O   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  9  3  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 14  1  0
 24 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28310

> <plate>
Kinase v5-1

> <well>
M10

> <supplier_cmpd_name>
PQ 401

> <ctcr_id>
3485

> <supplier_cmpd_id>
2768

> <smiles>
COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23

> <pd_targets>
{IGF1R}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase InsR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","IGF1R signaling cascade","IRS-related events triggered by IGF1R"}

> <broad_targets>
{IGF1R}

> <broad_moa>
{"IGF-1 inhibitor"}

> <synonyms>
{PQ401,196868-63-0,196868630,"PQ 401",PQ-401,1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea,1(5Chloro2methoxyphenyl)3(2methylquinolin4yl)urea,"IGF-1R Inhibitor II","IGF1R Inhibitor II",TCM
DC-125497,TCMDC125497,UNII-2N3LV83S8J,UNII2N3LV83S8J,N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea,N(5Chloro2methoxyphenyl)N'(2methyl4quinolinyl)urea,2N3LV83S8J,CHEMBL439259,MFCD00160558
,K0061,T4324,"EMD 407248",2768,"PQ401 hydrochloride (196868-63-0(free base))",407248}

> <pdid>
PD002611

> <targets>
{"Insulin and insulin-like Receptors",IGF-1R}

> <classes>
{}

> <pubchem_cids>
{9549305}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 N   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 C   0  0
   -1.2942   -8.2509    0.0000 O   0  0
    0.0036   -7.4988    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  1  0
 18  8  1  0
 18 12  2  0
 16 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28311

> <plate>
Kinase v5-1

> <well>
M12

> <supplier_cmpd_name>
PI 828

> <ctcr_id>
3560

> <supplier_cmpd_id>
2814

> <smiles>
Nc1ccc(cc1)c2cccc3C(=O)C=C(Oc23)N4CCOCC4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{942289-87-4,942289874,PI-828,PI828,"PI 828",8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one,8(4Aminophenyl)2(4morpholinyl)4H1benzopyran4one,8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-
4-one,8(4aminophenyl)2(4morpholinyl)1benzopyran4one,"LY 294002, 4gamma-NH2","LY 294002, 4gammaNH2",8-(4-aminophenyl)-2-morpholino-4H-chromen-4-one,8(4aminophenyl)2morpholino4Hchromen4one,SCHEMBL137000
43,CHEBI:93710,DTXSI,2814,"EMD 440206",440206}

> <pdid>
PD021756

> <targets>
{"PI 3-Kinase",4'-NH2,"LY 294002",PI3K}

> <classes>
{}

> <pubchem_cids>
{25181195}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -5.1961   -3.0000    0.0000 C   0  0
   -5.1962   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28312

> <plate>
Kinase v5-1

> <well>
M14

> <supplier_cmpd_name>
NU 7026

> <ctcr_id>
1942

> <supplier_cmpd_id>
2828

> <smiles>
O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

> <pd_targets>
{RORC,PRKDC,MTOR,PIK3R1,PIK3CA}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Nuclear receptor",Kinase,Transferase,"Nuclear hormone receptor subfamily 1","Protein Kinase","Nuclear hormone receptor subfamily 1 group F","Atypical protein kinase gro
up","Nuclear hormone receptor subfamily 1 group F member 3","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Glycerophospholipid turnover","1F. Retinoic acid-related orphans",Atypical,"Phosphatidylinositol kinases","Lipid modifying kinase
s","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Other PIKK family kinases","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System",Disease,"RNA Polymerase II Transcription","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","
Generic Transcription Pathway","Cytosolic sensors of pathogen-associated DNA","Signaling by FGFR in disease","Transcriptional regulation by RUNX3","STING mediated induction of host immune responses","
Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","RUNX3 Regulates Immune Response and Cell Migration","IRF3-mediated induction of type I IFN","Regulation of TP53 Activity","FGFR1 mu
tant receptor activation","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
{PRKDC}

> <broad_moa>
{"DNA dependent protein kinase inhibitor","mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{DJ7RQT66H6,cc-674,cc674,154447-35-5,154447355,NU7026,"NU 7026",NU-7026,"DNA-PK Inhibitor II","DNAPK Inhibitor II",2-(Morpholin-4-yl)-benzo(h)chromen-4-one,2(Morpholin4yl)benzo(h)chromen4one,2-morphol
ino-4H-benzo(h)chromen-4-one,2morpholino4Hbenzo(h)chromen4one,2-morpholin-4-ylbenzo(h)chromen-4-one,2morpholin4ylbenzo(h)chromen4one,LY293646,2-(4-morpholinyl)-4H-naphtho(1,2(4morpholinyl)4Hnaphtho(1,
2-b)pyran-,2b)pyran,T2433,"EMD 260961",2828,260961}

> <pdid>
PD012539

> <targets>
{DNA-PK}

> <classes>
{}

> <pubchem_cids>
{9860529}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    7.7858   -9.1806    0.0000 N   0  0
    6.3110   -8.9071    0.0000 C   0  0
    5.3370  -10.0479    0.0000 O   0  0
    5.8106   -7.4921    0.0000 C   0  0
    6.7829   -6.3499    0.0000 C   0  0
    6.2798   -4.9368    0.0000 C   0  0
    4.8092   -4.6676    0.0000 C   0  0
    3.8322   -5.8080    0.0000 C   0  0
    4.3352   -7.2212    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 12 19  2  0
 19 20  1  0
 20 10  2  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 29 30  2  0
 30 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28313

> <plate>
Kinase v5-1

> <well>
M16

> <supplier_cmpd_name>
D 4476

> <ctcr_id>
2337

> <supplier_cmpd_id>
2902

> <smiles>
NC(=O)c1ccc(cc1)c2[nH]c(c3ccccn3)c(n2)c4ccc5OCCOc5c4

> <pd_targets>
{CSNK1A1,CSNK1D,MAPK14,CKA1,CSNK1E,PRKD1,CSNK1G1,CSNK1G2,TGFBR1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CK1 protein kinase group","CMGC protein kinase group","CAMK protein kinase group","TKL protein kinase group","CK1 protein kinase CK1 family","CMGC protein kinase MAPK 
family","CMGC protein kinase CK subfamily","CAMK protein kinase PKD family","TKL protein kinase STKR family","CMGC protein kinase p38 subfamily","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CK1: Casein kinase 1","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor ki
nases","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase D (PKD) family","TKL: Tyrosine kinase-like","p38 subfamily","Receptor serine/threonine kinase (R
STK) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{Disease,"Cell Cycle","Immune System",Metabolism,"Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Innate Immune System","Metabolism of lipids","Signaling by 
WNT in cancer","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Sphingolipid metabolism","Signaling by TGF-beta Receptor Complex in Cancer","Signaling by AMER1 mutants","G2/M Transition","Toll 
Like Receptor 5 (TLR5) Cascade","Sphingolipid de novo biosynthesis","Loss of Function of SMAD2/3 in Cancer","Truncations of AMER1 destabilize the destruction complex","Centrosome maturation","MyD88 ca
scade initiated on plasma membrane","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Loss of proteins required for interphase microtubule organization from the centrosome","MAP kinase activation","L
oss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{301836-43-1,301836431,D4476,"CK1 Inhibitor","casein kinase I inhibitor","D 4476",D-4476,"Casein Kinase I Inhibitor, D4476",CHEMBL410456,C23H18N4O3,K00227,MLS006010815,SCHEMBL373737,"InSolution&trade;
 Casein Kinase I Inhibitor, D4476",GTPL5940,SCHEMBL22857113,T2449,"EMD 218696",SY-D4476,2902,218696}

> <pdid>
PD012959

> <targets>
{"Casein Kinase 1",CK1}

> <classes>
{}

> <pubchem_cids>
{6419753}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
    1.2947   -3.7531    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -3.9021   -3.7405    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2080   -5.9890    0.0000 N   0  0
   -5.2111   -7.4899    0.0000 C   0  0
   -3.9120   -8.2400    0.0000 C   0  0
   -3.9120   -9.7400    0.0000 C   0  0
   -5.2110  -10.4900    0.0000 C   0  0
   -5.2110  -11.9900    0.0000 Br  0  0
   -6.5101   -9.7400    0.0000 C   0  0
   -6.5101   -8.2400    0.0000 C   0  0
   -7.8092   -7.4900    0.0000 N   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0127   -6.0039    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 15  1  0
 21 22  1  0
 13 23  1  0
 23 24  2  0
 24 10  1  0
 24 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28314

> <plate>
Kinase v5-1

> <well>
M18

> <supplier_cmpd_name>
EO 1428

> <ctcr_id>
5232

> <supplier_cmpd_id>
2908

> <smiles>
Cc1ccccc1C(=O)c2ccc(Nc3ccc(Br)cc3N)cc2Cl

> <pd_targets>
{MAPK11,MAPK12,MAPK13,MAPK14}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK11,MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"EO 1428",321351-00-2,321351002,EO-1428,EO1428,UNII-MV2RHJ680O,UNIIMV2RHJ680O,MV2RHJ680O,CHEMBL347496,(4-(2-amino-4-bromoanilino)-2-chlorophenyl)-(2-methylphenyl)methanone,(4(2amino4bromoanilino)2chl
orophenyl)(2methylphenyl)methanone,(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)(2-methylphenyl)methanone,(4((2Amino4bromophenyl)amino)2chlorophenyl)(2methylphenyl)methanone,(4-((2-amino-4-bromoph
enyl)ami,(4((2amino4bromophenyl)ami,2908,"EMD 506163",506163}

> <pdid>
PD021755

> <targets>
{"MAPK Family","p38 MAPK","p38 MAP Kinase Inhibitor VIII"}

> <classes>
{}

> <pubchem_cids>
{9801969}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 29  0  0  0  0            999 V2000
   16.7041   -5.6264    0.0000 Cl  0  0
   14.2041   -5.6264    0.0000 Cl  0  0
   11.7034  -12.7474    0.0000 Br  0  0
   10.4028  -12.0001    0.0000 C   0  0
    9.1053  -12.7527    0.0000 C   0  0
    7.8048  -12.0054    0.0000 C   0  0
    7.8016  -10.5053    0.0000 C   0  0
    6.5019   -9.7549    0.0000 C   0  0
    6.5009   -8.2541    0.0000 C   0  0
    5.2012   -7.5037    0.0000 C   0  0
    5.2002   -6.0029    0.0000 N   0  0
    3.9005   -5.2525    0.0000 C   0  0
    3.8995   -3.7516    0.0000 C   0  0
    2.5997   -3.0012    0.0000 N   0  0
    2.5988   -1.5004    0.0000 S   0  0
    3.8976   -0.7500    0.0000 O   0  0
    3.8982   -2.2498    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    9.0992   -9.7527    0.0000 C   0  0
   10.3998  -10.5001    0.0000 C   0  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  2  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 18  1  0
 27 22  1  0
  7 28  1  0
 28 29  2  0
 29  4  1  0
M  END
> <name>
UTKinase_V5

> <id>
28315

> <plate>
Kinase v5-1

> <well>
M20

> <supplier_cmpd_name>
H 89 dihydrochloride

> <ctcr_id>
4747

> <supplier_cmpd_id>
2910

> <smiles>
Cl.Cl.Brc1ccc(C=CCNCCNS(=O)(=O)c2cccc3cnccc23)cc1

> <pd_targets>
{MYLK,PRKACA,ROCK2,AKT1,PRKACB,PRKACG,GMNN,AKT2,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,PRKG1,CAMK2B,CAMKK2,ALDH1A1,AKT3,PRKAR2A,PRKAR2B,CSNK1A1,CSNK1D,CSNK1E,CSNK1G1,CSNK1G2
,MYLK3,RPS6KB1,FTL,PMP22,MAPT,LMNA,MAPK1,RPS6KA5,GSK3B,CHEK2,LIMK1,CHEK1,MARK2,KDR,DAPK3,RPS6KA3,MARK3,AURKA,CDK5,PRKAA1,AURKB,ROCK1,PRKD2,STK3,SGK2,CDK1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Other cytosolic protein","Other nuclear protein",Kinase,Oxidoreductase,"Protein Kinase","CAMK protein kinase group","AGC protein kinase group","Other protein kinase gro
up","CK1 protein kinase group","CMGC protein kinase group","CAMK protein kinase MLCK family","AGC protein kinase PKA family","AGC protein kinase DMPK family","AGC protein kinase AKT family","AGC prote
in kinase PKC family","AGC protein kinase PKG family","CAMK protein kinase CAMK2 family","Other protein kinase CAMKK family","CK1 protein kinase CK1 family","AGC protein kinase RSK family","CMGC prote
in kinase MAPK family","CMGC protein kinase GSK family","AGC protein kinase ROCK subfamily","AGC protein kinase PKC alpha subfamily","Other protein kinase Meta subfamily","AGC protein kinase p70 subfa
mily","CMGC protein kinase ERK1","AGC protein kinase MSK subfamily","TKL protein kinase group","TK protein kinase group","STE protein kinase group","CAMK protein kinase RAD53 family","TKL protein kina
se LISK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase VEGFR family","CAMK protein kinase DAPK family","Other protein kinase AUR family","CMGC protein kinase CDK family","CAMK pro
tein kinase PKD family","STE protein kinase STE20 family","AGC protein kinase SGK family","TKL protein kinase LIMK subfamily","CAMK protein kinase CHK1 subfamily","CAMK protein kinase MARK subfamily",
"AGC protein kinase PKC iota subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase CDK5 subfamily","CAMK protein kinase AMPK subfamily","AGC protein kinase PKC delta subfamily","STE prote
in kinase MST subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC families","Receptor kinases","CK1: Casein kinase 1",
"CMGC: Containing CDK",MAPK,GSK3,"CLK families","Myosin Light Chain Kinase (MLCK) family","Protein kinase A (PKA) family","DMPK family","Akt (Protein kinase B","PKB) family","Protein kinase G (PKG) fa
mily","CAMK2 family","Other protein kinases","RSK family","Protein kinase C (PKC) family","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","Glycogen synthase kinase (GS
K) family","Rho kinase","CAMKK family","p70 subfamily","Delta subfamily","ERK subfamily","MSK subfamily","GSK subfamily","Meta subfamily","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 ki
nases","CAMK-like (CAMKL) family","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","Death-associated kinase (DAPK) family","Cyclin-dependent kinase (CDK) family","Protein kinase D (PKD) family","STE2
0 family","SGK family","CHK1 subfamily","LIM domain kinase (LISK) family","MARK subfamily","Iota subfamily","Receptor tyrosine kinases (RTKs)","Alpha subfamily","RSK subfamily","Aurora kinase (Aur) fa
mily","CDK5 subfamily","AMPK subfamily","MST subfamily","CDK1 subfamily","LIMK subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Cell Cycle","Developmental Biology","Gene expression (Transcription)",Hemostasis,"Neuronal System",Metabolism,"Vesicle-mediated transport",Disease,"Immune System","Signaling by
 Rho GTPases",Mitotic,"Nervous system development","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Platelet homeostasis","Transmission across Chemical Synapses","Biological
 oxidations","Intracellular signaling by second messengers","MTOR signalling","Membrane Trafficking","Signaling by GPCR","Diseases of signal transduction by growth factor receptors and second messenge
rs","Innate Immune System","Infectious disease","RHO GTPase Effectors","Mitotic G2-G2/M phases","Axon guidance","Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","Signaling by Ins
ulin receptor","Nitric oxide stimulates guanylate cyclase","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization of compounds","DAG and IP3 signaling","mTORC1-
mediated signalling","trans-Golgi Network Vesicle Budding","GPCR downstream signalling","Signaling by WNT in cancer","EGR2 and SOX10-mediated initiation of Schwann cell myelination","M Phase","Toll-li
ke Receptor Cascades","SARS-CoV Infections","RHO GTPases activate PAKs","G2/M Transition","Semaphorin interactions","Transcriptional Regulation by TP53","G1/S Transition","Insulin receptor signalling 
cascade","cGMP effects","Activation of NMDA receptors and postsynaptic events","Ethanol oxidation","CaM pathway","Golgi Associated Vesicle Biogenesis","G alpha (i) signalling events","Signaling by AME
R1 mutants","Mitotic Metaphase and Anaphase","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-1 Infection","Centrosome maturation","Sema4D in semaphorin signaling","Regulation of TP53 Activity","Activa
tion of the pre-replicative complex","IRS-mediated signalling","Post NMDA receptor activation events","Calmodulin induced events","Visual phototransduction","Truncations of AMER1 destabilize the destr
uction complex","Mitotic Anaphase","MyD88 cascade initiated on plasma membrane","SARS-CoV-1 Genome Replication and Transcription","Loss of proteins required for interphase microtubule organization fro
m the centrosome","Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Expression and Degradation","PI3K Cascade","CREB1 phosphorylation through NMDA receptor-mediated activati
on of RAS signaling","Activation of AMPK downstream of NMDARs","PKA-mediated phosphorylation of CREB","The phototransduction cascade","Nuclear Envelope (NE) Reassembly","MAP kinase activation","Replic
ation of the SARS-CoV-1 genome","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","PKB-mediated events","Ras activation upon Ca2+ influx through NMDA receptor","PKA activation",I
nactivation,"recovery and regulation of the phototransduction cascade","Initiation of Nuclear Envelope (NE) Reformation","MAPK targets/ Nuclear events mediated by MAP kinases","PDE3B signalling","ERK/
MAPK targets","CREB phosphorylation","ERKs are inactivated","DNA Repair","Programmed Cell Death","Transport of small molecules","DNA Double-Strand Break Repair","Signaling by Nuclear Receptors",Apopto
sis,"Metabolism of lipids","Signaling by Hippo","Ion channel transport","Homology Directed Repair","ESR-mediated signaling","Signaling by VEGF","Caspase activation via extrinsic apoptotic signalling p
athway","Oncogenic MAPK signaling","Sphingolipid metabolism","Stimuli-sensing channels","Regulation of mitotic cell cycle","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)"
,"Extra-nuclear estrogen signaling","VEGFA-VEGFR2 Pathway","Caspase activation via Dependence Receptors in the absence of ligand","Glutamate binding","activation of AMPA receptors and synaptic plastic
ity","Signaling by RAS mutants","Sphingolipid de novo biosynthesis","APC/C-mediated degradation of cell cycle proteins","HDR through Homologous Recombination (HRR)","Estrogen-stimulated signaling thro
ugh PRKCZ","VEGFR2 mediated cell proliferation","Trafficking of AMPA receptors","Signaling downstream of RAS mutants","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Ho
mologous DNA Pairing and Strand Exchange","Trafficking of GluR2-containing AMPA receptors","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids","APC/C:Cdc20 mediated
 degradation of mitotic proteins","Presynaptic phase of homologous DNA pairing and strand exchange","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkp
oint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{GSG2,PKIA,PRKACA}

> <broad_moa>
{"PKA inhibitor"}

> <synonyms>
{89?2HC,"Protein kinase inhibitor H-89 dihydrochloride","Protein kinase inhibitor H89 dihydrochloride","N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride","N(2(4bromocinnamyl
amino)ethyl)isoquinoline5sulfonamide dihydrochloride",AK685750,A805668,Q27225142,"EMD 371963",2910,EI-196,371963,"H 89 dihydrochloride",H-89?2HCl}

> <pdid>
PD005269

> <targets>
{PKA}

> <classes>
{}

> <pubchem_cids>
{2733490}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 20  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -5.1984   -1.4978    0.0000 C   0  0
   -6.4971   -0.7455    0.0000 N   0  0
   -7.7984   -1.4932    0.0000 N   0  0
   -9.0971   -0.7410    0.0000 C   0  0
  -10.3977   -1.4883    0.0000 S   0  0
   -9.0945    0.7590    0.0000 N   0  0
    3.7998   -1.1250    0.0000 Cl  0  0
    5.0990   -0.3754    0.0000 Cu  0  0
    6.3983   -1.1250    0.0000 Cl  0  0
  1  2  2  3
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  1  1  0
  5  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  2  3
 10 11  1  0
 11  4  1  0
  9 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 18 19  1  0
 19 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28316

> <plate>
Kinase v5-1

> <well>
M22

> <supplier_cmpd_name>
FPA 124

> <ctcr_id>
3674

> <supplier_cmpd_id>
2926

> <smiles>
C1=CC=C2C(=C1)C(=O)C(=CO2)C=NNC(=S)N.Cl[Cu]Cl

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{"FPA 124",902779-59-3,902779593,2926}

> <pdid>
PD153752

> <targets>
{Akt/PKB,PKB}

> <classes>
{}

> <pubchem_cids>
{102586612}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -3.8813    1.4408    0.0000 C   0  0
   -5.0460    2.3579    0.0000 S   0  0
   -6.2823    1.5084    0.0000 C   0  0
   -7.6935    2.0116    0.0000 C   0  0
   -8.8360    1.0396    0.0000 N   0  0
   -7.9646    3.4869    0.0000 O   0  0
   -5.8565    0.0701    0.0000 C   0  0
   -6.7662   -1.1203    0.0000 O   0  0
   -6.1900   -2.5061    0.0000 C   0  0
   -7.1014   -3.6986    0.0000 C   0  0
   -8.5886   -3.5028    0.0000 C   0  0
   -9.5018   -4.6927    0.0000 C   0  0
   -8.9279   -6.0786    0.0000 C   0  0
   -7.4407   -6.2745    0.0000 C   0  0
   -6.5275   -5.0845    0.0000 C   0  0
   -5.0395   -5.2806    0.0000 C   0  0
   -4.4648   -6.6661    0.0000 F   0  0
   -4.1266   -4.0904    0.0000 F   0  0
   -3.5523   -5.4758    0.0000 F   0  0
   -4.3570    0.0307    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 11 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
 15 28  1  0
 28  9  2  0
  8 29  1  0
 29  5  2  0
 29 30  1  0
 30 31  2  0
 31  3  1  0
 31 32  1  0
 32 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28317

> <plate>
Kinase v5-1

> <well>
O04

> <supplier_cmpd_name>
GW 843682X

> <ctcr_id>
4653

> <supplier_cmpd_id>
2977

> <smiles>
COc1cc2ncn(c3sc(C(N)=O)c(OCc4ccccc4C(F)(F)F)c3)c2cc1OC

> <pd_targets>
{ITK,CLK4,BRSK1,PLK3,EGFR,NEK2,JAK2,SLK,PLK2,MELK,GSK3B,PLK4,FLT1,AXL,PLK1,KDR,KIT,MAP4K5,LCK,NTRK1,PTK2,RPS6KA3,MAPKAPK5,FGFR1,PDGFRB,CSF1R,AURKA,RPS6KA5,JAK3,ERBB2,TSSK1B,TSSK2,LIMK1,PRKX,FLT4,SRC,P
TK2B,PRKG1,DYRK1A,STK3,FLT3,MAP4K4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","CAMK protein kinase group","Other protein kinase group","STE protein kinase group","AGC protein kinase group","TK
L protein kinase group","Tyrosine protein kinase Tec family","CMGC protein kinase CLK family","CAMK protein kinase CAMK1 family","Other protein kinase PLK family","Tyrosine protein kinase EGFR family"
,"Other protein kinase NEK family","Tyrosine protein kinase JakA family","STE protein kinase STE20 family","CMGC protein kinase GSK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kin
ase Axl family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Trk family","Tyrosine protein kinase Fak family","AGC protein kinase RSK family","C
AMK protein kinase MAPKAPK family","Tyrosine protein kinase FGFR family","Other protein kinase AUR family","CAMK protein kinase TSSK family","TKL protein kinase LISK family","AGC protein kinase PKA fa
mily","AGC protein kinase PKG family","CMGC protein kinase DYRK family","CAMK protein kinase BRSK subfamily","STE protein kinase SLK subfamily","Other protein kinase PLK2","CAMK protein kinase MELK su
bfamily","STE protein kinase KHS subfamily","AGC protein kinase RSK subfamily","CAMK protein kinase MAPKAPK subfamily","AGC protein kinase MSK subfamily","TKL protein kinase LIMK subfamily","CMGC prot
ein kinase Dyrk1 subfamily","STE protein kinase MST subfamily","STE protein kinase MSN subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs o
f yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","TK: Tyrosine kinase","CLK family","CAMK-like (CAMKL) family","Other protein kinases","STE20 family","Glyc
ogen synthase kinase (GSK) family","RSK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Testis specific kinase (TSSK) family","TKL: Tyrosine kinase-like","Protein kinase A (PKA) family","Pro
tein kinase G (PKG) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Non-receptor tyrosine kinases (nRTKs)","BRSK subfamily","Polo-like kinase (PLK) family","Rec
eptor tyrosine kinases (RTKs)","NIMA (never in mitosis gene a)- related kinase (NEK) family","SLK subfamily","MELK subfamily","GSK subfamily","KHS subfamily","RSK subfamily","MAPKAPK subfamily","Auror
a kinase (Aur) family","MSK subfamily","LIM domain kinase (LISK) family","Dyrk1 subfamily","MST subfamily","MSN subfamily","Tec family","Type I RTKs: ErbB (epidermal growth factor) receptor family","J
anus kinase (JakA) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT
3 receptor family","Src family","Type VII RTKs: Neurotrophin receptor/Trk family","Fak family","Type V RTKs: FGF (fibroblast growth factor) receptor family","LIMK subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)","Signal Transduction","Cell Cycle",Disease,"Developmental Biology",Hemostasis,"Cellular responses to external stimuli","Adaptive Immune System","RNA 
Polymerase II Transcription","Signaling by GPCR",Mitotic,"Infectious disease","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers
","Innate Immune System","Intracellular signaling by second messengers","Cytokine Signaling in Immune system","Nervous system development","Platelet homeostasis","Signaling by Hippo","Cellular respons
es to stress","TCR signaling","Generic Transcription Pathway","GPCR downstream signalling","Regulation of mitotic cell cycle","Mitotic G1 phase and G1/S transition","Leishmania infection","SARS-CoV In
fections","Mitotic G2-G2/M phases","Signaling by VEGF","Signaling by KIT in disease","HIV Infection","Signaling by NTRKs","Toll-like Receptor Cascades","Signaling by FGFR in disease","PIP3 activates A
KT signaling","Signaling by Interleukins","Axon guidance","Nitric oxide stimulates guanylate cyclase","Signaling by Insulin receptor","Cellular Senescence","Generation of second messenger molecules","
Transcriptional Regulation by TP53","G alpha (q) signalling events","APC/C-mediated degradation of cell cycle proteins","G1 Phase","Leishmania parasite growth and survival","SARS-CoV-1 Infection","G2/
M Transition","VEGF ligand-receptor interactions","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","Host Interactions of HIV factors","Signaling by NTRK1 (TRKA)","Parasite infection","Toll Like
 Receptor 5 (TLR5) Cascade","Signaling by FGFR1 in disease","Negative regulation of the PI3K/AKT network","Transcriptional Regulation by VENTX","Interleukin-2 family signaling","Semaphorin interaction
s","cGMP effects","G0 and Early G1","Insulin receptor signalling cascade","Oxidative Stress Induced Senescence","Regulation of TP53 Activity","Gastrin-CREB signalling pathway via PKC and MAPK","Activa
tion of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Cyclin D associated events in G1","Anti-inflammatory response favouring Leishmania parasite infection","SARS-CoV-1 Genome Repli
cation and Transcription","Centrosome maturation","VEGF binds to VEGFR leading to receptor dimerization","VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","The role of Nef in HIV-
1 replication and disease pathogenesis","Signalling to ERKs","Leishmania phagocytosis","MyD88 cascade initiated on plasma membrane","FGFR1 mutant receptor activation",PI5P,"PP2A and IER3 Regulate PI3K
/AKT Signaling","Interleukin-15 signaling","Sema4D in semaphorin signaling","Interleukin-2 signaling","IRS-mediated signalling","Regulation of TP53 Activity through Phosphorylation","EGFR Transactivat
ion by Gastrin","APC/C:Cdc20 mediated degradation of mitotic proteins","CD163 mediating an anti-inflammatory response","Replication of the SARS-CoV-1 genome","Loss of proteins required for interphase 
microtubule organization from the centrosome","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Prolonged ERK activation events","FCGR3A-mediated phagoc
ytosis","MAP kinase activation","Signaling by activated point mutants of FGFR1","Sema4D induced cell migration and growth-cone collapse","ADORA2B mediated anti-inflammatory cytokines production","Sign
alling to RAS","PI3K Cascade","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Loss of Nlp from mitotic centrosomes","Nef Mediated CD4 Down-re
gulation","ARMS-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","APC-Cdc20 mediated degradation of Nek2A","CREB phosphorylation"}

> <broad_targets>
{PLK1,PLK3}

> <broad_moa>
{"PLK inhibitor"}

> <synonyms>
{GW843682X,660868-91-7,660868917,"GW 843682X",GW843682,GW-843682X,C22H18F3N3O4S,Kinome_3462,Kinome3462,Kinome-3462,"Kinome 3462","thiophene deriv., 20",MLS006010260,"BMCL191018 Compound 2",CHEMBL51449
9,SCHEMBL1286884,BDBM25120,CHEBI:91334,DTXSID80431373,BCPP000216,HMS3265C07,HMS3265C08,HMS,2977}

> <pdid>
PD003624

> <targets>
{"Polo-like Kinase",PLK}

> <classes>
{}

> <pubchem_cids>
{9826308}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0875    3.7680    0.0000 F   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Cl  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 N   0  0
   -3.9099   -8.2497    0.0000 C   0  0
   -3.9099   -9.7497    0.0000 C   0  0
   -2.6109  -10.4997    0.0000 O   0  0
   -1.3119   -9.7497    0.0000 C   0  0
   -1.3118   -8.2497    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 16 18  2  0
 18 11  1  0
  9 19  2  0
 19  5  1  0
 19 20  1  0
 20 21  2  0
 21  3  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28318

> <plate>
Kinase v5-1

> <well>
O06

> <supplier_cmpd_name>
Iressa

> <ctcr_id>
6466

> <supplier_cmpd_id>
3000

> <smiles>
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCOCC4

> <pd_targets>
{FLT3,EGFR,ERBB2,MAPK9,LCK,SLK,STK10,SBK1,RIPK2,GAK,MKNK1,NLK,HCK,SIK2,MAPK4,PRKD2,PRKD3,LIMK1,PHKG1,TNIK,CAMK2G,KIT,EPHB1,TUBA1A,CSNK1E,STK17B,PIM1,PIM3,MAP4K5,ERBB3,ERBB4,CHEK2,MKNK2,LYN,MYLK2,SRC,S
TK17A,DMPK,IRAK4,AXL,BLK,BRAF,RPS6KA4,EPHA8,TXK,KDR,ABL1,IRAK1,MAP3K3,MAP3K2,MAPK10,MAPK14,HIPK4,ABL2,NUAK2,IRAK3,RET,BACE1,PIP4K2C,DCLK3,EPHA5,CIT,MINK1,CDK7,NORA,FLT4,MET,CAMK2D,PHKG2,ABCB11,LTK,MAP
T,FRK,EPHA6,STK36,EPHA1,MAPK6,MAP3K19,MAP2K5,EPHB4,CSNK1D,DAPK3,TNK2,EPHA3,FGR,PTK6,PRKD1,EPHB6,ULK3,MAP4K4,EPHA7,BRSK1,ABCG2,ABCC4}

> <pathway_gtopdb>
{Enzyme,"Structural protein","Unclassified protein",Transporter,"Other cytosolic protein",Kinase,Protease,Transferase,"Primary active transporter","Protein Kinase","Cysteine protease","Aspartic protea
se","ATP-binding cassette","TK protein kinase group","CMGC protein kinase group","STE protein kinase group","Other protein kinase group","TKL protein kinase group","CAMK protein kinase group","Cystein
e protease CA clan","CK1 protein kinase group","AGC protein kinase group","Aspartic protease AA clan","ABCB subfamily","ABCG subfamily","ABCC subfamily","Tyrosine protein kinase PDGFR family","Tyrosin
e protein kinase EGFR family","CMGC protein kinase MAPK family","Tyrosine protein kinase Src family","STE protein kinase STE20 family","Other protein kinase NKF1 family","TKL protein kinase RIPK famil
y","Other protein kinase NAK family","CAMK protein kinase MAPKAPK family","CAMK protein kinase CAMK1 family","CAMK protein kinase PKD family","TKL protein kinase LISK family","CAMK protein kinase PHk 
family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Eph family","Cysteine protease C1A family","CK1 protein kinase CK1 family","CAMK protein kinase DAPK family","CAMK protein kinase PI
M family","CAMK protein kinase RAD53 family","CAMK protein kinase MLCK family","AGC protein kinase DMPK family","TKL protein kinase IRAK family","Tyrosine protein kinase Axl family","TKL protein kinas
e RAF family","AGC protein kinase RSK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Abl family","STE protein kinase STE11 family","CMGC p
rotein kinase DYRK family","Tyrosine protein kinase Ret family","Aspartic protease A1A subfamily","CAMK protein kinase DCAMK1 family","CMGC protein kinase CDK family","Tyrosine protein kinase Met fami
ly","Tyrosine protein kinase Alk family","Other protein kinase ULK family","STE protein kinase STE7 family","Tyrosine protein kinase Ack family","CMGC protein kinase JNK subfamily","STE protein kinase
 SLK subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase nmo subfamily","CAMK protein kinase QIK subfamily","CMGC protein kinase ERK3","TKL protein kinase LIMK subfamily","STE protein 
kinase MSN subfamily","STE protein kinase KHS subfamily","AGC protein kinase GEK subfamily","AGC protein kinase MSK subfamily","STE protein kinase MEKK2","CMGC protein kinase p38 subfamily","CMGC prot
ein kinase HIPK subfamily","CAMK protein kinase NuaK subfamily","AGC protein kinase CRIK subfamily","CMGC protein kinase CDK7 subfamily","CAMK protein kinase BRSK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets",Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)",Tubulins,"Peptidases and proteinases","ATP-binding cassette transporter family","Receptor kinases",
"CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CK1: Casein kinase 1","AGC: C
ontaining PKA",PKG,"PKC families","AA: Aspartic (A) Peptidases","Lipid modifying kinases","ABCB subfamily","ABCG subfamily","ABCC subfamily","TK: Tyrosine kinase","Mitogen-activated protein kinases (M
AP kinases)","STE20 family","Other protein kinases","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","CAMK-like (CAMKL) family","Protein kinase D (PKD) family","Phosphoryla
se kinase (PHK) family","CAMK2 family","Casein kinase 1 (CK1) family","Death-associated kinase (DAPK) family","PIM family","Myosin Light Chain Kinase (MLCK) family","DMPK family","RSK family","STE11 f
amily","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","A1: Pepsin","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","DCAMKL family","Cyclin-de
pendent kinase (CDK) family","STE7 family","Receptor tyrosine kinases (RTKs)","JNK subfamily","Non-receptor tyrosine kinases (nRTKs)","SLK subfamily","NKF1 family","Receptor interacting protein kinase
 (RIPK) family","Numb-associated kinase (NAK) family","MKN subfamily","nmo subfamily","QIK subfamily","ERK subfamily","LIM domain kinase (LISK) family","MSN subfamily","KHS subfamily","CHK1 subfamily"
,"GEK subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","RAF family","MSK subfamily","p38 subfamily","HIPK subfamily","NuaK subfamily","Other DMPK family kinases","CDK7 subfamily","U
nc-51-like kinase (ULK) family","STE20 subfamily","BRSK subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Src family","LI
MK subfamily","Type XIII RTKs: Ephrin receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Tec family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor fam
ily","Abl family","Type XIV RTKs: RET","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Ack family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Immune System",Disease,"Vesicle-mediated transport",Metabolism,"Cellular responses to external stimuli","Neuronal System","Cell Cycle","Gene expression 
(Transcription)","Muscle contraction","Metabolism of proteins","Programmed Cell Death",Hemostasis,"Signaling by Receptor Tyrosine Kinases","Signaling by GPCR","Nervous system development","Innate Immu
ne System","Infectious disease","Membrane Trafficking","Signaling by WNT","MAPK family signaling cascades","Metabolism of lipids","Metabolism of carbohydrates","Cellular responses to stress","Transmis
sion across Chemical Synapses","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"RNA Polymerase II Transcription","Cardiac conduction","Cytokine Signaling in 
Immune system","Amyloid fiber formation","Signaling by Rho GTPases","Intracellular signaling by second messengers",Apoptosis,"Signaling by Hedgehog","Abacavir transport and metabolism","Platelet activ
ation","signaling and aggregation","Signaling by Insulin receptor","GPCR downstream signalling","Axon guidance","Toll-like Receptor Cascades","HIV Infection","Neutrophil degranulation","trans-Golgi Ne
twork Vesicle Budding","Signaling by FGFR","Beta-catenin independent WNT signaling","MAPK6/MAPK4 signaling","Sphingolipid metabolism","Glycogen metabolism","Cellular Senescence","Neurotransmitter rece
ptors and postsynaptic signal transmission","Signaling by KIT in disease","Mitotic G2-G2/M phases","FLT3 signaling in disease","Generic Transcription Pathway","Leishmania infection","Signaling by NTRK
s","Ion homeostasis","Signaling by VEGF","Fc epsilon receptor (FCERI) signaling","Signaling by Interleukins","RHO GTPase Effectors","Metabolism of steroids","PIP3 activates AKT signaling","Caspase act
ivation via extrinsic apoptotic signalling pathway","Mitotic G1 phase and G1/S transition","Hedgehog 'on' state","Abacavir transmembrane transport","Response to elevated platelet cytosolic Ca2+","Insu
lin receptor signalling cascade","G alpha (q) signalling events","Semaphorin interactions","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","Golgi Associated Vesicle Biogenesis
","Signaling by FGFR4","Ca2+ pathway","Sphingolipid de novo biosynthesis","Glycogen breakdown (glycogenolysis)","Oxidative Stress Induced Senescence","Activation of NMDA receptors and postsynaptic eve
nts","Drug resistance of KIT mutants","EPH-Ephrin signaling","G2/M Transition","Signaling by FLT3 ITD and TKD mutants","Transcriptional Regulation by TP53","Leishmania parasite growth and survival","S
ignaling by NTRK1 (TRKA)","Toll Like Receptor 2 (TLR2) Cascade","VEGFA-VEGFR2 Pathway","Transcriptional regulation by RUNX1","L1CAM interactions","FCERI mediated Ca+2 mobilization","Parasite infection
","Interleukin-1 family signaling","Signaling by ROBO receptors","RET signaling","RHO GTPases activate CIT","HIV Life Cycle","VEGF ligand-receptor interactions","Bile acid and bile salt metabolism","P
TEN Regulation","Caspase activation via Dependence Receptors in the absence of ligand","Negative regulation of the PI3K/AKT network","G1 Phase","Platelet degranulation","IRS-mediated signalling","Gast
rin-CREB signalling pathway via PKC and MAPK","Sema4D in semaphorin signaling","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Negative re
gulation of FGFR4 signaling","Post NMDA receptor activation events","Dasatinib-resistant KIT mutants","EPHB-mediated forward signaling","Centrosome maturation","STAT5 activation downstream of FLT3 ITD
 mutants","Regulation of TP53 Activity","Anti-inflammatory response favouring Leishmania parasite infection","Signalling to ERKs","Toll Like Receptor TLR6:TLR2 Cascade","RUNX1 regulates transcription 
of genes involved in BCR signaling","Recycling pathway of L1","EPHA-mediated growth cone collapse","VEGFR2 mediated cell proliferation","Leishmania phagocytosis","Interleukin-1 signaling","Role of ABL
 in ROBO-SLIT signaling","Late Phase of HIV Life Cycle","VEGF binds to VEGFR leading to receptor dimerization","Synthesis of bile acids and bile salts","Regulation of PTEN stability and activity","Sig
nalling to ERK5",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Cyclin D associated events in G1","PI3K Cascade","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone col
lapse","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Spry regulation of FGF signaling","Nef and signal transduction","CREB1 
phosphorylation through NMDA receptor-mediated activation of RAS signaling","Loss of proteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Expression and D
egradation","FCGR3A-mediated IL10 synthesis","Signalling to RAS","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Prolonged ERK activation events","Long-term potentiation","FCGR3A-mediated pha
gocytosis","Regulation of TP53 Activity through Acetylation","Transcription of the HIV genome","Sema4D mediated inhibition of cell attachment and migration","Synthesis of bile acids and bile salts via
 7alpha-hydroxycholesterol","Activation of AMPK downstream of NMDARs","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","activated TAK1 mediates p38 MAPK activa
tion","Ras activation upon Ca2+ influx through NMDA receptor","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","p38MAPK events","ARMS-mediated activation","PI5P Regulates TP53 A
cetylation","HIV Transcription Elongation","Activation of the AP-1 family of transcription factors","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing 
HIV-1 Tat"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{15215-EP2298768A1,15215EP2298768A1,Gefitinib,184475-35-2,184475352,Iressa,ZD1839,Irressat,"gefitinib (zd1839)","ZD 1839",ZD-1839,UNII-S65743JHBS,UNIIS65743JHBS,4-(3'-Chloro-4'-fluoroanilino)-7-methox
y-6-(3-morpholinopropoxy)quinazoline,4(3'Chloro4'fluoroanilino)7methoxy6(3morpholinopropoxy)quinazoline,MFCD04307832,CHEMBL939,S65743JHBS,CHEBI:49668,NC,T1181,715055,S1025,3000,Prestw-1270,"NSC 715055
",gefitinib,Gefitinib(Iressa),"Gefitinib (ZD1839)",GEFITINIB}

> <pdid>
PD003385

> <targets>
{EGFR(HER),EGFR}

> <classes>
{"Tyrosine kinase inhibitor","Protein Tyrosine Kinase"}

> <pubchem_cids>
{123631}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 20  0  0  0  0            999 V2000
    2.4192   -8.3243    0.0000 C   0  0
    1.2028   -7.4466    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6079   -6.7003    0.0000 C   0  0
   -0.2222   -7.9149    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  2  0
 16 17  1  0
 16 18  1  0
 18  2  2  0
M  END
> <name>
UTKinase_V5

> <id>
28319

> <plate>
Kinase v5-1

> <well>
O08

> <supplier_cmpd_name>
SU 5416

> <ctcr_id>
1850

> <supplier_cmpd_id>
3037

> <smiles>
Cc1[nH]c(C=C2C(=O)Nc3ccccc23)c(C)c1

> <pd_targets>
{KDR,FLT1,PDGFRB,ALK,FLT4,PDGFRA,FGFR1,MAPT,KMT2A,MEN1,GMNN,FLT3,SRC,BLM,USP2,KIT,EGFR,AVPR1A,LMNA,MAPK1,FGFR2,FGFR3,FGFR4,ABL1,CSF1R,PMP22,FFP,RECQL,NPC1,NPSR1,OXTR,MTOR,RET,ZAP70,PLK4,FRK,RPS6KA3,MA
P4K4,JAK2,STK3,SGK2,AURKA,CSNK1D,JAK3,FER,STK17A,MARK3,ITK,INSR,CAMK2D,RPS6KB1,LCK,CAMK2B,NTRK2,MAP4K5,CSNK1G2,AURKB,TYK2,CSNK1A1,PRKD3,CHEK2,MARK2,CAMK1,FYN,CLK2,AXL,NTRK3,BRSK1,PRKD2,SLK,LYN,NTRK1,M
INK1,BLK,ROCK1,IRAK4,CLK4,SYK,CAMK2G,CSNK1G3,PHKG2,IRAK1,MAP4K2,PTK2B,PKN2,PDPK1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator","Unclassified protein","Membrane receptor","Other nuclear protein",Transporter,Kinase,Reader,Protease,"Family A G protein-coupled receptor",Tra
nsferase,"Protein Kinase",Bromodomain,"Cysteine protease","Peptide receptor (family A GPCR)","TK protein kinase group","TKL protein kinase group","Cysteine protease CA clan","Short peptide receptor (f
amily A GPCR)","CMGC protein kinase group","Atypical protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","TKL protein kinase STKR family","Tyrosine prot
ein kinase FGFR family","Tyrosine protein kinase Src family","Cysteine protease C19 family","Tyrosine protein kinase EGFR family","Vasopressin and oxytocin receptor","CMGC protein kinase MAPK family",
"Tyrosine protein kinase Abl family","Cysteine protease C1A family","Neuropeptide receptor","Atypical protein kinase PIKK family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Syk fami
ly","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","Other protein kinase group","AGC protein kinase group","STE protein kinase group","C
K1 protein kinase group","CAMK protein kinase group","Other protein kinase PLK family","AGC protein kinase RSK family","STE protein kinase STE20 family","Tyrosine protein kinase JakA family","AGC prot
ein kinase SGK family","Other protein kinase AUR family","CK1 protein kinase CK1 family","Tyrosine protein kinase Fer family","CAMK protein kinase DAPK family","CAMK protein kinase CAMK1 family","Tyro
sine protein kinase Tec family","Tyrosine protein kinase InsR family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Trk family","CAMK protein kinase PKD family","CAMK protein kinase RAD5
3 family","CMGC protein kinase CLK family","Tyrosine protein kinase Axl family","AGC protein kinase DMPK family","TKL protein kinase IRAK family","CAMK protein kinase PHk family","Tyrosine protein kin
ase Fak family","AGC protein kinase PKN family","AGC protein kinase PDK1 subfamily","AGC protein kinase RSK subfamily","STE protein kinase MSN subfamily","STE protein kinase MST subfamily","CAMK prote
in kinase MARK subfamily","AGC protein kinase p70 subfamily","STE protein kinase KHS subfamily","Tyrosine protein kinase SrcA","CAMK protein kinase BRSK subfamily","STE protein kinase SLK subfamily","
AGC protein kinase ROCK subfamily","CK1 protein kinase CK1-g"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Catalytic receptors","Chromatin modifying enzymes","Peptidases and proteinases","G protein-coupled receptors","Kinases (EC 2.7.x.x)","SLC superfamily of solute carrier
s","Receptor kinases","2.1.1.43 Histone methyltransferases (HMTs)","CA: Cysteine (C) Peptidases","Vasopressin and oxytocin receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","SLC65 NPC-type ch
olesterol transporters","Neuropeptide S receptor",Atypical,"TK: Tyrosine kinase","C19: Ubiquitin-specific protease","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-r
elated kinases (PIKK) family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","FRAP subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) recep
tor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Src f
amily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Abl family","Type XIV RTKs: RET","Syk family","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile
 11","Sterile 20 kinases","CK1: Casein kinase 1","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","RSK family","STE20 family","SGK family","Casein kinase 1 (CK1) family","D
eath-associated kinase (DAPK) family","CAMK-like (CAMKL) family","CAMK2 family","Protein kinase D (PKD) family","CAMK1 family","CLK family","DMPK family","TKL: Tyrosine kinase-like","Phosphorylase kin
ase (PHK) family","Protein kinase N (PKN) family","PDK1 family","Polo-like kinase (PLK) family","RSK subfamily","MSN subfamily","MST subfamily","Aurora kinase (Aur) family","MARK subfamily","p70 subfa
mily","KHS subfamily","CHK1 subfamily","BRSK subfamily","SLK subfamily","Rho kinase","Interleukin-1 receptor-associated kinase (IRAK) family","Janus kinase (JakA) family","Fer family","Tec family","Ty
pe II RTKs: Insulin receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Fak family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Neuronal System","Cell Cycle","Gene expression (Transcription)","DNA Repair","Immune System","Developmental Biology","Transport of small molecules","Signaling by Recept
or Tyrosine Kinases","Intracellular signaling by second messengers","Diseases of signal transduction by growth factor receptors and second messengers","Transmission across Chemical Synapses",Mitotic,"
RNA Polymerase II Transcription","DNA Double-Strand Break Repair","Signaling by GPCR","Innate Immune System","Infectious disease","Nervous system development","Plasma lipoprotein assembly",remodeling,
"and clearance","Adaptive Immune System","Signaling by VEGF","PIP3 activates AKT signaling","Signaling by PDGFR in disease","Signaling by FGFR in disease","Neurotransmitter receptors and postsynaptic 
signal transmission","Mitotic G1 phase and G1/S transition","Signaling by Insulin receptor","Signaling by NTRKs","Generic Transcription Pathway","Homology Directed Repair","Signaling by KIT in disease
","GPCR downstream signalling","GPCR ligand binding","M Phase","Toll-like Receptor Cascades","Leishmania infection","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Plasma lipoprotein
 clearance","Axon guidance","TCR signaling","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AKT network","Drug resistance of PDGFR mutants","Signaling by FG
FR1 in disease","Activation of NMDA receptors and postsynaptic events","G1/S Transition","Insulin receptor signalling cascade","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX1","HDR th
rough Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Transcriptional Regulation by TP53","Drug resistance of KIT mutants","G alpha (q) signalling events","Class A/1 (Rhodopsin-like 
receptors)","Mitotic Metaphase and Anaphase","Toll Like Receptor 5 (TLR5) Cascade","Parasite infection","Transcriptional Regulation by VENTX","LDL clearance","Leishmania parasite growth and survival",
"RET signaling","Generation of second messenger molecules","VEGFR2 mediated cell proliferation","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling",
"Imatinib-resistant PDGFR mutants","FGFR1 mutant receptor activation","Post NMDA receptor activation events","Activation of the pre-replicative complex","IRS-mediated signalling","Signalling to ERKs",
"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","HDR through Homologous Recombination (HRR)","Regulation of TP53 Activity","Dasatinib-resistant KIT mutants","Ga
strin-CREB signalling pathway via PKC and MAPK","Peptide ligand-binding receptors","Mitotic Anaphase","MyD88 cascade initiated on plasma membrane","Leishmania phagocytosis","Anti-inflammatory response
 favouring Leishmania parasite infection","Signaling by activated point mutants of FGFR1","Activation of AMPK downstream of NMDARs","PI3K Cascade","Signalling to RAS","Homologous DNA Pairing and Stran
d Exchange","Regulation of TP53 Expression and Degradation","EGFR Transactivation by Gastrin","Vasopressin-like receptors","Nuclear Envelope (NE) Reassembly","MAP kinase activation","FCGR3A-mediated p
hagocytosis","ADORA2B mediated anti-inflammatory cytokines production","p38MAPK events","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation","Initiation o
f Nuclear Envelope (NE) Reformation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated","Cellular responses to external stimuli",Metabolism,"Cellular resp
onses to stress","Signaling by Hippo","Ion channel transport","Cytokine Signaling in Immune system","MTOR signalling","Metabolism of lipids","Metabolism of carbohydrates","Signaling by Rho GTPases","M
itotic G2-G2/M phases","Cellular Senescence","Stimuli-sensing channels","Signaling by Interleukins","Signaling by SCF-KIT","Oncogenic MAPK signaling","mTORC1-mediated signalling","HIV Infection","Sphi
ngolipid metabolism","Interferon Signaling","Signaling by WNT in cancer","Glycogen metabolism","RHO GTPase Effectors","G2/M Transition","PTEN Regulation","Oxidative Stress Induced Senescence","G1 Phas
e","Interleukin-2 family signaling","Signaling by RAS mutants","Host Interactions of HIV factors","Sphingolipid de novo biosynthesis","Interferon alpha/beta signaling","Signaling by AMER1 mutants","Si
gnaling by NTRK3 (TRKC)","Semaphorin interactions","Toll Like Receptor 2 (TLR2) Cascade","Signaling by FGFR3 in disease","Glycogen breakdown (glycogenolysis)","RHO GTPases activate PKNs","Centrosome m
aturation","Regulation of PTEN stability and activity","Cyclin D associated events in G1","Interleukin-15 signaling","Signaling downstream of RAS mutants","The role of Nef in HIV-1 replication and dis
ease pathogenesis","Activation of TRKA receptors","Regulation of IFNA signaling","Truncations of AMER1 destabilize the destruction complex","Activated NTRK3 signals through PI3K","RUNX1 regulates tran
scription of genes involved in BCR signaling","Sema4D in semaphorin signaling","Toll Like Receptor TLR6:TLR2 Cascade","Signaling by FGFR3 point mutants in cancer","Interleukin-2 signaling","Loss of pr
oteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of R
AS signaling","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","NGF-independant TRKA activation","Separation of Sister Chromatids","Activation of RAC1 d
ownstream of NMDARs","Nef and signal transduction","FCGR3A-mediated IL10 synthesis","Prolonged ERK activation events","Sema4D induced cell migration and growth-cone collapse","MyD88:MAL(TIRAP) cascade
 initiated on plasma membrane","FGFR3 mutant receptor activation","Loss of Nlp from mitotic centrosomes","Ras activation upon Ca2+ influx through NMDA receptor","Nef Mediated CD4 Down-regulation","ARM
S-mediated activation","Signaling by activated point mutants of FGFR3","activated TAK1 mediates p38 MAPK activation","CREB phosphorylation"}

> <broad_targets>
{FGFR1,FLT1,KDR,KIT,PDGFRA,PDGFRB,RET}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{"3-((3,5-dimethyl-1H-pyrrol-2-yl)methylidene)-1H-indol-2-one","3((3,5dimethyl1Hpyrrol2yl)methylidene)1Hindol2one",194413-58-6,194413586,DSSTox_CID_21132,DSSToxCID21132,DSSTox-CID-21132,"DSSTox CID 21
132",DSSTox_RID_79631,DSSToxRID79631,DSSTox-RID-79631,"DSSTox RID 79631",DSSTox_GSID_41132,DSSToxGSID41132,DSSTox-GSID-41132,"DSSTox GSID 41132",CAS-204005-46-9,CAS204005469,"2H-Indol-2-one, 3-((3,5-d
imethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-","2HIndol2one, 3((3,5dimethyl1Hpyrrol2yl)methylene)1,3dihydro",NCGC00094381-03,NCGC0009438103,Kinome_2848,Kinome2848,Kinome-2848,"Kinome 2848",S,T2064,T2
496,"EMD 676487",3037,Semaxinib,Semaxanib,676487,"SU 5416"}

> <pdid>
PD002610

> <targets>
{VEGFR}

> <classes>
{}

> <pubchem_cids>
{123015}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    3.9266   -5.8778    0.0000 C   0  0
    4.8090   -4.6648    0.0000 C   0  0
    6.3007   -4.8230    0.0000 C   0  0
    5.4181   -6.0356    0.0000 C   0  0
    4.2013   -3.2954    0.0000 N   0  0
    2.7345   -2.9814    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9504   -0.8818    0.0000 C   0  0
    4.4160    0.5441    0.0000 C   0  0
    3.4139    1.6603    0.0000 N   0  0
    5.8837    0.8539    0.0000 N   0  0
    6.8858   -0.2623    0.0000 C   0  0
    6.4202   -1.6882    0.0000 N   0  0
    4.9525   -1.9980    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17  8  1  0
 17 12  1  0
  7 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24  5  1  0
 24 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28320

> <plate>
Kinase v5-1

> <well>
O10

> <supplier_cmpd_name>
1-Naphthyl PP1

> <ctcr_id>
5645

> <supplier_cmpd_id>
3063

> <smiles>
CC(C)(C)n1nc(c2cccc3ccccc23)c4c(N)ncnc14

> <pd_targets>
{RIPK2,FYN,SRC,CSK,MAPK8,PRKD1,ABL1,CDK2,PLD2,PLD1,CSNK1D,LCK,PRKCE,CDPK1,CAMK2A}

> <pathway_gtopdb>
{Enzyme,Kinase,Hydrolase,"Protein Kinase","TKL protein kinase group","TK protein kinase group","CMGC protein kinase group","CAMK protein kinase group","CK1 protein kinase group","AGC protein kinase gr
oup","TKL protein kinase RIPK family","Tyrosine protein kinase Src family","Tyrosine protein kinase Csk family","CMGC protein kinase MAPK family","CAMK protein kinase PKD family","Tyrosine protein kin
ase Abl family","CMGC protein kinase CDK family","CK1 protein kinase CK1 family","AGC protein kinase PKC family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase SrcA","CMGC protein kinase 
JNK subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase PKC eta subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Glycerophospholipid turnover","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent pr
otein kinases","Phosphatidylcholine-specific phospholipase D","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","Mitogen-activated prote
in kinases (MAP kinases)","Protein kinase D (PKD) family","Cyclin-dependent kinase (CDK) family","Casein kinase 1 (CK1) family","Protein kinase C (PKC) family","CAMK2 family","Receptor interacting pro
tein kinase (RIPK) family","Non-receptor tyrosine kinases (nRTKs)","JNK subfamily","CDK1 subfamily","Eta subfamily","Src family","Csk family","Abl family"}

> <pathway_reactome>
{"Immune System",Disease,"Signal Transduction",Metabolism,"Gene expression (Transcription)","Cell Cycle","Neuronal System","Innate Immune System","Infectious disease","Signaling by Receptor Tyrosine K
inases","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","RNA Polymerase II Transcription",Mitotic,"Transmission across Chemical Synapses","Tol
l-like Receptor Cascades","HIV Infection","Signaling by NTRKs","Oncogenic MAPK signaling","Sphingolipid metabolism","Leishmania infection","Generic Transcription Pathway","Phospholipid metabolism","Mi
totic G2-G2/M phases","Fcgamma receptor (FCGR) dependent phagocytosis","Neurotransmitter receptors and postsynaptic signal transmission","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV
 factors","Signaling by NTRK1 (TRKA)","Signaling by RAS mutants","Sphingolipid de novo biosynthesis","Parasite infection","Transcriptional Regulation by TP53","Glycerophospholipid biosynthesis","G2/M 
Transition","Role of phospholipids in phagocytosis","Activation of NMDA receptors and postsynaptic events","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and diseas
e pathogenesis","Signalling to ERKs","Signaling downstream of RAS mutants","Leishmania phagocytosis","Regulation of TP53 Activity","Synthesis of PA","Centrosome maturation","Post NMDA receptor activat
ion events","MAP kinase activation","Nef and signal transduction","Signalling to RAS","FCGR3A-mediated phagocytosis","Regulation of TP53 Expression and Degradation","Loss of proteins required for inte
rphase microtubule organization from the centrosome","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","CREB1 phosphorylation through NMDA receptor-media
ted activation of RAS signaling","activated TAK1 mediates p38 MAPK activation","p38MAPK events","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Loss of Nlp fro
m mitotic centrosomes","Nef Mediated CD4 Down-regulation","Ras activation upon Ca2+ influx through NMDA receptor","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{SRC}

> <broad_moa>
{"SRC inhibitor"}

> <synonyms>
{"NAPHTHYL PP",221243-82-9,221243829,"1-NAPHTHYL PP1","1NAPHTHYL PP1",1-NA-PP1,1NAPP1,"1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1(tertButyl)3(naphthalen1yl)1Hpyrazolo(3
,4d)pyrimidin4amine","pp1 analog","4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo(3,4-d)pyrimidine","4Amino1tertbutyl3(1'naphthyl)pyrazolo(3,4d)pyrimidine",CHEMBL264406,CHEBI:52310,1-tert-butyl-3-naphth
ale,1tertbutyl3naphthale,3063,"1-Naphthyl PP1"}

> <pdid>
PD012665

> <targets>
{"Src Kinases",Src}

> <classes>
{Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{4877}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
   -5.3864   -6.7681    0.0000 O   0  0
   -3.9462   -7.1872    0.0000 C   0  0
   -3.5894   -8.6441    0.0000 O   0  0
   -2.8628   -6.1485    0.0000 C   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 C   0  0
   -3.2175   -4.6910    0.0000 C   0  0
   -4.6578   -4.2692    0.0000 C   0  0
   -5.1442   -2.8637    0.0000 C   0  0
   -6.6435   -2.9101    0.0000 C   0  0
   -7.0627   -4.3503    0.0000 C   0  0
   -5.8226   -5.1941    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 10  1  0
  7 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 15  1  0
 23 18  1  0
 21 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28321

> <plate>
Kinase v5-1

> <well>
O12

> <supplier_cmpd_name>
GSK 650394

> <ctcr_id>
1169

> <supplier_cmpd_id>
3572

> <smiles>
OC(=O)c1ccc(cc1C2CCCC2)c3c[nH]c4ncc(cc34)c5ccccc5

> <pd_targets>
{CAMKK2,SGK2,SGK1,AURKA}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","AGC protein kinase group","Other protein kinase CAMKK family","AGC protein kinase SGK family","Other protein kinase AUR family","Other pro
tein kinase Meta subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","Other protein kinases","SGK family","CAMKK family","Aurora kinase (Aur) fam
ily","Meta subfamily"}

> <pathway_reactome>
{"Neuronal System","Transport of small molecules","Gene expression (Transcription)","Transmission across Chemical Synapses","Ion channel transport","RNA Polymerase II Transcription","Neurotransmitter 
receptors and postsynaptic signal transmission","Stimuli-sensing channels","Generic Transcription Pathway","Activation of NMDA receptors and postsynaptic events","Transcriptional Regulation by TP53","
Post NMDA receptor activation events","Regulation of TP53 Activity","Activation of AMPK downstream of NMDARs","Regulation of TP53 Expression and Degradation","Regulation of TP53 Activity through Phosp
horylation","Regulation of TP53 Degradation"}

> <broad_targets>
{SGK1,SGK2}

> <broad_moa>
{"serum/glucocorticoid regulated kinase inhibitor"}

> <synonyms>
{"GSK 650394",890842-28-1,890842281,GSK650394,GSK-650394,"2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)benzoic acid","2cyclopentyl4(5phenyl1Hpyrrolo(2,3b)pyridin3yl)benzoic acid",UNII-56887
611DJ,UNII56887611DJ,CHEMBL558642,56887611DJ,"2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)benzoic acid.","2cyclopentyl4(5phenyl1Hpyrrolo(2,3b)pyridin3yl)benzoic acid.",2-Cyclopenty,2Cyclop
enty,T2622,3572,nan}

> <pdid>
PD003278

> <targets>
{"Other Kinases","Glucocorticoid Regulated Kinsase (SGK) Inhibitor",SGK,"Influenza Virus"}

> <classes>
{Anti-infection,Metabolic Enzyme/Protease}

> <pubchem_cids>
{25022668}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 25  0  0  0  0            999 V2000
    4.8817   -2.5602    0.0000 O   0  0
    3.8794   -1.4442    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.8244   -5.7203    0.0000 C   0  0
    0.3359   -5.9054    0.0000 O   0  0
    2.8574   -6.8079    0.0000 N   0  0
    4.2102   -6.1617    0.0000 C   0  0
    5.5962   -6.7352    0.0000 C   0  0
    6.7859   -5.8216    0.0000 C   0  0
    8.1719   -6.3951    0.0000 Br  0  0
    6.5895   -4.3345    0.0000 C   0  0
    5.2035   -3.7610    0.0000 C   0  0
    4.0138   -4.6746    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9  4  1  0
  9 10  2  3
 10 11  1  0
 11  3  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 18 20  2  0
 20 21  1  0
 21 22  2  0
 22 12  1  0
 22 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28322

> <plate>
Kinase v5-1

> <well>
O14

> <supplier_cmpd_name>
BIO

> <ctcr_id>
8357

> <supplier_cmpd_id>
3194

> <smiles>
ONC/1=C2C=CC=CC2=NC1=C3/C(=O)Nc4cc(Br)ccc34

> <pd_targets>
{CDK1,CDK5}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","CDK5 subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Mitotic,"RNA Polymerase II Transcription","Regulation of mitotic cell cycle","Generic Transcription Pathway","APC/C-mediated degradation of cell cycle p
roteins","Transcriptional Regulation by TP53","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity","APC/C:Cdc20 mediated degradation of mitotic 
proteins","Regulation of TP53 Activity through Phosphorylation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated 
degradation of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{CHEMBL243555,667463-62-9,667463629,"667463 62 9",BIO,6-BROMOINDIRUBIN-3'-OXIME,6BROMOINDIRUBIN3'OXIME,"6 BROMOINDIRUBIN 3' OXIME","GSK-3 Inhibitor IX","GSK3 Inhibitor IX","GSK 3 Inhibitor IX",6BIO,6-
bromoindirubin-3-oxime,6bromoindirubin3oxime,6bromoindirubin3oxim,3194}

> <pdid>
PD039018

> <targets>
{}

> <classes>
{}

> <pubchem_cids>
{448949}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    3.9015    0.7475    0.0000 F   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    3.8919   -5.2525    0.0000 Cl  0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    3.9072    5.2405    0.0000 N   0  0
    3.9020    3.7405    0.0000 C   0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 11 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 19  1  0
 24 25  2  0
 25  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28323

> <plate>
Kinase v5-1

> <well>
O16

> <supplier_cmpd_name>
SD 208

> <ctcr_id>
757

> <supplier_cmpd_id>
3269

> <smiles>
Fc1ccc(Cl)cc1c2nc(Nc3ccncc3)c4nccnc4n2

> <pd_targets>
{TGFBR1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase STKR family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","Receptor serine/threonine kinase (RSTK) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by TGF-beta Receptor Complex in Cancer","Loss of Function of SMAD2/3 in Cancer","SMAD2/3 Phosphor
ylation Motif Mutants in Cancer"}

> <broad_targets>
{TGFBR1}

> <broad_moa>
{"TGF beta receptor inhibitor"}

> <synonyms>
{SD-208,SD208,627536-09-8,627536098,"SD 208",2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine,2(5chloro2fluorophenyl)N(pyridin4yl)pteridin4amine,2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylp
teridin-4-amine,2(5chloro2fluorophenyl)Npyridin4ylpteridin4amine,CHEMBL238125,MFCD11519969,2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl-amine,2(5Chloro2fluorophenyl)pteridin4yl)pyridin4ylamin
e,ALK5,T2109,3269}

> <pdid>
PD012771

> <targets>
{"TGF-beta Receptors","TGFbeta R1",TGFbR1,"TGF-² Receptor"}

> <classes>
{TGF-beta/Smad}

> <pubchem_cids>
{10316032}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -5.1961   -3.0000    0.0000 C   0  0
   -5.1962   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  2  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28324

> <plate>
Kinase v5-1

> <well>
O18

> <supplier_cmpd_name>
Compound 401

> <ctcr_id>
3616

> <supplier_cmpd_id>
3271

> <smiles>
O=C1C=C(N=C2N1C=Cc3ccccc23)N4CCOCC4

> <pd_targets>
{PRKDC,MTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Other PIKK family kinases","FRAP subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)","Innate Immune System","RNA Polymerase II Transcription","Cytosolic sensors of pathogen-associated DNA","Generic Transcription Pathway","STING mediat
ed induction of host immune responses","Transcriptional Regulation by TP53","IRF3-mediated induction of type I IFN","Regulation of TP53 Activity","Regulation of TP53 Expression and Degradation","Regul
ation of TP53 Degradation"}

> <broad_targets>
{MTOR,PRKDC}

> <broad_moa>
{"DNA dependent protein kinase inhibitor"}

> <synonyms>
{"Compound 401",168425-64-7,168425647,"2-morpholino-4H-pyrimido(2,1-a)isoquinolin-4-one","2morpholino4Hpyrimido(2,1a)isoquinolin4one","2-(morpholin-4-yl)pyrimido(2,1-a)isoquinolin-4-one","2(morpholin4
yl)pyrimido(2,1a)isoquinolin4one","2-(4-MORPHOLINYL)-4H-PYRIMIDO(2,1-A)ISOQUINOLIN-4-ONE","2(4MORPHOLINYL)4HPYRIMIDO(2,1A)ISOQUINOLIN4ONE",CHEMBL179242,4H-Pyrimido(2,4HPyrimido(2,1-a)isoquinolin-4-one
,1a)isoquinolin4one,2-(4-morph,2(4morph,T3586,3271,"EMD 234501",234501,"COMPOUND 401"}

> <pdid>
PD015722

> <targets>
{DNA-PK,"Compound 401"}

> <classes>
{}

> <pubchem_cids>
{10039361}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
   -0.4646   -9.3545    0.0000 O   0  5
    1.0278   -9.2037    0.0000 N   0  3
    1.9043  -10.4210    0.0000 O   0  0
    1.6423   -7.8372    0.0000 C   0  0
    0.8997   -6.5339    0.0000 S   0  0
    1.9143   -5.4464    0.0000 C   0  0
    1.6137   -3.9759    0.0000 S   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2566    0.5871    0.0000 O   0  0
    2.5987   -1.5004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.2766   -6.0429    0.0000 N   0  0
    3.1112   -7.5338    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13  8  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 17  1  0
 22 23  2  0
 23 14  1  0
  6 24  2  0
 24 25  1  0
 25  4  2  0
M  CHG  2   1  -1   2   1
M  END
> <name>
UTKinase_V5

> <id>
28325

> <plate>
Kinase v5-1

> <well>
O20

> <supplier_cmpd_name>
BI 78D3

> <ctcr_id>
44

> <supplier_cmpd_id>
3314

> <smiles>
[O-][N+](=O)c1sc(SC2=NNC(=O)N2c3ccc4OCCOc4c3)nc1

> <pd_targets>
{REP,MAPK9,MAPK8,MAPK10}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase JNK subfamily"}

> <pathway_chembl>
{"Other protein targets",Enzymes,"Anti-infective targets","Kinases (EC 2.7.x.x)","Viral protein targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Coronavirus (CoV) proteins","Mitogen-activated
 protein kinases (MAP kinases)","JNK subfamily"}

> <pathway_reactome>
{Disease,"Immune System","Infectious disease","Innate Immune System","SARS-CoV Infections","Toll-like Receptor Cascades","SARS-CoV-2 Infection","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-2 Genome
 Replication and Transcription","MyD88 cascade initiated on plasma membrane","Replication of the SARS-CoV-2 genome","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","Acti
vation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK8}

> <broad_moa>
{"JNK inhibitor"}

> <synonyms>
{BI-78D3,BI78D3,883065-90-5,883065905,"BI 78D3",CHEMBL508280,MLS006010634,SCHEMBL8187066,BDBM26057,CHEBI:94732,DTXSID10372629,EX-A970,EXA970,HMS3413H22,HMS3677H22,BCP17200,ANW-67494,ANW67494,BDBM50526
695,CCG-56351,CCG56351,MFCD01313575,s8201,ZINC12370057,AKOS016006596,CCG-268395,CCG268395,C,T6784,3314,nan,"JNK INHIBITOR X"}

> <pdid>
PD021753

> <targets>
{"MAPK Family",JNK}

> <classes>
{MAPK/ERK Pathway}

> <pubchem_cids>
{2747117}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 15  0  0  0  0            999 V2000
    1.0255   -3.6140    0.0000 N   0  0
    1.6332   -2.2426    0.0000 C   0  0
    3.1247   -2.0836    0.0000 O   0  0
    0.7500   -1.0323    0.0000 C   0  0
    1.2135    0.3943    0.0000 S   0  0
    0.0000    1.2760    0.0000 C   0  0
   -1.2135    0.3943    0.0000 C   0  0
   -0.7500   -1.0323    0.0000 C   0  0
   -1.6317   -2.2458    0.0000 N   0  0
    0.0000    2.7767    0.0000 C   0  0
    1.1393    3.7252    0.0000 C   0  0
    0.5656    5.1112    0.0000 S   0  0
   -0.9298    4.9939    0.0000 C   0  0
   -1.2803    3.5354    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  4  2  0
  8  9  1  0
  6 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28326

> <plate>
Kinase v5-1

> <well>
O22

> <supplier_cmpd_name>
SC 514

> <ctcr_id>
1461

> <supplier_cmpd_id>
3318

> <smiles>
NC(=O)c1sc(cc1N)c2cscc2

> <pd_targets>
{MAPT,IKBKB,ALDH1A1}

> <pathway_gtopdb>
{"Other cytosolic protein",Enzyme,Kinase,Oxidoreductase,"Protein Kinase","Other protein kinase group","Other protein kinase IKK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","IKK family"}

> <pathway_reactome>
{"Neuronal System","Immune System",Metabolism,"Transmission across Chemical Synapses","Innate Immune System","Biological oxidations","Neurotransmitter receptors and postsynaptic signal transmission","
Toll-like Receptor Cascades","Phase I - Functionalization of compounds","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 4 (TLR4) Cascade","Ethanol oxidation","Post NMDA rece
ptor activation events","MyD88-independent TLR4 cascade","Activation of AMPK downstream of NMDARs","TRIF(TICAM1)-mediated TLR4 signaling","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor","SYK inhibitor"}

> <synonyms>
{C51,SC-514,SC514,354812-17-2,354812172,"Sc 514","4-Amino-(2,3'-bithiophene)-5-carboxamide","4Amino(2,3'bithiophene)5carboxamide",3-amino-5-thiophen-3-ylthiophene-2-carboxamide,3amino5thiophen3ylthiop
hene2carboxamide,3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide,3amino5(thiophen3yl)thiophene2carboxamide,CHEMBL193093,3-amino-5-(3-thienyl)thiophene-2-carboxamide,3amino5(3thienyl)thiophene2carboxa
mide,3-amino-5-(3-thio,3amino5(3thio,T2118,3318,EI-343,S4907,"SC 514"}

> <pdid>
PD010663

> <targets>
{IKK,I??B/IKK,I?B/IKK,IKK2}

> <classes>
{NF-?B}

> <pubchem_cids>
{2807869}

$$$$
UTKinase_V5
  SciTegic11012413002D

 13 14  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Br  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 Br  0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Br  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Br  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11  7  1  0
 11 12  2  0
 12  2  1  0
 12 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28328

> <plate>
Kinase v5-1

> <well>
B06

> <supplier_cmpd_name>
TBB

> <ctcr_id>
1346

> <supplier_cmpd_id>
2275

> <smiles>
Brc1c(Br)c(Br)c2nn[nH]c2c1Br

> <pd_targets>
{CSNK2A1,CSNK2A2,CSNK2B,FTL,LMNA,KDM4E,ALOX15,HPGD,CYP3A4,DYRK1A,NQO2,REP,KMT2A,MEN1,THPO,NS3,GMNN,RECQL,NFKB1,ALDH1A1,BLM,CSNK2A3,MAPT,HSD17B10}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Other nuclear protein","Epigenetic regulator","Other cytosolic protein",Kinase,Eraser,Oxidoreductase,"Cytochrome P450",Transferase,Reader,Protease,"Protein Kinase","Lys
ine demethylase","Cytochrome P450 family 3",Bromodomain,"Serine protease","Other protein kinase group","Jumonji domain-containing","Cytochrome P450 family 3A","CMGC protein kinase group","Serine prote
ase PA clan","Other protein kinase CK2 family","Cytochrome P450 3A4","CMGC protein kinase DYRK family","Serine protease S29 family","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","Anti-infective targets","Receptor kinases
","1.14.11.- Histone demethylases",Lipoxygenases,"Prostaglandin synthases","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Viral protein targets","Other protein kinases","Dual-specifici
ty tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Coronavirus (CoV) proteins","Casein kinase 2 (CK2) family","Dyrk1 subfamily"}

> <pathway_reactome>
{"Vesicle-mediated transport","Gene expression (Transcription)","Cell Cycle",Metabolism,Disease,Hemostasis,"Immune System","DNA Repair","Neuronal System","Membrane Trafficking","RNA Polymerase II Tran
scription",Mitotic,"Metabolism of lipids","Biological oxidations","Infectious disease","Platelet activation","signaling and aggregation","Cytokine Signaling in Immune system","DNA Double-Strand Break 
Repair","Transmission across Chemical Synapses","Metabolism of amino acids and derivatives","trans-Golgi Network Vesicle Budding","Generic Transcription Pathway","M Phase","Biosynthesis of specialized
 proresolving mediators (SPMs)","Mitotic G1 phase and G1/S transition","Phase I - Functionalization of compounds","SARS-CoV Infections","Platelet Aggregation (Plug Formation)","Signaling by Interleuki
ns","Homology Directed Repair","Neurotransmitter receptors and postsynaptic signal transmission","Branched-chain amino acid catabolism","Golgi Associated Vesicle Biogenesis","Transcriptional Regulatio
n by TP53","Mitotic Metaphase and Anaphase","Biosynthesis of DPA-derived SPMs","Biosynthesis of DHA-derived SPMs","G0 and Early G1","SARS-CoV-2 Infection","G1/S Transition","Interleukin-1 family signa
ling","Ethanol oxidation","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Activation of NMDA receptors and postsynaptic events","Regulation of TP53 Activity","Mitotic An
aphase","Biosynthesis of DPAn-3 SPMs","Biosynthesis of D-series resolvins","Biosynthesis of maresins","SARS-CoV-2 Genome Replication and Transcription","Activation of the pre-replicative complex","Int
erleukin-1 signaling","HDR through Homologous Recombination (HRR)","Post NMDA receptor activation events","Regulation of TP53 Activity through Phosphorylation","Nuclear Envelope (NE) Reassembly","Bios
ynthesis of DPAn-3-derived protectins and resolvins","Biosynthesis of maresin-like SPMs","Replication of the SARS-CoV-2 genome","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Homologous DNA Pairing and
 Strand Exchange","Activation of AMPK downstream of NMDARs","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{17374-26-4,17374264,"4,5,6,7-tetrabromobenzotriazole","4,5,6,7tetrabromobenzotriazole",TBB,"4,5,6,7-Tetrabromo-1H-benzotriazole","4,5,6,7Tetrabromo1Hbenzotriazole",TBBt,"4,5,6,7-tetrabromo-2H-benzotr
iazole","4,5,6,7tetrabromo2Hbenzotriazole","4,5,6,7-Tetrabromo-1H-benzo(d)(1,2,3)triazole","4,5,6,7Tetrabromo1Hbenzo(d)(1,2,3)triazole",TETRABROMO-2-BENZOTRIAZOLE,TETRABROMO2BENZOTRIAZOLE,"4,5,6,7-Tet
rabromo-2-azabenzimidazole","4,5,6,7Tetrabromo2azabenzimidazole",Ca,2275,"EMD 218697",218697}

> <pdid>
PD002647

> <targets>
{"Casein Kinase II Inhibitor I",CK2}

> <classes>
{}

> <pubchem_cids>
{1694}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
    4.9531   -1.9978    0.0000 N   0  0
    4.2010   -3.2956    0.0000 N   0  0
    2.7343   -2.9815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  1  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  4 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 12  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28329

> <plate>
Kinase v5-1

> <well>
B08

> <supplier_cmpd_name>
LY 364947

> <ctcr_id>
11450

> <supplier_cmpd_id>
2718

> <smiles>
[nH]1ncc(c1c1ccccn1)c1ccnc2ccccc12

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Y36494,396129-53-6,396129536,LY-364947,LY364947,4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)quinoline,4(3(pyridin2yl)1Hpyrazol4yl)quinoline,4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE,4(3PYRIDIN2YL1HPYRAZOL4
YL)QUINOLINE,"TGF-beta RI Kinase Inhibitor","TGFbeta RI Kinase Inhibitor","HTS 466284","TbetaR-I Inhibitor","TbetaRI Inhibitor","LY 364947",HTS-466284,HTS466284,CHEMBL261454,4-(3-pyridin-2-yl)(1h),4(3
pyridin2yl)(1h),T2048}

> <pdid>

> <targets>
{CK1¦Ä,MLK-7K,TGF¦ÂRI,TGF¦ÂRII,RIPK2}

> <classes>
{Metabolism,Apoptosis,MAPK,"Stem Cells"}

> <pubchem_cids>
{447966}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 20  0  0  0  0            999 V2000
    2.4192   -8.3243    0.0000 C   0  0
    1.2028   -7.4466    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6079   -6.7003    0.0000 C   0  0
   -0.2222   -7.9149    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  2  0
 16 17  1  0
 16 18  1  0
 18  2  2  0
M  END
> <name>
UTKinase_V5

> <id>
28330

> <plate>
Kinase v5-1

> <well>
B10

> <supplier_cmpd_name>
SU 5416

> <ctcr_id>
1850

> <supplier_cmpd_id>
3037

> <smiles>
Cc1[nH]c(C=C2C(=O)Nc3ccccc23)c(C)c1

> <pd_targets>
{KDR,FLT1,PDGFRB,ALK,FLT4,PDGFRA,FGFR1,MAPT,KMT2A,MEN1,GMNN,FLT3,SRC,BLM,USP2,KIT,EGFR,AVPR1A,LMNA,MAPK1,FGFR2,FGFR3,FGFR4,ABL1,CSF1R,PMP22,FFP,RECQL,NPC1,NPSR1,OXTR,MTOR,RET,ZAP70,PLK4,FRK,RPS6KA3,MA
P4K4,JAK2,STK3,SGK2,AURKA,CSNK1D,JAK3,FER,STK17A,MARK3,ITK,INSR,CAMK2D,RPS6KB1,LCK,CAMK2B,NTRK2,MAP4K5,CSNK1G2,AURKB,TYK2,CSNK1A1,PRKD3,CHEK2,MARK2,CAMK1,FYN,CLK2,AXL,NTRK3,BRSK1,PRKD2,SLK,LYN,NTRK1,M
INK1,BLK,ROCK1,IRAK4,CLK4,SYK,CAMK2G,CSNK1G3,PHKG2,IRAK1,MAP4K2,PTK2B,PKN2,PDPK1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator","Unclassified protein","Membrane receptor","Other nuclear protein",Transporter,Kinase,Reader,Protease,"Family A G protein-coupled receptor",Tra
nsferase,"Protein Kinase",Bromodomain,"Cysteine protease","Peptide receptor (family A GPCR)","TK protein kinase group","TKL protein kinase group","Cysteine protease CA clan","Short peptide receptor (f
amily A GPCR)","CMGC protein kinase group","Atypical protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","TKL protein kinase STKR family","Tyrosine prot
ein kinase FGFR family","Tyrosine protein kinase Src family","Cysteine protease C19 family","Tyrosine protein kinase EGFR family","Vasopressin and oxytocin receptor","CMGC protein kinase MAPK family",
"Tyrosine protein kinase Abl family","Cysteine protease C1A family","Neuropeptide receptor","Atypical protein kinase PIKK family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Syk fami
ly","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","Other protein kinase group","AGC protein kinase group","STE protein kinase group","C
K1 protein kinase group","CAMK protein kinase group","Other protein kinase PLK family","AGC protein kinase RSK family","STE protein kinase STE20 family","Tyrosine protein kinase JakA family","AGC prot
ein kinase SGK family","Other protein kinase AUR family","CK1 protein kinase CK1 family","Tyrosine protein kinase Fer family","CAMK protein kinase DAPK family","CAMK protein kinase CAMK1 family","Tyro
sine protein kinase Tec family","Tyrosine protein kinase InsR family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Trk family","CAMK protein kinase PKD family","CAMK protein kinase RAD5
3 family","CMGC protein kinase CLK family","Tyrosine protein kinase Axl family","AGC protein kinase DMPK family","TKL protein kinase IRAK family","CAMK protein kinase PHk family","Tyrosine protein kin
ase Fak family","AGC protein kinase PKN family","AGC protein kinase PDK1 subfamily","AGC protein kinase RSK subfamily","STE protein kinase MSN subfamily","STE protein kinase MST subfamily","CAMK prote
in kinase MARK subfamily","AGC protein kinase p70 subfamily","STE protein kinase KHS subfamily","Tyrosine protein kinase SrcA","CAMK protein kinase BRSK subfamily","STE protein kinase SLK subfamily","
AGC protein kinase ROCK subfamily","CK1 protein kinase CK1-g"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Catalytic receptors","Chromatin modifying enzymes","Peptidases and proteinases","G protein-coupled receptors","Kinases (EC 2.7.x.x)","SLC superfamily of solute carrier
s","Receptor kinases","2.1.1.43 Histone methyltransferases (HMTs)","CA: Cysteine (C) Peptidases","Vasopressin and oxytocin receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","SLC65 NPC-type ch
olesterol transporters","Neuropeptide S receptor",Atypical,"TK: Tyrosine kinase","C19: Ubiquitin-specific protease","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-r
elated kinases (PIKK) family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","FRAP subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) recep
tor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Src f
amily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Abl family","Type XIV RTKs: RET","Syk family","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile
 11","Sterile 20 kinases","CK1: Casein kinase 1","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","RSK family","STE20 family","SGK family","Casein kinase 1 (CK1) family","D
eath-associated kinase (DAPK) family","CAMK-like (CAMKL) family","CAMK2 family","Protein kinase D (PKD) family","CAMK1 family","CLK family","DMPK family","TKL: Tyrosine kinase-like","Phosphorylase kin
ase (PHK) family","Protein kinase N (PKN) family","PDK1 family","Polo-like kinase (PLK) family","RSK subfamily","MSN subfamily","MST subfamily","Aurora kinase (Aur) family","MARK subfamily","p70 subfa
mily","KHS subfamily","CHK1 subfamily","BRSK subfamily","SLK subfamily","Rho kinase","Interleukin-1 receptor-associated kinase (IRAK) family","Janus kinase (JakA) family","Fer family","Tec family","Ty
pe II RTKs: Insulin receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Fak family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Neuronal System","Cell Cycle","Gene expression (Transcription)","DNA Repair","Immune System","Developmental Biology","Transport of small molecules","Signaling by Recept
or Tyrosine Kinases","Intracellular signaling by second messengers","Diseases of signal transduction by growth factor receptors and second messengers","Transmission across Chemical Synapses",Mitotic,"
RNA Polymerase II Transcription","DNA Double-Strand Break Repair","Signaling by GPCR","Innate Immune System","Infectious disease","Nervous system development","Plasma lipoprotein assembly",remodeling,
"and clearance","Adaptive Immune System","Signaling by VEGF","PIP3 activates AKT signaling","Signaling by PDGFR in disease","Signaling by FGFR in disease","Neurotransmitter receptors and postsynaptic 
signal transmission","Mitotic G1 phase and G1/S transition","Signaling by Insulin receptor","Signaling by NTRKs","Generic Transcription Pathway","Homology Directed Repair","Signaling by KIT in disease
","GPCR downstream signalling","GPCR ligand binding","M Phase","Toll-like Receptor Cascades","Leishmania infection","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Plasma lipoprotein
 clearance","Axon guidance","TCR signaling","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AKT network","Drug resistance of PDGFR mutants","Signaling by FG
FR1 in disease","Activation of NMDA receptors and postsynaptic events","G1/S Transition","Insulin receptor signalling cascade","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX1","HDR th
rough Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Transcriptional Regulation by TP53","Drug resistance of KIT mutants","G alpha (q) signalling events","Class A/1 (Rhodopsin-like 
receptors)","Mitotic Metaphase and Anaphase","Toll Like Receptor 5 (TLR5) Cascade","Parasite infection","Transcriptional Regulation by VENTX","LDL clearance","Leishmania parasite growth and survival",
"RET signaling","Generation of second messenger molecules","VEGFR2 mediated cell proliferation","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling",
"Imatinib-resistant PDGFR mutants","FGFR1 mutant receptor activation","Post NMDA receptor activation events","Activation of the pre-replicative complex","IRS-mediated signalling","Signalling to ERKs",
"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","HDR through Homologous Recombination (HRR)","Regulation of TP53 Activity","Dasatinib-resistant KIT mutants","Ga
strin-CREB signalling pathway via PKC and MAPK","Peptide ligand-binding receptors","Mitotic Anaphase","MyD88 cascade initiated on plasma membrane","Leishmania phagocytosis","Anti-inflammatory response
 favouring Leishmania parasite infection","Signaling by activated point mutants of FGFR1","Activation of AMPK downstream of NMDARs","PI3K Cascade","Signalling to RAS","Homologous DNA Pairing and Stran
d Exchange","Regulation of TP53 Expression and Degradation","EGFR Transactivation by Gastrin","Vasopressin-like receptors","Nuclear Envelope (NE) Reassembly","MAP kinase activation","FCGR3A-mediated p
hagocytosis","ADORA2B mediated anti-inflammatory cytokines production","p38MAPK events","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation","Initiation o
f Nuclear Envelope (NE) Reformation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated","Cellular responses to external stimuli",Metabolism,"Cellular resp
onses to stress","Signaling by Hippo","Ion channel transport","Cytokine Signaling in Immune system","MTOR signalling","Metabolism of lipids","Metabolism of carbohydrates","Signaling by Rho GTPases","M
itotic G2-G2/M phases","Cellular Senescence","Stimuli-sensing channels","Signaling by Interleukins","Signaling by SCF-KIT","Oncogenic MAPK signaling","mTORC1-mediated signalling","HIV Infection","Sphi
ngolipid metabolism","Interferon Signaling","Signaling by WNT in cancer","Glycogen metabolism","RHO GTPase Effectors","G2/M Transition","PTEN Regulation","Oxidative Stress Induced Senescence","G1 Phas
e","Interleukin-2 family signaling","Signaling by RAS mutants","Host Interactions of HIV factors","Sphingolipid de novo biosynthesis","Interferon alpha/beta signaling","Signaling by AMER1 mutants","Si
gnaling by NTRK3 (TRKC)","Semaphorin interactions","Toll Like Receptor 2 (TLR2) Cascade","Signaling by FGFR3 in disease","Glycogen breakdown (glycogenolysis)","RHO GTPases activate PKNs","Centrosome m
aturation","Regulation of PTEN stability and activity","Cyclin D associated events in G1","Interleukin-15 signaling","Signaling downstream of RAS mutants","The role of Nef in HIV-1 replication and dis
ease pathogenesis","Activation of TRKA receptors","Regulation of IFNA signaling","Truncations of AMER1 destabilize the destruction complex","Activated NTRK3 signals through PI3K","RUNX1 regulates tran
scription of genes involved in BCR signaling","Sema4D in semaphorin signaling","Toll Like Receptor TLR6:TLR2 Cascade","Signaling by FGFR3 point mutants in cancer","Interleukin-2 signaling","Loss of pr
oteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of R
AS signaling","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","NGF-independant TRKA activation","Separation of Sister Chromatids","Activation of RAC1 d
ownstream of NMDARs","Nef and signal transduction","FCGR3A-mediated IL10 synthesis","Prolonged ERK activation events","Sema4D induced cell migration and growth-cone collapse","MyD88:MAL(TIRAP) cascade
 initiated on plasma membrane","FGFR3 mutant receptor activation","Loss of Nlp from mitotic centrosomes","Ras activation upon Ca2+ influx through NMDA receptor","Nef Mediated CD4 Down-regulation","ARM
S-mediated activation","Signaling by activated point mutants of FGFR3","activated TAK1 mediates p38 MAPK activation","CREB phosphorylation"}

> <broad_targets>
{FGFR1,FLT1,KDR,KIT,PDGFRA,PDGFRB,RET}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{"3-((3,5-dimethyl-1H-pyrrol-2-yl)methylidene)-1H-indol-2-one","3((3,5dimethyl1Hpyrrol2yl)methylidene)1Hindol2one",194413-58-6,194413586,DSSTox_CID_21132,DSSToxCID21132,DSSTox-CID-21132,"DSSTox CID 21
132",DSSTox_RID_79631,DSSToxRID79631,DSSTox-RID-79631,"DSSTox RID 79631",DSSTox_GSID_41132,DSSToxGSID41132,DSSTox-GSID-41132,"DSSTox GSID 41132",CAS-204005-46-9,CAS204005469,"2H-Indol-2-one, 3-((3,5-d
imethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-","2HIndol2one, 3((3,5dimethyl1Hpyrrol2yl)methylene)1,3dihydro",NCGC00094381-03,NCGC0009438103,Kinome_2848,Kinome2848,Kinome-2848,"Kinome 2848",S,T2064,T2
496,"EMD 676487",3037,Semaxinib,Semaxanib,676487,"SU 5416"}

> <pdid>
PD002610

> <targets>
{VEGFR}

> <classes>
{}

> <pubchem_cids>
{123015}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 47  0  0  0  0            999 V2000
    4.9573   -8.7775    0.0000 C   0  0
    4.4162   -7.3785    0.0000 O   0  0
    2.9334   -7.1466    0.0000 C   0  0
    1.9941   -8.3161    0.0000 C   0  0
    0.5116   -8.0874    0.0000 C   0  0
   -0.0316   -6.6892    0.0000 C   0  0
    0.9077   -5.5197    0.0000 C   0  0
    2.3903   -5.7483    0.0000 C   0  0
    3.3277   -4.5763    0.0000 N   0  0
    2.7822   -3.1780    0.0000 C   0  0
    3.7175   -2.0053    0.0000 N   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 N   0  0
    2.5242    2.0130    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
    0.0000    3.2286    0.0000 O   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.4523    2.0983    0.0000 C   0  0
   -3.8856    1.6561    0.0000 C   0  0
   -4.2194    0.1937    0.0000 C   0  0
   -3.1198   -0.8265    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 N   0  0
   -1.4008   -2.9088    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 N   0  0
   -0.4306   -9.2556    0.0000 C   0  0
    0.1101  -10.6547    0.0000 O   0  0
   -1.9135   -9.0247    0.0000 N   0  0
   -2.8570  -10.1909    0.0000 C   0  0
   -4.3386   -9.9571    0.0000 C   0  0
   -4.8770   -8.5570    0.0000 C   0  0
   -3.9336   -7.3908    0.0000 C   0  0
   -2.4520   -7.6246    0.0000 C   0  0
   -6.3594   -8.3231    0.0000 N   0  0
   -7.3047   -9.4878    0.0000 C   0  0
   -8.7860   -9.2516    0.0000 C   0  0
   -9.3221   -7.8507    0.0000 N   0  0
  -10.8034   -7.6145    0.0000 C   0  0
   -8.3769   -6.6860    0.0000 C   0  0
   -6.8956   -6.9221    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 14 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 26 13  1  0
 26 27  2  0
 27 10  1  0
  5 28  1  0
 28 29  2  0
 28 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 30  1  0
 33 36  1  0
 36 37  1  0
 37 38  1  0
 38 39  1  0
 39 40  1  0
 39 41  1  0
 41 42  1  0
 42 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28331

> <plate>
Kinase v5-1

> <well>
B12

> <supplier_cmpd_name>
LRRK2-IN-1

> <ctcr_id>
8329

> <supplier_cmpd_id>
4273

> <smiles>
COc1cc(ccc1Nc2ncc3N(C)C(=O)c4ccccc4N(C)c3n2)C(=O)N5CCC(CC5)N6CCN(C)CC6

> <pd_targets>
{LRRK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase LRRK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","Leucine-rich repeat kinase (LRRK) family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Non-Receptor Tyrosine Kinases","Signaling by PTK6","PTK6 promotes HIF1A stabilization"}

> <broad_targets>
{LRRK2}

> <broad_moa>
{"leucine rich repeat kinase inhibitor"}

> <synonyms>
{RRK2IN,LRRK2-IN-1,LRRK2IN1,1234480-84-2,1234480842,LRRK-2IN1,LRRK2-IN1,CHEMBL2012582,CHEBI:78413,4K4,"LRRK2-IN 1","LRRK2IN 1",LRRK2-TN-1,LRRK2TN1,MLS003230940,SCHEMBL616761,GTPL9396,DTXSID70676751,EX
-A644,EXA644,C31H38N8O3,HMS3265O17,HMS3265O18,HMS3265P17,HMS3265P18,BCP14860,3787AH,ABP0010,T2246,4273}

> <pdid>
PD003580

> <targets>
{"RIP kinase family"}

> <classes>
{}

> <pubchem_cids>
{46843906}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    4.9573   -8.7775    0.0000 C   0  0
    4.4162   -7.3785    0.0000 O   0  0
    2.9334   -7.1466    0.0000 C   0  0
    1.9941   -8.3161    0.0000 C   0  0
    0.5116   -8.0874    0.0000 C   0  0
   -0.0316   -6.6892    0.0000 C   0  0
    0.9077   -5.5197    0.0000 C   0  0
    2.3903   -5.7483    0.0000 C   0  0
    3.3277   -4.5763    0.0000 N   0  0
    2.7822   -3.1780    0.0000 C   0  0
    3.7175   -2.0053    0.0000 N   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 N   0  0
    2.5242    2.0130    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
    0.0000    3.2286    0.0000 O   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.4523    2.0983    0.0000 C   0  0
   -3.8856    1.6561    0.0000 C   0  0
   -4.2194    0.1937    0.0000 C   0  0
   -3.1198   -0.8265    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 N   0  0
   -1.4008   -2.9088    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 N   0  0
   -0.4281   -9.2575    0.0000 N   0  0
    0.1128  -10.6566    0.0000 C   0  0
   -0.8284  -11.8246    0.0000 C   0  0
   -2.3105  -11.5936    0.0000 N   0  0
   -3.2516  -12.7616    0.0000 C   0  0
   -2.8514  -10.1945    0.0000 C   0  0
   -1.9103   -9.0265    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 14 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 26 13  1  0
 26 27  2  0
 27 10  1  0
  5 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 31 33  1  0
 33 34  1  0
 34 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28333

> <plate>
Kinase v5-1

> <well>
B16

> <supplier_cmpd_name>
ERK5-IN-1

> <ctcr_id>
12518

> <supplier_cmpd_id>
5393

> <smiles>
COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1

> <pd_targets>
{DCLK2,TNK1,DCLK1,GAK,MAPK7,TNK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","TK protein kinase group","Other protein kinase group","CMGC protein kinase group","CAMK protein kinase DCAMK1 family","Tyrosine protein kin
ase Ack family","Other protein kinase NAK family","CMGC protein kinase MAPK family","CMGC protein kinase ERK5"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","DCAMKL family",
"TK: Tyrosine kinase","Other protein kinases","Mitogen-activated protein kinases (MAP kinases)","Non-receptor tyrosine kinases (nRTKs)","Numb-associated kinase (NAK) family","ERK subfamily","Ack famil
y"}

> <pathway_reactome>
{"Vesicle-mediated transport","Immune System","Membrane Trafficking","Innate Immune System","trans-Golgi Network Vesicle Budding","Toll-like Receptor Cascades","Golgi Associated Vesicle Biogenesis","T
oll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated
"}

> <broad_targets>
{MAPK7}

> <broad_moa>
{"MAP kinase inhibitor"}

> <synonyms>
{RK5IN,ERK5-IN-1,ERK5IN1,1234479-76-5,1234479765,XMD8-85,XMD885,CHEMBL1673039,SCHEMBL618262,CHEBI:91375,HMS3295A11,BCP19788,EX-A3073,EXA3073,BDBM50337127,ZB1553,ZINC66066276,"ERK5-IN-1  XMD 8-85","ERK
5IN1  XMD 885",ACN-034734,ACN034734,CS-4938,CS4938,"XMD17-109 (ERK5-IN-1)","XMD17109 (ERK5IN1)",BS-14786,BS14786,HY-14403,HY14403,A16232,BRD-K64857848-001-01-5,BRDK64857848001015,T5184}

> <pdid>
PD038823

> <targets>
{ERK5}

> <classes>
{MAPK}

> <pubchem_cids>
{46844147}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 45  0  0  0  0            999 V2000
   11.8956   -5.2421    0.0000 Cl  0  0
    9.0422   -6.3335    0.0000 C   0  0
    7.5507   -6.4932    0.0000 N   0  0
    6.8031   -7.7936    0.0000 N   0  0
    5.3353   -7.4845    0.0000 C   0  0
    4.2165   -8.4837    0.0000 O   0  0
    5.1946   -6.0039    0.0000 C   0  0
    6.5449   -5.3803    0.0000 C   0  0
    6.8454   -3.9100    0.0000 C   0  0
    5.8083   -2.8335    0.0000 C   0  0
    6.2245   -1.3923    0.0000 C   0  0
    7.6806   -1.0321    0.0000 C   0  0
    8.7206   -2.1131    0.0000 C   0  0
    8.3045   -3.5542    0.0000 C   0  0
    3.8950   -5.2533    0.0000 C   0  0
    2.5961   -6.0035    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    3.9015    0.7475    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2963   -3.7484    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    7.4161   -9.1635    0.0000 C   0  0
    8.8877   -9.4275    0.0000 C   0  0
    9.3956  -10.8389    0.0000 C   0  0
    8.4273  -11.9845    0.0000 C   0  0
    6.9510  -11.7187    0.0000 C   0  0
    6.4431  -10.3073    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  2  3
  8  3  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
  7 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 22 23  2  0
 23 17  1  0
 23 24  1  0
 22 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 30 32  1  0
 32 33  2  0
 33 34  1  0
 34 28  1  0
 34 35  2  0
 35 25  1  0
  4 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 39 40  1  0
 40 41  2  0
 41 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28335

> <plate>
Kinase v5-1

> <well>
B20

> <supplier_cmpd_name>
AMG PERK 44

> <ctcr_id>
14833

> <supplier_cmpd_id>
5517

> <smiles>
Cl.CN1N(C(=O)C(=C1c2ccccc2)C(=O)c3ccc(C)c(c3N)c4ccc5nc(C)ccc5c4)c6ccccc6

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HY-12661A,"AMG PERK 44","AMG PERK 44"}

> <pdid>
PD069643

> <targets>
{PERK,Autophagy}

> <classes>
{Autophagy,Cell Cycle/DNA Damage}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    7.8010   -2.9850    0.0000 C   0  0
    7.7980   -1.4850    0.0000 O   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8994   -3.7478    0.0000 O   0  0
   -5.1973   -2.9959    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 O   0  0
    0.0042   -5.9990    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    7.7876    1.5211    0.0000 N   0  0
    7.7802    3.0220    0.0000 C   0  0
    6.4773    3.7652    0.0000 O   0  0
    9.0758    3.7795    0.0000 N   0  0
    9.0685    5.2803    0.0000 C   0  0
    7.7656    6.0236    0.0000 C   0  0
   10.3641    6.0379    0.0000 C   0  0
   10.4968    7.5192    0.0000 S   0  0
   11.9630    7.8362    0.0000 C   0  0
   12.7175    6.5397    0.0000 C   0  0
   11.7176    5.4216    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 13 16  2  0
 16 17  1  0
 17 18  1  0
 16 19  1  0
 19 20  2  0
 20  7  1  0
 20 11  1  0
  5 21  2  0
 21 22  1  0
 22 23  2  0
 23  3  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 25 27  1  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 30  2  0
M  END
> <name>
UTKinase_V5

> <id>
28337

> <plate>
Kinase v5-1

> <well>
D04

> <supplier_cmpd_name>
Ki 20227

> <ctcr_id>
277

> <supplier_cmpd_id>
4481

> <smiles>
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c4sccn4

> <pd_targets>
{BLK,MAP2K2,ABL2,YES1,PTK6,TESK1,FRK,MST1R,ABL1,EPHA1,IRAK3,HIPK4,BMPR1B,CSNK1E,TNK2,ERBB4,FLT1,FLT4,FLT3,MERTK,MET,MAP4K5,RET,MAP3K20,LCK,TNIK,LYN,HCK,PDGFRB,KIT,CDPK1,EGFR,SRC,PDGFRA,NLK,SRMS,MINK1,
AXL,KDR,MAP2K1,TGFBR2,CSK,CSF1R,EPHA8,MAP3K19,MAP2K5,DDR1,RIPK2,AURKC,BTK,NEK11,GAK,STK4,TYRO3,PLK4,SLK,DDR2,AURKB,FYN,FGR,LIMK2,STK10,AURKA,EPHB6}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","TK protein kinase group","STE protein kinase group","TKL protein kinase group","CMGC protein kinase group","CK1 protein kinase group","Other pro
tein kinase group","Tyrosine protein kinase Src family","STE protein kinase STE7 family","Tyrosine protein kinase Abl family","TKL protein kinase LISK family","Tyrosine protein kinase Met family","Tyr
osine protein kinase Eph family","TKL protein kinase IRAK family","CMGC protein kinase DYRK family","TKL protein kinase STKR family","CK1 protein kinase CK1 family","Tyrosine protein kinase Ack family
","Tyrosine protein kinase EGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Axl family","STE protein kinase STE20 family","Tyrosine p
rotein kinase Ret family","TKL protein kinase MLK family","CMGC protein kinase MAPK family","Tyrosine protein kinase Csk family","STE protein kinase STE11 family","Tyrosine protein kinase DDR family",
"TKL protein kinase RIPK family","Other protein kinase AUR family","Tyrosine protein kinase Tec family","Other protein kinase NEK family","Other protein kinase NAK family","Other protein kinase PLK fa
mily","TKL protein kinase TESK subfamily","CMGC protein kinase HIPK subfamily","TKL protein kinase STKR Type 1 subfamily","STE protein kinase KHS subfamily","TKL protein kinase MLK subfamily","STE pro
tein kinase MSN subfamily","CMGC protein kinase nmo subfamily","Tyrosine protein kinase Srm","TKL protein kinase STKR Type 2 subfamily","Other protein kinase Nek11","STE protein kinase MST subfamily",
"STE protein kinase SLK subfamily","Tyrosine protein kinase SrcA","TKL protein kinase LIMK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families",
"CK1: Casein kinase 1","TK: Tyrosine kinase","STE7 family","TKL: Tyrosine kinase-like","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Casein kinase 1 (CK1) family","ST
E20 family","Mitogen-activated protein kinases (MAP kinases)","Other protein kinases","Non-receptor tyrosine kinases (nRTKs)","LIM domain kinase (LISK) family","Receptor tyrosine kinases (RTKs)","Inte
rleukin-1 receptor-associated kinase (IRAK) family","HIPK subfamily","Receptor serine/threonine kinase (RSTK) family","KHS subfamily","Mixed Lineage Kinase (MLK) family","MSN subfamily","nmo subfamily
","STE20 subfamily","Receptor interacting protein kinase (RIPK) family","Aurora kinase (Aur) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","Numb-associated kinase (NAK) family"
,"MST subfamily","Polo-like kinase (PLK) family","SLK subfamily","Src family","Abl family","TESK subfamily","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIII RTKs: Ephrin recept
or family","Type I receptor serine/threonine kinases","Ack family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor famil
y","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type XIV RTKs: RET","MLK subfamily","Type II receptor serine/threonine kinases
","Csk family","Type XVI RTKs: DDR (collagen receptor) family","Tec family","LIMK subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Developmental Biology",Disease,"Cell Cycle","Cell-Cell communication","Immune System","Neuronal System",Hemostasis,"Cellular responses to exte
rnal stimuli","Extracellular matrix organization","Vesicle-mediated transport","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Nervous system development","Infectious disea
se",Mitotic,"Cell junction organization","Intracellular signaling by second messengers","Innate Immune System","Signaling by TGFB family members","Transmission across Chemical Synapses","Cell surface 
interactions at the vascular wall","Cellular responses to stress","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by GPCR","Signaling by WNT","Signaling b
y Non-Receptor Tyrosine Kinases","Non-integrin membrane-ECM interactions","Membrane Trafficking","Signaling by Hippo","Generic Transcription Pathway","Signaling by NTRKs","Axon guidance","Leishmania i
nfection","Mitotic G1 phase and G1/S transition","Cell-extracellular matrix interactions","PIP3 activates AKT signaling","Signaling by MST1","Toll-like Receptor Cascades","Signaling by BMP","Mitotic G
2-G2/M phases","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by VEGF","Signaling by Insulin receptor","HIV Infection","Cellular Senescence","Signaling by KIT in disease"
,"GPCR downstream signalling","Signaling by PDGFR in disease","Beta-catenin independent WNT signaling","Signaling by PTK6","Signaling by TGF-beta Receptor Complex in Cancer","Oncogenic MAPK signaling"
,"trans-Golgi Network Vesicle Budding","M Phase","Neutrophil degranulation","Transcriptional regulation by RUNX1","Signaling by NTRK1 (TRKA)","Signaling by ROBO receptors","Leishmania parasite growth 
and survival","G1 Phase","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","PTEN Regulation","Parasite infection","EPH-Ephrin signaling","Toll Like Receptor 2 (TLR2)
 Cascade","G2/M Transition","Activation of NMDA receptors and postsynaptic events","VEGF ligand-receptor interactions","Insulin receptor signalling cascade","Semaphorin interactions","RET signaling","
Host Interactions of HIV factors","Oxidative Stress Induced Senescence","Negative regulation of the PI3K/AKT network","Drug resistance of KIT mutants","G alpha (q) signalling events","Drug resistance 
of PDGFR mutants","Ca2+ pathway","PTK6 Down-Regulation","VEGFA-VEGFR2 Pathway","Loss of Function of SMAD2/3 in Cancer","Signaling by RAS mutants","Transcriptional Regulation by VENTX","Toll Like Recep
tor 5 (TLR5) Cascade","Golgi Associated Vesicle Biogenesis","Mitotic Metaphase and Anaphase","Transcriptional Regulation by TP53","RUNX1 regulates transcription of genes involved in BCR signaling","Si
gnalling to ERKs","Role of ABL in ROBO-SLIT signaling","Anti-inflammatory response favouring Leishmania parasite infection","Cyclin D associated events in G1","Regulation of PTEN stability and activit
y","Leishmania phagocytosis","EPHA-mediated growth cone collapse","Toll Like Receptor TLR6:TLR2 Cascade","Centrosome maturation","Post NMDA receptor activation events","VEGF binds to VEGFR leading to 
receptor dimerization","IRS-mediated signalling","Sema4D in semaphorin signaling","The role of Nef in HIV-1 replication and disease pathogenesis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Dasa
tinib-resistant KIT mutants","Gastrin-CREB signalling pathway via PKC and MAPK","Imatinib-resistant PDGFR mutants","VEGFR2 mediated cell proliferation","SMAD2/3 Phosphorylation Motif Mutants in Cancer
","Signaling downstream of RAS mutants","Signalling to ERK5","MyD88 cascade initiated on plasma membrane","Mitotic Anaphase","Regulation of TP53 Activity","EPHB-mediated forward signaling","Prolonged 
ERK activation events","FCGR3A-mediated IL10 synthesis","FCGR3A-mediated phagocytosis","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Loss of proteins required for interphase microtubule org
anization from the centrosome","Long-term potentiation","PI3K Cascade","Sema4D mediated inhibition of cell attachment and migration","Nef-mediates down modulation of cell surface receptors by recruiti
ng them to clathrin adapters","Nef and signal transduction","EGFR Transactivation by Gastrin","Signalling to RAS","MAP kinase activation","Separation of Sister Chromatids","Sema4D induced cell migrati
on and growth-cone collapse","Regulation of TP53 Activity through Phosphorylation","Frs2-mediated activation","Loss of Nlp from mitotic centrosomes","Nef Mediated CD4 Down-regulation","p38MAPK events"
,"activated TAK1 mediates p38 MAPK activation"}

> <broad_targets>
{CSF1R,KDR,KIT,PDGFRB}

> <broad_moa>
{"c-Fms inhibitor"}

> <synonyms>
{"I20227 (+/",Ki20227,623142-96-1,623142961,Ki-20227,"Ki 20227",CHEMBL1908396,Ki20227(+/-),Ki20227(+/),PubChem22465,GTPL5690,SCHEMBL4475167,DTXSID80432108,SYN1049,HMS3244K11,HMS3244K12,HMS3244L11,BCP0
1956,EX-A2305,EXA2305,ABP000277,BDBM50355494,s7688,AKOS015904288,CS-0260,CS0260,NCGC002631,T4315,SY-Ki20227,"Ki20227 (+/-)"}

> <pdid>
PD012949

> <targets>
{"Other RTKs",FMS,c-Fms,c-Kit,PDGFR,VEGFR}

> <classes>
{Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{9869779}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 44  0  0  0  0            999 V2000
   10.7365   -4.8546    0.0000 Cl  0  0
    8.2365   -4.8546    0.0000 Cl  0  0
    5.7358   -9.9980    0.0000 C   0  0
    4.2445   -9.8362    0.0000 S   0  0
    3.3592  -11.0471    0.0000 O   0  0
    4.8503  -11.2085    0.0000 O   0  0
    3.6391   -8.4629    0.0000 C   0  0
    4.5250   -7.2514    0.0000 C   0  0
    3.9195   -5.8781    0.0000 N   0  0
    4.8054   -4.6666    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 S   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.6011   -3.0008    0.0000 N   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -7.8061   -5.9891    0.0000 O   0  0
   -7.8091   -7.4899    0.0000 C   0  0
   -9.1099   -8.2385    0.0000 C   0  0
   -9.1152   -9.7385    0.0000 C   0  0
  -10.4168  -10.4840    0.0000 C   0  0
  -11.7132   -9.7296    0.0000 C   0  0
  -11.7081   -8.2296    0.0000 C   0  0
  -13.0046   -7.4752    0.0000 F   0  0
  -10.4065   -7.4841    0.0000 C   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -7.7966   -2.9860    0.0000 Cl  0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  1  0
  4  5  2  0
  4  6  2  0
  4  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 11  2  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  1  0
 35 37  2  0
 37 31  1  0
 28 38  1  0
 38 39  1  0
 38 40  2  0
 40 25  1  0
 23 41  1  0
 41 19  1  0
 41 42  2  0
 42 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28338

> <plate>
Kinase v5-1

> <well>
D06

> <supplier_cmpd_name>
GW 583340 dihydrochloride

> <ctcr_id>
6282

> <supplier_cmpd_id>
2239

> <smiles>
Cl.Cl.C[S](=O)(=O)CCNCc1scc(n1)c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2

> <pd_targets>
{HSD17B10,RORC,EGFR,FFP,MAPK1,KDM4E,MAPT,KMT2A,MEN1,ALOX15,LEF,CYP3A4,ERBB2}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator","Other cytosolic protein",Oxidoreductase,"Nuclear receptor",Kinase,Transferase,Eraser,Reader,Protease,"Cytochrome P450","Nuclear hormone receptor 
subfamily 1","Protein Kinase","Lysine demethylase",Bromodomain,"Metallo protease","Cytochrome P450 family 3","Nuclear hormone receptor subfamily 1 group F","TK protein kinase group","CMGC protein kina
se group","Jumonji domain-containing","Metallo protease MAE clan","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase EGFR family","CMGC protei
n kinase MAPK family","Metallo protease M34 family","Cytochrome P450 3A4","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Catalytic receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","1F. Retinoic acid-related orphans","R
eceptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","1.14.11.- Histone demethylases",Lipoxygenases,"CYP3 family","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","R
eceptor tyrosine kinases (RTKs)","ERK subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{Metabolism,"Gene expression (Transcription)","Signal Transduction","Immune System","Neuronal System",Disease,"Developmental Biology","Metabolism of amino acids and derivatives","RNA Polymerase II Tra
nscription","Signaling by GPCR","Innate Immune System","Transmission across Chemical Synapses","Metabolism of lipids","Infectious disease","Nervous system development","Branched-chain amino acid catab
olism","Generic Transcription Pathway","GPCR downstream signalling","Toll-like Receptor Cascades","Neurotransmitter receptors and postsynaptic signal transmission","Biosynthesis of specialized proreso
lving mediators (SPMs)","Uptake and actions of bacterial toxins","Axon guidance","Transcriptional regulation by RUNX3","G alpha (q) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Activation
 of NMDA receptors and postsynaptic events","Biosynthesis of DPA-derived SPMs","Uptake and function of anthrax toxins","Biosynthesis of DHA-derived SPMs","Semaphorin interactions","RUNX3 Regulates Imm
une Response and Cell Migration","Gastrin-CREB signalling pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Post NMDA receptor activation events","Biosynthesis of DPAn-3 SPMs","B
iosynthesis of maresins","Sema4D in semaphorin signaling","EGFR Transactivation by Gastrin","MAP kinase activation","Activation of AMPK downstream of NMDARs","Biosynthesis of DPAn-3-derived protectins
 and resolvins","Biosynthesis of maresin-like SPMs","Sema4D induced cell migration and growth-cone collapse","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactiv
ated"}

> <broad_targets>
{EGFR,ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{"GW 583340 dihydrochloride",GW583340,1173023-85-2,1173023852,"GW 583340","GW583340 dihydrochloride",GW583340Dihydrochloride,GTPL4947,SCHEMBL9988095,CHEMBL1356199,AKOS024457005,NCGC00092346-01,NCGC000
9234601,EC-000.2408,EC000.2408,">=97 (H",2239}

> <pdid>
PD070626

> <targets>
{EGFR}

> <classes>
{}

> <pubchem_cids>
{16219404}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 26  0  0  0  0            999 V2000
    9.1117   -3.7308    0.0000 C   0  0
    7.8090   -2.9872    0.0000 O   0  0
    7.8007   -1.4864    0.0000 C   0  0
    9.0971   -0.7319    0.0000 C   0  0
    9.0919    0.7681    0.0000 C   0  0
    7.7903    1.5136    0.0000 C   0  0
    7.7851    3.0136    0.0000 Cl  0  0
    6.4939    0.7591    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 N   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 O   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  9  3  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 14  1  0
 24 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28339

> <plate>
Kinase v5-1

> <well>
D08

> <supplier_cmpd_name>
PQ 401

> <ctcr_id>
3485

> <supplier_cmpd_id>
2768

> <smiles>
COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23

> <pd_targets>
{IGF1R}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase InsR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","IGF1R signaling cascade","IRS-related events triggered by IGF1R"}

> <broad_targets>
{IGF1R}

> <broad_moa>
{"IGF-1 inhibitor"}

> <synonyms>
{PQ401,196868-63-0,196868630,"PQ 401",PQ-401,1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea,1(5Chloro2methoxyphenyl)3(2methylquinolin4yl)urea,"IGF-1R Inhibitor II","IGF1R Inhibitor II",TCM
DC-125497,TCMDC125497,UNII-2N3LV83S8J,UNII2N3LV83S8J,N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea,N(5Chloro2methoxyphenyl)N'(2methyl4quinolinyl)urea,2N3LV83S8J,CHEMBL439259,MFCD00160558
,K0061,T4324,"EMD 407248",2768,"PQ401 hydrochloride (196868-63-0(free base))",407248}

> <pdid>
PD002611

> <targets>
{"Insulin and insulin-like Receptors",IGF-1R}

> <classes>
{}

> <pubchem_cids>
{9549305}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 30  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5950   -3.0008    0.0000 C   0  0
   -1.2942   -3.7494    0.0000 C   0  0
   -1.2911   -5.2502    0.0000 C   0  0
    0.0091   -5.9984    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    6.3987    0.3760    0.0000 O   0  0
    6.3987   -1.1240    0.0000 C   0  0
    5.0994   -1.8736    0.0000 O   0  0
    7.6987   -1.8740    0.0000 C   0  0
    8.9987   -1.1240    0.0000 C   0  0
   10.2987   -1.8740    0.0000 C   0  0
   11.5980   -1.1244    0.0000 O   0  0
   10.2987   -3.3740    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 14 19  1  0
 19  5  1  0
 19 20  2  0
 20  2  1  0
 20 21  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  2  3
 26 27  1  0
 27 28  2  0
 27 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28340

> <plate>
Kinase v5-1

> <well>
D10

> <supplier_cmpd_name>
ER 27319 maleate

> <ctcr_id>
3327

> <supplier_cmpd_id>
2471

> <smiles>
Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C.OC(=O)C=CC(=O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{1204480-26-1,1204480261,2471,"ER 27319 maleate"}

> <pdid>

> <targets>
{"Syk Kinase",Syk}

> <classes>
{}

> <pubchem_cids>
{71433966}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 40  0  0  0  0            999 V2000
    3.1476   -0.7184    0.0000 C   0  0
    1.6852   -0.3846    0.0000 N   0  0
    1.3514    1.0778    0.0000 C   0  0
    2.5913    1.9239    0.0000 C   0  0
    2.4792    3.4197    0.0000 C   0  0
    3.7186    4.2647    0.0000 C   0  0
    3.6065    5.7605    0.0000 C   0  0
    2.2550    6.4113    0.0000 C   0  0
    1.0157    5.5663    0.0000 C   0  0
    1.1278    4.0705    0.0000 C   0  0
   -0.1116    3.2255    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.5242    2.0130    0.0000 O   0  0
   -1.6852   -0.3847    0.0000 N   0  0
   -3.1476   -0.7184    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.5000   -2.8577    0.0000 C   0  0
   -3.0000   -2.8580    0.0000 C   0  0
   -0.7500   -4.1567    0.0000 N   0  0
    0.7500   -4.1567    0.0000 C   0  0
    1.5031   -5.4549    0.0000 N   0  0
    3.0039   -5.4528    0.0000 C   0  0
    3.8680   -6.6633    0.0000 C   0  0
    5.2929   -6.1948    0.0000 N   0  0
    5.2877   -4.6948    0.0000 N   0  0
    3.8595   -4.2363    0.0000 C   0  0
    6.5101   -7.0727    0.0000 C   0  0
    6.4705   -8.5672    0.0000 C   0  0
    7.7497   -9.3506    0.0000 C   0  0
    9.0677   -8.6345    0.0000 N   0  0
    9.1066   -7.1350    0.0000 C   0  0
    7.8274   -6.3516    0.0000 C   0  0
    1.5000   -2.8577    0.0000 N   0  0
    0.7500   -1.5574    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 10 11  1  0
 11 12  2  0
 12  3  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 23  1  0
 25 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 28  1  0
 21 34  1  0
 34 35  2  0
 35  2  1  0
 35 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28342

> <plate>
Kinase v5-1

> <well>
D14

> <supplier_cmpd_name>
HTH 01-015

> <ctcr_id>
13613

> <supplier_cmpd_id>
5622

> <smiles>
Cn1c2cc3ccccc3cc2c(=O)n(C)c2c(C)nc(Nc3cn(nc3)C3CCNCC3)nc12

> <pd_targets>
{NUAK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase CAMK1 family","CAMK protein kinase NuaK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","CAMK-like (CAMKL) family","NuaK subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by TP53","Regulation of TP53 Activity","Regulation of TP53 Activity thr
ough Phosphorylation"}

> <broad_targets>
{NUAK1}

> <broad_moa>
{"protein kinase inhibitor"}

> <synonyms>
{TH0101,HTH-01-015,HTH01015,1613724-42-7,1613724427,"HTH 01 015",GTPL8977,CHEMBL4303250,SCHEMBL16065674,BCP14400,EX-A1038,EXA1038,HTH01-015,s7318,AKOS026750455,ZINC214463354,CCG-269434,CCG269434,CS-33
44,CS3344,"HTH 01-015","HTH 01015",NCGC00389591-02,NCGC0038959102,NCGC00389591-08,NCGC0038959108,AC-32959,AC32959,AK316255,AS-75146,AS75146,DA-43721,DA43721,HY-123,HY123,T2374}

> <pdid>
PD012986

> <targets>
{NUAK,NUAK1,NUAK2,AMPK}

> <classes>
{PI3K/Akt/mTOR signaling,Epigenetics,PI3K/Akt/mTOR}

> <pubchem_cids>
{78357766}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
   10.7810    3.2327    0.0000 C   0  0
    9.3959    3.8084    0.0000 C   0  0
    9.2023    5.2958    0.0000 C   0  0
    8.2035    2.8969    0.0000 C   0  0
    8.3970    1.4094    0.0000 O   0  0
    6.8176    3.4729    0.0000 N   0  0
    5.6273    2.5630    0.0000 C   0  0
    4.1890    2.9887    0.0000 N   0  0
    3.3397    1.7523    0.0000 C   0  0
    4.2568    0.5878    0.0000 C   0  0
    5.6669    1.0635    0.0000 S   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 Cl  0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
    4.8054   -4.6666    0.0000 C   0  0
    3.9200   -5.8774    0.0000 F   0  0
    6.2966   -4.8284    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  7  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 12  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 17  1  0
 23 24  1  0
 14 25  1  0
 25 26  1  0
 25 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28343

> <plate>
Kinase v5-1

> <well>
D16

> <supplier_cmpd_name>
LIMKi 3

> <ctcr_id>
3545

> <supplier_cmpd_id>
4745

> <smiles>
CC(C)C(=O)Nc1ncc(s1)c2cc(nn2c3c(Cl)cccc3Cl)C(F)F

> <pd_targets>
{LIMK1,LIMK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase LISK family","TKL protein kinase LIMK subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","LIM domain kinase (LISK) family","LIMK subfamily"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Semaphorin interactions","Sema4D in semaphorin signaling","Sema4D induced cell migration and growth-cone collapse"}

> <broad_targets>
{LIMK1}

> <broad_moa>
{"LIM kinase inhibitor"}

> <synonyms>
{MS,BMS-5,BMS5,1338247-35-0,1338247350,"LIMKi 3","BMS 5","LIMKI-3 (BMS-5)","LIMKI3 (BMS5)",LIMKi3,LIMKi-3,"LIM Kinase Inhibitor I",C17H14Cl2F2N4OS,GTPL9839,CHEMBL2141887,SCHEMBL15543888,EX-A934,EXA934
,SYN1024,CHEBI:138670,HMS3244I07,HMS3244I08,HMS3244J07,HMS3743I19,BCP17223,MFCD17019327,ZINC,T4598,SY-BMS-5}

> <pdid>
PD038518

> <targets>
{LIMK,"LIM Kinase (LIMK)"}

> <classes>
{Cell Cycle/DNA Damage}

> <pubchem_cids>
{56965901}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    7.6646   -3.8335    0.0000 Cl  0  0
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6890   -4.0818    0.0000 C   0  0
    0.2235   -5.5086    0.0000 O   0  0
    1.2256   -6.6258    0.0000 C   0  0
    0.7624   -8.0525    0.0000 C   0  0
    1.7663   -9.1671    0.0000 C   0  0
    3.2334   -8.8550    0.0000 C   0  0
    3.6967   -7.4283    0.0000 C   0  0
    5.1639   -7.1162    0.0000 Cl  0  0
    2.6929   -6.3137    0.0000 C   0  0
   -1.8032   -3.1233    0.0000 N   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -3.8813   -1.4408    0.0000 C   0  0
   -4.9619   -2.4740    0.0000 C   0  0
   -6.4014   -2.0524    0.0000 C   0  0
   -6.7561   -0.5949    0.0000 O   0  0
   -5.6713    0.4410    0.0000 C   0  0
   -4.2318    0.0194    0.0000 C   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 12  1  0
  9 19  2  0
 19 20  1  0
 20  7  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28344

> <plate>
Kinase v5-1

> <well>
D18

> <supplier_cmpd_name>
PF 4800567 hydrochloride

> <ctcr_id>
8316

> <supplier_cmpd_id>
4281

> <smiles>
Cl.Nc1ncnc2c1c(COc3cccc(Cl)c3)nn2C4CCOCC4

> <pd_targets>
{CSNK1E,CSNK1D}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CK1 protein kinase group","CK1 protein kinase CK1 family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CK1: Casein kinase 1","Casein kinase 1 (CK1) family"}

> <pathway_reactome>
{"Cell Cycle",Mitotic,"Mitotic G2-G2/M phases","G2/M Transition","Centrosome maturation","Loss of proteins required for interphase microtubule organization from the centrosome","Loss of Nlp from mitot
ic centrosomes"}

> <broad_targets>
{CSNK1D,CSNK1E}

> <broad_moa>
{"casein kinase inhibitor"}

> <synonyms>
{"PF-4800567 Hydrochloride","PF4800567 Hydrochloride",1391052-28-0,1391052280,"1391052 28 0","1391052-28-0 (HCl)","1391052280 (HCl)","1391052 28 0 (HCl)",SCHEMBL18921541,"PF-4800567 HCl","PF4800567 HC
l","PF 4800567 HCl",AKOS024,T5056,4281,PF-4800567,"PF 4800567 hydrochloride"}

> <pdid>
PD003265

> <targets>
{"Casein Kinase 1","Casein Kinase"}

> <classes>
{Cell Cycle/DNA Damage,Stem Cell/Wnt}

> <pubchem_cids>
{71751553}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    2.5532   -4.4223    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -3.8916    3.7585    0.0000 C   0  0
   -3.8864    5.2585    0.0000 C   0  0
   -2.5847    6.0040    0.0000 C   0  0
   -2.5796    7.5040    0.0000 C   0  0
   -1.2883    5.2495    0.0000 C   0  0
   -1.2935    3.7495    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 10  1  0
  8 17  1  0
 17 18  2  0
 17 19  1  0
 19  4  2  0
 19 20  1  0
 20  2  2  0
M  END
> <name>
UTKinase_V5

> <id>
28347

> <plate>
Kinase v5-1

> <well>
F04

> <supplier_cmpd_name>
Ryuvidine

> <ctcr_id>
5954

> <supplier_cmpd_id>
2609

> <smiles>
Cc1sc2C(=O)C=C(Nc3ccc(C)cc3)C(=O)c2n1

> <pd_targets>
{RORC,BLM,CCND1,CDK4,CDK2,THRB,KMT2A,MEN1,KMT5A}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator","Nuclear receptor",Kinase,Reader,Writer,"Nuclear hormone receptor subfamily 1","Protein Kinase",Bromodomain,"Protein methyltransferase","Nuclear h
ormone receptor subfamily 1 group F","CMGC protein kinase group","Nuclear hormone receptor subfamily 1 group A","SET domain","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinas
e CDK family","Nuclear hormone receptor subfamily 1 group A member 2","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","1F. Retinoic acid-related orphans","CMGC: Containing CDK",MAPK,GSK3,"CLK families","1A. Thyroid hor
mone receptors","2.1.1.43 Histone methyltransferases (HMTs)","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","CDK4 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","DNA Repair","Cell Cycle","Metabolism of proteins","RNA Polymerase II Transcription","DNA Double-Strand Break Repair",Mitotic,"Post-translational protein modificatio
n","Generic Transcription Pathway","Homology Directed Repair","Mitotic G1 phase and G1/S transition",SUMOylation,"Transcriptional regulation by RUNX3","HDR through Homologous Recombination (HRR) or Si
ngle Strand Annealing (SSA)","Transcriptional Regulation by TP53","G1 Phase","SUMO E3 ligases SUMOylate target proteins","RUNX3 Regulates Immune Response and Cell Migration","HDR through Homologous Re
combination (HRR)","Regulation of TP53 Activity","Cyclin D associated events in G1","SUMOylation of intracellular receptors","Homologous DNA Pairing and Strand Exchange","Regulation of TP53 Expression
 and Degradation","Regulation of TP53 Activity through Methylation","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation"}

> <broad_targets>
{CDK2,CDK4}

> <broad_moa>
{"histone lysine methyltransferase inhibitor"}

> <synonyms>
{Ryuvidine,"Cdk4 Inhibitor III",265312-55-8,265312558,"265312 55 8","2-Methyl-5-((4-methylphenyl)amino)benzothiazole-4,7-dione","2Methyl5((4methylphenyl)amino)benzothiazole4,7dione","2 Methyl 5 ((4 me
thylphenyl)amino)benzothiazole 4,7 dione",CHEM,"EMD 219478",2609,219478}

> <pdid>
PD017062

> <targets>
{"Lysine Methyltransferases",cdk}

> <classes>
{}

> <pubchem_cids>
{481747}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 40  0  0  0  0            999 V2000
    7.1946   -3.9356    0.0000 Cl  0  0
   -5.3306   -9.0124    0.0000 O   0  0
   -4.4785   -7.7779    0.0000 C   0  0
   -5.1224   -6.4222    0.0000 N   0  0
   -6.6174   -6.2989    0.0000 C   0  0
   -7.2581   -4.9427    0.0000 C   0  0
   -6.4040   -3.7096    0.0000 C   0  0
   -4.9090   -3.8329    0.0000 C   0  0
   -4.2683   -5.1891    0.0000 C   0  0
   -7.0450   -2.3527    0.0000 N   0  0
   -8.5092   -2.0913    0.0000 C   0  0
   -8.6971   -0.6032    0.0000 C   0  0
   -7.3398    0.0355    0.0000 C   0  0
   -6.3131   -1.0580    0.0000 C   0  0
   -2.9826   -7.8991    0.0000 C   0  0
   -2.3371   -9.2532    0.0000 C   0  0
   -0.8418   -9.3712    0.0000 C   0  0
    0.0082   -8.1352    0.0000 C   0  0
    1.5046   -8.2503    0.0000 N   0  0
    2.3532   -7.0124    0.0000 C   0  0
    3.8490   -7.1253    0.0000 N   0  0
    4.6946   -5.8864    0.0000 C   0  0
    4.0445   -4.5346    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.7031   -5.6606    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 S   0  0
   -0.6374   -6.7812    0.0000 C   0  0
   -2.1327   -6.6631    0.0000 C   0  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 10  1  0
  3 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 24 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 33 34  1  0
 34 26  1  0
 18 35  1  0
 35 36  2  0
 36 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28348

> <plate>
Kinase v5-1

> <well>
F06

> <supplier_cmpd_name>
IKK 16

> <ctcr_id>
4483

> <supplier_cmpd_id>
2539

> <smiles>
Cl.O=C(N1CCC(CC1)N2CCCC2)c3ccc(Nc4nccc(n4)c5cc6ccccc6s5)cc3

> <pd_targets>
{IKBKB,CHUK,RECQL,BLM,FFP,RORC,IKBKG,PRKCZ}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,Transferase,"Nuclear receptor","Protein Kinase","Nuclear hormone receptor subfamily 1","Other protein kinase group","Nuclear hormone receptor subfamily 1 group F"
,"AGC protein kinase group","Other protein kinase IKK family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKC family","AGC protein kinase PKC iota subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Receptor kinases","1F. Retinoic acid-related orphans","AGC: Containing PKA",PKG,"PKC families","Other prote
in kinases","Protein kinase C (PKC) family","IKK family","Iota subfamily"}

> <pathway_reactome>
{"Immune System","DNA Repair","Gene expression (Transcription)","Signal Transduction","Innate Immune System","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Signaling by Nuclear Re
ceptors","Toll-like Receptor Cascades","Homology Directed Repair","Generic Transcription Pathway","ESR-mediated signaling","Toll Like Receptor 4 (TLR4) Cascade","HDR through Homologous Recombination (
HRR) or Single Strand Annealing (SSA)","Transcriptional regulation by RUNX3","Extra-nuclear estrogen signaling","MyD88-independent TLR4 cascade","HDR through Homologous Recombination (HRR)","RUNX3 Reg
ulates Immune Response and Cell Migration","Estrogen-stimulated signaling through PRKCZ","TRIF(TICAM1)-mediated TLR4 signaling","Homologous DNA Pairing and Strand Exchange","IKK complex recruitment me
diated by RIP1","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor"}

> <synonyms>
{1186195-62-9,1186195629,"1186195 62 9","IKK-16 HCl","IKK16 HCl","IKK 16 HCl","IKK 16 (hydrochloride)",IKK-16,IKK16,"IKK 16","IKK 16 hydrochloride","1186195-62-9 (HCl)","1186195629 (HCl)","1186195 62 
9 (HCl)",AOB1285,BCP08242,HY-13687A,HY13687A,H,2539}

> <pdid>
PD010532

> <targets>
{"IkB Kinase",IKK}

> <classes>
{}

> <pubchem_cids>
{56972179}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 N   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 C   0  0
   -1.2942   -8.2509    0.0000 O   0  0
    0.0036   -7.4988    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  1  0
 18  8  1  0
 18 12  2  0
 16 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28349

> <plate>
Kinase v5-1

> <well>
F08

> <supplier_cmpd_name>
PI 828

> <ctcr_id>
3560

> <supplier_cmpd_id>
2814

> <smiles>
Nc1ccc(cc1)c2cccc3C(=O)C=C(Oc23)N4CCOCC4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{942289-87-4,942289874,PI-828,PI828,"PI 828",8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one,8(4Aminophenyl)2(4morpholinyl)4H1benzopyran4one,8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-
4-one,8(4aminophenyl)2(4morpholinyl)1benzopyran4one,"LY 294002, 4gamma-NH2","LY 294002, 4gammaNH2",8-(4-aminophenyl)-2-morpholino-4H-chromen-4-one,8(4aminophenyl)2morpholino4Hchromen4one,SCHEMBL137000
43,CHEBI:93710,DTXSI,2814,"EMD 440206",440206}

> <pdid>
PD021756

> <targets>
{"PI 3-Kinase",4'-NH2,"LY 294002",PI3K}

> <classes>
{}

> <pubchem_cids>
{25181195}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 30  0  0  0  0            999 V2000
    3.1882    2.6402    0.0000 O   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 N   0  0
    2.7248   -1.2135    0.0000 C   0  0
    3.1882   -2.6401    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.4135    4.4923    0.0000 C   0  0
   -1.5318    5.7059    0.0000 C   0  0
   -0.0400    5.5491    0.0000 C   0  0
    0.5701    4.1788    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.4134   -4.4924    0.0000 C   0  0
   -1.5318   -5.7059    0.0000 C   0  0
   -0.0400   -5.5491    0.0000 C   0  0
    0.5701   -4.1788    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  8  1  0
 16 11  1  0
  9 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 24 25  1  0
 25  6  1  0
 25 17  2  0
M  END
> <name>
UTKinase_V5

> <id>
28350

> <plate>
Kinase v5-1

> <well>
F10

> <supplier_cmpd_name>
Arcyriaflavin A

> <ctcr_id>
1117

> <supplier_cmpd_id>
2457

> <smiles>
O=C1NC(=O)c2c1c3c([nH]c4ccccc34)c5[nH]c6ccccc6c25

> <pd_targets>
{CCNB1,CCNB2,CCNB3,CDK1,KMT2A,MEN1,MAPT,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,CCNE1,CCNE2,CDK2,CCND1,CDK4,PRKACA,PRKACB,PRKACG,CCNA2,CAMK2A,CAMK2B,CAMK2D,CAMK2G,CDK5,CDK5R1
}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein",Kinase,Reader,Protease,"Protein Kinase",Bromodomain,"Cysteine protease","CMGC protein kinase group","AGC protein kinase group","Cysteine protea
se CA clan","CAMK protein kinase group","CMGC protein kinase CDK family","AGC protein kinase PKC family","Cysteine protease C1A family","AGC protein kinase PKA family","CAMK protein kinase CAMK2 famil
y","CMGC protein kinase CDC2 subfamily","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Protein kinase C (PKC) family","Protein kinase A (PKA) family","Delta subfamily"}

> <pathway_reactome>
{"Neuronal System","Signal Transduction","Cell Cycle","Transmission across Chemical Synapses","Signaling by GPCR",Mitotic,"Neurotransmitter receptors and postsynaptic signal transmission","GPCR downst
ream signalling","Mitotic G2-G2/M phases","Activation of NMDA receptors and postsynaptic events","G alpha (i) signalling events","G2/M Transition","Post NMDA receptor activation events","Visual photot
ransduction","Centrosome maturation","Activation of AMPK downstream of NMDARs","The phototransduction cascade","Loss of proteins required for interphase microtubule organization from the centrosome",I
nactivation,"recovery and regulation of the phototransduction cascade","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{CCND1,CDK4}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{"arcyriaflavin a",118458-54-1,118458541,"12,13-Dihydro-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione","12,13Dihydro5Hindolo(2,3a)pyrrolo(3,4c)carbazole5,7(6H)dione",CHEMBL268368,LSM-3627,LSM3
627,"Arcyriaflavin A, Synthetic",arcyriaflavin-a,arcyriaflavina,"STAUROSPORINE AGLYCON",BDBM2672,SCHEMBL8124103,CHEBI:93276,DTXSID5041613,2457,"EMD 181305","Arcyriaflavin A",181305}

> <pdid>
PD038554

> <targets>
{"Cyclin-dependent Kinase",cdk,"Arcyriaflavin A",Synthetic}

> <classes>
{}

> <pubchem_cids>
{5327723}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 F   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 F   0  0
    3.8975   -2.2510    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    2.6016    2.9971    0.0000 O   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 N   0  0
    0.0079    7.5003    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 N   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
  7 17  2  0
 17 18  1  0
 18 19  2  0
 19  5  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28353

> <plate>
Kinase v5-1

> <well>
F16

> <supplier_cmpd_name>
SRPIN340

> <ctcr_id>
11589

> <supplier_cmpd_id>
5063

> <smiles>
FC(F)(F)c1cc(NC(=O)c2ccncc2)c(cc1)N1CCCCC1

> <pd_targets>
{SRPK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase SRPK family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","SRPK family"}

> <pathway_reactome>
{}

> <broad_targets>
{SRPK1,SRPK2}

> <broad_moa>
{"serine arginine protein kinase inhibitor"}

> <synonyms>
{SRPIN340,218156-96-8,218156968,"SRPIN 340",N-(2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide,N(2(Piperidin1yl)5(trifluoromethyl)phenyl)isonicotinamide,"SRPK inhibitor",SRPIN-340,N-(2-(1
-Piperidinyl)-5-(trifluoromethyl)phenyl)-4-pyridinecarboxamide,N(2(1Piperidinyl)5(trifluoromethyl)phenyl)4pyridinecarboxamide,CHEMBL4064277,N-(2-piperidin-1-yl-5-(trifluoromethyl,N(2piperidin1yl5(trif
luoromethyl,T1954}

> <pdid>
PD010372

> <targets>
{"Other Kinases",SRPK1,SRPK,"Virus Protease"}

> <classes>
{Tyrosine Kinase/Adaptors,Anti-infection,Cell Cycle/DNA Damage}

> <pubchem_cids>
{2797577}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  1  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0  2  0  0  0
   -1.4470    5.2297    0.0000 C   0  0  2  0  0  0
   -2.9153    5.5365    0.0000 C   0  0
   -3.6607    4.2349    0.0000 O   0  0
   -2.6532    3.1236    0.0000 C   0  0
   -2.9512    1.6535    0.0000 O   0  0
   -0.3273    6.2252    0.0000 C   0  0
    1.0974    5.7534    0.0000 C   0  0
    2.2199    6.7484    0.0000 C   0  0
    3.6428    6.2739    0.0000 C   0  0
    3.9434    4.8044    0.0000 C   0  0
    5.3682    4.3326    0.0000 O   0  0
    6.4892    5.3293    0.0000 C   0  0
    2.8210    3.8093    0.0000 C   0  0
    3.1188    2.3383    0.0000 O   0  0
    1.9950    1.3448    0.0000 C   0  0
    1.3981    4.2837    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  7  6  1  1
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11  7  1  0
 11 12  2  0
  8 13  1  6
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 20 23  2  0
 23 14  1  0
  5 24  2  0
 24 25  1  0
 25 26  2  0
 26  3  1  0
 26 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28357

> <plate>
Kinase v5-1

> <well>
H04

> <supplier_cmpd_name>
Arctigenin

> <ctcr_id>
7685

> <supplier_cmpd_id>
1777

> <smiles>
COc1cc(C[C@@H]2[C@H](COC2=O)Cc3ccc(OC)c(OC)c3)ccc1O

> <pd_targets>
{CYP2C9,MAP2K1,CYP2C19,RORC,CYP3A4,MAPK1,CYP1A2}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Cytochrome P450",Kinase,"Nuclear receptor","Cytochrome P450 family 2","Protein Kinase","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3","Cytochrome P45
0 family 1","Cytochrome P450 family 2C","STE protein kinase group","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 3A","CMGC protein kinase group","Cytochrome P450 family 1A","C
ytochrome P450 2C9","STE protein kinase STE7 family","Cytochrome P450 2C19","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 3A4","CMGC protein kinase MAPK family","Cytochrome 
P450 1A1","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","CYP2 family: drug metabolising subset","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","1F
. Retinoic acid-related orphans","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP1 family","STE7 family","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Signal Transduction","Gene expression (Transcription)","Immune System","Biological oxidations","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Metabolism of li
pids","Innate Immune System","Phase I - Functionalization of compounds","Signaling by NTRKs","Generic Transcription Pathway","Biosynthesis of specialized proresolving mediators (SPMs)","Toll-like Rece
ptor Cascades","Cytochrome P450 - arranged by substrate type","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX3","Biosynthesis of DHA-derived SPMs","Toll Like Receptor 5 (TLR5) Cascade"
,Xenobiotics,"Signalling to ERKs","RUNX3 Regulates Immune Response and Cell Migration","Biosynthesis of maresins","MyD88 cascade initiated on plasma membrane","CYP2E1 reactions","Prolonged ERK activat
ion events","Biosynthesis of maresin-like SPMs","MAP kinase activation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Frs2-mediated activation","MAPK targets/ Nuclear events medi
ated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{CHUK,MAP2K1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{Arctigenin,(-)-Arctigenin,()Arctigenin,7770-78-7,7770787,UNII-U76MR9VS6M,UNIIU76MR9VS6M,C21H24O6,CHEBI:79,U76MR9VS6M,(+/-)-Arctigenin,(+/)Arctigenin,"Arctigenin, (+/-)-","Arctigenin, (+/)",Arctigenen
,"Arctigenin, trans-((+/-)-","Arctigenin, trans((+/)",Tocris-1777,Tocris1777,SCHEMBL381820,CHEMBL435734,MEGxp0_001799,MEGxp0001799,MEGxp0-001799,"MEGxp0 001799",ACon1_000416,ACon1000416,ACon1-000416,"
ACon1 000416",DTXSID60998919,HMS32,1777}

> <pdid>
PD012062

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{64981}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
   10.2891   -2.6236    0.0000 Cl  0  0
    7.7884    1.5181    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    5.2059   -2.9909    0.0000 F   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8963   -3.7531    0.0000 O   0  0
   -3.8941   -5.2539    0.0000 C   0  0
   -5.1923   -6.0070    0.0000 C   0  0
   -5.1924   -7.5071    0.0000 C   0  0
   -6.4914   -8.2571    0.0000 C   0  0
   -7.7905   -7.5071    0.0000 C   0  0
   -7.7905   -6.0071    0.0000 C   0  0
   -6.4915   -5.2571    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    5.1852    3.0091    0.0000 O   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 15 24  2  0
 24 25  1  0
 25 26  2  0
 26  9  1  0
 26 13  1  0
  7 27  1  0
 27 28  2  0
 28  3  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28358

> <plate>
Kinase v5-1

> <well>
H06

> <supplier_cmpd_name>
ZM 323881 hydrochloride

> <ctcr_id>
6639

> <supplier_cmpd_id>
2475

> <smiles>
Cl.Cc1cc(F)c(Nc2ncnc3cc(OCc4ccccc4)ccc23)cc1O

> <pd_targets>
{KDR,MAPT}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein",Kinase,Protease,"Protein Kinase","Cysteine protease","TK protein kinase group","Cysteine protease CA clan","Tyrosine protein kinase VEGFR family","Cysteine protease C
1A family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System","Signaling by Receptor Tyrosine Kinases","Transmission across Chemical Synapses","Signaling by VEGF","Neurotransmitter receptors and postsynaptic signal transm
ission","VEGFA-VEGFR2 Pathway","Activation of NMDA receptors and postsynaptic events","VEGFR2 mediated cell proliferation","Post NMDA receptor activation events","Activation of AMPK downstream of NMDA
Rs"}

> <broad_targets>
{KDR}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{193000-39-4,193000394,"193000 39 4","ZM323881 hydrochloride",324077-30-7,324077307,"324077 30 7","ZM323881 (hydrochloride)","ZM 323881 HCl","5-((7-BENZYLOXYQUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHE
NOL HYDROCHLORIDE","5((7BENZYLOXYQUINAZOLIN4YL)AMINO)4FLUORO2METHYLPHENOL HYDROCHLORIDE","5 ((7 BENZYLOXYQUINAZOLIN 4 YL)AMINO) 4 FLUORO 2 METHYLPHENOL HYDROCHLORIDE","ZM323881 HCl","193000-39-4 (HCl)
","193000394 (HCl)","193000 39 4 (HCl)",C22H19Cl,T1991,2475,S2896,"ZM 323881 hydrochloride"}

> <pdid>
PD070764

> <targets>
{VEGFR}

> <classes>
{Protein Tyrosine Kinase,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{22624897}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    7.7858   -9.1806    0.0000 N   0  0
    6.3110   -8.9071    0.0000 C   0  0
    5.3370  -10.0479    0.0000 O   0  0
    5.8106   -7.4921    0.0000 C   0  0
    6.7829   -6.3499    0.0000 C   0  0
    6.2798   -4.9368    0.0000 C   0  0
    4.8092   -4.6676    0.0000 C   0  0
    3.8322   -5.8080    0.0000 C   0  0
    4.3352   -7.2212    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 12 19  2  0
 19 20  1  0
 20 10  2  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 29 30  2  0
 30 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28359

> <plate>
Kinase v5-1

> <well>
H08

> <supplier_cmpd_name>
D 4476

> <ctcr_id>
2337

> <supplier_cmpd_id>
2902

> <smiles>
NC(=O)c1ccc(cc1)c2[nH]c(c3ccccn3)c(n2)c4ccc5OCCOc5c4

> <pd_targets>
{CSNK1A1,CSNK1D,MAPK14,CKA1,CSNK1E,PRKD1,CSNK1G1,CSNK1G2,TGFBR1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CK1 protein kinase group","CMGC protein kinase group","CAMK protein kinase group","TKL protein kinase group","CK1 protein kinase CK1 family","CMGC protein kinase MAPK 
family","CMGC protein kinase CK subfamily","CAMK protein kinase PKD family","TKL protein kinase STKR family","CMGC protein kinase p38 subfamily","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CK1: Casein kinase 1","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor ki
nases","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase D (PKD) family","TKL: Tyrosine kinase-like","p38 subfamily","Receptor serine/threonine kinase (R
STK) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{Disease,"Cell Cycle","Immune System",Metabolism,"Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Innate Immune System","Metabolism of lipids","Signaling by 
WNT in cancer","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Sphingolipid metabolism","Signaling by TGF-beta Receptor Complex in Cancer","Signaling by AMER1 mutants","G2/M Transition","Toll 
Like Receptor 5 (TLR5) Cascade","Sphingolipid de novo biosynthesis","Loss of Function of SMAD2/3 in Cancer","Truncations of AMER1 destabilize the destruction complex","Centrosome maturation","MyD88 ca
scade initiated on plasma membrane","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Loss of proteins required for interphase microtubule organization from the centrosome","MAP kinase activation","L
oss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{301836-43-1,301836431,D4476,"CK1 Inhibitor","casein kinase I inhibitor","D 4476",D-4476,"Casein Kinase I Inhibitor, D4476",CHEMBL410456,C23H18N4O3,K00227,MLS006010815,SCHEMBL373737,"InSolution&trade;
 Casein Kinase I Inhibitor, D4476",GTPL5940,SCHEMBL22857113,T2449,"EMD 218696",SY-D4476,2902,218696}

> <pdid>
PD012959

> <targets>
{"Casein Kinase 1",CK1}

> <classes>
{}

> <pubchem_cids>
{6419753}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 37  0  0  0  0            999 V2000
    2.6030   -2.9977    0.0000 O   0  5
    2.6003   -1.4977    0.0000 N   0  3
    3.8983   -0.7459    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -2.6017    2.9971    0.0000 S   0  0
   -1.3070    5.2502    0.0000 N   0  0
   -2.6078    5.9988    0.0000 C   0  0
   -2.6109    7.4996    0.0000 N   0  0
   -3.9118    8.2481    0.0000 C   0  0
   -5.2095    7.4959    0.0000 O   0  0
   -3.9149    9.7490    0.0000 C   0  0
   -5.2157   10.4975    0.0000 C   0  0
   -5.2210   11.9975    0.0000 C   0  0
   -6.5226   12.7430    0.0000 C   0  0
   -7.8190   11.9885    0.0000 C   0  0
   -7.8138   10.4885    0.0000 C   0  0
   -6.5122    9.7430    0.0000 C   0  0
   -2.6165   10.5016    0.0000 C   0  0
   -2.6170   12.0017    0.0000 C   0  0
   -1.3182   12.7522    0.0000 C   0  0
   -0.0189   12.0027    0.0000 C   0  0
   -0.0183   10.5027    0.0000 C   0  0
   -1.3171    9.7522    0.0000 C   0  0
   -3.9078    5.2487    0.0000 C   0  0
   -5.2071    5.9983    0.0000 Cl  0  0
   -5.2068    4.4985    0.0000 Cl  0  0
   -3.9078    3.7487    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 15 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 11 28  1  0
 28 29  1  0
 28 30  1  0
 28 31  1  0
  6 32  2  0
 32 33  1  0
 33 34  2  0
 34  4  1  0
 34 35  1  0
M  CHG  2   1  -1   2   1
M  END
> <name>
UTKinase_V5

> <id>
28360

> <plate>
Kinase v5-1

> <well>
H10

> <supplier_cmpd_name>
CGK 733

> <ctcr_id>
6787

> <supplier_cmpd_id>
2639

> <smiles>
[O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c3ccccc3)C(Cl)(Cl)Cl)ccc1F

> <pd_targets>
{ATM,KMT2A,MEN1,RORC,ATR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Transcription factor",Kinase,Reader,"Nuclear receptor","Protein Kinase",Bromodomain,"Nuclear hormone receptor subfamily 1","Atypical protein kinase group","Nuclear horm
one receptor subfamily 1 group F","Atypical protein kinase PIKK family","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Nuclear hormone receptors",Atypical,"1F. Retinoic acid-related orphans","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Other PIKK family ki
nases","ATR subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)","DNA Repair","Cell Cycle Checkpoints","RNA Polymerase II Transcription","DNA Double-Strand Break Repair","G1/S DNA Damage Checkpoints","Generic Transcri
ption Pathway","Homology Directed Repair","p53-Dependent G1/S DNA damage checkpoint","Transcriptional regulation by RUNX3","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)"
,"p53-Dependent G1 DNA Damage Response","RUNX3 Regulates Immune Response and Cell Migration","HDR through Homologous Recombination (HRR)","Stabilization of p53","Homologous DNA Pairing and Strand Exch
ange","Autodegradation of the E3 ubiquitin ligase COP1","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{ATM,ATR}

> <broad_moa>
{"ATM kinase inhibitor","ATR kinase inhibitor"}

> <synonyms>
{CGK733,905973-89-9,905973899,"CGK 733",CGK-733,"ATM/ATR Kinase Inhibitor","Diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea",CHEMBL1221601,UNII-L3DGZ99QYM,UNIIL3DGZ99QYM,L3DGZ99QYM,EC-000.
1970,EC000.1970,GTPL5929,SCHEMBL1980806,CHEBI:91739,AOB6206,DTXSID30424997,EX-A177,EXA177,T1821,"EMD 118501",2639,118501}

> <pdid>
PD010604

> <targets>
{"Other Apoptosis",ATR/ATM}

> <classes>
{}

> <pubchem_cids>
{6605258}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
   -3.9477   -7.1844    0.0000 C   0  0
   -2.8628   -6.1485    0.0000 C   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 C   0  0
   -3.2175   -4.6910    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 S   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -5.2003   -1.4932    0.0000 C   0  0
   -6.4990   -0.7410    0.0000 C   0  0
   -6.4964    0.7590    0.0000 O   0  0
   -7.7996   -1.4883    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  2  0
 15 22  2  0
 22  8  1  0
 22 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28361

> <plate>
Kinase v5-1

> <well>
H12

> <supplier_cmpd_name>
TTP 22

> <ctcr_id>
7651

> <supplier_cmpd_id>
4432

> <smiles>
Cc1ccc(cc1)c2csc3ncnc(SCCC(O)=O)c23

> <pd_targets>
{CSNK2A1,CSNK2A2,CSNK2B}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase CK2 family"}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
{CSNK2A1}

> <broad_moa>
{"casein kinase inhibitor"}

> <synonyms>
{"TTP 22",329907-28-0,329907280,TTP22,"3-(5-(4-methylphenyl)thieno(2,3-d)pyrimidin-4-yl)sulfanylpropanoic acid","3(5(4methylphenyl)thieno(2,3d)pyrimidin4yl)sulfanylpropanoic acid","3-((5-(p-Tolyl)thie
no(2,3-d)pyrimidin-4-yl)thio)propanoic acid","3((5(pTolyl)thieno(2,3d)pyrimidin4yl)thio)propanoic acid",TTP-22,3-((5-(4-methylphenyl)thieno(2,3((5(4methylphenyl)thieno(2,"3-d)pyrimidin-4-yl)sulfanyl)p
ropanoic aci","3d)pyrimidin4yl)sulfanyl)propanoic aci",T1828,nan}

> <pdid>
PD012573

> <targets>
{"Casein Kinase 2","Casein Kinase II Inhibitor","Casein Kinase"}

> <classes>
{Cell Cycle/DNA Damage,Stem Cell/Wnt}

> <pubchem_cids>
{1536915}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 N   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -7.7942    1.4999    0.0000 N   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -7.7934   -1.5031    0.0000 C   0  0
   -9.0937   -0.7554    0.0000 O   0  0
   -7.7912   -3.0031    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  2  0
 15  9  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18  7  1  0
 18 19  2  0
 19  4  1  0
 13 20  1  0
 20 21  1  0
 20 22  2  0
M  END
> <name>
UTKinase_V5

> <id>
28362

> <plate>
Kinase v5-1

> <well>
H14

> <supplier_cmpd_name>
Amlexanox

> <ctcr_id>
533

> <supplier_cmpd_id>
4857

> <smiles>
CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(O)=O

> <pd_targets>
{KDM4E,PYK,RORC,TBK1,IKBKE,GAA,PKM,RAB9A,ALD,NPC1,GPR35,ABCC4,PDE4A,PDE4B,PDE4C,PDE4D,S100A12,S100A13,IL3,FGF1}

> <pathway_gtopdb>
{"Epigenetic regulator",Enzyme,"Transcription factor",Transporter,"Membrane receptor","Secreted protein",Eraser,Transferase,"Nuclear receptor",Kinase,Hydrolase,"Family A G protein-coupled receptor","P
rimary active transporter",Phosphodiesterase,"Lysine demethylase","Nuclear hormone receptor subfamily 1","Protein Kinase","Small molecule receptor (family A GPCR)","ATP-binding cassette","Phosphodiest
erase 4","Jumonji domain-containing","Nuclear hormone receptor subfamily 1 group F","Other protein kinase group","Carboxylic acid receptor","ABCC subfamily","Phosphodiesterase 4A","Nuclear hormone rec
eptor subfamily 1 group F member 3","Other protein kinase IKK family","Kynurenic acid receptor"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Chromatin modifying enzymes","Nuclear hormone receptors","Catalytic receptors","3.2.1.- Glycosidases","2.7.1.40 Pyruvate kinases","SLC superfamily of solute carriers",
"G protein-coupled receptors","ATP-binding cassette transporter family","1.14.11.- Histone demethylases","1F. Retinoic acid-related orphans","Receptor kinases","SLC65 NPC-type cholesterol transporters
","Orphan and other 7TM receptors","ABCC subfamily","Other protein kinases","Class A Orphans","IKK family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System",Disease,Metabolism,"Signal Transduction","Transport of small molecules",Hemostasis,"RNA Polymerase II Transcription","Innate Immune System","Diseases
 of metabolism","Metabolism of carbohydrates","Signaling by Rho GTPases","Plasma lipoprotein assembly",remodeling,"and clearance","Signaling by GPCR","Platelet activation","signaling and aggregation",
"Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","Toll-like Receptor Cascades","Diseases of carbohydrate metabolism","Glucose metaboli
sm","Rho GTPase cycle","Plasma lipoprotein clearance","GPCR ligand binding","Response to elevated platelet cytosolic Ca2+","Signaling by FGFR in disease","Transcriptional regulation by RUNX3","Toll Li
ke Receptor 4 (TLR4) Cascade","Glycogen storage diseases",Glycolysis,"RHOBTB GTPase Cycle","LDL clearance","Class A/1 (Rhodopsin-like receptors)","Platelet degranulation","Toll Like Receptor 5 (TLR5) 
Cascade","Transcriptional regulation by RUNX1","Signaling by FGFR3 in disease","RUNX3 Regulates Immune Response and Cell Migration","MyD88-independent TLR4 cascade","Glycogen storage disease type II (
GAA)","RHOBTB3 ATPase cycle","MyD88 cascade initiated on plasma membrane","RUNX1 regulates transcription of genes involved in interleukin signaling","Signaling by FGFR3 point mutants in cancer","TRIF(
TICAM1)-mediated TLR4 signaling","TAK1 activates NFkB by phosphorylation and activation of IKKs complex","FGFR3 mutant receptor activation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Sign
aling by activated point mutants of FGFR3"}

> <broad_targets>
{FGF1,IL3,PDE4A,PDE4B,PDE4C,PDE4D,S100A12,S100A13}

> <broad_moa>
{"histamine receptor modulator"}

> <synonyms>
{amlexanox,68302-57-8,68302578,Amoxanox,Aphthasol,"2-Amino-7-isopropyl-5-oxo-5H-chromeno(2,3-b)pyridine-3-carboxylic acid","2Amino7isopropyl5oxo5Hchromeno(2,3b)pyridine3carboxylic acid",Amlenanox,"Aml
exanoxum (Latin)",AA-673,AA673,"Amlexanoxo (Spanish)",Amlexanoxo,Amlexanoxum,"CHX 3673","AA 673",CHX-3673,CHX3673,UNII-BRL1C2459K,UNIIBRL1C2459K,2,T1639,SAM001246669,Amlexanox,CPD000466352}

> <pdid>
PD001296

> <targets>
{"Immunology & Inflammation related",IKK}

> <classes>
{NF-ºB}

> <pubchem_cids>
{2161}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
    7.7884    1.5181    0.0000 F   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0049   -5.9994    0.0000 C   0  0
    0.0080   -7.5002    0.0000 C   0  0
    1.3070   -8.2503    0.0000 C   0  0
    1.3071   -9.7503    0.0000 C   0  0
    0.0081  -10.5003    0.0000 C   0  0
   -1.2910   -9.7503    0.0000 N   0  0
   -1.2910   -8.2503    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.5988    1.5004    0.0000 C   0  0
    3.8978    2.2504    0.0000 N   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    5.1852    3.0091    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 14 23  1  0
 23 24  2  0
 24  7  1  0
 24 11  1  0
  8 25  1  0
 25 26  3  0
  5 27  1  0
 27 28  2  0
 28  2  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28363

> <plate>
Kinase v5-1

> <well>
H16

> <supplier_cmpd_name>
TC-S 7006

> <ctcr_id>
3239

> <supplier_cmpd_id>
5240

> <smiles>
Fc1ccc(Nc2c(cnc3cnc(NCc4cccnc4)cc23)C#N)cc1Cl

> <pd_targets>
{MAP3K8,MAPK11,MAPK12,MAPK13,MAPK14,EIF2AK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","CMGC protein kinase group","Other protein kinase group","STE protein kinase STE11 family","CMGC protein kinase MAPK family","Other protein k
inase PEK family","CMGC protein kinase p38 subfamily","Other protein kinase PKR"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","STE-unique family","Other protein kinases","PEK
 family","Other PEK family kinases"}

> <pathway_reactome>
{"Immune System",Disease,"Cytokine Signaling in Immune system","Infectious disease","Signaling by Interleukins","Influenza Infection","Interleukin-1 family signaling","NS1 Mediated Effects on Host Pat
hways","Interleukin-1 signaling","Inhibition of PKR","MAP3K8 (TPL2)-dependent MAPK1/3 activation"}

> <broad_targets>
{MAP3K8}

> <broad_moa>
{"MAP kinase inhibitor"}

> <synonyms>
{"Tpl2 Kinase Inhibitor",871307-18-5,871307185,"TC-S 7006","TCS 7006","Tpl2 Kinase Inhibitor 1",CHEMBL200381,K00599a,Tpl2-IN-2p,Tpl2IN2p,GTPL6051,SCHEMBL2369872,DTXSID00429555,HMS3229O22,BCP16321,BDBM
50173832,TC-S-7006,TCS7006,ZINC20148981,AKOS015917405,CCG-206888,CCG206888,NCGC0,"EMD 616373",616373}

> <pdid>
PD015679

> <targets>
{"Other Kinases"}

> <classes>
{}

> <pubchem_cids>
{9549300}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 46  0  0  0  0            999 V2000
    2.6098   -2.9775    0.0000 C   0  0
    1.3149   -3.7347    0.0000 C   0  0
    0.0106   -2.9924    0.0000 N   0  0
   -1.2854   -3.7477    0.0000 C   0  0
   -2.5875   -3.0031    0.0000 C   0  0
   -2.5937   -1.5031    0.0000 N   0  0
   -1.2977   -0.7477    0.0000 C   0  0
    0.0044   -1.4924    0.0000 C   0  0
   -3.8950   -0.7554    0.0000 C   0  0
   -5.1922   -1.5084    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -7.7985    2.9932    0.0000 C   0  0
   -9.0967    3.7462    0.0000 N   0  0
   -9.0947    5.2471    0.0000 C   0  0
  -10.3911    6.0016    0.0000 N   0  0
  -10.3859    7.5016    0.0000 C   0  0
   -9.0843    8.2471    0.0000 C   0  0
   -9.0792    9.7471    0.0000 F   0  0
   -7.7879    7.4927    0.0000 C   0  0
   -6.4840    8.2360    0.0000 N   0  0
   -5.1879    7.4792    0.0000 C   0  0
   -3.8837    8.2202    0.0000 C   0  0
   -2.5898    7.4613    0.0000 C   0  0
   -2.6002    5.9613    0.0000 C   0  0
   -3.9043    5.2203    0.0000 C   0  0
   -5.1982    5.9792    0.0000 C   0  0
   -1.3072    5.1993    0.0000 C   0  0
   -0.0017    5.9381    0.0000 O   0  0
   -1.3197    3.6985    0.0000 N   0  0
   -0.0267    2.9365    0.0000 C   0  0
    1.2776    3.6775    0.0000 C   0  0
    2.5714    2.9185    0.0000 C   0  0
    2.5611    1.4186    0.0000 C   0  0
    1.2569    0.6776    0.0000 C   0  0
   -0.0369    1.4365    0.0000 C   0  0
   -1.3411    0.6955    0.0000 Cl  0  0
   -7.7930    5.9927    0.0000 N   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  6  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 27 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 37  1  0
 37 38  2  0
 38 33  1  0
 38 39  1  0
 22 40  2  0
 40 17  1  0
 15 41  1  0
 41 42  2  0
 42 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28365

> <plate>
Kinase v5-1

> <well>
H20

> <supplier_cmpd_name>
TC-S 7010

> <ctcr_id>
2082

> <supplier_cmpd_id>
5286

> <smiles>
CCN1CCN(CC1)C(=O)Cc2ccc(Nc3ncc(F)c(Nc4ccc(cc4)C(=O)Nc5ccccc5Cl)n3)cc2

> <pd_targets>
{AURKA,AURKB,AURKC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Aurora kinase (Aur) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","M Phase","Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase
","Regulation of TP53 Activity","Mitotic Anaphase","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids"}

> <broad_targets>
{AURKA}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{"Aurora A Inhibitor I",1158838-45-9,1158838459,"1158838 45 9","2,4-Bisanilinopyrimidine, 10","2,4Bisanilinopyrimidine, 10","2,4 Bisanilinopyrimidine, 10",Aurora-A-inhibitor-I,AuroraAinhibitorI,"Auror
a A inhibitor I",TCS7010,"TC-S 7010","TCS 7010",T,S1451}

> <pdid>
PD011189

> <targets>
{Aurora,"Aurora Kinase"}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{44139710}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  0  0            999 V2000
    8.9837   -4.5059    0.0000 Cl  0  0
    2.5912   -7.5086    0.0000 C   0  0
    2.5917   -6.0086    0.0000 C   0  0
    1.2926   -5.2586    0.0000 C   0  0
    3.8912   -5.2578    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    5.1873   -7.5117    0.0000 C   0  0
    6.4837   -8.2663    0.0000 C   0  0
    6.4785   -9.7663    0.0000 C   0  0
    5.1769  -10.5118    0.0000 C   0  0
    3.8804   -9.7573    0.0000 C   0  0
    3.8856   -8.2573    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  1  0
 18 19  2  0
 19 10  1  0
  5 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28367

> <plate>
Kinase v5-1

> <well>
J04

> <supplier_cmpd_name>
ZM 39923 hydrochloride

> <ctcr_id>
1489

> <supplier_cmpd_id>
1367

> <smiles>
Cl.CC(C)N(CCC(=O)c1ccc2ccccc2c1)Cc3ccccc3

> <pd_targets>
{ALOX12,MAPT,LEF,TP53,JAK1,JAK3,HIF1A,ALDH1A1,CYP3A4,CYP2C9,TGM2,HSD17B10,CYP2C19,RORC,CYP1A2,ALOX15,THPO,CYP2D6,NFKB1,FFP,REP,MAPK1,EGFR,KDM4E,HPGD,LMNA,BLM,FTL,TGR,HSP90AA1,PMP22,POLB,AMPC,GMNN,ATM,
MTOR}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Transcription factor","Unclassified protein","Epigenetic regulator","Other nuclear protein",Protease,Kinase,Oxidoreductase,"Cytochrome P450",Aminoacyltransferase,"Nu
clear receptor",Transferase,Eraser,Hydrolase,"Metallo protease","Protein Kinase","Cysteine protease","Cytochrome P450 family 3","Cytochrome P450 family 2","Protein-glutamine glutamyl-transferase","Nuc
lear hormone receptor subfamily 1","Cytochrome P450 family 1","Lysine demethylase","Metallo protease MAE clan","TK protein kinase group","Cysteine protease CA clan","Cytochrome P450 family 3A","Cytoch
rome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 1A","Cytochrome P450 family 2D","CMGC protein kinase group","Jumonji domain-containing","Atypical protein ki
nase group","Metallo protease M34 family","Tyrosine protein kinase JakA family","Cysteine protease C1A family","Cytochrome P450 3A4","Cytochrome P450 2C9","Cytochrome P450 2C19","Nuclear hormone recep
tor subfamily 1 group F member 3","Cytochrome P450 1A1","Cytochrome P450 2D6","CMGC protein kinase MAPK family","Tyrosine protein kinase EGFR family","Atypical protein kinase PIKK family","CMGC protei
n kinase ERK1","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets","Eicosanoid turnover","Catalytic receptors","Cytochrome P450","2.3.2.- Aminoacyltransferases","Nuclear hormone receptors","Anti-infective targets","Kinases (
EC 2.7.x.x)","Chromatin modifying enzymes","Heat shock proteins",Lipoxygenases,"Receptor kinases","CYP3 family","CYP2 family: drug metabolising subset","2.3.2.13 Transglutaminases","1F. Retinoic acid-
related orphans","CYP1 family","Viral protein targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","1.14.11.- Histone demethylases","Prostaglandin synthases",Atypical,"TK: Tyrosine kinase","Corona
virus (CoV) proteins","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","Recepto
r tyrosine kinases (RTKs)","Other PIKK family kinases","FRAP subfamily","Janus kinase (JakA) family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{Metabolism,"Neuronal System",Disease,"Cell Cycle","Immune System","Cellular responses to external stimuli","Gene expression (Transcription)",Hemostasis,"Signal Transduction","DNA Repair","Vesicle-med
iated transport","Developmental Biology","Metabolism of lipids","Transmission across Chemical Synapses","Infectious disease","Cell Cycle Checkpoints","Cytokine Signaling in Immune system","Cellular re
sponses to stress","Biological oxidations","Metabolism of amino acids and derivatives","RNA Polymerase II Transcription","Platelet activation","signaling and aggregation","Innate Immune System","Signa
ling by GPCR",Mitotic,"DNA Double-Strand Break Repair","Membrane Trafficking","Nervous system development","Base Excision Repair","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotran
smitter receptors and postsynaptic signal transmission","Uptake and actions of bacterial toxins","G1/S DNA Damage Checkpoints","Interferon Signaling","Signaling by Interleukins","Cellular response to 
hypoxia","Phase I - Functionalization of compounds","Branched-chain amino acid catabolism","Generic Transcription Pathway","Platelet Aggregation (Plug Formation)","SARS-CoV Infections","Toll-like Rece
ptor Cascades","GPCR downstream signalling","M Phase","Homology Directed Repair","trans-Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","EGR2 and SOX10-mediated initiation of Schwann cell myel
ination","Resolution of Abasic Sites (AP sites)","Mitotic G1 phase and G1/S transition","Biosynthesis of DPA-derived SPMs","Activation of NMDA receptors and postsynaptic events","Uptake and function o
f anthrax toxins","p53-Dependent G1/S DNA damage checkpoint","Antiviral mechanism by IFN-stimulated genes","Interleukin-2 family signaling","Oxygen-dependent proline hydroxylation of Hypoxia-inducible
 Factor Alpha","Ethanol oxidation","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Transcriptional regulation by RUNX3","Interleukin-1 family signaling","SARS-CoV-2 
Infection","Toll Like Receptor 5 (TLR5) Cascade","G alpha (q) signalling events","Mitotic Metaphase and Anaphase","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Golgi A
ssociated Vesicle Biogenesis","G2/M Transition","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","G1/S Transition","Transcriptional Regulation by TP53","Biosynthesis of D
PAn-3 SPMs","Post NMDA receptor activation events","p53-Dependent G1 DNA Damage Response","ISG15 antiviral mechanism","Interleukin-15 signaling","Biosynthesis of maresins",Xenobiotics,"RUNX3 Regulates
 Immune Response and Cell Migration","Interleukin-1 signaling","SARS-CoV-2 Genome Replication and Transcription","MyD88 cascade initiated on plasma membrane","Gastrin-CREB signalling pathway via PKC a
nd MAPK","Biosynthesis of D-series resolvins","Mitotic Anaphase","HDR through Homologous Recombination (HRR)","Centrosome maturation","PCNA-Dependent Long Patch Base Excision Repair","Activation of th
e pre-replicative complex","Regulation of TP53 Activity","Biosynthesis of DPAn-3-derived maresins","Activation of AMPK downstream of NMDARs","Stabilization of p53","Biosynthesis of maresin-like SPMs",
"CYP2E1 reactions","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of DPAn-3-derived protectins and resolvins","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Replicatio
n of the SARS-CoV-2 genome","MAP kinase activation","EGFR Transactivation by Gastrin","Nuclear Envelope (NE) Reassembly","Homologous DNA Pairing and Strand Exchange","Loss of proteins required for int
erphase microtubule organization from the centrosome","Regulation of TP53 Expression and Degradation","Autodegradation of the E3 ubiquitin ligase COP1","MAPK targets/ Nuclear events mediated by MAP ki
nases","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","ERK/
MAPK targets","ERKs are inactivated"}

> <broad_targets>
{JAK1,JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{"ZM 39923 hydrochloride",1021868-92-7,1021868927,58753-54-1,58753541,"ZM 39923 HCl","jak3 inhibitor iv","ZM39923 hydrochloride","ZM39923 (hydrochloride)","ZM 39923","ZM39923 HCl",CHEMBL538798,"3-(ben
zyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one hydrochl","3(benzyl(isopropyl)amino)1(naphthalen2yl)propan1one hydrochl",T2460,"EMD 420121",1367,S8004,420121}

> <pdid>
PD048975

> <targets>
{"JAK Kinase",JAK,JAK3}

> <classes>
{JAK/STAT,Epigenetics,JAK/STAT Signaling,Stem Cell/Wnt}

> <pubchem_cids>
{176406,74765369}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 26  0  0  0  0            999 V2000
   11.4894   -2.2574    0.0000 H   0  3
    8.9894   -2.2574    0.0000 Cl  0  5
    6.4848   -8.2644    0.0000 C   0  0
    5.1873   -7.5117    0.0000 C   0  0
    5.1894   -6.0109    0.0000 N   0  0
    6.4889   -5.2601    0.0000 C   0  0
    6.4894   -3.7601    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2990   -5.2500    0.0000 Cl  0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 12  1  0
 26 20  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28368

> <plate>
Kinase v5-1

> <well>
J06

> <supplier_cmpd_name>
10-DEBC hydrochloride

> <ctcr_id>
3103

> <supplier_cmpd_id>
2558

> <smiles>
[H+].[Cl-].CCN(CC)CCCCN1c2ccccc2Oc3ccc(Cl)cc13

> <pd_targets>
{PIM1,KMT2A,MEN1}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,"Protein Kinase",Bromodomain,"CAMK protein kinase group","CAMK protein kinase PIM family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","PIM family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","FLT3 signaling in disease","Signaling by FLT3 ITD and TKD mutants","STAT5 activation downstream of FLT3 ITD
 mutants"}

> <broad_targets>
{PIM1}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{"0DEBC HYDROCHLORID","10-(4'-(N-Diethylamino)butyl)-2-chlorophenoxazine hydrochloride","10(4'(NDiethylamino)butyl)2chlorophenoxazine hydrochloride","10-DEBC HYDROCHLORIDE","10DEBC HYDROCHLORIDE","Akt
 Inhibitor X",925681-41-0,925681410,201788-90-1,201788901,"10-DEBC (hydrochloride)","10DEBC (hydrochloride)","Akt Inhibitor (10-NCP)","Akt Inhibitor (10NCP)",10-(4'-(n,10(4'(n,n-diethylamino)butyl)-2-
chlorophenoxa,ndiethylamino)butyl)2chlorophenoxa,"EMD 124020",2558,124020,"10-DEBC hydrochloride"}

> <pdid>
PD047288

> <targets>
{"Akt (Protein Kinase B)",PKB}

> <classes>
{}

> <pubchem_cids>
{74627774,16760284}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
    1.2947   -3.7531    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -3.9021   -3.7405    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2080   -5.9890    0.0000 N   0  0
   -5.2111   -7.4899    0.0000 C   0  0
   -3.9120   -8.2400    0.0000 C   0  0
   -3.9120   -9.7400    0.0000 C   0  0
   -5.2110  -10.4900    0.0000 C   0  0
   -5.2110  -11.9900    0.0000 Br  0  0
   -6.5101   -9.7400    0.0000 C   0  0
   -6.5101   -8.2400    0.0000 C   0  0
   -7.8092   -7.4900    0.0000 N   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0127   -6.0039    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 15  1  0
 21 22  1  0
 13 23  1  0
 23 24  2  0
 24 10  1  0
 24 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28369

> <plate>
Kinase v5-1

> <well>
J08

> <supplier_cmpd_name>
EO 1428

> <ctcr_id>
5232

> <supplier_cmpd_id>
2908

> <smiles>
Cc1ccccc1C(=O)c2ccc(Nc3ccc(Br)cc3N)cc2Cl

> <pd_targets>
{MAPK11,MAPK12,MAPK13,MAPK14}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK11,MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"EO 1428",321351-00-2,321351002,EO-1428,EO1428,UNII-MV2RHJ680O,UNIIMV2RHJ680O,MV2RHJ680O,CHEMBL347496,(4-(2-amino-4-bromoanilino)-2-chlorophenyl)-(2-methylphenyl)methanone,(4(2amino4bromoanilino)2chl
orophenyl)(2methylphenyl)methanone,(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)(2-methylphenyl)methanone,(4((2Amino4bromophenyl)amino)2chlorophenyl)(2methylphenyl)methanone,(4-((2-amino-4-bromoph
enyl)ami,(4((2amino4bromophenyl)ami,2908,"EMD 506163",506163}

> <pdid>
PD021755

> <targets>
{"MAPK Family","p38 MAPK","p38 MAP Kinase Inhibitor VIII"}

> <classes>
{}

> <pubchem_cids>
{9801969}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 22  0  0  0  0            999 V2000
   12.1347   -0.9886    0.0000 H   0  3
    9.6347   -0.9886    0.0000 Cl  0  5
    2.5983   -3.0004    0.0000 O   0  0
    2.5988   -1.5004    0.0000 S   0  0
    3.8975   -2.2510    0.0000 O   0  0
    3.8990   -0.7508    0.0000 N   0  0
    5.1522   -1.5883    0.0000 C   0  0
    6.5858   -1.1471    0.0000 C   0  0
    7.1347    0.2489    0.0000 C   0  0
    6.3855    1.5484    0.0000 N   0  0
    4.9024    1.7729    0.0000 C   0  0
    3.8022    0.7533    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  2  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  6  1  0
  4 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 13  1  0
 22 17  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28370

> <plate>
Kinase v5-1

> <well>
J10

> <supplier_cmpd_name>
Fasudil hydrochloride

> <ctcr_id>
4951

> <supplier_cmpd_id>
541

> <smiles>
[H+].[Cl-].O=[S](=O)(N1CCCNCC1)c2cccc3cnccc23

> <pd_targets>
{ROCK2,ROCK1,HTT,PRKCD,CDK8,PRKACA,RPS6KA3,AURKB,PRKX,PRKCG,PRKCE,CYP3A4,CYP2D6,PRKCQ,PRKD2,MAP4K4,LRRK2,DAPK3,PRKG1,PRKACB,PRKACG,PKN2,LEF,MYLK,KCNH2,SGK2,CDK5,PRKD3,CLK4,CDK7,RPS6KB1,KMT2A,MEN1,AKT1
,SMN1,AKT3,PKN1,CHEK2,STK33,CCR2,RPS6KA5,CCL2}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Ion channel","Epigenetic regulator","Membrane receptor",Kinase,"Cytochrome P450",Protease,"Voltage-gated ion channel",Reader,"Family A G protein-coupled receptor","Prot
ein Kinase","Cytochrome P450 family 3","Cytochrome P450 family 2","Metallo protease","Potassium channels",Bromodomain,"Methyl-lysine/arginine binding protein","Peptide receptor (family A GPCR)","AGC p
rotein kinase group","CMGC protein kinase group","Other protein kinase group","Cytochrome P450 family 3A","Cytochrome P450 family 2D","CAMK protein kinase group","STE protein kinase group","TKL protei
n kinase group","Metallo protease MAE clan","Voltage-gated potassium channel","Tudor domain","Chemokine receptor","AGC protein kinase DMPK family","AGC protein kinase PKC family","CMGC protein kinase 
CDK family","AGC protein kinase PKA family","AGC protein kinase RSK family","Other protein kinase AUR family","Cytochrome P450 3A4","Cytochrome P450 2D6","CAMK protein kinase PKD family","STE protein 
kinase STE20 family","TKL protein kinase LRRK family","CAMK protein kinase DAPK family","AGC protein kinase PKG family","AGC protein kinase PKN family","Metallo protease M34 family","CAMK protein kina
se MLCK family","AGC protein kinase SGK family","CMGC protein kinase CLK family","AGC protein kinase AKT family","CAMK protein kinase RAD53 family","CAMK protein kinase unique family","CC chemokine re
ceptor","AGC protein kinase ROCK subfamily","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDK8 subfamily","AGC protein kinase RSK subfamily","AGC protein kinase PKC alpha subfamily","A
GC protein kinase PKC eta subfamily","STE protein kinase MSN subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK7 subfamily","AGC protein kinase p70 subfamily","AGC protein kinase
 MSK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Catalytic receptors","Cytochrome P450","Voltage-gated ion channels","G protein-coupled receptors","AGC: Containing PKA",PKG,"PKC families","CM
GC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CYP3 family","CYP2 family: drug metabolising subset","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Steri
le 7","Sterile 11","Sterile 20 kinases","Potassium channels","Chemokine receptors","DMPK family","Protein kinase C (PKC) family","Cyclin-dependent kinase (CDK) family","Protein kinase A (PKA) family",
"RSK family","Other protein kinases","Protein kinase D (PKD) family","STE20 family","TKL: Tyrosine kinase-like","Death-associated kinase (DAPK) family","Protein kinase G (PKG) family","Protein kinase 
N (PKN) family","Myosin Light Chain Kinase (MLCK) family","Voltage-gated potassium channels","SGK family","CLK family","Akt (Protein kinase B","PKB) family","CAMK-like (CAMKL) family","CAMK-unique fam
ily","Rho kinase","Delta subfamily","CDK8 subfamily","RSK subfamily","Aurora kinase (Aur) family","Alpha subfamily","Eta subfamily","MSN subfamily","Leucine-rich repeat kinase (LRRK) family","CDK5 sub
family","CDK7 subfamily","p70 subfamily","CHK1 subfamily","MSK subfamily"}

> <pathway_reactome>
{"Developmental Biology","Gene expression (Transcription)","Signal Transduction",Disease,"Cell Cycle","Immune System","Neuronal System",Metabolism,"Cellular responses to external stimuli","Programmed 
Cell Death",Hemostasis,"Muscle contraction","Transport of small molecules","Metabolism of RNA","Nervous system development","RNA Polymerase II Transcription","Intracellular signaling by second messeng
ers","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Innate Immune System","Infectious disease","Transmission across Chemical Synapses","Metabolism of lipid
s","Biological oxidations","Signaling by GPCR","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases",Apoptosis,"Platelet homeostasis","Signaling by Rho GTPases","Cardiac conducti
on","Ion channel transport","MTOR signalling","Metabolism of non-coding RNA","Axon guidance","Generic Transcription Pathway","DAG and IP3 signaling","Signaling by NOTCH1 in Cancer","Mitotic G2-G2/M ph
ases","Toll-like Receptor Cascades","M Phase","Leishmania infection","Neurotransmitter receptors and postsynaptic signal transmission","Fcgamma receptor (FCGR) dependent phagocytosis","Biosynthesis of
 specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","GPCR downstream signalling","Sphingolipid metabolism","Cellular Senescence","Signaling by PTK6","Caspase activat
ion via extrinsic apoptotic signalling pathway","Nitric oxide stimulates guanylate cyclase","RHO GTPase Effectors","Uptake and actions of bacterial toxins","Phase 3 - rapid repolarisation","Stimuli-se
nsing channels","HIV Infection","mTORC1-mediated signalling","snRNP Assembly","GPCR ligand binding","Semaphorin interactions","Transcriptional Regulation by MECP2","CaM pathway","Signaling by NOTCH1 H
D+PEST Domain Mutants in Cancer","G2/M Transition","Toll Like Receptor 5 (TLR5) Cascade","Mitotic Metaphase and Anaphase","Leishmania parasite growth and survival","Glutamate binding","activation of A
MPA receptors and synaptic plasticity","Role of phospholipids in phagocytosis","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","G alpha (i) signalling events","Sphing
olipid de novo biosynthesis","Oxidative Stress Induced Senescence","PTK6 promotes HIF1A stabilization","Caspase activation via Dependence Receptors in the absence of ligand","cGMP effects","RHO GTPase
s activate PKNs","Uptake and function of anthrax toxins","RHO GTPases activate PAKs","Transcriptional Regulation by TP53","HIV Life Cycle","Class A/1 (Rhodopsin-like receptors)","Sema4D in semaphorin 
signaling","Regulation of MECP2 expression and activity","Calmodulin induced events","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Centrosome maturation","MyD88 cascade initiated on plasm
a membrane","Mitotic Anaphase","Anti-inflammatory response favouring Leishmania parasite infection","Trafficking of AMPA receptors","Biosynthesis of maresins",Xenobiotics,"Visual phototransduction","R
egulation of TP53 Activity","Late Phase of HIV Life Cycle","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Peptide ligand-binding receptors","Sema4D 
induced cell migration and growth-cone collapse","Loss of proteins required for interphase microtubule organization from the centrosome","MAP kinase activation","Separation of Sister Chromatids","ADOR
A2B mediated anti-inflammatory cytokines production","Trafficking of GluR2-containing AMPA receptors","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","The phototransduction cascade","Regulation
 of TP53 Activity through Phosphorylation","Transcription of the HIV genome","Regulation of TP53 Expression and Degradation","PKA-mediated phosphorylation of CREB","Chemokine receptors bind chemokines
","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases",Inactivation,"recovery and regulation of the phototransduction cascade","HIV Transcription Elongation","
Regulation of TP53 Degradation","PKA activation","CREB phosphorylation","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{PKIA,PRKACA,ROCK1,ROCK2}

> <broad_moa>
{"rho associated kinase inhibitor"}

> <synonyms>
{"ASUDIL (HA1077) HC","ASUDIL (HA 1077) HC","1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-,monohydrochloride","1H1,4Diazepine, hexahydro1(5isoquinolinylsulfonyl),monohydrochloride","1H 1","
4 Diazepine","hexahydro 1 (5 isoqui",541,S1573,"Fasudil hydrochloride","Fasudil (HA-1077) HCl"}

> <pdid>
PD001304

> <targets>
{Rho-kinases,ROCK,Autophagy}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{657249,163751}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 33  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 O   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -6.5025   -0.7576    0.0000 O   0  0
   -7.8026   -1.5057    0.0000 C   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -7.7985    2.9932    0.0000 C   0  0
   -9.0967    3.7462    0.0000 C   0  0
   -9.0947    5.2471    0.0000 N   0  0
  -10.3929    6.0001    0.0000 C   0  0
  -10.3908    7.5009    0.0000 C   0  0
  -11.6890    8.2540    0.0000 C   0  0
  -11.6891    9.7540    0.0000 C   0  0
  -12.9881   10.5040    0.0000 C   0  0
  -12.9851   12.0048    0.0000 O   0  0
  -11.6850   12.7530    0.0000 C   0  0
  -14.2872    9.7540    0.0000 C   0  0
  -15.5885   10.5017    0.0000 O   0  0
  -16.8865    9.7499    0.0000 C   0  0
  -14.2872    8.2540    0.0000 C   0  0
  -12.9881    7.5040    0.0000 C   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.0987    5.6236    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 20 23  2  0
 23 24  1  0
 24 25  1  0
 23 26  1  0
 26 27  2  0
 27 18  1  0
 13 28  1  0
 28 29  2  0
 29  8  1  0
  5 30  1  0
 30 31  2  0
 31  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28371

> <plate>
Kinase v5-1

> <well>
J12

> <supplier_cmpd_name>
SBE 13 hydrochloride

> <ctcr_id>
11415

> <supplier_cmpd_id>
4292

> <smiles>
Clc1ncc(COc2c(OC)cc(CNCCc3cc(OC)c(OC)cc3)cc2)cc1.Cl

> <pd_targets>
{FTL}

> <pathway_gtopdb>
{"Unclassified protein"}

> <pathway_chembl>
{}

> <pathway_reactome>
{"Vesicle-mediated transport","Membrane Trafficking","trans-Golgi Network Vesicle Budding","Golgi Associated Vesicle Biogenesis"}

> <broad_targets>
{PLK1}

> <broad_moa>
{"PLK inhibitor"}

> <synonyms>
{1052532-15-6,1052532156,"SBE13 hydrochloride","SBE 13 hydrochloride","SBE 13 HCl","SBE13 (Hydrochloride)","SBE-13 HCl","SBE13 HCl",MLS000538104,C24H27ClN2O4.ClH,"SBE-13 HCl;SBE13 HCl","SBE13 HCl;SBE1
3 HCl",CHEMBL1584055,SCHEMBL18797681,AOB6814,DTXSID10474576,EX-A81,EXA81,T2271}

> <pdid>
PD070066

> <targets>
{"Polo-like Kinase",PLK1,PLK2,PLK3,Apoptosis,Autophagy,"Polo-like Kinase (PLK)"}

> <classes>
{Cell Cycle/Checkpoint,Apoptosis,Autophagy,Cell Cycle/DNA Damage}

> <pubchem_cids>
{11948807}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
    7.7402   -4.0939    0.0000 C   0  0
    6.2484   -4.2507    0.0000 C   0  0
    5.4984   -5.5497    0.0000 N   0  0
    4.0312   -5.2378    0.0000 O   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.2447   -3.1359    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -3.8976   -0.7554    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 N   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
   -7.7912   -3.0067    0.0000 C   0  0
   -9.0907   -3.7559    0.0000 F   0  0
   -7.7908   -1.5067    0.0000 F   0  0
   -9.0900   -2.2562    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  5  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 14 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 23 25  1  0
 25 26  1  0
 25 27  1  0
 25 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28374

> <plate>
Kinase v5-1

> <well>
J18

> <supplier_cmpd_name>
T 5601640

> <ctcr_id>
11648

> <supplier_cmpd_id>
5269

> <smiles>
Cc1noc(c1)C(=O)Nc1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{LIMK2}

> <broad_moa>
{"LIM kinase inhibitor"}

> <synonyms>
{56LIMK,T56-LIMKi,T56LIMKi,924473-59-6,924473596,"T 5601640",T5601640,T-5601640,CHEMBL4303259,AOB6617,BCP28984,ZINC8312780,T-5601640T56-LIMKi,T5601640T56LIMKi,MFCD08495674,s6498,STL508162,AKOS00356016
4,CS-6384,CS6384,MCULE-9670023444,MCULE9670023444,"T56-LIMKi, >=98 (HPLC)","T56LIMKi, >=98 (HPLC)",NCGC00387256-02,NCGC0038725602,AK688822,BS-17991,BS17991,HY-,HY,T3960}

> <pdid>
PD038499

> <targets>
{LIMK,LIMK2}

> <classes>
{"Cell Cycle/Checkpoint"}

> <pubchem_cids>
{9438169}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    1.2873   -5.2494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    2.6160    7.4949    0.0000 N   0  0
    3.9072    5.2405    0.0000 C   0  0
    3.9020    3.7405    0.0000 C   0  0
    5.1985    2.9860    0.0000 Cl  0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 14 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 19 12  1  0
 10 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 23 27  1  0
 27 20  1  0
 27 28  2  0
 28  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28377

> <plate>
Kinase v5-1

> <well>
L04

> <supplier_cmpd_name>
Aminopurvalanol A

> <ctcr_id>
1611

> <supplier_cmpd_id>
2072

> <smiles>
CC(C)C(CO)Nc1nc(Nc2cc(N)cc(Cl)c2)c3ncn(C(C)C)c3n1

> <pd_targets>
{ALDH1A1,CDK5,MAPT,CYP3A4,CDK1,TSHR,CYP2C9,MAPK1,HPGD,CDK2,RORC,KDM4E,LEF,KMT2A,MEN1,CYP1A2,CCNB1,CCNB2,CCNB3,CLK1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Membrane receptor","Transcription factor","Epigenetic regulator",Oxidoreductase,Kinase,"Cytochrome P450","Family A G protein-coupled receptor","Nuclear receptor",Era
ser,Protease,Reader,"Protein Kinase","Cytochrome P450 family 3","Peptide receptor (family A GPCR)","Cytochrome P450 family 2","Nuclear hormone receptor subfamily 1","Lysine demethylase","Metallo prote
ase",Bromodomain,"Cytochrome P450 family 1","CMGC protein kinase group","Cytochrome P450 family 3A","Glycohormone receptor","Cytochrome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","
Jumonji domain-containing","Metallo protease MAE clan","Cytochrome P450 family 1A","CMGC protein kinase CDK family","Cytochrome P450 3A4","Cytochrome P450 2C9","CMGC protein kinase MAPK family","Nucle
ar hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Cytochrome P450 1A1","CMGC protein kinase CLK family","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDC2 su
bfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","Nuclear hormone receptors","Chromatin modifying enzymes","CMGC: Containing CDK",MAPK,GS
K3,"CLK families","CYP3 family","Glycoprotein hormone receptors","CYP2 family: drug metabolising subset","Prostaglandin synthases","1F. Retinoic acid-related orphans","1.14.11.- Histone demethylases",
"CYP1 family","Cyclin-dependent kinase (CDK) family","Mitogen-activated protein kinases (MAP kinases)","CLK family","CDK5 subfamily","CDK1 subfamily","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Gene expression (Transcription)","Neuronal System","Cell Cycle",Disease,"Immune System","Biological oxidations","RNA Polymerase II Transcription","Transmission across Chemical Synapses","
Metabolism of lipids",Mitotic,"Infectious disease","Innate Immune System","Phase I - Functionalization of compounds","Generic Transcription Pathway","Neurotransmitter receptors and postsynaptic signal
 transmission","Biosynthesis of specialized proresolving mediators (SPMs)","Regulation of mitotic cell cycle","Leishmania infection","Toll-like Receptor Cascades","Uptake and actions of bacterial toxi
ns","Ethanol oxidation","Transcriptional Regulation by TP53","Activation of NMDA receptors and postsynaptic events","Biosynthesis of DHA-derived SPMs","APC/C-mediated degradation of cell cycle protein
s","Leishmania parasite growth and survival","Cytochrome P450 - arranged by substrate type","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional regulation by RUNX3","Uptake and function of anthrax 
toxins","Regulation of TP53 Activity","Post NMDA receptor activation events","Biosynthesis of maresins","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Anti-inflammator
y response favouring Leishmania parasite infection",Xenobiotics,"MyD88 cascade initiated on plasma membrane","Biosynthesis of D-series resolvins","RUNX3 Regulates Immune Response and Cell Migration","
Regulation of TP53 Activity through Phosphorylation","Activation of AMPK downstream of NMDARs","Biosynthesis of maresin-like SPMs","APC/C:Cdc20 mediated degradation of mitotic proteins","ADORA2B media
ted anti-inflammatory cytokines production","CYP2E1 reactions","MAP kinase activation","Regulation of TP53 Expression and Degradation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Cdc
20:Phospho-APC/C mediated degradation of Cyclin A","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{CDK1,CDK2,CDK5}

> <broad_moa>
{"CDK inhibitor","tyrosine kinase inhibitor"}

> <synonyms>
{"NG 97",SCHEMBL21168739,K00613a,ZINC00582597,NCGC00390411-01,NCGC0039041101,J-014473,J014473,"EMD 164640",2072,164640,"Aminopurvalanol A"}

> <pdid>
PD005842

> <targets>
{"Cyclin-dependent Kinase",cdk}

> <classes>
{}

> <pubchem_cids>
{9549304}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 37  0  0  0  0            999 V2000
    2.4875    4.6307    0.0000 O   0  0
    1.0600    4.1700    0.0000 C   0  0
   -0.1700    5.0800    0.0000 N   0  0
   -1.4200    4.1700    0.0000 C   0  0
   -2.8476    4.6304    0.0000 O   0  0
   -0.9400    2.7100    0.0000 C   0  0
    0.5900    2.7000    0.0000 C   0  0
    1.3500    1.3600    0.0000 C   0  0
    2.8600    1.0300    0.0000 C   0  0
    4.1100    1.9400    0.0000 C   0  0
    5.5200    1.3100    0.0000 C   0  0
    5.6800   -0.2100    0.0000 C   0  0
    4.4200   -1.1200    0.0000 C   0  0
    3.0200   -0.4800    0.0000 C   0  0
    1.6000   -1.1100    0.0000 N   0  0
    1.0600   -2.5800    0.0000 C   0  0
    0.5600   -4.0500    0.0000 C   0  0
   -0.9400   -4.0500    0.0000 C   0  0
   -1.4100   -2.5800    0.0000 C   0  0
   -0.1700   -1.6900    0.0000 O   0  0
   -1.9800   -1.1000    0.0000 N   0  0
   -3.3900   -0.4700    0.0000 C   0  0
   -4.8000   -1.1000    0.0000 C   0  0
   -6.0500   -0.1900    0.0000 C   0  0
   -5.8800    1.3300    0.0000 C   0  0
   -4.4800    1.9600    0.0000 C   0  0
   -3.2300    1.0500    0.0000 C   0  0
   -1.7200    1.3700    0.0000 C   0  0
   -0.9500    0.0400    0.0000 C   0  0
    0.5600    0.0300    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 16  1  0
 19 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
 28  6  1  0
 28 29  2  0
 29 21  1  0
 29 30  1  0
 30  8  2  0
 30 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28378

> <plate>
Kinase v5-1

> <well>
L06

> <supplier_cmpd_name>
SB 218078

> <ctcr_id>
999

> <supplier_cmpd_id>
2560

> <smiles>
O=C1NC(=O)c2c1c3c4ccccc4n5C6CCC(O6)n7c8ccccc8c2c7c35

> <pd_targets>
{CDK2,CDK4,CHEK1,CCND1,KMT2A,MEN1,CCNE1,CCNE2,CDK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","Epigenetic regulator",Reader,Bromodomain,"CAMK protein kinase group",
"CAMK protein kinase CAMK1 family","CAMK protein kinase CHK1 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","CDK4 subfamily","CAMK: Calcium/calmodulin-dependent protein kin
ases","CAMK-like (CAMKL) family","CHK1 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","Transcriptional Regulation by TP53","G
1 Phase","Regulation of TP53 Activity","Cyclin D associated events in G1","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation","DNA Repair","DNA Double-Strand Break Repair"
,"Homology Directed Repair","Regulation of mitotic cell cycle","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","APC/C-mediated degradation of cell cycle proteins","HDR th
rough Homologous Recombination (HRR)","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Homologous DNA Pairing and Strand Exchange","APC/C:Cdc20 mediated degradation of m
itotic proteins","Presynaptic phase of homologous DNA pairing and strand exchange","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phos
pho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{CHEK1}

> <broad_moa>
{"CHK inhibitor"}

> <synonyms>
{"SB 218078",135897-06-2,135897062,SB-218078,SB218078,HSCI1_000147,HSCI1000147,HSCI1-000147,"HSCI1 000147",UNII-S6U3J3UP11,UNIIS6U3J3UP11,BDBM6763,CHEMBL304428,GTPL6037,S6U3J3UP11,SCHEMBL9224945,CHEBI
:91500,DTXSID10392024,HMS3229O08,HMS3269B11,HMS3413H07,HMS3677H07,BCP25033,EX-A4201,EXA4201,AKOS024457167,CCG-206880,CCG206880,"EMD 559402",2560,559402}

> <pdid>
PD004216

> <targets>
{"Checkpoint Kinases",Chk1,CHK1}

> <classes>
{}

> <pubchem_cids>
{3387354}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    3.9015    0.7475    0.0000 F   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    3.8919   -5.2525    0.0000 Cl  0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    3.9072    5.2405    0.0000 N   0  0
    3.9020    3.7405    0.0000 C   0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 11 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 19  1  0
 24 25  2  0
 25  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28379

> <plate>
Kinase v5-1

> <well>
L08

> <supplier_cmpd_name>
SD 208

> <ctcr_id>
757

> <supplier_cmpd_id>
3269

> <smiles>
Fc1ccc(Cl)cc1c2nc(Nc3ccncc3)c4nccnc4n2

> <pd_targets>
{TGFBR1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase STKR family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","Receptor serine/threonine kinase (RSTK) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by TGF-beta Receptor Complex in Cancer","Loss of Function of SMAD2/3 in Cancer","SMAD2/3 Phosphor
ylation Motif Mutants in Cancer"}

> <broad_targets>
{TGFBR1}

> <broad_moa>
{"TGF beta receptor inhibitor"}

> <synonyms>
{SD-208,SD208,627536-09-8,627536098,"SD 208",2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine,2(5chloro2fluorophenyl)N(pyridin4yl)pteridin4amine,2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylp
teridin-4-amine,2(5chloro2fluorophenyl)Npyridin4ylpteridin4amine,CHEMBL238125,MFCD11519969,2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl-amine,2(5Chloro2fluorophenyl)pteridin4yl)pyridin4ylamin
e,ALK5,T2109,3269}

> <pdid>
PD012771

> <targets>
{"TGF-beta Receptors","TGFbeta R1",TGFbR1,"TGF-² Receptor"}

> <classes>
{TGF-beta/Smad}

> <pubchem_cids>
{10316032}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -3.8813    1.4408    0.0000 C   0  0
   -5.0460    2.3579    0.0000 S   0  0
   -6.2823    1.5084    0.0000 C   0  0
   -7.6935    2.0116    0.0000 C   0  0
   -8.8360    1.0396    0.0000 N   0  0
   -7.9646    3.4869    0.0000 O   0  0
   -5.8565    0.0701    0.0000 C   0  0
   -6.7662   -1.1203    0.0000 O   0  0
   -6.1900   -2.5061    0.0000 C   0  0
   -7.1014   -3.6986    0.0000 C   0  0
   -8.5886   -3.5028    0.0000 C   0  0
   -9.5018   -4.6927    0.0000 C   0  0
   -8.9279   -6.0786    0.0000 C   0  0
   -7.4407   -6.2745    0.0000 C   0  0
   -6.5275   -5.0845    0.0000 C   0  0
   -5.0395   -5.2806    0.0000 C   0  0
   -4.4648   -6.6661    0.0000 F   0  0
   -4.1266   -4.0904    0.0000 F   0  0
   -3.5523   -5.4758    0.0000 F   0  0
   -4.3570    0.0307    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 11 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
 15 28  1  0
 28  9  2  0
  8 29  1  0
 29  5  2  0
 29 30  1  0
 30 31  2  0
 31  3  1  0
 31 32  1  0
 32 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28380

> <plate>
Kinase v5-1

> <well>
L10

> <supplier_cmpd_name>
GW 843682X

> <ctcr_id>
4653

> <supplier_cmpd_id>
2977

> <smiles>
COc1cc2ncn(c3sc(C(N)=O)c(OCc4ccccc4C(F)(F)F)c3)c2cc1OC

> <pd_targets>
{ITK,CLK4,BRSK1,PLK3,EGFR,NEK2,JAK2,SLK,PLK2,MELK,GSK3B,PLK4,FLT1,AXL,PLK1,KDR,KIT,MAP4K5,LCK,NTRK1,PTK2,RPS6KA3,MAPKAPK5,FGFR1,PDGFRB,CSF1R,AURKA,RPS6KA5,JAK3,ERBB2,TSSK1B,TSSK2,LIMK1,PRKX,FLT4,SRC,P
TK2B,PRKG1,DYRK1A,STK3,FLT3,MAP4K4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","CAMK protein kinase group","Other protein kinase group","STE protein kinase group","AGC protein kinase group","TK
L protein kinase group","Tyrosine protein kinase Tec family","CMGC protein kinase CLK family","CAMK protein kinase CAMK1 family","Other protein kinase PLK family","Tyrosine protein kinase EGFR family"
,"Other protein kinase NEK family","Tyrosine protein kinase JakA family","STE protein kinase STE20 family","CMGC protein kinase GSK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kin
ase Axl family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Trk family","Tyrosine protein kinase Fak family","AGC protein kinase RSK family","C
AMK protein kinase MAPKAPK family","Tyrosine protein kinase FGFR family","Other protein kinase AUR family","CAMK protein kinase TSSK family","TKL protein kinase LISK family","AGC protein kinase PKA fa
mily","AGC protein kinase PKG family","CMGC protein kinase DYRK family","CAMK protein kinase BRSK subfamily","STE protein kinase SLK subfamily","Other protein kinase PLK2","CAMK protein kinase MELK su
bfamily","STE protein kinase KHS subfamily","AGC protein kinase RSK subfamily","CAMK protein kinase MAPKAPK subfamily","AGC protein kinase MSK subfamily","TKL protein kinase LIMK subfamily","CMGC prot
ein kinase Dyrk1 subfamily","STE protein kinase MST subfamily","STE protein kinase MSN subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs o
f yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","TK: Tyrosine kinase","CLK family","CAMK-like (CAMKL) family","Other protein kinases","STE20 family","Glyc
ogen synthase kinase (GSK) family","RSK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Testis specific kinase (TSSK) family","TKL: Tyrosine kinase-like","Protein kinase A (PKA) family","Pro
tein kinase G (PKG) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Non-receptor tyrosine kinases (nRTKs)","BRSK subfamily","Polo-like kinase (PLK) family","Rec
eptor tyrosine kinases (RTKs)","NIMA (never in mitosis gene a)- related kinase (NEK) family","SLK subfamily","MELK subfamily","GSK subfamily","KHS subfamily","RSK subfamily","MAPKAPK subfamily","Auror
a kinase (Aur) family","MSK subfamily","LIM domain kinase (LISK) family","Dyrk1 subfamily","MST subfamily","MSN subfamily","Tec family","Type I RTKs: ErbB (epidermal growth factor) receptor family","J
anus kinase (JakA) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT
3 receptor family","Src family","Type VII RTKs: Neurotrophin receptor/Trk family","Fak family","Type V RTKs: FGF (fibroblast growth factor) receptor family","LIMK subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)","Signal Transduction","Cell Cycle",Disease,"Developmental Biology",Hemostasis,"Cellular responses to external stimuli","Adaptive Immune System","RNA 
Polymerase II Transcription","Signaling by GPCR",Mitotic,"Infectious disease","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers
","Innate Immune System","Intracellular signaling by second messengers","Cytokine Signaling in Immune system","Nervous system development","Platelet homeostasis","Signaling by Hippo","Cellular respons
es to stress","TCR signaling","Generic Transcription Pathway","GPCR downstream signalling","Regulation of mitotic cell cycle","Mitotic G1 phase and G1/S transition","Leishmania infection","SARS-CoV In
fections","Mitotic G2-G2/M phases","Signaling by VEGF","Signaling by KIT in disease","HIV Infection","Signaling by NTRKs","Toll-like Receptor Cascades","Signaling by FGFR in disease","PIP3 activates A
KT signaling","Signaling by Interleukins","Axon guidance","Nitric oxide stimulates guanylate cyclase","Signaling by Insulin receptor","Cellular Senescence","Generation of second messenger molecules","
Transcriptional Regulation by TP53","G alpha (q) signalling events","APC/C-mediated degradation of cell cycle proteins","G1 Phase","Leishmania parasite growth and survival","SARS-CoV-1 Infection","G2/
M Transition","VEGF ligand-receptor interactions","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","Host Interactions of HIV factors","Signaling by NTRK1 (TRKA)","Parasite infection","Toll Like
 Receptor 5 (TLR5) Cascade","Signaling by FGFR1 in disease","Negative regulation of the PI3K/AKT network","Transcriptional Regulation by VENTX","Interleukin-2 family signaling","Semaphorin interaction
s","cGMP effects","G0 and Early G1","Insulin receptor signalling cascade","Oxidative Stress Induced Senescence","Regulation of TP53 Activity","Gastrin-CREB signalling pathway via PKC and MAPK","Activa
tion of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Cyclin D associated events in G1","Anti-inflammatory response favouring Leishmania parasite infection","SARS-CoV-1 Genome Repli
cation and Transcription","Centrosome maturation","VEGF binds to VEGFR leading to receptor dimerization","VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","The role of Nef in HIV-
1 replication and disease pathogenesis","Signalling to ERKs","Leishmania phagocytosis","MyD88 cascade initiated on plasma membrane","FGFR1 mutant receptor activation",PI5P,"PP2A and IER3 Regulate PI3K
/AKT Signaling","Interleukin-15 signaling","Sema4D in semaphorin signaling","Interleukin-2 signaling","IRS-mediated signalling","Regulation of TP53 Activity through Phosphorylation","EGFR Transactivat
ion by Gastrin","APC/C:Cdc20 mediated degradation of mitotic proteins","CD163 mediating an anti-inflammatory response","Replication of the SARS-CoV-1 genome","Loss of proteins required for interphase 
microtubule organization from the centrosome","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Prolonged ERK activation events","FCGR3A-mediated phagoc
ytosis","MAP kinase activation","Signaling by activated point mutants of FGFR1","Sema4D induced cell migration and growth-cone collapse","ADORA2B mediated anti-inflammatory cytokines production","Sign
alling to RAS","PI3K Cascade","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Loss of Nlp from mitotic centrosomes","Nef Mediated CD4 Down-re
gulation","ARMS-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","APC-Cdc20 mediated degradation of Nek2A","CREB phosphorylation"}

> <broad_targets>
{PLK1,PLK3}

> <broad_moa>
{"PLK inhibitor"}

> <synonyms>
{GW843682X,660868-91-7,660868917,"GW 843682X",GW843682,GW-843682X,C22H18F3N3O4S,Kinome_3462,Kinome3462,Kinome-3462,"Kinome 3462","thiophene deriv., 20",MLS006010260,"BMCL191018 Compound 2",CHEMBL51449
9,SCHEMBL1286884,BDBM25120,CHEBI:91334,DTXSID80431373,BCPP000216,HMS3265C07,HMS3265C08,HMS,2977}

> <pdid>
PD003624

> <targets>
{"Polo-like Kinase",PLK}

> <classes>
{}

> <pubchem_cids>
{9826308}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.2948   -3.7517    0.0000 O   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
   -7.7912   -3.0068    0.0000 C   0  0
   -9.0915   -3.7547    0.0000 C   0  0
  -10.3894   -3.0027    0.0000 C   0  0
  -10.3870   -1.5027    0.0000 N   0  0
   -9.0868   -0.7547    0.0000 C   0  0
   -7.7889   -1.5067    0.0000 C   0  0
  -11.6896   -3.7506    0.0000 F   0  0
   -2.5952   -6.0101    0.0000 O   0  0
   -2.5973   -7.5110    0.0000 C   0  0
   -1.2991   -8.2641    0.0000 C   0  0
   -1.2991   -9.7641    0.0000 C   0  0
   -0.0001  -10.5141    0.0000 C   0  0
    1.2990   -9.7642    0.0000 C   0  0
    1.2991   -8.2642    0.0000 C   0  0
    0.0000   -7.5141    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 18 22  1  0
 11 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28381

> <plate>
Kinase v5-1

> <well>
L12

> <supplier_cmpd_name>
GSK2578215A

> <ctcr_id>
11417

> <supplier_cmpd_id>
4629

> <smiles>
c1cncc(c1)NC(=O)c1c(ccc(c1)c1cc(ncc1)F)OCc1ccccc1

> <pd_targets>
{LRRK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase LRRK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","Leucine-rich repeat kinase (LRRK) family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Non-Receptor Tyrosine Kinases","Signaling by PTK6","PTK6 promotes HIF1A stabilization"}

> <broad_targets>
{LRRK2}

> <broad_moa>
{"leucine rich repeat kinase inhibitor"}

> <synonyms>
{GSK2578215A,1285515-21-0,1285515210,GSK-2578215A,2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzamide,2(benzyloxy)5(2fluoropyridin4yl)N(pyridin3yl)benzamide,"LRRK2-kinase inhibitor","LRRK
2kinase inhibitor",UNII-Q641JSF42X,UNIIQ641JSF42X,"Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-","Benzamide, 5(2fluoro4pyridinyl)2(phenylmethoxy)N3pyridinyl",Q641JSF42X,CHEMBL2
204495,5-(,5(,T2240}

> <pdid>
PD012768

> <targets>
{"RIP kinase family","LRRK2 (G2019S)","LRRK2 (WT)",Autophagy,LRRK2,Mitophagy}

> <classes>
{Autophagy}

> <pubchem_cids>
{68107965}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 30  0  0  0  0            999 V2000
    8.8915   -3.0024    0.0000 Cl  0  0
    6.3915   -3.0024    0.0000 Cl  0  0
    2.5795   -7.5040    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.6011   -3.0008    0.0000 N   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -7.8069   -5.9860    0.0000 F   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -7.7966   -2.9860    0.0000 Cl  0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  1  0
 25 27  2  0
 27 20  1  0
 18 28  1  0
 28 14  1  0
 28 29  2  0
 29 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28387

> <plate>
Kinase v5-1

> <well>
N04

> <supplier_cmpd_name>
BIBX 1382 dihydrochloride

> <ctcr_id>
70

> <supplier_cmpd_id>
2416

> <smiles>
Cl.Cl.CN1CCC(CC1)Nc2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2

> <pd_targets>
{ERBB2,EGFR,HTT,HPGD}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Eicosanoid turnover","Receptor kinases","Prostaglandin synthases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growt
h factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction","Gene expression (Transcription)",Metabolism,"Nervous system development","Signaling by GPCR","RNA Polymerase II Transcription","Metabolism of lipids","A
xon guidance","GPCR downstream signalling","Generic Transcription Pathway","Biosynthesis of specialized proresolving mediators (SPMs)","Semaphorin interactions","G alpha (q) signalling events","Transc
riptional Regulation by MECP2","Biosynthesis of DHA-derived SPMs","Sema4D in semaphorin signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Regulation of MECP2 expression and activity","Bio
synthesis of D-series resolvins","Sema4D induced cell migration and growth-cone collapse","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR,ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{"BIBX 1382 DIHYDROCHLORIDE",1216920-18-1,1216920181,"Falnidamol dihydrochloride",DSSTox_CID_26307,DSSToxCID26307,DSSTox-CID-26307,"DSSTox CID 26307",DSSTox_RID_81528,DSSToxRID81528,DSSTox-RID-81528,"
DSSTox RID 81528",DSSTox_GSID_46307,DSSToxGSID46307,DSSTox-GSID-46307,"DSSTox GSID 46307",CAS-1216920-18-1,CAS1216920181,NCGC00161422-01,NCGC0016142201,BIBX1382Dihydrochloride,CHEMBL2136050,DTXSID0046
307,Tox21_111996,Tox21111996,Tox21-111996,"Tox21 111996",AKOS015,2416,"BIBX 1382 dihydrochloride"}

> <pdid>
PD012960

> <targets>
{EGFR}

> <classes>
{}

> <pubchem_cids>
{46861540}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    8.5623   -9.6094    0.0000 C   0  0
    7.0623   -9.6116    0.0000 O   0  0
    6.3091   -8.3134    0.0000 C   0  0
    7.0591   -7.0143    0.0000 C   0  0
    6.3090   -5.7153    0.0000 C   0  0
    4.8090   -5.7153    0.0000 C   0  0
    4.0591   -7.0144    0.0000 C   0  0
    4.8091   -8.3134    0.0000 C   0  0
    4.0561   -9.6117    0.0000 O   0  0
    2.5561   -9.6096    0.0000 C   0  0
    4.0559   -4.4171    0.0000 C   0  0
    4.8036   -3.1167    0.0000 O   0  0
    2.5551   -4.4192    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 N   0  0
   -0.2237   -5.5078    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
  6 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  2  0
 21 22  1  0
 22 14  2  0
 22 23  1  0
 23 24  1  0
 23 25  2  0
M  END
> <name>
UTKinase_V5

> <id>
28388

> <plate>
Kinase v5-1

> <well>
N06

> <supplier_cmpd_name>
TCS 359

> <ctcr_id>
5064

> <supplier_cmpd_id>
2591

> <smiles>
COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O

> <pd_targets>
{FLT3,KMT2A,MEN1,RECQL}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,"Protein Kinase",Bromodomain,"TK protein kinase group","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by Insulin receptor","Insulin receptor signalling cascade","IRS-mediated signalling","PI3K Cascade"}

> <broad_targets>
{FLT3}

> <broad_moa>
{"FLT3 inhibitor"}

> <synonyms>
{"TCS 359",301305-73-7,301305737,"301305 73 7","Flt-3 inhibitor","Flt3 inhibitor","Flt 3 inhibitor",TCS-359,TCS359,CHEMBL210833,MFCD00617269,"2-((3,4-Dimethoxybenzoyl)amino)-4,5,6,7-benzo(b)thiophene-
3-carboxamide","2((3,4Dimethoxybenzoyl)amino)4,5,6,7benzo(b)thiophene3carboxamide",2((3,4Dimethoxybenzoyl)amino)4,"EMD 343020",2591,343020}

> <pdid>
PD010262

> <targets>
{FLT3}

> <classes>
{}

> <pubchem_cids>
{1048845}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    3.9266   -5.8778    0.0000 C   0  0
    4.8090   -4.6648    0.0000 C   0  0
    6.3007   -4.8230    0.0000 C   0  0
    5.4181   -6.0356    0.0000 C   0  0
    4.2013   -3.2954    0.0000 N   0  0
    2.7345   -2.9814    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9504   -0.8818    0.0000 C   0  0
    4.4160    0.5441    0.0000 C   0  0
    3.4139    1.6603    0.0000 N   0  0
    5.8837    0.8539    0.0000 N   0  0
    6.8858   -0.2623    0.0000 C   0  0
    6.4202   -1.6882    0.0000 N   0  0
    4.9525   -1.9980    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17  8  1  0
 17 12  1  0
  7 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24  5  1  0
 24 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28389

> <plate>
Kinase v5-1

> <well>
N08

> <supplier_cmpd_name>
1-Naphthyl PP1

> <ctcr_id>
5645

> <supplier_cmpd_id>
3063

> <smiles>
CC(C)(C)n1nc(c2cccc3ccccc23)c4c(N)ncnc14

> <pd_targets>
{RIPK2,FYN,SRC,CSK,MAPK8,PRKD1,ABL1,CDK2,PLD2,PLD1,CSNK1D,LCK,PRKCE,CDPK1,CAMK2A}

> <pathway_gtopdb>
{Enzyme,Kinase,Hydrolase,"Protein Kinase","TKL protein kinase group","TK protein kinase group","CMGC protein kinase group","CAMK protein kinase group","CK1 protein kinase group","AGC protein kinase gr
oup","TKL protein kinase RIPK family","Tyrosine protein kinase Src family","Tyrosine protein kinase Csk family","CMGC protein kinase MAPK family","CAMK protein kinase PKD family","Tyrosine protein kin
ase Abl family","CMGC protein kinase CDK family","CK1 protein kinase CK1 family","AGC protein kinase PKC family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase SrcA","CMGC protein kinase 
JNK subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase PKC eta subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Glycerophospholipid turnover","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent pr
otein kinases","Phosphatidylcholine-specific phospholipase D","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","Mitogen-activated prote
in kinases (MAP kinases)","Protein kinase D (PKD) family","Cyclin-dependent kinase (CDK) family","Casein kinase 1 (CK1) family","Protein kinase C (PKC) family","CAMK2 family","Receptor interacting pro
tein kinase (RIPK) family","Non-receptor tyrosine kinases (nRTKs)","JNK subfamily","CDK1 subfamily","Eta subfamily","Src family","Csk family","Abl family"}

> <pathway_reactome>
{"Immune System",Disease,"Signal Transduction",Metabolism,"Gene expression (Transcription)","Cell Cycle","Neuronal System","Innate Immune System","Infectious disease","Signaling by Receptor Tyrosine K
inases","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","RNA Polymerase II Transcription",Mitotic,"Transmission across Chemical Synapses","Tol
l-like Receptor Cascades","HIV Infection","Signaling by NTRKs","Oncogenic MAPK signaling","Sphingolipid metabolism","Leishmania infection","Generic Transcription Pathway","Phospholipid metabolism","Mi
totic G2-G2/M phases","Fcgamma receptor (FCGR) dependent phagocytosis","Neurotransmitter receptors and postsynaptic signal transmission","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV
 factors","Signaling by NTRK1 (TRKA)","Signaling by RAS mutants","Sphingolipid de novo biosynthesis","Parasite infection","Transcriptional Regulation by TP53","Glycerophospholipid biosynthesis","G2/M 
Transition","Role of phospholipids in phagocytosis","Activation of NMDA receptors and postsynaptic events","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and diseas
e pathogenesis","Signalling to ERKs","Signaling downstream of RAS mutants","Leishmania phagocytosis","Regulation of TP53 Activity","Synthesis of PA","Centrosome maturation","Post NMDA receptor activat
ion events","MAP kinase activation","Nef and signal transduction","Signalling to RAS","FCGR3A-mediated phagocytosis","Regulation of TP53 Expression and Degradation","Loss of proteins required for inte
rphase microtubule organization from the centrosome","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","CREB1 phosphorylation through NMDA receptor-media
ted activation of RAS signaling","activated TAK1 mediates p38 MAPK activation","p38MAPK events","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Loss of Nlp fro
m mitotic centrosomes","Nef Mediated CD4 Down-regulation","Ras activation upon Ca2+ influx through NMDA receptor","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{SRC}

> <broad_moa>
{"SRC inhibitor"}

> <synonyms>
{"NAPHTHYL PP",221243-82-9,221243829,"1-NAPHTHYL PP1","1NAPHTHYL PP1",1-NA-PP1,1NAPP1,"1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1(tertButyl)3(naphthalen1yl)1Hpyrazolo(3
,4d)pyrimidin4amine","pp1 analog","4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo(3,4-d)pyrimidine","4Amino1tertbutyl3(1'naphthyl)pyrazolo(3,4d)pyrimidine",CHEMBL264406,CHEBI:52310,1-tert-butyl-3-naphth
ale,1tertbutyl3naphthale,3063,"1-Naphthyl PP1"}

> <pdid>
PD012665

> <targets>
{"Src Kinases",Src}

> <classes>
{Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{4877}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
   -0.4646   -9.3545    0.0000 O   0  5
    1.0278   -9.2037    0.0000 N   0  3
    1.9043  -10.4210    0.0000 O   0  0
    1.6423   -7.8372    0.0000 C   0  0
    0.8997   -6.5339    0.0000 S   0  0
    1.9143   -5.4464    0.0000 C   0  0
    1.6137   -3.9759    0.0000 S   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2566    0.5871    0.0000 O   0  0
    2.5987   -1.5004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.2766   -6.0429    0.0000 N   0  0
    3.1112   -7.5338    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13  8  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 17  1  0
 22 23  2  0
 23 14  1  0
  6 24  2  0
 24 25  1  0
 25  4  2  0
M  CHG  2   1  -1   2   1
M  END
> <name>
UTKinase_V5

> <id>
28390

> <plate>
Kinase v5-1

> <well>
N10

> <supplier_cmpd_name>
BI 78D3

> <ctcr_id>
44

> <supplier_cmpd_id>
3314

> <smiles>
[O-][N+](=O)c1sc(SC2=NNC(=O)N2c3ccc4OCCOc4c3)nc1

> <pd_targets>
{REP,MAPK9,MAPK8,MAPK10}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase JNK subfamily"}

> <pathway_chembl>
{"Other protein targets",Enzymes,"Anti-infective targets","Kinases (EC 2.7.x.x)","Viral protein targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Coronavirus (CoV) proteins","Mitogen-activated
 protein kinases (MAP kinases)","JNK subfamily"}

> <pathway_reactome>
{Disease,"Immune System","Infectious disease","Innate Immune System","SARS-CoV Infections","Toll-like Receptor Cascades","SARS-CoV-2 Infection","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-2 Genome
 Replication and Transcription","MyD88 cascade initiated on plasma membrane","Replication of the SARS-CoV-2 genome","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","Acti
vation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK8}

> <broad_moa>
{"JNK inhibitor"}

> <synonyms>
{BI-78D3,BI78D3,883065-90-5,883065905,"BI 78D3",CHEMBL508280,MLS006010634,SCHEMBL8187066,BDBM26057,CHEBI:94732,DTXSID10372629,EX-A970,EXA970,HMS3413H22,HMS3677H22,BCP17200,ANW-67494,ANW67494,BDBM50526
695,CCG-56351,CCG56351,MFCD01313575,s8201,ZINC12370057,AKOS016006596,CCG-268395,CCG268395,C,T6784,3314,nan,"JNK INHIBITOR X"}

> <pdid>
PD021753

> <targets>
{"MAPK Family",JNK}

> <classes>
{MAPK/ERK Pathway}

> <pubchem_cids>
{2747117}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
    6.3028   -4.8211    0.0000 C   0  0
    4.8111   -4.6641    0.0000 S   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.2948   -3.7517    0.0000 C   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    5.5231    4.9024    0.0000 F   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 10 20  2  0
 20  6  1  0
  5 21  2  0
 21 22  1  0
 22  3  2  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  2  0
 29 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28391

> <plate>
Kinase v5-1

> <well>
N12

> <supplier_cmpd_name>
ML 3403

> <ctcr_id>
3546

> <supplier_cmpd_id>
4586

> <smiles>
CSc1[nH]c(c2ccnc(NC(C)c3ccccc3)c2)c(n1)c4ccc(F)cc4

> <pd_targets>
{MAPK11,MAPK12,MAPK13,MAPK14}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{CYP3A4,MAPK11,MAPK12,MAPK14}

> <broad_moa>
{"MAP kinase inhibitor"}

> <synonyms>
{ML3403,"p38 MAP Kinase Inhibitor III",549505-65-9,549505659,"549505 65 9",ML-3403,"ML 3403",CHEMBL111364,581098-48-8,581098488,"581098 48 8",K00568a,"InSolution&trade; p38 MAP Kinase Inhibitor III",G
TPL6014,SCHEMBL2896072,ml-3043,ml3043,"ml 3043",S,"EMD 506121",506121}

> <pdid>
PD038522

> <targets>
{"MAPK Family"}

> <classes>
{}

> <pubchem_cids>
{6419739}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 30  0  0  0  0            999 V2000
   11.2962   -3.4661    0.0000 Cl  0  0
    8.7962   -3.4661    0.0000 Cl  0  0
    4.0462  -12.2198    0.0000 C   0  0
    4.7954  -10.9203    0.0000 C   0  0
    6.2954  -10.9199    0.0000 C   0  0
    5.5460  -12.2190    0.0000 C   0  0
    4.0450   -9.6205    0.0000 C   0  0
    2.5450   -9.6205    0.0000 C   0  0
    1.7951   -8.3214    0.0000 C   0  0
    2.5451   -7.0223    0.0000 C   0  0
    4.0452   -7.0225    0.0000 C   0  0
    4.7951   -8.3215    0.0000 C   0  0
    1.7974   -5.7210    0.0000 C   0  0
    0.2974   -5.7184    0.0000 O   0  0
    2.5497   -4.4224    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2121    3.8625    0.0000 C   0  0
    0.7463    5.2884    0.0000 C   0  0
   -0.7537    5.2860    0.0000 N   0  0
   -1.2149    3.8587    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  4  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 10 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 18  1  0
 23 24  2  0
 24 16  1  0
 20 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28394

> <plate>
Kinase v5-1

> <well>
N18

> <supplier_cmpd_name>
TC ASK 10

> <ctcr_id>
14769

> <supplier_cmpd_id>
4825

> <smiles>
Cl.Cl.CC(C)(C)c1ccc(cc1)C(=O)Nc2cn3cc(ccc3n2)n4ccnc4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HY-103258,"TC ASK 10","TC ASK 10"}

> <pdid>
PD046649

> <targets>
{ASK1,Apoptosis,MAP3K}

> <classes>
{Apoptosis,MAPK/ERK Pathway}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    7.7884    1.5181    0.0000 F   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
    0.6923    4.0811    0.0000 O   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -2.4133    1.7530    0.0000 C   0  0
   -3.8805    1.4409    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2089   -5.9859    0.0000 F   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15  9  2  0
 15 16  1  0
 16 17  2  0
 17  7  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
  5 26  1  0
 26 27  2  0
 27  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28396

> <plate>
Kinase v5-1

> <well>
P04

> <supplier_cmpd_name>
CGP 53353

> <ctcr_id>
175

> <supplier_cmpd_id>
2442

> <smiles>
Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc4ccc(F)cc4)cc1

> <pd_targets>
{RORC,EGFR,KMT2A,MEN1,PRKCB,FFP,SRC,MAPT,PRKCA,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,PDGFRA,PDGFRB}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator","Other cytosolic protein","Nuclear receptor",Kinase,Reader,Transferase,"Nuclear hormone receptor subfamily 1","Protein Kinase",Bromodomain,"Nuclea
r hormone receptor subfamily 1 group F","TK protein kinase group","AGC protein kinase group","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase EGFR family","AGC protein 
kinase PKC family","Tyrosine protein kinase Src family","Tyrosine protein kinase PDGFR family","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Catalytic receptors","Kinases (EC 2.7.x.x)","1F. Retinoic acid-related orphans","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","TK: Tyrosin
e kinase","Protein kinase C (PKC) family","Receptor tyrosine kinases (RTKs)","Alpha subfamily","Non-receptor tyrosine kinases (nRTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family","Sr
c family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Cell Cycle","Neuronal System","RNA Polymerase II Transcription","Signaling by GPCR",Mitotic,"Signaling by Receptor Tyrosine Kinases","Transmis
sion across Chemical Synapses","Generic Transcription Pathway","GPCR downstream signalling","M Phase","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Transcript
ional regulation by RUNX3","G alpha (q) signalling events","Mitotic Prophase","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","RUNX3 Regulates Immune Response and Ce
ll Migration","Gastrin-CREB signalling pathway via PKC and MAPK","Nuclear Envelope Breakdown","Signalling to ERKs","Post NMDA receptor activation events","EGFR Transactivation by Gastrin","Depolymeris
ation of the Nuclear Lamina","Signalling to RAS","Activation of AMPK downstream of NMDARs","p38MAPK events"}

> <broad_targets>
{EGFR,PRKCB}

> <broad_moa>
{"EGFR inhibitor","PKC inhibitor"}

> <synonyms>
{145915-60-2,145915602,"145915 60 2","CGP 53353",CGP-53353,CGP53353,"DAPH 2","5,6-BIS((4-FLUOROPHENYL)AMINO)-1H-ISOINDOLE-1,3(2H)-DIONE","5,6BIS((4FLUOROPHENYL)AMINO)1HISOINDOLE1,3(2H)DIONE",5,"6 BIS(
(4 FLUOROPHENYL)AMINO) 1H ISOINDOLE 1",3(2H),"EMD 539652",2442,539652}

> <pdid>
PD021711

> <targets>
{"Protein Kinase C",PKC}

> <classes>
{}

> <pubchem_cids>
{6711154}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 29  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 C   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -7.1998   -1.6833    0.0000 C   0  0
   -8.0836   -0.4712    0.0000 C   0  0
   -9.5751   -0.6304    0.0000 C   0  0
  -10.1830   -2.0016    0.0000 C   0  0
   -9.2994   -3.2138    0.0000 C   0  0
   -7.8079   -3.0546    0.0000 C   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -5.1376   -4.2063    0.0000 C   0  0
   -6.5079   -4.8163    0.0000 O   0  0
   -3.8385   -4.9563    0.0000 N   0  0
   -2.7238   -3.9526    0.0000 C   0  0
   -1.2566   -4.2643    0.0000 O   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
  9 16  2  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 16  1  0
 22 23  2  0
 23  7  1  0
 23 24  1  0
 24  5  1  0
 24 25  2  0
 25  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28397

> <plate>
Kinase v5-1

> <well>
P06

> <supplier_cmpd_name>
PD 407824

> <ctcr_id>
3182

> <supplier_cmpd_id>
2694

> <smiles>
Oc1ccc2[nH]c3cc(c4ccccc4)c5C(=O)NC(=O)c5c3c2c1

> <pd_targets>
{CHEK1,WEE1,CDK4,FTL,RORC,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,KMT2A,MEN1,FFP,ALD}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Transcription factor","Epigenetic regulator",Kinase,"Nuclear receptor",Reader,Transferase,"Protein Kinase","Nuclear hormone receptor subfamily 1",Bromodomain,"CAMK prot
ein kinase group","Other protein kinase group","CMGC protein kinase group","Nuclear hormone receptor subfamily 1 group F","AGC protein kinase group","CAMK protein kinase CAMK1 family","Other protein k
inase WEE family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase PKC family","CAMK protein kinase CHK1 subfamily","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Nuclear hormone receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CL
K families","1F. Retinoic acid-related orphans","CAMK-like (CAMKL) family","Other protein kinases","Cyclin-dependent kinase (CDK) family","CHK1 subfamily","WEE family","CDK4 subfamily"}

> <pathway_reactome>
{"DNA Repair","Cell Cycle","Vesicle-mediated transport","Gene expression (Transcription)","DNA Double-Strand Break Repair","Cell Cycle Checkpoints",Mitotic,"Membrane Trafficking","RNA Polymerase II Tr
anscription","Homology Directed Repair","G2/M Checkpoints","Mitotic G1 phase and G1/S transition","trans-Golgi Network Vesicle Budding","Generic Transcription Pathway","HDR through Homologous Recombin
ation (HRR) or Single Strand Annealing (SSA)","G2/M DNA damage checkpoint","G1 Phase","Golgi Associated Vesicle Biogenesis","Transcriptional regulation by RUNX3","HDR through Homologous Recombination 
(HRR)","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Cyclin D associated events in G1","RUNX3 Regulates Immune Response and Cell Migration","Homologous DNA Pairing and Strand Excha
nge","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{WEE1}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{622864-54-4,622864544,PD-407824,PD407824,"PD 407824","9-HYDROXY-4-PHENYLPYRROLO(3,4-C)CARBAZOLE-1,3(2H,6H)-DIONE","9HYDROXY4PHENYLPYRROLO(3,4C)CARBAZOLE1,3(2H,6H)DIONE","9-HYDROXY-4-PHENYL-6H-PYRROLO
(3,4-C)CARBAZOLE-1,3-DIONE","9HYDROXY4PHENYL6HPYRROLO(3,4C)CARBAZOLE1,3DIONE",PD0407824,CHEMBL214253,SCHEMBL6516584,DTXSID40402483,HMS3262B15,HMS3269N21,HMS341,2694}

> <pdid>
PD005968

> <targets>
{"Checkpoint Kinases",Chk1,"Checkpoint Kinase (Chk)",Wee1}

> <classes>
{Cell Cycle/DNA Damage}

> <pubchem_cids>
{4369491}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
   -5.3864   -6.7681    0.0000 O   0  0
   -3.9462   -7.1872    0.0000 C   0  0
   -3.5894   -8.6441    0.0000 O   0  0
   -2.8628   -6.1485    0.0000 C   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 C   0  0
   -3.2175   -4.6910    0.0000 C   0  0
   -4.6578   -4.2692    0.0000 C   0  0
   -5.1442   -2.8637    0.0000 C   0  0
   -6.6435   -2.9101    0.0000 C   0  0
   -7.0627   -4.3503    0.0000 C   0  0
   -5.8226   -5.1941    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 10  1  0
  7 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 15  1  0
 23 18  1  0
 21 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28398

> <plate>
Kinase v5-1

> <well>
P08

> <supplier_cmpd_name>
GSK 650394

> <ctcr_id>
1169

> <supplier_cmpd_id>
3572

> <smiles>
OC(=O)c1ccc(cc1C2CCCC2)c3c[nH]c4ncc(cc34)c5ccccc5

> <pd_targets>
{CAMKK2,SGK2,SGK1,AURKA}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","AGC protein kinase group","Other protein kinase CAMKK family","AGC protein kinase SGK family","Other protein kinase AUR family","Other pro
tein kinase Meta subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","Other protein kinases","SGK family","CAMKK family","Aurora kinase (Aur) fam
ily","Meta subfamily"}

> <pathway_reactome>
{"Neuronal System","Transport of small molecules","Gene expression (Transcription)","Transmission across Chemical Synapses","Ion channel transport","RNA Polymerase II Transcription","Neurotransmitter 
receptors and postsynaptic signal transmission","Stimuli-sensing channels","Generic Transcription Pathway","Activation of NMDA receptors and postsynaptic events","Transcriptional Regulation by TP53","
Post NMDA receptor activation events","Regulation of TP53 Activity","Activation of AMPK downstream of NMDARs","Regulation of TP53 Expression and Degradation","Regulation of TP53 Activity through Phosp
horylation","Regulation of TP53 Degradation"}

> <broad_targets>
{SGK1,SGK2}

> <broad_moa>
{"serum/glucocorticoid regulated kinase inhibitor"}

> <synonyms>
{"GSK 650394",890842-28-1,890842281,GSK650394,GSK-650394,"2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)benzoic acid","2cyclopentyl4(5phenyl1Hpyrrolo(2,3b)pyridin3yl)benzoic acid",UNII-56887
611DJ,UNII56887611DJ,CHEMBL558642,56887611DJ,"2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)benzoic acid.","2cyclopentyl4(5phenyl1Hpyrrolo(2,3b)pyridin3yl)benzoic acid.",2-Cyclopenty,2Cyclop
enty,T2622,3572,nan}

> <pdid>
PD003278

> <targets>
{"Other Kinases","Glucocorticoid Regulated Kinsase (SGK) Inhibitor",SGK,"Influenza Virus"}

> <classes>
{Anti-infection,Metabolic Enzyme/Protease}

> <pubchem_cids>
{25022668}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    8.1250   -8.9408    0.0000 O   0  0
    7.5170   -7.5696    0.0000 C   0  0
    6.0248   -7.4094    0.0000 C   0  0
    5.4165   -6.0373    0.0000 C   0  0
    4.8082   -4.6653    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    6.4437   -1.8466    0.0000 C   0  0
    7.3222   -3.0635    0.0000 C   0  0
    8.8153   -2.9121    0.0000 C   0  0
    9.6938   -4.1289    0.0000 C   0  0
   11.1864   -3.9798    0.0000 C   0  0
   12.0619   -5.1977    0.0000 C   0  0
   11.4449   -6.5649    0.0000 C   0  0
    9.9523   -6.7142    0.0000 C   0  0
    9.0768   -5.4962    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 N   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  3  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15  9  1  0
  8 16  2  0
 16 17  1  0
 17  6  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 16 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28399

> <plate>
Kinase v5-1

> <well>
P10

> <supplier_cmpd_name>
RWJ 67657

> <ctcr_id>
6291

> <supplier_cmpd_id>
2999

> <smiles>
OCCC#Cc1nc(c2ccc(F)cc2)c(n1CCCc3ccccc3)c4ccncc4

> <pd_targets>
{MAPK-1,MAPK14,MAPK11}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase ERK1","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK14,PTGS2}

> <broad_moa>
{"MAP kinase inhibitor"}

> <synonyms>
{WJ6765,RWJ-67657,RWJ67657,215303-72-3,215303723,"RWJ 67657","JNJ 3026582",C27H24FN3O,CHEMBL190333,SCHEMBL162010,DTXSID40175867,SYN1072,HMS3244I11,HMS3244I12,HMS3244J11,BCP01966,ZINC1546302,ABP000280,
BDBM50295553,AKOS024457373,RWJ-67657/RWJ67657,RWJ67657/RWJ67657,NCGC00241112-01,NCGC0024111201,N,SY-RWJ-67657}

> <pdid>
PD017418

> <targets>
{"p38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{3008319}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 32  0  0  0  0            999 V2000
    4.7578   -4.4622    0.0000 C   0  0
    3.3718   -5.0359    0.0000 C   0  0
    2.3980   -3.8950    0.0000 C   0  0
    3.1884   -2.6408    0.0000 C   0  0
    4.6405   -2.9668    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 N   0  0
    3.1884    2.6409    0.0000 C   0  0
    2.2737    3.8235    0.0000 C   0  0
    2.8432    5.2111    0.0000 C   0  0
    4.3298    5.4118    0.0000 C   0  0
    5.2468    4.2247    0.0000 C   0  0
    4.6773    2.8370    0.0000 C   0  0
    4.9024    6.7990    0.0000 O   0  0
    6.3901    6.9977    0.0000 C   0  0
    6.9645    8.3834    0.0000 C   0  0
    8.4517    8.5788    0.0000 C   0  0
    9.3646    7.3886    0.0000 C   0  0
    8.7903    6.0029    0.0000 C   0  0
    7.3031    5.8074    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000    3.0000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  1  1  0
  4  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  3
 10  6  1  0
  9 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  3
 14 15  1  0
 15 16  2  3
 16 11  1  0
 14 17  1  0
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  2  3
 21 22  1  0
 22 23  2  3
 23 18  1  0
  8 24  1  0
 24 25  2  3
 25 26  1  0
 26 27  2  3
 27  7  1  0
 24 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28400

> <plate>
Kinase v5-1

> <well>
P12

> <supplier_cmpd_name>
PCI 29732

> <ctcr_id>
13661

> <supplier_cmpd_id>
5012

> <smiles>
C1CCC(C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N

> <pd_targets>
{BTK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Tec family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Tec family"}

> <pathway_reactome>
{Disease,"Infectious disease","Leishmania infection","Parasite infection","Leishmania phagocytosis","FCGR3A-mediated phagocytosis"}

> <broad_targets>
{BTK}

> <broad_moa>
{"Bruton's tyrosine kinase (BTK) inhibitor"}

> <synonyms>
{CI2973,"PCI 29732",330786-25-9,330786259,PCI-29732,PCI29732,"1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine","1Cyclopentyl3(4phenoxyphenyl)1Hpyrazolo(3,4d)pyrimidin4amine",CHEM
BL2057912,"1-cyclopentyl-3-(4-phenoxyphenyl)pyrazolo(3,4-d)pyrimidin-4-amine","1cyclopentyl3(4phenoxyphenyl)pyrazolo(3,4d)pyrimidin4amine",4-amino-1-cyclopentyl-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4amin
o1cyclopentyl3(4phenoxyphenyl)1hpyrazolo(3,T4337}

> <pdid>
PD038510

> <targets>
{"Brutons Tyrosine Kinase (BTK)",BTK,Itk,BCRP,Btk}

> <classes>
{Angiogenesis,Membrane Transporter/Ion Channel,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{22347110}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    6.5031    0.7404    0.0000 O   0  0
    5.2066    1.4948    0.0000 C   0  0
    5.2121    2.9956    0.0000 C   0  0
    6.4271    3.8534    0.0000 C   0  0
    5.9659    5.2808    0.0000 C   0  0
    4.4659    5.2832    0.0000 C   0  0
    4.0000    3.8574    0.0000 S   0  0
    3.9046    0.7483    0.0000 N   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    3.8888   -5.2533    0.0000 C   0  0
    2.5875   -5.9994    0.0000 C   0  0
    5.1854   -6.0076    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  3  1  0
  2  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 13 15  1  0
 12 16  1  0
 16 17  2  0
 17  9  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 21 26  1  0
 26 27  1  0
 27 18  1  0
 27 28  2  0
M  END
> <name>
UTKinase_V5

> <id>
28401

> <plate>
Kinase v5-1

> <well>
P14

> <supplier_cmpd_name>
ML 281

> <ctcr_id>
12787

> <supplier_cmpd_id>
4880

> <smiles>
O=C(c1cccs1)Nc1ccc(C(C)C)cc1c1nc2c(cccc2)[nH]c1=O

> <pd_targets>
{STK33}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase unique family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","CAMK-unique family"}

> <pathway_reactome>
{}

> <broad_targets>
{STK33}

> <broad_moa>
{"serine/threonine kinase inhibitor"}

> <synonyms>
{ML281,1404437-62-2,1404437622,ML-281,"ML 281",CHEMBL2204239,N-(2-(3-oxo-4H-quinoxalin-2-yl)-4-propan-2-ylphenyl)-2-thiophenecarboxamide,N(2(3oxo4Hquinoxalin2yl)4propan2ylphenyl)2thiophenecarboxamide,
bg-stk33-59,bgstk3359,MLS003876599,BRD8942,EX-A996,EXA996,CHEBI:125325,BCP17565,BRD-8942,BDBM50400664,MFCD25976601,ZINC95561917,AKOS024458394,T3423}

> <pdid>
PD015882

> <targets>
{"Other Kinases",STK33}

> <classes>
{Proteases/Proteasome}

> <pubchem_cids>
{53377448}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 32  0  0  1  0            999 V2000
    6.2484   -4.2507    0.0000 C   0  0
    5.2447   -3.1359    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0  2  0  0  0
    4.0312   -5.2378    0.0000 O   0  0
    5.4984   -5.5497    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.4133    1.7530    0.0000 C   0  0
    1.8032    3.1233    0.0000 C   0  0
    0.3114    2.9665    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    2.5536    4.4230    0.0000 C   0  0
    4.0444    4.5346    0.0000 C   0  0
    4.6946    5.8864    0.0000 C   0  0
    3.8489    7.1253    0.0000 C   0  0
    2.3532    7.0124    0.0000 C   0  0
    1.7031    5.6606    0.0000 C   0  0
    3.8813    1.4408    0.0000 C   0  0
    4.4481    0.0574    0.0000 C   0  0
    5.9346   -0.1432    0.0000 C   0  0
    6.8516    1.0439    0.0000 C   0  0
    6.2821    2.4316    0.0000 C   0  0
    4.7955    2.6322    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  1  1  0
  3  6  1  6
  6  7  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  1  0
 13  9  1  0
 13 14  2  3
 14 15  1  0
 15 16  2  3
 16  8  1  0
 11 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 21  1  0
 21 22  2  3
 22 17  1  0
 10 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  3
 26 27  1  0
 27 28  2  3
 28 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28403

> <plate>
Kinase v5-1

> <well>
P18

> <supplier_cmpd_name>
AIM 100

> <ctcr_id>
13674

> <supplier_cmpd_id>
4946

> <smiles>
C1C[C@H](OC1)CNC2=C3C(=C(OC3=NC=N2)C4=CC=CC=C4)C5=CC=CC=C5

> <pd_targets>
{LCK,TNK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase Ack family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Src family","Ack family"}

> <pathway_reactome>
{Disease,"Infectious disease","HIV Infection","Host Interactions of HIV factors","The role of Nef in HIV-1 replication and disease pathogenesis","Nef-mediates down modulation of cell surface receptors
 by recruiting them to clathrin adapters","Nef Mediated CD4 Down-regulation"}

> <broad_targets>
{TNK2}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{IM10,AIM-100,AIM100,873305-35-2,873305352,"AIM 100",CHEMBL247070,"N-(((2S)-oxolan-2-yl)methyl)-5,6-diphenylfuro(2,3-d)pyrimidin-4-amine","N(((2S)oxolan2yl)methyl)5,6diphenylfuro(2,3d)pyrimidin4amine"
,MLS006010340,SCHEMBL2965872,"AIM 100;AIM100",DTXSID20467671,EX-A3635,EXA3635,3426AH,BDBM50204589,s2212,ZINC28879084,AKOS024458428,CS-0702,CS0702,NC,T5092}

> <pdid>
PD012604

> <targets>
{Ack1,ACK1}

> <classes>
{Neuroscience,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{11501591}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 25  0  0  1  0            999 V2000
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    0.0000   -1.5000    0.0000 C   0  0  1  0  0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.9815   -3.8184    0.0000 C   0  0
   -2.3518   -3.2082    0.0000 C   0  0  1  0  0  0
   -2.5085   -1.7165    0.0000 C   0  0  1  0  0  0
   -3.8925   -1.1379    0.0000 O   0  0
   -3.5653   -4.0899    0.0000 O   0  0
   -3.7124    4.0029    0.0000 O   0  0
   -3.1023    5.3733    0.0000 C   0  0
   -1.6105    5.2165    0.0000 O   0  0
    4.9133    0.6415    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 11 10  1  1
 11 12  1  0
 12  3  1  6
 12 13  1  0
 13  1  1  0
 13 14  2  3
 14 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  1  1
 15 18  1  6
  8 19  1  0
 19 20  1  0
 20 21  1  0
 21  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28404

> <plate>
Kinase v5-1

> <well>
P20

> <supplier_cmpd_name>
Lycorine hydrochloride

> <ctcr_id>
11402

> <supplier_cmpd_id>
L5139

> <smiles>
C1CN2Cc3cc4c(cc3[C@H]3[C@H]2C1=C[C@@H]([C@H]3O)O)OCO4.Cl

> <pd_targets>
{AMPC,PAX8,RORC,ALOX15,KDM4E,TDP1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Hydrolase,"Transcription factor","Epigenetic regulator","Nuclear receptor",Oxidoreductase,Eraser,"Nuclear hormone receptor subfamily 1","Lysine demethylase","Nuclear hor
mone receptor subfamily 1 group F","Jumonji domain-containing","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Eicosanoid turnover","Chromatin modifying enzymes","1F. Retinoic acid-related orphans",Lipoxygenases,"1.14.11.- Histone demethylases"}

> <pathway_reactome>
{"Gene expression (Transcription)",Metabolism,"DNA Repair","RNA Polymerase II Transcription","Metabolism of lipids","DNA Double-Strand Break Repair","Generic Transcription Pathway","Biosynthesis of sp
ecialized proresolving mediators (SPMs)","Nonhomologous End-Joining (NHEJ)","Transcriptional regulation by RUNX3","Biosynthesis of DPA-derived SPMs","RUNX3 Regulates Immune Response and Cell Migration
","Biosynthesis of DPAn-3 SPMs","Biosynthesis of DPAn-3-derived protectins and resolvins"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Lycorine hydrochloride",2188-68-3,2188683,"2188 68 3","Lycorine chloride","Licorin hydrochloride","Lycorine HCl","Lycorine (hydrochloride)",UNII-58F70VH0HS,UNII58F70VH0HS,"UNII 58F70VH0HS",58F70VH0H
S,MFCD00243111,Lycorine-chloride,Lycorinechloride,SCHEMBL8437600,CHEMBL2092590,DTXSID80944478,HY-N0289,HYN0289,"HY N0289",CL0,T2774}

> <pdid>
PD052913

> <targets>
{"peptidyl transferase center (PTC)",HCV}

> <classes>
{Microbiology&virology}

> <pubchem_cids>
{164943}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
   11.8130   -1.5268    0.0000 Cl  0  0
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5551   -4.4192    0.0000 N   0  0
    4.0559   -4.4171    0.0000 C   0  0
    4.8036   -3.1167    0.0000 O   0  0
    4.8090   -5.7153    0.0000 O   0  0
    6.3098   -5.7131    0.0000 C   0  0
    7.0629   -7.0113    0.0000 C   0  0
    8.5630   -7.0113    0.0000 C   0  0
    9.3130   -8.3103    0.0000 O   0  0
    8.5631   -9.6094    0.0000 C   0  0
    7.0631   -9.6094    0.0000 C   0  0
    6.3130   -8.3104    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 N   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -5.2007   -1.4909    0.0000 C   0  0
   -6.4972   -0.7365    0.0000 C   0  0
   -6.4920    0.7635    0.0000 C   0  0
   -5.1903    1.5090    0.0000 C   0  0
   -5.4967    2.9766    0.0000 C   0  0
   -6.9880    3.1385    0.0000 N   0  0
   -7.6028    1.7703    0.0000 N   0  0
   -9.0700    1.4667    0.0000 C   0  0
  -10.0689    2.5867    0.0000 C   0  0
  -11.5383    2.2848    0.0000 C   0  0
  -12.5345    3.4062    0.0000 C   0  0
  -12.0613    4.8297    0.0000 C   0  0
  -10.5920    5.1317    0.0000 C   0  0
  -10.1189    6.5551    0.0000 F   0  0
   -9.5959    4.0102    0.0000 C   0  0
   -3.8939    0.7546    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 10  1  0
  4 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 26  1  0
 30 31  1  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  1  0
 36 38  2  0
 38 32  1  0
 27 39  2  0
 39 23  1  0
 21 40  1  0
 40  3  2  0
 40 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28405

> <plate>
Kinase v5-2

> <well>
A03

> <supplier_cmpd_name>
BMS-599626

> <ctcr_id>
5583

> <supplier_cmpd_id>
S1056

> <smiles>
Cl.Cc1c(NC(=O)OCC2COCCN2)cn3ncnc(Nc4ccc5c(cnn5Cc6cccc(F)c6)c4)c13

> <pd_targets>
{EGFR,ERBB4,CYP3A4,ERBB2,CYP2C19,CYP2C9,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Cytochrome P450","Voltage-gated ion channel","Protein Kinase","Cytochrome P450 family 3","Cytochrome P450 family 2","Potassium channels","TK protein kinase group","Cytoch
rome P450 family 3A","Cytochrome P450 family 2C","Voltage-gated potassium channel","Tyrosine protein kinase EGFR family","Cytochrome P450 3A4","Cytochrome P450 2C19","Cytochrome P450 2C9"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Cytochrome P450","Voltage-gated ion channels","Receptor kinases","CYP3 family","CYP2 family: drug metabolising subset","Potassium channels","TK
: Tyrosine kinase","Voltage-gated potassium channels","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System",Metabolism,"Developmental Biology","Muscle contraction","Signaling by GPCR","Transmission across Chemical Synapses","Metabolism of lipids","Nervous system deve
lopment","Biological oxidations","Cardiac conduction","GPCR downstream signalling","Neurotransmitter receptors and postsynaptic signal transmission","Biosynthesis of specialized proresolving mediators
 (SPMs)","Axon guidance","Phase I - Functionalization of compounds","Phase 3 - rapid repolarisation","G alpha (q) signalling events","Activation of NMDA receptors and postsynaptic events","Biosynthesi
s of DHA-derived SPMs","Semaphorin interactions","Cytochrome P450 - arranged by substrate type","Gastrin-CREB signalling pathway via PKC and MAPK","Post NMDA receptor activation events","Biosynthesis 
of maresins","Sema4D in semaphorin signaling",Xenobiotics,"EGFR Transactivation by Gastrin","Long-term potentiation","Biosynthesis of maresin-like SPMs","Sema4D induced cell migration and growth-cone 
collapse","CYP2E1 reactions"}

> <broad_targets>
{EGFR,ERBB2,ERBB4}

> <broad_moa>
{"EGFR inhibitor","protein tyrosine kinase inhibitor"}

> <synonyms>
{MS59962,BCP01780,AK548044,FT-0771809,FT0771809,S1056,BMS-599626}

> <pdid>
PD021511

> <targets>
{EGFR(HER)}

> <classes>
{}

> <pubchem_cids>
{56603696}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    7.7996   -1.4883    0.0000 C   0  0
    6.4990   -0.7409    0.0000 O   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -6.4842    5.2598    0.0000 C   0  0
   -6.4790    6.7598    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 O   0  0
   -2.6109   -7.4988    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 18 20  1  0
 20 21  3  0
 12 22  2  0
 22  8  1  0
 22 23  1  0
 23 24  2  0
 24  6  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28406

> <plate>
Kinase v5-2

> <well>
A05

> <supplier_cmpd_name>
Erlotinib Hydrochloride

> <ctcr_id>
2421

> <supplier_cmpd_id>
S1023

> <smiles>
COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC

> <pd_targets>
{PIP4K2C,ERBB2,BRAF,EGFR,JAK2,FLT3,FLT4,FRK,CSNK1D,TUBA1A,MET,AURKC,FLT1,RPS6KA4,ABL1,ABL2,BLK,STK10,GAK,ALK,DMPK,COQ8A,CDC42BPG,PDGFRB,MAP2K5,EPHA7,KIT,EIF2AK4,RET,ULK3,MAP3K2,LTK,TYRO3,JAK3,SYK,EPHA
3,TIE1,MAPK4,PDGFRA,CIT,FGR,LYN,TNNI3K,LCK,MYLK2,RIPK2,BMP2K,COQ8B,ERBB4,KDR,EPHA6,PKN2,SRC,AAK1,MAP3K3,SBK1,YES1,CSNK1E,CAMK2D,ERBB3,EPHB6,STK17B,CSK,EPHB4,MKNK2,MAPK9,SRPK3,MAP3K19,SLK,AURKA,AURKB,A
XL,HIPK4,GRK4,DDR1,STK17A,LRRK2,CYP3A4,MKNK1,MAPK10,STK36,EPHA8,TNK1,HCK,PLK4,MERTK,TNIK,TXK,TTK,LMNA,MINK1,SLCO2B1,DAPK3,TYK2,TBK1,DYRK2,PTK2,ABCG2,EIF2AK2,SIK2,RIPK4,EPHB1,EPHA5,ABCC2,ABCB1,RAF1,FGF
R2,PRKD2,SLC22A1,SLCO1B3,SLCO1B1,NR1I2}

> <pathway_gtopdb>
{Enzyme,"Structural protein","Unclassified protein","Other nuclear protein",Transporter,"Transcription factor",Transferase,Kinase,"Cytochrome P450","Electrochemical transporter","Primary active transp
orter","Nuclear receptor","Protein Kinase","Cytochrome P450 family 3","SLC superfamily of solute carriers","ATP-binding cassette","Nuclear hormone receptor subfamily 1","TK protein kinase group","TKL 
protein kinase group","CK1 protein kinase group","Other protein kinase group","AGC protein kinase group","STE protein kinase group","Atypical protein kinase group","CMGC protein kinase group","CAMK pr
otein kinase group","Cytochrome P450 family 3A","SLC21/SLCO family of organic anion transporting polypeptides","ABCG subfamily","ABCC subfamily","ABCB subfamily","SLC22 family of organic cation and an
ion transporters","Nuclear hormone receptor subfamily 1 group I","Tyrosine protein kinase EGFR family","TKL protein kinase RAF family","Tyrosine protein kinase JakA family","Tyrosine protein kinase PD
GFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src family","CK1 protein kinase CK1 family","Tyrosine protein kinase Met family","Other protein kinase AUR family","AGC prot
ein kinase RSK family","Tyrosine protein kinase Abl family","STE protein kinase STE20 family","Other protein kinase NAK family","TKL protein kinase STKR family","AGC protein kinase DMPK family","STE p
rotein kinase STE7 family","Tyrosine protein kinase Eph family","Other protein kinase PEK family","Tyrosine protein kinase Ret family","Other protein kinase ULK family","STE protein kinase STE11 famil
y","Tyrosine protein kinase Alk family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Syk family","Tyrosine protein kinase Tie family","CMGC protein kinase MAPK family","TKL protein ki
nase MLK family","CAMK protein kinase MLCK family","TKL protein kinase RIPK family","Atypical protein kinase ABC1 family","AGC protein kinase PKN family","Other protein kinase NKF1 family","CAMK prote
in kinase CAMK2 family","CAMK protein kinase DAPK family","Tyrosine protein kinase Csk family","CAMK protein kinase MAPKAPK family","CMGC protein kinase SRPK family","CMGC protein kinase DYRK family",
"AGC protein kinase GRK family","Tyrosine protein kinase DDR family","TKL protein kinase LRRK family","Cytochrome P450 3A4","Tyrosine protein kinase Ack family","Other protein kinase PLK family","Tyro
sine protein kinase Tec family","Other protein kinase TTK family","Other protein kinase IKK family","Tyrosine protein kinase Fak family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase FGF
R family","CAMK protein kinase PKD family","Nuclear hormone receptor subfamily 1 group I member 2","AGC protein kinase MSK subfamily","STE protein kinase SLK subfamily","TKL protein kinase STKR Type 1
 subfamily","AGC protein kinase GEK subfamily","Other protein kinase GCN2 subfamily","STE protein kinase MEKK2","CMGC protein kinase ERK3","AGC protein kinase CRIK subfamily","TKL protein kinase HH498
 subfamily","Atypical protein kinase ABC1-A subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase JNK subfamily","CMGC protein kinase HIPK subfamily","AGC protein kinase GRK subfamily","
STE protein kinase MSN subfamily","CMGC protein kinase Dyrk2 subfamily","Other protein kinase PKR","CAMK protein kinase QIK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets",Transporters,"Kinases (EC 2.7.x.x)","Catalytic receptors",Tubulins,"Cytochrome P450","SLC superfamily of solute carriers","ATP-binding cassette transporter f
amily","Nuclear hormone receptors","Lipid modifying kinases","Receptor kinases","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile
 20 kinases",Atypical,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","CYP3 family","SLCO family of organic anion transporting polypeptides","ABCG 
subfamily","ABCC subfamily","ABCB subfamily","SLC22 family of organic cation and anion transporters","1I. Vitamin D receptor-like receptors","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-
kinase family)","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Casein kinase 1 (CK1) family","Other protein kinases","RSK family","STE20 family","DMPK family","ABC1 family","STE7 family","STE11 fa
mily","Mitogen-activated protein kinases (MAP kinases)","Myosin Light Chain Kinase (MLCK) family","Protein kinase N (PKN) family","CAMK2 family","Death-associated kinase (DAPK) family","MAPK-Activated
 Protein Kinase (MAPKAPK) family","SRPK family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","G protein-coupled receptor kinases (GRKs)","CAMK-like (CAMKL) family","P
rotein kinase D (PKD) family","Organic cation transporters (OCT)","Receptor tyrosine kinases (RTKs)","RAF family","Non-receptor tyrosine kinases (nRTKs)","Aurora kinase (Aur) family","MSK subfamily","
SLK subfamily","Numb-associated kinase (NAK) family","GEK subfamily","ABC1-B subfamily","PEK family","Unc-51-like kinase (ULK) family","ERK subfamily","Other DMPK family kinases","Mixed Lineage Kinase
 (MLK) family","Receptor interacting protein kinase (RIPK) family","NAK family","NKF1 family","MKN subfamily","JNK subfamily","STE20 subfamily","HIPK subfamily","GRK4 subfamily","Leucine-rich repeat k
inase (LRRK) family","Polo-like kinase (PLK) family","MSN subfamily","TTK family","IKK family","Dyrk2 subfamily","QIK subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Janus ki
nase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Src family","Type X RTKs: HGF (hepatocyte growth f
actor) receptor family","Abl family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XIII RTKs: Ephrin receptor family","GCN2 subfamily","Type XIV RTKs: RET","Type XI RTKs: TAM 
(TYRO3-","AXL- and MER-TK) receptor family","Syk family","Type XII RTKs: TIE family of angiopoietin receptors","HH498 subfamily","Csk family","Type XVI RTKs: DDR (collagen receptor) family","Ack famil
y","Tec family","Fak family","Other PEK family kinases","Type V RTKs: FGF (fibroblast growth factor) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Developmental Biology","Signal Transduction","Cell Cycle",Disease,"Immune System","Vesicle-mediated transport","Muscle contraction","Cellular responses to external 
stimuli","Neuronal System","Extracellular matrix organization",Metabolism,Hemostasis,"Transport of small molecules","Programmed Cell Death","Metabolism of proteins","RNA Polymerase II Transcription","
Nervous system development","Signaling by Receptor Tyrosine Kinases","Signaling by GPCR",Mitotic,"Intracellular signaling by second messengers","Infectious disease","Innate Immune System","Membrane Tr
afficking","Cardiac conduction","Diseases of signal transduction by growth factor receptors and second messengers","Cellular responses to stress","Signaling by Hedgehog","Cytokine Signaling in Immune 
system","MAPK family signaling cascades","Signaling by Rho GTPases","Transmission across Chemical Synapses","Non-integrin membrane-ECM interactions","Signaling by Non-Receptor Tyrosine Kinases","Metab
olism of lipids","Cell surface interactions at the vascular wall","SLC-mediated transmembrane transport",Apoptosis,"Abacavir transport and metabolism","Disorders of transmembrane transporters","Post-t
ranslational protein modification","Generic Transcription Pathway","Axon guidance","Signaling by NTRKs","GPCR downstream signalling","Mitotic G1 phase and G1/S transition","Signaling by Insulin recept
or","Signaling by VEGF","PIP3 activates AKT signaling","Mitotic G2-G2/M phases","Leishmania infection","Neutrophil degranulation","trans-Golgi Network Vesicle Budding","Ion homeostasis","Signaling by 
KIT in disease","Response of EIF2AK4 (GCN2) to amino acid deficiency","Hedgehog 'on' state","Signaling by Interleukins","MAPK6/MAPK4 signaling","Signaling by PDGFR in disease","RHO GTPase Effectors","
HIV Infection","Toll-like Receptor Cascades","Neurotransmitter receptors and postsynaptic signal transmission","Clathrin-mediated endocytosis","Oncogenic MAPK signaling","M Phase","Signaling by PTK6",
"Biosynthesis of specialized proresolving mediators (SPMs)","Signaling by FGFR","Cellular Senescence","Fc epsilon receptor (FCERI) signaling","Transport of vitamins",nucleosides,"and related molecules
","Caspase activation via extrinsic apoptotic signalling pathway","Interferon Signaling","Abacavir transmembrane transport","Influenza Infection","ABC transporter disorders","MAPK1/MAPK3 signaling","S
ignaling by FGFR in disease","Sphingolipid metabolism","Transport of bile salts and organic acids","metal ions and amine compounds","Metabolism of steroids",SUMOylation,"Transcriptional Regulation by 
TP53","Semaphorin interactions","Signaling by NTRK1 (TRKA)","G alpha (q) signalling events","G1 Phase","Insulin receptor signalling cascade","VEGF ligand-receptor interactions","PTEN Regulation","G2/M
 Transition","L1CAM interactions","Parasite infection","Signaling by ROBO receptors","Transcriptional regulation by RUNX1","Golgi Associated Vesicle Biogenesis","Negative regulation of the PI3K/AKT ne
twork","EPH-Ephrin signaling","Drug resistance of KIT mutants","RET signaling","Interleukin-2 family signaling","Leishmania parasite growth and survival","Drug resistance of PDGFR mutants","RHO GTPase
s activate CIT","Host Interactions of HIV factors","Toll Like Receptor 5 (TLR5) Cascade","Activation of NMDA receptors and postsynaptic events","VEGFA-VEGFR2 Pathway","RHO GTPases activate PKNs","Carg
o recognition for clathrin-mediated endocytosis","Interleukin-1 family signaling","Signaling by RAS mutants","Mitotic Metaphase and Anaphase","G alpha (i) signalling events","PTK6 promotes HIF1A stabi
lization","Biosynthesis of DHA-derived SPMs","Signaling by FGFR4","Oxidative Stress Induced Senescence","FCERI mediated Ca+2 mobilization","Transport of organic anions","Caspase activation via Depende
nce Receptors in the absence of ligand","Interferon alpha/beta signaling","Toll Like Receptor 4 (TLR4) Cascade","NS1 Mediated Effects on Host Pathways","Defective ABCC2 causes DJS","RAF/MAP kinase cas
cade","Signaling by FGFR2 in disease","Sphingolipid de novo biosynthesis","Organic cation/anion/zwitterion transport","Bile acid and bile salt metabolism","SUMO E3 ligases SUMOylate target proteins","
Regulation of TP53 Activity","Sema4D in semaphorin signaling","Signalling to ERKs","Gastrin-CREB signalling pathway via PKC and MAPK","Cyclin D associated events in G1","IRS-mediated signalling","VEGF
 binds to VEGFR leading to receptor dimerization","Regulation of PTEN stability and activity","Centrosome maturation","Recycling pathway of L1","Leishmania phagocytosis","Role of ABL in ROBO-SLIT sign
aling","RUNX1 regulates transcription of genes involved in BCR signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signalling to ERK5","EPHA-mediated growth cone collapse","Dasatinib-resistan
t KIT mutants","Interleukin-15 signaling","Anti-inflammatory response favouring Leishmania parasite infection","Imatinib-resistant PDGFR mutants","The role of Nef in HIV-1 replication and disease path
ogenesis","MyD88 cascade initiated on plasma membrane","Post NMDA receptor activation events","VEGFR2 mediated cell proliferation","Interleukin-1 signaling","EPHB-mediated forward signaling","Signalin
g downstream of RAS mutants","Mitotic Anaphase","Visual phototransduction","Biosynthesis of maresins","Negative regulation of FGFR4 signaling","Regulation of IFNA signaling","MyD88-independent TLR4 ca
scade","Inhibition of PKR","Negative regulation of MAPK pathway","FGFR2 mutant receptor activation","Organic cation transport","Recycling of bile acids and salts","SUMOylation of intracellular recepto
rs","Regulation of TP53 Activity through Acetylation","Sema4D induced cell migration and growth-cone collapse","Prolonged ERK activation events","EGFR Transactivation by Gastrin","PI3K Cascade","Loss 
of proteins required for interphase microtubule organization from the centrosome","Sema4D mediated inhibition of cell attachment and migration","FCGR3A-mediated phagocytosis","FCGR3A-mediated IL10 syn
thesis","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","MAP kinase activation","Long-term potentiation","Signalling to RAS","CREB1 phosphorylation thr
ough NMDA receptor-mediated activation of RAS signaling","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids","The phototransduction cascade","Biosynthesis of maresi
n-like SPMs","Spry regulation of FGF signaling","Nef and signal transduction","Nuclear Envelope (NE) Reassembly","TRIF(TICAM1)-mediated TLR4 signaling","Negative feedback regulation of MAPK pathway","
Activated point mutants of FGFR2","PI5P Regulates TP53 Acetylation","ARMS-mediated activation","Loss of Nlp from mitotic centrosomes","Nef Mediated CD4 Down-regulation","activated TAK1 mediates p38 MA
PK activation","p38MAPK events","Ras activation upon Ca2+ influx through NMDA receptor","MAPK targets/ Nuclear events mediated by MAP kinases",Inactivation,"recovery and regulation of the phototransdu
ction cascade","Initiation of Nuclear Envelope (NE) Reformation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{EGFR,NR1I2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{HMS3244N19,Erlotinib,183321-74-6,183321746,"N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine","N(3Ethynylphenyl)6,7bis(2methoxyethoxy)quinazolin4amine","Erlotinib free base","4-((3-Ethy
nylphenyl)amino)-6,7-bis(2-methoxyethoxy)quinazoline","4((3Ethynylphenyl)amino)6,7bis(2methoxyethoxy)quinazoline",OSI-774,OSI774,4-Quinazolinamine,4Quinazolinamine,N-(3-ethynylphenyl)-6,N(3ethynylphen
yl)6,7-bis(2-me,7bis(2me,T0373,S1023,Prestw-1242,"Erlotinib Hydrochloride",ERLOTINIB}

> <pdid>
PD003356

> <targets>
{EGFR(HER),EGFR}

> <classes>
{}

> <pubchem_cids>
{176870}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0875    3.7680    0.0000 F   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Cl  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 N   0  0
   -3.9099   -8.2497    0.0000 C   0  0
   -3.9099   -9.7497    0.0000 C   0  0
   -2.6109  -10.4997    0.0000 O   0  0
   -1.3119   -9.7497    0.0000 C   0  0
   -1.3118   -8.2497    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 16 18  2  0
 18 11  1  0
  9 19  2  0
 19  5  1  0
 19 20  1  0
 20 21  2  0
 21  3  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28407

> <plate>
Kinase v5-2

> <well>
A07

> <supplier_cmpd_name>
Gefitinib(Iressa)

> <ctcr_id>
6466

> <supplier_cmpd_id>
S1025

> <smiles>
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCOCC4

> <pd_targets>
{FLT3,EGFR,ERBB2,MAPK9,LCK,SLK,STK10,SBK1,RIPK2,GAK,MKNK1,NLK,HCK,SIK2,MAPK4,PRKD2,PRKD3,LIMK1,PHKG1,TNIK,CAMK2G,KIT,EPHB1,TUBA1A,CSNK1E,STK17B,PIM1,PIM3,MAP4K5,ERBB3,ERBB4,CHEK2,MKNK2,LYN,MYLK2,SRC,S
TK17A,DMPK,IRAK4,AXL,BLK,BRAF,RPS6KA4,EPHA8,TXK,KDR,ABL1,IRAK1,MAP3K3,MAP3K2,MAPK10,MAPK14,HIPK4,ABL2,NUAK2,IRAK3,RET,BACE1,PIP4K2C,DCLK3,EPHA5,CIT,MINK1,CDK7,NORA,FLT4,MET,CAMK2D,PHKG2,ABCB11,LTK,MAP
T,FRK,EPHA6,STK36,EPHA1,MAPK6,MAP3K19,MAP2K5,EPHB4,CSNK1D,DAPK3,TNK2,EPHA3,FGR,PTK6,PRKD1,EPHB6,ULK3,MAP4K4,EPHA7,BRSK1,ABCG2,ABCC4}

> <pathway_gtopdb>
{Enzyme,"Structural protein","Unclassified protein",Transporter,"Other cytosolic protein",Kinase,Protease,Transferase,"Primary active transporter","Protein Kinase","Cysteine protease","Aspartic protea
se","ATP-binding cassette","TK protein kinase group","CMGC protein kinase group","STE protein kinase group","Other protein kinase group","TKL protein kinase group","CAMK protein kinase group","Cystein
e protease CA clan","CK1 protein kinase group","AGC protein kinase group","Aspartic protease AA clan","ABCB subfamily","ABCG subfamily","ABCC subfamily","Tyrosine protein kinase PDGFR family","Tyrosin
e protein kinase EGFR family","CMGC protein kinase MAPK family","Tyrosine protein kinase Src family","STE protein kinase STE20 family","Other protein kinase NKF1 family","TKL protein kinase RIPK famil
y","Other protein kinase NAK family","CAMK protein kinase MAPKAPK family","CAMK protein kinase CAMK1 family","CAMK protein kinase PKD family","TKL protein kinase LISK family","CAMK protein kinase PHk 
family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Eph family","Cysteine protease C1A family","CK1 protein kinase CK1 family","CAMK protein kinase DAPK family","CAMK protein kinase PI
M family","CAMK protein kinase RAD53 family","CAMK protein kinase MLCK family","AGC protein kinase DMPK family","TKL protein kinase IRAK family","Tyrosine protein kinase Axl family","TKL protein kinas
e RAF family","AGC protein kinase RSK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Abl family","STE protein kinase STE11 family","CMGC p
rotein kinase DYRK family","Tyrosine protein kinase Ret family","Aspartic protease A1A subfamily","CAMK protein kinase DCAMK1 family","CMGC protein kinase CDK family","Tyrosine protein kinase Met fami
ly","Tyrosine protein kinase Alk family","Other protein kinase ULK family","STE protein kinase STE7 family","Tyrosine protein kinase Ack family","CMGC protein kinase JNK subfamily","STE protein kinase
 SLK subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase nmo subfamily","CAMK protein kinase QIK subfamily","CMGC protein kinase ERK3","TKL protein kinase LIMK subfamily","STE protein 
kinase MSN subfamily","STE protein kinase KHS subfamily","AGC protein kinase GEK subfamily","AGC protein kinase MSK subfamily","STE protein kinase MEKK2","CMGC protein kinase p38 subfamily","CMGC prot
ein kinase HIPK subfamily","CAMK protein kinase NuaK subfamily","AGC protein kinase CRIK subfamily","CMGC protein kinase CDK7 subfamily","CAMK protein kinase BRSK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets",Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)",Tubulins,"Peptidases and proteinases","ATP-binding cassette transporter family","Receptor kinases",
"CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CK1: Casein kinase 1","AGC: C
ontaining PKA",PKG,"PKC families","AA: Aspartic (A) Peptidases","Lipid modifying kinases","ABCB subfamily","ABCG subfamily","ABCC subfamily","TK: Tyrosine kinase","Mitogen-activated protein kinases (M
AP kinases)","STE20 family","Other protein kinases","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","CAMK-like (CAMKL) family","Protein kinase D (PKD) family","Phosphoryla
se kinase (PHK) family","CAMK2 family","Casein kinase 1 (CK1) family","Death-associated kinase (DAPK) family","PIM family","Myosin Light Chain Kinase (MLCK) family","DMPK family","RSK family","STE11 f
amily","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","A1: Pepsin","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","DCAMKL family","Cyclin-de
pendent kinase (CDK) family","STE7 family","Receptor tyrosine kinases (RTKs)","JNK subfamily","Non-receptor tyrosine kinases (nRTKs)","SLK subfamily","NKF1 family","Receptor interacting protein kinase
 (RIPK) family","Numb-associated kinase (NAK) family","MKN subfamily","nmo subfamily","QIK subfamily","ERK subfamily","LIM domain kinase (LISK) family","MSN subfamily","KHS subfamily","CHK1 subfamily"
,"GEK subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","RAF family","MSK subfamily","p38 subfamily","HIPK subfamily","NuaK subfamily","Other DMPK family kinases","CDK7 subfamily","U
nc-51-like kinase (ULK) family","STE20 subfamily","BRSK subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Src family","LI
MK subfamily","Type XIII RTKs: Ephrin receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Tec family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor fam
ily","Abl family","Type XIV RTKs: RET","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Ack family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Immune System",Disease,"Vesicle-mediated transport",Metabolism,"Cellular responses to external stimuli","Neuronal System","Cell Cycle","Gene expression 
(Transcription)","Muscle contraction","Metabolism of proteins","Programmed Cell Death",Hemostasis,"Signaling by Receptor Tyrosine Kinases","Signaling by GPCR","Nervous system development","Innate Immu
ne System","Infectious disease","Membrane Trafficking","Signaling by WNT","MAPK family signaling cascades","Metabolism of lipids","Metabolism of carbohydrates","Cellular responses to stress","Transmis
sion across Chemical Synapses","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"RNA Polymerase II Transcription","Cardiac conduction","Cytokine Signaling in 
Immune system","Amyloid fiber formation","Signaling by Rho GTPases","Intracellular signaling by second messengers",Apoptosis,"Signaling by Hedgehog","Abacavir transport and metabolism","Platelet activ
ation","signaling and aggregation","Signaling by Insulin receptor","GPCR downstream signalling","Axon guidance","Toll-like Receptor Cascades","HIV Infection","Neutrophil degranulation","trans-Golgi Ne
twork Vesicle Budding","Signaling by FGFR","Beta-catenin independent WNT signaling","MAPK6/MAPK4 signaling","Sphingolipid metabolism","Glycogen metabolism","Cellular Senescence","Neurotransmitter rece
ptors and postsynaptic signal transmission","Signaling by KIT in disease","Mitotic G2-G2/M phases","FLT3 signaling in disease","Generic Transcription Pathway","Leishmania infection","Signaling by NTRK
s","Ion homeostasis","Signaling by VEGF","Fc epsilon receptor (FCERI) signaling","Signaling by Interleukins","RHO GTPase Effectors","Metabolism of steroids","PIP3 activates AKT signaling","Caspase act
ivation via extrinsic apoptotic signalling pathway","Mitotic G1 phase and G1/S transition","Hedgehog 'on' state","Abacavir transmembrane transport","Response to elevated platelet cytosolic Ca2+","Insu
lin receptor signalling cascade","G alpha (q) signalling events","Semaphorin interactions","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","Golgi Associated Vesicle Biogenesis
","Signaling by FGFR4","Ca2+ pathway","Sphingolipid de novo biosynthesis","Glycogen breakdown (glycogenolysis)","Oxidative Stress Induced Senescence","Activation of NMDA receptors and postsynaptic eve
nts","Drug resistance of KIT mutants","EPH-Ephrin signaling","G2/M Transition","Signaling by FLT3 ITD and TKD mutants","Transcriptional Regulation by TP53","Leishmania parasite growth and survival","S
ignaling by NTRK1 (TRKA)","Toll Like Receptor 2 (TLR2) Cascade","VEGFA-VEGFR2 Pathway","Transcriptional regulation by RUNX1","L1CAM interactions","FCERI mediated Ca+2 mobilization","Parasite infection
","Interleukin-1 family signaling","Signaling by ROBO receptors","RET signaling","RHO GTPases activate CIT","HIV Life Cycle","VEGF ligand-receptor interactions","Bile acid and bile salt metabolism","P
TEN Regulation","Caspase activation via Dependence Receptors in the absence of ligand","Negative regulation of the PI3K/AKT network","G1 Phase","Platelet degranulation","IRS-mediated signalling","Gast
rin-CREB signalling pathway via PKC and MAPK","Sema4D in semaphorin signaling","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Negative re
gulation of FGFR4 signaling","Post NMDA receptor activation events","Dasatinib-resistant KIT mutants","EPHB-mediated forward signaling","Centrosome maturation","STAT5 activation downstream of FLT3 ITD
 mutants","Regulation of TP53 Activity","Anti-inflammatory response favouring Leishmania parasite infection","Signalling to ERKs","Toll Like Receptor TLR6:TLR2 Cascade","RUNX1 regulates transcription 
of genes involved in BCR signaling","Recycling pathway of L1","EPHA-mediated growth cone collapse","VEGFR2 mediated cell proliferation","Leishmania phagocytosis","Interleukin-1 signaling","Role of ABL
 in ROBO-SLIT signaling","Late Phase of HIV Life Cycle","VEGF binds to VEGFR leading to receptor dimerization","Synthesis of bile acids and bile salts","Regulation of PTEN stability and activity","Sig
nalling to ERK5",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Cyclin D associated events in G1","PI3K Cascade","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone col
lapse","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Spry regulation of FGF signaling","Nef and signal transduction","CREB1 
phosphorylation through NMDA receptor-mediated activation of RAS signaling","Loss of proteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Expression and D
egradation","FCGR3A-mediated IL10 synthesis","Signalling to RAS","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Prolonged ERK activation events","Long-term potentiation","FCGR3A-mediated pha
gocytosis","Regulation of TP53 Activity through Acetylation","Transcription of the HIV genome","Sema4D mediated inhibition of cell attachment and migration","Synthesis of bile acids and bile salts via
 7alpha-hydroxycholesterol","Activation of AMPK downstream of NMDARs","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","activated TAK1 mediates p38 MAPK activa
tion","Ras activation upon Ca2+ influx through NMDA receptor","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","p38MAPK events","ARMS-mediated activation","PI5P Regulates TP53 A
cetylation","HIV Transcription Elongation","Activation of the AP-1 family of transcription factors","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing 
HIV-1 Tat"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{15215-EP2298768A1,15215EP2298768A1,Gefitinib,184475-35-2,184475352,Iressa,ZD1839,Irressat,"gefitinib (zd1839)","ZD 1839",ZD-1839,UNII-S65743JHBS,UNIIS65743JHBS,4-(3'-Chloro-4'-fluoroanilino)-7-methox
y-6-(3-morpholinopropoxy)quinazoline,4(3'Chloro4'fluoroanilino)7methoxy6(3morpholinopropoxy)quinazoline,MFCD04307832,CHEMBL939,S65743JHBS,CHEBI:49668,NC,T1181,715055,S1025,3000,Prestw-1270,"NSC 715055
",gefitinib,Gefitinib(Iressa),"Gefitinib (ZD1839)",GEFITINIB}

> <pdid>
PD003385

> <targets>
{EGFR(HER),EGFR}

> <classes>
{"Tyrosine kinase inhibitor","Protein Tyrosine Kinase"}

> <pubchem_cids>
{123631}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 43  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.8979    3.7504    0.0000 C   0  0
   -5.1969    4.5004    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0897    3.7657    0.0000 O   0  0
  -10.3910    3.0180    0.0000 C   0  0
  -11.6897    3.7702    0.0000 C   0  0
  -12.9914    3.0247    0.0000 C   0  0
  -14.2878    3.7792    0.0000 C   0  0
  -14.2827    5.2792    0.0000 C   0  0
  -12.9811    6.0247    0.0000 C   0  0
  -11.6846    5.2703    0.0000 N   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Cl  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6016   -2.9971    0.0000 O   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 C   0  0
   -3.9117   -8.2482    0.0000 N   0  0
   -3.9148   -9.7482    0.0000 C   0  0
   -5.2094   -7.4959    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  3  0
  9 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 17 26  1  0
 26 27  1  0
 26 28  2  0
 28 14  1  0
 12 29  2  0
 29  6  1  0
 29 30  1  0
 30 31  2  0
 31  4  1  0
 31 32  1  0
 32 33  1  0
 33 34  2  0
 33 35  1  0
 35 36  2  0
 36 37  1  0
 37 38  1  0
 38 39  1  0
 38 40  1  0
M  END
> <name>
UTKinase_V5

> <id>
28408

> <plate>
Kinase v5-2

> <well>
A09

> <supplier_cmpd_name>
Neratinib

> <ctcr_id>
7187

> <supplier_cmpd_id>
S2150

> <smiles>
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

> <pd_targets>
{PTK2,DSTYK,MERTK,INSR,EIF2AK4,MINK1,ERBB2,HIPK4,EGFR,KDR,FER,ERBB3,FES,FLT3,MELK,RPS6KA2,TNK2,MAP3K11,GAK,STK10,CDK16,STK35,MAP4K3,MAP4K4,STK3,MAP3K10,MAP4K2,STK17A,CSNK1G3,MAP3K3,SYK,CSNK1G2,MAPK8,W
EE1,STK24,MAP4K5,MAP2K7,MAP3K20,SIK2,STK32B,CAMK1D,MAP2K5,PTK2B,MET,BLK,SIK1,INSRR,TNIK,TAOK3,MAP2K2,ERBB4,MAP3K4,MAP3K9,MAP3K19,PRKD3,STK4,PRKD2,STK33,ABL1,FGR,SRC,MAP2K1,MAP3K13,STK17B,EPHB6,CHEK2,P
AK2,LCK,YES1,LYN,PAK1,MAPK10,TXK,CSK,MAP4K1,CSNK1E,NEK3,CHEK1,CDK7,MAP3K2,SLK,BTK,MAP3K12,STK25,STK36,CSF1R,TIE1,HCK,TEK,FYN,AXL,WEE2,NUAK1,MAST1,MST1R,JAK3,NEK2,PRKD1,PAK6,RPS6KA1,STK26,IRAK1,NUAK2,A
BCC4,ABCB11}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Transporter,Kinase,"Primary active transporter","Protein Kinase","ATP-binding cassette","TK protein kinase group","Other protein kinase group","STE protein kinase group"
,"CMGC protein kinase group","CAMK protein kinase group","AGC protein kinase group","TKL protein kinase group","CK1 protein kinase group","ABCC subfamily","ABCB subfamily","Tyrosine protein kinase Fak
 family","Tyrosine protein kinase Axl family","Tyrosine protein kinase InsR family","Other protein kinase PEK family","STE protein kinase STE20 family","Tyrosine protein kinase EGFR family","CMGC prot
ein kinase DYRK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Fer family","Tyrosine protein kinase PDGFR family","CAMK protein kinase CAMK1 family","AGC protein kinase RSK fa
mily","Tyrosine protein kinase Ack family","TKL protein kinase MLK family","Other protein kinase NAK family","CMGC protein kinase CDK family","Other protein kinase NKF4 family","CAMK protein kinase DA
PK family","CK1 protein kinase CK1 family","STE protein kinase STE11 family","Tyrosine protein kinase Syk family","CMGC protein kinase MAPK family","Other protein kinase WEE family","STE protein kinas
e STE7 family","AGC protein kinase YANK family","Tyrosine protein kinase Met family","Tyrosine protein kinase Src family","CAMK protein kinase PKD family","CAMK protein kinase unique family","Tyrosine
 protein kinase Abl family","CAMK protein kinase RAD53 family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Csk family","Other protein kinase NEK family","Other protein kinase ULK fam
ily","Tyrosine protein kinase Tie family","AGC protein kinase MAST family","Tyrosine protein kinase JakA family","TKL protein kinase IRAK family","Other protein kinase GCN2 subfamily","STE protein kin
ase MSN subfamily","CMGC protein kinase HIPK subfamily","CAMK protein kinase MELK subfamily","AGC protein kinase RSK subfamily","TKL protein kinase MLK subfamily","STE protein kinase SLK subfamily","C
MGC protein kinase TAIRE subfamily","STE protein kinase KHS subfamily","STE protein kinase MST subfamily","CK1 protein kinase CK1-g","STE protein kinase MEKK2","CMGC protein kinase JNK subfamily","STE
 protein kinase YSK subfamily","CAMK protein kinase QIK subfamily","STE protein kinase TAO subfamily","TKL protein kinase LZK subfamily","STE protein kinase PAKA subfamily","Other protein kinase Nek1"
,"CAMK protein kinase CHK1 subfamily","CMGC protein kinase CDK7 subfamily","Tyrosine protein kinase SrcA","Other protein kinase WEE1","CAMK protein kinase NuaK subfamily","STE protein kinase PAKB subf
amily"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)","ATP-binding cassette transporter family","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 ki
nases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase 1","ABCC subfamily","ABCB subfa
mily","TK: Tyrosine kinase","Other protein kinases","STE20 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CAMK-like (CAMKL) family","RSK family","TKL: Tyrosine
 kinase-like","Cyclin-dependent kinase (CDK) family","Death-associated kinase (DAPK) family","Casein kinase 1 (CK1) family","STE11 family","Mitogen-activated protein kinases (MAP kinases)","STE7 famil
y","YANK family","CAMK1 family","Protein kinase D (PKD) family","CAMK-unique family","MAST family","Non-receptor tyrosine kinases (nRTKs)","Other-unique family","Receptor tyrosine kinases (RTKs)","PEK
 family","MSN subfamily","HIPK subfamily","MELK subfamily","RSK subfamily","Mixed Lineage Kinase (MLK) family","Numb-associated kinase (NAK) family","SLK subfamily","TAIRE subfamily","NKF4 family","KH
S subfamily","MST subfamily","JNK subfamily","WEE family","YSK subfamily","QIK subfamily","TAO subfamily","STE20 subfamily","CHK1 subfamily","PAKA subfamily","NIMA (never in mitosis gene a)- related k
inase (NEK) family","CDK7 subfamily","Unc-51-like kinase (ULK) family","NuaK subfamily","PAKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","Fak family","Type XI RTKs: TAM (TYRO3
-","AXL- and MER-TK) receptor family","Type II RTKs: Insulin receptor family","GCN2 subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial g
rowth factor) receptor family","Fer family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Ack family","MLK subfamily","Syk family","Type X RTKs: HGF (hepatocyte growth factor) receptor famil
y","Src family","Abl family","LZK subfamily","Type XIII RTKs: Ephrin receptor family","Tec family","Csk family","Type XII RTKs: TIE family of angiopoietin receptors","Janus kinase (JakA) family"}

> <pathway_reactome>
{Disease,Hemostasis,"Signal Transduction","Cellular responses to external stimuli","Developmental Biology","Immune System","Vesicle-mediated transport",Metabolism,"Cell Cycle","Programmed Cell Death",
"Gene expression (Transcription)","Circadian Clock","DNA Repair","Neuronal System","Infectious disease","Cell surface interactions at the vascular wall","Intracellular signaling by second messengers",
"Cellular responses to stress","Nervous system development","Signaling by GPCR","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Diseases of signal transduction by growth factor recept
ors and second messengers","Membrane Trafficking","Signaling by Hippo","Cytokine Signaling in Immune system","Metabolism of lipids","Cell Cycle Checkpoints",Apoptosis,"RNA Polymerase II Transcription"
,Mitotic,"DNA Double-Strand Break Repair","MAPK family signaling cascades","Transmission across Chemical Synapses","Platelet activation","signaling and aggregation","Leishmania infection","PIP3 activa
tes AKT signaling","Response of EIF2AK4 (GCN2) to amino acid deficiency","Cellular Senescence","Axon guidance","GPCR downstream signalling","Signaling by VEGF","Signaling by SCF-KIT","Signaling by Ins
ulin receptor","Toll-like Receptor Cascades","Oncogenic MAPK signaling","trans-Golgi Network Vesicle Budding","Neutrophil degranulation","Signaling by Interleukins","Sphingolipid metabolism","G2/M Che
ckpoints","Apoptotic execution phase","Signaling by NTRKs","Generic Transcription Pathway","HIV Infection","Fc epsilon receptor (FCERI) signaling","Mitotic G2-G2/M phases","Homology Directed Repair","
MAPK1/MAPK3 signaling","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by MST1","Regulation of mitotic cell cycle","Response to elevated platelet cytosolic Ca2+","Metaboli
sm of steroids","Parasite infection","Negative regulation of the PI3K/AKT network","Oxidative Stress Induced Senescence","Semaphorin interactions","G alpha (q) signalling events","VEGFA-VEGFR2 Pathway
","Insulin receptor signalling cascade","Toll Like Receptor 5 (TLR5) Cascade","Signaling by RAS mutants","Golgi Associated Vesicle Biogenesis","Interleukin-1 family signaling","Leishmania parasite gro
wth and survival","Sphingolipid de novo biosynthesis","G2/M DNA damage checkpoint","Apoptotic cleavage of cellular proteins","Signaling by NTRK1 (TRKA)","Interleukin-2 family signaling","Transcription
al regulation by RUNX1","EPH-Ephrin signaling","Transcriptional Regulation by TP53","Host Interactions of HIV factors","FCERI mediated Ca+2 mobilization","G2/M Transition","HDR through Homologous Reco
mbination (HRR) or Single Strand Annealing (SSA)","HIV Life Cycle","Transcriptional Regulation by VENTX","RAF/MAP kinase cascade","Activation of NMDA receptors and postsynaptic events","APC/C-mediated
 degradation of cell cycle proteins","Signaling by ROBO receptors","Platelet degranulation","Bile acid and bile salt metabolism","Leishmania phagocytosis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signali
ng","Sema4D in semaphorin signaling","Gastrin-CREB signalling pathway via PKC and MAPK","VEGFR2 mediated cell proliferation","CRMPs in Sema3A signaling","IRS-mediated signalling","MyD88 cascade initia
ted on plasma membrane","Signaling downstream of RAS mutants","Interleukin-1 signaling","Anti-inflammatory response favouring Leishmania parasite infection","Chk1/Chk2(Cds1) mediated inactivation of C
yclin B:Cdk1 complex","Signalling to ERK5","Interleukin-2 signaling","RUNX1 regulates transcription of genes involved in BCR signaling","Signalling to ERKs","EPHB-mediated forward signaling","Regulati
on of TP53 Activity","The role of Nef in HIV-1 replication and disease pathogenesis","Centrosome maturation","HDR through Homologous Recombination (HRR)","Late Phase of HIV Life Cycle","Post NMDA rece
ptor activation events","Interleukin-15 signaling","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Activation of RAC1","Synthesis of bile acids and bile salts","FCGR3A-
mediated phagocytosis","Sema4D induced cell migration and growth-cone collapse","EGFR Transactivation by Gastrin","PI3K Cascade","MAP kinase activation","FCGR3A-mediated IL10 synthesis","Sema4D mediat
ed inhibition of cell attachment and migration","Prolonged ERK activation events","Signalling to RAS","Regulation of TP53 Expression and Degradation","Nef and signal transduction","Nef-mediates down m
odulation of cell surface receptors by recruiting them to clathrin adapters","Loss of proteins required for interphase microtubule organization from the centrosome","Homologous DNA Pairing and Strand 
Exchange","Transcription of the HIV genome","Long-term potentiation","Regulation of TP53 Activity through Phosphorylation","APC/C:Cdc20 mediated degradation of mitotic proteins","Synthesis of bile aci
ds and bile salts via 7alpha-hydroxycholesterol","MAPK targets/ Nuclear events mediated by MAP kinases","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","Frs2-med
iated activation","p38MAPK events","Regulation of TP53 Degradation","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes","Presynaptic phase of homologous DNA pairing and strand ex
change","HIV Transcription Elongation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","activated TAK1 mediates p38 MAPK activation","CREB pho
sphorylation","Activation of the AP-1 family of transcription factors","Tat-mediated elongation of the HIV-1 transcript","APC-Cdc20 mediated degradation of Nek2A","Formation of HIV-1 elongation comple
x containing HIV-1 Tat"}

> <broad_targets>
{EGFR,ERBB2,KDR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{"ERATINIB (HKI272",Q-101402,Q101402,Q6995920,Neratinib,698387-09-6,698387096,HKI-272,HKI272,"Neratinib (HKI-272)","Neratinib (HKI272)",Nerlynx,"HKI 272",Neratinib(HKI-272),Neratinib(HKI272),UNII-JJH9
4R3PWB,UNIIJJH94R3PWB,PB-272,PB272,JJH94R3PWB,CHEMBL180022,"698387-09-6 (free base)","698387096 (free base)",WAY-179272,WAY179272,C30H29ClN6O3,"Neratinib (USAN:INN)",18404,S2150,neratinib}

> <pdid>
PD003298

> <targets>
{EGFR(HER),HER2,EGFR}

> <classes>
{}

> <pubchem_cids>
{9915743}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 24  0  0  0  0            999 V2000
    8.8990    0.7552    0.0000 H   0  3
    6.3990    0.7552    0.0000 Cl  0  5
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Br  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 19 13  1  0
 11 20  2  0
 20  7  1  0
 20 21  1  0
 21 22  2  0
 22  5  1  0
 22 23  1  0
 23 24  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28409

> <plate>
Kinase v5-2

> <well>
A11

> <supplier_cmpd_name>
PD153035 hydrochloride

> <ctcr_id>
1013

> <supplier_cmpd_id>
S1079

> <smiles>
[H+].[Cl-].COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC

> <pd_targets>
{ABL1,ABL2,MAPT,EGFR,MAPK1,KDM4E,ALOX15,LEF,BLM,HPGD,NFKB1,HSD17B10,PMP22,CYP3A4,GMNN,FBP1,PKMYT1,LMNA,RAF1,HIF1A,CYP2D6,CYP1A2,MAPK14,CHRM1,FFP,GLA,TP53,KMT2A,MEN1,ALDH1A1,MKNK1,SRC,LCK,KDR,EPHB2,TSH
R,ERBB2,CYP2C19,MAPK11,MAPK12,MAPK13,ALD,RORC,CDK1,ABL,ERBB4,CYP2C9,PDGFRB,ABCG2,GAK}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator","Unclassified protein","Other nuclear protein","Transcription factor","Membrane receptor",Kinase,Eraser,Oxidoreductase,Protease,"Cytochrome P45
0","Family A G protein-coupled receptor",Transferase,Hydrolase,Reader,"Protein Kinase","Lysine demethylase","Metallo protease","Cytochrome P450 family 3","Cytochrome P450 family 2","Cytochrome P450 fa
mily 1","Small molecule receptor (family A GPCR)",Bromodomain,"TK protein kinase group","CMGC protein kinase group","Jumonji domain-containing","Metallo protease MAE clan","Cytochrome P450 family 3A",
"Other protein kinase group","TKL protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Monoamine receptor","CAMK protein kinase group","Tyrosine protein kinase Abl family","T
yrosine protein kinase EGFR family","CMGC protein kinase MAPK family","Metallo protease M34 family","Cytochrome P450 3A4","Other protein kinase WEE family","TKL protein kinase RAF family","Cytochrome 
P450 2D6","Cytochrome P450 1A1","Acetylcholine receptor","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Src family","CMGC protein kinase ERK1","CMGC protein kinase p38 subfamily","CAMK 
protein kinase MNK subfamily",Transporter,"Nuclear receptor","Primary active transporter","Peptide receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","ATP-binding cassette","Glycohormone
 receptor","Cytochrome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","ABCG subfamily","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Eph family","Cytochrome P450 2C19
","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase CDK family","Cytochrome P450 2C9","Tyrosine protein kinase PDGFR family","Other protein kinase NAK family","CMGC protein 
kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","G protein-coupled receptors","Receptor kinases","CMGC: Containing
 CDK",MAPK,GSK3,"CLK families","1.14.11.- Histone demethylases",Lipoxygenases,"Prostaglandin synthases","CYP3 family","CYP2 family: drug metabolising subset","CYP1 family","Acetylcholine receptors (mu
scarinic)","CAMK: Calcium/calmodulin-dependent protein kinases","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Other protein kinases","TKL: Tyrosine kinase-like","MAPK-Activa
ted Protein Kinase (MAPKAPK) family","Receptor tyrosine kinases (RTKs)","ERK subfamily","WEE family","RAF family","p38 subfamily","MKN subfamily","Non-receptor tyrosine kinases (nRTKs)","Type I RTKs: 
ErbB (epidermal growth factor) receptor family","Src family",Transporters,"Nuclear hormone receptors","ATP-binding cassette transporter family","Glycoprotein hormone receptors","1F. Retinoic acid-rela
ted orphans","ABCG subfamily","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","Numb-associated kinase (NAK) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","T
ype XIII RTKs: Ephrin receptor family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Neuronal System","Signal Transduction","Immune System",Metabolism,Disease,"DNA Repair","Developmental Biology","Cell Cycle","Cellular responses to external stimuli","Transmission across Chemical Syn
apses","Signaling by GPCR","Innate Immune System","Metabolism of lipids","Infectious disease","DNA Double-Strand Break Repair","Cytokine Signaling in Immune system","Metabolism of amino acids and deri
vatives","Nervous system development",Mitotic,"Metabolism of carbohydrates","MAPK family signaling cascades","Cellular responses to stress","Biological oxidations","Cell Cycle Checkpoints","Signaling 
by Receptor Tyrosine Kinases","Neurotransmitter receptors and postsynaptic signal transmission","GPCR downstream signalling","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving med
iators (SPMs)","Uptake and actions of bacterial toxins","Homology Directed Repair","Signaling by Interleukins","Branched-chain amino acid catabolism","EGR2 and SOX10-mediated initiation of Schwann cel
l myelination","Mitotic G1 phase and G1/S transition","Glucose metabolism","Mitotic G2-G2/M phases","M Phase","MAPK1/MAPK3 signaling","Cellular response to hypoxia","Phase I - Functionalization of com
pounds","GPCR ligand binding","Sphingolipid metabolism","G1/S DNA Damage Checkpoints","Signaling by FGFR","Signaling by NTRKs","HIV Infection","Activation of NMDA receptors and postsynaptic events","G
 alpha (q) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Biosynthesis of DPA-derived SPMs","Uptake and function of anthrax toxins","HDR through Homologous Recombination (HRR) or Single Str
and Annealing (SSA)","Biosynthesis of DHA-derived SPMs","Interleukin-1 family signaling","G1/S Transition",Gluconeogenesis,"G2/M Transition","Mitotic Metaphase and Anaphase","RAF/MAP kinase cascade","
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Cytochrome P450 - arranged by substrate type","Class A/1 (Rhodopsin-like receptors)","Glycosphingolipid metabolism","p53-Depe
ndent G1/S DNA damage checkpoint","Ethanol oxidation","Signaling by FGFR4","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Post NMDA receptor activation events","Gastrin-CREB signallin
g pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Biosynthesis of DPAn-3 SPMs","HDR through Homologous Recombination (HRR)","Biosynthesis of D-series resolvins","Interleukin-1 
signaling","Biosynthesis of maresins","Activation of the pre-replicative complex","Cyclin A/B1/B2 associated events during G2/M transition","Mitotic Anaphase","Negative regulation of MAPK pathway",Xen
obiotics,"Amine ligand-binding receptors","p53-Dependent G1 DNA Damage Response","Negative regulation of FGFR4 signaling","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathoge
nesis","Activation of AMPK downstream of NMDARs","EGFR Transactivation by Gastrin","MAP kinase activation","Biosynthesis of DPAn-3-derived protectins and resolvins","Homologous DNA Pairing and Strand 
Exchange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of maresin-like SPMs","Nuclear Envelope (NE) Reassembly","Negative feedback regulation of MAPK pathway","CYP2E1 reactions","Aromati
c amines can be N-hydroxylated or N-dealkylated by CYP1A2","Muscarinic acetylcholine receptors","Stabilization of p53","Spry regulation of FGF signaling","Signalling to RAS","Nef-mediates down modulat
ion of cell surface receptors by recruiting them to clathrin adapters","MAPK targets/ Nuclear events mediated by MAP kinases","Presynaptic phase of homologous DNA pairing and strand exchange","Initiat
ion of Nuclear Envelope (NE) Reformation","Autodegradation of the E3 ubiquitin ligase COP1","p38MAPK events","Nef Mediated CD4 Down-regulation","ERK/MAPK targets","Activation of the AP-1 family of tra
nscription factors","ERKs are inactivated","Gene expression (Transcription)","Vesicle-mediated transport","RNA Polymerase II Transcription","Intracellular signaling by second messengers","Abacavir tra
nsport and metabolism","Membrane Trafficking","Signaling by VEGF","Axon guidance","Leishmania infection","Generic Transcription Pathway","Regulation of mitotic cell cycle","PIP3 activates AKT signalin
g","Abacavir transmembrane transport","trans-Golgi Network Vesicle Budding","VEGFA-VEGFR2 Pathway","EPH-Ephrin signaling","Leishmania parasite growth and survival","Semaphorin interactions","Transcrip
tional regulation by RUNX3","APC/C-mediated degradation of cell cycle proteins","Parasite infection","Negative regulation of the PI3K/AKT network","Golgi Associated Vesicle Biogenesis","VEGFR2 mediate
d cell proliferation","EPHB-mediated forward signaling","Anti-inflammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","RUNX3 Regulates Immune Response and Cell 
Migration","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Leishmania phagocytosis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","ADORA2B mediated anti-inflammatory
 cytokines production","Sema4D induced cell migration and growth-cone collapse","APC/C:Cdc20 mediated degradation of mitotic proteins","Long-term potentiation","FCGR3A-mediated phagocytosis","APC:Cdc2
0 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{EGFR,MAPK14}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{PD153035HCl,183322-45-4,183322454,"PD153035 hydrochloride","N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride","N(3Bromophenyl)6,7dimethoxyquinazolin4amine hydrochloride","PD-153035 hyd
rochloride","PD153035 HCl","PD 153035 HYDROCHLORIDE","PD153035 (Hydrochloride)","AG 1517 hydrochlorid",S1079,"PD 153035"}

> <pdid>
PD002607

> <targets>
{EGFR,PTK,EGFR(HER)}

> <classes>
{}

> <pubchem_cids>
{11246488}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 35  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.8979    3.7504    0.0000 C   0  0
   -5.1969    4.5004    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0875    3.7680    0.0000 F   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Cl  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6016   -2.9971    0.0000 O   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 C   0  0
   -3.9117   -8.2482    0.0000 N   0  0
   -3.9148   -9.7482    0.0000 C   0  0
   -5.2094   -7.4959    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  3  0
  9 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 19 21  2  0
 21 14  1  0
 12 22  2  0
 22  6  1  0
 22 23  1  0
 23 24  2  0
 24  4  1  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  2  3
 29 30  1  0
 30 31  1  0
 31 32  1  0
 31 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28410

> <plate>
Kinase v5-2

> <well>
A13

> <supplier_cmpd_name>
Pelitinib

> <ctcr_id>
2699

> <supplier_cmpd_id>
S1392

> <smiles>
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCN(C)C

> <pd_targets>
{MERTK,AXL,TIE1,ABL1,MYLK2,ERBB2,EGFR,FGR,ABL2,CSK,GAK,SRC,STK36,PHKG2,AAK1,HCK,STK17A,PKMYT1,BTK,KDR,PIP4K2B,CSNK1A1L,ALK,MARK1,MET,STK4,STK3,SLK,CIT,LCK,CSNK1E,CLK2,EIF2AK2,SYK,YES1,STK25,DYRK1B,NUA
K2,NEK2,STK24,WEE1,TEK,BMX,ERBB4,MAP3K4,COQ8B,TXK,NEK1,TNK2,CLK3,CLK1,EPHA5,CLK4,EPHA3,PHKG1,TNIK,PTK2,FER,FYN,EPHB1,EPHA6,FRK,PRKCD,EPHB4,STK38L,FLT3,STK10,MAP2K1,JAK3,SIK2,MAP4K3,BLK,STK32B,MAP3K20,
CAMKK2,CAMKK1,EPHA8,MAP4K4,TNNI3K,DMPK,DCLK3,MAP2K2,CAMK1D,TYRO3,WEE2,CDK16,PAK1,STK17B,MAP4K5,DAPK3,JAK2,TUBA1A,ITK,STK33,CSF1R,CSNK1D,FES,BMP2K,LYN,CHEK1,RPS6KA2,EIF2AK4,MAP4K1,ULK3,MAP3K12}

> <pathway_gtopdb>
{Enzyme,"Structural protein",Kinase,"Protein Kinase","TK protein kinase group","CAMK protein kinase group","Other protein kinase group","CK1 protein kinase group","TKL protein kinase group","STE prote
in kinase group","AGC protein kinase group","CMGC protein kinase group","Atypical protein kinase group","Tyrosine protein kinase Axl family","Tyrosine protein kinase Tie family","Tyrosine protein kina
se Abl family","CAMK protein kinase MLCK family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Csk family","Other protein kinase NAK family","Othe
r protein kinase ULK family","CAMK protein kinase PHk family","CAMK protein kinase DAPK family","Other protein kinase WEE family","Tyrosine protein kinase Tec family","Tyrosine protein kinase VEGFR fa
mily","CK1 protein kinase CK1 family","TKL protein kinase STKR family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Met family","STE protein kinase STE20 family","AGC protein kinase DMP
K family","CMGC protein kinase CLK family","Other protein kinase PEK family","Tyrosine protein kinase Syk family","CMGC protein kinase DYRK family","Other protein kinase NEK family","STE protein kinas
e STE11 family","Atypical protein kinase ABC1 family","Tyrosine protein kinase Ack family","Tyrosine protein kinase Eph family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Fer family
","AGC protein kinase PKC family","AGC protein kinase NDR family","Tyrosine protein kinase PDGFR family","STE protein kinase STE7 family","Tyrosine protein kinase JakA family","AGC protein kinase YANK
 family","TKL protein kinase MLK family","Other protein kinase CAMKK family","CAMK protein kinase DCAMK1 family","CMGC protein kinase CDK family","CAMK protein kinase unique family","AGC protein kinas
e RSK family","CK1 protein kinase CK1-a","TKL protein kinase STKR Type 1 subfamily","CAMK protein kinase MARK subfamily","STE protein kinase MST subfamily","STE protein kinase SLK subfamily","AGC prot
ein kinase CRIK subfamily","Other protein kinase PKR","STE protein kinase YSK subfamily","CMGC protein kinase Dyrk1 subfamily","CAMK protein kinase NuaK subfamily","Atypical protein kinase ABC1-A subf
amily","STE protein kinase MSN subfamily","Tyrosine protein kinase SrcA","AGC protein kinase PKC delta subfamily","CAMK protein kinase QIK subfamily","STE protein kinase KHS subfamily","TKL protein ki
nase MLK subfamily","Other protein kinase Meta subfamily","TKL protein kinase HH498 subfamily","AGC protein kinase GEK subfamily","Other protein kinase WEE1","CMGC protein kinase TAIRE subfamily","STE
 protein kinase PAKA subfamily","CAMK protein kinase CHK1 subfamily","AGC protein kinase RSK subfamily","Other protein kinase GCN2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)",Tubulins,"Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Lipid modifying kinases","CK1:
 Casein kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"TK: Tyrosine k
inase","Myosin Light Chain Kinase (MLCK) family","Other protein kinases","Phosphorylase kinase (PHK) family","Death-associated kinase (DAPK) family","Type II PIP kinases (1-phosphatidylinositol-5-phos
phate 4-kinase family)","Casein kinase 1 (CK1) family","CAMK-like (CAMKL) family","STE20 family","DMPK family","CLK family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) famil
y","STE11 family","ABC1 family","Protein kinase C (PKC) family","NDR family","STE7 family","YANK family","TKL: Tyrosine kinase-like","DCAMKL family","CAMK1 family","Cyclin-dependent kinase (CDK) famil
y","CAMK-unique family","RSK family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Numb-associated kinase (NAK) family","Unc-51-like kinase (ULK) family","NAK family","WE
E family","MARK subfamily","MST subfamily","SLK subfamily","Other DMPK family kinases","PEK family","YSK subfamily","Dyrk1 subfamily","NuaK subfamily","NIMA (never in mitosis gene a)- related kinase (
NEK) family","ABC1-B subfamily","MSN subfamily","Delta subfamily","QIK subfamily","KHS subfamily","Mixed Lineage Kinase (MLK) family","CAMKK family","GEK subfamily","TAIRE subfamily","PAKA subfamily",
"CHK1 subfamily","RSK subfamily","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Abl family","Type I RTKs: ErbB (epidermal growth 
factor) receptor family","Src family","Csk family","Tec family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor famil
y","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Other PEK family kinases","Syk family","Ack family","Type XIII RTKs: Ephrin receptor family","Fak family","Fer family","Type III RTKs:
 PDGFR",CSFR,Kit,"FLT3 receptor family","Janus kinase (JakA) family","MLK subfamily","Meta subfamily","HH498 subfamily","GCN2 subfamily","LZK subfamily"}

> <pathway_reactome>
{Hemostasis,"Signal Transduction",Disease,"Developmental Biology","Vesicle-mediated transport",Metabolism,"Cell Cycle","Gene expression (Transcription)","Programmed Cell Death","Neuronal System","Immu
ne System","Cellular responses to external stimuli","Muscle contraction","DNA Repair","Cell surface interactions at the vascular wall","Signaling by Receptor Tyrosine Kinases","Infectious disease","Ne
rvous system development","Signaling by GPCR","Diseases of signal transduction by growth factor receptors and second messengers","Membrane Trafficking","Metabolism of carbohydrates",Mitotic,"RNA Polym
erase II Transcription","Signaling by Hippo","Signaling by Rho GTPases",Apoptosis,"Cell Cycle Checkpoints","MAPK family signaling cascades","Metabolism of lipids","Transmission across Chemical Synapse
s","Innate Immune System","Cellular responses to stress","Intracellular signaling by second messengers","Cytokine Signaling in Immune system","Cardiac conduction","Adaptive Immune System","DNA Double-
Strand Break Repair","Signaling by Hedgehog","Signaling by VEGF","Leishmania infection","Axon guidance","GPCR downstream signalling","Oncogenic MAPK signaling","trans-Golgi Network Vesicle Budding","S
ignaling by NTRKs","Glycogen metabolism","Clathrin-mediated endocytosis","HIV Infection","Mitotic G2-G2/M phases","Generic Transcription Pathway","RHO GTPase Effectors","Influenza Infection","Regulati
on of mitotic cell cycle","Apoptotic execution phase","G2/M Checkpoints","MAPK1/MAPK3 signaling","Phospholipid metabolism","Neurotransmitter receptors and postsynaptic signal transmission","Fc epsilon
 receptor (FCERI) signaling","Cellular Senescence","Signaling by SCF-KIT","PIP3 activates AKT signaling","DAG and IP3 signaling","Signaling by Insulin receptor","Neutrophil degranulation","Signaling b
y Interleukins","Ion homeostasis","Caspase activation via extrinsic apoptotic signalling pathway","Mitotic G1 phase and G1/S transition","TCR signaling","Homology Directed Repair","Toll-like Receptor 
Cascades","Response of EIF2AK4 (GCN2) to amino acid deficiency","Hedgehog 'on' state","VEGFA-VEGFR2 Pathway","Parasite infection","Semaphorin interactions","G alpha (q) signalling events","Leishmania 
parasite growth and survival","Signaling by ROBO receptors","Signaling by RAS mutants","Golgi Associated Vesicle Biogenesis","Signaling by NTRK1 (TRKA)","Glycogen breakdown (glycogenolysis)","Cargo re
cognition for clathrin-mediated endocytosis","Host Interactions of HIV factors","G2/M Transition","Transcriptional Regulation by TP53","RHO GTPases activate CIT","NS1 Mediated Effects on Host Pathways
","APC/C-mediated degradation of cell cycle proteins","Apoptotic cleavage of cellular proteins","G2/M DNA damage checkpoint","RAF/MAP kinase cascade","PI Metabolism","Activation of NMDA receptors and 
postsynaptic events","FCERI mediated Ca+2 mobilization","EPH-Ephrin signaling","Oxidative Stress Induced Senescence","PTEN Regulation","CaM pathway","Insulin receptor signalling cascade","Interleukin-
2 family signaling","Transcriptional regulation by RUNX1","Caspase activation via Dependence Receptors in the absence of ligand","G1 Phase","Generation of second messenger molecules","Transcriptional 
Regulation by VENTX","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Toll Like Receptor 5 (TLR5) Cascade","Leishmania phagocytosis","Sema4D in semaphorin signaling","Gas
trin-CREB signalling pathway via PKC and MAPK","Anti-inflammatory response favouring Leishmania parasite infection","Role of ABL in ROBO-SLIT signaling","Signaling downstream of RAS mutants","Signalli
ng to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis","Cyclin A/B1/B2 associated events during G2/M transition","VEGFR2 mediated cell proliferation","Regulation of TP53 Activity"
,"Centrosome maturation","Inhibition of PKR","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Synthesis 
of PIPs at the plasma membrane","Post NMDA receptor activation events","EPHA-mediated growth cone collapse","EPHB-mediated forward signaling","Regulation of PTEN stability and activity","Calmodulin in
duced events","IRS-mediated signalling","Interleukin-15 signaling","RUNX1 regulates transcription of genes involved in BCR signaling","Cyclin D associated events in G1","CRMPs in Sema3A signaling","HD
R through Homologous Recombination (HRR)","MyD88 cascade initiated on plasma membrane","FCGR3A-mediated phagocytosis","Sema4D induced cell migration and growth-cone collapse","EGFR Transactivation by 
Gastrin","FCGR3A-mediated IL10 synthesis","Signalling to RAS","Nef and signal transduction","Regulation of TP53 Activity through Acetylation","Sema4D mediated inhibition of cell attachment and migrati
on","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc2
0 mediated degradation of mitotic proteins","Long-term potentiation","PI3K Cascade","Prolonged ERK activation events","Activation of AMPK downstream of NMDARs","Activation of RAC1 downstream of NMDARs
","Homologous DNA Pairing and Strand Exchange","MAP kinase activation","p38MAPK events","PI5P Regulates TP53 Acetylation","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes","APC
:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Frs2-mediated activation","Presynaptic phase of homologous DNA pairing and strand exchange","MAPK
 targets/ Nuclear events mediated by MAP kinases","APC-Cdc20 mediated degradation of Nek2A","CREB phosphorylation"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{CHEMBL2135461,HMS3295K19,HMS3654P21,NCGC00263103-01,NCGC0026310301,AK170455,DB-068677,DB068677,FT-0654148,FT0654148,FT-0771104,FT0771104,Q27163271,S1392,Pelitinib,"Pelitinib (EKB-569)"}

> <pdid>
PD011006

> <targets>
{EGFR(HER),EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{216467}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2982    3.7531    0.0000 N   0  0
    1.2960    5.2539    0.0000 C   0  0
   -0.0056    5.9995    0.0000 C   0  0
   -0.0108    7.4995    0.0000 C   0  0
    1.2856    8.2540    0.0000 C   0  0
    1.2804    9.7540    0.0000 Br  0  0
    2.5873    7.5085    0.0000 C   0  0
    2.5924    6.0085    0.0000 C   0  0
    3.8941    5.2631    0.0000 F   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6060   -6.0003    0.0000 C   0  0
   -2.6060   -7.5003    0.0000 C   0  0
   -1.3070   -8.2503    0.0000 N   0  0
   -1.3071   -9.7503    0.0000 C   0  0
   -0.0080   -7.5003    0.0000 C   0  0
   -0.0079   -6.0003    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14  8  1  0
 14 15  1  0
  6 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19  5  1  0
 19 20  1  0
 20 21  2  0
 21  3  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 27 29  1  0
 29 30  1  0
 30 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28411

> <plate>
Kinase v5-2

> <well>
A15

> <supplier_cmpd_name>
Vandetanib

> <ctcr_id>
4018

> <supplier_cmpd_id>
S1046

> <smiles>
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC4CCN(C)CC4

> <pd_targets>
{FGFR1,FLT1,EGFR,KDR,TEK,PDGFRB,MAP2K1,MAP2K2,SIK2,ALK,ACVRL1,LTK,MAP4K2,FYN,CSK,DDR2,EPHA4,FGFR2,EPHA2,EPHB1,HCK,TNIK,YES1,ERBB2,CDC42BPA,CDC42BPB,RIPK2,SRC,STK32A,PLK4,COQ8A,COQ8B,ACVR1,HUNK,RIPK4,C
SNK1E,FLT3,MAP3K19,TXK,AURKC,SRMS,TESK1,RPS6KA1,KIT,CSF1R,ABL1,IRAK1,FRK,EPHB4,MKNK2,MAP4K5,EPHA6,MAP4K3,AURKB,BLK,MAP4K4,MERTK,AXL,EPHA7,FLT4,MET,LCK,BTK,ULK3,ERBB3,RET,STK10,EPHB6,DDR1,GAK,PHKG2,PHK
G1,FGFR3,MAP3K20,MAPK6,EPHA3,MAPK14,ROCK2,PTK6,LYN,EPHB2,EPHA1,TYRO3,MAP3K4,MKNK1,TNNI3K,PDGFRA,SIK3,LRRK2,ABL2,EPHA8,EPHA5,ERBB4,IRAK4,STK33,CIT,CDK7,TIE1,PRKAA1,RPS6KA6,SIK1,FGFR4,CDC42BPG,RORC,FGR,
MAP2K5,TUBA1A,MAP4K1,SLK,MINK1,MST1R,BMPR1B,HTT,STK35,RPS6KB1,KIF5B,EPHA10,EPHB3,VEGFA}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Transcription factor","Structural protein","Secreted protein",Kinase,"Nuclear receptor","Protein Kinase","Nuclear hormone receptor subfamily 1","TK protein kinase group
","STE protein kinase group","CAMK protein kinase group","TKL protein kinase group","AGC protein kinase group","Other protein kinase group","Atypical protein kinase group","CK1 protein kinase group","
CMGC protein kinase group","Nuclear hormone receptor subfamily 1 group F","Tyrosine protein kinase FGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase EGFR family","Tyrosine p
rotein kinase Tie family","Tyrosine protein kinase PDGFR family","STE protein kinase STE7 family","CAMK protein kinase CAMK1 family","TKL protein kinase STKR family","Tyrosine protein kinase Alk famil
y","STE protein kinase STE20 family","Tyrosine protein kinase Src family","Tyrosine protein kinase Csk family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Eph family","AGC protein ki
nase DMPK family","TKL protein kinase RIPK family","AGC protein kinase YANK family","Other protein kinase PLK family","Atypical protein kinase ABC1 family","CK1 protein kinase CK1 family","STE protein
 kinase STE11 family","Tyrosine protein kinase Tec family","Other protein kinase AUR family","TKL protein kinase LISK family","AGC protein kinase RSK family","Tyrosine protein kinase Abl family","TKL 
protein kinase IRAK family","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Met family","Other protein kinase ULK family","Tyrosine protein kinase Re
t family","Other protein kinase NAK family","CAMK protein kinase PHk family","TKL protein kinase MLK family","CMGC protein kinase MAPK family","TKL protein kinase LRRK family","CAMK protein kinase uni
que family","CMGC protein kinase CDK family","Nuclear hormone receptor subfamily 1 group F member 3","Other protein kinase NKF4 family","CAMK protein kinase QIK subfamily","TKL protein kinase STKR Typ
e 1 subfamily","STE protein kinase KHS subfamily","Tyrosine protein kinase SrcA","STE protein kinase MSN subfamily","AGC protein kinase GEK subfamily","Atypical protein kinase ABC1-A subfamily","TKL p
rotein kinase STKR1","Tyrosine protein kinase Srm","TKL protein kinase TESK subfamily","AGC protein kinase RSK subfamily","CAMK protein kinase MNK subfamily","STE protein kinase SLK subfamily","TKL pr
otein kinase MLK subfamily","CMGC protein kinase ERK3","CMGC protein kinase p38 subfamily","AGC protein kinase ROCK subfamily","TKL protein kinase HH498 subfamily","AGC protein kinase CRIK subfamily",
"CMGC protein kinase CDK7 subfamily","CAMK protein kinase AMPK subfamily","AGC protein kinase p70 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Nuclear hormone receptors",Tubulins,"Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile
 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC families",Atypical,"CK1: Casein kinase 1","CMGC: Containing CDK",MAPK,GSK3,"CLK families","1F. Retinoic
 acid-related orphans","TK: Tyrosine kinase","STE7 family","CAMK-like (CAMKL) family","TKL: Tyrosine kinase-like","STE20 family","DMPK family","YANK family","Other protein kinases","ABC1 family","Case
in kinase 1 (CK1) family","RSK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Phosphorylase kinase (PHK) family","Mitogen-activated protein kinases (MAP kinases)","STE11 family","CAMK-uniqu
e family","Cyclin-dependent kinase (CDK) family","Receptor tyrosine kinases (RTKs)","QIK subfamily","Receptor serine/threonine kinase (RSTK) family","KHS subfamily","Non-receptor tyrosine kinases (nRT
Ks)","MSN subfamily","GEK subfamily","Receptor interacting protein kinase (RIPK) family","Polo-like kinase (PLK) family","ABC1-B subfamily","HUNK subfamily","STE20 subfamily","Aurora kinase (Aur) fami
ly","LIM domain kinase (LISK) family","RSK subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","MKN subfamily","Unc-51-like kinase (ULK) family","SLK subfamily","Numb-associated kinase
 (NAK) family","Mixed Lineage Kinase (MLK) family","ERK subfamily","p38 subfamily","Rho kinase","Leucine-rich repeat kinase (LRRK) family","Other DMPK family kinases","CDK7 subfamily","AMPK subfamily"
,"NKF4 family","p70 subfamily","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type I RTKs: ErbB (epidermal gro
wth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor famil
y","Type I receptor serine/threonine kinases","Src family","Csk family","Type XVI RTKs: DDR (collagen receptor) family","Type XIII RTKs: Ephrin receptor family","Tec family","TESK subfamily","Abl fami
ly","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIV RTKs: RET","MLK subfamily","HH498 subfamily"}

> <pathway_reactome>
{Disease,"Signal Transduction","Extracellular matrix organization","Developmental Biology","Cellular responses to external stimuli","Immune System","Cell Cycle","Cell-Cell communication","Gene express
ion (Transcription)",Hemostasis,"Vesicle-mediated transport",Metabolism,"Neuronal System","Circadian Clock","Diseases of signal transduction by growth factor receptors and second messengers","Signalin
g by Receptor Tyrosine Kinases","Signaling by GPCR","MAPK family signaling cascades","Intracellular signaling by second messengers","Signaling by TGFB family members","Infectious disease","Non-integri
n membrane-ECM interactions","Nervous system development","Cellular responses to stress","Innate Immune System",Mitotic,"Signaling by Non-Receptor Tyrosine Kinases","Cell junction organization","RNA P
olymerase II Transcription","Cell surface interactions at the vascular wall","Signaling by Hedgehog","Membrane Trafficking","Metabolism of carbohydrates","Transmission across Chemical Synapses","Signa
ling by Rho GTPases","MTOR signalling","Signaling by FGFR in disease","Signaling by VEGF","GPCR downstream signalling","MAPK1/MAPK3 signaling","PIP3 activates AKT signaling","Signaling by NTRKs","Sign
aling by BMP","HIV Infection","Oncogenic MAPK signaling","Axon guidance","Cellular Senescence","Leishmania infection","Toll-like Receptor Cascades","Mitotic G2-G2/M phases","Signaling by Insulin recep
tor","Fc epsilon receptor (FCERI) signaling","Signaling by PTK6","Cell-extracellular matrix interactions","Signaling by KIT in disease","Generic Transcription Pathway","M Phase","Hedgehog 'on' state",
"Neutrophil degranulation","trans-Golgi Network Vesicle Budding","Glycogen metabolism","MAPK6/MAPK4 signaling","Mitotic G1 phase and G1/S transition","Signaling by FGFR","Signaling by PDGFR in disease
","Neurotransmitter receptors and postsynaptic signal transmission","RHO GTPase Effectors","Signaling by MST1","mTORC1-mediated signalling","Signaling by FGFR1 in disease","VEGF ligand-receptor intera
ctions","G alpha (q) signalling events","VEGFA-VEGFR2 Pathway","RAF/MAP kinase cascade","Negative regulation of the PI3K/AKT network","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Si
gnaling by RAS mutants","EPH-Ephrin signaling","Signaling by FGFR2 in disease","Oxidative Stress Induced Senescence","Leishmania parasite growth and survival","Semaphorin interactions","Toll Like Rece
ptor 5 (TLR5) Cascade","G2/M Transition","Insulin receptor signalling cascade","FCERI mediated Ca+2 mobilization","PTK6 Down-Regulation","Regulation of cytoskeletal remodeling and cell spreading by IP
P complex components","Drug resistance of KIT mutants","Transcriptional Regulation by VENTX","Parasite infection","PTEN Regulation","Mitotic Metaphase and Anaphase","Transcriptional regulation by RUNX
1","RET signaling","Golgi Associated Vesicle Biogenesis","Glycogen breakdown (glycogenolysis)","Signaling by FGFR3 in disease","G1 Phase","Signaling by FGFR4","Drug resistance of PDGFR mutants","PTK6 
promotes HIF1A stabilization","Signaling by ROBO receptors","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 2 (TLR2) Cascade","RHO GTPases activate CIT","HIV Life Cycle","Tr
anscriptional Regulation by TP53","Transcriptional regulation by RUNX3","Transcriptional Regulation by MECP2","Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","FGFR1 mu
tant receptor activation","VEGF binds to VEGFR leading to receptor dimerization","Gastrin-CREB signalling pathway via PKC and MAPK","VEGFR2 mediated cell proliferation",PI5P,"PP2A and IER3 Regulate PI
3K/AKT Signaling","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis","Signaling downstream of RAS mutants","EPHA-mediated growth cone collapse","FGFR2 mutant receptor
 activation","EPHB-mediated forward signaling","Anti-inflammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","MyD88 cascade initiated on plasma membrane","Centr
osome maturation","IRS-mediated signalling","Dasatinib-resistant KIT mutants","Leishmania phagocytosis","Regulation of PTEN stability and activity","Mitotic Anaphase","RUNX1 regulates transcription of
 genes involved in BCR signaling","Signaling by FGFR3 point mutants in cancer","Cyclin D associated events in G1","Negative regulation of FGFR4 signaling","Imatinib-resistant PDGFR mutants","Role of A
BL in ROBO-SLIT signaling","Post NMDA receptor activation events","Toll Like Receptor TLR6:TLR2 Cascade","Late Phase of HIV Life Cycle","Regulation of TP53 Activity","Downstream signaling of activated
 FGFR4","RUNX3 Regulates Immune Response and Cell Migration","Signalling to ERK5","Regulation of MECP2 expression and activity","TFAP2 (AP-2) family regulates transcription of growth factors and their
 receptors","Signaling by activated point mutants of FGFR1","EGFR Transactivation by Gastrin","Prolonged ERK activation events","Nef and signal transduction","Activated point mutants of FGFR2","FCGR3A
-mediated IL10 synthesis","Sema4D induced cell migration and growth-cone collapse","MAP kinase activation","Signalling to RAS","Loss of proteins required for interphase microtubule organization from t
he centrosome","PI3K Cascade","FCGR3A-mediated phagocytosis","Separation of Sister Chromatids","Sema4D mediated inhibition of cell attachment and migration","Nef-mediates down modulation of cell surfa
ce receptors by recruiting them to clathrin adapters","FGFR3 mutant receptor activation","Spry regulation of FGF signaling","Long-term potentiation","MyD88:MAL(TIRAP) cascade initiated on plasma membr
ane","Transcription of the HIV genome","Regulation of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","FRS-mediated FGFR4 sign
aling","Frs2-mediated activation","activated TAK1 mediates p38 MAPK activation","p38MAPK events","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Medi
ated CD4 Down-regulation","Signaling by activated point mutants of FGFR3","HIV Transcription Elongation","RSK activation","CREB phosphorylation","Activation of the AP-1 family of transcription factors
","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{EGFR,EPHA1,EPHA10,EPHA2,EPHA3,EPHA4,EPHA5,EPHA6,EPHA7,EPHA8,EPHB1,EPHB2,EPHB3,EPHB4,EPHB6,ERBB2,ERBB3,ERBB4,FLT1,FLT4,KDR,PTK6,RET,SRC,TEK,VEGFA}

> <broad_moa>
{"EGFR inhibitor","RET tyrosine kinase inhibitor","VEGFR inhibitor"}

> <synonyms>
{Vandetinib,"HSDB 8198",2ivu,Vandetanib,443913-73-3,443913733,Zactima,ZD6474,Caprelsa,"vandetanib (zd6474)","ZD 6474",ZD-6474,UNII-YO460OQ37K,UNIIYO460OQ37K,C22H24BrFN4O2,CHEMBL24828,YO460OQ37K,CHEBI:
49960,GNF-PF-2188,GNFPF2188,MFCD07772346,NCGC00167513-01,NCGC0016751301,DSSTox_CID_26681,DSSToxCID26681,DSSTox-CID-26681,"DSSTox CID 26681",DSSTox,T1656,760766,S1046,"NSC 760766",vandetanib,VANDETANIB
}

> <pdid>
PD003329

> <targets>
{"EGFR(HER) | VEGFR-PDGFR",PDGFR,RET,KIT,VEGFR,FMS}

> <classes>
{"Kinase inhibitor"}

> <pubchem_cids>
{3081361}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
   -6.5549   14.2435    0.0000 C   0  0
   -6.5458   12.7435    0.0000 N   0  0
   -5.2423   12.0014    0.0000 C   0  0
   -5.2332   10.5014    0.0000 C   0  0
   -6.5277    9.7436    0.0000 N   0  0
   -7.8313   10.4858    0.0000 C   0  0
   -7.8403   11.9857    0.0000 C   0  0
   -6.5187    8.2429    0.0000 C   0  0
   -5.2163    7.4985    0.0000 C   0  0
   -5.2097    5.9985    0.0000 C   0  0
   -6.5054    5.2428    0.0000 C   0  0
   -6.5018    3.7420    0.0000 N   0  0
   -7.7993    2.9876    0.0000 C   0  0
   -9.1021    3.7310    0.0000 N   0  0
  -10.3974    2.9744    0.0000 C   0  0
  -10.3898    1.4745    0.0000 C   0  0
  -11.6850    0.7179    0.0000 Cl  0  0
   -9.0870    0.7310    0.0000 C   0  0
   -9.0763   -0.7698    0.0000 O   0  0
   -7.7717   -1.5117    0.0000 C   0  0
   -7.7589   -3.0117    0.0000 C   0  0
   -6.4535   -3.7506    0.0000 C   0  0
   -5.1609   -2.9896    0.0000 C   0  0
   -5.1737   -1.4897    0.0000 C   0  0
   -3.8819   -0.7256    0.0000 N   0  0
   -3.8968    0.7752    0.0000 C   0  0
   -5.2035    1.5118    0.0000 O   0  0
   -2.6051    1.5393    0.0000 C   0  0
   -2.6200    3.0392    0.0000 C   0  0
   -6.4790   -0.7508    0.0000 C   0  0
   -7.7918    1.4876    0.0000 N   0  0
   -7.8077    5.9870    0.0000 C   0  0
   -7.8144    7.4870    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  2  0
 24 30  2  0
 30 20  1  0
 18 31  2  0
 31 13  1  0
 11 32  1  0
 32 33  2  0
 33  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28412

> <plate>
Kinase v5-2

> <well>
A17

> <supplier_cmpd_name>
WZ3146

> <ctcr_id>
1931

> <supplier_cmpd_id>
S1170

> <smiles>
CN1CCN(CC1)c2ccc(Nc3ncc(Cl)c(Oc4cccc(NC(=O)C=C)c4)n3)cc2

> <pd_targets>
{EGFR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by GPCR","GPCR downstream signalling","G alpha (q) signalling events","Gastrin-CREB signalling pathway via PKC and MAPK","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{W-5698,W5698,"W 5698",J-523323,J523323,"J 523323",BRD-K73293050-001-01-5,BRDK73293050001015,"BRD K73293050 001 01 5",Q27166520,1214265-56-1,1214265561,"1214265 56 1",WZ3146,WZ-3146,"WZ 3146",C24H25Cl
N6O2,SCHEMBL93510,cc-597,cc597,"cc 597",MLS0060112,S1170}

> <pdid>
PD003311

> <targets>
{EGFR(HER),EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{44607360}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 38  0  0  0  0            999 V2000
    3.9068   -0.7607    0.0000 C   0  0
    2.6046   -1.5052    0.0000 O   0  0
    2.5973   -3.0060    0.0000 C   0  0
    3.8942   -3.7597    0.0000 C   0  0
    3.8899   -5.2597    0.0000 C   0  0
    2.5887   -6.0060    0.0000 C   0  0
    1.2918   -5.2523    0.0000 C   0  0
    1.2961   -3.7523    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 N   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2089   -5.9859    0.0000 Cl  0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -5.1977   -2.9829    0.0000 O   0  0
   -5.1903   -1.4821    0.0000 C   0  0
   -6.4841   -0.7230    0.0000 C   0  0
   -6.4738    0.7769    0.0000 C   0  0
   -5.1696    1.5179    0.0000 C   0  0
   -3.8758    0.7590    0.0000 C   0  0
   -2.5693    1.4977    0.0000 N   0  0
   -1.2759    0.7365    0.0000 C   0  0
   -1.2888   -0.7634    0.0000 O   0  0
    0.0306    1.4752    0.0000 C   0  0
    1.3233    0.7144    0.0000 C   0  0
   -3.8861   -0.7410    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 N   0  0
    5.1874   -6.0137    0.0000 N   0  0
    6.4899   -5.2696    0.0000 C   0  0
    7.7856   -6.0253    0.0000 C   0  0
    7.7789   -7.5253    0.0000 N   0  0
    9.0746   -8.2811    0.0000 C   0  0
    6.4766   -8.2695    0.0000 C   0  0
    5.1809   -7.5138    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  2  0
 21 27  2  0
 27 17  1  0
 15 28  2  0
 28 10  1  0
  5 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 32 34  1  0
 34 35  1  0
 35 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28413

> <plate>
Kinase v5-2

> <well>
A19

> <supplier_cmpd_name>
WZ4002

> <ctcr_id>
1735

> <supplier_cmpd_id>
S1173

> <smiles>
COc1cc(ccc1Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)N4CCN(C)CC4

> <pd_targets>
{EGFR,ALK,JAK3,ERBB2,ERBB3,ERBB4,ITK,CTSC,BTK,BLK,NUAK1,ABL1,EML4}

> <pathway_gtopdb>
{Enzyme,Kinase,Protease,"Protein Kinase","Cysteine protease","TK protein kinase group","TKL protein kinase group","Cysteine protease CA clan","CAMK protein kinase group","Tyrosine protein kinase EGFR 
family","TKL protein kinase STKR family","Tyrosine protein kinase JakA family","Tyrosine protein kinase Tec family","Cysteine protease C1A family","Tyrosine protein kinase Src family","CAMK protein ki
nase CAMK1 family","Tyrosine protein kinase Abl family","TKL protein kinase STKR Type 1 subfamily","CAMK protein kinase NuaK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Peptidases and proteinases","Kinases (EC 2.7.x.x)","Receptor kinases","CA: Cysteine (C) Peptidases","CAMK: Calcium/calmodulin-dependent protein kinases","TK: 
Tyrosine kinase","C1: Papain","CAMK-like (CAMKL) family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","NuaK subfamily","Type I RTKs: ErbB (epidermal growth factor) recept
or family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Janus kinase (JakA) family","Tec family","Src family","Abl family"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Metabolism of proteins",Disease,"Gene expression (Transcription)","Neuronal System","Signaling by GPCR","Cytokine Signaling in Immune system","Adaptive Immune S
ystem","Post-translational protein modification","Infectious disease","RNA Polymerase II Transcription","Transmission across Chemical Synapses","GPCR downstream signalling","Signaling by Interleukins"
,"TCR signaling","Asparagine N-linked glycosylation","Leishmania infection","Generic Transcription Pathway","Neurotransmitter receptors and postsynaptic signal transmission","G alpha (q) signalling ev
ents","Interleukin-2 family signaling","Generation of second messenger molecules","Transport to the Golgi and subsequent modification","Parasite infection","Transcriptional regulation by RUNX1","Trans
criptional Regulation by TP53","Activation of NMDA receptors and postsynaptic events","Gastrin-CREB signalling pathway via PKC and MAPK","Interleukin-15 signaling","ER to Golgi Anterograde Transport",
"Leishmania phagocytosis","RUNX1 regulates transcription of genes involved in BCR signaling","Regulation of TP53 Activity","Post NMDA receptor activation events","EGFR Transactivation by Gastrin","Car
go concentration in the ER","FCGR3A-mediated phagocytosis","Regulation of TP53 Activity through Phosphorylation","Long-term potentiation"}

> <broad_targets>
{EGFR,ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{WZ4002,1213269-23-8,1213269238,WZ-4002,"WZ 4002",UNII-6BQ432Z61M,UNII6BQ432Z61M,CHEBI:61400,CHEMBL1229592,6BQ432Z61M,SMR001913510,SCHEMBL93699,cc-192,cc192,MLS003230945,MLS006011213,AMY370,GTPL9176,Q
CR-55,QCR55,DTXSID30153230,EX-A416,EXA416,HMS3265O15,HMS3265O16,HMS3265P15,HMS3265P16,HMS3654C,T6238,S1173}

> <pdid>
PD003346

> <targets>
{NULL,EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{44607530}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
   -6.5549   14.2435    0.0000 C   0  0
   -6.5458   12.7435    0.0000 N   0  0
   -5.2423   12.0014    0.0000 C   0  0
   -5.2332   10.5014    0.0000 C   0  0
   -6.5277    9.7436    0.0000 N   0  0
   -7.8313   10.4858    0.0000 C   0  0
   -7.8403   11.9857    0.0000 C   0  0
   -6.5187    8.2429    0.0000 C   0  0
   -5.2163    7.4985    0.0000 C   0  0
   -5.2097    5.9985    0.0000 C   0  0
   -6.5054    5.2428    0.0000 C   0  0
   -6.5018    3.7420    0.0000 N   0  0
   -7.7993    2.9876    0.0000 C   0  0
   -9.1021    3.7310    0.0000 N   0  0
  -10.3974    2.9744    0.0000 C   0  0
  -10.3898    1.4745    0.0000 C   0  0
  -11.6850    0.7179    0.0000 Cl  0  0
   -9.0870    0.7310    0.0000 C   0  0
   -9.0763   -0.7698    0.0000 S   0  0
   -7.7717   -1.5117    0.0000 C   0  0
   -7.7589   -3.0117    0.0000 C   0  0
   -6.4535   -3.7506    0.0000 C   0  0
   -5.1609   -2.9896    0.0000 C   0  0
   -5.1737   -1.4897    0.0000 C   0  0
   -3.8819   -0.7256    0.0000 N   0  0
   -3.8968    0.7752    0.0000 C   0  0
   -5.2035    1.5118    0.0000 O   0  0
   -2.6051    1.5393    0.0000 C   0  0
   -2.6200    3.0392    0.0000 C   0  0
   -6.4790   -0.7508    0.0000 C   0  0
   -7.7918    1.4876    0.0000 N   0  0
   -7.8077    5.9870    0.0000 C   0  0
   -7.8144    7.4870    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  2  0
 24 30  2  0
 30 20  1  0
 18 31  2  0
 31 13  1  0
 11 32  1  0
 32 33  2  0
 33  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28414

> <plate>
Kinase v5-2

> <well>
A21

> <supplier_cmpd_name>
WZ8040

> <ctcr_id>
418

> <supplier_cmpd_id>
S1179

> <smiles>
CN1CCN(CC1)c2ccc(Nc3ncc(Cl)c(Sc4cccc(NC(=O)C=C)c4)n3)cc2

> <pd_targets>
{EGFR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by GPCR","GPCR downstream signalling","G alpha (q) signalling events","Gastrin-CREB signalling pathway via PKC and MAPK","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{WZ8040,1214265-57-2,1214265572,WZ-8040,"WZ 8040",C24H25ClN6OS,SCHEMBL93523,cc-536,cc536,MLS006011280,CHEMBL1643989,DTXSID40659652,HMS3654M16,BCP02320,EX-A4023,EXA4023,ABP000885,s1179,ZINC52509388,CCG
-269557,CCG269557,CS-0171,CS0171,SB19363,WZ8040/WZ-8040,WZ8040/WZ8040,NCGC00346497-01,NCGC0034649701,NCGC00346497-02,NCGC0034649702,AC-3,AC3,T6733,S1179,WZ3146}

> <pdid>
PD003311

> <targets>
{EGFR(HER),EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{44607531}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    7.7947   -3.0293    0.0000 C   0  0
    6.4915   -3.7721    0.0000 N   0  0
    5.1954   -3.0153    0.0000 C   0  0
    5.2033   -1.5153    0.0000 O   0  0
    3.8915   -3.7585    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.1905    2.6376    0.0000 C   0  0
   -4.6589    2.9478    0.0000 C   0  0
   -5.1253    4.3743    0.0000 C   0  0
   -6.5925    4.6865    0.0000 C   0  0
   -7.0558    6.1131    0.0000 C   0  0
   -6.0520    7.2277    0.0000 C   0  0
   -4.5848    6.9156    0.0000 C   0  0
   -4.1215    5.4889    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 15  1  0
 19 20  1  0
 20 21  2  3
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 16 28  2  0
 28 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28415

> <plate>
Kinase v5-2

> <well>
C03

> <supplier_cmpd_name>
Axitinib

> <ctcr_id>
4551

> <supplier_cmpd_id>
S1005

> <smiles>
CNC(=O)c1ccccc1Sc2ccc3c([nH]nc3C=Cc4ccccn4)c2

> <pd_targets>
{MARK2,MAP3K20,CDK2,FLT1,PDPK1,DCLK1,ALK,AXL,LCK,SRPK1,TYK2,PKN2,STK3,TBK1,CSNK2A1,PDGFRA,CAMK2D,NTRK2,MAP4K5,RET,PRKAA1,PDGFRB,IRAK1,PAK4,MAP4K2,TSSK1B,IKBKE,BRSK1,RPS6KA3,MAP4K4,MET,KIT,AURKA,BLK,MK
NK2,SLK,PLK4,PHKG2,LYN,FGFR1,CSF1R,MAPK14,LIMK1,ABL1,FLT4,FGFR3,MST1R,CAMK2G,RPS6KB1,LRRK2,ROCK2,KDR,AURKB,MARK3,MINK1,GAK,MAP3K4,FLT3,HUNK,AAK1,TNIK,GRK4,BMPR1B,DDR2,MAPK8,JAK3,EGFR,STK4,RIPK1,NUAK2,
YES1,TESK1,SRPK3,MAP3K9,ACVR2B,ULK2,BMP2K,MAP3K19,ANKK1,MYLK3,CAMKK2,RIPK2,EIF2AK2,MAP4K3,STK16,DDR1,CDKL2,AURKC,CSNK2A2,TIE1,CDK16,RIPK4,FGFR2,CDC42BPB,ABL2,JAK2,MYO3A,SIK1,RIOK3,MAP2K1,TTK,MAPK10,RO
S1,TNK1,MAP4K1,MAP2K2,RIOK1,MYLK2,MERTK,ULK3,TXK,MAP3K12,MAP2K5,STK10,MAP3K3,FGR,CSK,CAMKK1,EPHB6,NTRK1,TEK,ITK,TNK2}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","CAMK protein kinase group","TKL protein kinase group","CMGC protein kinase group","TK protein kinase group","AGC protein kinase group","STE prot
ein kinase group","Other protein kinase group","Atypical protein kinase group","CAMK protein kinase CAMK1 family","TKL protein kinase MLK family","CMGC protein kinase CDK family","Tyrosine protein kin
ase VEGFR family","AGC protein kinase PDK1 subfamily","CAMK protein kinase DCAMK1 family","TKL protein kinase STKR family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Src family","CM
GC protein kinase SRPK family","Tyrosine protein kinase JakA family","AGC protein kinase PKN family","STE protein kinase STE20 family","Other protein kinase IKK family","Other protein kinase CK2 famil
y","Tyrosine protein kinase PDGFR family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Trk family","Tyrosine protein kinase Ret family","TKL protein kinase IRAK family","CAMK protein ki
nase TSSK family","AGC protein kinase RSK family","Tyrosine protein kinase Met family","Other protein kinase AUR family","CAMK protein kinase MAPKAPK family","Other protein kinase PLK family","CAMK pr
otein kinase PHk family","Tyrosine protein kinase FGFR family","CMGC protein kinase MAPK family","TKL protein kinase LISK family","Tyrosine protein kinase Abl family","TKL protein kinase LRRK family",
"AGC protein kinase DMPK family","Other protein kinase NAK family","STE protein kinase STE11 family","AGC protein kinase GRK family","Tyrosine protein kinase DDR family","Tyrosine protein kinase EGFR 
family","TKL protein kinase RIPK family","Other protein kinase ULK family","CAMK protein kinase MLCK family","Other protein kinase CAMKK family","Other protein kinase PEK family","CMGC protein kinase 
CDKL family","Tyrosine protein kinase Tie family","Atypical protein kinase RIO family","STE protein kinase STE7 family","Other protein kinase TTK family","Tyrosine protein kinase Sev family","Tyrosine
 protein kinase Ack family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Csk family","CAMK protein kinase MARK subfamily","TKL protein kinase MLK subfamily","CMGC protein kinase CDC2 
subfamily","TKL protein kinase STKR Type 1 subfamily","STE protein kinase MST subfamily","STE protein kinase KHS subfamily","CAMK protein kinase AMPK subfamily","STE protein kinase PAKB subfamily","CA
MK protein kinase BRSK subfamily","AGC protein kinase RSK subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MNK subfamily","STE protein kinase SLK subfamily","CMGC protein kinase p38 
subfamily","TKL protein kinase LIMK subfamily","AGC protein kinase p70 subfamily","AGC protein kinase ROCK subfamily","AGC protein kinase GRK subfamily","CMGC protein kinase JNK subfamily","CAMK prote
in kinase NuaK subfamily","TKL protein kinase TESK subfamily","TKL protein kinase STKR Type 2 subfamily","Other protein kinase Meta subfamily","Other protein kinase PKR","CMGC protein kinase TAIRE sub
family","AGC protein kinase GEK subfamily","STE protein kinase NinaC subfamily","CAMK protein kinase QIK subfamily","Atypical protein kinase RIO3 subfamily","Atypical protein kinase RIO1 subfamily","S
TE protein kinase MEKK2"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing
 PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Atypical,"CAMK-like (CAMKL) family","TKL: Tyrosine kinase-like","Cyclin-dependent kinase (CDK) family","TK
: Tyrosine kinase","PDK1 family","DCAMKL family","SRPK family","Protein kinase N (PKN) family","STE20 family","Other protein kinases","CAMK2 family","Testis specific kinase (TSSK) family","RSK family"
,"MAPK-Activated Protein Kinase (MAPKAPK) family","Phosphorylase kinase (PHK) family","Mitogen-activated protein kinases (MAP kinases)","DMPK family","STE11 family","G protein-coupled receptor kinases
 (GRKs)","Myosin Light Chain Kinase (MLCK) family","Cyclin-dependent kinase-like (CDKL) family","RIO family","STE7 family","MARK subfamily","Mixed Lineage Kinase (MLK) family","CDK1 subfamily","Recept
or tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","MST subfamily","IKK family","Casein kinase 2 (CK2) family","KHS subfamily","AMPK subfamily","Interleukin-1 receptor-associated kina
se (IRAK) family","PAKB subfamily","BRSK subfamily","RSK subfamily","MSN subfamily","Aurora kinase (Aur) family","MKN subfamily","SLK subfamily","Polo-like kinase (PLK) family","p38 subfamily","LIM do
main kinase (LISK) family","p70 subfamily","Leucine-rich repeat kinase (LRRK) family","Rho kinase","Numb-associated kinase (NAK) family","HUNK subfamily","NAK family","GRK4 subfamily","Receptor serine
/threonine kinase (RSTK) family","JNK subfamily","Receptor interacting protein kinase (RIPK) family","NuaK subfamily","Unc-51-like kinase (ULK) family","STE20 subfamily","CAMKK family","PEK family","T
AIRE subfamily","GEK subfamily","NinaC subfamily","QIK subfamily","RIO3 subfamily","TTK family","RIO1 subfamily","MLK subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor famil
y","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Src family","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR
,Kit,"FLT3 receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XIV RTKs: RET","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type V RTKs: FGF (fibroblast growth fa
ctor) receptor family","LIMK subfamily","Abl family","Type I receptor serine/threonine kinases","Type XVI RTKs: DDR (collagen receptor) family","Type I RTKs: ErbB (epidermal growth factor) receptor fa
mily","TESK subfamily","Type II receptor serine/threonine kinases","Meta subfamily","Other PEK family kinases","Type XII RTKs: TIE family of angiopoietin receptors","Type XVII RTKs: ROS receptors","Ac
k family","Tec family","LZK subfamily","Csk family","Type XIII RTKs: Ephrin receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction",Disease,"Immune System","Neuronal System","Developmental Biology","Cellular responses to external stimuli","Cell Cycle",Metabolism,"Vesicle-med
iated transport","Extracellular matrix organization","Cell-Cell communication","Circadian Clock","Metabolism of RNA",Hemostasis,"RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinase
s","Infectious disease","Cytokine Signaling in Immune system","Signaling by Rho GTPases","Signaling by Hippo","Innate Immune System","Diseases of signal transduction by growth factor receptors and sec
ond messengers","Transmission across Chemical Synapses","Nervous system development","Intracellular signaling by second messengers","Cellular responses to stress",Mitotic,"Metabolism of carbohydrates"
,"MTOR signalling","Signaling by Non-Receptor Tyrosine Kinases","Membrane Trafficking","Signaling by GPCR","Signaling by TGFB family members","Non-integrin membrane-ECM interactions","Cell junction or
ganization","Signaling by NODAL","rRNA processing","Cell surface interactions at the vascular wall","Signaling by Hedgehog","MAPK family signaling cascades","Adaptive Immune System","Generic Transcrip
tion Pathway","Signaling by VEGF","HIV Infection","Interferon Signaling","RHO GTPase Effectors","Toll-like Receptor Cascades","Signaling by PDGFR in disease","Neurotransmitter receptors and postsynapt
ic signal transmission","Signaling by NTRKs","Axon guidance","PIP3 activates AKT signaling","Cellular Senescence","Signaling by KIT in disease","Mitotic G2-G2/M phases","Glycogen metabolism","Leishman
ia infection","Signaling by FGFR in disease","Signaling by MST1","mTORC1-mediated signalling","Signaling by PTK6","M Phase","Oncogenic MAPK signaling","trans-Golgi Network Vesicle Budding","Signaling 
by Insulin receptor","Clathrin-mediated endocytosis","GPCR downstream signalling","Signaling by BMP","Signaling by Interleukins","Cell-extracellular matrix interactions","Regulation of signaling by NO
DAL","Influenza Infection","Mitotic G1 phase and G1/S transition","rRNA processing in the nucleus and cytosol","Hedgehog 'on' state","Fc epsilon receptor (FCERI) signaling","Neutrophil degranulation",
"MAPK1/MAPK3 signaling","TCR signaling","Transcriptional Regulation by TP53","VEGF ligand-receptor interactions","VEGFA-VEGFR2 Pathway","Host Interactions of HIV factors","Interferon alpha/beta signal
ing","RHO GTPases activate PKNs","Toll Like Receptor 4 (TLR4) Cascade","Drug resistance of PDGFR mutants","Activation of NMDA receptors and postsynaptic events","Signaling by NTRK1 (TRKA)","RET signal
ing","Negative regulation of the PI3K/AKT network","Toll Like Receptor 5 (TLR5) Cascade","Signaling by ROBO receptors","Oxidative Stress Induced Senescence","Semaphorin interactions","Drug resistance 
of KIT mutants","Transcriptional regulation by RUNX1","G2/M Transition","Glycogen breakdown (glycogenolysis)","Leishmania parasite growth and survival","Signaling by FGFR1 in disease","Transcriptional
 Regulation by VENTX","Parasite infection","Signaling by FGFR3 in disease","PTK6 promotes HIF1A stabilization","Mitotic Metaphase and Anaphase","Signaling by RAS mutants","Golgi Associated Vesicle Bio
genesis","Insulin receptor signalling cascade","Cargo recognition for clathrin-mediated endocytosis","G alpha (i) signalling events","Interleukin-2 family signaling","G alpha (q) signalling events","R
egulation of cytoskeletal remodeling and cell spreading by IPP complex components","NS1 Mediated Effects on Host Pathways","Signaling by FGFR2 in disease","G1 Phase","Major pathway of rRNA processing 
in the nucleolus and cytosol","FCERI mediated Ca+2 mobilization","Interleukin-1 family signaling","EPH-Ephrin signaling","RAF/MAP kinase cascade","Generation of second messenger molecules","Regulation
 of TP53 Activity","VEGF binds to VEGFR leading to receptor dimerization","The role of Nef in HIV-1 replication and disease pathogenesis","Regulation of IFNA signaling","MyD88-independent TLR4 cascade
","Imatinib-resistant PDGFR mutants","Post NMDA receptor activation events","Activation of TRKA receptors",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","MyD88 cascade initiated on plasma membrane"
,"Activation of RAC1","Sema4D in semaphorin signaling","Dasatinib-resistant KIT mutants","RUNX1 regulates transcription of genes involved in BCR signaling","Centrosome maturation","Anti-inflammatory r
esponse favouring Leishmania parasite infection","FGFR1 mutant receptor activation","Leishmania phagocytosis","Signaling by FGFR3 point mutants in cancer","VEGFR2 mediated cell proliferation","Mitotic
 Anaphase","Signaling downstream of RAS mutants","IRS-mediated signalling","Visual phototransduction","Interleukin-15 signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Inhibition of PKR",
"FGFR2 mutant receptor activation","Role of ABL in ROBO-SLIT signaling","Cyclin D associated events in G1","Signalling to ERKs","Signalling to ERK5","Interleukin-1 signaling","EPHB-mediated forward si
gnaling","Regulation of TP53 Expression and Degradation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","TRIF(TICAM1)-mediated TLR4 signaling","Regula
tion of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","NGF-independant TRKA activation","MAP kinase activation","Sema4D medi
ated inhibition of cell attachment and migration","Loss of proteins required for interphase microtubule organization from the centrosome","FCGR3A-mediated IL10 synthesis","Signaling by activated point
 mutants of FGFR1","Sema4D induced cell migration and growth-cone collapse","FCGR3A-mediated phagocytosis","FGFR3 mutant receptor activation","Separation of Sister Chromatids","PI3K Cascade","The phot
otransduction cascade","EGFR Transactivation by Gastrin","Activation of AMPK downstream of NMDARs","Activated point mutants of FGFR2","Prolonged ERK activation events","Activation of RAC1 downstream o
f NMDARs","Regulation of TP53 Degradation","Nef Mediated CD4 Down-regulation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Ras activation upon Ca2+ influx through NMDA receptor","activated 
TAK1 mediates p38 MAPK activation","MAPK targets/ Nuclear events mediated by MAP kinases","Loss of Nlp from mitotic centrosomes","Signaling by activated point mutants of FGFR3",Inactivation,"recovery 
and regulation of the phototransduction cascade","IKK complex recruitment mediated by RIP1","Frs2-mediated activation","ARMS-mediated activation","CREB phosphorylation","Activation of the AP-1 family 
of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{N-methyl-2-((3-(2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)thio)benzamide,Nmethyl2((3(2(2pyridinyl)ethenyl)1Hindazol6yl)thio)benzamide,Kinome_3641,Kinome3641,Kinome-3641,"Kinome 3641","Axitinib-(13C,d3)
","Axitinib(13C,d3)",CHEMBL1988437,HMS3244B04,HMS3244B08,HMS3244B12,HMS3654I03,HMS3674G15,1261432-00-1,1261432001,ANW-61822,ANW61822,AKOS030228495,NCGC00241108-03,NCGC0024110803,AK106979,FT-0659483,FT
0659483,Q,T1452,S1005,Axitinib,AXITINIB}

> <pdid>
PD003216

> <targets>
{VEGFR-PDGFR,KIT,VEGFR1/2/3,PDGFR}

> <classes>
{}

> <pubchem_cids>
{3086685}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.1905    2.6376    0.0000 C   0  0
   -4.6589    2.9478    0.0000 N   0  0
   -5.1253    4.3743    0.0000 C   0  0
   -6.5925    4.6864    0.0000 C   0  0
   -7.0558    6.1131    0.0000 C   0  0
   -6.0520    7.2277    0.0000 C   0  0
   -4.5848    6.9156    0.0000 C   0  0
   -4.1215    5.4889    0.0000 C   0  0
   -6.5126    8.6561    0.0000 N   0  0
   -7.9792    8.9707    0.0000 C   0  0
   -5.5066    9.7698    0.0000 C   0  0
   -4.0400    9.4552    0.0000 O   0  0
   -5.9672   11.1982    0.0000 C   0  0
   -4.9612   12.3120    0.0000 N   0  0
   -5.4195   13.7403    0.0000 C   0  0
   -4.4118   14.8513    0.0000 C   0  0
   -2.9457   14.5342    0.0000 N   0  0
   -1.9380   15.6453    0.0000 C   0  0
   -2.4873   13.1059    0.0000 C   0  0
   -3.4951   11.9948    0.0000 C   0  0
   -2.1880    3.7544    0.0000 C   0  0
   -2.6518    5.1810    0.0000 C   0  0
   -1.6483    6.2959    0.0000 C   0  0
   -0.1810    5.9844    0.0000 C   0  0
    0.2828    4.5579    0.0000 C   0  0
   -0.7207    3.4429    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1065    0.0000    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 26 28  1  0
 28 29  1  0
 29 23  1  0
 10 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
  9 36  1  0
 36 37  2  0
 36 38  1  0
 38 39  1  0
 39  8  1  0
 39 40  2  0
 40  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28416

> <plate>
Kinase v5-2

> <well>
C05

> <supplier_cmpd_name>
BIBF1120(Vargatef)

> <ctcr_id>
3358

> <supplier_cmpd_id>
S1010

> <smiles>
COC(=O)c1ccc2C(=C(Nc3ccc(cc3)N(C)C(=O)CN4CCN(C)CC4)c5ccccc5)C(=O)Nc2c1

> <pd_targets>
{PDGFRB,FGFR4,KDR,FGFR1,FLT4,FGFR3,PDGFRA,FLT1,FGFR2,FLT3,STK16,ACVRL1,BTK,MYO3B,RIPK4,GRK7,MAP3K7,SIK1,OXSR1,ABL1,FER,PRKG1,MAP3K12,TBK1,DAPK2,RPS6KA6,CILK1,SIK2,CDK7,CSNK2A1,CSNK2A2,HCK,MAP3K3,PAK2,
TYK2,CAMK1,EPHA2,EPHB6,STK35,CDK4,HIPK4,STK33,EPHA6,CDK14,CAMK1G,PRKAA1,PKNB,ERN1,KIT,CDK2,IKBKE,ABL2,MET,RET,CAMKK2,JAK1,BMPR2,CLK1,PRKD2,AXL,INSRR,EPHA1,HIPK3,STK3,TYRO3,MAP3K2,SGK3,SRPK3,BMP2K,CAMK
2A,PLK4,ACVR1B,MAP4K2,HIPK2,SLK,MAP4K4,DDR2,SRC,RPS6KA2,PAK4,SBK1,PIP5K1A,MAP2K2,NUAK2,MARK4,RIOK1,MYLK2,PTK2B,ZAP70,SBK3,MERTK,SRPK2,RPS6KA4,EIF2AK4,DAPK3,CAMK1D,TSSK1B,CAMKK1,DCLK3,LRRK2,LTK,PKN1,FR
K,GSK3B,MAP3K11,CLK2,RPS6KA3,DDR1,RIPK1,GRK4,IGF1R,MAST1,IRAK1,EPHA3,IRAK4,MAP4K3,INSR,PIP4K2B,GSC2,BLK,CAMK4,MARK3,RPS6KB1,ULK1,DCLK1,PRKCQ,PAK5,PRKD3,PKN2,MAP4K1,SRPK1,FGR,NTRK2,GSK3A,ALK,ULK2,YES1,
MUSK,MAP4K5,IRAK3,LATS2,NUAK1,CHEK1,NTRK1,PRKD1,MAP3K19,STK11,RPS6KA5,ITK,STK26,JAK3,HIPK1,ULK3,MAP3K15,CLK4,MAP3K9,MYLK,MYLK3,AURKC,AURKB,TNK2,CDPK1,MAPK8,MAP2K3,TXK,CDKL2,DYRK1B,MAP3K10,MAPK7,PAK3,N
TRK3,TIE1,CDK16,STK10,MARK2,MARK1,MAPK10,MAPK14,LATS1,MAP2K1,ROS1,MAP2K4,STK24,RIOK3,STK17A,MAP2K5,WEE1,FES,ACVR1,LCK,GRK1,PDPK1,EPHB1,CDK17,MYLK4,MINK1,FYN,JAK2,CSF1R,PHKG1,STK39,TNIK,MELK,CHUK,PRKAA
2,PRPF4B,TEK,CDK18,EPHB4,TGFBR1,MAP3K13,AAK1,RPS6KA1,LYN,PTK2,STK17B,CSNK1D,TNK1,PHKG2,CSNK1E,TTK,KCNH2,STK4,ABCB1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Ion channel",Transporter,Kinase,Transferase,"Voltage-gated ion channel","Primary active transporter","Protein Kinase","Potassium channels","ATP-binding cassette","TK pr
otein kinase group","Other protein kinase group","TKL protein kinase group","STE protein kinase group","AGC protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Atypical prot
ein kinase group","CK1 protein kinase group","Voltage-gated potassium channel","ABCB subfamily","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase VE
GFR family","Other protein kinase NAK family","TKL protein kinase STKR family","Tyrosine protein kinase Tec family","STE protein kinase STE20 family","TKL protein kinase RIPK family","AGC protein kina
se GRK family","TKL protein kinase MLK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Fer family","AGC protein kinase PKG family","Other prote
in kinase IKK family","CAMK protein kinase DAPK family","AGC protein kinase RSK family","CMGC protein kinase RCK family","CMGC protein kinase CDK family","Other protein kinase CK2 family","Tyrosine pr
otein kinase Src family","STE protein kinase STE11 family","Tyrosine protein kinase JakA family","Tyrosine protein kinase Eph family","Other protein kinase NKF4 family","CMGC protein kinase DYRK famil
y","CAMK protein kinase unique family","Tyrosine protein kinase Met family","Tyrosine protein kinase Ret family","Other protein kinase CAMKK family","CMGC protein kinase CLK family","CAMK protein kina
se PKD family","Tyrosine protein kinase Axl family","Tyrosine protein kinase InsR family","AGC protein kinase SGK family","CMGC protein kinase SRPK family","CAMK protein kinase CAMK2 family","Other pr
otein kinase PLK family","Tyrosine protein kinase DDR family","Other protein kinase NKF1 family","STE protein kinase STE7 family","Atypical protein kinase RIO family","CAMK protein kinase MLCK family"
,"Tyrosine protein kinase Fak family","Tyrosine protein kinase Syk family","Other protein kinase PEK family","CAMK protein kinase TSSK family","CAMK protein kinase DCAMK1 family","TKL protein kinase L
RRK family","Tyrosine protein kinase Alk family","AGC protein kinase PKN family","CMGC protein kinase GSK family","AGC protein kinase MAST family","TKL protein kinase IRAK family","Other protein kinas
e ULK family","AGC protein kinase PKC family","Tyrosine protein kinase Trk family","Tyrosine protein kinase Musk family","AGC protein kinase NDR family","Other protein kinase AUR family","Tyrosine pro
tein kinase Ack family","CMGC protein kinase MAPK family","CMGC protein kinase CDKL family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Sev family","Other protein kinase WEE family",
"AGC protein kinase PDK1 subfamily","CAMK protein kinase PHk family","CK1 protein kinase CK1 family","Other protein kinase TTK family","TKL protein kinase STKR Type 1 subfamily","STE protein kinase Ni
naC subfamily","AGC protein kinase GRK subfamily","TKL protein kinase TAK1 subfamily","CAMK protein kinase QIK subfamily","STE protein kinase FRAY subfamily","AGC protein kinase RSK subfamily","CMGC p
rotein kinase MAK","CMGC protein kinase CDK7 subfamily","STE protein kinase MEKK2","STE protein kinase PAKA subfamily","CMGC protein kinase HIPK subfamily","CMGC protein kinase PFTAIRE","CAMK protein 
kinase AMPK subfamily","CMGC protein kinase CDC2 subfamily","Other protein kinase Meta subfamily","TKL protein kinase STKR Type 2 subfamily","STE protein kinase MST subfamily","STE protein kinase KHS 
subfamily","STE protein kinase SLK subfamily","STE protein kinase MSN subfamily","STE protein kinase PAKB subfamily","CAMK protein kinase NuaK subfamily","CAMK protein kinase MARK subfamily","Atypical
 protein kinase RIO1 subfamily","AGC protein kinase MSK subfamily","Other protein kinase GCN2 subfamily","TKL protein kinase MLK subfamily","AGC protein kinase p70 subfamily","AGC protein kinase PKC d
elta subfamily","CAMK protein kinase CHK1 subfamily","CAMK protein kinase LKB subfamily","STE protein kinase YSK subfamily","STE protein kinase ASK","CMGC protein kinase JNK subfamily","CMGC protein k
inase Dyrk1 subfamily","CMGC protein kinase ERK5","CMGC protein kinase TAIRE subfamily","CMGC protein kinase p38 subfamily","Atypical protein kinase RIO3 subfamily","TKL protein kinase STKR1","CMGC pr
otein kinase PCTAIRE","Tyrosine protein kinase SrcA","CAMK protein kinase MELK subfamily","TKL protein kinase LZK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels",Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)","Voltage-gated ion channels","ATP-binding cassette transporter family","Receptor kinases","STE: Homologs of 
yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Lipid 
modifying kinases",Atypical,"CK1: Casein kinase 1","Potassium channels","ABCB subfamily","TK: Tyrosine kinase","Other protein kinases","TKL: Tyrosine kinase-like","STE20 family","G protein-coupled rec
eptor kinases (GRKs)","CAMK-like (CAMKL) family","Protein kinase G (PKG) family","Death-associated kinase (DAPK) family","RSK family","RCK family","Cyclin-dependent kinase (CDK) family","STE11 family"
,"CAMK1 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CAMK-unique family","CLK family","Protein kinase D (PKD) family","SGK family","SRPK family","CAMK2 famil
y","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","STE7 family","RIO family","Myosin Light Chain Kinase (MLCK) family","Testis specific kinase (TSSK) family","DCAMKL family"
,"Protein kinase N (PKN) family","Glycogen synthase kinase (GSK) family","MAST family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Protein kinase C (PKC) family","NDR f
amily","Mitogen-activated protein kinases (MAP kinases)","Cyclin-dependent kinase-like (CDKL) family","PDK1 family","Phosphorylase kinase (PHK) family","Casein kinase 1 (CK1) family","Voltage-gated po
tassium channels","Receptor tyrosine kinases (RTKs)","NAK family","Receptor serine/threonine kinase (RSTK) family","Non-receptor tyrosine kinases (nRTKs)","NinaC subfamily","Receptor interacting prote
in kinase (RIPK) family","Opsin/rhodopsin kinases","Mixed Lineage Kinase (MLK) family","QIK subfamily","FRAY subfamily","IKK family","RSK subfamily","CDK7 subfamily","Casein kinase 2 (CK2) family","PA
KA subfamily","NKF4 family","CDK4 subfamily","HIPK subfamily","TAIRE subfamily","AMPK subfamily","IRE family","CDK1 subfamily","CAMKK family","MST subfamily","Numb-associated kinase (NAK) family","Pol
o-like kinase (PLK) family","KHS subfamily","SLK subfamily","MSN subfamily","PAKB subfamily","NKF1 family","NuaK subfamily","MARK subfamily","RIO1 subfamily","MSK subfamily","PEK family","Leucine-rich
 repeat kinase (LRRK) family","GSK subfamily","GRK4 subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","p70 subfamily","Unc-51-like kinase (ULK) family","Delta subfamily","CHK1 subfam
ily","STE20 subfamily","LKB subfamily","YSK subfamily","Aurora kinase (Aur) family","JNK subfamily","Dyrk1 subfamily","ERK subfamily","p38 subfamily","RIO3 subfamily","WEE family","MELK subfamily","PR
P4 subfamily","TTK family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor)
 receptor family","Type I receptor serine/threonine kinases","Tec family","TAK1 subfamily","Abl family","Fer family","LZK subfamily","Src family","Janus kinase (JakA) family","Type XIII RTKs: Ephrin r
eceptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIV RTKs: RET","Meta subfamily","Type II receptor serine/threonine kinases","Type XI RTKs: TAM (TYRO3-","AXL- and ME
R-TK) receptor family","Type II RTKs: Insulin receptor family","Type XVI RTKs: DDR (collagen receptor) family","Fak family","Syk family","GCN2 subfamily","Type XIX RTKs: Leukocyte tyrosine kinase (LTK
) receptor family","MLK subfamily","Type VII RTKs: Neurotrophin receptor/Trk family","Type IX RTKs: MuSK","Ack family","Type XII RTKs: TIE family of angiopoietin receptors","Type XVII RTKs: ROS recept
ors"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System","Circadian Clock",Hemostasis,"Programmed Cell Death","Neuronal System","Gene expression (Transcription)","Developmental Biology","Cell Cycle","Metabolism
 of proteins",Metabolism,"Transport of small molecules","Cellular responses to external stimuli","Extracellular matrix organization","Organelle biogenesis and maintenance","Metabolism of RNA",Autophag
y,"DNA Repair","Vesicle-mediated transport","Muscle contraction","Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth fact
or receptors and second messengers","Signaling by TGFB family members","Infectious disease","Signaling by GPCR","Innate Immune System","Platelet homeostasis",Apoptosis,"Transmission across Chemical Sy
napses","RNA Polymerase II Transcription","Cytokine Signaling in Immune system","Nervous system development",Mitotic,"Unfolded Protein Response (UPR)","Metabolism of lipids","Signaling by Hippo","Ion 
channel transport","Signaling by NODAL","Cellular responses to stress","Non-integrin membrane-ECM interactions","Cilium Assembly","rRNA processing","Adaptive Immune System","Cell surface interactions 
at the vascular wall","Signaling by Non-Receptor Tyrosine Kinases","Signaling by Rho GTPases","Disorders of Developmental Biology","MTOR signalling",Macroautophagy,"ECM proteoglycans","DNA Double-Stra
nd Break Repair","Signaling by Hedgehog","Cell Cycle Checkpoints","Metabolism of carbohydrates","MAPK family signaling cascades","Membrane Trafficking","Cardiac conduction","Abacavir transport and met
abolism","PIP3 activates AKT signaling","Signaling by FGFR","Signaling by VEGF","Signaling by FGFR in disease","Signaling by PDGFR in disease","Signaling by Insulin receptor","Signaling by BMP","Leish
mania infection","GPCR downstream signalling","Toll-like Receptor Cascades","Signaling by SCF-KIT","Nitric oxide stimulates guanylate cyclase","Caspase activation via extrinsic apoptotic signalling pa
thway","Neurotransmitter receptors and postsynaptic signal transmission","HIV Infection","Generic Transcription Pathway","Signaling by Interleukins","Interferon Signaling","Axon guidance","Mitotic G1 
phase and G1/S transition","IRE1alpha activates chaperones","Signaling by KIT in disease","Sphingolipid metabolism","Stimuli-sensing channels","Mitotic G2-G2/M phases","Regulation of signaling by NODA
L","Cellular Senescence","Signaling by NTRKs","Phospholipid metabolism","Anchoring of the basal body to the plasma membrane","rRNA processing in the nucleus and cytosol","TCR signaling","Response of E
IF2AK4 (GCN2) to amino acid deficiency","Signaling by PTK6","RHO GTPase Effectors","SARS-CoV Infections","Oncogenic MAPK signaling","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)",
"Disorders of Nervous System Development","mTORC1-mediated signalling","Selective autophagy","Homology Directed Repair","Apoptotic execution phase","Hedgehog 'on' state","M Phase","Fc epsilon receptor
 (FCERI) signaling","Neutrophil degranulation","G2/M Checkpoints","Glycogen metabolism","MAPK1/MAPK3 signaling","Signaling by TGF-beta Receptor Complex in Cancer","Clathrin-mediated endocytosis","Phas
e 3 - rapid repolarisation","Abacavir transmembrane transport","Negative regulation of the PI3K/AKT network","Signaling by FGFR4","VEGFA-VEGFR2 Pathway","Signaling by FGFR1 in disease","VEGF ligand-re
ceptor interactions","Signaling by FGFR3 in disease","Drug resistance of PDGFR mutants","Signaling by FGFR2 in disease","Insulin receptor signalling cascade","Parasite infection","G alpha (i) signalli
ng events","Toll Like Receptor 4 (TLR4) Cascade","cGMP effects","Caspase activation via Dependence Receptors in the absence of ligand","Activation of NMDA receptors and postsynaptic events","HIV Life 
Cycle","Transcriptional Regulation by TP53","Host Interactions of HIV factors","Interleukin-1 family signaling","Interferon alpha/beta signaling","EPH-Ephrin signaling","G1 Phase","Drug resistance of 
KIT mutants","Signaling by ROBO receptors","Semaphorin interactions","RET signaling","Antiviral mechanism by IFN-stimulated genes","Sphingolipid de novo biosynthesis","G2/M Transition","Oxidative Stre
ss Induced Senescence","Signaling by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) Cascade","PI Metabolism","Major pathway of rRNA processing in the nucleolus and cytosol","Interleukin-2 family signaling
","Generation of second messenger molecules","L1CAM interactions","PTK6 promotes HIF1A stabilization","RHO GTPases activate PKNs","PTEN Regulation","SARS-CoV-1 Infection","Signaling by RAS mutants","I
GF1R signaling cascade","Toll Like Receptor 2 (TLR2) Cascade","Transcriptional regulation by RUNX1","Pervasive developmental disorders",Mitophagy,"Leishmania parasite growth and survival","HDR through
 Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Apoptotic cleavage of cellular proteins","RHO GTPases activate PAKs","Mitotic Metaphase and Anaphase","FCERI mediated Ca+2 mobilizati
on","Signaling by NTRK3 (TRKC)","G2/M DNA damage checkpoint","Transcriptional Regulation by VENTX","Glycogen breakdown (glycogenolysis)","RAF/MAP kinase cascade","Loss of Function of SMAD2/3 in Cancer
","Cargo recognition for clathrin-mediated endocytosis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Downstream signaling of activated FGFR4","VEGFR2 mediated cell proliferation","FGFR1 mutant re
ceptor activation","VEGF binds to VEGFR leading to receptor dimerization","Signaling by FGFR3 point mutants in cancer","Imatinib-resistant PDGFR mutants","FGFR2 mutant receptor activation","IRS-mediat
ed signalling","Leishmania phagocytosis","Visual phototransduction","MyD88-independent TLR4 cascade","Post NMDA receptor activation events","Late Phase of HIV Life Cycle","Regulation of TP53 Activity"
,"The role of Nef in HIV-1 replication and disease pathogenesis","Interleukin-1 signaling","Regulation of IFNA signaling","EPHA-mediated growth cone collapse","EPHB-mediated forward signaling","Cyclin
 D associated events in G1","Dasatinib-resistant KIT mutants","Role of ABL in ROBO-SLIT signaling","Sema4D in semaphorin signaling","ISG15 antiviral mechanism","Centrosome maturation","Signalling to E
RKs","MyD88 cascade initiated on plasma membrane","Activation of RAC1","Synthesis of PIPs at the plasma membrane","Interleukin-2 signaling","Recycling pathway of L1","Activated PKN1 stimulates transcr
iption of AR (androgen receptor) regulated genes KLK2 and KLK3","Regulation of PTEN stability and activity","SARS-CoV-1 Genome Replication and Transcription","Signaling downstream of RAS mutants","IRS
-related events triggered by IGF1R","Toll Like Receptor TLR6:TLR2 Cascade","RUNX1 regulates transcription of genes involved in BCR signaling","Loss of function of MECP2 in Rett syndrome","Receptor Med
iated Mitophagy","Anti-inflammatory response favouring Leishmania parasite infection","Activation of TRKA receptors","HDR through Homologous Recombination (HRR)","Interleukin-15 signaling","Mitotic An
aphase","Ephrin signaling","Activated NTRK3 signals through PI3K","Signalling to ERK5","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","CRMPs in Sema3A signaling","SMAD2/3 Phosphoryla
tion Motif Mutants in Cancer","FRS-mediated FGFR4 signaling","Signaling by activated point mutants of FGFR1","FGFR3 mutant receptor activation","Activated point mutants of FGFR2","PI3K Cascade","FCGR3
A-mediated phagocytosis","The phototransduction cascade","TRIF(TICAM1)-mediated TLR4 signaling","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Transcription of the
 HIV genome","Regulation of TP53 Activity through Phosphorylation","Nef and signal transduction","Activation of RAC1 downstream of NMDARs","Regulation of TP53 Expression and Degradation","Sema4D media
ted inhibition of cell attachment and migration","Activation of AMPK downstream of NMDARs","Loss of proteins required for interphase microtubule organization from the centrosome","Signalling to RAS","
MAP kinase activation","Prolonged ERK activation events","Replication of the SARS-CoV-1 genome","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Regulation of TP53 Activity through Acetylation
","Loss of phosphorylation of MECP2 at T308","FCGR3A-mediated IL10 synthesis","NGF-independant TRKA activation","Homologous DNA Pairing and Strand Exchange","Separation of Sister Chromatids","Nef-medi
ates down modulation of cell surface receptors by recruiting them to clathrin adapters","Signaling by activated point mutants of FGFR3",Inactivation,"recovery and regulation of the phototransduction c
ascade","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","RSK activation","HIV Transcription Elongation","Regulation of TP53 Degrad
ation","Ras activation upon Ca2+ influx through NMDA receptor","Loss of Nlp from mitotic centrosomes","p38MAPK events","MAPK targets/ Nuclear events mediated by MAP kinases","Frs2-mediated activation"
,"IKK complex recruitment mediated by RIP1","activated TAK1 mediates p38 MAPK activation","PI5P Regulates TP53 Acetylation","Presynaptic phase of homologous DNA pairing and strand exchange","ARMS-medi
ated activation","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","Nef Mediated CD4 Down-regulation","Tat-mediated elongation of the HIV-1 transcript","CREB phosp
horylation","Activation of the AP-1 family of transcription factors","ERK/MAPK targets","Formation of HIV-1 elongation complex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
{FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,KDR,PDGFRA,PDGFRB}

> <broad_moa>
{"FGFR inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{BIBF1120(Vargatef),"Nintedanib (BIBF 1120)",BIBF-1120,S1010}

> <pdid>
PD003643

> <targets>
{VEGFR,FGFR,PDGFR,"FGFR | VEGFR-PDGFR"}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{56965894}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 O   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -3.8939    0.7546    0.0000 C   0  0
   -5.1904    1.5090    0.0000 C   0  0
   -6.4920    0.7635    0.0000 C   0  0
   -7.7907    1.5158    0.0000 N   0  0
   -9.0920    0.7680    0.0000 C   0  0
   -9.0945   -0.7320    0.0000 O   0  0
  -10.3907    1.5202    0.0000 C   0  0
  -10.3856    3.0203    0.0000 C   0  0
  -11.6821    3.7747    0.0000 N   0  0
  -12.9837    3.0292    0.0000 C   0  0
  -12.9888    1.5292    0.0000 C   0  0
  -11.6923    0.7747    0.0000 C   0  0
  -11.6975   -0.7253    0.0000 O   0  0
  -14.2910    0.7832    0.0000 C   0  0
  -15.5888    1.5356    0.0000 C   0  0
  -16.8892    0.7880    0.0000 C   0  0
  -16.8920   -0.7120    0.0000 C   0  0
  -18.1924   -1.4596    0.0000 F   0  0
  -15.5943   -1.4644    0.0000 C   0  0
  -14.2939   -0.7168    0.0000 C   0  0
   -6.4971   -0.7365    0.0000 C   0  0
   -5.2007   -1.4909    0.0000 C   0  0
   -5.2059   -2.9909    0.0000 F   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 15  1  0
 20 21  2  0
 19 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 22  1  0
 11 29  1  0
 29 30  2  0
 30  8  1  0
 30 31  1  0
  6 32  2  0
 32  2  1  0
 32 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28417

> <plate>
Kinase v5-2

> <well>
C07

> <supplier_cmpd_name>
BMS 794833

> <ctcr_id>
6040

> <supplier_cmpd_id>
S2201

> <smiles>
Nc1nccc(Oc2ccc(NC(=O)C3=CNC=C(C3=O)c4ccc(F)cc4)cc2F)c1Cl

> <pd_targets>
{KDR,MET}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type X RTKs: HGF
 (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Signaling by Receptor Tyrosine Kinases","Nervous system development","Signaling by VEGF","Axon guidance","VEGFA-VEGFR2 Pathway","Semaphorin interactions
","VEGFR2 mediated cell proliferation","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{ABL1,BCR}

> <broad_moa>
{"Bcr-Abl kinase inhibitor"}

> <synonyms>
{MS79483,BMS-794833,BMS794833,1174046-72-0,1174046720,"BMS 794833",CHEMBL2143592,metatinib,cc-603,cc603,MLS006010952,C23H15ClF2N4O3,SCHEMBL700499,SCHEMBL13770016,DTXSID30657662,EX-A550,EXA550,BCPP0003
23,HMS3655B10,BDBM50146164,MFCD18206786,ZINC43206812,AKOS026750476,BCP9000437,T2419,S2201}

> <pdid>
PD010829

> <targets>
{VEGFR-PDGFR,VEGFR,c-Met}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{44155856}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 O   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0897    3.7657    0.0000 N   0  0
  -10.3910    3.0180    0.0000 C   0  0
  -10.3936    1.5180    0.0000 O   0  0
  -11.6897    3.7702    0.0000 N   0  0
  -12.9910    3.0224    0.0000 C   0  0
  -14.3424    3.6434    0.0000 C   0  0
  -15.3461    2.5287    0.0000 C   0  0
  -16.8378    2.6854    0.0000 C   0  0
  -14.5960    1.2296    0.0000 O   0  0
  -13.1288    1.5415    0.0000 N   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Cl  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  1  0
 24 19  2  0
 14 25  1  0
 25 26  1  0
 25 27  2  0
 27 11  1  0
  9 28  2  0
 28  5  1  0
 28 29  1  0
 29 30  2  0
 30  3  1  0
 30 31  1  0
 31 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28418

> <plate>
Kinase v5-2

> <well>
C09

> <supplier_cmpd_name>
AV-951(Tivozanib)

> <ctcr_id>
2567

> <supplier_cmpd_id>
S1207

> <smiles>
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC

> <pd_targets>
{FLT4,EPHB2,PDGFRA,FLT1,KDR,FGF2,EGFR,PDGFRB}

> <pathway_gtopdb>
{Enzyme,"Secreted protein",Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Eph family","Tyrosine protein kinase PDGFR family","Tyrosin
e protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XIII RTKs: 
Ephrin receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology",Disease,"Signaling by Receptor Tyrosine Kinases","Nervous system development","Diseases of signal transduction by growth factor receptors and second mess
engers","Signaling by GPCR","Intracellular signaling by second messengers","Signaling by VEGF","Axon guidance","Signaling by PDGFR in disease","Signaling by FGFR in disease","GPCR downstream signallin
g","PIP3 activates AKT signaling","VEGF ligand-receptor interactions","EPH-Ephrin signaling","Drug resistance of PDGFR mutants","VEGFA-VEGFR2 Pathway","Signaling by FGFR3 in disease","G alpha (q) sign
alling events","Negative regulation of the PI3K/AKT network","VEGF binds to VEGFR leading to receptor dimerization","EPHB-mediated forward signaling","Imatinib-resistant PDGFR mutants","VEGFR2 mediate
d cell proliferation","Signaling by FGFR3 point mutants in cancer","Gastrin-CREB signalling pathway via PKC and MAPK",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","FGFR3 mutant receptor activation
","EGFR Transactivation by Gastrin","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
{FLT1,FLT4,KDR,KIT,PDGFRA,PDGFRB}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{"IVOZANIB (AV951","IVOZANIB (AV 951",Tivozanib,475108-18-0,475108180,"475108 18 0",AV-951,AV951,"AV 951","Tivozanib (AV-951)","Tivozanib (AV951)","Tivozanib (AV 951)",KRN-951,KRN951,"KRN 951",UNII-17
2030934T,UNII172030934T,"UNII 172030934T",CHEMBL1289494,AV-951;KRN951,AV951;KRN951,"AV 951;KRN951",AV-951(Tivozanib),AV951(Tivozanib),"AV 951(Tivozanib)",172030934T,fotivda,Kil-8951,Kil8951,"Kil 8951"
,ASP-4130,ASP4130,"ASP 4130","Tivozanib (USAN:INN)",4ase,KIL8951,T,T2456,S1207,"EMD 676483",tivozanib,676483}

> <pdid>
PD003428

> <targets>
{VEGFR-PDGFR,PDGFR,VEGFR,c-Kit}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{9911830}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2982    3.7531    0.0000 O   0  0
    1.2960    5.2539    0.0000 C   0  0
   -0.0056    5.9995    0.0000 C   0  0
   -0.0108    7.4995    0.0000 C   0  0
    1.2856    8.2540    0.0000 C   0  0
    1.5920    9.7216    0.0000 N   0  0
    3.0832    9.8835    0.0000 C   0  0
    3.8287   11.1851    0.0000 C   0  0
    3.6981    8.5153    0.0000 C   0  0
    2.5873    7.5085    0.0000 C   0  0
    2.5924    6.0085    0.0000 C   0  0
    3.8941    5.2631    0.0000 F   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 N   0  0
   -3.8244   -8.3594    0.0000 C   0  0
   -3.3609   -9.7860    0.0000 C   0  0
   -1.8609   -9.7860    0.0000 C   0  0
   -1.3973   -8.3594    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 17  8  1  0
 17 18  1  0
  6 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22  5  1  0
 22 23  1  0
 23 24  2  0
 24  3  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28419

> <plate>
Kinase v5-2

> <well>
C11

> <supplier_cmpd_name>
Cediranib(AZD2171)

> <ctcr_id>
625

> <supplier_cmpd_id>
S1017

> <smiles>
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN5CCCC5

> <pd_targets>
{KDR,BTK,MET,EGFR,GAK,SRC,PRKD2,STK26,DDR1,HCK,MAP4K1,MERTK,MAP4K3,ERBB2,ERN1,CSNK1E,ABL1,PDGFRB,MAP3K19,MAP4K4,DDR2,EPHA3,YES1,PTK6,PLK4,TYRO3,FGFR1,RIPK2,MAP4K2,KIT,FER,PDGFRA,SLK,BLK,ERBB4,AURKB,CS
F1R,EPHA1,LCK,TIE1,SIK2,MAPK14,LTK,TAOK3,FRK,RET,MAP2K2,MAP2K5,FGFR2,STK35,ACVR1B,AXL,EIF2AK1,FLT1,LYN,FYN,FGR,TGFBR1,FGFR3,FLT3,FLT4,MAP4K5,EPHA6,ACVR1,CHEK2,MINK1,MST1R,ABL2,EPHA8,TEK,CAMK2B,ALK,EPH
B4,EPHB6,AURKC,TNIK,TAOK2,EPHA7,STK33,FGFR4,STK3,STK4,ERBB3,SYK,STK10,TAOK1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,Transferase,"Protein Kinase","TK protein kinase group","Other protein kinase group","CAMK protein kinase group","STE protein kinase group","CK1 protein kinase gro
up","TKL protein kinase group","CMGC protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Met family","Tyrosine protein kinase EGF
R family","Other protein kinase NAK family","Tyrosine protein kinase Src family","CAMK protein kinase PKD family","STE protein kinase STE20 family","Tyrosine protein kinase DDR family","Tyrosine prote
in kinase Axl family","CK1 protein kinase CK1 family","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR family","STE protein kinase STE11 family","Tyrosine protein kinase Eph family"
,"Other protein kinase PLK family","Tyrosine protein kinase FGFR family","TKL protein kinase RIPK family","Tyrosine protein kinase Fer family","Other protein kinase AUR family","Tyrosine protein kinas
e Tie family","CAMK protein kinase CAMK1 family","CMGC protein kinase MAPK family","Tyrosine protein kinase Alk family","Tyrosine protein kinase Ret family","STE protein kinase STE7 family","Other pro
tein kinase NKF4 family","TKL protein kinase STKR family","Other protein kinase PEK family","CAMK protein kinase RAD53 family","CAMK protein kinase CAMK2 family","CAMK protein kinase unique family","T
yrosine protein kinase Syk family","STE protein kinase YSK subfamily","STE protein kinase KHS subfamily","STE protein kinase MSN subfamily","STE protein kinase SLK subfamily","CAMK protein kinase QIK 
subfamily","CMGC protein kinase p38 subfamily","STE protein kinase TAO subfamily","TKL protein kinase STKR Type 1 subfamily","Other protein kinase HRI","Tyrosine protein kinase SrcA","TKL protein kina
se STKR1","STE protein kinase MST subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kina
ses","CK1: Casein kinase 1","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Other protein kinases","Protein kinase D (PKD) family","STE20 family","Casein kinase 1 (CK1) family",
"TKL: Tyrosine kinase-like","CAMK-like (CAMKL) family","Mitogen-activated protein kinases (MAP kinases)","STE7 family","CAMK2 family","CAMK-unique family","Receptor tyrosine kinases (RTKs)","Non-recep
tor tyrosine kinases (nRTKs)","Numb-associated kinase (NAK) family","YSK subfamily","KHS subfamily","IRE family","STE20 subfamily","MSN subfamily","Polo-like kinase (PLK) family","Receptor interacting
 protein kinase (RIPK) family","SLK subfamily","Aurora kinase (Aur) family","QIK subfamily","p38 subfamily","TAO subfamily","NKF4 family","Receptor serine/threonine kinase (RSTK) family","PEK family",
"CHK1 subfamily","MST subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Tec family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type I RTKs: ErbB
 (epidermal growth factor) receptor family","Src family","Type XVI RTKs: DDR (collagen receptor) family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Abl family","Type III RTKs: PDG
FR",CSFR,Kit,"FLT3 receptor family","Type XIII RTKs: Ephrin receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Fer family","Type XII RTKs: TIE family of angiopoietin recep
tors","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XIV RTKs: RET","Type I receptor serine/threonine kinases","Other PEK family kinases","Syk family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Developmental Biology","Vesicle-mediated transport",Metabolism,"Programmed Cell Death","Extracellular matrix organization",Hemostasis,"Metabolism of proteins","Cell Cyc
le","Cellular responses to external stimuli","Immune System","Gene expression (Transcription)","Neuronal System","Signaling by Receptor Tyrosine Kinases","Infectious disease","Nervous system developme
nt","Signaling by GPCR","Membrane Trafficking","Metabolism of lipids",Apoptosis,"Non-integrin membrane-ECM interactions","Cell surface interactions at the vascular wall","Unfolded Protein Response (UP
R)",Mitotic,"Intracellular signaling by second messengers","Cellular responses to stress","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System","RNA
 Polymerase II Transcription","Transmission across Chemical Synapses","Signaling by NODAL","MAPK family signaling cascades","Signaling by Hippo","Signaling by VEGF","Leishmania infection","Axon guidan
ce","GPCR downstream signalling","trans-Golgi Network Vesicle Budding","Signaling by NTRKs","Sphingolipid metabolism","Apoptotic execution phase","HIV Infection","IRE1alpha activates chaperones","Mito
tic G2-G2/M phases","PIP3 activates AKT signaling","Cellular Senescence","Mitotic G1 phase and G1/S transition","Signaling by FGFR in disease","Toll-like Receptor Cascades","Signaling by KIT in diseas
e","Signaling by SCF-KIT","Signaling by PDGFR in disease","Generic Transcription Pathway","Neurotransmitter receptors and postsynaptic signal transmission","M Phase","Regulation of signaling by NODAL"
,"Response of EIF2AK1 (HRI) to heme deficiency","Signaling by TGF-beta Receptor Complex in Cancer","Signaling by Insulin receptor","Signaling by MST1","MAPK1/MAPK3 signaling","Signaling by FGFR","Neut
rophil degranulation","VEGFA-VEGFR2 Pathway","Parasite infection","Semaphorin interactions","G alpha (q) signalling events","Golgi Associated Vesicle Biogenesis","Signaling by NTRK1 (TRKA)","Sphingoli
pid de novo biosynthesis","Apoptotic cleavage of cellular proteins","Host Interactions of HIV factors","G2/M Transition","Negative regulation of the PI3K/AKT network","Oxidative Stress Induced Senesce
nce","EPH-Ephrin signaling","Leishmania parasite growth and survival","G1 Phase","Signaling by FGFR1 in disease","Toll Like Receptor 5 (TLR5) Cascade","Drug resistance of KIT mutants","Drug resistance
 of PDGFR mutants","Transcriptional regulation by RUNX1","Activation of NMDA receptors and postsynaptic events","Mitotic Metaphase and Anaphase","Transcriptional Regulation by VENTX","PTEN Regulation"
,"RET signaling","Signaling by FGFR2 in disease","VEGF ligand-receptor interactions","Loss of Function of SMAD2/3 in Cancer","Signaling by FGFR3 in disease","Insulin receptor signalling cascade","Tran
scriptional Regulation by TP53","Signaling by ROBO receptors","RAF/MAP kinase cascade","Signaling by FGFR4","VEGFR2 mediated cell proliferation","Leishmania phagocytosis","Sema4D in semaphorin signali
ng","Gastrin-CREB signalling pathway via PKC and MAPK","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis","Centrosome maturation",PI5P,"PP2A and IER3 Regulate PI3K/AK
T Signaling","EPHA-mediated growth cone collapse","Anti-inflammatory response favouring Leishmania parasite infection","Cyclin D associated events in G1","FGFR1 mutant receptor activation","MyD88 casc
ade initiated on plasma membrane","Dasatinib-resistant KIT mutants","Imatinib-resistant PDGFR mutants","RUNX1 regulates transcription of genes involved in BCR signaling","Post NMDA receptor activation
 events","Mitotic Anaphase","Regulation of PTEN stability and activity","Signalling to ERK5","FGFR2 mutant receptor activation","VEGF binds to VEGFR leading to receptor dimerization","SMAD2/3 Phosphor
ylation Motif Mutants in Cancer","Signaling by FGFR3 point mutants in cancer","IRS-mediated signalling","Regulation of TP53 Activity","Role of ABL in ROBO-SLIT signaling","EPHB-mediated forward signal
ing","Downstream signaling of activated FGFR4","FCGR3A-mediated phagocytosis","Sema4D mediated inhibition of cell attachment and migration","EGFR Transactivation by Gastrin","Signalling to RAS","Nef a
nd signal transduction","Sema4D induced cell migration and growth-cone collapse","Loss of proteins required for interphase microtubule organization from the centrosome","FCGR3A-mediated IL10 synthesis
","Signaling by activated point mutants of FGFR1","MAP kinase activation","Long-term potentiation","Separation of Sister Chromatids","Nef-mediates down modulation of cell surface receptors by recruiti
ng them to clathrin adapters","Prolonged ERK activation events","Activated point mutants of FGFR2","FGFR3 mutant receptor activation","PI3K Cascade","Regulation of TP53 Expression and Degradation","CR
EB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","FRS-mediated FGFR4 signaling","p38MAPK events","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK
 activation","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","Frs2-mediated activation","Signaling by activated point mutants of FGFR3","Regulation of TP53 De
gradation","Ras activation upon Ca2+ influx through NMDA receptor","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{CSF1R,FLT1,FLT3,FLT4,KDR,KIT,PDGFRA,PDGFRB}

> <broad_moa>
{"KIT inhibitor","VEGFR inhibitor"}

> <synonyms>
{Cediranib,288383-20-0,288383200,"288383 20 0",Recentin,AZD2171,Cedirannib,"Cediranib (AZD2171)","AZD 2171",AZD-2171,"Cediranib (AZD217)",UNII-NQU9IPY4K9,UNIINQU9IPY4K9,"UNII NQU9IPY4K9","Cediranib fr
ee base",NQU9IPY4K9,ZD-2171,ZD2171,"ZD 2171","AZD-2171 maleate","AZD2171 maleate","AZD 2171 maleate",CHEMBL491473,"288383-20-0 (free base)","288383200 (free base)","288383 20 0 (free base)",NSC-732208
,NSC732208,"NSC 732208",C25H27,T2500,S1017,cediranib,Cediranib(AZD2171),CEDIRANIB}

> <pdid>
PD003639

> <targets>
{VEGFR-PDGFR,"VEGFR Inhibitors"}

> <classes>
{}

> <pubchem_cids>
{9933475}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 O   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0897    3.7657    0.0000 N   0  0
  -10.3910    3.0180    0.0000 C   0  0
  -10.3936    1.5180    0.0000 O   0  0
  -11.6897    3.7702    0.0000 N   0  0
  -12.9910    3.0224    0.0000 C   0  0
  -12.9910    1.5223    0.0000 C   0  0
  -14.2901    0.7723    0.0000 C   0  0
  -15.5891    1.5223    0.0000 C   0  0
  -16.8882    0.7723    0.0000 F   0  0
  -15.5891    3.0223    0.0000 C   0  0
  -14.2901    3.7723    0.0000 C   0  0
  -14.2901    5.2723    0.0000 F   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 F   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
 25 26  1  0
 14 27  1  0
 27 28  1  0
 27 29  2  0
 29 11  1  0
  9 30  2  0
 30  5  1  0
 30 31  1  0
 31 32  2  0
 32  3  1  0
 32 33  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28420

> <plate>
Kinase v5-2

> <well>
C13

> <supplier_cmpd_name>
Ki8751

> <ctcr_id>
4784

> <supplier_cmpd_id>
S1363

> <smiles>
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC

> <pd_targets>
{KDR,FGFR2,KIT,PDGFRA,RORC}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,"Nuclear receptor","Protein Kinase","Nuclear hormone receptor subfamily 1","TK protein kinase group","Nuclear hormone receptor subfamily 1 group F","Tyrosine prot
ein kinase VEGFR family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Nuclear hormone receptors","Receptor kinases","1F. Retinoic acid-related orphans","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascul
ar endothelial growth factor) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polyme
rase II Transcription","Signaling by VEGF","Signaling by FGFR in disease","Signaling by KIT in disease","Signaling by PDGFR in disease","Generic Transcription Pathway","VEGFA-VEGFR2 Pathway","Signalin
g by FGFR2 in disease","Drug resistance of KIT mutants","Drug resistance of PDGFR mutants","Transcriptional regulation by RUNX3","VEGFR2 mediated cell proliferation","FGFR2 mutant receptor activation"
,"Dasatinib-resistant KIT mutants","Imatinib-resistant PDGFR mutants","RUNX3 Regulates Immune Response and Cell Migration","Activated point mutants of FGFR2"}

> <broad_targets>
{KDR}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{Ki8751,228559-41-9,228559419,"Ki 8751",Ki-8751,CHEMBL178455,C24H18F3N3O4,cc-604,cc604,MLS006011284,SCHEMBL1249562,CHEBI:92822,TERT-BUTYL2-BROMOBUTYRATE,TERTBUTYL2BROMOBUTYRATE,AOB6619,DTXSID60462145,
EX-A227,EXA227,HMS3269O17,HMS3413F19,HMS3654B19,HMS3677F19,BCP02842,ZINC1490414,ABP001020,BDB,T2446,S1363,2542,KI8751}

> <pdid>
PD003649

> <targets>
{"c-Kit | VEGFR-PDGFR",PDGFR,VEGFR,c-Kit}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{11317348}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    4.2566    0.5871    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.8089   -4.6669    0.0000 N   0  0
    2.7343   -2.9815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
   -2.5795   -7.5047    0.0000 N   0  0
   -3.8747   -8.2614    0.0000 C   0  0
   -3.8672   -9.7614    0.0000 C   0  0
   -2.5644  -10.5048    0.0000 O   0  0
   -1.2691   -9.7483    0.0000 C   0  0
   -1.2767   -8.2483    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  7  2  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
 12 26  2  0
 26  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28421

> <plate>
Kinase v5-2

> <well>
C15

> <supplier_cmpd_name>
CYC116

> <ctcr_id>
3852

> <supplier_cmpd_id>
S1171

> <smiles>
Cc1nc(N)sc1c2ccnc(Nc3ccc(cc3)N4CCOCC4)n2

> <pd_targets>
{IKBKE,SYK,CDK9,PRKAA1,MAP3K20,IRAK4,TYK2,IRAK1,CSNK1A1,PRKACA,JAK2,FRK,DYRK1A,CHEK1,MAPK9,PAK4,JAK3,FER,AURKB,RPS6KB1,KDR,CCND1,FLT3,CDK2,CSF1R,STK3,CDK5,DAPK3,NEK4,PRKD3,WEE1,HIPK2,MET,FLT1,MAP4K5,T
BK1,PLK4,NTRK3,MAP4K4,CLK2,KIT,SGK2,TAOK1,BLK,MAP4K2,PKN2,MAPK12,CLK4,AURKA,LCK,GSK3B,CCNE1,GSK3A,CAMK2A,CDK4,BRSK1,PHKG2,CSNK1G1,STK17A,CSNK2A1,FGFR1,CHEK2,CDC7,MKNK2,FYN,SRC,RPS6KA3,MARK3,LYN,TNK2,C
SNK1D,MAPK8,PDGFRA,ROCK2,ROCK1,NEK2,ABL1,LTK,EGFR,ITK,EPHA2,CAMK2D,HIPK4,PDPK1,AURKC,AKT1,CDK1,CSNK1G2,RET,PRKD2,ROS1,INSR,CAMK2B,SLK,FGFR3,CCNT1,CAMK2G}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein",Kinase,"Protein Kinase","Other protein kinase group","TK protein kinase group","CMGC protein kinase group","CAMK protein kinase group","TKL protein kinase group","CK1
 protein kinase group","AGC protein kinase group","STE protein kinase group","Tyrosine protein kinase Syk family","CMGC protein kinase CDK family","CAMK protein kinase CAMK1 family","TKL protein kinas
e MLK family","TKL protein kinase IRAK family","Tyrosine protein kinase JakA family","CK1 protein kinase CK1 family","AGC protein kinase PKA family","Tyrosine protein kinase Src family","CMGC protein 
kinase DYRK family","CMGC protein kinase MAPK family","STE protein kinase STE20 family","Tyrosine protein kinase Fer family","Other protein kinase AUR family","AGC protein kinase RSK family","Tyrosine
 protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","CAMK protein kinase DAPK family","Other protein kinase NEK family","CAMK protein kinase PKD family","Other protein kinase WEE fami
ly","Tyrosine protein kinase Met family","Other protein kinase IKK family","Other protein kinase PLK family","Tyrosine protein kinase Trk family","CMGC protein kinase CLK family","AGC protein kinase S
GK family","AGC protein kinase PKN family","CMGC protein kinase GSK family","CAMK protein kinase CAMK2 family","CAMK protein kinase PHk family","Other protein kinase CK2 family","Tyrosine protein kina
se FGFR family","CAMK protein kinase RAD53 family","Other protein kinase CDC7 family","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Ack family","AGC protein kinase DMPK family","Tyrosi
ne protein kinase Abl family","Tyrosine protein kinase Alk family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Eph family","AGC protein kinase P
DK1 subfamily","AGC protein kinase AKT family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Sev family","Tyrosine protein kinase InsR family","CMGC protein kinase CDK9 subfamily","CAM
K protein kinase AMPK subfamily","TKL protein kinase MLK subfamily","CMGC protein kinase Dyrk1 subfamily","CAMK protein kinase CHK1 subfamily","CMGC protein kinase JNK subfamily","STE protein kinase P
AKB subfamily","AGC protein kinase p70 subfamily","CMGC protein kinase CDC2 subfamily","STE protein kinase MST subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase HIPK subfamily","STE
 protein kinase KHS subfamily","STE protein kinase MSN subfamily","STE protein kinase TAO subfamily","CMGC protein kinase p38 subfamily","CAMK protein kinase BRSK subfamily","CAMK protein kinase MNK s
ubfamily","Tyrosine protein kinase SrcA","AGC protein kinase RSK subfamily","CAMK protein kinase MARK subfamily","AGC protein kinase ROCK subfamily","STE protein kinase SLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","CK1: Casein kin
ase 1","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Other protein kinases","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family
","CAMK-like (CAMKL) family","TKL: Tyrosine kinase-like","Casein kinase 1 (CK1) family","Protein kinase A (PKA) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","
Mitogen-activated protein kinases (MAP kinases)","STE20 family","RSK family","Death-associated kinase (DAPK) family","Protein kinase D (PKD) family","CLK family","SGK family","Protein kinase N (PKN) f
amily","Glycogen synthase kinase (GSK) family","CAMK2 family","Phosphorylase kinase (PHK) family","MAPK-Activated Protein Kinase (MAPKAPK) family","DMPK family","PDK1 family","Akt (Protein kinase B","
PKB) family","IKK family","Non-receptor tyrosine kinases (nRTKs)","CDK9 subfamily","AMPK subfamily","Mixed Lineage Kinase (MLK) family","Interleukin-1 receptor-associated kinase (IRAK) family","Dyrk1 
subfamily","CHK1 subfamily","JNK subfamily","PAKB subfamily","Aurora kinase (Aur) family","p70 subfamily","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","MST subfamily","CDK5 subfamily","NIMA (ne
ver in mitosis gene a)- related kinase (NEK) family","WEE family","HIPK subfamily","KHS subfamily","Polo-like kinase (PLK) family","MSN subfamily","TAO subfamily","p38 subfamily","GSK subfamily","CDK4
 subfamily","BRSK subfamily","Casein kinase 2 (CK2) family","CDC7 family","MKN subfamily","RSK subfamily","MARK subfamily","Rho kinase","SLK subfamily","Syk family","MLK subfamily","Janus kinase (JakA
) family","Src family","Fer family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type X RTKs: HGF (hepatocyte growt
h factor) receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Ack family","Abl family","Type XIX RTKs: Leukocyte tyrosine 
kinase (LTK) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Tec family","Type XIII RTKs: Ephrin receptor family","Type XIV RTKs: RET","Type XVII RTKs: ROS receptors","
Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Immune System",Disease,"Gene expression (Transcription)","Cell Cycle","Signal Transduction","DNA Repair","Developmental Biology","Programmed Cell Death",Metabolism,"Cellular responses to external st
imuli","Transport of small molecules","Neuronal System","Innate Immune System","Infectious disease","RNA Polymerase II Transcription","Cytokine Signaling in Immune system","Diseases of signal transduc
tion by growth factor receptors and second messengers",Mitotic,"Intracellular signaling by second messengers","DNA Double-Strand Break Repair","Nervous system development","Signaling by Receptor Tyros
ine Kinases","MTOR signalling","Signaling by Hippo",Apoptosis,"Metabolism of lipids","Cell Cycle Checkpoints","Cellular responses to stress","Ion channel transport","Signaling by Rho GTPases","Transmi
ssion across Chemical Synapses","Metabolism of carbohydrates","Signaling by GPCR","Adaptive Immune System","Toll-like Receptor Cascades","Leishmania infection","HIV Infection","Generic Transcription P
athway","Interferon Signaling","Signaling by WNT in cancer","Mitotic G2-G2/M phases","Mitotic G1 phase and G1/S transition","PIP3 activates AKT signaling","Homology Directed Repair","Axon guidance","S
ignaling by Interleukins","Signaling by SCF-KIT","M Phase","mTORC1-mediated signalling","Signaling by VEGF","Signaling by Insulin receptor","Caspase activation via extrinsic apoptotic signalling pathw
ay","Sphingolipid metabolism","G2/M Checkpoints","Signaling by NTRKs","Cellular Senescence","Signaling by KIT in disease","Stimuli-sensing channels","RHO GTPase Effectors","SARS-CoV Infections","Neuro
transmitter receptors and postsynaptic signal transmission","Glycogen metabolism","Signaling by FGFR in disease","Oncogenic MAPK signaling","Signaling by PDGFR in disease","Regulation of mitotic cell 
cycle","GPCR downstream signalling","TCR signaling","Toll Like Receptor 4 (TLR4) Cascade","Leishmania parasite growth and survival","HIV Life Cycle","Transcriptional Regulation by TP53","Toll Like Rec
eptor 2 (TLR2) Cascade","Interferon alpha/beta signaling","Toll Like Receptor 5 (TLR5) Cascade","Signaling by AMER1 mutants","G2/M Transition","G1 Phase","PTEN Regulation","G0 and Early G1","HDR throu
gh Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Signaling by ROBO receptors","Interleukin-2 family signaling","Mitotic Metaphase and Anaphase","VEGFA-VEGFR2 Pathway","Insulin rece
ptor signalling cascade","Transcriptional Regulation by VENTX","Caspase activation via Dependence Receptors in the absence of ligand","Sphingolipid de novo biosynthesis","G2/M DNA damage checkpoint","
Semaphorin interactions","VEGF ligand-receptor interactions","Signaling by NTRK3 (TRKC)","Oxidative Stress Induced Senescence","Drug resistance of KIT mutants","Transcriptional regulation by RUNX1","R
HO GTPases activate PKNs","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","SARS-CoV-1 Infection","Activation of NMDA receptors and postsynaptic events","Glycogen breakdown (glycogenolys
is)","Signaling by FGFR1 in disease","G1/S Transition","Signaling by RAS mutants","Drug resistance of PDGFR mutants","APC/C-mediated degradation of cell cycle proteins","Parasite infection","G alpha (
q) signalling events","Generation of second messenger molecules","EPH-Ephrin signaling","RET signaling","Negative regulation of the PI3K/AKT network","Signaling by FGFR3 in disease","MyD88-independent
 TLR4 cascade","Anti-inflammatory response favouring Leishmania parasite infection","Late Phase of HIV Life Cycle","Regulation of TP53 Activity","Toll Like Receptor TLR6:TLR2 Cascade","Regulation of I
FNA signaling","MyD88 cascade initiated on plasma membrane","Truncations of AMER1 destabilize the destruction complex","Centrosome maturation","Cyclin D associated events in G1","Regulation of PTEN st
ability and activity","HDR through Homologous Recombination (HRR)","Activation of RAC1","Interleukin-15 signaling","Mitotic Anaphase","VEGFR2 mediated cell proliferation","IRS-mediated signalling","Ch
k1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Sema4D in semaphorin signaling","VEGF binds to VEGFR leading to receptor dimerization","Activated NTRK3 signals through PI3K","Dasatinib-
resistant KIT mutants","RUNX1 regulates transcription of genes involved in BCR signaling","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis","SARS-CoV-1 Genome Replic
ation and Transcription","Post NMDA receptor activation events","FGFR1 mutant receptor activation","Activation of the pre-replicative complex","Signaling downstream of RAS mutants","Imatinib-resistant
 PDGFR mutants","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Leishmania phagocytosis","Gastrin-CREB signalling pathway via PKC and MAPK","EPHA-mediated growth cone c
ollapse","Cyclin E associated events during G1/S transition",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signaling by FGFR3 point mutants in cancer","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3
A-mediated IL10 synthesis","Transcription of the HIV genome","Regulation of TP53 Activity through Phosphorylation","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","MAP kinase activation","Loss
 of proteins required for interphase microtubule organization from the centrosome","Homologous DNA Pairing and Strand Exchange","Separation of Sister Chromatids","PI3K Cascade","Regulation of TP53 Exp
ression and Degradation","Sema4D mediated inhibition of cell attachment and migration","Signalling to RAS","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapte
rs","Replication of the SARS-CoV-1 genome","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Signaling by activated point mutants of FGFR1","Nef and signal transducti
on","Sema4D induced cell migration and growth-cone collapse","APC/C:Cdc20 mediated degradation of mitotic proteins","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Phosphorylation of
 proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes","FGFR3 mutant receptor activation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","HIV Transcription Elongation","activ
ated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","Presynaptic phase of homologous DNA pairing and strand exchange","MAPK targets/ Nuclear events mediated by MAP kinases",
"Regulation of TP53 Degradation","p38MAPK events","Nef Mediated CD4 Down-regulation","Ras activation upon Ca2+ influx through NMDA receptor","APC:Cdc20 mediated degradation of cell cycle proteins prio
r to satisfation of the cell cycle checkpoint","Signaling by activated point mutants of FGFR3","Tat-mediated elongation of the HIV-1 transcript","Activation of the AP-1 family of transcription factors
","CREB phosphorylation","APC-Cdc20 mediated degradation of Nek2A","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{AURKA,AURKB,KDR}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{693228-63-6,693228636,CYC-116,CYC116,CHEMBL482967,"CYC 116",4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine,4methyl5(2(4morpholinophenylamino)pyrimidin4yl)thiazol2amine,4-Methyl
-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine,4Methyl5(2((4morpholinophenyl)amino)pyrimidin4yl)thiazol2amine,4-methyl-5-(2-(4-morpholin-4-ylanilino)pyrimidin-4-yl),4methyl5(2(4morph
olin4ylanilino)pyrimidin4yl),T6458,S1171}

> <pdid>
PD011106

> <targets>
{"Aurora | VEGFR-PDGFR","Aurora Kinase",VEGFR}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{6420138}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 O   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0897    3.7657    0.0000 N   0  0
  -10.3910    3.0180    0.0000 C   0  0
  -10.3936    1.5180    0.0000 O   0  0
  -11.6897    3.7702    0.0000 N   0  0
  -12.9910    3.0224    0.0000 C   0  0
  -14.4118    3.0680    0.0000 C   0  0
  -13.6617    1.7690    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Cl  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
    1.2947   -3.7531    0.0000 N   0  0
   -1.3032   -3.7490    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 19  1  0
 14 22  1  0
 22 23  1  0
 22 24  2  0
 24 11  1  0
  9 25  2  0
 25  5  1  0
 25 26  1  0
 26 27  2  0
 27  3  1  0
 27 28  1  0
 28 29  1  0
 28 30  2  0
M  END
> <name>
UTKinase_V5

> <id>
28422

> <plate>
Kinase v5-2

> <well>
C17

> <supplier_cmpd_name>
E7080

> <ctcr_id>
5913

> <supplier_cmpd_id>
S1164

> <smiles>
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O

> <pd_targets>
{KDR,FLT1,FLT4,NCOA4,RET,CA5A,KIF5B,CCDC6,FGFR1,FGFR2,FGFR3,FGFR4,PDGFRA,KIT}

> <pathway_gtopdb>
{Enzyme,Kinase,Lyase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase FGFR family","Tyrosine protein kina
se PDGFR family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Carbonic anhydrases","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) rece
ptor family","Type XIV RTKs: RET","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,"Developmental Biology",Disease,"Signaling by Receptor Tyrosine Kinases","Reversible hydration of carbon dioxide","Nervous system development","Diseases of signal tra
nsduction by growth factor receptors and second messengers","Signaling by VEGF","Axon guidance","Signaling by FGFR in disease","Signaling by FGFR","Signaling by PDGFR in disease","Signaling by KIT in 
disease","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","RET signaling","Signaling by FGFR1 in disease","Signaling by FGFR2 in disease","Signaling by FGFR3 in disease","Signaling by FGFR4"
,"Drug resistance of PDGFR mutants","Drug resistance of KIT mutants","VEGFR2 mediated cell proliferation","VEGF binds to VEGFR leading to receptor dimerization","FGFR1 mutant receptor activation","FGF
R2 mutant receptor activation","Signaling by FGFR3 point mutants in cancer","Downstream signaling of activated FGFR4","Imatinib-resistant PDGFR mutants","Dasatinib-resistant KIT mutants","Signaling by
 activated point mutants of FGFR1","Activated point mutants of FGFR2","FGFR3 mutant receptor activation","FRS-mediated FGFR4 signaling","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
{FLT4,KDR}

> <broad_moa>
{"FGFR inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{Lenvatinib,417716-92-8,417716928,E7080,"Lenvatinib (E7080)",Lenvima,"E7080 (Lenvatinib)","E 7080",E-7080,ER-203492-00,ER20349200,UNII-EE083865G2,UNIIEE083865G2,"Lenvatinib free base",CHEMBL1289601,CH
EBI:85994,"417716-92-8 (free base)","417716928 (free base)",EE083865G2,"Lenvatinib (USAN:INN)",Kisplyx,LEV,Len,T0520,755980,S1164,lenvatinib}

> <pdid>
PD003669

> <targets>
{VEGFR-PDGFR,VEGFR,c-Kit,FGFR,PDGFR,RET}

> <classes>
{Protein Tyrosine Kinase,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{9823820}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -7.7876   -1.5212    0.0000 C   0  0
   -9.0905   -0.7779    0.0000 O   0  0
   -7.7802   -3.0220    0.0000 N   0  0
   -9.0758   -3.7796    0.0000 C   0  0
   -9.0707   -5.2796    0.0000 C   0  0
  -10.3671   -6.0341    0.0000 C   0  0
  -11.6687   -5.2886    0.0000 C   0  0
  -12.9652   -6.0432    0.0000 C   0  0
  -11.6740   -3.7886    0.0000 C   0  0
  -12.9748   -3.0401    0.0000 N   0  0
  -12.9779   -1.5393    0.0000 C   0  0
  -14.2769   -0.7892    0.0000 N   0  0
  -14.2770    0.7108    0.0000 C   0  0
  -12.9780    1.4608    0.0000 C   0  0
  -11.6789    0.7109    0.0000 C   0  0
  -11.6789   -0.7891    0.0000 N   0  0
  -10.3792    1.4613    0.0000 C   0  0
  -10.3768    2.9613    0.0000 C   0  0
   -9.0766    3.7093    0.0000 C   0  0
   -7.7787    2.9573    0.0000 C   0  0
   -7.7811    1.4573    0.0000 N   0  0
   -9.0813    0.7093    0.0000 C   0  0
  -10.3776   -3.0341    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 12 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 29 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 31  1  0
 23 37  2  0
 37 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28423

> <plate>
Kinase v5-2

> <well>
C19

> <supplier_cmpd_name>
Imatinib(STI571)

> <ctcr_id>
1820

> <supplier_cmpd_id>
S2475

> <smiles>
CN1CCN(CC1)Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3

> <pd_targets>
{S,MAPK10,FYN,CLK1,CLK4,MAPK8,PDGFRA,DDR1,BRAF,ABL1,BCR,PDGFRB,FGR,GAK,LCK,MELK,KIT,SYK,CA7,NQO2,CDK19,KARS1,KDR,LMNA,FRK,TYK2,CA12,CA2,PLK2,PLK4,CA13,CA15,IRAK1,EPHA8,CYP3A4,ABL2,MAPK9,SRC,ABCB11,STK
17A,RAF1,DDR2,TNNI3K,MAP3K20,LYN,CSF1R,EGFR,MAPK14,CA9,CA4,CA5B,PIP4K2C,BLK,CA3,CA14,ALB,ABCB1,CA6,CA1,FLT3,CA5A,HIPK4,MAPK11,MAPK12,MAPK13,REP,RORC,TAOK1,RAD52,HRH2,SLC47A2,SLC22A3,ABCG2,SLC6A4,TBXAS
1,SLC47A1,SLC22A2,HTR2A,RET,NTRK1}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein",Transporter,"Secreted protein","Transcription factor","Membrane receptor",Kinase,Protease,Lyase,Oxidoreductase,"Cytochrome P450","Primary active transporter",Transferas
e,"Nuclear receptor","Family A G protein-coupled receptor","Electrochemical transporter","Protein Kinase","Cysteine protease","Cytochrome P450 family 3","ATP-binding cassette","Nuclear hormone recepto
r subfamily 1","Small molecule receptor (family A GPCR)","SLC superfamily of solute carriers","Cytochrome P450 family 5","CMGC protein kinase group","TK protein kinase group","TKL protein kinase group
","Atypical protein kinase group","Cysteine protease CA clan","Other protein kinase group","CAMK protein kinase group","Cytochrome P450 family 3A","ABCB subfamily","Nuclear hormone receptor subfamily 
1 group F","STE protein kinase group","Monoamine receptor","SLC47 family of multidrug and toxin extrusion transporters","SLC22 family of organic cation and anion transporters","ABCG subfamily","SLC06 
neurotransmitter transporter family","Cytochrome P450 family 5A","CMGC protein kinase MAPK family","Tyrosine protein kinase Src family","CMGC protein kinase CLK family","Tyrosine protein kinase PDGFR 
family","Tyrosine protein kinase DDR family","TKL protein kinase RAF family","Atypical protein kinase BCR family","Cysteine protease C1A family","Tyrosine protein kinase Abl family","Other protein kin
ase NAK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Syk family","CMGC protein kinase CDK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase JakA family","O
ther protein kinase PLK family","TKL protein kinase IRAK family","Tyrosine protein kinase Eph family","Cytochrome P450 3A4","CAMK protein kinase DAPK family","TKL protein kinase MLK family","Tyrosine 
protein kinase EGFR family","CMGC protein kinase DYRK family","Nuclear hormone receptor subfamily 1 group F member 3","STE protein kinase STE20 family","Histamine receptor","Cytochrome P450 5A1","Sero
tonin receptor","Tyrosine protein kinase Trk family","CMGC protein kinase JNK subfamily","Tyrosine protein kinase SrcA","CAMK protein kinase MELK subfamily","CMGC protein kinase CDK8 subfamily","Other
 protein kinase PLK2","TKL protein kinase HH498 subfamily","TKL protein kinase MLK subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase TAO subfamily
"}

> <pathway_chembl>
{"Other protein targets",Enzymes,Receptors,Transporters,"Anti-infective targets","Kinases (EC 2.7.x.x)","Catalytic receptors","Carbonic anhydrases","Cytochrome P450","ATP-binding cassette transporter 
family","Nuclear hormone receptors","G protein-coupled receptors","SLC superfamily of solute carriers","Viral protein targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CAMK:
 Calcium/calmodulin-dependent protein kinases","CYP3 family","ABCB subfamily","Lipid modifying kinases","1F. Retinoic acid-related orphans","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 
kinases","Histamine receptors","SLC47 family of multidrug and toxin extrusion transporters","SLC22 family of organic cation and anion transporters","ABCG subfamily","SLC6 neurotransmitter transporter 
family",CYP5,"CYP7 and CYP8 families","5-Hydroxytryptamine receptors",Atypical,"Coronavirus (CoV) proteins","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","CLK family","TKL: T
yrosine kinase-like","Other protein kinases","CAMK-like (CAMKL) family","Cyclin-dependent kinase (CDK) family","Death-associated kinase (DAPK) family","Type II PIP kinases (1-phosphatidylinositol-5-ph
osphate 4-kinase family)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","STE20 family","Organic cation transporters (OCT)","Monoamine transporter subfamily","BCR famil
y","JNK subfamily","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","RAF family","Numb-associated kinase (NAK) family","MELK subfamily","CDK8 subfamily","Polo-like kinase (PL
K) family","Interleukin-1 receptor-associated kinase (IRAK) family","Mixed Lineage Kinase (MLK) family","p38 subfamily","HIPK subfamily","TAO subfamily","Src family","Type III RTKs: PDGFR",CSFR,Kit,"F
LT3 receptor family","Type XVI RTKs: DDR (collagen receptor) family","Abl family","Syk family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Janus kinase (JakA) family","T
ype XIII RTKs: Ephrin receptor family","HH498 subfamily","MLK subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type VII RTKs: Neurotrophin receptor/Trk family"}

> <pathway_reactome>
{Disease,"Immune System","Extracellular matrix organization","Signal Transduction","Vesicle-mediated transport",Metabolism,"Metabolism of proteins","Cell Cycle","Transport of small molecules","Develop
mental Biology","Gene expression (Transcription)","Cellular responses to external stimuli","DNA Repair","Neuronal System","Infectious disease","Innate Immune System","Diseases of signal transduction b
y growth factor receptors and second messengers","Non-integrin membrane-ECM interactions","Signaling by Receptor Tyrosine Kinases","Membrane Trafficking","Intracellular signaling by second messengers"
,"Reversible hydration of carbon dioxide","Biological oxidations","Metabolism of lipids",Translation,Mitotic,"Cytokine Signaling in Immune system","O2/CO2 exchange in erythrocytes","Nervous system dev
elopment","MAPK family signaling cascades","RNA Polymerase II Transcription","Signaling by GPCR","Cellular responses to stress","Abacavir transport and metabolism","DNA Double-Strand Break Repair","SL
C-mediated transmembrane transport","Transmission across Chemical Synapses","SARS-CoV Infections","Toll-like Receptor Cascades","HIV Infection","Signaling by PDGFR in disease","Signaling by NTRKs","Le
ishmania infection","trans-Golgi Network Vesicle Budding","Signaling by KIT in disease","PIP3 activates AKT signaling","Phase I - Functionalization of compounds","Regulation of lipid metabolism by PPA
Ralpha","tRNA Aminoacylation","Signaling by VEGF","M Phase","Interferon Signaling","Erythrocytes take up carbon dioxide and release oxygen","Mitotic G2-G2/M phases","Axon guidance","Biosynthesis of sp
ecialized proresolving mediators (SPMs)","Metabolism of steroids","MAPK1/MAPK3 signaling","Generic Transcription Pathway","GPCR downstream signalling","Cellular response to hypoxia","Abacavir transmem
brane transport","Signaling by Interleukins","Signaling by Insulin receptor","Homology Directed Repair","Transport of bile salts and organic acids","metal ions and amine compounds","Neurotransmitter c
learance","GPCR ligand binding","Signaling by FGFR in disease","SARS-CoV-1 Infection","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","Drug resistance of PDGFR mutants","Signa
ling by NTRK1 (TRKA)","Parasite infection","Leishmania parasite growth and survival","Golgi Associated Vesicle Biogenesis","Drug resistance of KIT mutants","Negative regulation of the PI3K/AKT network
","PPARA activates gene expression","Cytosolic tRNA aminoacylation","VEGFA-VEGFR2 Pathway","Mitotic Metaphase and Anaphase","PTEN Regulation","Interferon alpha/beta signaling","G2/M Transition","EPH-E
phrin signaling","Biosynthesis of DHA-derived SPMs","Signaling by ROBO receptors","Bile acid and bile salt metabolism","RAF/MAP kinase cascade","Transcriptional Regulation by VENTX","G alpha (q) signa
lling events","Regulation of gene expression by Hypoxia-inducible Factor","Transcriptional Regulation by TP53","Transcriptional regulation by RUNX1","Interleukin-12 family signaling","Insulin receptor
 signalling cascade","Transcriptional regulation by RUNX3","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Organic cation/anion/zwitterion transport","Serotonin clearanc
e from the synaptic cleft","Cytochrome P450 - arranged by substrate type","Class A/1 (Rhodopsin-like receptors)","Signaling by FGFR1 in disease","Translation of structural proteins","MyD88 cascade ini
tiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Imatinib-resistant PDGFR mutants","Signalling to ERKs","Leishmania phagocytosis","Anti-inflammatory response
 favouring Leishmania parasite infection","Dasatinib-resistant KIT mutants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","VEGFR2 mediated cell proliferation","Mitotic Anaphase","Regulation of PTEN
 stability and activity","Regulation of IFNA signaling","Centrosome maturation","EPHA-mediated growth cone collapse","Biosynthesis of maresins","Role of ABL in ROBO-SLIT signaling","Synthesis of bile 
acids and bile salts","Negative regulation of MAPK pathway","Gastrin-CREB signalling pathway via PKC and MAPK","Regulation of TP53 Activity","RUNX1 regulates transcription of genes involved in BCR sig
naling","Recycling of bile acids and salts","Interleukin-12 signaling","IRS-mediated signalling","SARS-CoV-1 Genome Replication and Transcription","RUNX3 Regulates Immune Response and Cell Migration",
"HDR through Single Strand Annealing (SSA)","Organic cation transport",Eicosanoids,"Amine ligand-binding receptors","FGFR1 mutant receptor activation","Maturation of spike protein","MAP kinase activat
ion","Nef and signal transduction","Prolonged ERK activation events","FCGR3A-mediated phagocytosis","FCGR3A-mediated IL10 synthesis","Nef-mediates down modulation of cell surface receptors by recruiti
ng them to clathrin adapters","Nuclear Envelope (NE) Reassembly","CD163 mediating an anti-inflammatory response","Loss of proteins required for interphase microtubule organization from the centrosome"
,"Biosynthesis of maresin-like SPMs","Signalling to RAS","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","Negative feedback regulation of MAPK pathway","EGFR Transactivation by 
Gastrin","Regulation of TP53 Activity through Acetylation","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","PI3K Cascade","Replication of the SARS-CoV-1 genome","S
eparation of Sister Chromatids","ADORA2B mediated anti-inflammatory cytokines production","Serotonin receptors","Signaling by cytosolic FGFR1 fusion mutants","MAPK targets/ Nuclear events mediated by 
MAP kinases","ARMS-mediated activation","Nef Mediated CD4 Down-regulation","Initiation of Nuclear Envelope (NE) Reformation","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK ac
tivation","p38MAPK events","PI5P Regulates TP53 Acetylation","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{ABL1,CSF1R,DDR1,KIT,NTRK1,PDGFRA,PDGFRB,RET}

> <broad_moa>
{"Bcr-Abl kinase inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor"}

> <synonyms>
{Imatinib,152459-95-5,152459955,STI571,Glivec,"Imatinib (STI571)",sti-571,sti571,"Imatinib free base","Cgp 57148","STI 571",UNII-BKJ8M8G5HI,UNIIBKJ8M8G5HI,"Imatinib Methansulfonate",CGP-57148,CGP57148
,"152459-95-5 (free base)","152459955 (free base)",BKJ8M8G5HI,CHEMBL941,CHEBI:45783,NSC743414,"Imatinib (INN:BAN",T6230,743414,S2475,Prestw-1290,"NSC 743414",imatinib,Imatinib(STI571),IMATINIB,"Imatin
ib mesylate"}

> <pdid>
PD001319

> <targets>
{c-Kit,KIT,ABL,VEGFR-PDGFR,PDGFR}

> <classes>
{"Tyrosine kinase inhibitor"}

> <pubchem_cids>
{5291}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -7.7876   -1.5212    0.0000 C   0  0
   -9.0905   -0.7779    0.0000 O   0  0
   -7.7802   -3.0220    0.0000 N   0  0
   -9.0758   -3.7796    0.0000 C   0  0
   -9.0707   -5.2796    0.0000 C   0  0
  -10.3671   -6.0341    0.0000 C   0  0
  -11.6687   -5.2886    0.0000 C   0  0
  -12.9652   -6.0432    0.0000 C   0  0
  -11.6740   -3.7886    0.0000 C   0  0
  -12.9748   -3.0401    0.0000 N   0  0
  -12.9779   -1.5393    0.0000 C   0  0
  -14.2769   -0.7892    0.0000 N   0  0
  -14.2770    0.7108    0.0000 C   0  0
  -12.9780    1.4608    0.0000 C   0  0
  -11.6789    0.7109    0.0000 C   0  0
  -11.6789   -0.7891    0.0000 N   0  0
  -10.3792    1.4613    0.0000 C   0  0
  -10.3768    2.9613    0.0000 C   0  0
   -9.0766    3.7093    0.0000 C   0  0
   -7.7787    2.9573    0.0000 C   0  0
   -7.7811    1.4573    0.0000 N   0  0
   -9.0813    0.7093    0.0000 C   0  0
  -10.3776   -3.0341    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 12 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 29 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 31  1  0
 23 37  2  0
 37 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28424

> <plate>
Kinase v5-2

> <well>
C21

> <supplier_cmpd_name>
Imatinib Mesylate

> <ctcr_id>
1820

> <supplier_cmpd_id>
S1026

> <smiles>
CN1CCN(CC1)Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3

> <pd_targets>
{S,MAPK10,FYN,CLK1,CLK4,MAPK8,PDGFRA,DDR1,BRAF,ABL1,BCR,PDGFRB,FGR,GAK,LCK,MELK,KIT,SYK,CA7,NQO2,CDK19,KARS1,KDR,LMNA,FRK,TYK2,CA12,CA2,PLK2,PLK4,CA13,CA15,IRAK1,EPHA8,CYP3A4,ABL2,MAPK9,SRC,ABCB11,STK
17A,RAF1,DDR2,TNNI3K,MAP3K20,LYN,CSF1R,EGFR,MAPK14,CA9,CA4,CA5B,PIP4K2C,BLK,CA3,CA14,ALB,ABCB1,CA6,CA1,FLT3,CA5A,HIPK4,MAPK11,MAPK12,MAPK13,REP,RORC,TAOK1,RAD52,HRH2,SLC47A2,SLC22A3,ABCG2,SLC6A4,TBXAS
1,SLC47A1,SLC22A2,HTR2A,RET,NTRK1}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein",Transporter,"Secreted protein","Transcription factor","Membrane receptor",Kinase,Protease,Lyase,Oxidoreductase,"Cytochrome P450","Primary active transporter",Transferas
e,"Nuclear receptor","Family A G protein-coupled receptor","Electrochemical transporter","Protein Kinase","Cysteine protease","Cytochrome P450 family 3","ATP-binding cassette","Nuclear hormone recepto
r subfamily 1","Small molecule receptor (family A GPCR)","SLC superfamily of solute carriers","Cytochrome P450 family 5","CMGC protein kinase group","TK protein kinase group","TKL protein kinase group
","Atypical protein kinase group","Cysteine protease CA clan","Other protein kinase group","CAMK protein kinase group","Cytochrome P450 family 3A","ABCB subfamily","Nuclear hormone receptor subfamily 
1 group F","STE protein kinase group","Monoamine receptor","SLC47 family of multidrug and toxin extrusion transporters","SLC22 family of organic cation and anion transporters","ABCG subfamily","SLC06 
neurotransmitter transporter family","Cytochrome P450 family 5A","CMGC protein kinase MAPK family","Tyrosine protein kinase Src family","CMGC protein kinase CLK family","Tyrosine protein kinase PDGFR 
family","Tyrosine protein kinase DDR family","TKL protein kinase RAF family","Atypical protein kinase BCR family","Cysteine protease C1A family","Tyrosine protein kinase Abl family","Other protein kin
ase NAK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Syk family","CMGC protein kinase CDK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase JakA family","O
ther protein kinase PLK family","TKL protein kinase IRAK family","Tyrosine protein kinase Eph family","Cytochrome P450 3A4","CAMK protein kinase DAPK family","TKL protein kinase MLK family","Tyrosine 
protein kinase EGFR family","CMGC protein kinase DYRK family","Nuclear hormone receptor subfamily 1 group F member 3","STE protein kinase STE20 family","Histamine receptor","Cytochrome P450 5A1","Sero
tonin receptor","Tyrosine protein kinase Trk family","CMGC protein kinase JNK subfamily","Tyrosine protein kinase SrcA","CAMK protein kinase MELK subfamily","CMGC protein kinase CDK8 subfamily","Other
 protein kinase PLK2","TKL protein kinase HH498 subfamily","TKL protein kinase MLK subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase TAO subfamily
"}

> <pathway_chembl>
{"Other protein targets",Enzymes,Receptors,Transporters,"Anti-infective targets","Kinases (EC 2.7.x.x)","Catalytic receptors","Carbonic anhydrases","Cytochrome P450","ATP-binding cassette transporter 
family","Nuclear hormone receptors","G protein-coupled receptors","SLC superfamily of solute carriers","Viral protein targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CAMK:
 Calcium/calmodulin-dependent protein kinases","CYP3 family","ABCB subfamily","Lipid modifying kinases","1F. Retinoic acid-related orphans","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 
kinases","Histamine receptors","SLC47 family of multidrug and toxin extrusion transporters","SLC22 family of organic cation and anion transporters","ABCG subfamily","SLC6 neurotransmitter transporter 
family",CYP5,"CYP7 and CYP8 families","5-Hydroxytryptamine receptors",Atypical,"Coronavirus (CoV) proteins","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","CLK family","TKL: T
yrosine kinase-like","Other protein kinases","CAMK-like (CAMKL) family","Cyclin-dependent kinase (CDK) family","Death-associated kinase (DAPK) family","Type II PIP kinases (1-phosphatidylinositol-5-ph
osphate 4-kinase family)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","STE20 family","Organic cation transporters (OCT)","Monoamine transporter subfamily","BCR famil
y","JNK subfamily","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","RAF family","Numb-associated kinase (NAK) family","MELK subfamily","CDK8 subfamily","Polo-like kinase (PL
K) family","Interleukin-1 receptor-associated kinase (IRAK) family","Mixed Lineage Kinase (MLK) family","p38 subfamily","HIPK subfamily","TAO subfamily","Src family","Type III RTKs: PDGFR",CSFR,Kit,"F
LT3 receptor family","Type XVI RTKs: DDR (collagen receptor) family","Abl family","Syk family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Janus kinase (JakA) family","T
ype XIII RTKs: Ephrin receptor family","HH498 subfamily","MLK subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type VII RTKs: Neurotrophin receptor/Trk family"}

> <pathway_reactome>
{Disease,"Immune System","Extracellular matrix organization","Signal Transduction","Vesicle-mediated transport",Metabolism,"Metabolism of proteins","Cell Cycle","Transport of small molecules","Develop
mental Biology","Gene expression (Transcription)","Cellular responses to external stimuli","DNA Repair","Neuronal System","Infectious disease","Innate Immune System","Diseases of signal transduction b
y growth factor receptors and second messengers","Non-integrin membrane-ECM interactions","Signaling by Receptor Tyrosine Kinases","Membrane Trafficking","Intracellular signaling by second messengers"
,"Reversible hydration of carbon dioxide","Biological oxidations","Metabolism of lipids",Translation,Mitotic,"Cytokine Signaling in Immune system","O2/CO2 exchange in erythrocytes","Nervous system dev
elopment","MAPK family signaling cascades","RNA Polymerase II Transcription","Signaling by GPCR","Cellular responses to stress","Abacavir transport and metabolism","DNA Double-Strand Break Repair","SL
C-mediated transmembrane transport","Transmission across Chemical Synapses","SARS-CoV Infections","Toll-like Receptor Cascades","HIV Infection","Signaling by PDGFR in disease","Signaling by NTRKs","Le
ishmania infection","trans-Golgi Network Vesicle Budding","Signaling by KIT in disease","PIP3 activates AKT signaling","Phase I - Functionalization of compounds","Regulation of lipid metabolism by PPA
Ralpha","tRNA Aminoacylation","Signaling by VEGF","M Phase","Interferon Signaling","Erythrocytes take up carbon dioxide and release oxygen","Mitotic G2-G2/M phases","Axon guidance","Biosynthesis of sp
ecialized proresolving mediators (SPMs)","Metabolism of steroids","MAPK1/MAPK3 signaling","Generic Transcription Pathway","GPCR downstream signalling","Cellular response to hypoxia","Abacavir transmem
brane transport","Signaling by Interleukins","Signaling by Insulin receptor","Homology Directed Repair","Transport of bile salts and organic acids","metal ions and amine compounds","Neurotransmitter c
learance","GPCR ligand binding","Signaling by FGFR in disease","SARS-CoV-1 Infection","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","Drug resistance of PDGFR mutants","Signa
ling by NTRK1 (TRKA)","Parasite infection","Leishmania parasite growth and survival","Golgi Associated Vesicle Biogenesis","Drug resistance of KIT mutants","Negative regulation of the PI3K/AKT network
","PPARA activates gene expression","Cytosolic tRNA aminoacylation","VEGFA-VEGFR2 Pathway","Mitotic Metaphase and Anaphase","PTEN Regulation","Interferon alpha/beta signaling","G2/M Transition","EPH-E
phrin signaling","Biosynthesis of DHA-derived SPMs","Signaling by ROBO receptors","Bile acid and bile salt metabolism","RAF/MAP kinase cascade","Transcriptional Regulation by VENTX","G alpha (q) signa
lling events","Regulation of gene expression by Hypoxia-inducible Factor","Transcriptional Regulation by TP53","Transcriptional regulation by RUNX1","Interleukin-12 family signaling","Insulin receptor
 signalling cascade","Transcriptional regulation by RUNX3","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Organic cation/anion/zwitterion transport","Serotonin clearanc
e from the synaptic cleft","Cytochrome P450 - arranged by substrate type","Class A/1 (Rhodopsin-like receptors)","Signaling by FGFR1 in disease","Translation of structural proteins","MyD88 cascade ini
tiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Imatinib-resistant PDGFR mutants","Signalling to ERKs","Leishmania phagocytosis","Anti-inflammatory response
 favouring Leishmania parasite infection","Dasatinib-resistant KIT mutants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","VEGFR2 mediated cell proliferation","Mitotic Anaphase","Regulation of PTEN
 stability and activity","Regulation of IFNA signaling","Centrosome maturation","EPHA-mediated growth cone collapse","Biosynthesis of maresins","Role of ABL in ROBO-SLIT signaling","Synthesis of bile 
acids and bile salts","Negative regulation of MAPK pathway","Gastrin-CREB signalling pathway via PKC and MAPK","Regulation of TP53 Activity","RUNX1 regulates transcription of genes involved in BCR sig
naling","Recycling of bile acids and salts","Interleukin-12 signaling","IRS-mediated signalling","SARS-CoV-1 Genome Replication and Transcription","RUNX3 Regulates Immune Response and Cell Migration",
"HDR through Single Strand Annealing (SSA)","Organic cation transport",Eicosanoids,"Amine ligand-binding receptors","FGFR1 mutant receptor activation","Maturation of spike protein","MAP kinase activat
ion","Nef and signal transduction","Prolonged ERK activation events","FCGR3A-mediated phagocytosis","FCGR3A-mediated IL10 synthesis","Nef-mediates down modulation of cell surface receptors by recruiti
ng them to clathrin adapters","Nuclear Envelope (NE) Reassembly","CD163 mediating an anti-inflammatory response","Loss of proteins required for interphase microtubule organization from the centrosome"
,"Biosynthesis of maresin-like SPMs","Signalling to RAS","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","Negative feedback regulation of MAPK pathway","EGFR Transactivation by 
Gastrin","Regulation of TP53 Activity through Acetylation","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","PI3K Cascade","Replication of the SARS-CoV-1 genome","S
eparation of Sister Chromatids","ADORA2B mediated anti-inflammatory cytokines production","Serotonin receptors","Signaling by cytosolic FGFR1 fusion mutants","MAPK targets/ Nuclear events mediated by 
MAP kinases","ARMS-mediated activation","Nef Mediated CD4 Down-regulation","Initiation of Nuclear Envelope (NE) Reformation","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK ac
tivation","p38MAPK events","PI5P Regulates TP53 Acetylation","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{ABL1,CSF1R,DDR1,KIT,NTRK1,PDGFRA,PDGFRB,RET}

> <broad_moa>
{"Bcr-Abl kinase inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor"}

> <synonyms>
{Imatinib,152459-95-5,152459955,STI571,Glivec,"Imatinib (STI571)",sti-571,sti571,"Imatinib free base","Cgp 57148","STI 571",UNII-BKJ8M8G5HI,UNIIBKJ8M8G5HI,"Imatinib Methansulfonate",CGP-57148,CGP57148
,"152459-95-5 (free base)","152459955 (free base)",BKJ8M8G5HI,CHEMBL941,CHEBI:45783,NSC743414,"Imatinib (INN:BAN",T6230,743414,S2475,Prestw-1290,"NSC 743414",imatinib,Imatinib(STI571),IMATINIB,"Imatin
ib mesylate"}

> <pdid>
PD001319

> <targets>
{c-Kit,KIT,ABL,VEGFR-PDGFR,PDGFR}

> <classes>
{"Tyrosine kinase inhibitor"}

> <pubchem_cids>
{5291}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
   14.2912    0.7774    0.0000 C   0  0
   12.9906    1.5248    0.0000 C   0  0
   11.6919    0.7725    0.0000 C   0  0
   10.3906    1.5203    0.0000 N   0  0
    9.0920    0.7681    0.0000 C   0  0
    9.0945   -0.7319    0.0000 O   0  0
    7.7907    1.5158    0.0000 N   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8994   -3.7478    0.0000 O   0  0
   -5.1973   -2.9959    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 O   0  0
    0.0042   -5.9990    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    5.1852    3.0091    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 19 22  2  0
 22 23  1  0
 23 24  1  0
 22 25  1  0
 25 26  2  0
 26 13  1  0
 26 17  1  0
 11 27  1  0
 27 28  2  0
 28  8  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28425

> <plate>
Kinase v5-2

> <well>
E03

> <supplier_cmpd_name>
KRN 633

> <ctcr_id>
1264

> <supplier_cmpd_id>
S1557

> <smiles>
CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl

> <pd_targets>
{KDR,KIT,FLT1,FLT4,PDGFRA}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: P
DGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by VEGF","Signaling by KIT in dise
ase","Signaling by PDGFR in disease","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","VEGF ligand-receptor interactions","Drug resistance of PDGFR mutants","VEGFR2 mediated cell proliferation"
,"Dasatinib-resistant KIT mutants","VEGF binds to VEGFR leading to receptor dimerization","Imatinib-resistant PDGFR mutants"}

> <broad_targets>
{FLT1,FLT4,KDR}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{KRN-633,KRN633,286370-15-8,286370158,"KRN 633",K00589a,"1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea","1(2chloro4(6,7dimethoxyquinazolin4yloxy)phenyl)3propylurea",CHEMBL406381,
"VEGF receptor tyrosine kinase inhibitor III",UNII-E1V875I8DX,UNIIE1V875I8DX,E1V875I8DX,1-(2-chloro-4-((6,1(2chloro4((6,7-dimethoxyquinazolin-4-y,7dimethoxyquinazolin4y,T6137,S1557}

> <pdid>
PD010972

> <targets>
{VEGFR-PDGFR}

> <classes>
{}

> <pubchem_cids>
{9549295}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 40  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -7.7876   -1.5212    0.0000 C   0  0
   -9.0905   -0.7779    0.0000 O   0  0
   -7.7802   -3.0220    0.0000 N   0  0
   -9.0758   -3.7796    0.0000 C   0  0
   -9.0707   -5.2796    0.0000 C   0  0
  -10.3671   -6.0341    0.0000 C   0  0
  -11.6687   -5.2886    0.0000 C   0  0
  -12.9652   -6.0432    0.0000 C   0  0
  -11.6740   -3.7886    0.0000 C   0  0
  -12.9748   -3.0401    0.0000 N   0  0
  -12.9779   -1.5393    0.0000 C   0  0
  -14.1914   -0.6794    0.0000 S   0  0
  -13.7279    0.7471    0.0000 C   0  0
  -12.2279    0.7472    0.0000 C   0  0
  -11.7644   -0.6794    0.0000 N   0  0
  -11.3458    1.9613    0.0000 C   0  0
  -11.8503    3.3687    0.0000 C   0  0
  -10.8798    4.5124    0.0000 C   0  0
   -9.4040    4.2438    0.0000 C   0  0
   -8.8987    2.8315    0.0000 N   0  0
   -9.8692    1.6877    0.0000 C   0  0
  -10.3776   -3.0341    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 12 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 25  2  0
 28 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
 23 36  2  0
 36 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28426

> <plate>
Kinase v5-2

> <well>
E05

> <supplier_cmpd_name>
Masitinib(AB1010)

> <ctcr_id>
1175

> <supplier_cmpd_id>
S1064

> <smiles>
CN1CCN(CC1)Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4scc(n4)c5cccnc5)c3

> <pd_targets>
{EPHA8,LYN,ABL1,PDGFRA,KIT,FYN,DDR1,YES1,CSF1R,FGR,EGFR,PDGFRB,EPHA3,SRC,BLK,ERBB2,DDR2,LCK,BRAF,PIM3,HCK,PIM1,MAP3K20,ABL2,RIOK2,FRK,FGFR3,FGFR1,FGFR2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","CAMK protein kinase group","Atypical protein kinase group","Tyrosine protein kinase Eph family","Tyrosine protein 
kinase Src family","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase DDR family","Tyrosine protein kinase EGFR family","TKL protein kinase RAF family
","CAMK protein kinase PIM family","TKL protein kinase MLK family","Atypical protein kinase RIO family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase SrcA","TKL protein kinase MLK sub
family","Atypical protein kinase RIO2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases",Atypical,"TK: Tyrosine kinase","TKL: Tyrosine kinase-like","PIM 
family","RIO family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","RAF family","Mixed Lineage Kinase (MLK) family","RIO2 subfamily","Type XIII RTKs: Ephrin receptor famil
y","Src family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XVI RTKs: DDR (collagen receptor) family","Type I RTKs: ErbB (epidermal growth factor) receptor family","MLK s
ubfamily","Type V RTKs: FGF (fibroblast growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology",Disease,"Extracellular matrix organization","Gene expression (Transcription)","Signal Transduction","Metabolism of RNA","Nervous system development","Infectious disease","Dise
ases of signal transduction by growth factor receptors and second messengers","Non-integrin membrane-ECM interactions","RNA Polymerase II Transcription","Signaling by GPCR","Intracellular signaling by
 second messengers","Signaling by Receptor Tyrosine Kinases","rRNA processing","Axon guidance","Leishmania infection","Signaling by PDGFR in disease","Signaling by KIT in disease","HIV Infection","Gen
eric Transcription Pathway","GPCR downstream signalling","PIP3 activates AKT signaling","Signaling by NTRKs","FLT3 signaling in disease","rRNA processing in the nucleus and cytosol","Signaling by FGFR
 in disease","EPH-Ephrin signaling","Leishmania parasite growth and survival","Parasite infection","Drug resistance of PDGFR mutants","Drug resistance of KIT mutants","Host Interactions of HIV factors
","Transcriptional Regulation by VENTX","G alpha (q) signalling events","Negative regulation of the PI3K/AKT network","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX1","Semaphorin inte
ractions","Signaling by FLT3 ITD and TKD mutants","Signaling by ROBO receptors","Major pathway of rRNA processing in the nucleolus and cytosol","PTEN Regulation","Signaling by FGFR3 in disease","Signa
ling by FGFR1 in disease","Signaling by FGFR2 in disease","EPHA-mediated growth cone collapse","Anti-inflammatory response favouring Leishmania parasite infection","Leishmania phagocytosis","Imatinib-
resistant PDGFR mutants","Dasatinib-resistant KIT mutants","The role of Nef in HIV-1 replication and disease pathogenesis","Gastrin-CREB signalling pathway via PKC and MAPK",PI5P,"PP2A and IER3 Regula
te PI3K/AKT Signaling","Signalling to ERKs","RUNX1 regulates transcription of genes involved in BCR signaling","Sema4D in semaphorin signaling","STAT5 activation downstream of FLT3 ITD mutants","Role 
of ABL in ROBO-SLIT signaling","Regulation of PTEN stability and activity","Signaling by FGFR3 point mutants in cancer","FGFR1 mutant receptor activation","FGFR2 mutant receptor activation","FCGR3A-me
diated IL10 synthesis","FCGR3A-mediated phagocytosis","Nef and signal transduction","EGFR Transactivation by Gastrin","Signalling to RAS","Sema4D induced cell migration and growth-cone collapse","Nef-
mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Prolonged ERK activation events","FGFR3 mutant receptor activation","Signaling by activated point mutants o
f FGFR1","Activated point mutants of FGFR2","p38MAPK events","Nef Mediated CD4 Down-regulation","ARMS-mediated activation","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
{FGFR3,KIT,PDGFRA,PDGFRB}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","SRC inhibitor"}

> <synonyms>
{s1064,ZINC34177219,AKOS005146325,Masitinib,790299-79-5,790299795,"790299 79 5",AB1010,Masatinib,"Masitinib (AB1010)",AB-1010,"AB 1010",Masivet,UNII-M59NC4E26P,UNIIM59NC4E26P,"UNII M59NC4E26P","Masiti
nib (INN)",M59NC4E26P,CHEMBL1908391,CHEBI:63450,MFCD09954132,C28H30N6OS,"Kinavet CA-1","Kinavet CA1","Kinavet CA 1",Mastinib,G65,Mas,T2609,S1064,masitinib,Masitinib(AB1010),MASITINIB}

> <pdid>
PD003354

> <targets>
{"c-Kit | VEGFR-PDGFR",c-Kit,FGFR,PDGFR,Apoptosis,FAK,Src}

> <classes>
{Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{10074640}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 40  0  0  0  0            999 V2000
    2.5840   -8.2829    0.0000 C   0  0
    2.8570   -6.8080    0.0000 N   0  0
    4.2107   -6.1619    0.0000 C   0  0
    4.0146   -4.6747    0.0000 N   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.8242   -5.7201    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 O   0  0
    2.5951    3.0039    0.0000 C   0  0
    1.2934    3.7495    0.0000 C   0  0
    1.2883    5.2495    0.0000 C   0  0
    2.5847    6.0040    0.0000 C   0  0
    2.5826    7.5048    0.0000 N   0  0
    3.8808    8.2579    0.0000 C   0  0
    5.1811    7.5101    0.0000 S   0  0
    3.8787    9.7587    0.0000 N   0  0
    5.1769   10.5118    0.0000 C   0  0
    6.4772    9.7640    0.0000 O   0  0
    5.1748   12.0126    0.0000 C   0  0
    6.4730   12.7657    0.0000 C   0  0
    6.4731   14.2657    0.0000 C   0  0
    7.7722   15.0157    0.0000 C   0  0
    9.0712   14.2657    0.0000 C   0  0
    9.0712   12.7657    0.0000 C   0  0
    7.7722   12.0157    0.0000 C   0  0
    3.8863    5.2585    0.0000 C   0  0
    3.8915    3.7585    0.0000 C   0  0
    5.1932    3.0131    0.0000 F   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 15 29  1  0
 29 30  2  0
 30 12  1  0
 30 31  1  0
 10 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35  9  1  0
 35 36  1  0
 36  7  2  0
M  END
> <name>
UTKinase_V5

> <id>
28427

> <plate>
Kinase v5-2

> <well>
E07

> <supplier_cmpd_name>
MGCD-265

> <ctcr_id>
5101

> <supplier_cmpd_id>
S1361

> <smiles>
Cn1cnc(c1)c2sc3c(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)ccnc3c2

> <pd_targets>
{MET,KDR,SMO,AURKA}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor",Kinase,"Frizzled family G protein-coupled receptor","Protein Kinase","Smoothened receptor (frizzled family GPCR)","TK protein kinase group","Other protein kinase group","Ty
rosine protein kinase Met family","Tyrosine protein kinase VEGFR family","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","G protein-coupled receptors","Receptor kinases","Class Frizzled GPCRs","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kinases (RTKs)","Aurora kinase
 (Aur) family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction","Organelle biogenesis and maintenance","Gene expression (Transcription)","Nervous system development","Signaling by Receptor Tyrosine Kinases","Cilium As
sembly","RNA Polymerase II Transcription","Axon guidance","Signaling by VEGF","Cargo trafficking to the periciliary membrane","Generic Transcription Pathway","Semaphorin interactions","VEGFA-VEGFR2 Pa
thway","BBSome-mediated cargo-targeting to cilium","Transcriptional Regulation by TP53","Sema4D in semaphorin signaling","VEGFR2 mediated cell proliferation","Regulation of TP53 Activity","Sema4D medi
ated inhibition of cell attachment and migration","Regulation of TP53 Activity through Phosphorylation"}

> <broad_targets>
{AXL,MET}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{GCD26,MGCD-265,MGCD265,875337-44-3,875337443,"MGCD-265 analog","MGCD265 analog",mgcd-265-analog,mgcd265analog,"MGCD 265",UNII-93M6577H9D,UNII93M6577H9D,CHEMBL254760,93M6577H9D,"compound 10a (PMID: 18
434145)",cc-38,cc38,MLS006010962,GTPL9133,SCHEMBL3576588,C26H20FN5O2S2,MGCD-265/MGCD265,MGCD265/MGCD265,BDBM24498,CHEBI:91393,DTXS,T6351,S1361,Glesatinib}

> <pdid>
PD003416

> <targets>
{"c-Met | VEGFR-PDGFR",c-Met,VEGFR,Tie-2}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{24901704}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 39  0  0  0  0            999 V2000
    1.7044    2.3130    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.2948   -3.7517    0.0000 O   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 N   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
   -2.5952   -6.0101    0.0000 N   0  0
   -2.5973   -7.5110    0.0000 C   0  0
   -1.2991   -8.2641    0.0000 C   0  0
   -1.2991   -9.7641    0.0000 C   0  0
   -0.0001  -10.5141    0.0000 C   0  0
    1.2990   -9.7642    0.0000 N   0  0
    1.2991   -8.2642    0.0000 C   0  0
    0.0000   -7.5141    0.0000 C   0  0
    4.1964    1.5037    0.0000 C   0  0
    6.6851   -4.8548    0.0000 O   0  0
    7.9844   -4.1052    0.0000 P   0  0
    9.2836   -4.8548    0.0000 O   0  0
    7.9844   -2.6052    0.0000 O   0  0
    7.9844   -5.6052    0.0000 O   0  0
   11.7851   -4.8548    0.0000 O   0  0
   13.0843   -4.1052    0.0000 P   0  0
   14.3836   -4.8548    0.0000 O   0  0
   13.0843   -2.6052    0.0000 O   0  0
   13.0843   -5.6052    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  3
  6  2  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  3
 10  5  1  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  3
 15 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  3
 19 14  1  0
 15 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  3
 23 24  1  0
 24 25  2  3
 25 26  1  0
 26 27  2  3
 27 22  1  0
  2 28  1  0
 29 30  1  0
 30 31  2  0
 30 32  1  0
 30 33  1  0
 34 35  1  0
 35 36  2  0
 35 37  1  0
 35 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28428

> <plate>
Kinase v5-2

> <well>
E09

> <supplier_cmpd_name>
Motesanib Diphosphate

> <ctcr_id>
6626

> <supplier_cmpd_id>
S1032

> <smiles>
CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O

> <pd_targets>
{KDR,ABL1,FGR,FLT1,FLT4,FLT3,EGFR,SLK,BLK,BRAF,MAP3K19,MAP3K7,MAP3K20,AURKC,RET,FRK,KIT,PDGFRB,YES1,LYN,PDGFRA,STK10,EPHA6,CIT,LCK,FYN,EIF2AK4,ABL2,CSF1R,RIPK2,JAK1,MAP3K2,HCK,PTK6,RAF1,FGFR1,MAP4K4,T
NNI3K,FGFR4,STK35,MAP3K3,DDR1,EPHA7}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","STE protein kinase group","TKL protein kinase group","Other protein kinase group","AGC protein kinase group","Tyrosine protein kinase VEGFR f
amily","Tyrosine protein kinase Abl family","Tyrosine protein kinase Src family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase EGFR family","STE protein kinase STE20 family","TKL pro
tein kinase RAF family","STE protein kinase STE11 family","TKL protein kinase MLK family","Other protein kinase AUR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Eph family","A
GC protein kinase DMPK family","Other protein kinase PEK family","TKL protein kinase RIPK family","Tyrosine protein kinase JakA family","Tyrosine protein kinase FGFR family","Other protein kinase NKF4
 family","Tyrosine protein kinase DDR family","STE protein kinase SLK subfamily","TKL protein kinase TAK1 subfamily","TKL protein kinase MLK subfamily","AGC protein kinase CRIK subfamily","Tyrosine pr
otein kinase SrcA","Other protein kinase GCN2 subfamily","STE protein kinase MEKK2","STE protein kinase MSN subfamily","TKL protein kinase HH498 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","TK: Ty
rosine kinase","STE20 family","TKL: Tyrosine kinase-like","Other protein kinases","DMPK family","STE11 family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","SLK subfamily
","RAF family","STE20 subfamily","Mixed Lineage Kinase (MLK) family","Aurora kinase (Aur) family","Other DMPK family kinases","PEK family","Receptor interacting protein kinase (RIPK) family","MSN subf
amily","NKF4 family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Abl family","Src family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type I RTKs: ErbB (epid
ermal growth factor) receptor family","TAK1 subfamily","MLK subfamily","Type XIV RTKs: RET","Type XIII RTKs: Ephrin receptor family","GCN2 subfamily","Janus kinase (JakA) family","Type V RTKs: FGF (fi
broblast growth factor) receptor family","HH498 subfamily","Type XVI RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Gene expression (Transcription)","Immune System","Developmental Biology","Cellular responses to external stimuli","Cell Cycle","Extracellular matrix organization","Sign
aling by Receptor Tyrosine Kinases","Infectious disease","Signaling by GPCR","RNA Polymerase II Transcription","Innate Immune System","Nervous system development","Intracellular signaling by second me
ssengers","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Rho GTPases","Cellular responses to stress","Cytokine Signaling in Immune system",Mitotic,"MA
PK family signaling cascades","Non-integrin membrane-ECM interactions","Signaling by VEGF","Leishmania infection","Signaling by Insulin receptor","GPCR downstream signalling","Generic Transcription Pa
thway","Signaling by NTRKs","Toll-like Receptor Cascades","Axon guidance","PIP3 activates AKT signaling","Signaling by KIT in disease","Signaling by PDGFR in disease","Neutrophil degranulation","RHO G
TPase Effectors","HIV Infection","Response of EIF2AK4 (GCN2) to amino acid deficiency","Interferon Signaling","Mitotic G1 phase and G1/S transition","MAPK1/MAPK3 signaling","Signaling by FGFR in disea
se","Cellular Senescence","Signaling by FGFR","Signaling by Interleukins","VEGFA-VEGFR2 Pathway","Parasite infection","Leishmania parasite growth and survival","VEGF ligand-receptor interactions","Ins
ulin receptor signalling cascade","G alpha (q) signalling events","Transcriptional regulation by RUNX1","Signaling by NTRK1 (TRKA)","Toll Like Receptor 4 (TLR4) Cascade","RET signaling","PTEN Regulati
on","Drug resistance of KIT mutants","Negative regulation of the PI3K/AKT network","Drug resistance of PDGFR mutants","EPH-Ephrin signaling","RHO GTPases activate CIT","Host Interactions of HIV factor
s","Signaling by ROBO receptors","Transcriptional Regulation by VENTX","Toll Like Receptor 5 (TLR5) Cascade","Antiviral mechanism by IFN-stimulated genes","G1 Phase","RAF/MAP kinase cascade","Signalin
g by FGFR1 in disease","Oxidative Stress Induced Senescence","Signaling by FGFR4","Interleukin-1 family signaling","VEGFR2 mediated cell proliferation","Leishmania phagocytosis","Anti-inflammatory res
ponse favouring Leishmania parasite infection","VEGF binds to VEGFR leading to receptor dimerization","IRS-mediated signalling","Gastrin-CREB signalling pathway via PKC and MAPK","RUNX1 regulates tran
scription of genes involved in BCR signaling","Signalling to ERKs","MyD88-independent TLR4 cascade","Regulation of PTEN stability and activity","Dasatinib-resistant KIT mutants",PI5P,"PP2A and IER3 Re
gulate PI3K/AKT Signaling","Imatinib-resistant PDGFR mutants","EPHA-mediated growth cone collapse","The role of Nef in HIV-1 replication and disease pathogenesis","Role of ABL in ROBO-SLIT signaling",
"MyD88 cascade initiated on plasma membrane","ISG15 antiviral mechanism","Cyclin D associated events in G1","Negative regulation of MAPK pathway","FGFR1 mutant receptor activation","Downstream signali
ng of activated FGFR4","Interleukin-1 signaling","FCGR3A-mediated phagocytosis","FCGR3A-mediated IL10 synthesis","PI3K Cascade","EGFR Transactivation by Gastrin","Prolonged ERK activation events","TRI
F(TICAM1)-mediated TLR4 signaling","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Nef and signal transduction","MAP kinase activation","Negative feed
back regulation of MAPK pathway","Signaling by activated point mutants of FGFR1","FRS-mediated FGFR4 signaling","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex
","Nef Mediated CD4 Down-regulation","activated TAK1 mediates p38 MAPK activation"}

> <broad_targets>
{FLT1,FLT4,KDR,KIT}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{DTXSID30235080,"Motesanib diphosphate",857876-30-3,857876303,AMG-706,AMG706,"Motesanib (Diphosphate)","Motesanib Diphosphate (AMG-706)","Motesanib Diphosphate (AMG706)",UNII-T6Q3060U91,UNIIT6Q3060U91
,"AMG 706 (Diphosphate)","Motesanib diphosphate (USAN)","AMG 706;",T6Q3060U91,"AMG-706 diphosphat","AMG706 diphosphat",S1032,"Motesanib Diphosphate"}

> <pdid>
PD012969

> <targets>
{VEGFR-PDGFR}

> <classes>
{}

> <pubchem_cids>
{16097729}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 37  0  0  0  0            999 V2000
    7.7931   -3.0140    0.0000 S   0  0
    6.4915   -3.7597    0.0000 C   0  0
    6.4870   -5.2605    0.0000 N   0  0
    7.7840   -6.0157    0.0000 C   0  0
    7.7795   -7.5165    0.0000 C   0  0
    9.0747   -8.2731    0.0000 C   0  0
    9.0672   -9.7731    0.0000 C   0  0
    7.7644  -10.5165    0.0000 C   0  0
    7.4455  -11.9814    0.0000 O   0  0
    5.9530  -12.1307    0.0000 C   0  0
    5.3498  -10.7573    0.0000 O   0  0
    6.4691   -9.7600    0.0000 C   0  0
    6.4767   -8.2600    0.0000 C   0  0
    5.1945   -3.0045    0.0000 N   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 O   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.6837   -4.3363    0.0000 C   0  0
   -4.1755   -4.1795    0.0000 C   0  0
   -4.7856   -2.8092    0.0000 C   0  0
   -3.9040   -1.5957    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  8  1  0
 12 13  2  0
 13  5  1  0
  2 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
 17 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 24  1  0
 32 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28429

> <plate>
Kinase v5-2

> <well>
E11

> <supplier_cmpd_name>
MP-470

> <ctcr_id>
532

> <supplier_cmpd_id>
S1244

> <smiles>
S=C(NCc1ccc2OCOc2c1)N3CCN(CC3)c4ncnc5c4oc6ccccc56

> <pd_targets>
{KIT,FLT3,PDGFRA,MET,RET,PDGFRB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type X RTKs: HGF (hepatocyte growth
 factor) receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Developmental Biology","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","Nervous system devel
opment","Intracellular signaling by second messengers","Signaling by KIT in disease","Signaling by Insulin receptor","Signaling by PDGFR in disease","Axon guidance","PIP3 activates AKT signaling","Dru
g resistance of KIT mutants","Insulin receptor signalling cascade","Drug resistance of PDGFR mutants","Semaphorin interactions","Negative regulation of the PI3K/AKT network","Dasatinib-resistant KIT m
utants","IRS-mediated signalling","Imatinib-resistant PDGFR mutants","Sema4D in semaphorin signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","PI3K Cascade","Sema4D mediated inhibition of cel
l attachment and migration"}

> <broad_targets>
{KIT,MET}

> <broad_moa>
{"FLT3 inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","RAD51 inhibitor","RET tyrosine kinase inhibitor"}

> <synonyms>
{"MUVATINIB (MP470",Amuvatinib,850879-09-3,850879093,MP-470,MP470,"Amuvatinib (MP-470)","Amuvatinib (MP470)","MP 470",HPK56,"HPK 56",UNII-SO9S6QZB4R,UNIISO9S6QZB4R,"Amuvatinib (MP-470, HPK 56)","Amuva
tinib (MP470, HPK 56)",SO9S6QZB4R,HPK-56,"Amuvatinib (USAN:INN)",Amuvatinib(MP470),PubChem22479,"Amuvatinib (USAN/INN)",SCHEMBL9,T2516,S1244}

> <pdid>
PD011043

> <targets>
{"c-Kit | VEGFR-PDGFR",c-Met,Flt,c-Kit,FLT3,c-RET,PDGFR,Apoptosis,c-Met/HGFR,RAD51,RET}

> <classes>
{Protein Tyrosine Kinase,Apoptosis,Cell Cycle/DNA Damage,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{11282283}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    8.6552    9.4120    0.0000 F   0  0
    8.3576    7.9418    0.0000 C   0  0
    6.9355    7.4648    0.0000 F   0  0
    7.2333    8.9348    0.0000 F   0  0
    9.4820    6.9477    0.0000 O   0  0
    9.1843    5.4767    0.0000 C   0  0
   10.3067    4.4816    0.0000 C   0  0
   10.0061    3.0121    0.0000 C   0  0
    8.5831    2.5375    0.0000 C   0  0
    8.2794    1.0677    0.0000 N   0  0
    6.8550    0.5950    0.0000 C   0  0
    5.7343    1.5920    0.0000 O   0  0
    6.5517   -0.8722    0.0000 C   0  0
    7.5554   -1.9869    0.0000 S   0  0
    6.8054   -3.2859    0.0000 C   0  0
    5.3382   -2.9741    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    7.4607    3.5327    0.0000 C   0  0
    7.7613    5.0023    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 13  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 20  1  0
 29 24  1  0
  9 30  1  0
 30 31  2  0
 31  6  1  0
M  END
> <name>
UTKinase_V5

> <id>
28430

> <plate>
Kinase v5-2

> <well>
E13

> <supplier_cmpd_name>
OSI-930

> <ctcr_id>
6873

> <supplier_cmpd_id>
S1220

> <smiles>
FC(F)(F)Oc1ccc(NC(=O)c2sccc2NCc3ccnc4ccccc34)cc1

> <pd_targets>
{KIT,CYP3A4,RAF1,KDR,LCK,CSF1R,FLT1,FLT4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 3","TK protein kinase group","Cytochrome P450 family 3A","TKL protein kinase group","Tyrosine protein kinase PDGFR family","Cy
tochrome P450 3A4","TKL protein kinase RAF family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Cytochrome P450","Receptor kinases","CYP3 family","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Receptor tyrosine kinases (RTKs)","RAF family","Non-recep
tor tyrosine kinases (nRTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Src family"}

> <pathway_reactome>
{Disease,Metabolism,"Signal Transduction","Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","MAPK family signa
ling cascades","Signaling by Receptor Tyrosine Kinases","Infectious disease","RNA Polymerase II Transcription","Signaling by KIT in disease","Biosynthesis of specialized proresolving mediators (SPMs)"
,"MAPK1/MAPK3 signaling","Signaling by VEGF","HIV Infection","Generic Transcription Pathway","Drug resistance of KIT mutants","Biosynthesis of DHA-derived SPMs","RAF/MAP kinase cascade","VEGFA-VEGFR2 
Pathway","Host Interactions of HIV factors","Transcriptional Regulation by VENTX","VEGF ligand-receptor interactions","Dasatinib-resistant KIT mutants","Biosynthesis of maresins","Negative regulation 
of MAPK pathway","VEGFR2 mediated cell proliferation","The role of Nef in HIV-1 replication and disease pathogenesis","VEGF binds to VEGFR leading to receptor dimerization","Biosynthesis of maresin-li
ke SPMs","Negative feedback regulation of MAPK pathway","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Nef Mediated CD4 Down-regulation"}

> <broad_targets>
{FLT1,KDR,KIT}

> <broad_moa>
{"KIT inhibitor","VEGFR inhibitor"}

> <synonyms>
{SI93,G1PEG5Q9Y2,CHEMBL1614710,C22H16F3N3O2S,cc-339,cc339,MLS006010277,SCHEMBL633719,GTPL9383,CHEBI:91433,DTXSID60993606,HMS3295O11,HMS3654H03,AOB87749,BCP02118,EX-A2118,EXA2118,ZINC3962535,BDBM503568
77,NSC766887,NSC800811,s1220,AKOS026750567,BCP9001037,CCG-264867,CCG264867,CS,T2624,S1220,"OSI 930",OSI-930}

> <pdid>
PD003487

> <targets>
{"c-Kit | VEGFR-PDGFR",CSF-1R,VEGFR,c-Kit,Apoptosis,c-Fms}

> <classes>
{Protein Tyrosine Kinase,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{9868037}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 34  0  0  0  0            999 V2000
    5.0536    0.7860    0.0000 Cl  0  0
    7.6994    4.5206    0.0000 C   0  0
    6.1994    4.5163    0.0000 N   0  0
    5.3212    3.3003    0.0000 N   0  0
    3.8941    3.7597    0.0000 C   0  0
    2.5972    3.0060    0.0000 C   0  0
    1.2961    3.7523    0.0000 C   0  0
    1.2918    5.2523    0.0000 C   0  0
    2.5887    6.0060    0.0000 C   0  0
    3.8898    5.2597    0.0000 C   0  0
    5.3143    5.7273    0.0000 C   0  0
    5.7736    7.1552    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -0.0014    1.5008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 N   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -5.1977    2.9828    0.0000 N   0  0
   -5.1903    1.4820    0.0000 C   0  0
   -6.4841    0.7230    0.0000 C   0  0
   -6.4738   -0.7770    0.0000 C   0  0
   -5.1696   -1.5180    0.0000 C   0  0
   -5.1592   -3.0180    0.0000 C   0  0
   -3.8757   -0.7590    0.0000 C   0  0
   -3.8861    0.7409    0.0000 C   0  0
   -2.5708   -1.5004    0.0000 S   0  0
   -1.2773   -0.7410    0.0000 N   0  0
   -2.5595   -3.0004    0.0000 O   0  0
   -1.2663   -2.2408    0.0000 O   0  0
   -2.6005    2.9949    0.0000 N   0  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10  5  1  0
 10 11  2  0
 11  3  1  0
 11 12  1  0
  7 13  1  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 24 26  1  0
 26 27  2  0
 27 21  1  0
 26 28  1  0
 28 29  1  0
 28 30  2  0
 28 31  2  0
 19 32  2  0
 32 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28431

> <plate>
Kinase v5-2

> <well>
E15

> <supplier_cmpd_name>
Pazopanib Hydrochloride

> <ctcr_id>
5557

> <supplier_cmpd_id>
S1035

> <smiles>
Cl.Cn1nc2cc(ccc2c1C)N(C)c3ccnc(Nc4ccc(C)c(c4)[S](N)(=O)=O)n3

> <pd_targets>
{RET,ABL1,ABL2,JAK3,MAPK10,DDR2,LCK,EIF2AK2,PTK6,RAF1,MAP4K2,FGR,FYN,MYLK2,ROS1,STK36,PLK4,MAP2K4,EPHB6,FGFR3,MAP3K11,TXK,LIMK1,MAP3K10,CAMK1G,LIMK2,STK10,KIT,FLT4,FGFR1,FLT1,CDK16,PDGFRB,FRK,TNIK,MAP
K8,NEK2,DDR1,TGFBR2,KDR,MAP4K1,MAP4K3,BMP2K,MAP2K6,CDK11A,MAP3K9,LYN,FLT3,PI4KB,RIPK1,BLK,AURKC,SIK1,TIE1,ACHE,IGF1R,JAK2,GAK,RIOK2,ALK,FER,FGFR2,RIPK2,BRAF,CAMK1,NLK,TTK,PDGFRA,AAK1,ACVR2B,FGFR4,YES1
,MAP3K2,SYK,PTK2,EGFR,CSF1R,CDPK1,MERTK,STK16,MAP4K4,MAP4K5,CDK11B,PIP5K1C,PIP4K2C,MAP3K19,IRAK3,MET,BMPR1B,CDK7,TNK1,TAOK3,TAOK2,MAPK9,FES,HCK,TAOK1,LTK,IRAK1,TYK2,AURKA,TEK,MARK3,AURKB,MAP3K1,MAP2K5
,SRC,SRMS,SIK2,SLK,TNK2,NEK5,ABCB11,ABCC4,ITK,FGF1,SH2B3}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Transporter,"Secreted protein",Kinase,Transferase,Hydrolase,"Primary active transporter","Protein Kinase","ATP-binding cassette","TK protein kinase group","CMGC protein 
kinase group","Other protein kinase group","TKL protein kinase group","STE protein kinase group","CAMK protein kinase group","Atypical protein kinase group","ABCB subfamily","ABCC subfamily","Tyrosine
 protein kinase Ret family","Tyrosine protein kinase Abl family","Tyrosine protein kinase JakA family","CMGC protein kinase MAPK family","Tyrosine protein kinase DDR family","Tyrosine protein kinase S
rc family","Other protein kinase PEK family","TKL protein kinase RAF family","STE protein kinase STE20 family","CAMK protein kinase MLCK family","Tyrosine protein kinase Sev family","Other protein kin
ase ULK family","Other protein kinase PLK family","STE protein kinase STE7 family","Tyrosine protein kinase FGFR family","TKL protein kinase MLK family","Tyrosine protein kinase Tec family","TKL prote
in kinase LISK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","CMGC protein kinase CDK family","Other protein kinase NEK famil
y","TKL protein kinase STKR family","Other protein kinase NAK family","TKL protein kinase RIPK family","Other protein kinase AUR family","Tyrosine protein kinase Tie family","Tyrosine protein kinase I
nsR family","Atypical protein kinase RIO family","Tyrosine protein kinase Fer family","Other protein kinase TTK family","STE protein kinase STE11 family","Tyrosine protein kinase Syk family","Tyrosine
 protein kinase Fak family","Tyrosine protein kinase Axl family","TKL protein kinase IRAK family","Tyrosine protein kinase Met family","Tyrosine protein kinase Ack family","Tyrosine protein kinase Alk
 family","CMGC protein kinase JNK subfamily","Other protein kinase PKR","STE protein kinase KHS subfamily","Tyrosine protein kinase SrcA","TKL protein kinase MLK subfamily","TKL protein kinase LIMK su
bfamily","STE protein kinase SLK subfamily","CMGC protein kinase TAIRE subfamily","STE protein kinase MSN subfamily","TKL protein kinase STKR Type 2 subfamily","CMGC protein kinase PITSLRE subfamily",
"CAMK protein kinase QIK subfamily","Atypical protein kinase RIO2 subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase nmo subfamily","STE protein kinase MEKK2","CMGC protein kin
ase CDK7 subfamily","STE protein kinase TAO subfamily","CAMK protein kinase MARK subfamily","Tyrosine protein kinase Srm"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)","Acetylcholine turnover","ATP-binding cassette transporter family","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK
 families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Lipid modifying kinases",Atypical,"ABCB subfamily","ABCC subfamily
","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Other protein kinases","TKL: Tyrosine kinase-like","STE20 family","Myosin Light Chain Kinase (MLCK) family","STE7 family","CA
MK1 family","Cyclin-dependent kinase (CDK) family","1-phosphatidylinositol 4-kinase family","CAMK-like (CAMKL) family","RIO family","STE11 family","Type I PIP kinases (1-phosphatidylinositol-4-phospha
te 5-kinase family)","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","JNK subfamily","PEK family",
"RAF family","KHS subfamily","Unc-51-like kinase (ULK) family","Polo-like kinase (PLK) family","Mixed Lineage Kinase (MLK) family","LIM domain kinase (LISK) family","SLK subfamily","TAIRE subfamily","
MSN subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","Receptor serine/threonine kinase (RSTK) family","Numb-associated kinase (NAK) family","PITSLRE subfamily","Receptor intera
cting protein kinase (RIPK) family","Aurora kinase (Aur) family","QIK subfamily","RIO2 subfamily","nmo subfamily","TTK family","NAK family","STE20 subfamily","Interleukin-1 receptor-associated kinase 
(IRAK) family","CDK7 subfamily","TAO subfamily","MARK subfamily","Type XIV RTKs: RET","Abl family","Janus kinase (JakA) family","Type XVI RTKs: DDR (collagen receptor) family","Src family","Other PEK 
family kinases","Type XVII RTKs: ROS receptors","Type XIII RTKs: Ephrin receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","MLK subfamily","Tec family","LIMK subfamily","Ty
pe III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type II receptor serine/threonine kinases","Type XII RTKs: TIE family of 
angiopoietin receptors","Type II RTKs: Insulin receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Fer family","Syk family","Fak family","Type XI RTKs: TAM (TYRO3-","AXL
- and MER-TK) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type I receptor serine/threonine kinases","Ack family"}

> <pathway_reactome>
{"Developmental Biology",Disease,"Immune System","Extracellular matrix organization","Cell Cycle","Signal Transduction","Cellular responses to external stimuli","Gene expression (Transcription)",Metab
olism,"Circadian Clock","Vesicle-mediated transport","Metabolism of RNA","Neuronal System",Hemostasis,"Nervous system development","Infectious disease","Cytokine Signaling in Immune system","Innate Im
mune System","Non-integrin membrane-ECM interactions",Mitotic,"MAPK family signaling cascades","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor
 Tyrosine Kinases","Intracellular signaling by second messengers","Cellular responses to stress","RNA Polymerase II Transcription","Metabolism of lipids","Membrane Trafficking","rRNA processing","Tran
smission across Chemical Synapses","Signaling by WNT","Signaling by NODAL","Cell surface interactions at the vascular wall","Signaling by TGFB family members","Signaling by Non-Receptor Tyrosine Kinas
es","Platelet activation","signaling and aggregation","Adaptive Immune System","Axon guidance","Leishmania infection","Signaling by Interleukins","Toll-like Receptor Cascades","HIV Infection","Influen
za Infection","Mitotic G1 phase and G1/S transition","MAPK1/MAPK3 signaling","Mitotic G2-G2/M phases","Signaling by FGFR in disease","Oncogenic MAPK signaling","Fc epsilon receptor (FCERI) signaling",
"Neutrophil degranulation","Signaling by KIT in disease","Signaling by VEGF","PIP3 activates AKT signaling","Cellular Senescence","Regulation of mitotic cell cycle","Signaling by TGF-beta Receptor Com
plex in Cancer","Generic Transcription Pathway","Signaling by Insulin receptor","Phospholipid metabolism","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","trans-Golgi Network Vesic
le Budding","rRNA processing in the nucleus and cytosol","Signaling by SCF-KIT","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Beta-catenin independent WNT sig
naling","Signaling by PDGFR in disease","Clathrin-mediated endocytosis","Regulation of signaling by NODAL","Signaling by FGFR","Signaling by BMP","M Phase","Interferon Signaling","Signaling by PTK6","
Metabolism of steroids","Response to elevated platelet cytosolic Ca2+","TCR signaling","FLT3 Signaling","RET signaling","Parasite infection","Signaling by ROBO receptors","Interleukin-2 family signali
ng","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","NS1 Mediated Effects on Host Pathways","G1 Phase","RAF/MAP kinase cascade","Leishmania parasite growth and survival","G2/M
 Transition","EPH-Ephrin signaling","Signaling by FGFR3 in disease","Signaling by RAS mutants","FCERI mediated Ca+2 mobilization","Semaphorin interactions","Drug resistance of KIT mutants","VEGF ligan
d-receptor interactions","Signaling by FGFR1 in disease","Negative regulation of the PI3K/AKT network","PTEN Regulation","Oxidative Stress Induced Senescence","APC/C-mediated degradation of cell cycle
 proteins","Loss of Function of SMAD2/3 in Cancer","VEGFA-VEGFR2 Pathway","Transcriptional Regulation by TP53","Insulin receptor signalling cascade","PI Metabolism","Toll Like Receptor 4 (TLR4) Cascad
e","Transcriptional regulation by RUNX1","Glycerophospholipid biosynthesis","IGF1R signaling cascade","Golgi Associated Vesicle Biogenesis","Major pathway of rRNA processing in the nucleolus and cytos
ol","Signaling by FGFR2 in disease","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","Ca2+ pathway","Drug resistance of PDGFR mutants","Cargo recognition for clathrin
-mediated endocytosis","Signaling by FGFR4","Transcriptional Regulation by VENTX","Toll Like Receptor 2 (TLR2) Cascade","HIV Life Cycle","Mitotic Metaphase and Anaphase","Interferon alpha/beta signali
ng","PTK6 Down-Regulation","Bile acid and bile salt metabolism","Platelet degranulation","Generation of second messenger molecules","Negative regulation of FLT3","Leishmania phagocytosis","Role of ABL
 in ROBO-SLIT signaling","Interleukin-15 signaling","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Inhibition of PKR","Cyclin D associate
d events in G1","Negative regulation of MAPK pathway","Anti-inflammatory response favouring Leishmania parasite infection","Centrosome maturation","EPHB-mediated forward signaling","Signaling by FGFR3
 point mutants in cancer","Signaling downstream of RAS mutants","Sema4D in semaphorin signaling","Dasatinib-resistant KIT mutants","VEGF binds to VEGFR leading to receptor dimerization","FGFR1 mutant 
receptor activation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Regulation of PTEN stability and activity","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","SMAD2/
3 Phosphorylation Motif Mutants in Cancer","VEGFR2 mediated cell proliferation","Regulation of TP53 Activity","IRS-mediated signalling","Synthesis of PIPs at the Golgi membrane","MyD88-independent TLR
4 cascade","RUNX1 regulates transcription of genes involved in BCR signaling","Synthesis of PC","IRS-related events triggered by IGF1R","FGFR2 mutant receptor activation","Signalling to ERKs","Post NM
DA receptor activation events","Imatinib-resistant PDGFR mutants","Downstream signaling of activated FGFR4","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Toll Like Receptor TLR6
:TLR2 Cascade","Late Phase of HIV Life Cycle","CRMPs in Sema3A signaling","Mitotic Anaphase","Regulation of IFNA signaling","Signalling to ERK5","Synthesis of bile acids and bile salts","FCGR3A-mediat
ed phagocytosis","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Negative feedback regulation of MAPK pathway","FCGR3A-mediate
d IL10 synthesis","Nef and signal transduction","Loss of proteins required for interphase microtubule organization from the centrosome","FGFR3 mutant receptor activation","Sema4D induced cell migratio
n and growth-cone collapse","Signaling by activated point mutants of FGFR1","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Acetylation","Recruitment of mit
otic centrosome proteins and complexes","PI3K Cascade","TRIF(TICAM1)-mediated TLR4 signaling","Activated point mutants of FGFR2","Prolonged ERK activation events","Activation of RAC1 downstream of NMD
ARs","FRS-mediated FGFR4 signaling","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Sema4D mediated inhibition of cell attachment and migration","Transcription of the HIV genome","Separation 
of Sister Chromatids","Regulation of TP53 Activity through Phosphorylation","Signalling to RAS","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","MAPK targets/ Nuclear events med
iated by MAP kinases","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","Signaling by act
ivated point mutants of FGFR3","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","PI5P Regulates TP53 Acetylation","IKK complex recruitment medi
ated by RIP1","activated TAK1 mediates p38 MAPK activation","ARMS-mediated activation","HIV Transcription Elongation","p38MAPK events","Activation of the AP-1 family of transcription factors","APC-Cdc
20 mediated degradation of Nek2A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{CSF1R,FGF1,FGFR1,FGFR3,FLT1,FLT4,ITK,KDR,KIT,PDGFRA,PDGFRB,SH2B3}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{AKOS015918055,"Pazopanib hydrochloride",635702-64-6,635702646,"635702 64 6","pazopanib HCl",Votrient,"Pazopanib (Hydrochloride)",UNII-33Y9ANM545,UNII33Y9ANM545,"UNII 33Y9ANM545","Pazopanib HCl (GW786
034 HCl)",GW786034B,pazopanib,737754,S1035,"NSC 737754","Pazopanib Hydrochloride"}

> <pdid>
PD003339

> <targets>
{VEGFR,VEGFR-PDGFR,Autophagy,c-Kit,FGFR,PDGFR,c-Fms}

> <classes>
{Tyrosine kinase inhibitor,Autophagy,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{46864002,11525740}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 34  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 O   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 C   0  0
   -5.2112    5.9836    0.0000 N   0  0
   -6.5072    5.2269    0.0000 C   0  0
   -6.4994    3.7269    0.0000 O   0  0
   -7.8111    5.9701    0.0000 N   0  0
   -9.1072    5.2134    0.0000 C   0  0
  -10.4114    5.9543    0.0000 C   0  0
  -11.7053    5.1953    0.0000 C   0  0
  -11.6949    3.6953    0.0000 C   0  0
  -12.9887    2.9364    0.0000 Cl  0  0
  -10.3907    2.9543    0.0000 C   0  0
   -9.0969    3.7133    0.0000 C   0  0
  -10.3803    1.4536    0.0000 C   0  0
  -11.6736    0.6938    0.0000 F   0  0
   -9.0759    0.7130    0.0000 F   0  0
  -10.3692   -0.0464    0.0000 F   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 22 23  2  0
 23 17  1  0
 22 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
 12 28  1  0
 28 29  2  0
 29  9  1  0
  7 30  2  0
 30 31  1  0
 31 32  2  0
 32  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28432

> <plate>
Kinase v5-2

> <well>
E17

> <supplier_cmpd_name>
Sorafenib Tosylate

> <ctcr_id>
6031

> <supplier_cmpd_id>
S1040

> <smiles>
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1

> <pd_targets>
{EPHA6,RAF1,MKNK2,EPHA5,FLT4,FLT3,MAPK12,HTR7,BRAF,CSF1R,CDK17,CDK14,AURKA,AXL,CAMK2B,RET,FGR,MAP2K5,ARAF,KDR,CDK8,KIT,MAPK14,FRK,EPHA8,ABL2,EPHA4,SLK,FGFR1,RIPK2,NTRK1,STK36,LCK,MAPK13,STK33,TNNI3K,D
DR2,LYN,AURKC,TAOK3,PDGFRB,MYLK3,ABL1,STK10,CLK1,TTK,MAPK15,CIT,TEK,HTR6,CDK7,SRMS,MINK1,KMT2A,MEN1,FGFR2,EPHA2,FGFR3,TAOK1,CDK19,DDR1,EPHB4,FLT1,MYLK2,CDK2,HIPK2,MAPK11,EPHA7,MAP4K5,LIMK1,MAPK9,HIPK4
,EPHA3,MKNK1,SRPK1,TNK1,AURKB,CDKL2,CDKL3,HIPK1,CCNC,MAPK1,EGFR,TGFBR2,HTR2B,CDK5,MAP3K20,MAP4K4,PDGFRA,TIE1,RPS6KA6,FYN,EPHB1,EPHB2,NTRK2,TNIK,NTRK3,MUSK,HIPK3,EPHA1,IRAK1,RORC,MERTK,EPHB6,NLK,MAPK3,
DYRK3,CDK3,NTSR1,RPS6KB1,PLK2,MAP3K7,LIMK2,HCK,HTR2C,CDK15,HTR2A,EPHX2,PLK4,MAP4K1,CDPK1,HTR5A,MYO3B,ABCB11,CSNK1A1,MAP3K19,MET,TAOK2,CSK,JAK3,BLK,RIPK1,CCNA2,HTR1A,SRC,GSK3B,INSR,CA7,CYP19A1,MAP2K1,R
IPK3,PAX8,LMP1,MC4R}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Epigenetic regulator","Transcription factor","Unclassified protein",Transporter,Kinase,"Family A G protein-coupled receptor",Reader,"Nuclear receptor",Protease,"Primary ac
tive transporter",Lyase,"Cytochrome P450","Protein Kinase","Small molecule receptor (family A GPCR)",Bromodomain,"Nuclear hormone receptor subfamily 1","Peptide receptor (family A GPCR)","Serine prote
ase","ATP-binding cassette","Cytochrome P450 family 19","TK protein kinase group","TKL protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Monoamine receptor","Other protein
 kinase group","STE protein kinase group","AGC protein kinase group","Nuclear hormone receptor subfamily 1 group F","Short peptide receptor (family A GPCR)","Serine protease SC clan","ABCB subfamily",
"CK1 protein kinase group","Cytochrome P450 family 19A","Tyrosine protein kinase Eph family","TKL protein kinase RAF family","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase VEGFR family"
,"Tyrosine protein kinase PDGFR family","CMGC protein kinase MAPK family","Serotonin receptor","CMGC protein kinase CDK family","Other protein kinase AUR family","Tyrosine protein kinase Axl family","
CAMK protein kinase CAMK2 family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Src family","STE protein kinase STE7 family","Tyrosine protein kinase Abl family","STE protein kinase ST
E20 family","Tyrosine protein kinase FGFR family","TKL protein kinase RIPK family","Tyrosine protein kinase Trk family","Other protein kinase ULK family","CAMK protein kinase unique family","TKL prote
in kinase MLK family","Tyrosine protein kinase DDR family","CAMK protein kinase MLCK family","CMGC protein kinase CLK family","Other protein kinase TTK family","AGC protein kinase DMPK family","Tyrosi
ne protein kinase Tie family","CMGC protein kinase DYRK family","TKL protein kinase LISK family","CMGC protein kinase SRPK family","Tyrosine protein kinase Ack family","CMGC protein kinase CDKL family
","Tyrosine protein kinase EGFR family","TKL protein kinase STKR family","AGC protein kinase RSK family","Tyrosine protein kinase Musk family","TKL protein kinase IRAK family","Nuclear hormone recepto
r subfamily 1 group F member 3","Neurotensin receptor","Other protein kinase PLK family","Serine protease S33 family","CK1 protein kinase CK1 family","STE protein kinase STE11 family","Tyrosine protei
n kinase Met family","Tyrosine protein kinase Csk family","Tyrosine protein kinase JakA family","CMGC protein kinase GSK family","Tyrosine protein kinase InsR family","Cytochrome P450 19A1","Melanocor
tin receptor","CAMK protein kinase MNK subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase PCTAIRE","CMGC protein kinase PFTAIRE","CMGC protein kinase CDK8 subfamily","STE protein kina
se SLK subfamily","TKL protein kinase HH498 subfamily","STE protein kinase TAO subfamily","AGC protein kinase CRIK subfamily","CMGC protein kinase CDK7 subfamily","Tyrosine protein kinase Srm","STE pr
otein kinase MSN subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase KHS subfamily","TKL protein kinase LIMK subfamily","CMGC protein kinase JNK su
bfamily","CMGC protein kinase ERK1","TKL protein kinase STKR Type 2 subfamily","CMGC protein kinase CDK5 subfamily","TKL protein kinase MLK subfamily","AGC protein kinase RSK subfamily","Tyrosine prot
ein kinase SrcA","CMGC protein kinase nmo subfamily","CMGC protein kinase Dyrk2 subfamily","AGC protein kinase p70 subfamily","Other protein kinase PLK2","TKL protein kinase TAK1 subfamily","STE prote
in kinase NinaC subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)","G protein-coupled receptors","Nuclear hormone receptors",Hydrolases,"ATP-binding cassette transporter family","Carbonic an
hydrases","Cytochrome P450","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","5-Hydroxytryptamine receptors","STE: Homologs of ye
ast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","1F. Retinoic acid-related orphans","Neurotensin receptors","ABCB subfamily","CK1: Casein kinase 1",CYP11,CYP1
7,CYP19,"CYP20 and CYP21 families","Melanocortin receptors","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","Mitogen-activated protein kinases (MAP k
inases)","Cyclin-dependent kinase (CDK) family","Other protein kinases","CAMK2 family","STE7 family","STE20 family","CAMK-unique family","Myosin Light Chain Kinase (MLCK) family","CLK family","DMPK fa
mily","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","SRPK family","Cyclin-dependent kinase-like (CDKL) family","RSK family","Casein kinase 1 (CK1) family","Glycogen sy
nthase kinase (GSK) family","Receptor tyrosine kinases (RTKs)","RAF family","MKN subfamily","p38 subfamily","TAIRE subfamily","Aurora kinase (Aur) family","Non-receptor tyrosine kinases (nRTKs)","CDK8
 subfamily","SLK subfamily","Receptor interacting protein kinase (RIPK) family","Unc-51-like kinase (ULK) family","Mixed Lineage Kinase (MLK) family","TAO subfamily","TTK family","Erk7 subfamily","Oth
er DMPK family kinases","CDK7 subfamily","MSN subfamily","CDK1 subfamily","HIPK subfamily","KHS subfamily","LIM domain kinase (LISK) family","JNK subfamily","ERK subfamily","Receptor serine/threonine 
kinase (RSTK) family","CDK5 subfamily","RSK subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","nmo subfamily","Dyrk2 subfamily","p70 subfamily","Polo-like kinase (PLK) family","NinaC
 subfamily","STE20 subfamily","GSK subfamily","Type XIII RTKs: Ephrin receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 r
eceptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type XIV RTKs: RET","Src family","Abl family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type VII RT
Ks: Neurotrophin receptor/Trk family","HH498 subfamily","Type XVI RTKs: DDR (collagen receptor) family","Type XII RTKs: TIE family of angiopoietin receptors","LIMK subfamily","Ack family","Type I RTKs
: ErbB (epidermal growth factor) receptor family","Type II receptor serine/threonine kinases","MLK subfamily","Type IX RTKs: MuSK","TAK1 subfamily","Type X RTKs: HGF (hepatocyte growth factor) recepto
r family","Csk family","Janus kinase (JakA) family","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction",Disease,"Gene expression (Transcription)","Neuronal System","Immune System","Extracellular matrix organization","Cellular responses to external stimuli",
"Cell Cycle",Metabolism,Hemostasis,"Nervous system development","MAPK family signaling cascades","Signaling by Receptor Tyrosine Kinases","Infectious disease","RNA Polymerase II Transcription","Transm
ission across Chemical Synapses","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System","Intracellular signaling by second messengers","Non-integrin 
membrane-ECM interactions","Signaling by Rho GTPases","Signaling by Non-Receptor Tyrosine Kinases","Cellular responses to stress",Mitotic,"Metabolism of lipids","Signaling by GPCR","ECM proteoglycans"
,"Cell surface interactions at the vascular wall","Signaling by WNT","MTOR signalling","Cytokine Signaling in Immune system","Reversible hydration of carbon dioxide","Biological oxidations","Axon guid
ance","MAPK1/MAPK3 signaling","Signaling by VEGF","Signaling by Insulin receptor","Signaling by NTRKs","Leishmania infection","Generic Transcription Pathway","Neurotransmitter receptors and postsynapt
ic signal transmission","Oncogenic MAPK signaling","Signaling by NOTCH1 in Cancer","Signaling by KIT in disease","Toll-like Receptor Cascades","PIP3 activates AKT signaling","Signaling by FGFR in dise
ase","HIV Infection","Neutrophil degranulation","RHO GTPase Effectors","Signaling by PTK6","Cellular Senescence","M Phase","Regulation of lipid metabolism by PPARalpha","Signaling by FGFR","GPCR downs
tream signalling","Signaling by TGF-beta Receptor Complex in Cancer","GPCR ligand binding","Signaling by PDGFR in disease","Beta-catenin independent WNT signaling","mTORC1-mediated signalling","Biosyn
thesis of specialized proresolving mediators (SPMs)","Mitotic G2-G2/M phases","Metabolism of steroids","Signaling by WNT in cancer","Signaling by Interleukins","SARS-CoV Infections","Phase I - Functio
nalization of compounds","EPH-Ephrin signaling","RAF/MAP kinase cascade","VEGF ligand-receptor interactions","Insulin receptor signalling cascade","Signaling by NTRK1 (TRKA)","Leishmania parasite grow
th and survival","Transcriptional Regulation by VENTX","Transcriptional Regulation by TP53","VEGFA-VEGFR2 Pathway","Activation of NMDA receptors and postsynaptic events","RET signaling","Signaling by 
RAS mutants","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Drug resistance of KIT mutants","Toll Like Receptor 5 (TLR5) Cascade","PTEN Regulation","Signaling by ROBO receptors","Signaling by
 FGFR1 in disease","Host Interactions of HIV factors","Negative regulation of the PI3K/AKT network","Parasite infection","RHO GTPases activate CIT","HIV Life Cycle","PTK6 Down-Regulation","Oxidative S
tress Induced Senescence","Signaling by FGFR2 in disease","Signaling by FGFR3 in disease","Mitotic Metaphase and Anaphase","PPARA activates gene expression","Semaphorin interactions","Signaling by FGF
R4","G alpha (q) signalling events","Loss of Function of SMAD2/3 in Cancer","Class A/1 (Rhodopsin-like receptors)","Drug resistance of PDGFR mutants","Signaling by NTRK3 (TRKC)","Transcriptional regul
ation by RUNX3","Ca2+ pathway","Toll Like Receptor 4 (TLR4) Cascade","Biosynthesis of DHA-derived SPMs","G2/M Transition","Bile acid and bile salt metabolism","Signaling by AMER1 mutants","Interleukin
-2 family signaling","Transcriptional regulation by RUNX1","SARS-CoV-1 Infection","Cytochrome P450 - arranged by substrate type","EPHA-mediated growth cone collapse","Negative regulation of MAPK pathw
ay","VEGF binds to VEGFR leading to receptor dimerization","IRS-mediated signalling","Signalling to ERKs","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of TP53 Activ
ity","Post NMDA receptor activation events","Signalling to ERK5","Signaling downstream of RAS mutants","VEGFR2 mediated cell proliferation","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","D
asatinib-resistant KIT mutants","MyD88 cascade initiated on plasma membrane","Regulation of PTEN stability and activity","Role of ABL in ROBO-SLIT signaling","FGFR1 mutant receptor activation","The ro
le of Nef in HIV-1 replication and disease pathogenesis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Leishmania phagocytosis","Late Phase of HIV Life Cycle","FGFR2 mutant receptor activation","S
ignaling by FGFR3 point mutants in cancer","Mitotic Anaphase","EPHB-mediated forward signaling","Sema4D in semaphorin signaling","Negative regulation of FGFR4 signaling","Gastrin-CREB signalling pathw
ay via PKC and MAPK","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Amine ligand-binding receptors","Imatinib-resistant PDGFR mutants","Activation of TRKA receptors","Activated NTRK3 signals throu
gh PI3K","RUNX3 Regulates Immune Response and Cell Migration","Peptide ligand-binding receptors","MyD88-independent TLR4 cascade","Biosynthesis of maresins","Centrosome maturation","Synthesis of bile 
acids and bile salts","Truncations of AMER1 destabilize the destruction complex","Interleukin-15 signaling","RUNX1 regulates transcription of genes involved in BCR signaling","SARS-CoV-1 Genome Replic
ation and Transcription","Endogenous sterols","Negative feedback regulation of MAPK pathway","PI3K Cascade","Signalling to RAS","ADORA2B mediated anti-inflammatory cytokines production","Prolonged ERK
 activation events","Regulation of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","FCGR3A-mediated IL10 synthesis","MAP kinas
e activation","Signaling by activated point mutants of FGFR1","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated phagocytosis","Transcrip
tion of the HIV genome","Activated point mutants of FGFR2","FGFR3 mutant receptor activation","Separation of Sister Chromatids","Regulation of TP53 Expression and Degradation","Sema4D induced cell mig
ration and growth-cone collapse","Spry regulation of FGF signaling","EGFR Transactivation by Gastrin","Serotonin receptors","Nef and signal transduction","NGF-independant TRKA activation","CD163 media
ting an anti-inflammatory response","TRIF(TICAM1)-mediated TLR4 signaling","Loss of proteins required for interphase microtubule organization from the centrosome","Synthesis of bile acids and bile sal
ts via 7alpha-hydroxycholesterol","Sema4D mediated inhibition of cell attachment and migration","Replication of the SARS-CoV-1 genome","p38MAPK events","ARMS-mediated activation","Ras activation upon 
Ca2+ influx through NMDA receptor","MAPK targets/ Nuclear events mediated by MAP kinases","activated TAK1 mediates p38 MAPK activation","Nef Mediated CD4 Down-regulation","HIV Transcription Elongation
","Signaling by activated point mutants of FGFR3","Regulation of TP53 Degradation","RSK activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Loss of Nlp from mitotic centrosomes
","IKK complex recruitment mediated by RIP1","Activation of the AP-1 family of transcription factors","Tat-mediated elongation of the HIV-1 transcript","ERK/MAPK targets","Formation of HIV-1 elongatio
n complex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
{BRAF,DDR2,FGFR1,FLT1,FLT3,FLT4,KDR,KIT,PDGFRB,RAF1,RET}

> <broad_moa>
{"FLT3 inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","RAF inhibitor","RET tyrosine kinase inhibitor","VEGFR inhibitor"}

> <synonyms>
{"AY 43900",Sorafenib,284461-73-0,284461730,Nexavar,"BAY 43-9006","BAY 439006",UNII-9ZOQ3TZI87,UNII9ZOQ3TZI87,"Sorafenib free base","284461-73-0 (free base)","284461730 (free base)",100012-18-8,100012
188,BAY-43-9006,BAY439006,9ZOQ3TZI87,CHEMBL1336,DTXSID7041128,CHEBI:50924,MFCD06411450,"Sorafenib (Nexavar)","Donafenib (Sorafenib D3)",T0093L,747971,10009644,S7397,"NSC 747971",sorafenib,"Sorafenib T
osylate",SORAFENIB,"Sorafenib tosylate"}

> <pdid>
PD003493

> <targets>
{B-Raf,PDGFR,Raf,RAF,KIT,VEGFR2/3,Apoptosis,Autophagy,Ferroptosis,FLT3,VEGFR}

> <classes>
{Raf/PDGF/VEGFR inhibitor,Apoptosis,Autophagy,MAPK/ERK Pathway,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{216239}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 39  0  0  0  0            999 V2000
   -6.4717  -14.5676    0.0000 C   0  0
   -6.0099  -13.1405    0.0000 C   0  0
   -4.5425  -12.8257    0.0000 N   0  0
   -3.5342  -13.9374    0.0000 C   0  0
   -2.0679  -13.6212    0.0000 C   0  0
   -4.0804  -11.3978    0.0000 C   0  0
   -2.6130  -11.0830    0.0000 C   0  0
   -2.1509   -9.6551    0.0000 N   0  0
   -0.6835   -9.3403    0.0000 C   0  0
    0.3219  -10.4535    0.0000 O   0  0
   -0.2222   -7.9149    0.0000 C   0  0
    1.2028   -7.4466    0.0000 C   0  0
    2.4192   -8.3243    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6079   -6.7003    0.0000 C   0  0
    8.9536   -4.6590    0.0000 O   0  0
    8.9536   -6.1590    0.0000 C   0  0
    7.6536   -6.9090    0.0000 C   0  0
    6.3536   -6.1590    0.0000 C   0  0
    6.3536   -4.6590    0.0000 O   0  0
    5.0543   -6.9086    0.0000 O   0  0
   10.2536   -6.9090    0.0000 C   0  0
   10.2536   -8.4090    0.0000 O   0  0
   11.5529   -6.1594    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 24 26  1  0
 26 27  2  0
 27 17  1  0
 27 21  1  0
 15 28  2  0
 28 11  1  0
 28 29  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 33 35  2  0
 31 36  1  0
 36 37  1  0
 36 38  2  0
M  END
> <name>
UTKinase_V5

> <id>
28433

> <plate>
Kinase v5-2

> <well>
E19

> <supplier_cmpd_name>
Sunitinib Malate

> <ctcr_id>
5297

> <supplier_cmpd_id>
S1042

> <smiles>
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc23)c1C.OC(CC(O)=O)C(O)=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HMS3244A19,HMS3244A20,HMS3244B19,HMS3295O05,HMS3654M09,BCP01768,"341031-54-7 (malate)","341031547 (malate)",ANW-43713,ANW43713,AK544273,DB-011547,DB011547,"SU 11248 Malate;SU11248 Malate;SU-11248 Mal
ate","SU 11248 Malate;SU11248 Malate;SU11248 Malate",S1042,"Sunitinib Malate"}

> <pdid>

> <targets>
{VEGFR-PDGFR,VEGFR,c-Kit,PDGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{53394000}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    2.4192   -8.3243    0.0000 C   0  0
    1.2028   -7.4466    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6079   -6.7003    0.0000 C   0  0
   -0.2222   -7.9149    0.0000 C   0  0
   -0.6776   -9.3422    0.0000 C   0  0
    0.3320  -10.4528    0.0000 C   0  0
   -0.1241  -11.8826    0.0000 C   0  0
   -1.5898  -12.2019    0.0000 O   0  0
    0.8848  -12.9926    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  2  0
 16 17  1  0
 16 18  1  0
 18  2  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 21 23  2  0
M  END
> <name>
UTKinase_V5

> <id>
28434

> <plate>
Kinase v5-2

> <well>
E21

> <supplier_cmpd_name>
TSU-68

> <ctcr_id>
6269

> <supplier_cmpd_id>
S1470

> <smiles>
Cc1[nH]c(C=C2C(=O)Nc3ccccc23)c(C)c1CCC(O)=O

> <pd_targets>
{FGFR1,PDGFRB,AURKB,KDR,FLT1,EGFR,AURKC,ZAP70,PDGFRA,FGFR2,FGFR3,FGFR4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family","Other protein kinase AUR family","T
yrosine protein kinase VEGFR family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Syk family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kinases (RTKs)","Aurora kinase (Aur) family","Non-receptor tyrosine kinases (nRTKs)
","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type I
 RTKs: ErbB (epidermal growth factor) receptor family","Syk family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Cell Cycle","Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Intracellular signaling by second messengers",Mitotic,"S
ignaling by Receptor Tyrosine Kinases","Signaling by GPCR","Adaptive Immune System","Signaling by FGFR in disease","PIP3 activates AKT signaling","M Phase","Signaling by VEGF","GPCR downstream signall
ing","TCR signaling","Signaling by FGFR1 in disease","Negative regulation of the PI3K/AKT network","Mitotic Metaphase and Anaphase","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","G alpha 
(q) signalling events","Generation of second messenger molecules","FGFR1 mutant receptor activation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Mitotic Anaphase","VEGFR2 mediated cell prolifera
tion","VEGF binds to VEGFR leading to receptor dimerization","Gastrin-CREB signalling pathway via PKC and MAPK","Signaling by activated point mutants of FGFR1","Separation of Sister Chromatids","EGFR 
Transactivation by Gastrin"}

> <broad_targets>
{AURKA,AURKB,EGFR,FGFR1,FGFR2,KDR,PDGFRA,PDGFRB}

> <broad_moa>
{"FGFR inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{252916-29-3,252916293,210644-62-5,210644625,"3-(4-(2-Carboxyethyl)-3,5-dimethylpyrrol-2-methylidenyl)-2-indolinone","3(4(2Carboxyethyl)3,5dimethylpyrrol2methylidenyl)2indolinone",Kinome_2849,Kinome28
49,Kinome-2849,"Kinome 2849",CHEMBL2007064,CHEBI:91088,HMS3244A17,HMS3244A18,HMS3244B17,HMS3654J12,BCP01984,NCGC00241113-01,NCGC0024111301,AK109508,NCI60_036760,NCI60036760,NCI60-036760,"NCI60 036760"
,T6184,S1470,Orantinib,TSU-68,"TSU-68 (SU6668, Orantinib)"}

> <pdid>
PD011179

> <targets>
{VEGFR-PDGFR,VEGFR,FGFR,PDGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{206042}

$$$$
UTKinase_V5
  SciTegic11012413002D

 46 51  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2982    3.7531    0.0000 O   0  0
    1.2960    5.2539    0.0000 C   0  0
   -0.0056    5.9995    0.0000 C   0  0
   -0.0108    7.4995    0.0000 C   0  0
    1.2856    8.2540    0.0000 C   0  0
    1.2835    9.7548    0.0000 N   0  0
    2.5817   10.5079    0.0000 C   0  0
    3.8821    9.7601    0.0000 O   0  0
    2.5796   12.0087    0.0000 C   0  0
    1.9430   13.2402    0.0000 C   0  0
    1.1951   11.9400    0.0000 C   0  0
    3.8784   12.7616    0.0000 C   0  0
    5.1785   12.0134    0.0000 O   0  0
    3.8768   14.2624    0.0000 N   0  0
    5.1752   15.0151    0.0000 C   0  0
    5.1758   16.5151    0.0000 C   0  0
    6.4751   17.2647    0.0000 C   0  0
    7.7739   16.5143    0.0000 C   0  0
    9.0732   17.2639    0.0000 F   0  0
    7.7734   15.0143    0.0000 C   0  0
    6.4741   14.2647    0.0000 C   0  0
    2.5873    7.5085    0.0000 C   0  0
    2.5924    6.0085    0.0000 C   0  0
    3.8941    5.2631    0.0000 F   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 N   0  0
   -3.9099   -8.2497    0.0000 C   0  0
   -3.9099   -9.7497    0.0000 C   0  0
   -2.6109  -10.4997    0.0000 O   0  0
   -1.3119   -9.7497    0.0000 C   0  0
   -1.3118   -8.2497    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 15  1  0
 15 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 24 26  1  0
 26 27  2  0
 27 21  1  0
 11 28  1  0
 28 29  2  0
 29  8  1  0
 29 30  1  0
  6 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34  5  1  0
 34 35  1  0
 35 36  2  0
 36  3  1  0
 36 37  1  0
 37 38  1  0
 38 39  1  0
 39 40  1  0
 40 41  1  0
 41 42  1  0
 42 43  1  0
 43 44  1  0
 44 45  1  0
 45 46  1  0
 46 41  1  0
M  END
> <name>
UTKinase_V5

> <id>
28435

> <plate>
Kinase v5-2

> <well>
G03

> <supplier_cmpd_name>
XL880(GSK1363089)

> <ctcr_id>
2909

> <supplier_cmpd_id>
S1111

> <smiles>
COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc5ccc(F)cc5)cc3F)ccnc2cc1OCCCN6CCOCC6

> <pd_targets>
{PTK2B,MAP3K9,STK35,MAP2K5,HIPK1,FYN,TEC,TYK2,CDK13,DDR2,EPHA1,EPHA3,YES1,HIPK3,MAP3K12,CDK14,CDK9,CSNK1E,ERBB3,MAP3K10,FGFR1,CDK11B,MAPK9,HIPK4,CAMKK1,NEK9,MET,BMX,DDR1,KDR,MST1R,STK33,FLT3,EPHB4,MAP
3K13,FGFR3,INSR,KIT,ABL1,EGFR,FGR,TIE1,ITK,PTK6,CDK16,PDGFRA,STK4,TESK1,MAP4K5,INSRR,TAOK2,PRKAA1,FLT1,FLT4,PDGFRB,ROS1,ERBB2,MINK1,ERBB4,MAP4K1,EPHA6,MKNK1,MAP3K11,MAPK13,CDKL5,AURKA,CDC42BPA,RIPK1,R
IPK2,CDKL2,TNK1,EPHA4,JAK2,AXL,TEK,MAPK8,DYRK2,MAP4K3,EPHB6,SMO,CLK1,NTRK3,CSF1R,MAK,NTRK2,PLK4,TNIK,CDC42BPG,AURKC,AURKB,BTK,FER,LIMK2,MUSK,MAP3K4,PRKAA2,CAMKK2,HUNK,CHEK2,CDK8,CDK7,RET,RIPK4,FGFR2,P
IP4K2C,SRMS,MAP3K20,MAPK14,ULK3,MAP3K3,MAP2K2,SIK1,CDK18,MAP2K1,RAF1,RPS6KB1,ALK,BRAF,CSK,MAPK12,MERTK,ABL2,PRKD3,TYRO3,CIT,TBK1,EIF2AK1,SLK,MYO3A,MKNK2,TXK,CAMK1,EPHA2,MAP4K2,ROCK2,CDKL3,DAPK3,BLK,FE
S,CAMK1D,EPHA8,TAOK1,MYLK2,MAP3K7,LTK,STK25,STK36,PAK3,MAPK10,TTK,EPHB3,IGF1R,RPS6KA2,MYO3B,LIMK1,LYN,CLK4,CDK11A,MAP3K19,CDK15,MAP4K4,EPHA5,CDPK1,LCK,SRC,STK10,MAP3K2,IRAK3,IKBKE,CDK19,SIK2,TNNI3K,NL
K,EPHB2,TNK2,NTRK1,CHUK,CSNK2A2,FRK,HCK,HIPK2,MAPK15,PTK2,ANKK1,MYLK3,DSTYK,MAPK11,SYK,EPHA7,EPHB1,CDK17,CDC42BPB,MELK}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Membrane receptor",Kinase,"Frizzled family G protein-coupled receptor",Transferase,"Protein Kinase","Smoothened receptor (frizzled family GPCR)","TK protein kinase grou
p","TKL protein kinase group","Other protein kinase group","STE protein kinase group","CMGC protein kinase group","CK1 protein kinase group","CAMK protein kinase group","AGC protein kinase group","Tyr
osine protein kinase Fak family","TKL protein kinase MLK family","Other protein kinase NKF4 family","STE protein kinase STE7 family","CMGC protein kinase DYRK family","Tyrosine protein kinase Src fami
ly","Tyrosine protein kinase Tec family","Tyrosine protein kinase JakA family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Eph family","CMGC protein kinase CDK family","CK1 protein k
inase CK1 family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase FGFR family","CMGC protein kinase MAPK family","Other protein kinase CAMKK family","Other protein kinase NEK family","T
yrosine protein kinase Met family","Tyrosine protein kinase VEGFR family","CAMK protein kinase unique family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase InsR family","Tyrosine pro
tein kinase Abl family","Tyrosine protein kinase Tie family","STE protein kinase STE20 family","TKL protein kinase LISK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Sev family",
"CAMK protein kinase MAPKAPK family","CMGC protein kinase CDKL family","Other protein kinase AUR family","AGC protein kinase DMPK family","TKL protein kinase RIPK family","Tyrosine protein kinase Ack 
family","Tyrosine protein kinase Axl family","CMGC protein kinase CLK family","Tyrosine protein kinase Trk family","CMGC protein kinase RCK family","Other protein kinase PLK family","Tyrosine protein 
kinase Fer family","Tyrosine protein kinase Musk family","STE protein kinase STE11 family","CAMK protein kinase RAD53 family","Tyrosine protein kinase Ret family","Other protein kinase ULK family","TK
L protein kinase RAF family","AGC protein kinase RSK family","TKL protein kinase STKR family","Tyrosine protein kinase Csk family","CAMK protein kinase PKD family","Other protein kinase IKK family","O
ther protein kinase PEK family","CAMK protein kinase DAPK family","CAMK protein kinase MLCK family","Tyrosine protein kinase Alk family","Other protein kinase TTK family","TKL protein kinase IRAK fami
ly","Other protein kinase CK2 family","Tyrosine protein kinase Syk family","TKL protein kinase MLK subfamily","CMGC protein kinase HIPK subfamily","Tyrosine protein kinase SrcA","CMGC protein kinase P
FTAIRE","CMGC protein kinase CDK9 subfamily","CMGC protein kinase PITSLRE subfamily","CMGC protein kinase JNK subfamily","Other protein kinase Meta subfamily","TKL protein kinase LZK subfamily","CMGC 
protein kinase TAIRE subfamily","STE protein kinase MST subfamily","TKL protein kinase TESK subfamily","STE protein kinase KHS subfamily","STE protein kinase TAO subfamily","CAMK protein kinase AMPK s
ubfamily","STE protein kinase MSN subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase p38 subfamily","AGC protein kinase GEK subfamily","CMGC protein kinase Dyrk2 subfamily","CMGC prot
ein kinase MAK","TKL protein kinase LIMK subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase CDK7 subfamily","Tyrosine protein kinase Srm","STE protein kinase MEKK2","CAMK protein kin
ase QIK subfamily","CMGC protein kinase PCTAIRE","AGC protein kinase p70 subfamily","TKL protein kinase STKR Type 1 subfamily","AGC protein kinase CRIK subfamily","Other protein kinase HRI","STE prote
in kinase SLK subfamily","STE protein kinase NinaC subfamily","AGC protein kinase ROCK subfamily","TKL protein kinase TAK1 subfamily","STE protein kinase YSK subfamily","STE protein kinase PAKA subfam
ily","AGC protein kinase RSK subfamily","TKL protein kinase HH498 subfamily","CMGC protein kinase nmo subfamily","CAMK protein kinase MELK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","G protein-coupled receptors","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing 
CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC families","Class Frizzled GPCRs","Lipid modifying kinases","TK:
 Tyrosine kinase","TKL: Tyrosine kinase-like","Other protein kinases","STE7 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Cyclin-dependent kinase (CDK) family
","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","CAMK-unique family","STE20 family","CAMK-like (CAMKL) family","MAPK-Activated Protein Kinase (MAPKAPK) family","Cycl
in-dependent kinase-like (CDKL) family","DMPK family","CLK family","RCK family","STE11 family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","RSK family","Protein kinase D
 (PKD) family","CAMK1 family","Death-associated kinase (DAPK) family","Myosin Light Chain Kinase (MLCK) family","Non-receptor tyrosine kinases (nRTKs)","Mixed Lineage Kinase (MLK) family","NKF4 family
","HIPK subfamily","CRK7 subfamily","Receptor tyrosine kinases (RTKs)","TAIRE subfamily","CDK9 subfamily","PITSLRE subfamily","JNK subfamily","CAMKK family","NIMA (never in mitosis gene a)- related ki
nase (NEK) family","MST subfamily","LIM domain kinase (LISK) family","KHS subfamily","TAO subfamily","AMPK subfamily","MSN subfamily","MKN subfamily","p38 subfamily","Aurora kinase (Aur) family","GEK 
subfamily","Receptor interacting protein kinase (RIPK) family","Dyrk2 subfamily","Polo-like kinase (PLK) family","HUNK subfamily","CHK1 subfamily","CDK8 subfamily","CDK7 subfamily","Unc-51-like kinase
 (ULK) family","QIK subfamily","RAF family","p70 subfamily","Other DMPK family kinases","IKK family","PEK family","SLK subfamily","NinaC subfamily","Rho kinase","YSK subfamily","PAKA subfamily","TTK f
amily","RSK subfamily","STE20 subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","nmo subfamily","Casein kinase 2 (CK2) family","Erk7 subfamily","Other-unique family","MELK subfamily"
,"Fak family","MLK subfamily","Src family","Tec family","Janus kinase (JakA) family","Type XVI RTKs: DDR (collagen receptor) family","Type XIII RTKs: Ephrin receptor family","LZK subfamily","Type I RT
Ks: ErbB (epidermal growth factor) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Meta subfamily","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type I
V RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type II RTKs: Insulin receptor family","Abl family","Type XII RTKs: TIE famil
y of angiopoietin receptors","TESK subfamily","Type XVII RTKs: ROS receptors","Ack family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type VII RTKs: Neurotrophin receptor/Trk fami
ly","Fer family","LIMK subfamily","Type IX RTKs: MuSK","Type XIV RTKs: RET","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Csk family","Other PEK family kinases","TAK1 subfamily","H
H498 subfamily","Syk family"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Gene expression (Transcription)",Disease,"Extracellular matrix organization","Developmental Biology","Cell Cycle","Neuronal System",Metabolism,"Cell-Cell commun
ication","Cellular responses to external stimuli","Organelle biogenesis and maintenance","Circadian Clock",Hemostasis,"Programmed Cell Death","Cytokine Signaling in Immune system","Signaling by Recept
or Tyrosine Kinases","RNA Polymerase II Transcription","Infectious disease","Non-integrin membrane-ECM interactions","Nervous system development",Mitotic,"Intracellular signaling by second messengers"
,"Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System","Transmission across Chemical Synapses","Metabolism of lipids","Signaling by GPCR","Adaptive 
Immune System","Signaling by Hippo","Cell junction organization","Cellular responses to stress","MAPK family signaling cascades","Cilium Assembly","ECM proteoglycans","Signaling by Non-Receptor Tyrosi
ne Kinases","Signaling by Hedgehog","MTOR signalling","Cell surface interactions at the vascular wall","Signaling by Rho GTPases",Apoptosis,"Signaling by WNT","Signaling by Interleukins","Signaling by
 NTRKs","Generic Transcription Pathway","HIV Infection","Interferon Signaling","Axon guidance","Leishmania infection","Mitotic G2-G2/M phases","PIP3 activates AKT signaling","Signaling by FGFR in dise
ase","Toll-like Receptor Cascades","Neurotransmitter receptors and postsynaptic signal transmission","M Phase","Phospholipid metabolism","Signaling by VEGF","Signaling by MST1","Signaling by Insulin r
eceptor","Signaling by KIT in disease","GPCR downstream signalling","TCR signaling","Mitotic G1 phase and G1/S transition","Signaling by PDGFR in disease","Cell-extracellular matrix interactions","Cel
lular Senescence","Signaling by FGFR","Oncogenic MAPK signaling","MAPK1/MAPK3 signaling","Cargo trafficking to the periciliary membrane","Signaling by SCF-KIT","Signaling by NOTCH1 in Cancer","Signali
ng by PTK6","Hedgehog 'on' state","mTORC1-mediated signalling","Sphingolipid metabolism","RHO GTPase Effectors","Response of EIF2AK1 (HRI) to heme deficiency","Fc epsilon receptor (FCERI) signaling","
Caspase activation via extrinsic apoptotic signalling pathway","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Neutrophil degranulation","Regulation of lipid metabolism by PPARalp
ha","Beta-catenin independent WNT signaling","Interleukin-2 family signaling","Signaling by NTRK1 (TRKA)","Transcriptional Regulation by TP53","Host Interactions of HIV factors",Interleukin-3,"Interle
ukin-5 and GM-CSF signaling","Interferon alpha/beta signaling","EPH-Ephrin signaling","Leishmania parasite growth and survival","HIV Life Cycle","G2/M Transition","Negative regulation of the PI3K/AKT 
network","Signaling by FGFR1 in disease","Toll Like Receptor 5 (TLR5) Cascade","Activation of NMDA receptors and postsynaptic events","Mitotic Prophase","Semaphorin interactions","PI Metabolism","VEGF
A-VEGFR2 Pathway","Insulin receptor signalling cascade","Signaling by FGFR3 in disease","Drug resistance of KIT mutants","Parasite infection","G alpha (q) signalling events","Generation of second mess
enger molecules","G1 Phase","Drug resistance of PDGFR mutants","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","VEGF ligand-receptor interactions","Oxidative Stres
s Induced Senescence","Signaling by FGFR4","Signaling by RAS mutants","Toll Like Receptor 4 (TLR4) Cascade","RAF/MAP kinase cascade","BBSome-mediated cargo-targeting to cilium","Signaling by NTRK3 (TR
KC)","Transcriptional Regulation by VENTX","Mitotic Metaphase and Anaphase","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","RET signaling","Signaling by FGFR2 in disease","PTK6 Down-Regulation
","Interleukin-1 family signaling","Signaling by ROBO receptors","Sphingolipid de novo biosynthesis","RHO GTPases activate CIT","FCERI mediated Ca+2 mobilization","Caspase activation via Dependence Re
ceptors in the absence of ligand","Transcriptional regulation by RUNX1","IGF1R signaling cascade","Toll Like Receptor 2 (TLR2) Cascade","PPARA activates gene expression","Ca2+ pathway","PTEN Regulatio
n","Interleukin-2 signaling","Signalling to ERK5","Regulation of TP53 Activity","The role of Nef in HIV-1 replication and disease pathogenesis","Regulation of IFNA signaling","TP53 Regulates Transcrip
tion of DNA Repair Genes","EPHA-mediated growth cone collapse","Anti-inflammatory response favouring Leishmania parasite infection","Late Phase of HIV Life Cycle","Centrosome maturation",PI5P,"PP2A an
d IER3 Regulate PI3K/AKT Signaling","FGFR1 mutant receptor activation","MyD88 cascade initiated on plasma membrane","Post NMDA receptor activation events","Nuclear Envelope Breakdown","Sema4D in semap
horin signaling","Synthesis of PIPs at the plasma membrane","VEGFR2 mediated cell proliferation","IRS-mediated signalling","EPHB-mediated forward signaling","Signaling by FGFR3 point mutants in cancer
","Dasatinib-resistant KIT mutants","Leishmania phagocytosis","Gastrin-CREB signalling pathway via PKC and MAPK","Cyclin D associated events in G1","Imatinib-resistant PDGFR mutants","VEGF binds to VE
GFR leading to receptor dimerization","Negative regulation of FGFR4 signaling","Signaling downstream of RAS mutants","Signalling to ERKs","MyD88-independent TLR4 cascade","Activated NTRK3 signals thro
ugh PI3K","Activation of TRKA receptors","Mitotic Anaphase","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","FGFR2 mutant receptor activation","Interleukin-1 signaling","Negative regulation 
of MAPK pathway","Role of ABL in ROBO-SLIT signaling","RUNX1 regulates transcription of genes involved in BCR signaling","CRMPs in Sema3A signaling","Ephrin signaling","IRS-related events triggered by
 IGF1R","Toll Like Receptor TLR6:TLR2 Cascade","Regulation of PTEN stability and activity","Regulation of TP53 Activity through Phosphorylation","Nef and signal transduction","FCGR3A-mediated IL10 syn
thesis","Transcription of the HIV genome","Loss of proteins required for interphase microtubule organization from the centrosome","Signaling by activated point mutants of FGFR1","Recruitment of mitoti
c centrosome proteins and complexes","MAP kinase activation","Activation of RAC1 downstream of NMDARs","Activation of NIMA Kinases NEK9",NEK6,NEK7,"Sema4D mediated inhibition of cell attachment and mi
gration","PI3K Cascade","FGFR3 mutant receptor activation","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone collapse","Long-term potentia
tion","Spry regulation of FGF signaling","Signalling to RAS","TRIF(TICAM1)-mediated TLR4 signaling","NGF-independant TRKA activation","Separation of Sister Chromatids","Activation of AMPK downstream o
f NMDARs","Regulation of TP53 Expression and Degradation","Activated point mutants of FGFR2","Regulation of TP53 Activity through Acetylation","Prolonged ERK activation events","Negative feedback regu
lation of MAPK pathway","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","HIV Transcription Elon
gation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Signaling by activated point mutants of FGFR3","p38MAPK events","IKK complex recruitment mediated
 by RIP1","activated TAK1 mediates p38 MAPK activation","Regulation of TP53 Degradation","PI5P Regulates TP53 Acetylation","Frs2-mediated activation","ARMS-mediated activation","Activation of IRF3/IRF
7 mediated by TBK1/IKK epsilon","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Nef Mediated CD4 Down-regulation","Tat-mediated elongation of the HIV-1 transcript","Activation of the A
P-1 family of transcription factors","CREB phosphorylation","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{FLT1,FLT4,KDR,MET}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{Foretinib,849217-64-7,849217647,GSK1363089,XL880,"Foretinib (GSK1363089)",XL-880,EXEL-2880,EXEL2880,"GSK 1363089","XL 880",GSK089,"EXEL 2880",GSK-1363089,UNII-81FH7VK1C4,UNII81FH7VK1C4,81FH7VK1C4,GSK
-089,GSK1363089G,"Foretinib (XL-880)","Foretinib (XL880)",937176-80-2,937176802,C34H34F2N4O6,88Z,Foretinib(XL880),T3113,S1111,foretinib,XL880(GSK1363089)}

> <pdid>
PD003567

> <targets>
{"c-Met | VEGFR-PDGFR",VEGFR,c-Met}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{42642645}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  0  0            999 V2000
   -1.3553   -2.5513    0.0000 C   0  0
   -0.4775   -3.7676    0.0000 O   0  0
    1.0157   -3.6164    0.0000 C   0  0
    1.6281   -2.2462    0.0000 C   0  0
    3.1202   -2.0921    0.0000 O   0  0
    0.7500   -1.0323    0.0000 N   0  0
    1.2135    0.3943    0.0000 C   0  0
    0.0000    1.2760    0.0000 C   0  0
   -0.4623    2.7009    0.0000 N   0  0
   -1.9623    2.7008    0.0000 N   0  0
   -2.4258    1.2743    0.0000 C   0  0
   -3.8515    0.8135    0.0000 N   0  0
   -4.9659    1.8188    0.0000 C   0  0
   -4.6522    3.2856    0.0000 O   0  0
   -6.3940    1.3573    0.0000 C   0  0
   -7.5092    2.3604    0.0000 C   0  0
   -8.9356    1.8962    0.0000 C   0  0
   -9.2468    0.4288    0.0000 C   0  0
   -8.1316   -0.5743    0.0000 C   0  0
   -6.7052   -0.1101    0.0000 C   0  0
  -10.6739   -0.0356    0.0000 N   0  0
  -11.7908    0.9658    0.0000 C   0  0
  -13.2164    0.4993    0.0000 C   0  0
  -13.5252   -0.9685    0.0000 N   0  0
  -14.9509   -1.4350    0.0000 C   0  0
  -12.4085   -1.9699    0.0000 C   0  0
  -10.9828   -1.5035    0.0000 C   0  0
   -1.2135    0.3943    0.0000 C   0  0
   -0.7500   -1.0323    0.0000 C   0  0
    1.8954   -4.8324    0.0000 C   0  0
    1.2853   -6.2028    0.0000 C   0  0
    2.1669   -7.4164    0.0000 C   0  0
    3.6587   -7.2596    0.0000 C   0  0
    4.2689   -5.8893    0.0000 C   0  0
    3.3872   -4.6758    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 18 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 26 27  1  0
 27 21  1  0
 11 28  1  0
 28  8  2  0
 28 29  1  0
 29  6  1  0
  3 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28436

> <plate>
Kinase v5-2

> <well>
G05

> <supplier_cmpd_name>
PHA-739358(Danusertib)

> <ctcr_id>
1335

> <supplier_cmpd_id>
S1107

> <smiles>
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N4CCN(C)CC4)c2C1)c5ccccc5

> <pd_targets>
{AURKC,AURKA,AURKB,LCK,SLK,ABL1,FGFR1,FLT4,KDR,CDK2,FLT3,PLK1,NTRK1,RET,KIT,CAMK2G,MARK3,CAMK2B,MARK2,FLT1,EPHA2,NTRK2,SYK,FES,MAP4K2,ALK,PLK4,NTRK3,PRKAA1,PRKCD,LRRK2,EGFR,PTK6,ITK,PRKD3,FGFR3,CAMK2D
,CLK4,CLK2,CSF1R,BRSK1,PRKD2,FRK,MAP4K4,PHKG2,LIMK1,JAK2,DAPK3,PAK4,JAK3,TSSK1B,BTK,FYN,MAP4K5,DCLK1,STK3,SRC,ACVR1,CDK7,FER,LTK,TNK2,TAOK1,CDK5,ROS1,PTK2,MST1R,SRMS,LYN,BLK,MELK,PKN2,CDK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","TK protein kinase group","STE protein kinase group","CMGC protein kinase group","Other protein kinase AUR family","Tyrosine protein kinase
 Src family","STE protein kinase STE20 family","Tyrosine protein kinase Abl family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase VEGFR family","CMGC protein kinase CDK family","Tyros
ine protein kinase PDGFR family","Other protein kinase PLK family","Tyrosine protein kinase Trk family","Tyrosine protein kinase Ret family","STE protein kinase SLK subfamily","CMGC protein kinase CDC
2 subfamily","CAMK protein kinase group","TKL protein kinase group","AGC protein kinase group","CAMK protein kinase CAMK2 family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Eph family
","Tyrosine protein kinase Syk family","Tyrosine protein kinase Fer family","TKL protein kinase STKR family","AGC protein kinase PKC family","TKL protein kinase LRRK family","Tyrosine protein kinase E
GFR family","Tyrosine protein kinase Tec family","CAMK protein kinase PKD family","CMGC protein kinase CLK family","CAMK protein kinase PHk family","TKL protein kinase LISK family","Tyrosine protein k
inase JakA family","CAMK protein kinase DAPK family","CAMK protein kinase TSSK family","CAMK protein kinase DCAMK1 family","Tyrosine protein kinase Alk family","Tyrosine protein kinase Ack family","Ty
rosine protein kinase Sev family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Met family","AGC protein kinase PKN family","CAMK protein kinase MARK subfamily","STE protein kinase KHS
 subfamily","TKL protein kinase STKR Type 1 subfamily","CAMK protein kinase AMPK subfamily","AGC protein kinase PKC delta subfamily","CAMK protein kinase BRSK subfamily","STE protein kinase MSN subfam
ily","TKL protein kinase LIMK subfamily","STE protein kinase PAKB subfamily","Tyrosine protein kinase SrcA","STE protein kinase MST subfamily","TKL protein kinase STKR1","CMGC protein kinase CDK7 subf
amily","STE protein kinase TAO subfamily","CMGC protein kinase CDK5 subfamily","Tyrosine protein kinase Srm","CAMK protein kinase MELK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families",
"Other protein kinases","TK: Tyrosine kinase","STE20 family","Cyclin-dependent kinase (CDK) family","Aurora kinase (Aur) family","Non-receptor tyrosine kinases (nRTKs)","SLK subfamily","Receptor tyros
ine kinases (RTKs)","CDK1 subfamily","Polo-like kinase (PLK) family","Src family","Abl family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial g
rowth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XIV RTKs: RET","CAMK: Calcium/calmodulin-dependent protein
 kinases","AGC: Containing PKA",PKG,"PKC families","CAMK2 family","CAMK-like (CAMKL) family","Protein kinase C (PKC) family","TKL: Tyrosine kinase-like","Protein kinase D (PKD) family","CLK family","P
hosphorylase kinase (PHK) family","Death-associated kinase (DAPK) family","Testis specific kinase (TSSK) family","DCAMKL family","Protein kinase N (PKN) family","MARK subfamily","KHS subfamily","AMPK 
subfamily","Delta subfamily","Leucine-rich repeat kinase (LRRK) family","BRSK subfamily","MSN subfamily","LIM domain kinase (LISK) family","PAKB subfamily","MST subfamily","Receptor serine/threonine k
inase (RSTK) family","CDK7 subfamily","TAO subfamily","CDK5 subfamily","MELK subfamily","Type XIII RTKs: Ephrin receptor family","Syk family","Fer family","Type XIX RTKs: Leukocyte tyrosine kinase (LT
K) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Tec family","LIMK subfamily","Janus kinase (JakA) family","Type I receptor serine/threonine kinases","Ack family","Ty
pe XVII RTKs: ROS receptors","Fak family","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle",Disease,"Signal Transduction","Developmental Biology","RNA Polymerase II Transcription",Mitotic,"Infectious disease","Diseases of signal transduction by
 growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","Nervous system development","Generic Transcription Pathway","M Phase","HIV Infection","Leishmania infection","
Signaling by FGFR in disease","Signaling by VEGF","Signaling by Insulin receptor","Mitotic G2-G2/M phases","Signaling by NTRKs","Axon guidance","Signaling by KIT in disease","Transcriptional Regulatio
n by TP53","Mitotic Metaphase and Anaphase","Host Interactions of HIV factors","Parasite infection","Signaling by FGFR1 in disease","VEGF ligand-receptor interactions","VEGFA-VEGFR2 Pathway","Insulin 
receptor signalling cascade","G2/M Transition","Signaling by NTRK1 (TRKA)","RET signaling","Drug resistance of KIT mutants","Regulation of TP53 Activity","Mitotic Anaphase","The role of Nef in HIV-1 r
eplication and disease pathogenesis","Leishmania phagocytosis","FGFR1 mutant receptor activation","VEGF binds to VEGFR leading to receptor dimerization","VEGFR2 mediated cell proliferation","IRS-media
ted signalling","Centrosome maturation","Signalling to ERKs","Dasatinib-resistant KIT mutants","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids","Nef-mediates dow
n modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated phagocytosis","Signaling by activated point mutants of FGFR1","Regulation of TP53 Expression and Degrad
ation","PI3K Cascade","Loss of proteins required for interphase microtubule organization from the centrosome","Prolonged ERK activation events","Nef Mediated CD4 Down-regulation","Regulation of TP53 D
egradation","Loss of Nlp from mitotic centrosomes","ARMS-mediated activation","Neuronal System","Immune System",Metabolism,"Cellular responses to external stimuli","Programmed Cell Death","Transmissio
n across Chemical Synapses","Intracellular signaling by second messengers","Signaling by Non-Receptor Tyrosine Kinases","Signaling by GPCR","Adaptive Immune System","Metabolism of lipids","Cellular re
sponses to stress","Metabolism of carbohydrates",Apoptosis,"Cytokine Signaling in Immune system","Signaling by Hippo","Signaling by Rho GTPases","Neurotransmitter receptors and postsynaptic signal tra
nsmission","Oncogenic MAPK signaling","DAG and IP3 signaling","Signaling by PTK6","GPCR downstream signalling","Mitotic G1 phase and G1/S transition","TCR signaling","Sphingolipid metabolism","PIP3 ac
tivates AKT signaling","Cellular Senescence","Glycogen metabolism","Caspase activation via extrinsic apoptotic signalling pathway","Signaling by Interleukins","Signaling by SCF-KIT","Signaling by MST1
","RHO GTPase Effectors","Regulation of mitotic cell cycle","Activation of NMDA receptors and postsynaptic events","Signaling by RAS mutants","EPH-Ephrin signaling","Leishmania parasite growth and sur
vival","Semaphorin interactions","Signaling by NTRK3 (TRKC)","CaM pathway","PTK6 promotes HIF1A stabilization","G alpha (q) signalling events","G1 Phase","Generation of second messenger molecules","Sp
hingolipid de novo biosynthesis","Signaling by FGFR3 in disease","Transcriptional Regulation by VENTX","PTEN Regulation","Oxidative Stress Induced Senescence","Glycogen breakdown (glycogenolysis)","Ca
spase activation via Dependence Receptors in the absence of ligand","Signaling by ROBO receptors","Interleukin-2 family signaling","HIV Life Cycle","PTK6 Down-Regulation","Transcriptional regulation b
y RUNX1","RHO GTPases activate PKNs","APC/C-mediated degradation of cell cycle proteins","Post NMDA receptor activation events","Signaling downstream of RAS mutants","EPHA-mediated growth cone collaps
e","Activation of TRKA receptors","Anti-inflammatory response favouring Leishmania parasite infection","CRMPs in Sema3A signaling","Activated NTRK3 signals through PI3K","Calmodulin induced events","G
astrin-CREB signalling pathway via PKC and MAPK","Cyclin D associated events in G1","Signaling by FGFR3 point mutants in cancer","Regulation of PTEN stability and activity","Sema4D in semaphorin signa
ling","Activation of RAC1","Interleukin-15 signaling","Late Phase of HIV Life Cycle","RUNX1 regulates transcription of genes involved in BCR signaling","Activation of APC/C and APC/C:Cdc20 mediated de
gradation of mitotic proteins","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","NGF-independant TRKA activation","FCGR3A-mediated IL10 synthesis","EGFR Transactivati
on by Gastrin","FGFR3 mutant receptor activation","Sema4D induced cell migration and growth-cone collapse","Nef and signal transduction","Signalling to RAS","Transcription of the HIV genome","APC/C:Cd
c20 mediated degradation of mitotic proteins","Ras activation upon Ca2+ influx through NMDA receptor","Signaling by activated point mutants of FGFR3","p38MAPK events","HIV Transcription Elongation","A
PC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Tat-mediated elongation of the HIV-1 transcript","Cdc20:Phospho-APC/C mediated degradation of C
yclin A","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HA739358(DANUSERTIB,CHEMBL1981047,Kinome_3738,Kinome3738,Kinome-3738,"Kinome 3738",ACMC-20c501,ACMC20c501,SCHEMBL2685432,HMS3244O13,HMS3244O14,HMS3244P13,HMS3654A04,BDBM50466807,AKOS015851423,NCGC003
89696-01,NCGC0038969601,AK468661,DB-014747,DB014747,FT-0665468,FT0665468,136M937,T2094,S1107,Danusertib,PHA-739358(Danusertib),"Danusertib (PHA-739358)"}

> <pdid>
PD011133

> <targets>
{"Aurora | FGFR | Src-bcr-Abl","Aurora Kinase",c-RET,FGFR,Bcr-Abl}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{21874004}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 32  0  0  0  0            999 V2000
    6.8970   -5.5078    0.0000 O   0  0
    6.5365   -4.0517    0.0000 C   0  0
    7.6181   -3.0113    0.0000 N   0  0
    9.0603   -3.4268    0.0000 C   0  0
   10.4292   -3.0435    0.0000 C   0  0
   10.0108   -4.4839    0.0000 C   0  0
    5.0944   -3.6362    0.0000 N   0  0
    4.0146   -4.6747    0.0000 C   0  0
    4.2107   -6.1619    0.0000 C   0  0
    2.8570   -6.8080    0.0000 N   0  0
    1.8242   -5.7201    0.0000 N   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 N   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 O   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  4  1  0
  2  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12  8  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 19  1  0
 17 25  2  0
 25 26  1  0
 26 27  2  0
 27 15  1  0
 27 28  1  0
 28 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28437

> <plate>
Kinase v5-2

> <well>
G07

> <supplier_cmpd_name>
AT9283

> <ctcr_id>
11442

> <supplier_cmpd_id>
S1134

> <smiles>
O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{BDBM27087,J-504568,J504568,GTPL7949,SCHEMBL15005492,SCHEMBL15005494,AT9283,896466-04-9,896466049,AT-9283,"AT 9283",UNII-XAV9KYN9WL,UNIIXAV9KYN9WL,"AT-9283 free base","AT9283 free base",XAV9KYN9WL,CHE
MBL495727,"896466-04-9 (free base)","896466049 (free base)","AT 9283, (2S)-2-hydroxy-propanoic acid salt","AT 9283, (2S)2hydroxypropanoic acid salt",C19H23N7O2,896466-7,8964667,T3068}

> <pdid>

> <targets>
{"Aurora | FLT-3 | JAK | Src-bcr-Abl","Aurora A","Aurora B","Abl1 (T315I)",JAK2,JAK3}

> <classes>
{Angiogenesis,"Cell Cycle/Checkpoint",Chromatin/Epigenetic,"Cytoskeletal Signaling","JAK/STAT signaling","Stem Cells"}

> <pubchem_cids>
{135398495}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 43  0  0  0  0            999 V2000
    3.8756   -9.7579    0.0000 C   0  0
    3.8808   -8.2579    0.0000 N   0  0
    5.1824   -7.5124    0.0000 C   0  0
    5.1876   -6.0124    0.0000 C   0  0
    3.8912   -5.2578    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 O   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    3.9072    5.2405    0.0000 O   0  0
    3.9020    3.7405    0.0000 C   0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.6012    3.0008    0.0000 N   0  0
   -3.9020    3.7494    0.0000 C   0  0
   -5.1985    2.9949    0.0000 C   0  0
   -5.1934    1.4949    0.0000 Cl  0  0
   -6.5002    3.7404    0.0000 C   0  0
   -6.5054    5.2404    0.0000 C   0  0
   -5.2089    5.9949    0.0000 C   0  0
   -4.9026    7.4624    0.0000 O   0  0
   -3.4113    7.6244    0.0000 C   0  0
   -2.7965    6.2562    0.0000 O   0  0
   -3.9073    5.2494    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.5895   -6.0034    0.0000 C   0  0
    2.5844   -7.5034    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 13  1  0
 11 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 22  1  0
 31 27  2  0
 20 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 19  1  0
 35 36  2  0
 36  9  1  0
  5 37  1  0
 37 38  1  0
 38  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28438

> <plate>
Kinase v5-2

> <well>
G09

> <supplier_cmpd_name>
AZD0530(Saracatinib)

> <ctcr_id>
1479

> <supplier_cmpd_id>
S1006

> <smiles>
CN1CCN(CCOc2cc(OC3CCOCC3)c4c(Nc5c(Cl)ccc6OCOc56)ncnc4c2)CC1

> <pd_targets>
{SRC,KDR,CSK,YES1,LCK,KIT,ABL1,PKMYT1,EGFR,CDK2,PDGFRA,MAP2K1,MAP2K2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","CMGC protein kinase group","STE protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kin
ase VEGFR family","Tyrosine protein kinase Csk family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Abl family","Other protein kinase WEE family","Tyrosine protein kinase EGFR famil
y","CMGC protein kinase CDK family","STE protein kinase STE7 family","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Other protein kinases","Cyclin-dependent kinas
e (CDK) family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","WEE family","CDK1 subfamily","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor 
family","Csk family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Abl family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Cell Cycle","Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers
","Infectious disease",Mitotic,"Signaling by GPCR","RNA Polymerase II Transcription","Signaling by NTRKs","Signaling by VEGF","Oncogenic MAPK signaling","Leishmania infection","HIV Infection","Signali
ng by KIT in disease","Mitotic G2-G2/M phases","GPCR downstream signalling","Generic Transcription Pathway","Signaling by PDGFR in disease","Signaling by NTRK1 (TRKA)","VEGFA-VEGFR2 Pathway","Signalin
g by RAS mutants","Leishmania parasite growth and survival","Host Interactions of HIV factors","Drug resistance of KIT mutants","Parasite infection","G2/M Transition","G alpha (q) signalling events","
Transcriptional Regulation by TP53","Drug resistance of PDGFR mutants","Signalling to ERKs","VEGFR2 mediated cell proliferation","Signaling downstream of RAS mutants","Anti-inflammatory response favou
ring Leishmania parasite infection","The role of Nef in HIV-1 replication and disease pathogenesis","Dasatinib-resistant KIT mutants","Leishmania phagocytosis","Cyclin A/B1/B2 associated events during
 G2/M transition","Gastrin-CREB signalling pathway via PKC and MAPK","Regulation of TP53 Activity","Imatinib-resistant PDGFR mutants","Signalling to RAS","FCGR3A-mediated IL10 synthesis","Nef-mediates
 down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Regulation of TP53 Expression and Degradation","p3
8MAPK events","Nef Mediated CD4 Down-regulation","Regulation of TP53 Degradation"}

> <broad_targets>
{ABL1,LCK,SRC,YES1}

> <broad_moa>
{"SRC inhibitor"}

> <synonyms>
{Saracatinib,379231-04-6,379231046,"Saracatinib (AZD0530)",AZD0530,AZD-0530,"AZD 0530",UNII-9KD24QGH76,UNII9KD24QGH76,"SARACATINIB, FREE BASE",9KD24QGH76,CHEMBL217092,H8H,nchembio866-comp19,nchembio86
6comp19,"Saracatinib (USAN:INN)",2h8h,"Saracatinib,AZD0530","Saracatinib (USAN",T6078,S1006,saracatinib,AZD0530(Saracatinib),SARACATINIB}

> <pdid>
PD003218

> <targets>
{Src-bcr-Abl,"SRC/ABL Inhibitors",ABL,SRC,Autophagy,Src}

> <classes>
{Autophagy,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{10302451}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 39  0  0  0  0            999 V2000
    3.8794    3.7535    0.0000 C   0  0
    5.1821    3.0099    0.0000 O   0  0
    5.1903    1.5091    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8994   -3.7478    0.0000 O   0  0
   -5.1981   -2.9955    0.0000 C   0  0
   -6.4993   -3.7433    0.0000 C   0  0
   -7.7980   -2.9910    0.0000 C   0  0
   -9.0993   -3.7387    0.0000 N   0  0
  -10.3984   -2.9888    0.0000 C   0  0
  -11.6975   -3.7388    0.0000 C   0  0
  -11.6975   -5.2388    0.0000 N   0  0
  -12.9965   -5.9887    0.0000 C   0  0
  -10.3985   -5.9888    0.0000 C   0  0
   -9.0994   -5.2388    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 O   0  0
    0.0042   -5.9990    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 C   0  0
    0.0000    4.5008    0.0000 N   0  0
    5.2007   -1.4909    0.0000 C   0  0
    5.2059   -2.9909    0.0000 Cl  0  0
    6.4972   -0.7364    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    7.7884    1.5180    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 21 23  1  0
 23 24  1  0
 24 18  1  0
 13 25  2  0
 25 26  1  0
 26 27  1  0
 25 28  1  0
 28 29  2  0
 29  7  1  0
 29 11  1  0
  9 30  1  0
 30 31  3  0
  5 32  2  0
 32 33  1  0
 32 34  1  0
 34 35  2  0
 35  3  1  0
 35 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28439

> <plate>
Kinase v5-2

> <well>
G11

> <supplier_cmpd_name>
Bosutinib(SKI-606)

> <ctcr_id>
3439

> <supplier_cmpd_id>
S1014

> <smiles>
COc1cc(Nc2cc(nc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{OSUTINIB(SKI606,CHEMBL3182697,NCGC00390366-01,NCGC0039036601,BRD-K90746395-001-02-3,BRDK90746395001023,S1014,Bosutinib(SKI-606)}

> <pdid>
PD003622

> <targets>
{Src-bcr-Abl}

> <classes>
{}

> <pubchem_cids>
{46926609}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.4470    5.2297    0.0000 S   0  0
   -2.9153    5.5365    0.0000 C   0  0
   -3.6607    4.2349    0.0000 C   0  0
   -2.6532    3.1236    0.0000 N   0  0
   -3.5322    6.9018    0.0000 C   0  0
   -2.6569    8.1199    0.0000 O   0  0
   -5.0256    7.0513    0.0000 N   0  0
   -5.6437    8.4190    0.0000 C   0  0
   -7.1360    8.5706    0.0000 C   0  0
   -8.0134    7.3540    0.0000 C   0  0
   -7.7509    9.9388    0.0000 C   0  0
   -6.8735   11.1554    0.0000 C   0  0
   -5.3812   11.0039    0.0000 C   0  0
   -4.7663    9.6357    0.0000 C   0  0
   -3.2739    9.4842    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 N   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 N   0  0
   -6.4915   -3.7597    0.0000 C   0  0
   -6.4870   -5.2605    0.0000 C   0  0
   -7.7833   -6.0153    0.0000 O   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10  6  2  0
  8 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 14  1  0
 20 21  1  0
  4 22  2  0
 22 23  1  0
 23 24  2  0
 24  2  1  0
 23 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 28 32  1  0
 32 33  1  0
 33 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28440

> <plate>
Kinase v5-2

> <well>
G13

> <supplier_cmpd_name>
Dasatinib

> <ctcr_id>
6468

> <supplier_cmpd_id>
S1021

> <smiles>
Cc1nc(Nc2sc(cn2)C(=O)Nc3c(C)cccc3Cl)cc(n1)N4CCN(CCO)CC4

> <pd_targets>
{EPHB6,ERBB4,LCK,SRC,ABL1,BCR,BTK,EPHA2,CSK,CSNK1E,EPHB1,EPHB4,TUBA1A,RAF1,RET,RIPK2,PDGFRA,MAP4K3,BLK,MAP4K4,BMX,MAP4K2,TESK1,EPHA1,EGFR,ERBB2,FGFR1,KIT,TYK2,BMPR1B,PLK4,LIMK1,LIMK2,MAP2K1,SIK2,ACVR2
A,GAK,DDR2,IRAK4,ACVRL1,COQ8A,TAOK2,TAOK3,CDPK1,DYRK3,MAPK14,MAP4K1,PDGFRB,SLK,HTR2A,BRAF,FGR,FGFR2,NLK,FLT3,KCNH2,NORA,EPHB3,WEE2,JAK2,STK4,STK10,DDR1,STK36,EPHA8,FLT1,SBK1,TNIK,TXK,EPHB2,MINK1,MAPK1
1,ACVR1B,ACVR1,MAP4K5,TEC,DMPK,REP,KDR,FRK,WEE1,MAP3K20,TGFBR1,PTK6,SIK3,YES1,MAP3K19,MAP3K7,NEK11,MAPK12,MAPK13,HCK,JAK3,CDC42BPA,AURKA,FGFR3,MAP3K3,CYP3A4,STK26,ABL2,SIK1,SRMS,SYK,EIF2AK4,MAP3K13,PI
K3CA,PKMYT1,CSF1R,EPHA4,STK25,LYN,MAP2K2,CDC42BPB,TGFBR2,CDC42BPG,ACVR2B,EPHA6,MAP2K5,TNK2,PIK3CD,MTOR,MAP3K4,ULK3,ERBB3,MYLK2,FYN,TNNI3K,TAOK1,EPHA5,NEK2,AXL,VRK2,HTT,AURKB,EPHA3,PKN2,FES,STK35,MAP3K
10,BMPR1A,MAP3K2,ITK,ABCB11,MYT1,CACNA1C,CACNA1D,CACNA1F,CACNA1S,ABCC4,SCN5A,STAT5B}

> <pathway_gtopdb>
{"Unclassified protein",Enzyme,"Structural protein","Membrane receptor","Ion channel",Transporter,"Transcription factor",Kinase,"Family A G protein-coupled receptor","Voltage-gated ion channel","Cytoc
hrome P450",Transferase,"Primary active transporter","Protein Kinase","Small molecule receptor (family A GPCR)","Potassium channels","Cytochrome P450 family 3","ATP-binding cassette","Voltage-gated ca
lcium channel","Voltage-gated sodium channel","TK protein kinase group","Atypical protein kinase group","CK1 protein kinase group","TKL protein kinase group","STE protein kinase group","Other protein 
kinase group","CAMK protein kinase group","CMGC protein kinase group","Monoamine receptor","Voltage-gated potassium channel","AGC protein kinase group","Cytochrome P450 family 3A","ABCB subfamily","AB
CC subfamily","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Src family","Atypical protein kinase BCR family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Tec family",
"Tyrosine protein kinase Eph family","Tyrosine protein kinase Csk family","CK1 protein kinase CK1 family","TKL protein kinase RAF family","Tyrosine protein kinase Ret family","TKL protein kinase RIPK 
family","Tyrosine protein kinase PDGFR family","STE protein kinase STE20 family","TKL protein kinase LISK family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase JakA family","TKL prote
in kinase STKR family","Other protein kinase PLK family","STE protein kinase STE7 family","CAMK protein kinase CAMK1 family","Other protein kinase NAK family","Tyrosine protein kinase DDR family","TKL
 protein kinase IRAK family","CMGC protein kinase DYRK family","CMGC protein kinase MAPK family","Serotonin receptor","Other protein kinase WEE family","Other protein kinase ULK family","Tyrosine prot
ein kinase VEGFR family","Other protein kinase NKF1 family","AGC protein kinase DMPK family","TKL protein kinase MLK family","STE protein kinase STE11 family","Other protein kinase NEK family","Other 
protein kinase AUR family","Cytochrome P450 3A4","Tyrosine protein kinase Syk family","Other protein kinase PEK family","Tyrosine protein kinase Ack family","Atypical protein kinase PIKK family","CAMK
 protein kinase MLCK family","Tyrosine protein kinase Axl family","AGC protein kinase PKN family","Tyrosine protein kinase Fer family","Other protein kinase NKF4 family","STE protein kinase KHS subfam
ily","STE protein kinase MSN subfamily","TKL protein kinase TESK subfamily","TKL protein kinase STKR Type 1 subfamily","TKL protein kinase LIMK subfamily","CAMK protein kinase QIK subfamily","TKL prot
ein kinase STKR Type 2 subfamily","STE protein kinase TAO subfamily","CMGC protein kinase Dyrk2 subfamily","CMGC protein kinase p38 subfamily","STE protein kinase SLK subfamily","CMGC protein kinase n
mo subfamily","Other protein kinase WEE1","STE protein kinase MST subfamily","TKL protein kinase STKR1","AGC protein kinase GEK subfamily","TKL protein kinase MLK subfamily","TKL protein kinase TAK1 s
ubfamily","Other protein kinase Nek11","STE protein kinase MEKK2","STE protein kinase YSK subfamily","Tyrosine protein kinase Srm","Other protein kinase GCN2 subfamily","TKL protein kinase LZK subfami
ly","Atypical protein kinase FRAP subfamily","Tyrosine protein kinase SrcA","TKL protein kinase HH498 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Ion channels",Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)",Tubulins,"G protein-coupled receptors","Voltage-gated ion channels","Anti-infective 
targets","Cytochrome P450","ATP-binding cassette transporter family","Receptor kinases","CK1: Casein kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmo
dulin-dependent protein kinases",Atypical,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","5-Hydroxytryptamine receptors","Potassium channels","AGC: Containing PKA",PKG,"PKC families","Viral protein t
argets","CYP3 family","Lipid modifying kinases","ABCB subfamily","ABCC subfamily","Voltage-gated sodium channels","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","TKL: Tyrosine kinase-like","STE2
0 family","Other protein kinases","STE7 family","CAMK-like (CAMKL) family","ABC1 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Mitogen-activated protein kinas
es (MAP kinases)","Voltage-gated potassium channels","DMPK family","Coronavirus (CoV) proteins","STE11 family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-
related kinases (PIKK) family","Myosin Light Chain Kinase (MLCK) family","Vaccina related kinase (VRK) family","Protein kinase N (PKN) family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine
 kinases (nRTKs)","RAF family","Receptor interacting protein kinase (RIPK) family","KHS subfamily","MSN subfamily","LIM domain kinase (LISK) family","Receptor serine/threonine kinase (RSTK) family","P
olo-like kinase (PLK) family","QIK subfamily","Numb-associated kinase (NAK) family","Interleukin-1 receptor-associated kinase (IRAK) family","ABC1-B subfamily","TAO subfamily","Dyrk2 subfamily","p38 s
ubfamily","SLK subfamily","nmo subfamily","WEE family","MST subfamily","Unc-51-like kinase (ULK) family","NKF1 family","GEK subfamily","Mixed Lineage Kinase (MLK) family","STE20 subfamily","NIMA (neve
r in mitosis gene a)- related kinase (NEK) family","Aurora kinase (Aur) family","YSK subfamily","PEK family","FRAP subfamily","NKF4 family","Type XIII RTKs: Ephrin receptor family","Type I RTKs: ErbB 
(epidermal growth factor) receptor family","Src family","Abl family","Tec family","Csk family","Type XIV RTKs: RET","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","TESK subfamily","Type V RTKs
: FGF (fibroblast growth factor) receptor family","Janus kinase (JakA) family","Type I receptor serine/threonine kinases","LIMK subfamily","Type II receptor serine/threonine kinases","Type XVI RTKs: D
DR (collagen receptor) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","MLK subfamily","TAK1 subfamily","Syk family","GCN2 subfamily","LZK subfamily","Ack family","HH
498 subfamily","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Fer family"}

> <pathway_reactome>
{"Developmental Biology","Neuronal System",Disease,"Signal Transduction","Cell Cycle","Immune System","Gene expression (Transcription)","Cellular responses to external stimuli",Metabolism,"Cell-Cell c
ommunication","Vesicle-mediated transport","Extracellular matrix organization","Muscle contraction","Programmed Cell Death","Circadian Clock",Hemostasis,"Nervous system development","Transmission acro
ss Chemical Synapses","Infectious disease","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"MAPK family signaling ca
scades","Innate Immune System","RNA Polymerase II Transcription","Cellular responses to stress","Metabolism of lipids","Cell junction organization","Signaling by GPCR","Cytokine Signaling in Immune sy
stem","Signaling by TGFB family members","Signaling by NODAL","Membrane Trafficking","Non-integrin membrane-ECM interactions","Intracellular signaling by second messengers","Signaling by WNT","Cardiac
 conduction","Signaling by Hippo","Cell Cycle Checkpoints",Apoptosis,"Signaling by Non-Receptor Tyrosine Kinases","Signaling by Hedgehog","Signaling by Rho GTPases","Adaptive Immune System","Platelet 
activation","signaling and aggregation","Axon guidance","Neurotransmitter receptors and postsynaptic signal transmission","HIV Infection","Signaling by NTRKs","Leishmania infection","Oncogenic MAPK si
gnaling","Mitotic G2-G2/M phases","MAPK1/MAPK3 signaling","Toll-like Receptor Cascades","Signaling by PDGFR in disease","Generic Transcription Pathway","Cellular Senescence","Phospholipid metabolism",
"Cell-extracellular matrix interactions","GPCR downstream signalling","Signaling by FGFR in disease","Signaling by KIT in disease","Interferon Signaling","Signaling by BMP","Regulation of signaling by
 NODAL","trans-Golgi Network Vesicle Budding","PIP3 activates AKT signaling","GPCR ligand binding","Beta-catenin independent WNT signaling","Signaling by Insulin receptor","Phase 3 - rapid repolarisat
ion","Mitotic G1 phase and G1/S transition","Neutrophil degranulation","Signaling by VEGF","Fc epsilon receptor (FCERI) signaling","Signaling by Interleukins","Ion homeostasis","SARS-CoV Infections","
G2/M Checkpoints","Signaling by TGF-beta Receptor Complex in Cancer","Biosynthesis of specialized proresolving mediators (SPMs)","Apoptotic execution phase","Signaling by PTK6","Response of EIF2AK4 (G
CN2) to amino acid deficiency","Hedgehog 'on' state","M Phase","Regulation of mitotic cell cycle","RHO GTPase Effectors","TCR signaling","Metabolism of steroids","Response to elevated platelet cytosol
ic Ca2+","EPH-Ephrin signaling","Activation of NMDA receptors and postsynaptic events","Host Interactions of HIV factors","Signaling by NTRK1 (TRKA)","Parasite infection","Signaling by RAS mutants","G
2/M Transition","RAF/MAP kinase cascade","RET signaling","Toll Like Receptor 5 (TLR5) Cascade","Drug resistance of PDGFR mutants","Transcriptional regulation by RUNX1","Oxidative Stress Induced Senesc
ence","PI Metabolism","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","G alpha (q) signalling events","Semaphorin interactions","Signaling by FGFR1 in disease","Dr
ug resistance of KIT mutants","Interferon alpha/beta signaling","Golgi Associated Vesicle Biogenesis","Toll Like Receptor 2 (TLR2) Cascade","Negative regulation of the PI3K/AKT network","Class A/1 (Rh
odopsin-like receptors)","Leishmania parasite growth and survival","Signaling by FGFR2 in disease","Ca2+ pathway","Insulin receptor signalling cascade","G1 Phase","VEGF ligand-receptor interactions","
FCERI mediated Ca+2 mobilization",Interleukin-3,"Interleukin-5 and GM-CSF signaling","SARS-CoV-1 Infection","VEGFA-VEGFR2 Pathway","PTEN Regulation","G2/M DNA damage checkpoint","Loss of Function of S
MAD2/3 in Cancer","Toll Like Receptor 4 (TLR4) Cascade","Interleukin-2 family signaling","Transcriptional Regulation by TP53","Signaling by FGFR3 in disease","Interleukin-1 family signaling","Biosynth
esis of DHA-derived SPMs","Apoptotic cleavage of cellular proteins","Signaling by ROBO receptors","PTK6 Down-Regulation","Transcriptional Regulation by VENTX","Mitotic Metaphase and Anaphase","APC/C-m
ediated degradation of cell cycle proteins","Transcriptional Regulation by MECP2","RHO GTPases activate PKNs","Generation of second messenger molecules","Bile acid and bile salt metabolism","Platelet 
degranulation","L1CAM interactions","EPHB-mediated forward signaling","Post NMDA receptor activation events","The role of Nef in HIV-1 replication and disease pathogenesis","Signalling to ERKs","Leish
mania phagocytosis","EPHA-mediated growth cone collapse","Signaling downstream of RAS mutants","Centrosome maturation","Negative regulation of MAPK pathway","MyD88 cascade initiated on plasma membrane
","Imatinib-resistant PDGFR mutants","RUNX1 regulates transcription of genes involved in BCR signaling","Synthesis of PIPs at the plasma membrane","Gastrin-CREB signalling pathway via PKC and MAPK","S
ema4D in semaphorin signaling","FGFR1 mutant receptor activation","Dasatinib-resistant KIT mutants","Regulation of IFNA signaling","Toll Like Receptor TLR6:TLR2 Cascade",PI5P,"PP2A and IER3 Regulate P
I3K/AKT Signaling","Amine ligand-binding receptors","Anti-inflammatory response favouring Leishmania parasite infection","FGFR2 mutant receptor activation","IRS-mediated signalling","Cyclin D associat
ed events in G1","VEGF binds to VEGFR leading to receptor dimerization","SARS-CoV-1 Genome Replication and Transcription","VEGFR2 mediated cell proliferation","Regulation of PTEN stability and activit
y","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","SMAD2/3 Phosphorylation Motif Mutants in Cancer","MyD88-independent TLR4 cascade","Interleukin-15 signaling","Regulation of TP53 Ac
tivity","Signaling by FGFR3 point mutants in cancer","Interleukin-1 signaling","Biosynthesis of maresins","Role of ABL in ROBO-SLIT signaling","Cyclin A/B1/B2 associated events during G2/M transition"
,"Signalling to ERK5","Interleukin receptor SHC signaling","Mitotic Anaphase","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of MECP2 expression and activit
y","CRMPs in Sema3A signaling","Synthesis of bile acids and bile salts","Interaction between L1 and Ankyrins","Long-term potentiation","Nef-mediates down modulation of cell surface receptors by recrui
ting them to clathrin adapters","Signalling to RAS","FCGR3A-mediated phagocytosis","Loss of proteins required for interphase microtubule organization from the centrosome","Negative feedback regulation
 of MAPK pathway","MAP kinase activation","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone collapse","Signaling by activated point mutants of FGFR1","Prolonged ERK acti
vation events","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Serotonin receptors","FCGR3A-mediated IL10 synthesis","Activated point mutants of FGFR2","PI3K Cascade","Replication of the SARS
-CoV-1 genome","TRIF(TICAM1)-mediated TLR4 signaling","Nef and signal transduction","Regulation of TP53 Activity through Phosphorylation","FGFR3 mutant receptor activation","Biosynthesis of maresin-li
ke SPMs","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation","Separation of Sister Chromatids","APC/C:Cdc20 mediated degradation of mitotic proteins","Nuclear
 Envelope (NE) Reassembly","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","Nef Mediated CD4 Down-regulation","p38MAPK events","Loss of Nlp from mitotic centrosomes","activated 
TAK1 mediates p38 MAPK activation","Frs2-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 co
mplex","Signaling by activated point mutants of FGFR3","Regulation of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Initi
ation of Nuclear Envelope (NE) Reformation","Activation of the AP-1 family of transcription factors","APC-Cdc20 mediated degradation of Nek2A"}

> <broad_targets>
{ABL1,ABL2,BLK,EPHA2,FGR,FRK,FYN,HCK,KIT,LCK,LYN,PDGFRB,SRC,SRMS,STAT5B,YES1}

> <broad_moa>
{"Bcr-Abl kinase inhibitor","ephrin inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","SRC inhibitor","tyrosine kinase inhibitor"}

> <synonyms>
{Dasatinib,302962-49-8,302962498,Sprycel,BMS-354825,BMS354825,"BMS 354825","Dasatinib anhydrous","Dasatinib (anhydrous)","Dasatinib (BMS-354825)","Dasatinib (BMS354825)","anh. dasatinib",UNII-X78UG0A0
RN,UNIIX78UG0A0RN,"anhydrous dasatinib","dasatinib (anh.)",CHEMBL1421,X78UG0A0RN,CHEBI:49375,NSC732,T1448,T1448L,732517,S1021,"NSC 732517","Dasatinib monohydrate",dasatinib,DASATINIB}

> <pdid>
PD003446

> <targets>
{Abl/Src,c-Kit,Bcr-Abl,Src-bcr-Abl,SRC,Src,ABL,PDGFR,Apoptosis,Autophagy}

> <classes>
{BCR/ABL/Src inhibitor,Angiogenesis,Apoptosis,Autophagy,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{3062316}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
    6.4451   -1.8434    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -2.6017    2.9971    0.0000 O   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -2.6061    6.0003    0.0000 C   0  0
   -2.6061    7.5003    0.0000 C   0  0
   -1.3071    8.2503    0.0000 C   0  0
   -1.3071    9.7503    0.0000 C   0  0
   -0.0080    7.5003    0.0000 C   0  0
    1.2933    8.2481    0.0000 N   0  0
    2.5920    7.4959    0.0000 C   0  0
    3.8936    8.2414    0.0000 N   0  0
    5.1901    7.4869    0.0000 C   0  0
    5.1849    5.9869    0.0000 C   0  0
    3.8833    5.2414    0.0000 C   0  0
    2.5869    5.9958    0.0000 N   0  0
    3.8782    3.7406    0.0000 C   0  0
    5.1735    2.9840    0.0000 C   0  0
    5.1659    1.4840    0.0000 C   0  0
    3.8632    0.7406    0.0000 C   0  0
    2.5679    1.4971    0.0000 N   0  0
    2.5754    2.9971    0.0000 C   0  0
   -0.0080    6.0003    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988   -1.5004    0.0000 C   0  0
   -3.8983   -0.7513    0.0000 F   0  0
   -2.5983   -3.0004    0.0000 F   0  0
   -3.8975   -2.2510    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  4  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 24 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
 18 32  2  0
 32 13  1  0
  9 33  2  0
 33 34  1  0
 34 35  2  0
 35  7  1  0
 34 36  1  0
 36 37  1  0
 36 38  1  0
 36 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28441

> <plate>
Kinase v5-2

> <well>
G15

> <supplier_cmpd_name>
Nilotinib

> <ctcr_id>
1905

> <supplier_cmpd_id>
S1033

> <smiles>
Cc1cn(cn1)c2cc(NC(=O)c3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3)cc(c2)C(F)(F)F

> <pd_targets>
{ZAP70,DDR2,HCK,KCNH2,CA3,CA13,ABL1,BCR,STK10,NTRK2,MAPK10,RAF1,FGFR2,EPHB1,KIT,ABL2,EPHA3,TEK,CLK1,CSK,EPHA2,MAP3K20,SRC,PDGFRA,BLK,MAPK14,MAPK9,LYN,EPHB4,EPHA8,CLK4,BRAF,CA5A,CA4,JAK2,FLT3,DDR1,MAP2
K5,CA1,CA5B,CA2,CA9,CDC42BPB,FGR,PIP4K2C,MAP4K1,CSF1R,NTRK3,EPHA5,CDPK1,MAPK8,MAPK11,EPHB6,TIE1,RET,EPHA1,EPHA6,TAOK3,EPHB3,LCK,YES1,CA12,CA14,NQO2,TAOK1,CA6,MET,PDGFRB,EPHA4,FRK,CA7,CA15,EPHB2,TNNI3K
,MST1R,INSR,FYN,BMX,TYK2,FGFR1,CACNA1C,CACNA1D,CACNA1F,CACNA1S}

> <pathway_gtopdb>
{Enzyme,"Ion channel","Unclassified protein",Kinase,"Voltage-gated ion channel",Lyase,Transferase,Oxidoreductase,"Protein Kinase","Potassium channels","Voltage-gated calcium channel","TK protein kinas
e group","Voltage-gated potassium channel","Atypical protein kinase group","STE protein kinase group","CMGC protein kinase group","TKL protein kinase group","AGC protein kinase group","Tyrosine protei
n kinase Syk family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Abl family","Atypical protein kinase BCR family","STE protein kinase STE20 famil
y","Tyrosine protein kinase Trk family","CMGC protein kinase MAPK family","TKL protein kinase RAF family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase Eph family","Tyrosine protein k
inase PDGFR family","Tyrosine protein kinase Tie family","CMGC protein kinase CLK family","Tyrosine protein kinase Csk family","TKL protein kinase MLK family","Tyrosine protein kinase JakA family","ST
E protein kinase STE7 family","AGC protein kinase DMPK family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Met family","Tyrosine protein kinase InsR family","Tyrosine protein kinase 
Tec family","STE protein kinase SLK subfamily","CMGC protein kinase JNK subfamily","TKL protein kinase MLK subfamily","CMGC protein kinase p38 subfamily","AGC protein kinase GEK subfamily","STE protei
n kinase KHS subfamily","STE protein kinase TAO subfamily","TKL protein kinase HH498 subfamily","Tyrosine protein kinase SrcA"}

> <pathway_chembl>
{Receptors,"Ion channels",Enzymes,"Catalytic receptors","Voltage-gated ion channels","Carbonic anhydrases","Kinases (EC 2.7.x.x)","Receptor kinases","Potassium channels","STE: Homologs of yeast Steril
e 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","Lipid modifying kinases","TK: Tyrosine kinase","Voltage-gated potassium
 channels","STE20 family","Mitogen-activated protein kinases (MAP kinases)","TKL: Tyrosine kinase-like","CLK family","STE7 family","DMPK family","Type II PIP kinases (1-phosphatidylinositol-5-phosphat
e 4-kinase family)","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","SLK subfamily","JNK subfamily","RAF family","Mixed Lineage Kinase (MLK) family","p38 subfamily","GEK sub
family","KHS subfamily","TAO subfamily","Syk family","Type XVI RTKs: DDR (collagen receptor) family","Src family","Abl family","Type VII RTKs: Neurotrophin receptor/Trk family","Type V RTKs: FGF (fibr
oblast growth factor) receptor family","Type XIII RTKs: Ephrin receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Csk family
","MLK subfamily","Janus kinase (JakA) family","Type XIV RTKs: RET","Type X RTKs: HGF (hepatocyte growth factor) receptor family","HH498 subfamily","Type II RTKs: Insulin receptor family","Tec family"
}

> <pathway_reactome>
{"Immune System","Extracellular matrix organization",Disease,"Muscle contraction",Metabolism,"Signal Transduction","Developmental Biology","Gene expression (Transcription)","Transport of small molecul
es","Cell Cycle","Cellular responses to external stimuli","Adaptive Immune System","Non-integrin membrane-ECM interactions","Infectious disease","Cardiac conduction","Reversible hydration of carbon di
oxide","Innate Immune System","Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","Diseases of signal transduction by growth factor receptors and second messengers","Nervous syst
em development","RNA Polymerase II Transcription","O2/CO2 exchange in erythrocytes",Mitotic,"Cytokine Signaling in Immune system","Cellular responses to stress","Biological oxidations","Intracellular 
signaling by second messengers","Metabolism of lipids","TCR signaling","HIV Infection","Phase 3 - rapid repolarisation","Leishmania infection","Neutrophil degranulation","Signaling by NTRKs","Toll-lik
e Receptor Cascades","MAPK1/MAPK3 signaling","Signaling by FGFR in disease","Axon guidance","Signaling by KIT in disease","Oncogenic MAPK signaling","Signaling by PDGFR in disease","Generic Transcript
ion Pathway","Erythrocytes take up carbon dioxide and release oxygen","Mitotic G1 phase and G1/S transition","Signaling by Insulin receptor","Signaling by Interleukins","Cellular response to hypoxia",
"Phase I - Functionalization of compounds","M Phase","PIP3 activates AKT signaling","Signaling by MST1","Phospholipid metabolism","Interferon Signaling","Generation of second messenger molecules","Hos
t Interactions of HIV factors","Parasite infection","Signaling by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) Cascade","RAF/MAP kinase cascade","Signaling by FGFR2 in disease","EPH-Ephrin signaling","D
rug resistance of KIT mutants","Signaling by ROBO receptors","Signaling by RAS mutants","Drug resistance of PDGFR mutants","Transcriptional regulation by RUNX1","Leishmania parasite growth and surviva
l","G1 Phase","Insulin receptor signalling cascade","Interleukin-12 family signaling","Regulation of gene expression by Hypoxia-inducible Factor","Transcriptional Regulation by TP53","Transcriptional 
Regulation by VENTX","Signaling by NTRK3 (TRKC)","RET signaling","Mitotic Metaphase and Anaphase","Semaphorin interactions","Negative regulation of the PI3K/AKT network","PTEN Regulation","PI Metaboli
sm","Interferon alpha/beta signaling","Signaling by FGFR1 in disease","The role of Nef in HIV-1 replication and disease pathogenesis","Leishmania phagocytosis","Activation of TRKA receptors","MyD88 ca
scade initiated on plasma membrane","Negative regulation of MAPK pathway","FGFR2 mutant receptor activation","EPHB-mediated forward signaling","Dasatinib-resistant KIT mutants","Role of ABL in ROBO-SL
IT signaling","EPHA-mediated growth cone collapse","Signaling downstream of RAS mutants","Signalling to ERKs","Imatinib-resistant PDGFR mutants","RUNX1 regulates transcription of genes involved in BCR
 signaling","Anti-inflammatory response favouring Leishmania parasite infection","Cyclin D associated events in G1","IRS-mediated signalling","Signalling to ERK5","Interleukin-12 signaling","Regulatio
n of TP53 Activity","Activated NTRK3 signals through PI3K","Mitotic Anaphase","Sema4D in semaphorin signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Regulation of PTEN stability and activi
ty","Synthesis of PIPs at the plasma membrane","Regulation of IFNA signaling","FGFR1 mutant receptor activation","Nef and signal transduction","FCGR3A-mediated phagocytosis","NGF-independant TRKA acti
vation","MAP kinase activation","Negative feedback regulation of MAPK pathway","Activated point mutants of FGFR2","Signalling to RAS","FCGR3A-mediated IL10 synthesis","Prolonged ERK activation events"
,"PI3K Cascade","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Regulation of TP53 Activity through Acetylation","Nef-mediates down modulation of cell surface rec
eptors by recruiting them to clathrin adapters","Separation of Sister Chromatids","Sema4D mediated inhibition of cell attachment and migration","Signaling by activated point mutants of FGFR1","MAPK ta
rgets/ Nuclear events mediated by MAP kinases","p38MAPK events","ARMS-mediated activation","PI5P Regulates TP53 Acetylation","Nef Mediated CD4 Down-regulation","Activation of the AP-1 family of transc
ription factors"}

> <broad_targets>
{ABL1,KIT}

> <broad_moa>
{"Abl kinase inhibitor","Bcr-Abl kinase inhibitor"}

> <synonyms>
{Nilotinib,641571-10-0,641571100,Tasigna,AMN107,"AMN 107",AMN-107,Nilotinib(AMN-107),Nilotinib(AMN107),"Nilotinib (AMN-107)","Nilotinib (AMN107)","Nilotinib free base",UNII-F41401512X,UNIIF41401512X,C
HEMBL255863,C28H22F3N7O,CHEBI:52172,Nilotinib-d6,Nilotinibd6,"641571-10-0 (free base)","641571100 (free base)",MFCD09833716,NSC747599,F41401512X,T1524,747599,S1033,"NSC 747599",nilotinib,NILOTINIB}

> <pdid>
PD003312

> <targets>
{Src-bcr-Abl,BCR-ABL,SRC}

> <classes>
{"BCR-ABL/c-kit/PDGF inhibitor"}

> <pubchem_cids>
{644241}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  1  0            999 V2000
    3.8983   -0.7459    0.0000 O   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    1.2990    0.7500    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0  1  0  0  0
    0.0031    3.0008    0.0000 O   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    2.6160    7.4949    0.0000 O   0  0
    3.9072    5.2405    0.0000 C   0  0
    3.9020    3.7405    0.0000 C   0  0
    5.1976    2.9829    0.0000 C   0  0
    5.1903    1.4821    0.0000 C   0  0
    6.4859    0.7245    0.0000 C   0  0
    6.4808   -0.7755    0.0000 C   0  0
    7.7772   -1.5300    0.0000 C   0  0
    9.0789   -0.7845    0.0000 C   0  0
   10.3753   -1.5390    0.0000 O   0  0
    9.0841    0.7155    0.0000 C   0  0
    7.7877    1.4700    0.0000 C   0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0  2  0  0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0  2  0  0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  4  5  1  0
  5  6  1  6
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
  9 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 15  1  0
 12 22  2  0
 22  7  1  0
  5 23  1  0
 23 24  1  1
 23 25  1  0
 25 26  1  6
 25 27  1  0
 27  3  1  0
 27 28  1  1
M  END
> <name>
UTKinase_V5

> <id>
28442

> <plate>
Kinase v5-2

> <well>
G17

> <supplier_cmpd_name>
Quercetin(Sophoretin)

> <ctcr_id>
5940

> <supplier_cmpd_id>
S2391

> <smiles>
OC[C@H]1O[C@@H](Oc2cc(O)cc(\C=C\c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

> <pd_targets>
{MAPT,KDM4E,MAPK1,AKR1B1,PRKCZ,GAA,POLB}

> <pathway_gtopdb>
{"Other cytosolic protein","Epigenetic regulator",Enzyme,Eraser,Kinase,Oxidoreductase,Hydrolase,"Lysine demethylase","Protein Kinase","Jumonji domain-containing","CMGC protein kinase group","AGC prote
in kinase group","CMGC protein kinase MAPK family","AGC protein kinase PKC family","CMGC protein kinase ERK1","AGC protein kinase PKC iota subfamily"}

> <pathway_chembl>
{Enzymes,"Chromatin modifying enzymes","Kinases (EC 2.7.x.x)","1.-.-.- Oxidoreductases","3.2.1.- Glycosidases","1.14.11.- Histone demethylases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Co
ntaining PKA",PKG,"PKC families","Mitogen-activated protein kinases (MAP kinases)","Protein kinase C (PKC) family","ERK subfamily","Iota subfamily"}

> <pathway_reactome>
{"Neuronal System","Immune System",Metabolism,"Signal Transduction",Disease,"DNA Repair","Transmission across Chemical Synapses","Innate Immune System","Metabolism of lipids","Signaling by Nuclear Rec
eptors","Diseases of metabolism","Base Excision Repair","Neurotransmitter receptors and postsynaptic signal transmission","Toll-like Receptor Cascades","Metabolism of steroids","ESR-mediated signaling
","Diseases of carbohydrate metabolism","Resolution of Abasic Sites (AP sites)","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 5 (TLR5) Cascade","Metabolism of steroid horm
ones","Extra-nuclear estrogen signaling","Glycogen storage diseases","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","Post NMDA receptor activation events","MyD88 cascad
e initiated on plasma membrane","Pregnenolone biosynthesis","Estrogen-stimulated signaling through PRKCZ","Glycogen storage disease type II (GAA)","PCNA-Dependent Long Patch Base Excision Repair","Act
ivation of AMPK downstream of NMDARs","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{ICAM1}

> <broad_moa>
{"ICAM1 expression inhibitor"}

> <synonyms>
{Polydatin,Piceid,65914-17-2,65914172,"65914 17 2",Trans-Piceid,TransPiceid,"Trans Piceid",27208-80-6,27208806,"27208 80 6","3,4,5-Trihydroxystilbene-3-beta-monoglucoside","3,4,5Trihydroxystilbene3bet
amonoglucoside",3,4,"5 Trihydroxystilbene 3 beta",S2391,SAM001246720,Quercetin(Sophoretin),CPD000466371}

> <pdid>
PD001688

> <targets>
{"PI3K / PKC / Src-bcr-Abl",Apoptosis,Autophagy,Mitophagy}

> <classes>
{Apoptosis,Autophagy}

> <pubchem_cids>
{5281718}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 39  0  0  1  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6929   -4.0817    0.0000 C   0  0
    0.3385   -5.5341    0.0000 C   0  0
    1.4233   -6.5700    0.0000 C   0  0
    2.8629   -6.1484    0.0000 C   0  0
    3.2176   -4.6910    0.0000 C   0  0
    4.6570   -4.2662    0.0000 O   0  0
    5.0099   -2.8075    0.0000 C   0  0
    6.4493   -2.3827    0.0000 C   0  0
    6.8041   -0.9252    0.0000 C   0  0
    8.2436   -0.5037    0.0000 C   0  0
    9.3285   -1.5395    0.0000 C   0  0
    8.9738   -2.9970    0.0000 C   0  0
    7.5343   -3.4186    0.0000 C   0  0
    2.1327   -3.6551    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.8813   -1.4408    0.0000 C   0  0  1  0  0  0
   -4.7449   -0.2644    0.0000 C   0  0
   -5.9313   -1.1822    0.0000 C   0  0  1  0  0  0
   -5.0135   -2.3686    0.0000 C   0  0
   -7.4136   -0.9899    0.0000 C   0  0
   -7.9915    0.3952    0.0000 N   0  0
   -9.4418    0.7246    0.0000 C   0  0
   -9.5602    2.2199    0.0000 C   0  0
   -8.1746    2.7945    0.0000 C   0  0
   -7.1999    1.6544    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 14 23  2  0
 23 10  1  0
  9 24  1  0
 24  2  1  0
 24  6  2  0
 25  7  1  6
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 25  1  0
 27 29  1  1
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28443

> <plate>
Kinase v5-2

> <well>
G19

> <supplier_cmpd_name>
NVP-ADW742

> <ctcr_id>
7100

> <supplier_cmpd_id>
S1088

> <smiles>
Nc1ncnc2n(cc(c3cccc(OCc4ccccc4)c3)c12)[C@H]5C[C@@H](C5)CN6CCCC6

> <pd_targets>
{IGF1R,INSR,KIT,AURKA,FLT3,FLT1,CHEK2,PRKD2,RPS6KB1,MARK3,MARK2,CDC42BPA,LIMK1,KDR,LCK,FGFR1,ERBB4,BLK,SRC,STK3,CSNK1D,ROCK2,FLT4,LYN,ROCK1,PLK4,CSF1R,PRKCD,AURKB,NEK2,ACVR1,PDPK1,PIK3CG,FGFR4,EGFR,PD
GFRA,FGFR2,RET,GSC2,KCNH2,BTK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase InsR family","Other protein kinase group","CAMK protein kinase group","AGC protein kinase group","TKL protein kinase 
group","STE protein kinase group","CK1 protein kinase group","Tyrosine protein kinase PDGFR family","Other protein kinase AUR family","Tyrosine protein kinase VEGFR family","CAMK protein kinase RAD53 
family","CAMK protein kinase PKD family","AGC protein kinase RSK family","CAMK protein kinase CAMK1 family","AGC protein kinase DMPK family","TKL protein kinase LISK family","Tyrosine protein kinase S
rc family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase EGFR family","STE protein kinase STE20 family","CK1 protein kinase CK1 family","Other protein kinase PLK family","AGC protein 
kinase PKC family","Other protein kinase NEK family","AGC protein kinase p70 subfamily","CAMK protein kinase MARK subfamily","AGC protein kinase GEK subfamily","TKL protein kinase LIMK subfamily","STE
 protein kinase MST subfamily","AGC protein kinase ROCK subfamily","AGC protein kinase PKC delta subfamily","Ion channel",Transferase,"Voltage-gated ion channel","Potassium channels","Voltage-gated po
tassium channel","TKL protein kinase STKR family","AGC protein kinase PDK1 subfamily","Tyrosine protein kinase Ret family","Tyrosine protein kinase Tec family","TKL protein kinase STKR1"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type II RTKs: Insulin receptor family",Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmo
dulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","Other protein kinases","CAMK-like
 (CAMKL) family","Protein kinase D (PKD) family","RSK family","DMPK family","TKL: Tyrosine kinase-like","STE20 family","Casein kinase 1 (CK1) family","Protein kinase C (PKC) family","Aurora kinase (Au
r) family","CHK1 subfamily","p70 subfamily","MARK subfamily","GEK subfamily","LIM domain kinase (LISK) family","Non-receptor tyrosine kinases (nRTKs)","MST subfamily","Rho kinase","Polo-like kinase (P
LK) family","Delta subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth fact
or) receptor family","LIMK subfamily","Src family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Ion channels","Voltage-g
ated ion channels","Lipid modifying kinases","Potassium channels","PDK1 family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Voltage-gated potassium channels","Receptor serine/threonine ki
nase (RSTK) family","Type I receptor serine/threonine kinases","Type XIV RTKs: RET","Tec family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Intracellular signaling by second messengers","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","PIP3 activates AKT s
ignaling","IGF1R signaling cascade","Negative regulation of the PI3K/AKT network","IRS-related events triggered by IGF1R",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling",Disease,"Gene expression (Tra
nscription)",Metabolism,"Developmental Biology","Neuronal System","Cell Cycle","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Met
abolism of lipids","MTOR signalling","Nervous system development","Infectious disease","Transmission across Chemical Synapses","Signaling by Hippo",Mitotic,"Signaling by KIT in disease","Generic Trans
cription Pathway","Signaling by Insulin receptor","Signaling by VEGF","Sphingolipid metabolism","mTORC1-mediated signalling","Oncogenic MAPK signaling","Axon guidance","HIV Infection","Signaling by FG
FR in disease","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by NTRKs","Mitotic G2-G2/M phases","Leishmania infection","DAG and IP3 signaling","M Phase","Regulation of m
itotic cell cycle","Drug resistance of KIT mutants","Transcriptional Regulation by TP53","Insulin receptor signalling cascade","VEGF ligand-receptor interactions","Sphingolipid de novo biosynthesis","
Signaling by RAS mutants","Semaphorin interactions","VEGFA-VEGFR2 Pathway","Host Interactions of HIV factors","Signaling by FGFR1 in disease","Activation of NMDA receptors and postsynaptic events","Tr
anscriptional regulation by RUNX1","Signaling by NTRK1 (TRKA)","G2/M Transition","Leishmania parasite growth and survival","Transcriptional Regulation by VENTX","CaM pathway","Mitotic Metaphase and An
aphase","APC/C-mediated degradation of cell cycle proteins","Dasatinib-resistant KIT mutants","Regulation of TP53 Activity","IRS-mediated signalling","VEGF binds to VEGFR leading to receptor dimerizat
ion","Signaling downstream of RAS mutants","Sema4D in semaphorin signaling","VEGFR2 mediated cell proliferation","The role of Nef in HIV-1 replication and disease pathogenesis","FGFR1 mutant receptor 
activation","Post NMDA receptor activation events","RUNX1 regulates transcription of genes involved in BCR signaling","Signalling to ERKs","Centrosome maturation","Anti-inflammatory response favouring
 Leishmania parasite infection","Calmodulin induced events","Mitotic Anaphase","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Phosp
horylation","PI3K Cascade","Regulation of TP53 Expression and Degradation","Sema4D induced cell migration and growth-cone collapse","Nef-mediates down modulation of cell surface receptors by recruitin
g them to clathrin adapters","Signaling by activated point mutants of FGFR1","Long-term potentiation","Signalling to RAS","Loss of proteins required for interphase microtubule organization from the ce
ntrosome","FCGR3A-mediated IL10 synthesis","Separation of Sister Chromatids","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Degradation","Nef Mediated CD4 Down-regulation",
"p38MAPK events","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","APC-Cdc20 mediated degradation of Nek
2A","Muscle contraction","Signaling by GPCR","Cardiac conduction","Phospholipid metabolism","Signaling by FGFR","GPCR downstream signalling","Signaling by PDGFR in disease","Phase 3 - rapid repolarisa
tion","PI Metabolism","Signaling by FGFR4","G alpha (q) signalling events","Drug resistance of PDGFR mutants","Signaling by FGFR2 in disease","RET signaling","Parasite infection","Synthesis of PIPs at
 the plasma membrane","Downstream signaling of activated FGFR4","Gastrin-CREB signalling pathway via PKC and MAPK","Imatinib-resistant PDGFR mutants","FGFR2 mutant receptor activation","Leishmania pha
gocytosis","FRS-mediated FGFR4 signaling","EGFR Transactivation by Gastrin","Activated point mutants of FGFR2","FCGR3A-mediated phagocytosis"}

> <broad_targets>
{IGF1R,INSR}

> <broad_moa>
{"IGF-1 inhibitor"}

> <synonyms>
{NVP-ADW742,NVPADW742,475488-23-4,475488234,ADW-742,ADW742,475489-15-7,475489157,UNII-MXS2N5862L,UNIIMXS2N5862L,CHEMBL399021,cis-NVP-ADW742,cisNVPADW742,"GSK 621659A",MXS2N5862L,C28H31N5O,GSK-552602A,
GSK552602A,Kinome_2540,Kinome2540,Kinome-2540,"Kinome 2540",SCHEMBL95142,cc-532,cc532,"NVP ADW 742",NVP-ADW742/,NVPADW742/,SCHEMBL1983470,SCHEMBL1983472,CHEMBL1988370,DTXSI,S1088}

> <pdid>
PD003523

> <targets>
{NULL,IGF-1R}

> <classes>
{}

> <pubchem_cids>
{9825149}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 45  0  0  0  0            999 V2000
   10.0511  -14.7351    0.0000 C   0  0
    9.4065  -13.3807    0.0000 C   0  0
    7.9112  -13.2621    0.0000 C   0  0
    8.5560  -14.6162    0.0000 C   0  0
   10.2555  -12.1461    0.0000 C   0  0
   11.7550  -12.1072    0.0000 O   0  0
   12.1813  -10.6691    0.0000 N   0  0
   10.9460   -9.8410    0.0000 C   0  0
   10.9040   -8.3408    0.0000 N   0  0
    9.5842   -7.6262    0.0000 C   0  0
    8.3064   -8.4119    0.0000 O   0  0
    9.5422   -6.1260    0.0000 N   0  0
    8.2224   -5.4114    0.0000 C   0  0
    8.1783   -3.9120    0.0000 C   0  0
    6.8578   -3.2005    0.0000 C   0  0
    5.5861   -3.9865    0.0000 C   0  0
    5.6255   -5.4877    0.0000 C   0  0
    6.9460   -6.1992    0.0000 C   0  0
    4.2151   -3.3761    0.0000 C   0  0
    3.9032   -1.9089    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4990    0.7409    0.0000 N   0  0
   -7.8007    1.4864    0.0000 C   0  0
   -9.0971    0.7319    0.0000 C   0  0
   -9.0919   -0.7681    0.0000 O   0  0
   -7.7903   -1.5136    0.0000 C   0  0
   -6.4939   -0.7591    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 S   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.9160   -4.1261    0.0000 N   0  0
    9.7551  -10.7320    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 16 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 29  1  0
 25 35  1  0
 35 36  2  0
 36 22  1  0
 36 37  1  0
 37 38  1  0
 38 21  1  0
 38 39  2  0
 39 19  1  0
  8 40  1  0
 40  5  2  0
M  END
> <name>
UTKinase_V5

> <id>
28444

> <plate>
Kinase v5-2

> <well>
G21

> <supplier_cmpd_name>
AC-220

> <ctcr_id>
5565

> <supplier_cmpd_id>
S1526

> <smiles>
CC(C)(C)c1onc(NC(=O)Nc2ccc(cc2)c3cn4c5ccc(OCCN6CCOCC6)cc5sc4n3)c1

> <pd_targets>
{EPHA3,EPHA6,MKNK2,MAP3K7,PDGFRB,RET,MAPK15,FRK,HIPK4,STK10,NTRK2,FLT1,FLT3,KIT,PDGFRA,KDR,DDR1,MAP4K4,NTRK1,RIPK1,RIPK2,CSF1R,NTRK3,MAP3K19,EPHA7,SLK,ABL1,FLT4,MUSK,MYLK,LYN,DDR2,EPHB6,MAP4K5,TNIK,LC
K,MYLK3,TIE1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","TK protein kinase group","CAMK protein kinase group","TKL protein kinase group","CMGC protein kinase group","STE protein kinase group","Tyrosine
 protein kinase Eph family","CAMK protein kinase MAPKAPK family","TKL protein kinase MLK family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Ret family","CMGC protein kinase MAPK f
amily","Tyrosine protein kinase Src family","CMGC protein kinase DYRK family","STE protein kinase STE20 family","Tyrosine protein kinase Trk family","Tyrosine protein kinase VEGFR family","Tyrosine pr
otein kinase DDR family","TKL protein kinase RIPK family","STE protein kinase STE11 family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Musk family","CAMK protein kinase MLCK family"
,"Tyrosine protein kinase Tie family","CAMK protein kinase MNK subfamily","TKL protein kinase TAK1 subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase SLK subfamily","STE protein kinas
e MSN subfamily","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs o
f yeast Sterile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","MAPK-Activated Protein Kinase (MAPKAPK) family","TKL: Tyrosine kinase-like","Mitogen-activated protein kinases (MAP kinases)
","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","STE20 family","Myosin Light Chain Kinase (MLCK) family","Receptor tyrosine kinases (RTKs)","MKN subfamily","Mixed Line
age Kinase (MLK) family","Erk7 subfamily","Non-receptor tyrosine kinases (nRTKs)","HIPK subfamily","SLK subfamily","MSN subfamily","Receptor interacting protein kinase (RIPK) family","STE20 subfamily"
,"KHS subfamily","Type XIII RTKs: Ephrin receptor family","TAK1 subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIV RTKs: RET","Src family","Type VII RTKs: Neurotrophin recepto
r/Trk family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Abl family","Type IX RTKs: MuSK","Type XII RTKs: TIE family of 
angiopoietin receptors"}

> <pathway_reactome>
{"Developmental Biology","Immune System","Signal Transduction",Disease,"Extracellular matrix organization","Cellular responses to external stimuli","Gene expression (Transcription)","Nervous system de
velopment","Innate Immune System","Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messeng
ers","Non-integrin membrane-ECM interactions","Cellular responses to stress","RNA Polymerase II Transcription","Infectious disease","ECM proteoglycans","Signaling by Rho GTPases","Axon guidance","Toll
-like Receptor Cascades","PIP3 activates AKT signaling","Neutrophil degranulation","Signaling by NTRKs","Signaling by VEGF","Signaling by Insulin receptor","Signaling by KIT in disease","Signaling by 
PDGFR in disease","Cellular Senescence","Generic Transcription Pathway","Leishmania infection","RHO GTPase Effectors","HIV Infection","EPH-Ephrin signaling","Toll Like Receptor 4 (TLR4) Cascade","Nega
tive regulation of the PI3K/AKT network","RET signaling","PTEN Regulation","Signaling by NTRK1 (TRKA)","VEGF ligand-receptor interactions","Insulin receptor signalling cascade","Drug resistance of KIT
 mutants","Drug resistance of PDGFR mutants","VEGFA-VEGFR2 Pathway","Oxidative Stress Induced Senescence","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional Regulation by VENTX","Signaling by NTRK
3 (TRKC)","Parasite infection","RHO GTPases activate PAKs","Leishmania parasite growth and survival","Host Interactions of HIV factors","EPHA-mediated growth cone collapse","MyD88-independent TLR4 cas
cade",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Regulation of PTEN stability and activity","Activation of TRKA receptors","VEGF binds to VEGFR leading to receptor dimerization","IRS-mediated s
ignalling","Dasatinib-resistant KIT mutants","Imatinib-resistant PDGFR mutants","VEGFR2 mediated cell proliferation","Signalling to ERKs","MyD88 cascade initiated on plasma membrane","Activated NTRK3 
signals through PI3K","Leishmania phagocytosis","Anti-inflammatory response favouring Leishmania parasite infection","EPHB-mediated forward signaling","The role of Nef in HIV-1 replication and disease
 pathogenesis","TRIF(TICAM1)-mediated TLR4 signaling","NGF-independant TRKA activation","PI3K Cascade","Prolonged ERK activation events","MAP kinase activation","FCGR3A-mediated phagocytosis","FCGR3A-
mediated IL10 synthesis","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","TRAF6-mediated induction of TAK1 complex within TLR4 complex","ARMS-mediated 
activation","IKK complex recruitment mediated by RIP1","activated TAK1 mediates p38 MAPK activation","Nef Mediated CD4 Down-regulation"}

> <broad_targets>
{CSF1R,FLT3,KIT,PDGFRA,PDGFRB,RET}

> <broad_moa>
{"FLT3 inhibitor"}

> <synonyms>
{HY-13001,HY13001,Quizartinib,950769-58-1,950769581,AC220,"Quizartinib (AC220)",AC-220,"AC 220","Quizartinib HCl",UNII-7LA4O6Q0D3,UNII7LA4O6Q0D3,"Quizartinib freebase","AC 010220",AC010220,7LA4O6Q0D3,
CHEMBL576982,CHEBI:90217,ASP-2689,ASP2689,"950769-58-1 (free base)","950769581 (free base)",113282,T2066,S1526,quizartinib}

> <pdid>
PD003221

> <targets>
{FLT-3,Flt,FLT3,Apoptosis,Autophagy,"Ligand for Target Protein for PROTAC"}

> <classes>
{Angiogenesis,Apoptosis,Autophagy,PROTAC,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{24889392}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 45  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 N   0  0
   -3.9099   -8.2497    0.0000 C   0  0
   -3.9099   -9.7497    0.0000 C   0  0
   -2.6109  -10.4997    0.0000 C   0  0
   -1.3119   -9.7497    0.0000 C   0  0
   -1.3118   -8.2497    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2997    3.7504    0.0000 N   0  0
    1.3021    5.2504    0.0000 C   0  0
    2.6024    5.9984    0.0000 C   0  0
    3.9002    5.2463    0.0000 N   0  0
    3.8978    3.7463    0.0000 C   0  0
    2.5976    2.9984    0.0000 C   0  0
    5.2027    5.9920    0.0000 C   0  0
    5.2077    7.4920    0.0000 O   0  0
    6.5002    5.2377    0.0000 N   0  0
    7.8027    5.9834    0.0000 C   0  0
    9.1006    5.2313    0.0000 C   0  0
   10.4008    5.9793    0.0000 C   0  0
   10.4032    7.4793    0.0000 C   0  0
   11.7026    8.2303    0.0000 O   0  0
   11.7029    9.7311    0.0000 C   0  0
   13.0016   10.4817    0.0000 C   0  0
   10.4038   10.4809    0.0000 C   0  0
    9.1054    8.2313    0.0000 C   0  0
    7.8051    7.4834    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 13  1  0
  6 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22  5  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 23  1  0
 26 29  1  0
 29 30  2  0
 29 31  1  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 37 39  1  0
 35 40  1  0
 40 41  2  0
 41 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28445

> <plate>
Kinase v5-2

> <well>
I03

> <supplier_cmpd_name>
Tandutinib (MLN518)

> <ctcr_id>
4148

> <supplier_cmpd_id>
S1043

> <smiles>
COc1cc2c(cc1OCCCN3CCCCC3)ncnc2N4CCN(CC4)C(=O)Nc5ccc(OC(C)C)cc5

> <pd_targets>
{EGFR,CDK16,CLK1,NTRK1,PDGFRA,AURKC,PDGFRB,KIT,FLT3,ACVR1,STK10,HIPK4,PLK4,SRC,IRAK1,EPHB6,IRAK3,GAK,CDK7,KDR,SLK,CLK3,MERTK,MAP4K5,FLT4,FLT1,DDR1,AURKB,NTRK2,NTRK3,CLK4,CSF1R,LCK,DDR2,MAP2K5,CDKL2,AX
L,FGFR1,FGFR2,FGFR3,FGFR4,CLK2,MAP3K19,ITK,PDGFD}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","Other protein kinase group","TKL protein kinase group","STE protein kinase group","Tyrosin
e protein kinase EGFR family","CMGC protein kinase CDK family","CMGC protein kinase CLK family","Tyrosine protein kinase Trk family","Tyrosine protein kinase PDGFR family","Other protein kinase AUR fa
mily","TKL protein kinase STKR family","STE protein kinase STE20 family","CMGC protein kinase DYRK family","Other protein kinase PLK family","Tyrosine protein kinase Src family","TKL protein kinase IR
AK family","Other protein kinase NAK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Axl family","Tyrosine protein kinase DDR family","STE protein kinase STE7 family","CMGC pro
tein kinase CDKL family","Tyrosine protein kinase FGFR family","STE protein kinase STE11 family","Tyrosine protein kinase Tec family","CMGC protein kinase TAIRE subfamily","TKL protein kinase STKR1","
STE protein kinase SLK subfamily","CMGC protein kinase HIPK subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",
"TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","CLK family","Other protein kinases","TKL: Tyrosine kinase-like","STE20 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated ki
nase (DYRK) family","STE7 family","Cyclin-dependent kinase-like (CDKL) family","Receptor tyrosine kinases (RTKs)","TAIRE subfamily","Aurora kinase (Aur) family","Receptor serine/threonine kinase (RSTK
) family","SLK subfamily","HIPK subfamily","Polo-like kinase (PLK) family","Non-receptor tyrosine kinases (nRTKs)","Interleukin-1 receptor-associated kinase (IRAK) family","Numb-associated kinase (NAK
) family","CDK7 subfamily","KHS subfamily","STE20 subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type III RTKs: PDGFR",CSFR
,Kit,"FLT3 receptor family","Type I receptor serine/threonine kinases","Src family","Type XIII RTKs: Ephrin receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","
Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Tec family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System","Cell Cycle","Developmental Biology","Vesicle-mediated transport",Hemostasis,"Extracellular matrix organization","Gene expression (Transcription)","Signa
ling by GPCR","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Intracellular signaling by second messengers","Innate Immune 
System",Mitotic,"Nervous system development","Membrane Trafficking","Infectious disease","Cell surface interactions at the vascular wall","Non-integrin membrane-ECM interactions","RNA Polymerase II Tr
anscription","Adaptive Immune System","GPCR downstream signalling","Signaling by NTRKs","Signaling by PDGFR in disease","PIP3 activates AKT signaling","Signaling by KIT in disease","Signaling by Insul
in receptor","Neutrophil degranulation","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Axon guidance","trans-Golgi Network Vesicle Budding","HIV Infection","Signaling by VEGF","M Phase","Gene
ric Transcription Pathway","TCR signaling","Signaling by PDGF","G alpha (q) signalling events","Signaling by NTRK1 (TRKA)","Drug resistance of PDGFR mutants","Negative regulation of the PI3K/AKT netwo
rk","Drug resistance of KIT mutants","Insulin receptor signalling cascade","G2/M Transition","Toll Like Receptor 5 (TLR5) Cascade","EPH-Ephrin signaling","Toll Like Receptor 2 (TLR2) Cascade","Golgi A
ssociated Vesicle Biogenesis","HIV Life Cycle","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","Mitotic Metaphase and Anaphase","Signaling by NTRK3 (TRKC)","Transcriptional Regulation by VE
NTX","Host Interactions of HIV factors","Generation of second messenger molecules","Gastrin-CREB signalling pathway via PKC and MAPK","Signalling to ERKs","Imatinib-resistant PDGFR mutants",PI5P,"PP2A
 and IER3 Regulate PI3K/AKT Signaling","Dasatinib-resistant KIT mutants","IRS-mediated signalling","Centrosome maturation","MyD88 cascade initiated on plasma membrane","EPHB-mediated forward signaling
","Toll Like Receptor TLR6:TLR2 Cascade","Late Phase of HIV Life Cycle","VEGFR2 mediated cell proliferation","VEGF binds to VEGFR leading to receptor dimerization","Mitotic Anaphase","Activation of TR
KA receptors","Activated NTRK3 signals through PI3K","The role of Nef in HIV-1 replication and disease pathogenesis","Signalling to ERK5","EGFR Transactivation by Gastrin","Prolonged ERK activation ev
ents","PI3K Cascade","Loss of proteins required for interphase microtubule organization from the centrosome","Signalling to RAS","MAP kinase activation","MyD88:MAL(TIRAP) cascade initiated on plasma m
embrane","Transcription of the HIV genome","Separation of Sister Chromatids","NGF-independant TRKA activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin ad
apters","ARMS-mediated activation","Loss of Nlp from mitotic centrosomes","p38MAPK events","activated TAK1 mediates p38 MAPK activation","HIV Transcription Elongation","Nef Mediated CD4 Down-regulatio
n","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{CSF1R,FLT3,KIT,PDGFD,PDGFRB}

> <broad_moa>
{"FLT3 inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor"}

> <synonyms>
{Tandutinib,387867-13-2,387867132,MLN-518,MLN518,CT53518,"Tandutinib (MLN518)","MLN 518","CT 53518",UNII-E1IO3ICJ9A,UNIIE1IO3ICJ9A,CT-53518,E1IO3ICJ9A,CHEMBL124660,CHEBI:90237,MLN-0518,MLN0518,MFCD099
54147,NCGC00241097-01,NCGC0024109701,D06005,DSSTox_CID_28873,DSSToxCID28873,DSSTox-CID-28873,"DSSTox CID 28873",DSSTox_RID_83142,DSSToxRID83142,DSSTox-RID-83142,"DSSTox RID 83142",DSST,T1667,S1043,tan
dutinib,TANDUTINIB}

> <pdid>
PD003630

> <targets>
{FLT-3,KIT,PDGFR,FLT3,Apoptosis,c-Kit}

> <classes>
{Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{3038522}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
   -3.7793  -11.3955    0.0000 O   0  0
   -4.2401   -9.9681    0.0000 C   0  0
   -5.7077   -9.6537    0.0000 N   0  0
   -6.7155  -10.7648    0.0000 C   0  0
   -8.1816  -10.4476    0.0000 C   0  0
   -8.6399   -9.0193    0.0000 N   0  0
   -7.6322   -7.9083    0.0000 C   0  0
   -6.1661   -8.2254    0.0000 C   0  0
   -3.2334   -8.8550    0.0000 C   0  0
   -1.7662   -9.1671    0.0000 C   0  0
   -0.7624   -8.0525    0.0000 C   0  0
   -1.2256   -6.6258    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6928   -6.3138    0.0000 C   0  0
   -3.6967   -7.4283    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  2  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  3
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 15  2  0
 23 18  1  0
 12 24  1  0
 24 25  2  0
 25  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28446

> <plate>
Kinase v5-2

> <well>
I05

> <supplier_cmpd_name>
KW 2449

> <ctcr_id>
6245

> <supplier_cmpd_id>
S2158

> <smiles>
O=C(N1CCNCC1)c2ccc(C=Cc3[nH]nc4ccccc34)cc2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{ABL1,AURKA,AURKB,FLT3}

> <broad_moa>
{"Abl kinase inhibitor","Aurora kinase inhibitor","FLT3 inhibitor"}

> <synonyms>
{(E)-(4-(2-(1H-Indazol-3-yl)vinyl)-phenyl)(piperazin-1-yl)methanone,(E)(4(2(1HIndazol3yl)vinyl)phenyl)(piperazin1yl)methanone,(4-(2-(1H-indazol-3-yl)ethenyl)phenyl)-(1-piperazinyl)methanone,(4(2(1Hind
azol3yl)ethenyl)phenyl)(1piperazinyl)methanone,CHEMBL3184303,HMS3655N04,HMS3672K17,AKOS026750435,NCGC00346569-01,NCGC0034656901,DB-058275,DB058275,FT-0771733,FT0771733,Q27163287,(4-(2-(1H-indazol-3-y,
(4(2(1Hindazol3y,S2158,"KW 2449",KW-2449}

> <pdid>

> <targets>
{FLT3,Bcr-Abl,FLT-3,"Aurora Kinase"}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{67089852}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    7.7884    1.5181    0.0000 F   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8994   -3.7478    0.0000 O   0  0
   -5.1981   -2.9955    0.0000 C   0  0
   -6.4993   -3.7433    0.0000 C   0  0
   -7.7980   -2.9910    0.0000 C   0  0
   -9.0993   -3.7387    0.0000 N   0  0
  -10.3984   -2.9888    0.0000 C   0  0
  -11.6975   -3.7388    0.0000 C   0  0
  -11.6975   -5.2388    0.0000 O   0  0
  -10.3985   -5.9888    0.0000 C   0  0
   -9.0994   -5.2388    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0049   -5.9994    0.0000 C   0  0
    1.3026   -5.2471    0.0000 O   0  0
    0.0080   -7.5002    0.0000 C   0  0
    1.3081   -8.2484    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    5.1852    3.0091    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
 13 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  2  0
 24 30  1  0
 30 31  2  0
 31  7  1  0
 31 11  1  0
  5 32  1  0
 32 33  2  0
 33  2  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28447

> <plate>
Kinase v5-2

> <well>
I07

> <supplier_cmpd_name>
CI-1033(Canertinib)

> <ctcr_id>
896

> <supplier_cmpd_id>
S1019

> <smiles>
Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl

> <pd_targets>
{KIT,RIOK1,TXK,MKNK1,TEC,TGFBR1,TGFBR2,ABL1,SIK2,BLK,EGFR,LYN,MAP3K20,ABL2,EPHA4,EPHA8,SRMS,YES1,ERBB4,EPHA1,MAP3K4,MAP2K1,FLT1,BMP2K,MAP4K5,BMX,SRC,BTK,LCK,RIPK2,GAK,ITK,FLT3,CTSC,ERBB2,HCK,MINK1,PDG
FRB,SLK,MAPK4,IRAK3,EPHB1,MAPK9,EPHA3,AURKB,AURKC,STK36,FGR,PTK6,JAK3,MAP3K19,LRRK2,AXL,FRK,MKNK2,MAP3K3,STK17B,EPHB6,STK35,CSNK1D,TYRO3,COQ8B,TESK1,CIT,TNNI3K,EPHA5,MAPK6,COQ8A,ERBB3,DYRK2,MAP4K2,ACV
R1,MAPK14,RET,RPS6KA1,MAP3K2,LTK,FYN,EPHB2,MAPK10,STK10,EPHA6,DDR1,EPHA7,MET,PDGFRA,TIE1,ALK,TUBA1A,DYRK1A,MAP2K5,EPHB4,IRAK4,CSNK1E,CSK,MAP2K2,ULK3,HUNK,BMPR1B,HIPK4,IRAK1,MAP3K7,DMPK,STK17A,TNIK,MAP
2K7,SIK3}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Structural protein",Kinase,Protease,"Protein Kinase","Cysteine protease","TK protein kinase group","Atypical protein kinase group","CAMK protein kinase group","TKL prot
ein kinase group","STE protein kinase group","Other protein kinase group","Cysteine protease CA clan","CMGC protein kinase group","CK1 protein kinase group","AGC protein kinase group","Tyrosine protei
n kinase PDGFR family","Atypical protein kinase RIO family","Tyrosine protein kinase Tec family","CAMK protein kinase MAPKAPK family","TKL protein kinase STKR family","Tyrosine protein kinase Abl fami
ly","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Src family","Tyrosine protein kinase EGFR family","TKL protein kinase MLK family","Tyrosine protein kinase Eph family","STE protein kina
se STE11 family","STE protein kinase STE7 family","Tyrosine protein kinase VEGFR family","Other protein kinase NAK family","STE protein kinase STE20 family","TKL protein kinase RIPK family","Cysteine 
protease C1A family","CMGC protein kinase MAPK family","TKL protein kinase IRAK family","Other protein kinase AUR family","Other protein kinase ULK family","Tyrosine protein kinase JakA family","TKL p
rotein kinase LRRK family","Tyrosine protein kinase Axl family","CAMK protein kinase DAPK family","Other protein kinase NKF4 family","CK1 protein kinase CK1 family","Atypical protein kinase ABC1 famil
y","TKL protein kinase LISK family","AGC protein kinase DMPK family","CMGC protein kinase DYRK family","Tyrosine protein kinase Ret family","AGC protein kinase RSK family","Tyrosine protein kinase Alk
 family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Met family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Csk family","Atypical protein kinase RIO1 subfamily","C
AMK protein kinase MNK subfamily","TKL protein kinase STKR Type 1 subfamily","TKL protein kinase STKR Type 2 subfamily","CAMK protein kinase QIK subfamily","TKL protein kinase MLK subfamily","Tyrosine
 protein kinase Srm","STE protein kinase KHS subfamily","STE protein kinase MSN subfamily","STE protein kinase SLK subfamily","CMGC protein kinase ERK3","CMGC protein kinase JNK subfamily","STE protei
n kinase MEKK2","Atypical protein kinase ABC1-A subfamily","TKL protein kinase TESK subfamily","AGC protein kinase CRIK subfamily","TKL protein kinase HH498 subfamily","CMGC protein kinase Dyrk2 subfa
mily","TKL protein kinase STKR1","CMGC protein kinase p38 subfamily","AGC protein kinase RSK subfamily","Tyrosine protein kinase SrcA","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase HIPK s
ubfamily","TKL protein kinase TAK1 subfamily","AGC protein kinase GEK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Peptidases and proteinases",Tubulins,"Receptor kinases",Atypical,"CAMK: Calcium/calmodulin-dependent protein ki
nases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CA: Cysteine (C) Peptidases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","AGC: Containing PKA",P
KG,"PKC families","TK: Tyrosine kinase","RIO family","MAPK-Activated Protein Kinase (MAPKAPK) family","TKL: Tyrosine kinase-like","CAMK-like (CAMKL) family","STE11 family","STE7 family","Other protein
 kinases","STE20 family","C1: Papain","Mitogen-activated protein kinases (MAP kinases)","Death-associated kinase (DAPK) family","Casein kinase 1 (CK1) family","ABC1 family","DMPK family","Dual-specifi
city tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","RSK family","Receptor tyrosine kinases (RTKs)","RIO1 subfamily","Non-receptor tyrosine kinases (nRTKs)","MKN subfamily","Receptor ser
ine/threonine kinase (RSTK) family","QIK subfamily","Mixed Lineage Kinase (MLK) family","Numb-associated kinase (NAK) family","KHS subfamily","Receptor interacting protein kinase (RIPK) family","MSN s
ubfamily","SLK subfamily","ERK subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","JNK subfamily","Aurora kinase (Aur) family","Unc-51-like kinase (ULK) family","STE20 subfamily","Leu
cine-rich repeat kinase (LRRK) family","NKF4 family","ABC1-B subfamily","LIM domain kinase (LISK) family","Other DMPK family kinases","Dyrk2 subfamily","p38 subfamily","RSK subfamily","Dyrk1 subfamily
","HUNK subfamily","HIPK subfamily","GEK subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Tec family","Type I receptor serine/threonine kinases","Type II receptor serine/threonine ki
nases","Abl family","Src family","Type I RTKs: ErbB (epidermal growth factor) receptor family","MLK subfamily","Type XIII RTKs: Ephrin receptor family","Type IV RTKs: VEGF (vascular endothelial growth
 factor) receptor family","Janus kinase (JakA) family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","TESK subfamily","HH498 subfamily","Type XIV RTKs: RET","Type XIX RTKs: Leukocyte 
tyrosine kinase (LTK) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptor
s","Csk family","TAK1 subfamily"}

> <pathway_reactome>
{Disease,"Metabolism of RNA","Immune System","Signal Transduction","Gene expression (Transcription)","Developmental Biology","Neuronal System",Metabolism,"Vesicle-mediated transport","Metabolism of pr
oteins","Cellular responses to external stimuli","Cell Cycle","Cell-Cell communication","Extracellular matrix organization","Muscle contraction","Diseases of signal transduction by growth factor recep
tors and second messengers","rRNA processing","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Cytokine Signaling in Immune system","Infectious disease","RNA Polymerase II Transcriptio
n","Signaling by GPCR","Nervous system development","Signaling by Non-Receptor Tyrosine Kinases","Transmission across Chemical Synapses","Metabolism of lipids","Membrane Trafficking","Adaptive Immune 
System","Post-translational protein modification","Cellular responses to stress","Intracellular signaling by second messengers","MAPK family signaling cascades",Mitotic,"Cell junction organization","S
ignaling by Rho GTPases","Non-integrin membrane-ECM interactions","Signaling by Hedgehog","Signaling by TGFB family members","Cardiac conduction","Signaling by KIT in disease","rRNA processing in the 
nucleus and cytosol","Fc epsilon receptor (FCERI) signaling","Signaling by FGFR","Signaling by Interleukins","Signaling by TGF-beta Receptor Complex in Cancer","Leishmania infection","Generic Transcri
ption Pathway","GPCR downstream signalling","Axon guidance","Signaling by PTK6","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by NTRKs","Signaling by VEGF","Phospholipid
 metabolism","HIV Infection","Toll-like Receptor Cascades","trans-Golgi Network Vesicle Budding","TCR signaling","Signaling by Insulin receptor","Asparagine N-linked glycosylation","Cellular Senescenc
e","PIP3 activates AKT signaling","MAPK6/MAPK4 signaling","M Phase","Mitotic G1 phase and G1/S transition","Mitotic G2-G2/M phases","Cell-extracellular matrix interactions","RHO GTPase Effectors","Neu
trophil degranulation","Signaling by PDGFR in disease","Oncogenic MAPK signaling","Hedgehog 'on' state","Signaling by BMP","Ion homeostasis","Drug resistance of KIT mutants","Major pathway of rRNA pro
cessing in the nucleolus and cytosol","FCERI mediated Ca+2 mobilization","Signaling by FGFR4",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Loss of Function of SMAD2/3 in Cancer","Parasite infec
tion","Transcriptional regulation by RUNX1","G alpha (q) signalling events","Leishmania parasite growth and survival","Signaling by ROBO receptors","EPH-Ephrin signaling","PTK6 Down-Regulation","Activ
ation of NMDA receptors and postsynaptic events","Signaling by NTRK1 (TRKA)","VEGF ligand-receptor interactions","PI Metabolism","Host Interactions of HIV factors","Toll Like Receptor 5 (TLR5) Cascade
","Golgi Associated Vesicle Biogenesis","Generation of second messenger molecules","Insulin receptor signalling cascade","Transport to the Golgi and subsequent modification","Semaphorin interactions",
"Oxidative Stress Induced Senescence","Negative regulation of the PI3K/AKT network","Toll Like Receptor 2 (TLR2) Cascade","Mitotic Metaphase and Anaphase","G1 Phase","Interleukin-2 family signaling","
PTK6 promotes HIF1A stabilization","VEGFA-VEGFR2 Pathway","PTEN Regulation","Interleukin-1 family signaling","G2/M Transition","Regulation of cytoskeletal remodeling and cell spreading by IPP complex 
components","RHO GTPases activate CIT","Transcriptional Regulation by TP53","RET signaling","Drug resistance of PDGFR mutants","G0 and Early G1","Signaling by RAS mutants","Toll Like Receptor 4 (TLR4)
 Cascade","Dasatinib-resistant KIT mutants","Negative regulation of FGFR4 signaling","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Leishmania phagocytosis","RUNX1 regulates transcription of genes
 involved in BCR signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Anti-inflammatory response favouring Leishmania parasite infection","Role of ABL in ROBO-SLIT signaling","EPHA-mediated 
growth cone collapse","Post NMDA receptor activation events","Signalling to ERKs","VEGF binds to VEGFR leading to receptor dimerization","Synthesis of PIPs at the plasma membrane","The role of Nef in 
HIV-1 replication and disease pathogenesis","MyD88 cascade initiated on plasma membrane","IRS-mediated signalling","ER to Golgi Anterograde Transport","Sema4D in semaphorin signaling",PI5P,"PP2A and I
ER3 Regulate PI3K/AKT Signaling","Toll Like Receptor TLR6:TLR2 Cascade","EPHB-mediated forward signaling","Mitotic Anaphase","Cyclin D associated events in G1","Interleukin-15 signaling","Regulation o
f PTEN stability and activity","Interleukin-1 signaling","Centrosome maturation","Regulation of TP53 Activity","Imatinib-resistant PDGFR mutants","Signalling to ERK5","Signaling downstream of RAS muta
nts","MyD88-independent TLR4 cascade","Spry regulation of FGF signaling","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","FCGR3A-mediated IL10 synthesis","Long-term potentiation","Pro
longed ERK activation events","Signalling to RAS","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","MAP kinase activation","PI3K Cascade","Cargo concent
ration in the ER","Sema4D induced cell migration and growth-cone collapse","Nef and signal transduction","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Separation of Sister Chromatids","Loss
 of proteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Activity through Phosphorylation","Sema4D mediated inhibition of cell attachment and migration","
TRIF(TICAM1)-mediated TLR4 signaling","Frs2-mediated activation","p38MAPK events","Nef Mediated CD4 Down-regulation","activated TAK1 mediates p38 MAPK activation","MAPK targets/ Nuclear events mediate
d by MAP kinases","Loss of Nlp from mitotic centrosomes","TRAF6-mediated induction of TAK1 complex within TLR4 complex","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human
 TAK1","Activation of the AP-1 family of transcription factors","CREB phosphorylation"}

> <broad_targets>
{AKT1,EGFR,ERBB2,ERBB4}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{I1033(CANERTINIB,Canertinib,267243-28-7,267243287,CI-1033,CI1033,"Canertinib (CI-1033)","Canertinib (CI1033)",UNII-C78W1K5ASF,UNIIC78W1K5ASF,PD-183805,PD183805,"Canertinib free base",C78W1K5ASF,CHEMB
L31965,CHEBI:61399,"267243-28-7 (free base)","267243287 (free base)",NCGC00182713-01,NCGC0018271301,CI-1033(Canertinib),CI1033(Canertinib),"Canertinib (INN:BAN)",PubCh,T2501,T6136,S1019,"Canertinib di
hydrochloride",canertinib,CANERTINIB}

> <pdid>
PD003440

> <targets>
{HER2,HER1/2/4}

> <classes>
{}

> <pubchem_cids>
{156414}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 38  0  0  0  0            999 V2000
    6.4833   -9.7648    0.0000 C   0  0
    6.4855   -8.2648    0.0000 O   0  0
    5.1873   -7.5117    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    6.4897   -5.2632    0.0000 O   0  0
    3.8912   -5.2578    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.6011   -3.0008    0.0000 N   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -7.8061   -5.9891    0.0000 O   0  0
   -7.8091   -7.4899    0.0000 C   0  0
   -9.1082   -8.2400    0.0000 C   0  0
   -9.1082   -9.7400    0.0000 C   0  0
   -7.8091  -10.4900    0.0000 C   0  0
   -7.8091  -11.9900    0.0000 C   0  0
   -6.5101   -9.7400    0.0000 N   0  0
   -6.5101   -8.2400    0.0000 C   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -7.7966   -2.9860    0.0000 C   0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 27 29  1  0
 29 30  2  0
 30 24  1  0
 22 31  1  0
 31 32  1  0
 31 33  2  0
 33 19  1  0
 17 34  1  0
 34 13  1  0
 34 35  2  0
 35 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28448

> <plate>
Kinase v5-2

> <well>
I09

> <supplier_cmpd_name>
CP-724714

> <ctcr_id>
7098

> <supplier_cmpd_id>
S1167

> <smiles>
COCC(=O)NC/C=C/c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1

> <pd_targets>
{ERBB2,EGFR,MKNK2,CDK8,TUBA1A,CDK19}

> <pathway_gtopdb>
{Enzyme,"Structural protein",Kinase,"Protein Kinase","TK protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Tyrosine protein kinase EGFR family","CAMK protein kinase MAPKAP
K family","CMGC protein kinase CDK family","CAMK protein kinase MNK subfamily","CMGC protein kinase CDK8 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)",Tubulins,"Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK
3,"CLK families","TK: Tyrosine kinase","MAPK-Activated Protein Kinase (MAPKAPK) family","Cyclin-dependent kinase (CDK) family","Receptor tyrosine kinases (RTKs)","MKN subfamily","CDK8 subfamily","Type
 I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction",Disease,"Cell Cycle",Metabolism,"Nervous system development","Signaling by GPCR","Diseases of signal transduction by growth factor receptors and second m
essengers",Mitotic,"Metabolism of lipids","Axon guidance","GPCR downstream signalling","Signaling by NOTCH1 in Cancer","Mitotic G2-G2/M phases","Regulation of lipid metabolism by PPARalpha","Semaphori
n interactions","G alpha (q) signalling events","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","G2/M Transition","PPARA activates gene expression","Sema4D in semaphorin signaling","Gastrin-CRE
B signalling pathway via PKC and MAPK","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Centrosome maturation","Sema4D induced cell migration and growth-cone collapse","EGFR Transactivation 
by Gastrin","Loss of proteins required for interphase microtubule organization from the centrosome","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{ERBB2}

> <broad_moa>
{"EGFR inhibitor","protein tyrosine kinase inhibitor"}

> <synonyms>
{CP-724714,CP724714,383432-38-0,383432380,"CP 724714","CP-724,714","CP724,714",UNII-I05QZ0S4V3,UNIII05QZ0S4V3,CHEMBL483321,I05QZ0S4V3,845680-17-3,845680173,C27H27N5O3,SCHEMBL95109,cc-593,cc593,MLS0060
11185,GTPL7883,SCHEMBL4617807,BDBM31340,CHEBI:91331,cid_9874913,cid9874913,cid-9874913,"cid 9874913",SYN1033,CHEBI:167658,BCPP000275,BCP0184,T4014,S1167}

> <pdid>
PD003239

> <targets>
{HER2,EGFR}

> <classes>
{}

> <pubchem_cids>
{9874913}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 35  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 O   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 C   0  0
   -5.2081    5.9890    0.0000 N   0  0
   -5.2112    7.4898    0.0000 C   0  0
   -3.9134    8.2421    0.0000 O   0  0
   -6.5120    8.2384    0.0000 N   0  0
   -6.5150    9.7392    0.0000 C   0  0
   -7.8140   10.4893    0.0000 C   0  0
   -7.8140   11.9893    0.0000 C   0  0
   -6.5150   12.7393    0.0000 C   0  0
   -6.5150   14.2393    0.0000 Cl  0  0
   -5.2160   11.9893    0.0000 C   0  0
   -5.2160   10.4893    0.0000 C   0  0
   -3.9162   12.7397    0.0000 C   0  0
   -3.9153   14.2397    0.0000 F   0  0
   -2.6174   11.9893    0.0000 F   0  0
   -2.6168   13.4891    0.0000 F   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -5.1985    2.9859    0.0000 F   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 22 23  2  0
 23 17  1  0
 22 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
 12 28  1  0
 28 29  1  0
 28 30  2  0
 30  9  1  0
  7 31  2  0
 31 32  1  0
 32 33  2  0
 33  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28449

> <plate>
Kinase v5-2

> <well>
I11

> <supplier_cmpd_name>
BAY 73-4506(Regorafenib)

> <ctcr_id>
4826

> <supplier_cmpd_id>
S1178

> <smiles>
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1

> <pd_targets>
{PDGFRB,RET,GLRA1,TEK,RAF1,KDR,KIT,BRAF,FLT4,EPHX2,FLT1,FGFR1,FLT3,PDGFRA,DDR2,FRK,FGFR2,MAPK11,ABL1,NTRK1,EPHA2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Ligand-gated ion channel",Protease,"Protein Kinase","Glycine receptor","Serine protease","TK protein kinase group","TKL protein kinase group","Serine protease SC clan","C
MGC protein kinase group","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Tie family","TKL protein kinase RAF family","Tyrosine protein kinase VEGF
R family","Serine protease S33 family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Src family","CMGC protein kinase MAPK family","Tyrosine prote
in kinase Abl family","Tyrosine protein kinase Trk family","Tyrosine protein kinase Eph family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Receptors,"Ion channels",Enzymes,"Catalytic receptors","Ligand-gated ion channels",Hydrolases,"Kinases (EC 2.7.x.x)","Receptor kinases","Glycine receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK famil
ies","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Mitogen-activated protein kinases (MAP kinases)","Receptor tyrosine kinases (RTKs)","RAF family","Non-receptor tyrosine kinases (nRTKs)","p38 su
bfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIV RTKs: RET","Type XII RTKs: TIE family of angiopoietin receptors","Type IV RTKs: VEGF (vascular endothelial growth factor) rece
ptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Src family","Abl family","Type VII RTKs: Neurotrophin receptor/Trk family","
Type XIII RTKs: Ephrin receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Neuronal System",Disease,Metabolism,"Extracellular matrix organization","Immune System","Intracellular signaling by second messengers","Nervous system d
evelopment","Transmission across Chemical Synapses","MAPK family signaling cascades","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second mes
sengers","Metabolism of lipids","Non-integrin membrane-ECM interactions","Innate Immune System","Infectious disease","PIP3 activates AKT signaling","Axon guidance","Neurotransmitter receptors and post
synaptic signal transmission","MAPK1/MAPK3 signaling","Signaling by VEGF","Signaling by KIT in disease","Signaling by NTRKs","Biosynthesis of specialized proresolving mediators (SPMs)","Signaling by F
GFR in disease","Signaling by Insulin receptor","Toll-like Receptor Cascades","Leishmania infection","Signaling by PDGFR in disease","Negative regulation of the PI3K/AKT network","RET signaling","RAF/
MAP kinase cascade","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","Signaling by NTRK1 (TRKA)","VEGF ligand-receptor interactions","Biosynthesis of DHA-derived SPMs","Signaling by FGFR1 in di
sease","Insulin receptor signalling cascade","PTEN Regulation","Signaling by FGFR2 in disease","Toll Like Receptor 5 (TLR5) Cascade","Parasite infection","Drug resistance of PDGFR mutants","EPH-Ephrin
 signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Negative regulation of MAPK pathway","VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","Signalling to ERKs","VEGF bin
ds to VEGFR leading to receptor dimerization","Biosynthesis of maresins","FGFR1 mutant receptor activation","IRS-mediated signalling","Regulation of PTEN stability and activity","FGFR2 mutant receptor
 activation","MyD88 cascade initiated on plasma membrane","Leishmania phagocytosis","Imatinib-resistant PDGFR mutants","EPHA-mediated growth cone collapse","Negative feedback regulation of MAPK pathwa
y","Prolonged ERK activation events","Signaling by activated point mutants of FGFR1","PI3K Cascade","Activated point mutants of FGFR2","MAP kinase activation","FCGR3A-mediated phagocytosis","ARMS-medi
ated activation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{ABL1,BRAF,DDR2,EPHA2,FGFR1,FGFR2,FLT1,FLT4,FRK,KDR,KIT,MAPK11,NTRK1,PDGFRA,PDGFRB,RAF1,RET,TEK}

> <broad_moa>
{"FGFR inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","RAF inhibitor","RET tyrosine kinase inhibitor","VEGFR inhibitor"}

> <synonyms>
{"EGORAFENIB (BAY 734506",Regorafenib,755037-03-7,755037037,"BAY 73-4506","BAY 734506",Stivarga,Regorafenibum,"Regorafenib (BAY 73-4506)","Regorafenib (BAY 734506)",BAY73-4506,BAY734506,BAY-73-4506,UN
II-24T2A1DOYB,UNII24T2A1DOYB,24T2A1DOYB,CHEMBL1946170,CHEBI:68647,"Stivarga (TN)","BAY73-4506 hydrochloride","BAY734506 hydrochloride",1255386-16-3,1255386163,Regor,T1792,763932,S1178,regorafenib,"BAY
 73-4506(Regorafenib)"}

> <pdid>
PD003518

> <targets>
{VEGFR-PDGFR,c-Kit,Raf,VEGFR,c-RET}

> <classes>
{"Protein Tyrosine Kinase","Kinase inhibitor"}

> <pubchem_cids>
{11167602}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 32  0  0  0  0            999 V2000
    1.3616    8.0780    0.0000 C   0  0
    1.5200    6.5864    0.0000 N   0  0
    2.8199    5.8378    0.0000 C   0  0
    2.4951    4.3865    0.0000 C   0  0
    1.0181    4.2118    0.0000 C   0  0
    0.4064    5.5814    0.0000 N   0  0
    3.4987    3.2707    0.0000 C   0  0
    4.9661    3.5819    0.0000 C   0  0
    5.9693    2.4667    0.0000 C   0  0
    5.5051    1.0403    0.0000 C   0  0
    6.2543   -0.2583    0.0000 N   0  0
    5.2500   -1.3725    0.0000 N   0  0
    3.8990   -0.7508    0.0000 C   0  0
    4.0377    0.7291    0.0000 N   0  0
    3.0345    1.8443    0.0000 N   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 F   0  0
    3.8975   -2.2510    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 10  1  0
 14 15  1  0
 15  7  2  0
 13 16  1  0
 16 17  1  0
 16 18  1  0
 16 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 22  1  0
 27 28  2  0
 28 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28450

> <plate>
Kinase v5-2

> <well>
I13

> <supplier_cmpd_name>
JNJ-38877605

> <ctcr_id>
6058

> <supplier_cmpd_id>
S1114

> <smiles>
Cn1cc(cn1)c2ccc3nnc(n3n2)C(F)(F)c4ccc5ncccc5c4

> <pd_targets>
{MET,PDE3A,PDE3B,TPR}

> <pathway_gtopdb>
{Enzyme,Kinase,Phosphodiesterase,"Protein Kinase","Phosphodiesterase 3","TK protein kinase group","Phosphodiesterase 3A","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Semaphorin interactions","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{MET}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{JNJ-38877605,JNJ38877605,943540-75-8,943540758,"JNJ 38877605",UNII-15UDG410PN,UNII15UDG410PN,15UDG410PN,C19H13F2N7,1072116-03-0,1072116030,PubChem22454,cc-51,cc51,MLS006010960,SCHEMBL182199,CHEMBL213
3806,CHEBI:91417,DTXSID20677253,QCR-226,QCR226,SYN1047,BDBM163243,HMS3244G09,HMS3244G10,HMS3244H09,T6095,S1114}

> <pdid>
PD011130

> <targets>
{c-Met}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{46911863}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 32  0  0  0  0            999 V2000
   14.0881   -4.9705    0.0000 O   0  0
   12.7176   -4.3608    0.0000 C   0  0
   11.5031   -5.2427    0.0000 C   0  0
   10.1342   -4.6338    0.0000 N   0  0
    8.8339   -5.3815    0.0000 C   0  0
    7.7422   -4.3714    0.0000 C   0  0
    8.3333   -3.0066    0.0000 C   0  0
    9.8249   -3.1660    0.0000 N   0  0
    6.2733   -4.6785    0.0000 C   0  0
    5.8050   -6.1036    0.0000 C   0  0
    4.3368   -6.4106    0.0000 N   0  0
    3.3368   -5.2925    0.0000 C   0  0
    1.8376   -5.2878    0.0000 N   0  0
    1.3788   -3.8597    0.0000 N   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8050   -3.8675    0.0000 C   0  0
    5.2733   -3.5605    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  4  1  0
  6  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 20  1  0
 25 26  2  0
 26 17  1  0
 15 27  1  0
 27 12  1  0
 27 28  2  0
 28  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28451

> <plate>
Kinase v5-2

> <well>
I15

> <supplier_cmpd_name>
PF-04217903

> <ctcr_id>
5606

> <supplier_cmpd_id>
S1094

> <smiles>
OCCn1cc(cn1)c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2

> <pd_targets>
{PDE3A,PDE3B,CYP2C9,MET,PDE5A,PDE10A}

> <pathway_gtopdb>
{Enzyme,Phosphodiesterase,"Cytochrome P450",Kinase,"Phosphodiesterase 3","Cytochrome P450 family 2","Protein Kinase","Phosphodiesterase 5","Phosphodiesterase 10","Phosphodiesterase 3A","Cytochrome P45
0 family 2C","TK protein kinase group","Phosphodiesterase 5A","Phosphodiesterase 3B","Phosphodiesterase 10A","Cytochrome P450 2C9","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Catalytic receptors","Cyclic nucleotide turnover/signalling","CYP2 family: drug metabolising subset","Receptor kinases",Phosphodiesterases,3',"5'-cyclic nucleotid
e (PDEs)","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{Metabolism,"Developmental Biology",Hemostasis,"Signal Transduction","Biological oxidations","Nervous system development","Platelet homeostasis","Signaling by Receptor Tyrosine Kinases","Phase I - Fun
ctionalization of compounds","Axon guidance","Nitric oxide stimulates guanylate cyclase","Signaling by Insulin receptor","Cytochrome P450 - arranged by substrate type","Semaphorin interactions","cGMP 
effects","Insulin receptor signalling cascade",Xenobiotics,"Sema4D in semaphorin signaling","IRS-mediated signalling","CYP2E1 reactions","Sema4D mediated inhibition of cell attachment and migration","
PI3K Cascade","PKB-mediated events","PDE3B signalling"}

> <broad_targets>
{MET}

> <broad_moa>
{"c-Met inhibitor"}

> <synonyms>
{F0421790,SMR004702763,AB0033686,FT-0700423,FT0700423,PF-04217903,PF04217903,956905-27-4,956905274,1159490-85-3,1159490853,"PF 04217903",UNII-CYJ9ATV1IJ,UNIICYJ9ATV1IJ,PF-4217903,PF4217903,CYJ9ATV1IJ,
CHEMBL2001019,"Met tyrosine kinase inhibitor PF-04217903","Met tyrosine kinase inhibitor PF04217903","956905-27-4 (free base)","956905274 (free base)","PF-04217903 (phenolsulfo","PF04217903 (phenolsul
fo",T2676,S1094}

> <pdid>
PD011144

> <targets>
{c-Met,c-MET}

> <classes>
{}

> <pubchem_cids>
{17754438}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  1  0            999 V2000
    3.8964    0.7545    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0  1  0  0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2121    3.8625    0.0000 C   0  0
    0.7463    5.2884    0.0000 N   0  0
   -0.7537    5.2860    0.0000 N   0  0
   -1.2149    3.8587    0.0000 C   0  0
   -1.6377    6.4987    0.0000 C   0  0
   -1.1355    7.9069    0.0000 C   0  0
   -2.1078    9.0491    0.0000 C   0  0
   -3.5831    8.7781    0.0000 N   0  0
   -4.0862    7.3650    0.0000 C   0  0
   -3.1139    6.2228    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2056   -2.9933    0.0000 C   0  0
    3.9091   -3.7478    0.0000 Cl  0  0
    6.5072   -3.7388    0.0000 C   0  0
    7.8036   -2.9844    0.0000 C   0  0
    9.1052   -3.7299    0.0000 F   0  0
    7.7985   -1.4844    0.0000 C   0  0
    6.4969   -0.7388    0.0000 C   0  0
    6.4918    0.7612    0.0000 Cl  0  0
  2  1  1  6
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
  6 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 11  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
  2 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  2  0
 29 22  1  0
 29 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28452

> <plate>
Kinase v5-2

> <well>
I17

> <supplier_cmpd_name>
PF-2341066

> <ctcr_id>
5753

> <supplier_cmpd_id>
S1068

> <smiles>
C[C@@H](Oc1cc(cnc1N)c2cnn(c2)C3CCNCC3)c4c(Cl)cc(F)cc4Cl

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NSC756645,NSC-756645,AB01273972-01,AB0127397201,756645,"NSC 756645",Crizotinib,PF-2341066}

> <pdid>
PD004074

> <targets>
{}

> <classes>
{"ALK inhibitor"}

> <pubchem_cids>
{54613769}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    7.7884    1.5181    0.0000 Cl  0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 C   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -3.8916    3.7585    0.0000 C   0  0
   -3.8864    5.2585    0.0000 C   0  0
   -2.5847    6.0040    0.0000 N   0  0
   -1.2883    5.2495    0.0000 C   0  0
   -1.2935    3.7495    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 10 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23  7  1  0
 23 18  1  0
  5 24  1  0
 24 25  2  0
 25  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28453

> <plate>
Kinase v5-2

> <well>
I19

> <supplier_cmpd_name>
Vatalanib

> <ctcr_id>
4984

> <supplier_cmpd_id>
S1101

> <smiles>
Clc1ccc(Nc2nnc(Cc3ccncc3)c4ccccc24)cc1

> <pd_targets>
{KDR,FLT4,FLT1,KIT,PDGFRA,CDK19,CIT,FRK,PDGFRB,RET,HLA-A,EGFR,PTK6,STK3,RPS6KB1,MAP3K20,DDR1,CDK8,CSF1R,MAP3K19}

> <pathway_gtopdb>
{Enzyme,"Surface antigen",Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","AGC protein kinase group","STE protein kinase group","TKL protein kinase group","Tyrosine prote
in kinase VEGFR family","Tyrosine protein kinase PDGFR family","CMGC protein kinase CDK family","AGC protein kinase DMPK family","Tyrosine protein kinase Src family","Tyrosine protein kinase Ret famil
y","Tyrosine protein kinase EGFR family","STE protein kinase STE20 family","AGC protein kinase RSK family","TKL protein kinase MLK family","Tyrosine protein kinase DDR family","STE protein kinase STE1
1 family","CMGC protein kinase CDK8 subfamily","AGC protein kinase CRIK subfamily","STE protein kinase MST subfamily","AGC protein kinase p70 subfamily","TKL protein kinase MLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Ster
ile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","DMPK family","STE20 family","RSK family","TKL: Tyrosine kinase-like","Receptor tyrosine kinases (
RTKs)","CDK8 subfamily","Other DMPK family kinases","Non-receptor tyrosine kinases (nRTKs)","MST subfamily","p70 subfamily","Mixed Lineage Kinase (MLK) family","STE20 subfamily","Type IV RTKs: VEGF (v
ascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Src family","Type XIV RTKs: RET","Type I RTKs: ErbB (epidermal growth factor) receptor famil
y","MLK subfamily","Type XVI RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Signal Transduction",Disease,Metabolism,"Developmental Biology","Immune System","Cell Cycle","Extracellular matrix organization","Gene expression (Transcription)","Signaling by Receptor Tyrosine Kin
ases","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","Signaling by Rho GTPases","Intracellular signaling by second messengers","Nervous syste
m development","Adaptive Immune System","Signaling by GPCR",Mitotic,"Signaling by Hippo","MTOR signalling","Non-integrin membrane-ECM interactions","RNA Polymerase II Transcription","Signaling by VEGF
","Signaling by KIT in disease","Signaling by PDGFR in disease","Regulation of lipid metabolism by PPARalpha","RHO GTPase Effectors","PIP3 activates AKT signaling","Axon guidance","Class I MHC mediate
d antigen processing & presentation","GPCR downstream signalling","Mitotic G1 phase and G1/S transition","mTORC1-mediated signalling","Signaling by NOTCH1 in Cancer","Generic Transcription Pathway","V
EGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","Drug resistance of KIT mutants","Drug resistance of PDGFR mutants","PPARA activates gene expression","RHO GTPases activate CIT","PTEN Regulati
on","Negative regulation of the PI3K/AKT network","RET signaling","Antigen processing-Cross presentation","G alpha (q) signalling events","G1 Phase","Signaling by NOTCH1 HD+PEST Domain Mutants in Canc
er","Transcriptional Regulation by VENTX","VEGFR2 mediated cell proliferation","VEGF binds to VEGFR leading to receptor dimerization","Dasatinib-resistant KIT mutants","Imatinib-resistant PDGFR mutant
s","Regulation of PTEN stability and activity",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Endosomal/Vacuolar pathway","Gastrin-CREB signalling pathway via PKC and MAPK","Cyclin D associated eve
nts in G1","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR,FLT1,FLT4,KDR,PDGFRB}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{RESTW135,Vatalanib,212141-54-3,212141543,"Vatalanib base",N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine,N(4chlorophenyl)4(pyridin4ylmethyl)phthalazin1amine,"Vatalanib free base",PTK787,
Pynasunate,Vatalinib,"CGP 79787",PTK-787,"Vatalanib (free base)",ZK-232934,ZK232934,CGP-79787,CGP79787,1-Phthalazinamine,1Phthalazinamine,N-(4-chloro,N(4chloro,T6720,Prestw-1358,"Vatalanib 2HCl",VATAL
ANIB}

> <pdid>
PD008695

> <targets>
{VEGFR-PDGFR,VEGFR,KIT,RET,FMS,PDGFR}

> <classes>
{}

> <pubchem_cids>
{151194}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 30  0  0  0  0            999 V2000
   11.5035   -5.2462    0.0000 C   0  0
   10.1342   -4.6338    0.0000 N   0  0
    8.8339   -5.3815    0.0000 C   0  0
    7.7422   -4.3714    0.0000 C   0  0
    8.3333   -3.0066    0.0000 C   0  0
    9.8249   -3.1660    0.0000 N   0  0
    6.2733   -4.6785    0.0000 C   0  0
    5.8050   -6.1036    0.0000 C   0  0
    4.3368   -6.4106    0.0000 C   0  0
    3.3368   -5.2925    0.0000 C   0  0
    1.8376   -5.2878    0.0000 N   0  0
    1.3788   -3.8597    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8050   -3.8675    0.0000 N   0  0
    5.2733   -3.5605    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 18  1  0
 23 24  2  0
 24 15  1  0
 13 25  1  0
 25 10  1  0
 25 26  1  0
 26  7  2  0
M  END
> <name>
UTKinase_V5

> <id>
28454

> <plate>
Kinase v5-2

> <well>
I21

> <supplier_cmpd_name>
SGX-523

> <ctcr_id>
1515

> <supplier_cmpd_id>
S1112

> <smiles>
Cn1cc(cn1)c2ccc3nnc(Sc4ccc5ncccc5c4)n3n2

> <pd_targets>
{MET,PIP4K2C,DYRK1A,MAP3K19,MAPK10,MAPK8,PDE3A,PDE3B,DYRK1B,ABL1}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,Phosphodiesterase,"Protein Kinase","Phosphodiesterase 3","TK protein kinase group","CMGC protein kinase group","STE protein kinase group","Phosphodiesterase 3A","Tyrosine pr
otein kinase Met family","CMGC protein kinase DYRK family","STE protein kinase STE11 family","CMGC protein kinase MAPK family","Tyrosine protein kinase Abl family","CMGC protein kinase Dyrk1 subfamily
","CMGC protein kinase JNK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","Lipid modifying kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile
 11","Sterile 20 kinases","TK: Tyrosine kinase","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family
","STE20 family","Mitogen-activated protein kinases (MAP kinases)","Receptor tyrosine kinases (RTKs)","Dyrk1 subfamily","STE20 subfamily","JNK subfamily","Non-receptor tyrosine kinases (nRTKs)","Type 
X RTKs: HGF (hepatocyte growth factor) receptor family","Abl family"}

> <pathway_reactome>
{"Developmental Biology","Gene expression (Transcription)","Cell Cycle","Immune System",Disease,"Nervous system development","RNA Polymerase II Transcription",Mitotic,"Innate Immune System","Infectiou
s disease","Axon guidance","Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","Toll-like Receptor Cascades","Leishmania infection","Semaphorin interactions","Transcriptional Regula
tion by TP53","G0 and Early G1","Toll Like Receptor 5 (TLR5) Cascade","Parasite infection","Sema4D in semaphorin signaling","Regulation of TP53 Activity","MyD88 cascade initiated on plasma membrane","
Leishmania phagocytosis","Sema4D mediated inhibition of cell attachment and migration","Regulation of TP53 Activity through Acetylation","MAP kinase activation","FCGR3A-mediated phagocytosis","PI5P Re
gulates TP53 Acetylation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MET}

> <broad_moa>
{"hepatocyte growth factor receptor inhibitor"}

> <synonyms>
{GX52,SGX-523,SGX523,FT-0697187,FT0697187,SW219713-1,SW2197131,X7475,EC-000.2355,EC000.2355,W-5657,W5657,J-518184,J518184,BRD-K19477839-001-01-9,BRDK19477839001019,Q27088796,"Met Kinase Inhibitor VI, 
SGX523 - CAS 1022150-57-7","Met Kinase Inhibitor VI, SGX523  CAS 1022150577",1022150-57-7,1022150577,"SGX 523",UNII-WH8SQN09KJ,UNIIWH8SQN09KJ,WH8SQN09KJ,CHEMBL1236107,CHEBI:90624,C18H13N7S,BDBM,T2293,
S1112}

> <pdid>
PD003219

> <targets>
{c-Met}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{24779724}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
   -6.5529  -10.5899    0.0000 C   0  0
   -5.0856  -10.2783    0.0000 N   0  0
   -4.0821  -11.3932    0.0000 C   0  0
   -2.6148  -11.0816    0.0000 C   0  0
   -2.1509   -9.6551    0.0000 N   0  0
   -3.1545   -8.5402    0.0000 C   0  0
   -4.6218   -8.8518    0.0000 C   0  0
   -0.6835   -9.3403    0.0000 C   0  0
    0.3219  -10.4535    0.0000 O   0  0
   -0.2222   -7.9149    0.0000 C   0  0
    1.2028   -7.4466    0.0000 C   0  0
    2.4192   -8.3243    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 N   0  0
   -1.3010    3.7516    0.0000 C   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -3.9027    5.2517    0.0000 C   0  0
   -5.2032    5.9990    0.0000 C   0  0
   -6.5007    5.2464    0.0000 C   0  0
   -6.4977    3.7464    0.0000 C   0  0
   -7.7952    2.9937    0.0000 Cl  0  0
   -5.1971    2.9990    0.0000 C   0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6079   -6.7003    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 16  1  0
 25 20  1  0
 23 26  1  0
 26 27  2  0
 26 28  2  0
 26 29  1  0
 29 30  1  0
 29 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  1  0
 35 37  2  0
 37 31  1  0
 14 38  2  0
 38 10  1  0
 38 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28455

> <plate>
Kinase v5-2

> <well>
K03

> <supplier_cmpd_name>
SU11274(PKI-SU11274)

> <ctcr_id>
4849

> <supplier_cmpd_id>
S1080

> <smiles>
CN1CCN(CC1)C(=O)c2c(C)[nH]c(C=C3C(=O)Nc4ccc(cc34)[S](=O)(=O)N(C)c5cccc(Cl)c5)c2C

> <pd_targets>
{PTK2B,RORC,MET,RECQL,CCNE1,CDK2,KMT2A,MEN1}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator",Kinase,"Nuclear receptor",Reader,"Protein Kinase","Nuclear hormone receptor subfamily 1",Bromodomain,"TK protein kinase group","Nuclear hormone re
ceptor subfamily 1 group F","CMGC protein kinase group","Tyrosine protein kinase Fak family","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase Met family","CMGC protein 
kinase CDK family","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Nuclear hormone receptors","Receptor kinases","1F. Retinoic acid-related orphans","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kin
ases (RTKs)","Fak family","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)","Developmental Biology","Cytokine Signaling in Immune system","RNA Polymerase II Transcription","Nervous system development","Signaling by Interleuki
ns","Generic Transcription Pathway","Axon guidance","Interleukin-2 family signaling","Transcriptional regulation by RUNX3","Semaphorin interactions","Interleukin-2 signaling","RUNX3 Regulates Immune R
esponse and Cell Migration","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{MET}

> <broad_moa>
{"hepatocyte growth factor receptor inhibitor","tyrosine kinase inhibitor"}

> <synonyms>
{U11274(PKISU11274,HMS3295E03,HMS3654C17,NCGC00165902-02,NCGC0016590202,FT-0700347,FT0700347,SW219453-1,SW2194531,Q27163250,T6154,"EMD 448101",S1080,SU11274,448101,SU11274(PKI-SU11274),"SU 11274"}

> <pdid>
PD003569

> <targets>
{c-Met,c-MET}

> <classes>
{}

> <pubchem_cids>
{53396327}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 46  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 N   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2089   -5.9859    0.0000 Cl  0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -5.1977   -2.9829    0.0000 N   0  0
   -5.1903   -1.4821    0.0000 C   0  0
   -3.8861   -0.7410    0.0000 C   0  0
   -3.8758    0.7590    0.0000 C   0  0
   -5.1696    1.5179    0.0000 C   0  0
   -6.4738    0.7769    0.0000 C   0  0
   -6.4841   -0.7230    0.0000 C   0  0
   -7.7891   -1.4644    0.0000 S   0  0
   -7.7990   -2.9644    0.0000 O   0  0
   -9.0929   -2.2060    0.0000 O   0  0
   -9.0841   -0.7058    0.0000 C   0  0
  -10.3883   -1.4467    0.0000 C   0  0
   -9.0741    0.7942    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 N   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 C   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -0.0072    7.5016    0.0000 N   0  0
    1.2895    8.2559    0.0000 C   0  0
    1.2847    9.7558    0.0000 C   0  0
   -0.0167   10.5017    0.0000 N   0  0
   -0.0215   12.0017    0.0000 C   0  0
   -1.3134    9.7476    0.0000 C   0  0
   -1.3086    8.2476    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 22 23  1  0
 23 24  2  0
 23 25  2  0
 23 26  1  0
 26 27  1  0
 26 28  1  0
 15 29  2  0
 29 10  1  0
  5 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 30  1  0
 33 36  1  0
 36 37  1  0
 37 38  1  0
 38 39  1  0
 39 40  1  0
 39 41  1  0
 41 42  1  0
 42 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28456

> <plate>
Kinase v5-2

> <well>
K05

> <supplier_cmpd_name>
NVP-TAE684

> <ctcr_id>
5097

> <supplier_cmpd_id>
S1108

> <smiles>
COc1cc(ccc1Nc2ncc(Cl)c(Nc3ccccc3[S](=O)(=O)C(C)C)n2)N4CCC(CC4)N5CCN(C)CC5

> <pd_targets>
{TEK,TXK,AURKA,RIOK3,CLK2,STK17B,BMPR1A,PLK1,PRKX,CSF1R,EGFR,EPHA1,FGR,PAK4,MAP4K1,BMPR1B,BTK,DAPK3,BLK,CLK1,MAPK12,MERTK,MAP3K10,PAK2,PRKACB,KDR,LIMK1,MAP3K11,EPHB4,TEC,CSK,HIPK4,CSNK1A1L,EPHA5,EIF2A
K4,MINK1,CAMK2B,CAMK4,FLT4,MARK3,NEK3,MAP2K4,MAP3K9,NEK7,MAPK1,MAPK9,MAP3K7,PTK2,PRKCD,LRRK2,FLT1,LYN,ZAP70,INSR,KIT,FES,SIK3,CDK17,CDK16,PRKAA2,CDC42BPA,PKN2,STK25,TNIK,TNNI3K,EPHB2,PAK5,TAOK1,PTK2B,
STK10,ABL2,PTK6,TYRO3,PLK4,STK38L,STK32B,MARK1,MAST1,KARS1,ABL1,FLT3,TNK2,ULK3,IRAK1,CSNK2A2,JAK1,PAK1,MAP2K3,NEK4,BRSK1,NEK9,SRMS,MAP2K5,CDK1,RET,RPS6KA1,DMPK,MST1R,ALK,RPS6KB1,ULK1,PLK3,MAP4K2,DCLK1
,CDK5,TIE1,YES1,MAP3K4,PRKAA1,IGF1R,AURKC,NEK2,PDGFRB,BRSK2,SYK,CLK3,EPHB3,RPS6KA3,TGFBR1,LATS1,RPS6KA6,NTRK1,PIP5K1A,CDK7,MAP2K6,EPHB1,MAP4K4,PRKG1,MET,JAK2,TYK2,LCK,PDGFRA,CAMK2D,DDR2,RPS6KA2,PHKG1,
PRKCQ,MAP3K2,PLK2,INSRR,MKNK2,FGFR4,COQ8B,MAP2K2,MAPK15,SIK1,OXSR1,PRKG2,MARK4,DAPK2,LATS2,STK26,MARK2,SLK,FGFR1,FGFR3,AURKB,STK16,CDK4,MAP3K15,CHEK2,ERBB2,STK4,CAMKK2,NUAK1,SIK2,PRKD2,SNRK,HIPK1,NIM1
K,ROCK1,ITK,LIMK2,DYRK1B,CAMKK1,COQ8A,IRAK4,TAOK2,BMP2K,CILK1,MYO3B,STK32A,ERN1,CDK2,FRK,PDPK1,PRKACA,MAPK7,MAPK8,ROS1,DCLK3,FYN,DSTYK,CDPK1,CAMK2A,EPHA6,CDC42BPG,ERBB4,ACVR1,CHEK1,AXL,SRPK1,CAMK2G,SB
K3,ROCK2,TGFBR2,STK24,MAP4K3,CAMK1,PRPF4B,TNK1,ACVR1B,EPHA7,EPHB6,MAP3K13,CDC42BPB,RPS6KA4,PHKG2,ACVRL1,HCK,PAK3,CASK,EPHA2,ANKK1,EPHA4,STK17A,SBK1,ACVR2A,PRKD1,MAP2K1,WEE1,SRC,EPHA3,JAK3,STK3,MAP4K5,
STK36,FGFR2,MAP3K19,MAPK14,CDK15,CAMK1D,CAMK1G,STK39,MATK,GRK1,STK35,GRK4,LTK,PKN1,GRK5,TSSK2,DAPK1,MYLK,BMX,MELK,CLK4,STK33,TSSK1B,PRKCE,GAK,MAP3K12,HIPK2,SRPK3,TAOK3,MYO3A,IKBKE,FER,MUSK,PRKD3,DDR1,
MAPK3,TTK,PKNB,MAP3K3,PI4KB,TBK1,HUNK,ULK2,RIPK4,NTRK2,MAP3K6,STK38,PIP4K2C,NEK6,PAK6,RIPK2,DCLK2,MAPK10,DYRK1A,ACVR2B,AAK1,IRAK3,HIPK3,MAP3K1,BMPR2,GRK7,NUAK2,STK32C,EML4}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,Transferase,"Protein Kinase","TK protein kinase group","Other protein kinase group","Atypical protein kinase group","CMGC protein kinase group","CAMK protein kina
se group","TKL protein kinase group","AGC protein kinase group","STE protein kinase group","CK1 protein kinase group","Tyrosine protein kinase Tie family","Tyrosine protein kinase Tec family","Other p
rotein kinase AUR family","Atypical protein kinase RIO family","CMGC protein kinase CLK family","CAMK protein kinase DAPK family","TKL protein kinase STKR family","Other protein kinase PLK family","AG
C protein kinase PKA family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Eph family","Tyrosine protein kinase Src family","STE protein kinase 
STE20 family","CMGC protein kinase MAPK family","Tyrosine protein kinase Axl family","TKL protein kinase MLK family","Tyrosine protein kinase VEGFR family","TKL protein kinase LISK family","Tyrosine p
rotein kinase Csk family","CMGC protein kinase DYRK family","CK1 protein kinase CK1 family","Other protein kinase PEK family","CAMK protein kinase CAMK2 family","CAMK protein kinase CAMK1 family","Oth
er protein kinase NEK family","STE protein kinase STE7 family","Tyrosine protein kinase Fak family","AGC protein kinase PKC family","TKL protein kinase LRRK family","Tyrosine protein kinase Syk family
","Tyrosine protein kinase InsR family","Tyrosine protein kinase Fer family","CMGC protein kinase CDK family","AGC protein kinase DMPK family","AGC protein kinase PKN family","Tyrosine protein kinase 
Abl family","AGC protein kinase NDR family","AGC protein kinase YANK family","AGC protein kinase MAST family","Tyrosine protein kinase Ack family","Other protein kinase ULK family","TKL protein kinase
 IRAK family","Other protein kinase CK2 family","Tyrosine protein kinase JakA family","Tyrosine protein kinase Ret family","AGC protein kinase RSK family","Tyrosine protein kinase Met family","CAMK pr
otein kinase DCAMK1 family","STE protein kinase STE11 family","Tyrosine protein kinase Trk family","AGC protein kinase PKG family","Tyrosine protein kinase DDR family","CAMK protein kinase PHk family"
,"CAMK protein kinase MAPKAPK family","Tyrosine protein kinase FGFR family","Atypical protein kinase ABC1 family","Other protein kinase NAK family","CAMK protein kinase RAD53 family","Other protein ki
nase CAMKK family","CAMK protein kinase PKD family","CMGC protein kinase RCK family","AGC protein kinase PDK1 subfamily","Tyrosine protein kinase Sev family","CMGC protein kinase SRPK family","Other p
rotein kinase NKF1 family","TKL protein kinase RIPK family","Other protein kinase WEE family","AGC protein kinase GRK family","Other protein kinase NKF4 family","Tyrosine protein kinase Alk family","C
AMK protein kinase TSSK family","CAMK protein kinase MLCK family","CAMK protein kinase unique family","Tyrosine protein kinase Musk family","Other protein kinase TTK family","Other protein kinase IKK 
family","Atypical protein kinase RIO3 subfamily","TKL protein kinase STKR Type 1 subfamily","STE protein kinase PAKB subfamily","STE protein kinase KHS subfamily","CMGC protein kinase p38 subfamily","
TKL protein kinase MLK subfamily","STE protein kinase PAKA subfamily","TKL protein kinase LIMK subfamily","CMGC protein kinase HIPK subfamily","CK1 protein kinase CK1-a","Other protein kinase GCN2 sub
family","STE protein kinase MSN subfamily","CAMK protein kinase MARK subfamily","Other protein kinase Nek1","CMGC protein kinase ERK1","CMGC protein kinase JNK subfamily","TKL protein kinase TAK1 subf
amily","AGC protein kinase PKC delta subfamily","CAMK protein kinase QIK subfamily","CMGC protein kinase PCTAIRE","CMGC protein kinase TAIRE subfamily","CAMK protein kinase AMPK subfamily","AGC protei
n kinase GEK subfamily","STE protein kinase YSK subfamily","TKL protein kinase HH498 subfamily","STE protein kinase TAO subfamily","STE protein kinase SLK subfamily","CAMK protein kinase BRSK subfamil
y","Tyrosine protein kinase Srm","CMGC protein kinase CDC2 subfamily","AGC protein kinase RSK subfamily","AGC protein kinase p70 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CD
K7 subfamily","STE protein kinase MEKK2","Other protein kinase PLK2","CAMK protein kinase MNK subfamily","Atypical protein kinase ABC1-A subfamily","STE protein kinase FRAY subfamily","STE protein kin
ase ASK","STE protein kinase MST subfamily","Other protein kinase Meta subfamily","CAMK protein kinase NuaK subfamily","CAMK protein kinase NIM1 subfamily","AGC protein kinase ROCK subfamily","CMGC pr
otein kinase Dyrk1 subfamily","CMGC protein kinase MAK","STE protein kinase NinaC subfamily","CMGC protein kinase ERK5","Tyrosine protein kinase SrcA","TKL protein kinase STKR1","CAMK protein kinase C
HK1 subfamily","TKL protein kinase STKR Type 2 subfamily","TKL protein kinase LZK subfamily","AGC protein kinase MSK subfamily","CMGC protein kinase PFTAIRE","AGC protein kinase GRK subfamily","CAMK p
rotein kinase MELK subfamily","AGC protein kinase PKC eta subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases",Atypical,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: C
ontaining PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","Lipid modifying kinases","TK: Tyrosine kinase","Other protein kinases","R
IO family","CLK family","Death-associated kinase (DAPK) family","TKL: Tyrosine kinase-like","Protein kinase A (PKA) family","STE20 family","Mitogen-activated protein kinases (MAP kinases)","Dual-speci
ficity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Casein kinase 1 (CK1) family","CAMK2 family","CAMK1 family","CAMK-like (CAMKL) family","STE7 family","Protein kinase C (PKC) family
","Cyclin-dependent kinase (CDK) family","DMPK family","Protein kinase N (PKN) family","NDR family","YANK family","MAST family","RSK family","DCAMKL family","STE11 family","Type I PIP kinases (1-phosp
hatidylinositol-4-phosphate 5-kinase family)","Protein kinase G (PKG) family","Phosphorylase kinase (PHK) family","MAPK-Activated Protein Kinase (MAPKAPK) family","ABC1 family","Protein kinase D (PKD)
 family","RCK family","PDK1 family","SRPK family","CASK family","G protein-coupled receptor kinases (GRKs)","Testis specific kinase (TSSK) family","Myosin Light Chain Kinase (MLCK) family","CAMK-uniqu
e family","1-phosphatidylinositol 4-kinase family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)"
,"Aurora kinase (Aur) family","RIO3 subfamily","Receptor serine/threonine kinase (RSTK) family","Polo-like kinase (PLK) family","PAKB subfamily","KHS subfamily","p38 subfamily","Mixed Lineage Kinase (
MLK) family","PAKA subfamily","LIM domain kinase (LISK) family","HIPK subfamily","PEK family","MSN subfamily","MARK subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","ERK subfam
ily","JNK subfamily","Delta subfamily","Leucine-rich repeat kinase (LRRK) family","QIK subfamily","TAIRE subfamily","AMPK subfamily","GEK subfamily","YSK subfamily","TAO subfamily","SLK subfamily","Un
c-51-like kinase (ULK) family","Interleukin-1 receptor-associated kinase (IRAK) family","Casein kinase 2 (CK2) family","BRSK subfamily","CDK1 subfamily","RSK subfamily","p70 subfamily","CDK5 subfamily
","CDK7 subfamily","MKN subfamily","ABC1-B subfamily","Erk7 subfamily","FRAY subfamily","NAK family","CDK4 subfamily","CHK1 subfamily","MST subfamily","CAMKK family","NuaK subfamily","SNRK subfamily",
"NIM1 subfamily","Rho kinase","Dyrk1 subfamily","Numb-associated kinase (NAK) family","NinaC subfamily","IRE family","Other-unique family","NKF1 family","PRP4 subfamily","MSK subfamily","Receptor inte
racting protein kinase (RIPK) family","WEE family","STE20 subfamily","Opsin/rhodopsin kinases","NKF4 family","GRK4 subfamily","MELK subfamily","Eta subfamily","IKK family","TTK family","HUNK subfamily
","Type XII RTKs: TIE family of angiopoietin receptors","Tec family","Type I receptor serine/threonine kinases","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type I RTKs: ErbB (epidermal gro
wth factor) receptor family","Type XIII RTKs: Ephrin receptor family","Src family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","MLK subfamily","Type IV RTKs: VEGF (vascular endothel
ial growth factor) receptor family","LIMK subfamily","Csk family","GCN2 subfamily","TAK1 subfamily","Fak family","Syk family","Type II RTKs: Insulin receptor family","Fer family","HH498 subfamily","Ab
l family","Ack family","Janus kinase (JakA) family","Type XIV RTKs: RET","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family",
"Type VII RTKs: Neurotrophin receptor/Trk family","Type XVI RTKs: DDR (collagen receptor) family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Meta subfamily","Type XVII RTKs: ROS re
ceptors","Type II receptor serine/threonine kinases","LZK subfamily","Type IX RTKs: MuSK"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Gene expression (Transcription)","Metabolism of RNA","Cell Cycle",Disease,"Developmental Biology","Programmed Cell Death",Hemostasis,"Cellular responses to exte
rnal stimuli","Neuronal System","Metabolism of proteins","Muscle contraction",Autophagy,Metabolism,"Extracellular matrix organization","Circadian Clock","Organelle biogenesis and maintenance","DNA Rep
air","Vesicle-mediated transport","MAPK family signaling cascades","Innate Immune System","RNA Polymerase II Transcription","rRNA processing","Signaling by TGFB family members",Mitotic,"Infectious dis
ease","Signaling by GPCR","Nervous system development",Apoptosis,"Signaling by Receptor Tyrosine Kinases","Cell surface interactions at the vascular wall","Intracellular signaling by second messengers
","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Immune system","Cellular responses to stress","Transmission across Chemical Synapses","Disor
ders of Developmental Biology","Signaling by Non-Receptor Tyrosine Kinases","Adaptive Immune System","Signaling by Rho GTPases",Translation,"Signaling by Hedgehog","Cardiac conduction","MTOR signallin
g",Macroautophagy,"Signaling by Hippo","Metabolism of lipids","Platelet homeostasis","Non-integrin membrane-ECM interactions","Metabolism of carbohydrates","Cilium Assembly","Unfolded Protein Response
 (UPR)","DNA Double-Strand Break Repair","Signaling by NODAL","Cell Cycle Checkpoints","Membrane Trafficking","ECM proteoglycans","MAPK1/MAPK3 signaling","Fc epsilon receptor (FCERI) signaling","Gener
ic Transcription Pathway","rRNA processing in the nucleus and cytosol","Signaling by BMP","Mitotic G2-G2/M phases","Leishmania infection","GPCR downstream signalling","Axon guidance","Caspase activati
on via extrinsic apoptotic signalling pathway","Signaling by NTRKs","HIV Infection","DAG and IP3 signaling","Signaling by VEGF","Oncogenic MAPK signaling","Signaling by Interleukins","Response of EIF2
AK4 (GCN2) to amino acid deficiency","Cellular Senescence","Neurotransmitter receptors and postsynaptic signal transmission","Disorders of Nervous System Development","Toll-like Receptor Cascades","M 
Phase","Signaling by PTK6","TCR signaling","PIP3 activates AKT signaling","Signaling by KIT in disease","RHO GTPase Effectors","Neutrophil degranulation","Mitotic G1 phase and G1/S transition","tRNA A
minoacylation","Signaling by Insulin receptor","Hedgehog 'on' state","Interferon Signaling","Regulation of mitotic cell cycle","Ion homeostasis","Signaling by MST1","mTORC1-mediated signalling","Selec
tive autophagy","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Signaling by TGF-beta Receptor Complex in Cancer","Phospholipid metabolism","Nitric oxide stimulates guanylate cycl
ase","Signaling by PDGFR in disease","Glycogen metabolism","Signaling by FGFR","Anchoring of the basal body to the plasma membrane","Apoptotic execution phase","Signaling by FGFR in disease","Sphingol
ipid metabolism","IRE1alpha activates chaperones","Homology Directed Repair","Regulation of signaling by NODAL","G2/M Checkpoints","Signaling by ERBB2","Fcgamma receptor (FCGR) dependent phagocytosis"
,"trans-Golgi Network Vesicle Budding","Signaling by SCF-KIT","Clathrin-mediated endocytosis","RAF/MAP kinase cascade","FCERI mediated Ca+2 mobilization","Transcriptional Regulation by TP53","Major pa
thway of rRNA processing in the nucleolus and cytosol","G2/M Transition","Leishmania parasite growth and survival","Transcriptional Regulation by VENTX","G alpha (q) signalling events","EPH-Ephrin sig
naling","Signaling by ROBO receptors","Parasite infection","Caspase activation via Dependence Receptors in the absence of ligand","Transcriptional regulation by RUNX1","Signaling by NTRK1 (TRKA)","Hos
t Interactions of HIV factors","CaM pathway","VEGFA-VEGFR2 Pathway","Semaphorin interactions","Signaling by RAS mutants",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Oxidative Stress Induced Se
nescence","Activation of NMDA receptors and postsynaptic events","Pervasive developmental disorders","VEGF ligand-receptor interactions","Toll Like Receptor 5 (TLR5) Cascade","Mitotic Prophase","Toll 
Like Receptor 4 (TLR4) Cascade","PTK6 promotes HIF1A stabilization","Generation of second messenger molecules","Negative regulation of the PI3K/AKT network","Drug resistance of KIT mutants","RHO GTPas
es activate PKNs","Mitotic Metaphase and Anaphase","Interleukin-2 family signaling","G1 Phase","Cytosolic tRNA aminoacylation","Insulin receptor signalling cascade","Antiviral mechanism by IFN-stimula
ted genes","PTK6 Down-Regulation","APC/C-mediated degradation of cell cycle proteins","RET signaling",Mitophagy,"IGF1R signaling cascade","Loss of Function of SMAD2/3 in Cancer","PI Metabolism","HIV L
ife Cycle","cGMP effects","Interferon alpha/beta signaling","Drug resistance of PDGFR mutants","Glycogen breakdown (glycogenolysis)","G alpha (i) signalling events","Signaling by FGFR4","Apoptotic cle
avage of cellular proteins","Signaling by FGFR1 in disease","Signaling by FGFR3 in disease","Sphingolipid de novo biosynthesis","Toll Like Receptor 2 (TLR2) Cascade","PTEN Regulation","HDR through Hom
ologous Recombination (HRR) or Single Strand Annealing (SSA)","L1CAM interactions","G2/M DNA damage checkpoint","Signaling by FGFR2 in disease","Downregulation of ERBB2 signaling","RHO GTPases activat
e PAKs","Role of phospholipids in phagocytosis","Golgi Associated Vesicle Biogenesis","Interleukin-1 family signaling","G0 and Early G1","Cargo recognition for clathrin-mediated endocytosis","Regulati
on of TP53 Activity","Centrosome maturation","Anti-inflammatory response favouring Leishmania parasite infection","Gastrin-CREB signalling pathway via PKC and MAPK","EPHA-mediated growth cone collapse
","Activation of RAC1","Leishmania phagocytosis","RUNX1 regulates transcription of genes involved in BCR signaling","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis"
,"Calmodulin induced events","VEGFR2 mediated cell proliferation","Sema4D in semaphorin signaling","Signaling downstream of RAS mutants","EPHB-mediated forward signaling","Post NMDA receptor activatio
n events","Loss of function of MECP2 in Rett syndrome","VEGF binds to VEGFR leading to receptor dimerization","MyD88 cascade initiated on plasma membrane","Nuclear Envelope Breakdown","MyD88-independe
nt TLR4 cascade",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Dasatinib-resistant KIT mutants","CRMPs in Sema3A signaling","Mitotic Anaphase","Interleukin-2 signaling","Role of ABL in ROBO-SLIT s
ignaling","Cyclin D associated events in G1","IRS-mediated signalling","ISG15 antiviral mechanism","Signalling to ERK5","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","
Receptor Mediated Mitophagy","IRS-related events triggered by IGF1R","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Synthesis of PIPs at the plasma membrane","Late Phase of HIV Life Cycle","Regula
tion of IFNA signaling","Imatinib-resistant PDGFR mutants","Visual phototransduction","Downstream signaling of activated FGFR4","RAS processing","FGFR1 mutant receptor activation","Signaling by FGFR3 
point mutants in cancer","Toll Like Receptor TLR6:TLR2 Cascade","Regulation of PTEN stability and activity","HDR through Homologous Recombination (HRR)","Recycling pathway of L1","Ephrin signaling","A
ssembly and cell surface presentation of NMDA receptors","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Interleukin-15 signaling","FGFR2 mutant receptor activation","Activated PKN1 
stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Interleukin-1 signaling","Synthesis of PIPs at the Golgi membrane","Activation of TRKA receptors","Regulation of TP53
 Activity through Phosphorylation","Loss of proteins required for interphase microtubule organization from the centrosome","ADORA2B mediated anti-inflammatory cytokines production","EGFR Transactivati
on by Gastrin","FCGR3A-mediated IL10 synthesis","FCGR3A-mediated phagocytosis","Signalling to RAS","Nef and signal transduction","PKA-mediated phosphorylation of CREB","Sema4D induced cell migration a
nd growth-cone collapse","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Loss of phosphorylation of MECP2 at T308","MAP kinase activation","Activation of NIMA Kinas
es NEK9",NEK6,NEK7,"TRIF(TICAM1)-mediated TLR4 signaling","Separation of Sister Chromatids","PI3K Cascade","APC/C:Cdc20 mediated degradation of mitotic proteins","Prolonged ERK activation events","Tra
nscription of the HIV genome","Regulation of TP53 Activity through Acetylation","Sema4D mediated inhibition of cell attachment and migration","Nef-mediates down modulation of cell surface receptors by
 recruiting them to clathrin adapters","The phototransduction cascade","CD163 mediating an anti-inflammatory response","FRS-mediated FGFR4 signaling","Signaling by activated point mutants of FGFR1","F
GFR3 mutant receptor activation","Regulation of TP53 Expression and Degradation","Activation of AMPK downstream of NMDARs","Activation of RAC1 downstream of NMDARs","MyD88:MAL(TIRAP) cascade initiated
 on plasma membrane","Long-term potentiation","Homologous DNA Pairing and Strand Exchange","Activated point mutants of FGFR2","NGF-independant TRKA activation","Loss of Nlp from mitotic centrosomes","
p38MAPK events","PKA activation","Ras activation upon Ca2+ influx through NMDA receptor","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","MAPK targets/ Nuclear e
vents mediated by MAP kinases","TRAF6-mediated induction of TAK1 complex within TLR4 complex","activated TAK1 mediates p38 MAPK activation","APC:Cdc20 mediated degradation of cell cycle proteins prior
 to satisfation of the cell cycle checkpoint","RSK activation","ARMS-mediated activation","HIV Transcription Elongation","PI5P Regulates TP53 Acetylation","Nef Mediated CD4 Down-regulation",Inactivati
on,"recovery and regulation of the phototransduction cascade","Frs2-mediated activation","Signaling by activated point mutants of FGFR3","Regulation of TP53 Degradation","Presynaptic phase of homologo
us DNA pairing and strand exchange","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","ERK/MAPK targets","Activation of the AP-1 family of transcription factors","Cdc20:Phospho-APC/C mediated deg
radation of Cyclin A","CREB phosphorylation","APC-Cdc20 mediated degradation of Nek2A","Tat-mediated elongation of the HIV-1 transcript","ERKs are inactivated","Formation of HIV-1 elongation complex c
ontaining HIV-1 Tat"}

> <broad_targets>
{ALK,INSR}

> <broad_moa>
{"ALK tyrosine kinase receptor inhibitor"}

> <synonyms>
{761439-42-3,761439423,NVP-TAE684,NVPTAE684,TAE684,"NVP-TAE 684","NVPTAE 684",TAE-684,"TAE684 (NVP-TAE684)","TAE684 (NVPTAE684)","TAE 684",UNII-EH1713MN4K,UNIIEH1713MN4K,CHEMBL509032,EH1713MN4K,C30H40
ClN7O3S,NVT-TAE-684,NVTTAE684,GUI,Kinome_1205,Kinome1205,Kinome-1205,"Kinome 1205",PubChem16769,cc-17,cc17,MLS006010970,"NVP TAE 684",NVP-TAE684/,NVPTAE684/,SCHEMBL282775,GTPL,T2251,S1108,"NVP TAE684"
}

> <pdid>
PD003442

> <targets>
{ALK}

> <classes>
{}

> <pubchem_cids>
{16038120}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    7.5955    2.7333    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    4.2568    0.5878    0.0000 C   0  0
    5.7171    0.9385    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    4.8082   -4.6653    0.0000 C   0  0
    6.2996   -4.8254    0.0000 C   0  0
    3.9242   -5.8772    0.0000 C   0  0
    5.4155   -6.0369    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12  8  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 16  1  0
 21 22  2  0
 22 13  1  0
 10 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28457

> <plate>
Kinase v5-2

> <well>
K07

> <supplier_cmpd_name>
SB 525334

> <ctcr_id>
5800

> <supplier_cmpd_id>
S1476

> <smiles>
Cc1cccc(n1)c2[nH]c(nc2c3ccc4nccnc4c3)C(C)(C)C

> <pd_targets>
{MTOR,SMAD3,TGFB1,TGFBR1}

> <pathway_gtopdb>
{Enzyme,"Secreted protein",Kinase,"Protein Kinase","Atypical protein kinase group","TKL protein kinase group","Atypical protein kinase PIKK family","TKL protein kinase STKR family","Atypical protein k
inase FRAP subfamily","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors",Atypical,"Receptor kinases","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","TKL: Tyrosine kinase-like","FRAP subfamily"
,"Receptor serine/threonine kinase (RSTK) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,"RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","Signali
ng by TGF-beta Receptor Complex in Cancer","Transcriptional Regulation by TP53","Loss of Function of SMAD2/3 in Cancer","Regulation of TP53 Activity","SMAD2/3 Phosphorylation Motif Mutants in Cancer",
"Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{356559-20-1,356559201,"SB 525334",SB-525334,SB525334,6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline,6(2(tertButyl)5(6methylpyridin2yl)1Himidazol4yl)quinoxaline,6-(2-TERT-BUTY
L-5-(6-METHYL-PYRIDIN-2-YL)-1H-IMIDAZOL-4-YL)-QUINOXALINE,6(2TERTBUTYL5(6METHYLPYRIDIN2YL)1HIMIDAZOL4YL)QUINOXALINE,CHEMBL401570,MFCD11045307,6-(2-tert-butyl-5-(6-methylpyr,6(2tertbutyl5(6methylpyr,T1
763,S1476}

> <pdid>
PD003675

> <targets>
{ALK,TGF-beta/Smad}

> <classes>
{TGF-beta/Smad}

> <pubchem_cids>
{9967941}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
   -3.9323   -9.7235    0.0000 C   0  0
   -2.6374  -10.4807    0.0000 O   0  0
   -1.3331   -9.7383    0.0000 C   0  0
   -1.3269   -8.2383    0.0000 C   0  0
   -0.0248   -7.4935    0.0000 C   0  0
   -0.0156   -5.9927    0.0000 N   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    5.1932   -3.0130    0.0000 F   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1781   -0.0305    0.0000 C   0  0
   -3.8619    2.2496    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    1.2935   -3.7495    0.0000 N   0  0
    1.2712   -8.2490    0.0000 C   0  0
    1.2650   -9.7490    0.0000 C   0  0
    2.5632  -10.5020    0.0000 O   0  0
    3.8643   -9.7555    0.0000 C   0  0
   -0.0371  -10.4936    0.0000 C   0  0
   -0.0464  -11.9944    0.0000 O   0  0
   -1.3495  -12.7372    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  1  0
 19 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 17  1  0
 25 26  2  0
 26 14  1  0
 12 27  2  0
 27  7  1  0
  5 28  2  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 29 32  2  0
 32  3  1  0
 32 33  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28458

> <plate>
Kinase v5-2

> <well>
K09

> <supplier_cmpd_name>
R406

> <ctcr_id>
4240

> <supplier_cmpd_id>
S2194

> <smiles>
COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC

> <pd_targets>
{MARK3,PAK1,PDPK1,MAPK8,RAF1,ROS1,MAP2K4,TEC,TTK,PIP4K2B,CAMK1,ACVR1B,EPHA2,EPHA7,DYRK4,SYK,ROCK2,ABL1,EGFR,MUSK,PRKCD,MAPK12,PRKAA1,DDR2,JAK3,KIT,HIPK2,MAP2K2,MET,MYLK4,MAP4K1,CDK2,CSNK2A1,GSK3B,TLK1
,PIP5K1C,INSRR,TNIK,TAOK3,MKNK2,RET,PKNB,MAPK9,NEK11,AURKB,AAK1,FLT3,TYK2,JAK1,SLK,DAPK2,CDKL2,MAP4K3,EPHB1,EPHB6,MAPK14,PIK3CD,SRC,TIE1,DCLK3,STK35,RPS6KA5,DAPK1,PLK1,ROCK1,PTK6,MAP3K2,LIMK1,MAP3K11,
NEK2,STK16,MAPK13,RPS6KA1,DYRK2,PLK3,ALK,LRRK2,WEE2,PRKCG,MAPK1,MAPK3,MAP3K3,PRKACA,MAP2K1,PTK2B,EPHA5,ZAP70,AURKC,NTRK3,TNK2,PIP5K1A,DDR1,COQ8A,CAMK1G,COQ8B,MAP3K19,MARK1,LYN,MAP3K10,GRK1,NEK4,RPS6KB
1,TGFBR2,STK17B,BRAF,EIF2AK2,ULK1,ANKK1,SBK3,BTK,STK32A,ULK3,CAMK1D,RIOK1,NEK9,IGF1R,PIM3,PAK4,ERBB4,ACVR1,BMX,KDR,NEK1,TNNI3K,GSK3A,RIPK4,FGFR1,TSSK1B,MAP3K7,HIPK1,FYN,EPHA6,STK38,SRPK3,NEK6,IRAK4,PR
KG2,PRKAA2,NEK7,MAP3K9,PI4KB,MAP2K3,MAP2K6,WEE1,PTK2,GRK4,NEK5,CLK1,TEK,SBK1,CSNK2A2,IRAK1,STK33,RIOK2,TAOK1,MARK4,TLK2,NUAK2,FGFR3,EIF2AK4,CHEK1,CHUK,DAPK3,FLT1,FRK,PLK4,LATS2,SIK2,EPHA8,FGFR2,PIP4K2
C,MAPK15,CIT,EPHB2,TESK1,RIPK2,OXSR1,FER,YES1,DYRK1A,STK17A,JAK2,ABL2,CSF1R,LCK,ITK,PRKD3,MAP3K4,PDGFRA,LIMK2,HIPK3,NTRK2,NEK3,SRPK1,AURKA,EPHB4,CAMK2A,CAMK2G,LTK,CDK1,STK11,PAK5,PAK3,MAPK10,SIK1,HIPK
4,CAMK2D,HCK,CDK7,ERN1,BMP2K,PAK6,MKNK1,BLK,STK36,CLK4,EPHA1,TBK1,IKBKE,TAOK2,STK3,RIOK3,CLK3,EPHA3,PAK2,PDGFRB,STK10,PKN2,MYLK,MERTK,RPS6KA4,IKBKB,NUAK1,MARK2,GRK7,FLT4,INSR,MST1R,ULK2,RPS6KA3,GAK,PR
KACB,CLK2,CDKL1,NIM1K,MAP2K5,CDK17,AXL,FES,CDK5,PLK2,ERBB2,NTRK1,BMPR1B,IRAK3,TNK1,CSK,MAP4K2,EPHA4,PKN1,FGFR4,TYRO3,STK25,TXK,CDC7,PHKG2,PRKD2,FGR,SRMS,TGFBR1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,Transferase,"Protein Kinase","CAMK protein kinase group","STE protein kinase group","AGC protein kinase group","CMGC protein kinase group","TKL protein kinase gro
up","TK protein kinase group","Other protein kinase group","Atypical protein kinase group","CAMK protein kinase CAMK1 family","STE protein kinase STE20 family","AGC protein kinase PDK1 subfamily","CMG
C protein kinase MAPK family","TKL protein kinase RAF family","Tyrosine protein kinase Sev family","STE protein kinase STE7 family","Tyrosine protein kinase Tec family","Other protein kinase TTK famil
y","TKL protein kinase STKR family","Tyrosine protein kinase Eph family","CMGC protein kinase DYRK family","Tyrosine protein kinase Syk family","AGC protein kinase DMPK family","Tyrosine protein kinas
e Abl family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Musk family","AGC protein kinase PKC family","Tyrosine protein kinase DDR family","Tyrosine protein kinase JakA family","Ty
rosine protein kinase PDGFR family","Tyrosine protein kinase Met family","CAMK protein kinase MLCK family","CMGC protein kinase CDK family","Other protein kinase CK2 family","CMGC protein kinase GSK f
amily","Other protein kinase TLK family","Tyrosine protein kinase InsR family","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Ret family","Other protein kinase NEK family","Other protei
n kinase AUR family","Other protein kinase NAK family","CAMK protein kinase DAPK family","CMGC protein kinase CDKL family","Tyrosine protein kinase Src family","Tyrosine protein kinase Tie family","CA
MK protein kinase DCAMK1 family","Other protein kinase NKF4 family","AGC protein kinase RSK family","Other protein kinase PLK family","STE protein kinase STE11 family","TKL protein kinase LISK family"
,"TKL protein kinase MLK family","TKL protein kinase LRRK family","Other protein kinase WEE family","AGC protein kinase PKA family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Trk fa
mily","Tyrosine protein kinase Ack family","Atypical protein kinase ABC1 family","AGC protein kinase GRK family","Other protein kinase PEK family","Other protein kinase ULK family","TKL protein kinase
 RIPK family","Other protein kinase NKF1 family","AGC protein kinase YANK family","Atypical protein kinase RIO family","CAMK protein kinase PIM family","Tyrosine protein kinase VEGFR family","Tyrosine
 protein kinase FGFR family","CAMK protein kinase TSSK family","AGC protein kinase NDR family","CMGC protein kinase SRPK family","TKL protein kinase IRAK family","AGC protein kinase PKG family","CMGC 
protein kinase CLK family","CAMK protein kinase unique family","Other protein kinase IKK family","Tyrosine protein kinase Fer family","CAMK protein kinase PKD family","CAMK protein kinase CAMK2 family
","Tyrosine protein kinase Alk family","AGC protein kinase PKN family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Csk family","Other protein kinase CDC7 family","CAMK protein kinase
 PHk family","CAMK protein kinase MARK subfamily","STE protein kinase PAKA subfamily","CMGC protein kinase JNK subfamily","TKL protein kinase STKR Type 1 subfamily","AGC protein kinase ROCK subfamily"
,"AGC protein kinase PKC delta subfamily","CMGC protein kinase p38 subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase KHS subfamily","CMGC protein
 kinase CDC2 subfamily","STE protein kinase MSN subfamily","STE protein kinase TAO subfamily","CAMK protein kinase MNK subfamily","Other protein kinase Nek11","STE protein kinase SLK subfamily","AGC p
rotein kinase MSK subfamily","STE protein kinase MEKK2","TKL protein kinase LIMK subfamily","TKL protein kinase MLK subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase Dyrk2 subfamily",
"Other protein kinase WEE1","AGC protein kinase PKC alpha subfamily","CMGC protein kinase ERK1","Atypical protein kinase ABC1-A subfamily","AGC protein kinase GRK subfamily","AGC protein kinase p70 su
bfamily","TKL protein kinase STKR Type 2 subfamily","Other protein kinase PKR","Atypical protein kinase RIO1 subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR1","TKL protein kina
se HH498 subfamily","TKL protein kinase TAK1 subfamily","Tyrosine protein kinase SrcA","Atypical protein kinase RIO2 subfamily","CAMK protein kinase NuaK subfamily","Other protein kinase GCN2 subfamil
y","CAMK protein kinase CHK1 subfamily","CAMK protein kinase QIK subfamily","AGC protein kinase CRIK subfamily","TKL protein kinase TESK subfamily","STE protein kinase FRAY subfamily","CMGC protein ki
nase Dyrk1 subfamily","Other protein kinase Nek1","CAMK protein kinase LKB subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase MST subfamily","Atypical protein kinase RIO3 subfamily","
CAMK protein kinase NIM1 subfamily","CMGC protein kinase PCTAIRE","CMGC protein kinase CDK5 subfamily","Other protein kinase PLK2","STE protein kinase YSK subfamily","Tyrosine protein kinase Srm"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containi
ng PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Lipid modifying kinases",Atypical,"CAMK-like (CAMKL) family","STE20 family","PDK1 family","Mitogen-activa
ted protein kinases (MAP kinases)","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","STE7 family","Other protein kinases","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","C
AMK1 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","DMPK family","Protein kinase C (PKC) family","Myosin Light Chain Kinase (MLCK) family","Cyclin-dependent ki
nase (CDK) family","Glycogen synthase kinase (GSK) family","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","MAPK-Activated Protein Kinase (MAPKAPK) family","Death-associated 
kinase (DAPK) family","Cyclin-dependent kinase-like (CDKL) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","DCAMKL family","RSK family","STE11 family","Protein kinase A (PKA) family","
ABC1 family","G protein-coupled receptor kinases (GRKs)","YANK family","RIO family","PIM family","Testis specific kinase (TSSK) family","NDR family","SRPK family","Protein kinase G (PKG) family","1-ph
osphatidylinositol 4-kinase family","CLK family","CAMK-unique family","Protein kinase D (PKD) family","CAMK2 family","Protein kinase N (PKN) family","Phosphorylase kinase (PHK) family","MARK subfamily
","PAKA subfamily","JNK subfamily","RAF family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","TTK family","Receptor serine/threonine kinase (RSTK) family","Dyrk1 subfamil
y","Rho kinase","Delta subfamily","p38 subfamily","AMPK subfamily","HIPK subfamily","KHS subfamily","CDK1 subfamily","Casein kinase 2 (CK2) family","GSK subfamily","Tousled-like kinase (TLK) family","
MSN subfamily","TAO subfamily","MKN subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","Aurora kinase (Aur) family","NAK family","SLK subfamily","NKF4 family","MSK subfamily","Po
lo-like kinase (PLK) family","LIM domain kinase (LISK) family","Mixed Lineage Kinase (MLK) family","RSK subfamily","Dyrk2 subfamily","Leucine-rich repeat kinase (LRRK) family","WEE family","Alpha subf
amily","ABC1-B subfamily","STE20 subfamily","Opsin/rhodopsin kinases","p70 subfamily","PEK family","Unc-51-like kinase (ULK) family","Receptor interacting protein kinase (RIPK) family","NKF1 family","
RIO1 subfamily","PAKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","GRK4 subfamily","RIO2 subfamily","NuaK subfamily","CHK1 subfamily","IKK family","QIK subfamily","Erk7 subfami
ly","Other DMPK family kinases","FRAY subfamily","LKB subfamily","CDK7 subfamily","IRE family","Numb-associated kinase (NAK) family","MST subfamily","RIO3 subfamily","NIM1 subfamily","TAIRE subfamily"
,"CDK5 subfamily","YSK subfamily","CDC7 family","Type XVII RTKs: ROS receptors","Tec family","Type I receptor serine/threonine kinases","Type XIII RTKs: Ephrin receptor family","Syk family","Abl famil
y","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IX RTKs: MuSK","Type XVI RTKs: DDR (collagen receptor) family","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3
 receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type II RTKs: Insulin receptor family","Type XIV RTKs: RET","Src family","Type XII RTKs: TIE family of angiopoietin rec
eptors","LIMK subfamily","MLK subfamily","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Fak family","Type VII RTKs: Neurotrophin receptor/Trk family","Ack family","Type II receptor 
serine/threonine kinases","Other PEK family kinases","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","HH498 subfamily","Type V RTKs: FGF (fibroblast growth factor) receptor f
amily","TAK1 subfamily","GCN2 subfamily","TESK subfamily","Fer family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Csk family"}

> <pathway_reactome>
{Disease,"Developmental Biology","Gene expression (Transcription)","Immune System","Signal Transduction","Neuronal System","Extracellular matrix organization","Cellular responses to external stimuli",
"Cell Cycle","Vesicle-mediated transport","Programmed Cell Death",Metabolism,Autophagy,"Metabolism of RNA","Organelle biogenesis and maintenance","DNA Repair","Cell-Cell communication","Circadian Cloc
k","Metabolism of proteins",Hemostasis,"Diseases of signal transduction by growth factor receptors and second messengers","Nervous system development","RNA Polymerase II Transcription","Innate Immune 
System","MAPK family signaling cascades","Cytokine Signaling in Immune system","Transmission across Chemical Synapses","Signaling by NODAL","Infectious disease","Signaling by GPCR","ECM proteoglycans"
,"Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases","Non-integrin membrane-ECM interactions","Cellular responses to stress",Mitotic,"Membrane Trafficking",Apoptosi
s,"Signaling by Non-Receptor Tyrosine Kinases","Adaptive Immune System","Metabolism of lipids","MTOR signalling",Macroautophagy,"Signaling by Hedgehog","rRNA processing","Cell Cycle Checkpoints","Cili
um Assembly","DNA Double-Strand Break Repair","Signaling by Hippo","Signaling by Rho GTPases","Cell junction organization","Unfolded Protein Response (UPR)","Cell surface interactions at the vascular 
wall","Signaling by TGFB family members","Metabolism of carbohydrates","Oncogenic MAPK signaling","Axon guidance","Generic Transcription Pathway","Toll-like Receptor Cascades","MAPK1/MAPK3 signaling",
"Signaling by Interleukins","Neurotransmitter receptors and postsynaptic signal transmission","Regulation of signaling by NODAL","Leishmania infection","GPCR downstream signalling","DAG and IP3 signal
ing","Signaling by NTRKs","Signaling by KIT in disease","SARS-CoV Infections","Cellular Senescence","M Phase","Clathrin-mediated endocytosis","Signaling by Insulin receptor","Interferon Signaling","Ca
spase activation via extrinsic apoptotic signalling pathway","Mitotic G2-G2/M phases","Mitotic G1 phase and G1/S transition","Regulation of mitotic cell cycle","Signaling by PTK6","TCR signaling","Pho
spholipid metabolism","mTORC1-mediated signalling","Signaling by TGF-beta Receptor Complex in Cancer","Influenza Infection","Selective autophagy","Hedgehog 'on' state","rRNA processing in the nucleus 
and cytosol","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Signaling by VEGF","Signaling by FGFR in disease","HIV Infection","G2/M Checkpoints","Anchoring of the basal body to t
he plasma membrane","Response of EIF2AK4 (GCN2) to amino acid deficiency","Homology Directed Repair","PIP3 activates AKT signaling","RHO GTPase Effectors","Cell-extracellular matrix interactions","Sig
naling by SCF-KIT","Sphingolipid metabolism","Signaling by PDGFR in disease","IRE1alpha activates chaperones","Signaling by FGFR","Neutrophil degranulation","Signaling by MST1","trans-Golgi Network Ve
sicle Budding","Signaling by BMP","Fc epsilon receptor (FCERI) signaling","Glycogen metabolism","Signaling by RAS mutants","EPH-Ephrin signaling","Transcriptional Regulation by TP53","Toll Like Recept
or 5 (TLR5) Cascade","RAF/MAP kinase cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Activation of NMDA receptors and postsynaptic events","Leishmania parasite growth and survival","Semap
horin interactions","Parasite infection","G alpha (q) signalling events","CaM pathway","Signaling by NTRK1 (TRKA)","Interleukin-2 family signaling","Drug resistance of KIT mutants","SARS-CoV-1 Infecti
on","Oxidative Stress Induced Senescence","RET signaling","Mitotic Metaphase and Anaphase","Cargo recognition for clathrin-mediated endocytosis","Insulin receptor signalling cascade","Interferon alpha
/beta signaling","Antiviral mechanism by IFN-stimulated genes","Caspase activation via Dependence Receptors in the absence of ligand","G2/M Transition","G1 Phase","APC/C-mediated degradation of cell c
ycle proteins","PTK6 promotes HIF1A stabilization","Glutamate binding","activation of AMPA receptors and synaptic plasticity","Interleukin-1 family signaling","Generation of second messenger molecules
","Signaling by NTRK3 (TRKC)","PI Metabolism","G alpha (i) signalling events","Loss of Function of SMAD2/3 in Cancer","NS1 Mediated Effects on Host Pathways",Mitophagy,"Major pathway of rRNA processin
g in the nucleolus and cytosol","Mitotic Prophase","IGF1R signaling cascade","Signaling by ROBO receptors","VEGFA-VEGFR2 Pathway","Signaling by FGFR1 in disease","Toll Like Receptor 4 (TLR4) Cascade",
"Host Interactions of HIV factors","Toll Like Receptor 2 (TLR2) Cascade","G2/M DNA damage checkpoint","Signaling by FGFR3 in disease","HDR through Homologous Recombination (HRR) or Single Strand Annea
ling (SSA)","VEGF ligand-receptor interactions","PTEN Regulation","Signaling by FGFR2 in disease","RHO GTPases activate CIT","Regulation of cytoskeletal remodeling and cell spreading by IPP complex co
mponents","G0 and Early G1","Transcriptional Regulation by VENTX","Sphingolipid de novo biosynthesis","Drug resistance of PDGFR mutants","HIV Life Cycle","Signaling by FGFR4","Transcriptional regulati
on by RUNX1","Negative regulation of the PI3K/AKT network","RHO GTPases activate PKNs","RHO GTPases activate PAKs","L1CAM interactions","Golgi Associated Vesicle Biogenesis","FCERI mediated Ca+2 mobil
ization","G1/S Transition","Glycogen breakdown (glycogenolysis)","PTK6 Down-Regulation","Signaling downstream of RAS mutants","EPHB-mediated forward signaling","Regulation of TP53 Activity","MyD88 cas
cade initiated on plasma membrane","Negative regulation of MAPK pathway","Post NMDA receptor activation events","EPHA-mediated growth cone collapse","Anti-inflammatory response favouring Leishmania pa
rasite infection","Sema4D in semaphorin signaling","Leishmania phagocytosis","Gastrin-CREB signalling pathway via PKC and MAPK","Calmodulin induced events","Signalling to ERKs","Interleukin-15 signali
ng","Dasatinib-resistant KIT mutants","SARS-CoV-1 Genome Replication and Transcription","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Mitotic Anaphase","IRS-mediated signalling"
,"Regulation of IFNA signaling","ISG15 antiviral mechanism","Interleukin receptor SHC signaling","Centrosome maturation","Cyclin D associated events in G1","Activation of APC/C and APC/C:Cdc20 mediate
d degradation of mitotic proteins","Trafficking of AMPA receptors","Interleukin-1 signaling","Interleukin-2 signaling","Activated NTRK3 signals through PI3K","Synthesis of PIPs at the plasma membrane"
,"Visual phototransduction","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Inhibition of PKR","Receptor Mediated Mitophagy","Nuclear Envelope Breakdown","IRS-related events triggered by IGF1R","Ac
tivation of RAC1","VEGFR2 mediated cell proliferation","FGFR1 mutant receptor activation","MyD88-independent TLR4 cascade","The role of Nef in HIV-1 replication and disease pathogenesis","Toll Like Re
ceptor TLR6:TLR2 Cascade","RAS processing","Synthesis of PIPs at the Golgi membrane","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Signaling by FGFR3 point mutants in cancer","HDR 
through Homologous Recombination (HRR)","VEGF binds to VEGFR leading to receptor dimerization","Regulation of PTEN stability and activity","FGFR2 mutant receptor activation","Role of ABL in ROBO-SLIT 
signaling","Imatinib-resistant PDGFR mutants","Activation of TRKA receptors","Ephrin signaling","Late Phase of HIV Life Cycle","Negative regulation of FGFR4 signaling","RUNX1 regulates transcription o
f genes involved in BCR signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Recycling pathway of L1","Signalling to ERK5","CRMPs in Sema3A signaling","Activated PKN1 stimulates transcription 
of AR (androgen receptor) regulated genes KLK2 and KLK3","Downstream signaling of activated FGFR4","Activation of the pre-replicative complex","Regulation of TP53 Expression and Degradation","MAP kina
se activation","Negative feedback regulation of MAPK pathway","Regulation of TP53 Activity through Acetylation","Activation of RAC1 downstream of NMDARs","FCGR3A-mediated IL10 synthesis","Sema4D induc
ed cell migration and growth-cone collapse","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Signalling to RAS","Regulation of TP53 Activity through Phosphorylation","Prolonged ERK ac
tivation events","Sema4D mediated inhibition of cell attachment and migration","Replication of the SARS-CoV-1 genome","Separation of Sister Chromatids","PI3K Cascade","Loss of proteins required for in
terphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic proteins","Trafficking of GluR2-containing AMPA receptors","The phototransduction cascade","Activati
on of NIMA Kinases NEK9",NEK6,NEK7,"Long-term potentiation","Signaling by activated point mutants of FGFR1","TRIF(TICAM1)-mediated TLR4 signaling","Nef and signal transduction","MyD88:MAL(TIRAP) casca
de initiated on plasma membrane","FGFR3 mutant receptor activation","Homologous DNA Pairing and Strand Exchange","Activated point mutants of FGFR2","Nef-mediates down modulation of cell surface recept
ors by recruiting them to clathrin adapters","NGF-independant TRKA activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Transcription of the HIV genome","Spr
y regulation of FGF signaling","PKA-mediated phosphorylation of CREB","CD163 mediating an anti-inflammatory response","FRS-mediated FGFR4 signaling","Regulation of TP53 Degradation","MAPK targets/ Nuc
lear events mediated by MAP kinases","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","PI5P Regulates TP53 Acetylation","p38MAPK events","Frs2-mediated activation
","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",Inactivation,"recovery and regulation of the phototra
nsduction cascade","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","activated TAK1 mediates p38 MAPK activation","Signaling by activated point mutants of FGFR
3","Presynaptic phase of homologous DNA pairing and strand exchange","IKK complex recruitment mediated by RIP1","Nef Mediated CD4 Down-regulation","Ras activation upon Ca2+ influx through NMDA recepto
r","HIV Transcription Elongation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","PKA activation","Activation of the AP-1 family of transcription factors","CREB phosphorylation","APC-Cdc20 med
iated degradation of Nek2A","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{RET,SYK}

> <broad_moa>
{"SYK inhibitor"}

> <synonyms>
{"Tamatinib free base",841290-80-0,841290800,"841290 80 0",R-406,R406,"R 406","R406 (free base)",tamatinib,"R406 free base","R406(free base)",UNII-RC3A285J2G,UNIIRC3A285J2G,"UNII RC3A285J2G",CHEMBL475
251,RC3A285J2G,"841290-80-0 (free base)","841290800 (free base)","841290 80 0 (free base)",C22H23FN6O5,BDBM50249542,3fqs,3piy,Kinome_1211,Kinome1211,Kinome-1211,"Kinome 1211",PubChem22483,QCR-9,QCR9,"
QCR 9",c,T2467,SY-R406,S1533}

> <pdid>
PD003501

> <targets>
{Syk}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{11213558}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
   -3.9323   -9.7235    0.0000 C   0  0
   -2.6374  -10.4807    0.0000 O   0  0
   -1.3331   -9.7383    0.0000 C   0  0
   -1.3269   -8.2383    0.0000 C   0  0
   -0.0248   -7.4935    0.0000 C   0  0
   -0.0156   -5.9927    0.0000 N   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    5.1932   -3.0130    0.0000 F   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1781   -0.0305    0.0000 C   0  0
   -3.8619    2.2496    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    1.2935   -3.7495    0.0000 N   0  0
    1.2712   -8.2490    0.0000 C   0  0
    1.2650   -9.7490    0.0000 C   0  0
    2.5632  -10.5020    0.0000 O   0  0
    3.8643   -9.7555    0.0000 C   0  0
   -0.0371  -10.4936    0.0000 C   0  0
   -0.0464  -11.9944    0.0000 O   0  0
   -1.3495  -12.7372    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  1  0
 19 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 17  1  0
 25 26  2  0
 26 14  1  0
 12 27  2  0
 27  7  1  0
  5 28  2  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 29 32  2  0
 32  3  1  0
 32 33  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28459

> <plate>
Kinase v5-2

> <well>
K11

> <supplier_cmpd_name>
R406(free base)

> <ctcr_id>
4240

> <supplier_cmpd_id>
S1533

> <smiles>
COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC

> <pd_targets>
{MARK3,PAK1,PDPK1,MAPK8,RAF1,ROS1,MAP2K4,TEC,TTK,PIP4K2B,CAMK1,ACVR1B,EPHA2,EPHA7,DYRK4,SYK,ROCK2,ABL1,EGFR,MUSK,PRKCD,MAPK12,PRKAA1,DDR2,JAK3,KIT,HIPK2,MAP2K2,MET,MYLK4,MAP4K1,CDK2,CSNK2A1,GSK3B,TLK1
,PIP5K1C,INSRR,TNIK,TAOK3,MKNK2,RET,PKNB,MAPK9,NEK11,AURKB,AAK1,FLT3,TYK2,JAK1,SLK,DAPK2,CDKL2,MAP4K3,EPHB1,EPHB6,MAPK14,PIK3CD,SRC,TIE1,DCLK3,STK35,RPS6KA5,DAPK1,PLK1,ROCK1,PTK6,MAP3K2,LIMK1,MAP3K11,
NEK2,STK16,MAPK13,RPS6KA1,DYRK2,PLK3,ALK,LRRK2,WEE2,PRKCG,MAPK1,MAPK3,MAP3K3,PRKACA,MAP2K1,PTK2B,EPHA5,ZAP70,AURKC,NTRK3,TNK2,PIP5K1A,DDR1,COQ8A,CAMK1G,COQ8B,MAP3K19,MARK1,LYN,MAP3K10,GRK1,NEK4,RPS6KB
1,TGFBR2,STK17B,BRAF,EIF2AK2,ULK1,ANKK1,SBK3,BTK,STK32A,ULK3,CAMK1D,RIOK1,NEK9,IGF1R,PIM3,PAK4,ERBB4,ACVR1,BMX,KDR,NEK1,TNNI3K,GSK3A,RIPK4,FGFR1,TSSK1B,MAP3K7,HIPK1,FYN,EPHA6,STK38,SRPK3,NEK6,IRAK4,PR
KG2,PRKAA2,NEK7,MAP3K9,PI4KB,MAP2K3,MAP2K6,WEE1,PTK2,GRK4,NEK5,CLK1,TEK,SBK1,CSNK2A2,IRAK1,STK33,RIOK2,TAOK1,MARK4,TLK2,NUAK2,FGFR3,EIF2AK4,CHEK1,CHUK,DAPK3,FLT1,FRK,PLK4,LATS2,SIK2,EPHA8,FGFR2,PIP4K2
C,MAPK15,CIT,EPHB2,TESK1,RIPK2,OXSR1,FER,YES1,DYRK1A,STK17A,JAK2,ABL2,CSF1R,LCK,ITK,PRKD3,MAP3K4,PDGFRA,LIMK2,HIPK3,NTRK2,NEK3,SRPK1,AURKA,EPHB4,CAMK2A,CAMK2G,LTK,CDK1,STK11,PAK5,PAK3,MAPK10,SIK1,HIPK
4,CAMK2D,HCK,CDK7,ERN1,BMP2K,PAK6,MKNK1,BLK,STK36,CLK4,EPHA1,TBK1,IKBKE,TAOK2,STK3,RIOK3,CLK3,EPHA3,PAK2,PDGFRB,STK10,PKN2,MYLK,MERTK,RPS6KA4,IKBKB,NUAK1,MARK2,GRK7,FLT4,INSR,MST1R,ULK2,RPS6KA3,GAK,PR
KACB,CLK2,CDKL1,NIM1K,MAP2K5,CDK17,AXL,FES,CDK5,PLK2,ERBB2,NTRK1,BMPR1B,IRAK3,TNK1,CSK,MAP4K2,EPHA4,PKN1,FGFR4,TYRO3,STK25,TXK,CDC7,PHKG2,PRKD2,FGR,SRMS,TGFBR1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,Transferase,"Protein Kinase","CAMK protein kinase group","STE protein kinase group","AGC protein kinase group","CMGC protein kinase group","TKL protein kinase gro
up","TK protein kinase group","Other protein kinase group","Atypical protein kinase group","CAMK protein kinase CAMK1 family","STE protein kinase STE20 family","AGC protein kinase PDK1 subfamily","CMG
C protein kinase MAPK family","TKL protein kinase RAF family","Tyrosine protein kinase Sev family","STE protein kinase STE7 family","Tyrosine protein kinase Tec family","Other protein kinase TTK famil
y","TKL protein kinase STKR family","Tyrosine protein kinase Eph family","CMGC protein kinase DYRK family","Tyrosine protein kinase Syk family","AGC protein kinase DMPK family","Tyrosine protein kinas
e Abl family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Musk family","AGC protein kinase PKC family","Tyrosine protein kinase DDR family","Tyrosine protein kinase JakA family","Ty
rosine protein kinase PDGFR family","Tyrosine protein kinase Met family","CAMK protein kinase MLCK family","CMGC protein kinase CDK family","Other protein kinase CK2 family","CMGC protein kinase GSK f
amily","Other protein kinase TLK family","Tyrosine protein kinase InsR family","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Ret family","Other protein kinase NEK family","Other protei
n kinase AUR family","Other protein kinase NAK family","CAMK protein kinase DAPK family","CMGC protein kinase CDKL family","Tyrosine protein kinase Src family","Tyrosine protein kinase Tie family","CA
MK protein kinase DCAMK1 family","Other protein kinase NKF4 family","AGC protein kinase RSK family","Other protein kinase PLK family","STE protein kinase STE11 family","TKL protein kinase LISK family"
,"TKL protein kinase MLK family","TKL protein kinase LRRK family","Other protein kinase WEE family","AGC protein kinase PKA family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Trk fa
mily","Tyrosine protein kinase Ack family","Atypical protein kinase ABC1 family","AGC protein kinase GRK family","Other protein kinase PEK family","Other protein kinase ULK family","TKL protein kinase
 RIPK family","Other protein kinase NKF1 family","AGC protein kinase YANK family","Atypical protein kinase RIO family","CAMK protein kinase PIM family","Tyrosine protein kinase VEGFR family","Tyrosine
 protein kinase FGFR family","CAMK protein kinase TSSK family","AGC protein kinase NDR family","CMGC protein kinase SRPK family","TKL protein kinase IRAK family","AGC protein kinase PKG family","CMGC 
protein kinase CLK family","CAMK protein kinase unique family","Other protein kinase IKK family","Tyrosine protein kinase Fer family","CAMK protein kinase PKD family","CAMK protein kinase CAMK2 family
","Tyrosine protein kinase Alk family","AGC protein kinase PKN family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Csk family","Other protein kinase CDC7 family","CAMK protein kinase
 PHk family","CAMK protein kinase MARK subfamily","STE protein kinase PAKA subfamily","CMGC protein kinase JNK subfamily","TKL protein kinase STKR Type 1 subfamily","AGC protein kinase ROCK subfamily"
,"AGC protein kinase PKC delta subfamily","CMGC protein kinase p38 subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase KHS subfamily","CMGC protein
 kinase CDC2 subfamily","STE protein kinase MSN subfamily","STE protein kinase TAO subfamily","CAMK protein kinase MNK subfamily","Other protein kinase Nek11","STE protein kinase SLK subfamily","AGC p
rotein kinase MSK subfamily","STE protein kinase MEKK2","TKL protein kinase LIMK subfamily","TKL protein kinase MLK subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase Dyrk2 subfamily",
"Other protein kinase WEE1","AGC protein kinase PKC alpha subfamily","CMGC protein kinase ERK1","Atypical protein kinase ABC1-A subfamily","AGC protein kinase GRK subfamily","AGC protein kinase p70 su
bfamily","TKL protein kinase STKR Type 2 subfamily","Other protein kinase PKR","Atypical protein kinase RIO1 subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR1","TKL protein kina
se HH498 subfamily","TKL protein kinase TAK1 subfamily","Tyrosine protein kinase SrcA","Atypical protein kinase RIO2 subfamily","CAMK protein kinase NuaK subfamily","Other protein kinase GCN2 subfamil
y","CAMK protein kinase CHK1 subfamily","CAMK protein kinase QIK subfamily","AGC protein kinase CRIK subfamily","TKL protein kinase TESK subfamily","STE protein kinase FRAY subfamily","CMGC protein ki
nase Dyrk1 subfamily","Other protein kinase Nek1","CAMK protein kinase LKB subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase MST subfamily","Atypical protein kinase RIO3 subfamily","
CAMK protein kinase NIM1 subfamily","CMGC protein kinase PCTAIRE","CMGC protein kinase CDK5 subfamily","Other protein kinase PLK2","STE protein kinase YSK subfamily","Tyrosine protein kinase Srm"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containi
ng PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Lipid modifying kinases",Atypical,"CAMK-like (CAMKL) family","STE20 family","PDK1 family","Mitogen-activa
ted protein kinases (MAP kinases)","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","STE7 family","Other protein kinases","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","C
AMK1 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","DMPK family","Protein kinase C (PKC) family","Myosin Light Chain Kinase (MLCK) family","Cyclin-dependent ki
nase (CDK) family","Glycogen synthase kinase (GSK) family","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","MAPK-Activated Protein Kinase (MAPKAPK) family","Death-associated 
kinase (DAPK) family","Cyclin-dependent kinase-like (CDKL) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","DCAMKL family","RSK family","STE11 family","Protein kinase A (PKA) family","
ABC1 family","G protein-coupled receptor kinases (GRKs)","YANK family","RIO family","PIM family","Testis specific kinase (TSSK) family","NDR family","SRPK family","Protein kinase G (PKG) family","1-ph
osphatidylinositol 4-kinase family","CLK family","CAMK-unique family","Protein kinase D (PKD) family","CAMK2 family","Protein kinase N (PKN) family","Phosphorylase kinase (PHK) family","MARK subfamily
","PAKA subfamily","JNK subfamily","RAF family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","TTK family","Receptor serine/threonine kinase (RSTK) family","Dyrk1 subfamil
y","Rho kinase","Delta subfamily","p38 subfamily","AMPK subfamily","HIPK subfamily","KHS subfamily","CDK1 subfamily","Casein kinase 2 (CK2) family","GSK subfamily","Tousled-like kinase (TLK) family","
MSN subfamily","TAO subfamily","MKN subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","Aurora kinase (Aur) family","NAK family","SLK subfamily","NKF4 family","MSK subfamily","Po
lo-like kinase (PLK) family","LIM domain kinase (LISK) family","Mixed Lineage Kinase (MLK) family","RSK subfamily","Dyrk2 subfamily","Leucine-rich repeat kinase (LRRK) family","WEE family","Alpha subf
amily","ABC1-B subfamily","STE20 subfamily","Opsin/rhodopsin kinases","p70 subfamily","PEK family","Unc-51-like kinase (ULK) family","Receptor interacting protein kinase (RIPK) family","NKF1 family","
RIO1 subfamily","PAKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","GRK4 subfamily","RIO2 subfamily","NuaK subfamily","CHK1 subfamily","IKK family","QIK subfamily","Erk7 subfami
ly","Other DMPK family kinases","FRAY subfamily","LKB subfamily","CDK7 subfamily","IRE family","Numb-associated kinase (NAK) family","MST subfamily","RIO3 subfamily","NIM1 subfamily","TAIRE subfamily"
,"CDK5 subfamily","YSK subfamily","CDC7 family","Type XVII RTKs: ROS receptors","Tec family","Type I receptor serine/threonine kinases","Type XIII RTKs: Ephrin receptor family","Syk family","Abl famil
y","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IX RTKs: MuSK","Type XVI RTKs: DDR (collagen receptor) family","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3
 receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type II RTKs: Insulin receptor family","Type XIV RTKs: RET","Src family","Type XII RTKs: TIE family of angiopoietin rec
eptors","LIMK subfamily","MLK subfamily","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Fak family","Type VII RTKs: Neurotrophin receptor/Trk family","Ack family","Type II receptor 
serine/threonine kinases","Other PEK family kinases","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","HH498 subfamily","Type V RTKs: FGF (fibroblast growth factor) receptor f
amily","TAK1 subfamily","GCN2 subfamily","TESK subfamily","Fer family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Csk family"}

> <pathway_reactome>
{Disease,"Developmental Biology","Gene expression (Transcription)","Immune System","Signal Transduction","Neuronal System","Extracellular matrix organization","Cellular responses to external stimuli",
"Cell Cycle","Vesicle-mediated transport","Programmed Cell Death",Metabolism,Autophagy,"Metabolism of RNA","Organelle biogenesis and maintenance","DNA Repair","Cell-Cell communication","Circadian Cloc
k","Metabolism of proteins",Hemostasis,"Diseases of signal transduction by growth factor receptors and second messengers","Nervous system development","RNA Polymerase II Transcription","Innate Immune 
System","MAPK family signaling cascades","Cytokine Signaling in Immune system","Transmission across Chemical Synapses","Signaling by NODAL","Infectious disease","Signaling by GPCR","ECM proteoglycans"
,"Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases","Non-integrin membrane-ECM interactions","Cellular responses to stress",Mitotic,"Membrane Trafficking",Apoptosi
s,"Signaling by Non-Receptor Tyrosine Kinases","Adaptive Immune System","Metabolism of lipids","MTOR signalling",Macroautophagy,"Signaling by Hedgehog","rRNA processing","Cell Cycle Checkpoints","Cili
um Assembly","DNA Double-Strand Break Repair","Signaling by Hippo","Signaling by Rho GTPases","Cell junction organization","Unfolded Protein Response (UPR)","Cell surface interactions at the vascular 
wall","Signaling by TGFB family members","Metabolism of carbohydrates","Oncogenic MAPK signaling","Axon guidance","Generic Transcription Pathway","Toll-like Receptor Cascades","MAPK1/MAPK3 signaling",
"Signaling by Interleukins","Neurotransmitter receptors and postsynaptic signal transmission","Regulation of signaling by NODAL","Leishmania infection","GPCR downstream signalling","DAG and IP3 signal
ing","Signaling by NTRKs","Signaling by KIT in disease","SARS-CoV Infections","Cellular Senescence","M Phase","Clathrin-mediated endocytosis","Signaling by Insulin receptor","Interferon Signaling","Ca
spase activation via extrinsic apoptotic signalling pathway","Mitotic G2-G2/M phases","Mitotic G1 phase and G1/S transition","Regulation of mitotic cell cycle","Signaling by PTK6","TCR signaling","Pho
spholipid metabolism","mTORC1-mediated signalling","Signaling by TGF-beta Receptor Complex in Cancer","Influenza Infection","Selective autophagy","Hedgehog 'on' state","rRNA processing in the nucleus 
and cytosol","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Signaling by VEGF","Signaling by FGFR in disease","HIV Infection","G2/M Checkpoints","Anchoring of the basal body to t
he plasma membrane","Response of EIF2AK4 (GCN2) to amino acid deficiency","Homology Directed Repair","PIP3 activates AKT signaling","RHO GTPase Effectors","Cell-extracellular matrix interactions","Sig
naling by SCF-KIT","Sphingolipid metabolism","Signaling by PDGFR in disease","IRE1alpha activates chaperones","Signaling by FGFR","Neutrophil degranulation","Signaling by MST1","trans-Golgi Network Ve
sicle Budding","Signaling by BMP","Fc epsilon receptor (FCERI) signaling","Glycogen metabolism","Signaling by RAS mutants","EPH-Ephrin signaling","Transcriptional Regulation by TP53","Toll Like Recept
or 5 (TLR5) Cascade","RAF/MAP kinase cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Activation of NMDA receptors and postsynaptic events","Leishmania parasite growth and survival","Semap
horin interactions","Parasite infection","G alpha (q) signalling events","CaM pathway","Signaling by NTRK1 (TRKA)","Interleukin-2 family signaling","Drug resistance of KIT mutants","SARS-CoV-1 Infecti
on","Oxidative Stress Induced Senescence","RET signaling","Mitotic Metaphase and Anaphase","Cargo recognition for clathrin-mediated endocytosis","Insulin receptor signalling cascade","Interferon alpha
/beta signaling","Antiviral mechanism by IFN-stimulated genes","Caspase activation via Dependence Receptors in the absence of ligand","G2/M Transition","G1 Phase","APC/C-mediated degradation of cell c
ycle proteins","PTK6 promotes HIF1A stabilization","Glutamate binding","activation of AMPA receptors and synaptic plasticity","Interleukin-1 family signaling","Generation of second messenger molecules
","Signaling by NTRK3 (TRKC)","PI Metabolism","G alpha (i) signalling events","Loss of Function of SMAD2/3 in Cancer","NS1 Mediated Effects on Host Pathways",Mitophagy,"Major pathway of rRNA processin
g in the nucleolus and cytosol","Mitotic Prophase","IGF1R signaling cascade","Signaling by ROBO receptors","VEGFA-VEGFR2 Pathway","Signaling by FGFR1 in disease","Toll Like Receptor 4 (TLR4) Cascade",
"Host Interactions of HIV factors","Toll Like Receptor 2 (TLR2) Cascade","G2/M DNA damage checkpoint","Signaling by FGFR3 in disease","HDR through Homologous Recombination (HRR) or Single Strand Annea
ling (SSA)","VEGF ligand-receptor interactions","PTEN Regulation","Signaling by FGFR2 in disease","RHO GTPases activate CIT","Regulation of cytoskeletal remodeling and cell spreading by IPP complex co
mponents","G0 and Early G1","Transcriptional Regulation by VENTX","Sphingolipid de novo biosynthesis","Drug resistance of PDGFR mutants","HIV Life Cycle","Signaling by FGFR4","Transcriptional regulati
on by RUNX1","Negative regulation of the PI3K/AKT network","RHO GTPases activate PKNs","RHO GTPases activate PAKs","L1CAM interactions","Golgi Associated Vesicle Biogenesis","FCERI mediated Ca+2 mobil
ization","G1/S Transition","Glycogen breakdown (glycogenolysis)","PTK6 Down-Regulation","Signaling downstream of RAS mutants","EPHB-mediated forward signaling","Regulation of TP53 Activity","MyD88 cas
cade initiated on plasma membrane","Negative regulation of MAPK pathway","Post NMDA receptor activation events","EPHA-mediated growth cone collapse","Anti-inflammatory response favouring Leishmania pa
rasite infection","Sema4D in semaphorin signaling","Leishmania phagocytosis","Gastrin-CREB signalling pathway via PKC and MAPK","Calmodulin induced events","Signalling to ERKs","Interleukin-15 signali
ng","Dasatinib-resistant KIT mutants","SARS-CoV-1 Genome Replication and Transcription","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Mitotic Anaphase","IRS-mediated signalling"
,"Regulation of IFNA signaling","ISG15 antiviral mechanism","Interleukin receptor SHC signaling","Centrosome maturation","Cyclin D associated events in G1","Activation of APC/C and APC/C:Cdc20 mediate
d degradation of mitotic proteins","Trafficking of AMPA receptors","Interleukin-1 signaling","Interleukin-2 signaling","Activated NTRK3 signals through PI3K","Synthesis of PIPs at the plasma membrane"
,"Visual phototransduction","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Inhibition of PKR","Receptor Mediated Mitophagy","Nuclear Envelope Breakdown","IRS-related events triggered by IGF1R","Ac
tivation of RAC1","VEGFR2 mediated cell proliferation","FGFR1 mutant receptor activation","MyD88-independent TLR4 cascade","The role of Nef in HIV-1 replication and disease pathogenesis","Toll Like Re
ceptor TLR6:TLR2 Cascade","RAS processing","Synthesis of PIPs at the Golgi membrane","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Signaling by FGFR3 point mutants in cancer","HDR 
through Homologous Recombination (HRR)","VEGF binds to VEGFR leading to receptor dimerization","Regulation of PTEN stability and activity","FGFR2 mutant receptor activation","Role of ABL in ROBO-SLIT 
signaling","Imatinib-resistant PDGFR mutants","Activation of TRKA receptors","Ephrin signaling","Late Phase of HIV Life Cycle","Negative regulation of FGFR4 signaling","RUNX1 regulates transcription o
f genes involved in BCR signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Recycling pathway of L1","Signalling to ERK5","CRMPs in Sema3A signaling","Activated PKN1 stimulates transcription 
of AR (androgen receptor) regulated genes KLK2 and KLK3","Downstream signaling of activated FGFR4","Activation of the pre-replicative complex","Regulation of TP53 Expression and Degradation","MAP kina
se activation","Negative feedback regulation of MAPK pathway","Regulation of TP53 Activity through Acetylation","Activation of RAC1 downstream of NMDARs","FCGR3A-mediated IL10 synthesis","Sema4D induc
ed cell migration and growth-cone collapse","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Signalling to RAS","Regulation of TP53 Activity through Phosphorylation","Prolonged ERK ac
tivation events","Sema4D mediated inhibition of cell attachment and migration","Replication of the SARS-CoV-1 genome","Separation of Sister Chromatids","PI3K Cascade","Loss of proteins required for in
terphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic proteins","Trafficking of GluR2-containing AMPA receptors","The phototransduction cascade","Activati
on of NIMA Kinases NEK9",NEK6,NEK7,"Long-term potentiation","Signaling by activated point mutants of FGFR1","TRIF(TICAM1)-mediated TLR4 signaling","Nef and signal transduction","MyD88:MAL(TIRAP) casca
de initiated on plasma membrane","FGFR3 mutant receptor activation","Homologous DNA Pairing and Strand Exchange","Activated point mutants of FGFR2","Nef-mediates down modulation of cell surface recept
ors by recruiting them to clathrin adapters","NGF-independant TRKA activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Transcription of the HIV genome","Spr
y regulation of FGF signaling","PKA-mediated phosphorylation of CREB","CD163 mediating an anti-inflammatory response","FRS-mediated FGFR4 signaling","Regulation of TP53 Degradation","MAPK targets/ Nuc
lear events mediated by MAP kinases","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","PI5P Regulates TP53 Acetylation","p38MAPK events","Frs2-mediated activation
","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",Inactivation,"recovery and regulation of the phototra
nsduction cascade","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","activated TAK1 mediates p38 MAPK activation","Signaling by activated point mutants of FGFR
3","Presynaptic phase of homologous DNA pairing and strand exchange","IKK complex recruitment mediated by RIP1","Nef Mediated CD4 Down-regulation","Ras activation upon Ca2+ influx through NMDA recepto
r","HIV Transcription Elongation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","PKA activation","Activation of the AP-1 family of transcription factors","CREB phosphorylation","APC-Cdc20 med
iated degradation of Nek2A","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{RET,SYK}

> <broad_moa>
{"SYK inhibitor"}

> <synonyms>
{"Tamatinib free base",841290-80-0,841290800,"841290 80 0",R-406,R406,"R 406","R406 (free base)",tamatinib,"R406 free base","R406(free base)",UNII-RC3A285J2G,UNIIRC3A285J2G,"UNII RC3A285J2G",CHEMBL475
251,RC3A285J2G,"841290-80-0 (free base)","841290800 (free base)","841290 80 0 (free base)",C22H23FN6O5,BDBM50249542,3fqs,3piy,Kinome_1211,Kinome1211,Kinome-1211,"Kinome 1211",PubChem22483,QCR-9,QCR9,"
QCR 9",c,T2467,SY-R406,S1533}

> <pdid>
PD003501

> <targets>
{Syk}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{11213558}

$$$$
UTKinase_V5
  SciTegic11012413002D

 46 49  0  0  1  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 O   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0866    3.7711    0.0000 N   0  0
   -9.0793    5.2719    0.0000 C   0  0
   -7.7764    6.0151    0.0000 O   0  0
  -10.3749    6.0295    0.0000 C   0  0
  -11.7592    6.1035    0.0000 C   0  0
  -11.0161    4.8004    0.0000 C   0  0
  -10.3671    7.5307    0.0000 C   0  0
   -9.0640    8.2735    0.0000 O   0  0
  -11.6625    8.2886    0.0000 N   0  0
  -11.6547    9.7894    0.0000 C   0  0
  -12.9483   10.5489    0.0000 C   0  0
  -12.9374   12.0489    0.0000 C   0  0
  -11.6330   12.7894    0.0000 C   0  0
  -11.6222   14.2894    0.0000 F   0  0
  -10.3394   12.0301    0.0000 C   0  0
  -10.3502   10.5301    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
   10.2990    7.1454    0.0000 O   0  0
   10.2990    5.6454    0.0000 C   0  0  1  0  0  0
    8.9990    4.8954    0.0000 C   0  0
    7.6990    5.6454    0.0000 C   0  0
    6.3997    4.8958    0.0000 O   0  0
    7.6990    7.1454    0.0000 O   0  0
   11.5990    4.8954    0.0000 C   0  0
   12.8983    5.6450    0.0000 O   0  0
   11.5990    3.3954    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 18  1  0
 18 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 27 29  1  0
 29 30  2  0
 30 24  1  0
 14 31  1  0
 31 32  2  0
 32 11  1  0
  9 33  2  0
 33  5  1  0
 33 34  1  0
 34 35  2  0
 35  3  1  0
 35 36  1  0
 36 37  1  0
 39 38  1  6
 39 40  1  0
 40 41  1  0
 41 42  2  0
 41 43  1  0
 39 44  1  0
 44 45  2  0
 44 46  1  0
M  END
> <name>
UTKinase_V5

> <id>
28460

> <plate>
Kinase v5-2

> <well>
K13

> <supplier_cmpd_name>
XL184

> <ctcr_id>
7593

> <supplier_cmpd_id>
S1119

> <smiles>
COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc5ccc(F)cc5)cc3)c2cc1OC.O[C@@H](CC(=O)O)C(=O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Cabozantinib Smalate","Cabozantinib S malate",1140909-48-3,1140909483,"1140909 48 3","Cabozantinib malate","cabozantinib (S)-malate","cabozantinib (S)malate","cabozantinib (S) malate","Cabozantinib 
(S-malate)","Cabozantinib (Smalate)","Cabozantinib (S malate)",Cabometyx,"Cabozantinib malate (XL184)",UNII-DR7ST46X58,UNIIDR7ST46X58,"UNII DR7ST46X58","Cabozantinib L-Malate Salt","Cabozantinib LMala
te Salt","Cabozantinib L Malate Salt","Cabozantinib s-malate (USAN)","Cabozantinib smalate (USAN)","Cabozantinib s malate (USAN)",DR7ST46X58,BMS907351,C,T1797,S4001,XL184}

> <pdid>

> <targets>
{Axl,VEGFR}

> <classes>
{}

> <pubchem_cids>
{25102846}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  1  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    1.2990    0.7500    0.0000 N   0  0
    2.5987    1.5004    0.0000 C   0  0
    3.9511    0.8815    0.0000 C   0  0
    4.9530    1.9978    0.0000 C   0  0
    4.2010    3.2957    0.0000 C   0  0
    2.7342    2.9815    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -1.3022    5.2508    0.0000 N   0  0
   -2.6030    5.9994    0.0000 C   0  0
   -3.8995    5.2449    0.0000 C   0  0
   -5.2011    5.9904    0.0000 C   0  0
   -5.2063    7.4904    0.0000 C   0  0
   -3.9099    8.2449    0.0000 C   0  0
   -2.6083    7.4994    0.0000 C   0  0
   -1.3127    8.2570    0.0000 O   0  0
   -1.3201    9.7570    0.0000 C   0  0
   -6.5071    8.2390    0.0000 C   0  0
   -7.8049    7.4868    0.0000 O   0  0
   -6.5102    9.7398    0.0000 N   0  0
   -7.8110   10.4884    0.0000 C   0  0
   -7.8163   11.9884    0.0000 C   0  0
   -9.1179   12.7339    0.0000 C   0  0
  -10.4143   11.9795    0.0000 N   0  0
  -11.7159   12.7250    0.0000 C   0  0
  -10.4092   10.4795    0.0000 C   0  0
   -9.1076    9.7340    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  5  1  0
  4 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 17 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 30 31  1  0
 31 25  1  0
 12 32  2  0
 32 33  1  0
 33 34  2  0
 34 10  1  0
 34 35  1  0
 35 36  1  0
 35 37  1  0
 37  3  1  0
 37 38  2  0
M  END
> <name>
UTKinase_V5

> <id>
28461

> <plate>
Kinase v5-2

> <well>
K15

> <supplier_cmpd_name>
BI 2536

> <ctcr_id>
1569

> <supplier_cmpd_id>
S1109

> <smiles>
CC[C@H]1N(C2CCCC2)c3nc(Nc4ccc(cc4OC)C(=O)NC5CCN(C)CC5)ncc3N(C)C1=O

> <pd_targets>
{PHKG2,TAOK1,CAMK2G,PRKD3,SLK,CHEK2,PRKCG,CSNK1G3,ALK,IRAK4,DAPK3,CSNK1D,EGFR,FER,CAMK2D,PRKD2,MINK1,RPS6KA3,MAP4K4,CLK2,PTK2,FES,PTK2B,CAMK2B,NEK4,INSR,CSNK1G1,CLK4,PLK3,CDC42BPA,MELK,NEK2,BRD4,MAPK7
,CLK3,MYO3A,RIOK1,GRK7,PLK1,MET,CAMK1D,STK10,PLK2,CIT,STK16,CSNK1G2,IRAK1,CDK7,CSNK1A1,TTK,DMPK,DAPK1,ABL1,BRDT,RPS6KA4,AAK1,HIPK1,TAOK3,HIPK2,MYLK,NIM1K,TAF1,GAK,CAMKK2,PIP4K2C,MAP3K19,CAMKK1,HIPK4,P
IK3CD,DAPK2,HUNK,CSNK1E,EIF2AK2,RPS6KA1,FLT3,MYO3B,STK33,NEK7,RPS6KA5,RPS6KA6,NEK3,PRKD1,RIOK3,CLK1,RPS6KA2,MAPK10,SYK,HIPK3,DCLK1,MERTK,CDK4,CAMK2A,LTK}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,Transferase,"Protein Kinase",Bromodomain,"CAMK protein kinase group","STE protein kinase group","AGC protein kinase group","CK1 protein kinase group","TKL 
protein kinase group","TK protein kinase group","CMGC protein kinase group","Other protein kinase group","Atypical protein kinase group","CAMK protein kinase PHk family","STE protein kinase STE20 fami
ly","CAMK protein kinase CAMK2 family","CAMK protein kinase PKD family","CAMK protein kinase RAD53 family","AGC protein kinase PKC family","CK1 protein kinase CK1 family","TKL protein kinase STKR fami
ly","TKL protein kinase IRAK family","CAMK protein kinase DAPK family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Fer family","AGC protein kinase RSK family","CMGC protein kinase C
LK family","Tyrosine protein kinase Fak family","Other protein kinase NEK family","Tyrosine protein kinase InsR family","Other protein kinase PLK family","AGC protein kinase DMPK family","CAMK protein
 kinase CAMK1 family","CMGC protein kinase MAPK family","Atypical protein kinase RIO family","AGC protein kinase GRK family","Tyrosine protein kinase Met family","Other protein kinase NAK family","CMG
C protein kinase CDK family","Other protein kinase TTK family","Tyrosine protein kinase Abl family","CMGC protein kinase DYRK family","CAMK protein kinase MLCK family","Other protein kinase CAMKK fami
ly","STE protein kinase STE11 family","Other protein kinase PEK family","Tyrosine protein kinase PDGFR family","CAMK protein kinase unique family","Tyrosine protein kinase Syk family","CAMK protein ki
nase DCAMK1 family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Alk family","STE protein kinase TAO subfamily","STE protein kinase SLK subfamily","AGC protein kinase PKC alpha subfam
ily","CK1 protein kinase CK1-g","TKL protein kinase STKR Type 1 subfamily","STE protein kinase MSN subfamily","AGC protein kinase RSK subfamily","AGC protein kinase GEK subfamily","CAMK protein kinase
 MELK subfamily","CMGC protein kinase ERK5","STE protein kinase NinaC subfamily","Atypical protein kinase RIO1 subfamily","AGC protein kinase GRK subfamily","Other protein kinase PLK2","AGC protein ki
nase CRIK subfamily","CMGC protein kinase CDK7 subfamily","AGC protein kinase MSK subfamily","CMGC protein kinase HIPK subfamily","CAMK protein kinase NIM1 subfamily","Other protein kinase Meta subfam
ily","Other protein kinase PKR","Other protein kinase Nek1","Atypical protein kinase RIO3 subfamily","CMGC protein kinase JNK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets","Kinases (EC 2.7.x.x)","Catalytic receptors","Chromatin modifying enzymes","Bromodomain-containing proteins","CAMK: Calcium/calmodulin-dependent protein kina
ses","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase 1","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK famil
ies","Enzymatic bromodomain-containing proteins",Atypical,"Non-enzymatic BRD containing proteins","Lipid modifying kinases","Phosphorylase kinase (PHK) family","STE20 family","CAMK2 family","Protein k
inase D (PKD) family","CAMK-like (CAMKL) family","Protein kinase C (PKC) family","Casein kinase 1 (CK1) family","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Death-associated kinase (DAPK) family
","RSK family","CLK family","Other protein kinases","DMPK family","Bromodomain kinase (BRDK) family","Mitogen-activated protein kinases (MAP kinases)","RIO family","G protein-coupled receptor kinases 
(GRKs)","CAMK1 family","Cyclin-dependent kinase (CDK) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Myosin Light Chain Kinase (MLCK) family","TAF1 family","Ty
pe II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","CAMK-unique family","DCAMKL family","TAO subfamily","SLK subfamily","CH
K1 subfamily","Alpha subfamily","Receptor tyrosine kinases (RTKs)","Interleukin-1 receptor-associated kinase (IRAK) family","Non-receptor tyrosine kinases (nRTKs)","MSN subfamily","RSK subfamily","NIM
A (never in mitosis gene a)- related kinase (NEK) family","Polo-like kinase (PLK) family","GEK subfamily","MELK subfamily","ERK subfamily","NinaC subfamily","RIO1 subfamily","Opsin/rhodopsin kinases",
"Other DMPK family kinases","NAK family","CDK7 subfamily","TTK family","MSK subfamily","HIPK subfamily","NIM1 subfamily","Numb-associated kinase (NAK) family","CAMKK family","STE20 subfamily","HUNK su
bfamily","PEK family","RIO3 subfamily","JNK subfamily","CDK4 subfamily","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","
Fer family","Fak family","Type II RTKs: Insulin receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Abl family","Meta subfamily","Other PEK family kinases","Type III RTKs: 
PDGFR",CSFR,Kit,"FLT3 receptor family","Syk family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{Metabolism,"Cell Cycle","Neuronal System","Gene expression (Transcription)","Immune System","Programmed Cell Death","Signal Transduction","Cellular responses to external stimuli",Disease,"Development
al Biology","Metabolism of RNA","Muscle contraction","Vesicle-mediated transport",Hemostasis,"Metabolism of carbohydrates",Mitotic,"Transmission across Chemical Synapses","Metabolism of lipids","RNA P
olymerase II Transcription","Innate Immune System",Apoptosis,"Signaling by GPCR","Signaling by Receptor Tyrosine Kinases","Cellular responses to stress","Infectious disease","Nervous system developmen
t","Cytokine Signaling in Immune system","Intracellular signaling by second messengers","rRNA processing","Signaling by Rho GTPases","Diseases of signal transduction by growth factor receptors and sec
ond messengers","Cardiac conduction","Membrane Trafficking","Cell surface interactions at the vascular wall","Glycogen metabolism","M Phase","Neurotransmitter receptors and postsynaptic signal transmi
ssion","Sphingolipid metabolism","Generic Transcription Pathway","Toll-like Receptor Cascades","Caspase activation via extrinsic apoptotic signalling pathway","Mitotic G2-G2/M phases","GPCR downstream
 signalling","Signaling by SCF-KIT","Cellular Senescence","Leishmania infection","Axon guidance","Signaling by Interleukins","PIP3 activates AKT signaling","Regulation of mitotic cell cycle","SARS-CoV
 Infections","rRNA processing in the nucleus and cytosol","Neutrophil degranulation","RHO GTPase Effectors","HIV Infection","Signaling by WNT in cancer","Ion homeostasis","Clathrin-mediated endocytosi
s","trans-Golgi Network Vesicle Budding","Influenza Infection","Signaling by Insulin receptor","Mitotic G1 phase and G1/S transition","Glycogen breakdown (glycogenolysis)","Mitotic Metaphase and Anaph
ase","Activation of NMDA receptors and postsynaptic events","Sphingolipid de novo biosynthesis","Transcriptional Regulation by TP53","Glutamate binding","activation of AMPA receptors and synaptic plas
ticity","Toll Like Receptor 2 (TLR2) Cascade","Caspase activation via Dependence Receptors in the absence of ligand","G2/M Transition","G alpha (q) signalling events","Oxidative Stress Induced Senesce
nce","Toll Like Receptor 5 (TLR5) Cascade","Parasite infection","Semaphorin interactions","Interleukin-2 family signaling","Negative regulation of the PI3K/AKT network","APC/C-mediated degradation of 
cell cycle proteins","Potential therapeutics for SARS","Major pathway of rRNA processing in the nucleolus and cytosol","G alpha (i) signalling events","Leishmania parasite growth and survival","RHO GT
Pases activate CIT","HIV Life Cycle","Signaling by AMER1 mutants","L1CAM interactions","Cargo recognition for clathrin-mediated endocytosis","RHO GTPases activate PAKs","Golgi Associated Vesicle Bioge
nesis",Interleukin-3,"Interleukin-5 and GM-CSF signaling","NS1 Mediated Effects on Host Pathways","Insulin receptor signalling cascade","Mitotic Prophase","G1 Phase","Mitotic Anaphase","Post NMDA rece
ptor activation events","Regulation of TP53 Activity","Trafficking of AMPA receptors","Toll Like Receptor TLR6:TLR2 Cascade","Centrosome maturation","Gastrin-CREB signalling pathway via PKC and MAPK",
"MyD88 cascade initiated on plasma membrane","Leishmania phagocytosis","CRMPs in Sema3A signaling","Interleukin-2 signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Activation of APC/C and A
PC/C:Cdc20 mediated degradation of mitotic proteins","Visual phototransduction","Sema4D in semaphorin signaling","Anti-inflammatory response favouring Leishmania parasite infection","Late Phase of HIV
 Life Cycle","Truncations of AMER1 destabilize the destruction complex","Recycling pathway of L1","Interleukin receptor SHC signaling","Inhibition of PKR","IRS-mediated signalling","Nuclear Envelope B
reakdown","Cyclin D associated events in G1","Separation of Sister Chromatids","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Regulation of TP53 Expression and Deg
radation","Trafficking of GluR2-containing AMPA receptors","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Loss of proteins required for interphase microtubule organization from the centrosom
e","EGFR Transactivation by Gastrin","MAP kinase activation","FCGR3A-mediated phagocytosis","Regulation of TP53 Activity through Phosphorylation","APC/C:Cdc20 mediated degradation of mitotic proteins"
,"The phototransduction cascade","Sema4D mediated inhibition of cell attachment and migration","CD163 mediating an anti-inflammatory response","Transcription of the HIV genome","Activation of AMPK dow
nstream of NMDARs","Regulation of TP53 Activity through Acetylation","Activation of RAC1 downstream of NMDARs","PI3K Cascade","Activation of NIMA Kinases NEK9",NEK6,NEK7,"FCGR3A-mediated IL10 synthesi
s","Ras activation upon Ca2+ influx through NMDA receptor","Regulation of TP53 Degradation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","APC:Cdc20 med
iated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",Inactivation,"recovery and regulation of the phototransduction cascade","activated TAK1 mediates p38 MAPK ac
tivation","HIV Transcription Elongation","HIV Transcription Initiation","PI5P Regulates TP53 Acetylation","RSK activation","CREB phosphorylation","APC-Cdc20 mediated degradation of Nek2A","ERK/MAPK ta
rgets","Tat-mediated elongation of the HIV-1 transcript","Activation of the AP-1 family of transcription factors","ERKs are inactivated","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{BRD4,PLK1,PLK2,PLK3}

> <broad_moa>
{"PLK inhibitor"}

> <synonyms>
{"BI 2536",755038-02-9,755038029,BI-2536,BI2536,UNII-4LJG22T9C6,UNII4LJG22T9C6,(R)-BI-2536,(R)BI2536,4LJG22T9C6,CHEMBL513909,C28H39N7O3,"US8598172, 5",R78,PubChem22397,cc-627,cc627,MLS006011060,SCHEMB
L372489,GTPL5666,BDBM25121,AOB1365,DTXSID20226442,SYN1019,BCPP000342,AMY24180,EX-A2350,EXA2350,T6173,S1109}

> <pdid>
PD003209

> <targets>
{PLK,PLK1}

> <classes>
{}

> <pubchem_cids>
{11364421}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  0  0            999 V2000
    0.4512   -8.1382    0.0000 C   0  0
   -0.9618   -8.6416    0.0000 C   0  0
   -2.1046   -7.6686    0.0000 O   0  0
   -1.8348   -6.1949    0.0000 C   0  0
   -0.4810   -5.5489    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1519   -3.7886    0.0000 S   0  0
   -2.8675   -5.1069    0.0000 C   0  0
   -4.3533   -5.2996    0.0000 C   0  0
   -4.9296   -6.6845    0.0000 N   0  0
   -5.2649   -4.1084    0.0000 O   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 N   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 N   0  0
   -7.7884   -1.5181    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2321  -10.1179    0.0000 C   0  0
   -2.6460  -10.6189    0.0000 C   0  0
   -2.9191  -12.0938    0.0000 C   0  0
   -1.7784  -13.0678    0.0000 C   0  0
   -0.3645  -12.5668    0.0000 C   0  0
   -0.0914  -11.0919    0.0000 C   0  0
    1.3233  -10.5907    0.0000 C   0  0
    2.4647  -11.5640    0.0000 F   0  0
    1.5960   -9.1157    0.0000 F   0  0
    2.7370  -10.0892    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  4  2  0
  8  9  1  0
  9 10  1  0
  9 11  2  0
  6 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 25 26  1  0
 26 20  1  0
 18 27  1  0
 27 28  2  0
 28 12  1  0
 28 15  1  0
  2 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 29  1  0
 34 35  1  0
 35 36  1  0
 35 37  1  0
 35 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28462

> <plate>
Kinase v5-2

> <well>
K17

> <supplier_cmpd_name>
GSK461364

> <ctcr_id>
980

> <supplier_cmpd_id>
S2193

> <smiles>
CC(Oc1cc(sc1C(N)=O)n2cnc3ccc(CN4CCN(C)CC4)cc23)c5ccccc5C(F)(F)F

> <pd_targets>
{PRKD3,CSNK2A2,PIK3CG,BRSK2,MAP3K19,NIM1K,RPS6KA3,PLK3,IRAK1,FLT3,ROCK1,PIK3CB,PKN2,MERTK,IRAK3,RPS6KA6,NUAK2,RIOK1,DAPK1,STK10,DAPK3,CSNK2A1,NEK2,PIK3C2B,GRK4,PLK2,DAPK2,MAP3K9,GRK7,CAMK2D,KIT,PIP5K1
A,PRKCI,NEK5,RPS6KA4,ULK2,NEK9,PIM3,TAOK3,MAP3K1,RPS6KA2,CDK7,PDGFRB,PIM1,RIOK3,TIE1,NEK1,SLK,CAMK2A,MAP4K2,PIK3CD,EIF2AK4,CAMK2B,PIP4K2B,ANKK1,PLK1,PIP5K1C,CAMK2G,SRPK3,BMP2K,PRKCD}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","CAMK protein kinase group","Other protein kinase group","STE protein kinase group","AGC protein kinase group","TKL protein kinase group","TK protein kinase
 group","Atypical protein kinase group","CMGC protein kinase group","CAMK protein kinase PKD family","Other protein kinase CK2 family","CAMK protein kinase CAMK1 family","STE protein kinase STE11 fami
ly","AGC protein kinase RSK family","Other protein kinase PLK family","TKL protein kinase IRAK family","Tyrosine protein kinase PDGFR family","AGC protein kinase DMPK family","AGC protein kinase PKN f
amily","Tyrosine protein kinase Axl family","Atypical protein kinase RIO family","CAMK protein kinase DAPK family","STE protein kinase STE20 family","Other protein kinase NEK family","AGC protein kina
se GRK family","TKL protein kinase MLK family","CAMK protein kinase CAMK2 family","AGC protein kinase PKC family","Other protein kinase ULK family","CAMK protein kinase PIM family","CMGC protein kinas
e CDK family","Tyrosine protein kinase Tie family","Other protein kinase PEK family","TKL protein kinase RIPK family","CMGC protein kinase SRPK family","Other protein kinase NAK family","CAMK protein 
kinase BRSK subfamily","CAMK protein kinase NIM1 subfamily","AGC protein kinase RSK subfamily","AGC protein kinase ROCK subfamily","CAMK protein kinase NuaK subfamily","Atypical protein kinase RIO1 su
bfamily","STE protein kinase SLK subfamily","AGC protein kinase GRK subfamily","Other protein kinase PLK2","TKL protein kinase MLK subfamily","AGC protein kinase PKC iota subfamily","AGC protein kinas
e MSK subfamily","STE protein kinase TAO subfamily","CMGC protein kinase CDK7 subfamily","Atypical protein kinase RIO3 subfamily","STE protein kinase KHS subfamily","Other protein kinase GCN2 subfamil
y","AGC protein kinase PKC delta subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","Lipid modifying kinases","STE: Homologs of yeast Sterile 7","St
erile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families",Atypical,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","Protein kinase D (PKD) family","Other protein kinases",Phosphatidylino
sitol-4,"5-bisphosphate 3-kinase family","CAMK-like (CAMKL) family","STE20 family","RSK family","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","DMPK family","Protein kinase N (PKN) family","RIO fam
ily","Death-associated kinase (DAPK) family","Phosphatidylinositol-4-phosphate 3-kinase family","G protein-coupled receptor kinases (GRKs)","CAMK2 family","Type I PIP kinases (1-phosphatidylinositol-4
-phosphate 5-kinase family)","Protein kinase C (PKC) family","PIM family","STE11 family","Cyclin-dependent kinase (CDK) family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family
)","SRPK family","Casein kinase 2 (CK2) family","BRSK subfamily","STE20 subfamily","NIM1 subfamily","RSK subfamily","Polo-like kinase (PLK) family","Interleukin-1 receptor-associated kinase (IRAK) fam
ily","Receptor tyrosine kinases (RTKs)","Rho kinase","NuaK subfamily","RIO1 subfamily","SLK subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","GRK4 subfamily","Mixed Lineage Kin
ase (MLK) family","Opsin/rhodopsin kinases","Iota subfamily","MSK subfamily","Unc-51-like kinase (ULK) family","TAO subfamily","CDK7 subfamily","RIO3 subfamily","KHS subfamily","PEK family","Receptor 
interacting protein kinase (RIPK) family","Numb-associated kinase (NAK) family","Delta subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) r
eceptor family","MLK subfamily","Type XII RTKs: TIE family of angiopoietin receptors","GCN2 subfamily"}

> <pathway_reactome>
{Metabolism,"Gene expression (Transcription)","Immune System","Signal Transduction","Developmental Biology",Hemostasis,"Neuronal System","Metabolism of RNA","Programmed Cell Death","Cell Cycle",Diseas
e,"Cellular responses to external stimuli","Metabolism of lipids","RNA Polymerase II Transcription","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Nervous system development","Signal
ing by Rho GTPases","Cell surface interactions at the vascular wall","Transmission across Chemical Synapses","rRNA processing",Apoptosis,Mitotic,"Signaling by GPCR","Infectious disease","Diseases of s
ignal transduction by growth factor receptors and second messengers","Death Receptor Signalling","Intracellular signaling by second messengers","Cytokine Signaling in Immune system","Cellular response
s to stress","Sphingolipid metabolism","Generic Transcription Pathway","Phospholipid metabolism","Toll-like Receptor Cascades","Signaling by Insulin receptor","Axon guidance","RHO GTPase Effectors","N
eurotransmitter receptors and postsynaptic signal transmission","rRNA processing in the nucleus and cytosol","Caspase activation via extrinsic apoptotic signalling pathway","Neutrophil degranulation",
"Regulation of mitotic cell cycle","GPCR downstream signalling","Leishmania infection","Signaling by KIT in disease","p75 NTR receptor-mediated signalling","M Phase","HIV Infection","PIP3 activates AK
T signaling","FLT3 signaling in disease","Signaling by Interleukins","Response of EIF2AK4 (GCN2) to amino acid deficiency","Mitotic G2-G2/M phases","DAG and IP3 signaling","Sphingolipid de novo biosyn
thesis","Transcriptional Regulation by TP53","PI Metabolism","Toll Like Receptor 5 (TLR5) Cascade","Insulin receptor signalling cascade","Semaphorin interactions","RHO GTPases activate PKNs","Toll Lik
e Receptor 2 (TLR2) Cascade","Activation of NMDA receptors and postsynaptic events","Major pathway of rRNA processing in the nucleolus and cytosol","Caspase activation via Dependence Receptors in the 
absence of ligand","APC/C-mediated degradation of cell cycle proteins","G alpha (i) signalling events","Leishmania parasite growth and survival","Drug resistance of KIT mutants","p75NTR signals via NF
-kB","L1CAM interactions","Mitotic Prophase","HIV Life Cycle","Negative regulation of the PI3K/AKT network","Signaling by FLT3 ITD and TKD mutants",Interleukin-3,"Interleukin-5 and GM-CSF signaling","
G2/M Transition","CaM pathway","Regulation of TP53 Activity","Synthesis of PIPs at the plasma membrane","MyD88 cascade initiated on plasma membrane","IRS-mediated signalling","Sema4D in semaphorin sig
naling","Toll Like Receptor TLR6:TLR2 Cascade","Post NMDA receptor activation events","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Visual phototransduction","Anti-in
flammatory response favouring Leishmania parasite infection","Dasatinib-resistant KIT mutants","p75NTR recruits signalling complexes","Recycling pathway of L1","Nuclear Envelope Breakdown","Late Phase
 of HIV Life Cycle",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","STAT5 activation downstream of FLT3 ITD mutants","Interleukin receptor SHC signaling","Centrosome maturation","SEMA3A-Plexin repul
sion signaling by inhibiting Integrin adhesion","Calmodulin induced events","Regulation of TP53 Activity through Phosphorylation","MAP kinase activation","PI3K Cascade","Sema4D induced cell migration 
and growth-cone collapse","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","APC/C:Cdc20 mediated degradation o
f mitotic proteins","The phototransduction cascade","CD163 mediating an anti-inflammatory response","Activation of NIMA Kinases NEK9",NEK6,NEK7,"Transcription of the HIV genome","Regulation of TP53 Ac
tivity through Acetylation","Loss of proteins required for interphase microtubule organization from the centrosome","MAPK targets/ Nuclear events mediated by MAP kinases","activated TAK1 mediates p38 
MAPK activation","RSK activation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",Inactivation,"recovery and regulation of the phototransducti
on cascade","Ras activation upon Ca2+ influx through NMDA receptor","HIV Transcription Elongation","PI5P Regulates TP53 Acetylation","Loss of Nlp from mitotic centrosomes","CREB phosphorylation","APC-
Cdc20 mediated degradation of Nek2A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{PLK1}

> <broad_moa>
{"PLK inhibitor"}

> <synonyms>
{GSK461364A,929095-27-2,929095272,SCHEMBL4276841,CALCIUMNITRATETETRAHYDRATE,"PLK1 inhibitor GSK461364",CHEMBL2144434,HMS3265C05,HMS3265C06,HMS3265D05,HMS3265D06,HMS3655L08,AKOS032947267,NCGC00387842-0
1,NCGC0038784201,AK-43764,AK43764,FT-0772568,FT0772568,T6282,S2193,GSK461364}

> <pdid>
PD003618

> <targets>
{PLK,"Polo-like Kinase (PLK)"}

> <classes>
{Cell Cycle,Cell Cycle/DNA Damage}

> <pubchem_cids>
{44555147}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 32  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 N   0  0
   -1.3018    3.7547    0.0000 C   0  0
   -0.0012    3.0074    0.0000 C   0  0
   -1.3044    5.2547    0.0000 O   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -5.1971    2.9990    0.0000 C   0  0
   -6.4977    3.7464    0.0000 C   0  0
   -6.5007    5.2464    0.0000 C   0  0
   -5.2032    5.9990    0.0000 C   0  0
   -3.9027    5.2517    0.0000 C   0  0
   -2.6060    6.0074    0.0000 C   0  0
   -2.6113    7.5082    0.0000 C   0  0
   -1.3146    8.2640    0.0000 C   0  0
   -1.3177    9.7641    0.0000 C   0  0
   -0.0202   10.5168    0.0000 C   0  0
    1.2804    9.7695    0.0000 N   0  3
    2.5779   10.5222    0.0000 O   0  5
    1.2835    8.2695    0.0000 C   0  0
   -0.0139    7.5168    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  6  9  1  0
  9 10  2  0
  9 11  2  0
  9 12  1  0
 12 13  1  0
 13 14  1  0
 13 15  2  0
 12 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 21 22  1  0
 22 23  2  3
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 27 29  1  0
 29 30  2  0
 30 24  1  0
M  CHG  2  27   1  28  -1
M  END
> <name>
UTKinase_V5

> <id>
28463

> <plate>
Kinase v5-2

> <well>
K19

> <supplier_cmpd_name>
HMN-214

> <ctcr_id>
3513

> <supplier_cmpd_id>
S1485

> <smiles>
COc1ccc(cc1)[S](=O)(=O)N(C(C)=O)c2ccccc2C=Cc3cc[n+]([O-])cc3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{PLK1}

> <broad_moa>
{"PLK inhibitor"}

> <synonyms>
{HMS3654N14,HMS3672K15,AKOS026750486,AK232286,DB-064912,DB064912,FT-0772787,FT0772787,Q27163286,T2438,S1485,HMN214,HMN-214}

> <pdid>
PD003390

> <targets>
{PLK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{54143018}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 32  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 O   0  0
    1.3032    3.7490    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 S   0  0
   -5.2029    2.9932    0.0000 O   0  0
   -3.9027    2.2457    0.0000 O   0  0
   -6.4990    0.7409    0.0000 C   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0994    0.7387    0.0000 C   0  0
  -10.3984    1.4886    0.0000 C   0  0
  -10.3985    2.9886    0.0000 C   0  0
  -11.6998    3.7364    0.0000 O   0  0
  -12.9978    2.9845    0.0000 C   0  0
   -9.0995    3.7387    0.0000 C   0  0
   -9.0964    5.2395    0.0000 N   0  0
   -7.7956    5.9881    0.0000 C   0  0
   -7.7926    7.4889    0.0000 C   0  0
   -9.0903    8.2412    0.0000 O   0  0
   -6.4925    8.2371    0.0000 O   0  0
   -7.8004    2.9887    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 O   0  0
   -2.5951   -3.0031    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  5  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 11 13  2  0
 11 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 18 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 21 27  2  0
 27 15  1  0
  8 28  1  0
 28 29  1  0
 29 30  1  0
 28 31  2  0
 31  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28464

> <plate>
Kinase v5-2

> <well>
K21

> <supplier_cmpd_name>
ON-01910

> <ctcr_id>
8277

> <supplier_cmpd_id>
S1362

> <smiles>
COc1cc(OC)c(\C=C\[S](=O)(=O)Cc2ccc(OC)c(NCC(O)=O)c2)c(OC)c1

> <pd_targets>
{PLK1,PIK3CA,F2R}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor",Kinase,Transferase,"Family A G protein-coupled receptor","Protein Kinase","Peptide receptor (family A GPCR)","Other protein kinase group","Protease-activated receptor","Oth
er protein kinase PLK family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","G protein-coupled receptors","Receptor kinases","Lipid modifying kinases","Proteinase-activated receptors","Other protein kinases",Phos
phatidylinositol-4,"5-bisphosphate 3-kinase family","Polo-like kinase (PLK) family"}

> <pathway_reactome>
{"Cell Cycle",Disease,"Signal Transduction",Mitotic,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by GPCR","Mitotic G2-G2/M phases","Signaling by FGFR i
n disease","GPCR ligand binding","G2/M Transition","Signaling by FGFR1 in disease","Class A/1 (Rhodopsin-like receptors)","Centrosome maturation","FGFR1 mutant receptor activation","Peptide ligand-bin
ding receptors","Loss of proteins required for interphase microtubule organization from the centrosome","Signaling by cytosolic FGFR1 fusion mutants","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{PLK1}

> <broad_moa>
{"cell cycle inhibitor","PLK inhibitor"}

> <synonyms>
{Rigosertib,592542-59-1,592542591,UNII-67DOW7F9GL,UNII67DOW7F9GL,"ON 01910",ON-01910,ON01910,67DOW7F9GL,ON-01910.Na,ON01910.Na,"Rigosertib (USAN:INN)",rigosertibum,6FS,"Rigosertib (USAN)","Estybon (pr
oposed trade name)",SCHEMBL498623,SCHEMBL498624,GTPL7833,CHEMBL1241855,DTXSID3,"HY- 12037A",Rigosertib}

> <pdid>
PD003419

> <targets>
{Apoptosis,PI3K,Polo-like Kinase (PLK)}

> <classes>
{Apoptosis,Cell Cycle/DNA Damage,PI3K/Akt/mTOR}

> <pubchem_cids>
{6918736}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Cl  0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 C   0  0
   -1.2946   -3.7531    0.0000 O   0  0
    1.3039   -3.7494    0.0000 N   0  0
    1.3070   -5.2502    0.0000 C   0  0
    0.0935   -6.1101    0.0000 C   0  0
    0.5570   -7.5366    0.0000 N   0  0
    2.0570   -7.5366    0.0000 N   0  0
    2.5205   -6.1100    0.0000 C   0  0
    3.9428   -5.6391    0.0000 C   0  0
    4.2459   -4.1700    0.0000 O   0  0
    5.0644   -6.6363    0.0000 N   0  0
    6.4891   -6.1645    0.0000 C   0  0
    7.6116   -7.1595    0.0000 C   0  0
    9.0346   -6.6851    0.0000 C   0  0
    9.3352   -5.2155    0.0000 N   0  0
    8.2128   -4.2204    0.0000 C   0  0
    6.7898   -4.6948    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 12  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28465

> <plate>
Kinase v5-2

> <well>
M03

> <supplier_cmpd_name>
AT7519

> <ctcr_id>
2199

> <supplier_cmpd_id>
S1524

> <smiles>
Clc1cccc(Cl)c1C(=O)Nc2c[nH]nc2C(=O)NC3CCNCC3

> <pd_targets>
{TLK1,TAOK2,TAOK3,CLK2,DYRK1B,CDK2,CDK7,CDK9,CCNA1,CCNA2,DMPK,CDK17,DCLK3,CDK16,TAOK1,CDK5,SLK,CDK3,DYRK2,DCLK2,CCND1,CDK4,CDK5R1,CDK11B,DYRK1A,CAMKK2,CILK1,CLK4,MAK,CDK14,CDK19,CDK13,MAPK7,GSK3B,CDK1
1A,MAPK15,CLK1,CDK18,CASK,CLK3,CCNY,CDKL2,GSK3A,CDKL5,CCND3,CDK6,CDK15,CCNB1,CDK1,CCNE1,CCNH,MNAT1,CDK10,CDK12,CDK20,CDK8}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","STE protein kinase group","CMGC protein kinase group","AGC protein kinase group","CAMK protein kinase group","Other protein kinase TLK fam
ily","STE protein kinase STE20 family","CMGC protein kinase CLK family","CMGC protein kinase DYRK family","CMGC protein kinase CDK family","AGC protein kinase DMPK family","CAMK protein kinase DCAMK1 
family","Other protein kinase CAMKK family","CMGC protein kinase RCK family","CMGC protein kinase MAPK family","CMGC protein kinase GSK family","CMGC protein kinase CDKL family","STE protein kinase TA
O subfamily","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","AGC protein kinase GEK subfamily","CM
GC protein kinase PCTAIRE","CMGC protein kinase TAIRE subfamily","CMGC protein kinase CDK5 subfamily","STE protein kinase SLK subfamily","CMGC protein kinase Dyrk2 subfamily","CMGC protein kinase PITS
LRE subfamily","Other protein kinase Meta subfamily","CMGC protein kinase MAK","CMGC protein kinase PFTAIRE","CMGC protein kinase CDK8 subfamily","CMGC protein kinase ERK5"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families",
"AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","STE20 family","CLK family","Dual-specificity tyrosine-(Y)-phosphorylation regulat
ed kinase (DYRK) family","Cyclin-dependent kinase (CDK) family","DMPK family","DCAMKL family","RCK family","Mitogen-activated protein kinases (MAP kinases)","Glycogen synthase kinase (GSK) family","CA
SK family","Cyclin-dependent kinase-like (CDKL) family","Tousled-like kinase (TLK) family","TAO subfamily","Dyrk1 subfamily","CDK1 subfamily","CDK7 subfamily","CDK9 subfamily","GEK subfamily","TAIRE s
ubfamily","CDK5 subfamily","SLK subfamily","Dyrk2 subfamily","PITSLRE subfamily","CDK4 subfamily","CAMKK family","CDK8 subfamily","CRK7 subfamily","ERK subfamily","GSK subfamily","Erk7 subfamily","Met
a subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,"Muscle contraction","Cell Cycle","Neuronal System",Metabolism,"Immune System","RNA Polymerase II Transcription","Infectious disease","Cardiac conduction",Mi
totic,"Transmission across Chemical Synapses","Metabolism of lipids","Innate Immune System","Generic Transcription Pathway","HIV Infection","Ion homeostasis","M Phase","Mitotic G2-G2/M phases","Mitoti
c G1 phase and G1/S transition","Neurotransmitter receptors and postsynaptic signal transmission","Regulation of lipid metabolism by PPARalpha","Toll-like Receptor Cascades","SARS-CoV Infections","Reg
ulation of mitotic cell cycle","Transcriptional Regulation by TP53","HIV Life Cycle","Mitotic Metaphase and Anaphase","G2/M Transition","G1 Phase","G0 and Early G1","Activation of NMDA receptors and p
ostsynaptic events","PPARA activates gene expression","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-1 Infection","APC/C-mediated degradation of cell cycle proteins","Regulation of TP53 Activity","La
te Phase of HIV Life Cycle","Mitotic Anaphase","Centrosome maturation","Cyclin D associated events in G1","Post NMDA receptor activation events","TP53 Regulates Transcription of DNA Repair Genes","MyD
88 cascade initiated on plasma membrane","SARS-CoV-1 Genome Replication and Transcription","Assembly and cell surface presentation of NMDA receptors","Activation of APC/C and APC/C:Cdc20 mediated degr
adation of mitotic proteins","Regulation of TP53 Expression and Degradation","Transcription of the HIV genome","Separation of Sister Chromatids","Regulation of TP53 Activity through Phosphorylation","
Recruitment of mitotic centrosome proteins and complexes","Activation of AMPK downstream of NMDARs","MAP kinase activation","Replication of the SARS-CoV-1 genome","APC/C:Cdc20 mediated degradation of 
mitotic proteins","Regulation of TP53 Degradation","HIV Transcription Elongation","MAPK targets/ Nuclear events mediated by MAP kinases","APC:Cdc20 mediated degradation of cell cycle proteins prior to
 satisfation of the cell cycle checkpoint","Tat-mediated elongation of the HIV-1 transcript","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Formation of HIV-1 elongation co
mplex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{LZE,AT7519,844442-38-2,844442382,AT-7519,"AT 7519","4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide","4(2,6dichlorobenzamido)N(piperidin4yl)1Hpyrazole3carboxamide",UNII-X1BF92P
W9T,UNIIX1BF92PW9T,"N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide","N(4Piperidinyl)4(2,6dichlorobenzoylamino)1Hpyrazole3carboxamide","AT-7519 free base","AT7519 free base",X
1BF92PW9T,4-((2,4((2,6-dic,6dic,S1524,SY-AT-7519}

> <pdid>
PD004706

> <targets>
{CDK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{11338033}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 30  0  0  0  0            999 V2000
    8.9915    0.2493    0.0000 Cl  0  0
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8933    3.7570    0.0000 C   0  0
    3.8933    5.2571    0.0000 C   0  0
    5.1924    6.0071    0.0000 C   0  0
    6.4914    5.2571    0.0000 C   0  0
    6.4915    3.7571    0.0000 C   0  0
    5.1925    3.0071    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4990    0.7409    0.0000 C   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0990    0.7364    0.0000 C   0  0
  -10.4003    1.4841    0.0000 C   0  0
  -11.6982    0.7323    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
  9 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 19 28  2  0
 28 29  1  0
 29  5  2  0
 29  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28466

> <plate>
Kinase v5-2

> <well>
M05

> <supplier_cmpd_name>
BS-181 HCl

> <ctcr_id>
6885

> <supplier_cmpd_id>
S1572

> <smiles>
Cl.CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12

> <pd_targets>
{CDK7,CDK2,CDK5,CDK1,CDK9,CDK4,CCNH,MNAT1,CDK5R1,CDK6,CCND1,CCNT1,CDK8,CCNB1,CCNE1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfami
ly","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK8 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK7 subfamily","CDK1 subfamily","CDK5 subfamily","CDK9 subfamily","CDK4 subfami
ly","CDK8 subfamily"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Cell Cycle","Infectious disease","RNA Polymerase II Transcription",Mitotic,"Diseases of signal transduction by growth factor receptors and second messengers
","HIV Infection","Generic Transcription Pathway","Regulation of mitotic cell cycle","Mitotic G1 phase and G1/S transition","Signaling by NOTCH1 in Cancer","HIV Life Cycle","Transcriptional Regulation
 by TP53","APC/C-mediated degradation of cell cycle proteins","G1 Phase","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Late Phase of HIV Life Cycle","Regulation of TP53 Activity","Activation
 of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Cyclin D associated events in G1","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Transcription of the HIV genome","Regu
lation of TP53 Expression and Degradation","Regulation of TP53 Activity through Phosphorylation","APC/C:Cdc20 mediated degradation of mitotic proteins","HIV Transcription Elongation","Regulation of TP
53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Tat-mediated elongation of the HIV-1 transcript","Cdc20:Phospho-APC/C mediate
d degradation of Cyclin A","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{CDK7}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{"S181 HC","BS-181 HCl","BS181 HCl","BS-181 hydrochloride","BS181 hydrochloride",1397219-81-6,1397219816,"BS-181 (hydrochloride)","BS181 (hydrochloride)",BS181,"1397219-81-6 (HCl)","1397219816 (HCl)",
C22H32N6,"BS 181","BS 181 hydrochloride",cc-578,cc578,MLS006011030,SCHEMBL15757472,AOB6697,BCPP000314,EX-A2036,EXA2036,HY-13266A,HY13266A,s1572,AKOS027422739,BCP900,T6162,S1572}

> <pdid>
PD017549

> <targets>
{CDK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{49867928}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    2.5951   -3.0031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.8994    3.7477    0.0000 N   0  0
   -5.1981    2.9954    0.0000 C   0  0
   -6.4998    3.7409    0.0000 C   0  0
   -7.7962    2.9864    0.0000 C   0  0
   -7.7910    1.4864    0.0000 C   0  0
   -6.4894    0.7409    0.0000 C   0  0
   -5.1930    1.4954    0.0000 N   0  0
   -9.0881    0.7315    0.0000 N   0  0
  -10.3910    1.4749    0.0000 C   0  0
  -11.6862    0.7183    0.0000 C   0  0
  -11.6787   -0.7816    0.0000 N   0  0
  -10.3758   -1.5251    0.0000 C   0  0
   -9.0806   -0.7685    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.9511   -0.8815    0.0000 C   0  0
   -4.9530   -1.9978    0.0000 C   0  0
   -4.2010   -3.2957    0.0000 C   0  0
   -2.7343   -2.9815    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  3
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
 10 24  1  0
 24 25  2  0
 25  7  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 27  1  0
 26 32  1  0
 32  4  1  0
 32 33  2  0
M  END
> <name>
UTKinase_V5

> <id>
28467

> <plate>
Kinase v5-2

> <well>
M07

> <supplier_cmpd_name>
PD0332991

> <ctcr_id>
3109

> <supplier_cmpd_id>
S1116

> <smiles>
CC(=O)C1=C(C)c2cnc(Nc3ccc(cn3)N4CCNCC4)nc2N(C5CCCC5)C1=O

> <pd_targets>
{DAPK3,CHEK1,CLK4,LRRK2,CCND1,CCND2,CCND3,CDK4,FLT3,CDK6,CDK9,PRKX,NEK2,PRKD3,MAP4K5,CCNT1,CDK2,JAK3,CLK2,MST1R,PRKAA1,MAP4K4,DYRK1A,DYRK1B,TAOK1,CDK5,RPS6KA3,MAPK9,CCNA2,MAP4K2,ROCK2,PAK4,ALK,RET,MET
,MAPK8,CCNB1,CDK1,CCNE1,TTK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CMGC protein kinase group","TKL protein kinase group","TK protein kinase group","AGC protein kinase group","Other protein kinase group","ST
E protein kinase group","CAMK protein kinase DAPK family","CAMK protein kinase CAMK1 family","CMGC protein kinase CLK family","TKL protein kinase LRRK family","Tyrosine protein kinase PDGFR family","C
MGC protein kinase CDK family","AGC protein kinase PKA family","Other protein kinase NEK family","CAMK protein kinase PKD family","STE protein kinase STE20 family","Tyrosine protein kinase JakA family
","Tyrosine protein kinase Met family","CMGC protein kinase DYRK family","AGC protein kinase RSK family","CMGC protein kinase MAPK family","AGC protein kinase DMPK family","TKL protein kinase STKR fam
ily","Tyrosine protein kinase Ret family","Other protein kinase TTK family","CAMK protein kinase CHK1 subfamily","CMGC protein kinase CDK9 subfamily","STE protein kinase KHS subfamily","CMGC protein k
inase CDC2 subfamily","CAMK protein kinase AMPK subfamily","STE protein kinase MSN subfamily","CMGC protein kinase Dyrk1 subfamily","STE protein kinase TAO subfamily","CMGC protein kinase CDK5 subfami
ly","AGC protein kinase RSK subfamily","CMGC protein kinase JNK subfamily","AGC protein kinase ROCK subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","AGC: Containing
 PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Death-associated kinase (DAPK) family","CAMK-like (CAMKL) family","CLK family","TKL: Tyrosine kinase-like
","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","Protein kinase A (PKA) family","Other protein kinases","Protein kinase D (PKD) family","STE20 family","Dual-specificity tyrosine-(Y)-pho
sphorylation regulated kinase (DYRK) family","RSK family","Mitogen-activated protein kinases (MAP kinases)","DMPK family","CHK1 subfamily","Leucine-rich repeat kinase (LRRK) family","Receptor tyrosine
 kinases (RTKs)","CDK4 subfamily","CDK9 subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","KHS subfamily","CDK1 subfamily","Non-receptor tyrosine kinases (nRTKs)","AMPK subfamil
y","MSN subfamily","Dyrk1 subfamily","TAO subfamily","CDK5 subfamily","RSK subfamily","JNK subfamily","Rho kinase","PAKB subfamily","TTK family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family",
"Janus kinase (JakA) family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XIV RTKs: RET"}

> <pathway_reactome>
{"Programmed Cell Death","DNA Repair","Signal Transduction","Cell Cycle",Disease,Metabolism,"Gene expression (Transcription)","Immune System","Cellular responses to external stimuli","Developmental Bi
ology",Apoptosis,"DNA Double-Strand Break Repair","Signaling by Non-Receptor Tyrosine Kinases","Signaling by Receptor Tyrosine Kinases",Mitotic,"Infectious disease","Metabolism of lipids","RNA Polymer
ase II Transcription","Cytokine Signaling in Immune system","Cellular responses to stress","Innate Immune System","Nervous system development","Caspase activation via extrinsic apoptotic signalling pa
thway","Homology Directed Repair","Signaling by PTK6","Signaling by Insulin receptor","Mitotic G1 phase and G1/S transition","HIV Infection","Leishmania infection","Regulation of mitotic cell cycle","
Sphingolipid metabolism","Generic Transcription Pathway","Signaling by Interleukins","Signaling by MST1","Cellular Senescence","M Phase","Toll-like Receptor Cascades","Axon guidance","Caspase activati
on via Dependence Receptors in the absence of ligand","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","PTK6 promotes HIF1A stabilization","Insulin receptor signalling cas
cade","G1 Phase","HIV Life Cycle","Leishmania parasite growth and survival","APC/C-mediated degradation of cell cycle proteins","Sphingolipid de novo biosynthesis","Transcriptional Regulation by TP53"
,"Interleukin-2 family signaling","Oxidative Stress Induced Senescence","G0 and Early G1","Mitotic Metaphase and Anaphase","Toll Like Receptor 5 (TLR5) Cascade","Semaphorin interactions","Signaling by
 ROBO receptors","RET signaling","HDR through Homologous Recombination (HRR)","IRS-mediated signalling","Cyclin D associated events in G1","Late Phase of HIV Life Cycle","Anti-inflammatory response fa
vouring Leishmania parasite infection","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity","Interleukin-15 signaling","Mitotic Anaphase","MyD88
 cascade initiated on plasma membrane","Sema4D in semaphorin signaling","Activation of RAC1","Homologous DNA Pairing and Strand Exchange","PI3K Cascade","Transcription of the HIV genome","ADORA2B medi
ated anti-inflammatory cytokines production","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Expression and Degradation","Regulation of TP53 Activity through Phosphorylation
","Separation of Sister Chromatids","MAP kinase activation","Sema4D induced cell migration and growth-cone collapse","Sema4D mediated inhibition of cell attachment and migration","Presynaptic phase of
 homologous DNA pairing and strand exchange","HIV Transcription Elongation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Regulation of TP5
3 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","Tat-mediated elongation of the HIV-1 transcript","APC-Cdc20 mediated degradation of Nek2A","CREB phosphorylation","Activation of 
the AP-1 family of transcription factors","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{CDK4,CDK6}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{Palbociclib,571190-30-2,571190302,PD0332991,Ibrance,PD-0332991,"PD 0332991",UNII-G9ZF61LE7G,UNIIG9ZF61LE7G,"Palbociclib free base",Palbociclib-d8,Palbociclibd8,PD-332991,PD332991,"571190-30-2 (free b
ase)","571190302 (free base)",MFCD11840850,G9ZF61LE7G,Palbociclib(PD0332991),"PD 332991",CHEBI:85993,(d8)-Palbociclib,(d8)Palbociclib,T1785,T6239,758247,S1116,"Palbociclib hydrochloride"}

> <pdid>
PD003263

> <targets>
{CDK}

> <classes>
{}

> <pubchem_cids>
{5330286}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    6.3868   -4.3485    0.0000 C   0  0
    5.5026   -3.1368    0.0000 C   0  0
    6.1103   -1.7655    0.0000 C   0  0
    4.0102   -3.2959    0.0000 C   0  0
    3.1255   -2.0835    0.0000 C   0  0
    3.7332   -0.7121    0.0000 O   0  0
    1.6332   -2.2426    0.0000 N   0  0
    0.7500   -1.0323    0.0000 C   0  0
    1.2135    0.3943    0.0000 N   0  0
    0.0000    1.2760    0.0000 N   0  0
   -1.2135    0.3943    0.0000 C   0  0
   -0.7500   -1.0323    0.0000 C   0  0
   -1.9615   -1.9133    0.0000 C   0  0
   -3.1750   -1.0316    0.0000 N   0  0
   -4.5990   -1.4976    0.0000 C   0  0
   -5.7155   -0.4959    0.0000 O   0  0
   -4.9089   -2.9661    0.0000 C   0  0
   -6.3339   -3.4347    0.0000 C   0  0
   -6.6406   -4.9030    0.0000 C   0  0
   -5.5224   -5.9028    0.0000 N   0  0
   -5.8292   -7.3711    0.0000 C   0  0
   -4.0975   -5.4343    0.0000 C   0  0
   -3.7907   -3.9660    0.0000 C   0  0
   -2.7115    0.3949    0.0000 C   0  0
   -2.0807    1.7558    0.0000 C   0  0
   -4.2009    0.2164    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12  8  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 22 23  1  0
 23 17  1  0
 14 24  1  0
 24 11  1  0
 24 25  1  0
 24 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28468

> <plate>
Kinase v5-2

> <well>
M09

> <supplier_cmpd_name>
PHA-793887

> <ctcr_id>
579

> <supplier_cmpd_id>
S1487

> <smiles>
CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C3CCN(C)CC3)C2(C)C

> <pd_targets>
{CCNE1,CDK2,CCNH,CDK7,CCND1,CDK4,GSK3B,CCNT1,CDK9,CCNA1,CCNA2,CCNB1,CDK1,CDK5,CDK5R1,CDK10,CDK11B,CDK12,CDK13,CDK14,CDK15,CDK16,CDK17,CDK18,CDK19,CDK20,CDK3,CDK6,CDK8}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase GSK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK7 subfamily",
"CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Glycogen synthase kinase (GSK) family","GSK subfamily"}

> <pathway_reactome>
{Disease,"Infectious disease","SARS-CoV Infections","SARS-CoV-1 Infection","SARS-CoV-1 Genome Replication and Transcription","Replication of the SARS-CoV-1 genome"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HA79388,DB12686,NSC-800851,NSC800851,PHA-793887,PHA793887,718630-59-2,718630592,UNII-MKS45S912B,UNIIMKS45S912B,MKS45S912B,CHEMBL1230607,"718630-59-2 (free base)","718630592 (free base)","PHA 793887",
C19H31N5O2,cc-404,cc404,MLS006010173,SCHEMBL5110328,CHEBI:91371,DTXSID50222134,BCPP000110,HMS3265M13,HMS3265M14,HMS3265N13,HMS32,T2113,S1487}

> <pdid>
PD003377

> <targets>
{CDK,Apoptosis}

> <classes>
{Cell Cycle,Apoptosis,Cell Cycle/DNA Damage}

> <pubchem_cids>
{46191454}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  1  0            999 V2000
   -0.0041   -2.9953    0.0000 C   0  0
    1.2925   -3.7494    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 C   0  0
    0.0079    7.5003    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  3  2  1  1
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
  9 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 21 25  1  0
 25 18  1  0
 25 26  2  0
 26  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28469

> <plate>
Kinase v5-2

> <well>
M11

> <supplier_cmpd_name>
Roscovitine(CYC202)

> <ctcr_id>
1691

> <supplier_cmpd_id>
S1153

> <smiles>
CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1

> <pd_targets>
{LMNA,CCNE1,CDK2,CCNH,CDK7,MNAT1,CCNB1,CDK1,CCNA1,CCNA2,MAPK1,DYRK1B,GMNN,CLK1,DYRK1A,CDK5,CDK5R1,GSK3-BETA,GSK3A,CCNT1,CDK9,RPS6KA2,CSNK1G2,CCND1,CDK4,CCNE2,MAPK3,CSNK1D,CSNK1A1,CDK6,CDK16,CLK2,CSNK1
E,GSK3B,SMN1,CLK4,CCNB2,CCNB3,CSNK1G3,DYRK2,CSNK1G1,SYN1,THRB,PMP22,PAK4,ALK,TTK,CACNA1C,CACNA1B,SRPK1,HIPK4,CYP2D6,CYP1A2,NFKB1,HIF1A,CHRM1,CYP3A4,CYP2C9,TSHR}

> <pathway_gtopdb>
{"Other nuclear protein",Enzyme,"Unclassified protein","Epigenetic regulator","Other cytosolic protein","Transcription factor","Ion channel",Kinase,Reader,"Nuclear receptor","Voltage-gated ion channel
","Protein Kinase","Methyl-lysine/arginine binding protein","Nuclear hormone receptor subfamily 1","Voltage-gated calcium channel","CMGC protein kinase group","AGC protein kinase group","CK1 protein k
inase group","Tudor domain","Nuclear hormone receptor subfamily 1 group A","STE protein kinase group","TKL protein kinase group","Other protein kinase group","CMGC protein kinase CDK family","CMGC pro
tein kinase MAPK family","CMGC protein kinase DYRK family","CMGC protein kinase CLK family","CMGC protein kinase GSK family","AGC protein kinase RSK family","CK1 protein kinase CK1 family","Nuclear ho
rmone receptor subfamily 1 group A member 2","STE protein kinase STE20 family","TKL protein kinase STKR family","Other protein kinase TTK family","CMGC protein kinase CDC2 subfamily","CMGC protein kin
ase CDK7 subfamily","CMGC protein kinase ERK1","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK9 subfamily","AGC protein kinase RSK subfamily","CMGC 
protein kinase TAIRE subfamily","CK1 protein kinase CK1-g","CMGC protein kinase Dyrk2 subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase SRP
K family","CMGC protein kinase HIPK subfamily","Membrane receptor","Cytochrome P450","Family A G protein-coupled receptor","Cytochrome P450 family 2","Cytochrome P450 family 1","Small molecule recepto
r (family A GPCR)","Cytochrome P450 family 3","Peptide receptor (family A GPCR)","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Monoamine receptor","Cytochrome P450 family 3A","Cytochrome P4
50 family 2C","Glycohormone receptor","Cytochrome P450 2D6","Cytochrome P450 1A1","Acetylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 2C9"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Catalytic receptors","Voltage-gated ion channels","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing
 PKA",PKG,"PKC families","CK1: Casein kinase 1","1A. Thyroid hormone receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","Voltage-gated calcium channels"
,"Cyclin-dependent kinase (CDK) family","Mitogen-activated protein kinases (MAP kinases)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CLK family","RSK family","Case
in kinase 1 (CK1) family","STE20 family","TK: Tyrosine kinase","Other protein kinases","CDK1 subfamily","ERK subfamily","Dyrk1 subfamily","CDK5 subfamily","RSK subfamily","CDK9 subfamily","TAIRE subfa
mily","CDK4 subfamily","Dyrk2 subfamily","CDK7 subfamily","PAKB subfamily","Receptor tyrosine kinases (RTKs)","TTK family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","SRPK family
","HIPK subfamily","Cytochrome P450","G protein-coupled receptors","CYP2 family: drug metabolising subset","CYP1 family","Acetylcholine receptors (muscarinic)","CYP3 family","Glycoprotein hormone rece
ptors"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)","Immune System",Metabolism,Disease,"Metabolism of RNA","Neuronal System","Metabolism of proteins","Developmental Biology",Mitotic,"RNA Polymerase II Tra
nscription","Innate Immune System","Metabolism of lipids","Infectious disease","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of non-coding RNA","Transm
ission across Chemical Synapses","Post-translational protein modification","Nervous system development","M Phase","Generic Transcription Pathway","Toll-like Receptor Cascades","Mitotic G1 phase and G1
/S transition","Sphingolipid metabolism","HIV Infection","Mitotic G2-G2/M phases","Signaling by WNT in cancer","snRNP Assembly","Regulation of mitotic cell cycle","Neurotransmitter release cycle",SUMO
ylation,"EGR2 and SOX10-mediated initiation of Schwann cell myelination","Axon guidance","Presynaptic depolarization and calcium channel opening","Mitotic Metaphase and Anaphase","Transcriptional Regu
lation by TP53","Toll Like Receptor 5 (TLR5) Cascade","G1/S Transition","G0 and Early G1","Sphingolipid de novo biosynthesis","HIV Life Cycle","G2/M Transition","Signaling by AMER1 mutants","APC/C-med
iated degradation of cell cycle proteins","G1 Phase","Dopamine Neurotransmitter Release Cycle","SUMO E3 ligases SUMOylate target proteins","Signaling by ROBO receptors","NCAM signaling for neurite out
-growth","Mitotic Anaphase","Regulation of TP53 Activity","MyD88 cascade initiated on plasma membrane","Activation of the pre-replicative complex","Late Phase of HIV Life Cycle","Centrosome maturation
","Truncations of AMER1 destabilize the destruction complex","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Cyclin D associated events in G1","SUMOylation of intracell
ular receptors","Activation of RAC1","NCAM1 interactions","Nuclear Envelope (NE) Reassembly","Regulation of TP53 Expression and Degradation","MAP kinase activation","Regulation of TP53 Activity throug
h Phosphorylation","Transcription of the HIV genome","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic proteins","Ini
tiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","HIV Transcription Elongation","Loss of Nlp from mitotic centrosom
es","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","CREB phosphorylation","Tat-mediated elongation of the HIV-1 transcript
","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated","Formation of HIV-1 elongation complex containing HIV-1 Tat","Cellular responses to external stimuli","Signal Transducti
on","Biological oxidations","Cytokine Signaling in Immune system","Cellular responses to stress","Signaling by GPCR","Phase I - Functionalization of compounds","Signaling by Interleukins","Cellular re
sponse to hypoxia","GPCR ligand binding","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","Cytochrome P450 - arranged by substrate type","Interleukin-1 family signali
ng","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","Leishmania parasite growth and survival",Xenob
iotics,"Interleukin-1 signaling","Amine ligand-binding receptors","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","CYP2E1 reactions","Aromatic amines ca
n be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammator
y cytokines production"}

> <broad_targets>
{CDK2,CDK9}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{roscovitine,Seliciclib,186692-46-6,186692466,R-Roscovitine,RRoscovitine,(R)-roscovitine,(R)roscovitine,CYC202,CYC-202,"CYC 202","Roscovitine (Seliciclib,CYC202)",2-(R)-(1-Ethyl-2-hydroxyethylamino)-6
-benzylamino-9-isopropylpurine,2(R)(1Ethyl2hydroxyethylamino)6benzylamino9isopropylpurine,UNII-0ES1C2KQ94,UNII0ES1C2KQ94,(R)-2-((6-(Benzylamino)-9-isopropyl,(R)2((6(Benzylamino)9isopropyl,T2095,S1153,
CC-205,"EMD 557360",Roscovitine,Roscovitine(CYC202),557360,ROSCOVITINE}

> <pdid>
PD011113

> <targets>
{CDK,cdk5,cdc2,cdk2}

> <classes>
{}

> <pubchem_cids>
{160355}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
   12.4289  -10.2253    0.0000 C   0  0
   11.1294  -10.9745    0.0000 C   0  0
   11.1290  -12.4745    0.0000 C   0  0
   12.4281  -11.7250    0.0000 C   0  0
    9.8319  -10.2254    0.0000 C   0  0
    9.6751   -8.7336    0.0000 O   0  0
    8.2168   -8.4417    0.0000 C   0  0
    7.6035   -7.0719    0.0000 C   0  0
    6.1107   -6.9172    0.0000 S   0  0
    5.4984   -5.5497    0.0000 C   0  0
    4.0312   -5.2378    0.0000 S   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.2447   -3.1359    0.0000 N   0  0
    6.2484   -4.2507    0.0000 C   0  0
    7.4579   -9.7208    0.0000 N   0  0
    8.4616  -10.8355    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
 12 22  2  0
 22 23  1  0
 23 10  2  0
  7 24  2  0
 24 25  1  0
 25  5  2  0
M  END
> <name>
UTKinase_V5

> <id>
28470

> <plate>
Kinase v5-2

> <well>
M13

> <supplier_cmpd_name>
SNS-032(BMS-387032)

> <ctcr_id>
2475

> <supplier_cmpd_id>
S1145

> <smiles>
CC(C)(C)c1oc(CSc2sc(NC(=O)C3CCNCC3)nc2)nc1

> <pd_targets>
{MAPK6,BRSK2,MAK,HIPK2,CDK1,CIT,CDK9,CCNB1,FLT3,CSNK1E,AURKA,CDKL2,MAP3K7,CCNE1,CDK2,MKNK1,CDK19,CDK8,AURKC,CLK1,CDK7,CLK2,CDK5,CDK3,CDK16,CDK14,DCLK3,DCLK1,STK17A,DYRK1B,MAPK4,CCNH,CSNK1D,DYRK2,DYRK1
A,MYLK3,CCND1,CDK4,IRAK3,CCNE2,PRKD1,CDKL5,HIPK3,RIOK2,PRKD3,GSK3A,MELK,MAPK10,CDK11A,CLK4,DCLK2,STK36,GAK,CDK17,PAK3,CDK15,HIPK1,PHKG2,MKNK2,MYLK2,COQ8B,TAOK3,NUAK2,MAPK15,PRKD2,TGFBR2,PHKG1,MYLK4,PR
KAA1,BRAF,CASK,TAOK2,MYLK,CSNK1A1,CCND2,CCND3,MAPK7,GSK3B,MAST1,TAOK1,RPS6KA5,CDK11B,CCNB2,CCNB3,CDKL3,CCNT1,ULK1,CILK1,CDK13,FLT1,CDK18,CCNA2,MNAT1,CDK5R1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CAMK protein kinase group","AGC protein kinase group","TK protein kinase group","CK1 protein kinase group","Other protein kinase group","TK
L protein kinase group","Atypical protein kinase group","STE protein kinase group","CMGC protein kinase MAPK family","CAMK protein kinase CAMK1 family","CMGC protein kinase RCK family","CMGC protein k
inase DYRK family","CMGC protein kinase CDK family","AGC protein kinase DMPK family","Tyrosine protein kinase PDGFR family","CK1 protein kinase CK1 family","Other protein kinase AUR family","CMGC prot
ein kinase CDKL family","TKL protein kinase MLK family","CAMK protein kinase MAPKAPK family","CMGC protein kinase CLK family","CAMK protein kinase DCAMK1 family","CAMK protein kinase DAPK family","CAM
K protein kinase MLCK family","TKL protein kinase IRAK family","CAMK protein kinase PKD family","Atypical protein kinase RIO family","CMGC protein kinase GSK family","Other protein kinase ULK family",
"Other protein kinase NAK family","STE protein kinase STE20 family","CAMK protein kinase PHk family","Atypical protein kinase ABC1 family","TKL protein kinase STKR family","TKL protein kinase RAF fami
ly","AGC protein kinase MAST family","AGC protein kinase RSK family","Tyrosine protein kinase VEGFR family","CMGC protein kinase ERK3","CAMK protein kinase BRSK subfamily","CMGC protein kinase MAK","C
MGC protein kinase HIPK subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase CRIK subfamily","CMGC protein kinase CDK9 subfamily","TKL protein kinase TAK1 subfamily","CAMK protein kinas
e MNK subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase TAIRE subfamily","CMGC protein kinase PFTAIRE","CMG
C protein kinase Dyrk1 subfamily","CMGC protein kinase Dyrk2 subfamily","Atypical protein kinase RIO2 subfamily","CAMK protein kinase MELK subfamily","CMGC protein kinase JNK subfamily","CMGC protein 
kinase PITSLRE subfamily","CMGC protein kinase PCTAIRE","STE protein kinase PAKA subfamily","Atypical protein kinase ABC1-A subfamily","STE protein kinase TAO subfamily","CAMK protein kinase NuaK subf
amily","TKL protein kinase STKR Type 2 subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase ERK5","AGC protein kinase MSK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC fami
lies","Receptor kinases","CK1: Casein kinase 1",Atypical,"STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Mitogen-activated protein kinases (MAP kinases)","CAMK-like (CAMKL) famil
y","RCK family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Cyclin-dependent kinase (CDK) family","DMPK family","TK: Tyrosine kinase","Casein kinase 1 (CK1) family"
,"Other protein kinases","Cyclin-dependent kinase-like (CDKL) family","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","CLK family","DCAMKL family","Death-associated kinase
 (DAPK) family","Myosin Light Chain Kinase (MLCK) family","Protein kinase D (PKD) family","RIO family","Glycogen synthase kinase (GSK) family","STE20 family","Phosphorylase kinase (PHK) family","ABC1 
family","CASK family","MAST family","RSK family","ERK subfamily","BRSK subfamily","HIPK subfamily","CDK1 subfamily","Other DMPK family kinases","CDK9 subfamily","Receptor tyrosine kinases (RTKs)","Aur
ora kinase (Aur) family","Mixed Lineage Kinase (MLK) family","MKN subfamily","CDK8 subfamily","CDK7 subfamily","CDK5 subfamily","TAIRE subfamily","Dyrk1 subfamily","Dyrk2 subfamily","Interleukin-1 rec
eptor-associated kinase (IRAK) family","CDK4 subfamily","RIO2 subfamily","GSK subfamily","MELK subfamily","JNK subfamily","PITSLRE subfamily","Unc-51-like kinase (ULK) family","Numb-associated kinase 
(NAK) family","PAKA subfamily","ABC1-B subfamily","TAO subfamily","NuaK subfamily","Erk7 subfamily","Receptor serine/threonine kinase (RSTK) family","AMPK subfamily","RAF family","MSK subfamily","CRK7
 subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","TAK1 subfamily","Type II receptor serine/threonine kinases","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family
"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Cell Cycle",Disease,"Immune System",Metabolism,"Metabolism of RNA","Vesicle-mediated transport","Developmental Biology","Neuronal System",Auto
phagy,"MAPK family signaling cascades","RNA Polymerase II Transcription",Mitotic,"Signaling by Rho GTPases","Infectious disease","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Metabo
lism of lipids","Diseases of signal transduction by growth factor receptors and second messengers","rRNA processing","Membrane Trafficking","Nervous system development","Metabolism of carbohydrates","
Transmission across Chemical Synapses",Macroautophagy,"MAPK6/MAPK4 signaling","Generic Transcription Pathway","Regulation of mitotic cell cycle","RHO GTPase Effectors","HIV Infection","Signaling by In
sulin receptor","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Signaling by FGFR","Regulation of lipid metabolism by PPARalpha","Signaling by NOTCH1 in Cancer","Mitotic G1 phase and G1/S tran
sition","Sphingolipid metabolism","rRNA processing in the nucleus and cytosol","SARS-CoV Infections","trans-Golgi Network Vesicle Budding","Axon guidance","Glycogen metabolism","Signaling by TGF-beta 
Receptor Complex in Cancer","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by WNT in cancer","M Phase","Selective autophagy","Signaling by VEGF","Tra
nscriptional Regulation by TP53","APC/C-mediated degradation of cell cycle proteins","RHO GTPases activate CIT","HIV Life Cycle","Insulin receptor signalling cascade","G2/M Transition","Toll Like Rece
ptor 4 (TLR4) Cascade","Signaling by FGFR4","PPARA activates gene expression","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","G0 and Early G1","Toll Like Receptor 2 (TLR2) Cascade","Sphingolip
id de novo biosynthesis","G1 Phase","Major pathway of rRNA processing in the nucleolus and cytosol","SARS-CoV-1 Infection","Toll Like Receptor 5 (TLR5) Cascade","Golgi Associated Vesicle Biogenesis","
EPH-Ephrin signaling","Glycogen breakdown (glycogenolysis)","Loss of Function of SMAD2/3 in Cancer","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","RHO GTPases acti
vate PAKs","Signaling by AMER1 mutants","Mitotic Metaphase and Anaphase",Mitophagy,"VEGF ligand-receptor interactions","Regulation of TP53 Activity","Activation of APC/C and APC/C:Cdc20 mediated degra
dation of mitotic proteins","Late Phase of HIV Life Cycle","IRS-mediated signalling","Centrosome maturation","MyD88-independent TLR4 cascade","Negative regulation of FGFR4 signaling","Constitutive Sig
naling by NOTCH1 HD+PEST Domain Mutants","Toll Like Receptor TLR6:TLR2 Cascade","Cyclin D associated events in G1","SARS-CoV-1 Genome Replication and Transcription","MyD88 cascade initiated on plasma 
membrane","Ephrin signaling","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Signalling to ERKs","Assembly and cell surface presentation of NMDA receptors","Truncations of AMER1 destabilize the des
truction complex","Mitotic Anaphase","Receptor Mediated Mitophagy","TP53 Regulates Transcription of DNA Repair Genes","VEGF binds to VEGFR leading to receptor dimerization","Regulation of TP53 Activit
y through Phosphorylation","APC/C:Cdc20 mediated degradation of mitotic proteins","Transcription of the HIV genome","PI3K Cascade","Loss of proteins required for interphase microtubule organization fr
om the centrosome","TRIF(TICAM1)-mediated TLR4 signaling","Spry regulation of FGF signaling","Regulation of TP53 Expression and Degradation","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Re
plication of the SARS-CoV-1 genome","MAP kinase activation","Recruitment of mitotic centrosome proteins and complexes","Prolonged ERK activation events","Separation of Sister Chromatids","APC:Cdc20 me
diated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","HIV Transcription Elongation","Loss of Nlp from mitotic centrosomes","TRAF6-mediated induction of TAK1 com
plex within TLR4 complex","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat
-mediated elongation of the HIV-1 transcript","Activation of the AP-1 family of transcription factors","ERK/MAPK targets","CREB phosphorylation","Formation of HIV-1 elongation complex containing HIV-1
 Tat","ERKs are inactivated"}

> <broad_targets>
{CDK2,CDK7,CDK9}

> <broad_moa>
{"CDK inhibitor","cell cycle inhibitor","MCL1 inhibitor"}

> <synonyms>
{MS38703,SNS-032,SNS032,345627-80-7,345627807,BMS-387032,BMS387032,"SNS 032","BMS 387032","SNS-032 (BMS-387032)","SNS032 (BMS387032)",UNII-9979I93686,UNII9979I93686,"SNS-032 (hydrochloride)","SNS032 (
hydrochloride)",CHEMBL296468,C17H24N4O2S2,"345627-80-7 (free base)","345627807 (free base)",9979I93686,BMS-387072,BMS387072,Kinome_3820,Kinome3820,Kinome-3820,"Kinome 3820",PubChem16670,Tube004,c,T604
9,S1145,SNS-032(BMS-387032)}

> <pdid>
PD003662

> <targets>
{CDK,Apoptosis}

> <classes>
{Cell Cycle,Apoptosis,Cell Cycle/DNA Damage}

> <pubchem_cids>
{3025986}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  1  0            999 V2000
   13.1886   -3.6010    0.0000 Cl  0  0
    4.6388   -8.1760    0.0000 N   0  0
    3.2151   -7.7040    0.0000 C   0  0
    2.0947   -8.7014    0.0000 O   0  0
    2.9122   -6.2341    0.0000 N   0  0
    4.0312   -5.2378    0.0000 C   0  0
    5.4984   -5.5497    0.0000 C   0  0
    6.2484   -4.2507    0.0000 C   0  0
    5.2447   -3.1359    0.0000 S   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    7.7410   -4.0938    0.0000 C   0  0
    8.7076   -5.2343    0.0000 C   0  0
   10.1833   -4.9657    0.0000 C   0  0
   10.6886   -3.5534    0.0000 C   0  0
    9.7181   -2.4097    0.0000 C   0  0
   10.2234   -0.9973    0.0000 F   0  0
    8.2423   -2.6783    0.0000 C   0  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10  6  2  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 14 13  1  6
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
  8 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 26 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28471

> <plate>
Kinase v5-2

> <well>
M15

> <supplier_cmpd_name>
AZD7762

> <ctcr_id>
7726

> <supplier_cmpd_id>
S1532

> <smiles>
Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)c3cccc(F)c3

> <pd_targets>
{CHEK1,CHEK2,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","CAMK protein kinase group","Voltage-gated potassium channel","CAMK protein kinase CAMK1 family","CAMK pr
otein kinase RAD53 family","CAMK protein kinase CHK1 subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels","Kinases (EC 2.7.x.x)","Voltage-gated ion channels","CAMK: Calcium/calmodulin-dependent protein kinases","Potassium channels","CAMK-like (CAMKL) family","Voltage-gated potassiu
m channels","CHK1 subfamily"}

> <pathway_reactome>
{"DNA Repair","Gene expression (Transcription)","Muscle contraction","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Cardiac conduction","Homology Directed Repair","Generic Transcr
iption Pathway","Phase 3 - rapid repolarisation","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Transcriptional Regulation by TP53","HDR through Homologous Recombinatio
n (HRR)","Regulation of TP53 Activity","Homologous DNA Pairing and Strand Exchange","Regulation of TP53 Expression and Degradation","Presynaptic phase of homologous DNA pairing and strand exchange","R
egulation of TP53 Degradation"}

> <broad_targets>
{CHEK1,CHEK2}

> <broad_moa>
{"CHK inhibitor"}

> <synonyms>
{"AZD 7762 hydrochloride","AZD7762 HCl",1246094-78-9,1246094789,"1246094-78-9 (HCl)","1246094789 (HCl)",C17H19FN4O2S,MLS006010750,SCHEMBL19457662,BCP25387,1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluor
ophenyl)thiophen-3-yl)urea,1(2((S)piperidin3ylcarbamoyl)5(3fluorophenyl)thiophen3yl)urea,AKOS024458535,SMR004701703,AZD-77,AZD77,SY-AZD7762,AZD7762}

> <pdid>
PD003297

> <targets>
{CHK}

> <classes>
{}

> <pubchem_cids>
{56972142}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 46  0  0  0  0            999 V2000
    2.6098   -2.9775    0.0000 C   0  0
    1.3149   -3.7347    0.0000 C   0  0
    0.0106   -2.9924    0.0000 N   0  0
   -1.2854   -3.7477    0.0000 C   0  0
   -2.5875   -3.0031    0.0000 C   0  0
   -2.5937   -1.5031    0.0000 N   0  0
   -1.2977   -0.7477    0.0000 C   0  0
    0.0044   -1.4924    0.0000 C   0  0
   -3.8950   -0.7554    0.0000 C   0  0
   -5.1922   -1.5084    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -7.7985    2.9932    0.0000 C   0  0
   -9.0967    3.7462    0.0000 N   0  0
   -9.0947    5.2471    0.0000 C   0  0
  -10.3911    6.0016    0.0000 N   0  0
  -10.3859    7.5016    0.0000 C   0  0
   -9.0843    8.2471    0.0000 C   0  0
   -9.0792    9.7471    0.0000 F   0  0
   -7.7879    7.4927    0.0000 C   0  0
   -6.4840    8.2360    0.0000 N   0  0
   -5.1879    7.4792    0.0000 C   0  0
   -3.8837    8.2202    0.0000 C   0  0
   -2.5898    7.4613    0.0000 C   0  0
   -2.6002    5.9613    0.0000 C   0  0
   -3.9043    5.2203    0.0000 C   0  0
   -5.1982    5.9792    0.0000 C   0  0
   -1.3072    5.1993    0.0000 C   0  0
   -0.0017    5.9381    0.0000 O   0  0
   -1.3197    3.6985    0.0000 N   0  0
   -0.0267    2.9365    0.0000 C   0  0
    1.2776    3.6775    0.0000 C   0  0
    2.5714    2.9185    0.0000 C   0  0
    2.5611    1.4186    0.0000 C   0  0
    1.2569    0.6776    0.0000 C   0  0
   -0.0369    1.4365    0.0000 C   0  0
   -1.3411    0.6955    0.0000 Cl  0  0
   -7.7930    5.9927    0.0000 N   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  6  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 27 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 37  1  0
 37 38  2  0
 38 33  1  0
 38 39  1  0
 22 40  2  0
 40 17  1  0
 15 41  1  0
 41 42  2  0
 42 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28472

> <plate>
Kinase v5-2

> <well>
M17

> <supplier_cmpd_name>
Aurora A Inhibitor I

> <ctcr_id>
2082

> <supplier_cmpd_id>
S1451

> <smiles>
CCN1CCN(CC1)C(=O)Cc2ccc(Nc3ncc(F)c(Nc4ccc(cc4)C(=O)Nc5ccccc5Cl)n3)cc2

> <pd_targets>
{AURKA,AURKB,AURKC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Aurora kinase (Aur) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","M Phase","Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase
","Regulation of TP53 Activity","Mitotic Anaphase","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids"}

> <broad_targets>
{AURKA}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{"Aurora A Inhibitor I",1158838-45-9,1158838459,"1158838 45 9","2,4-Bisanilinopyrimidine, 10","2,4Bisanilinopyrimidine, 10","2,4 Bisanilinopyrimidine, 10",Aurora-A-inhibitor-I,AuroraAinhibitorI,"Auror
a A inhibitor I",TCS7010,"TC-S 7010","TCS 7010",T,S1451}

> <pdid>
PD011189

> <targets>
{Aurora,"Aurora Kinase"}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{44139710}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 40  0  0  0  0            999 V2000
    6.4894   -3.7601    0.0000 C   0  0
    6.4889   -5.2601    0.0000 C   0  0
    5.1894   -6.0109    0.0000 N   0  0
    5.1873   -7.5117    0.0000 C   0  0
    6.4855   -8.2648    0.0000 C   0  0
    6.4833   -9.7648    0.0000 O   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.6012    3.0008    0.0000 N   0  0
   -3.9020    3.7494    0.0000 C   0  0
   -4.0450    5.2297    0.0000 C   0  0
   -5.5133    5.5365    0.0000 C   0  0
   -6.1303    6.9018    0.0000 C   0  0
   -7.6237    7.0513    0.0000 C   0  0
   -8.4990    5.8332    0.0000 O   0  0
   -8.2418    8.4190    0.0000 N   0  0
   -9.7351    8.5685    0.0000 C   0  0
  -10.3548    9.9345    0.0000 C   0  0
  -11.8477   10.0809    0.0000 C   0  0
  -12.7209    8.8613    0.0000 C   0  0
  -12.1013    7.4953    0.0000 C   0  0
  -12.9745    6.2756    0.0000 F   0  0
  -10.6084    7.3488    0.0000 C   0  0
   -6.2588    4.2348    0.0000 N   0  0
   -5.2512    3.1236    0.0000 N   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  3  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 28 30  2  0
 30 24  1  0
 19 31  1  0
 31 32  1  0
 32 17  2  0
 15 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 14  1  0
 36 37  2  0
 37 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28473

> <plate>
Kinase v5-2

> <well>
M19

> <supplier_cmpd_name>
AZD1152-HQPA(Barasertib)

> <ctcr_id>
5723

> <supplier_cmpd_id>
S1147

> <smiles>
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1

> <pd_targets>
{MAP2K2,ABL1,KIT,RET,FLT1,CHEK2,ERBB4,CDK13,EGFR,LYN,CDK16,KDR,AURKA,FLT3,MAP3K20,CDK11B,MUSK,IRAK3,SRMS,STK36,AURKB,AURKC,AXL,BLK,ERBB2,LTK,PAK1,LCK,PDGFRB,RPS6KB1,CDK11A,PDGFRA,TEK,CIT,AAK1,YES1,MAP
3K7,BTK,TNIK,PLK4,HCK,RIPK2,DSTYK,CSK,FLT4,MET,MKNK2,TTK,CSF1R,CDK7,MAP2K1,ANKK1,STK10,CDKL2,HIPK3,EIF2AK1,HIPK2,TIE1,MAP4K4,MAP4K5,MAP3K19,DDR1,HIPK4,TUBA1A,EPHB6,MAP4K2,MAP2K5,CSNK1D,DDR2,MST1R,ZAP7
0}

> <pathway_gtopdb>
{Enzyme,"Structural protein","Unclassified protein",Kinase,"Protein Kinase","STE protein kinase group","TK protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Other protein 
kinase group","TKL protein kinase group","AGC protein kinase group","CK1 protein kinase group","STE protein kinase STE7 family","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR fami
ly","Tyrosine protein kinase Ret family","Tyrosine protein kinase VEGFR family","CAMK protein kinase RAD53 family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Src family","CMGC prot
ein kinase CDK family","Other protein kinase AUR family","TKL protein kinase MLK family","Tyrosine protein kinase Musk family","TKL protein kinase IRAK family","Other protein kinase ULK family","Tyros
ine protein kinase Axl family","Tyrosine protein kinase Alk family","STE protein kinase STE20 family","AGC protein kinase RSK family","Tyrosine protein kinase Tie family","AGC protein kinase DMPK fami
ly","Other protein kinase NAK family","Tyrosine protein kinase Tec family","Other protein kinase PLK family","TKL protein kinase RIPK family","Tyrosine protein kinase Csk family","Tyrosine protein kin
ase Met family","CAMK protein kinase MAPKAPK family","Other protein kinase TTK family","CMGC protein kinase CDKL family","CMGC protein kinase DYRK family","Other protein kinase PEK family","STE protei
n kinase STE11 family","Tyrosine protein kinase DDR family","CK1 protein kinase CK1 family","Tyrosine protein kinase Syk family","CMGC protein kinase TAIRE subfamily","TKL protein kinase MLK subfamily
","CMGC protein kinase PITSLRE subfamily","Tyrosine protein kinase Srm","STE protein kinase PAKA subfamily","AGC protein kinase p70 subfamily","AGC protein kinase CRIK subfamily","TKL protein kinase T
AK1 subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase SLK subfamily","CMGC protein kinase HIPK subfamily","Othe
r protein kinase HRI","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets","Kinases (EC 2.7.x.x)","Catalytic receptors",Tubulins,"STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","CAMK: Calcium/
calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase 1","STE7 family","TK: Tyrosine kinase","CAMK-like (CA
MKL) family","Cyclin-dependent kinase (CDK) family","Other protein kinases","TKL: Tyrosine kinase-like","STE20 family","RSK family","DMPK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Cycl
in-dependent kinase-like (CDKL) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Casein kinase 1 (CK1) family","Non-receptor tyrosine kinases (nRTKs)","Receptor 
tyrosine kinases (RTKs)","CHK1 subfamily","CRK7 subfamily","TAIRE subfamily","Aurora kinase (Aur) family","Mixed Lineage Kinase (MLK) family","PITSLRE subfamily","Interleukin-1 receptor-associated kin
ase (IRAK) family","Unc-51-like kinase (ULK) family","PAKA subfamily","p70 subfamily","Other DMPK family kinases","NAK family","MSN subfamily","Polo-like kinase (PLK) family","Receptor interacting pro
tein kinase (RIPK) family","Other-unique family","MKN subfamily","TTK family","CDK7 subfamily","SLK subfamily","HIPK subfamily","PEK family","KHS subfamily","STE20 subfamily","Abl family","Type III RT
Ks: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIV RTKs: RET","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family",
"Src family","MLK subfamily","Type IX RTKs: MuSK","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XII RTKs: TIE fa
mily of angiopoietin receptors","TAK1 subfamily","Tec family","Csk family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Other PEK family kinases","Type XVI RTKs: DDR (collagen recept
or) family","Type XIII RTKs: Ephrin receptor family","Syk family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Developmental Biology","Gene expression (Transcription)","Neuronal System","Cell Cycle","Extracellular matrix organization","Immune System","Vesicle-mediated transport"
,"Cellular responses to external stimuli","Signaling by Receptor Tyrosine Kinases","Infectious disease","Diseases of signal transduction by growth factor receptors and second messengers","Nervous syst
em development","RNA Polymerase II Transcription","Transmission across Chemical Synapses","Signaling by GPCR",Mitotic,"ECM proteoglycans","Innate Immune System","Signaling by Non-Receptor Tyrosine Kin
ases","Intracellular signaling by second messengers","MTOR signalling","MAPK family signaling cascades","Signaling by Rho GTPases","Membrane Trafficking","Cellular responses to stress","Non-integrin m
embrane-ECM interactions","Adaptive Immune System","Signaling by NTRKs","Leishmania infection","Signaling by KIT in disease","Axon guidance","Signaling by VEGF","Generic Transcription Pathway","Neurot
ransmitter receptors and postsynaptic signal transmission","GPCR downstream signalling","Signaling by Insulin receptor","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Signaling by PTK6","M Ph
ase","HIV Infection","PIP3 activates AKT signaling","mTORC1-mediated signalling","Signaling by PDGFR in disease","MAPK1/MAPK3 signaling","RHO GTPase Effectors","Clathrin-mediated endocytosis","Cellula
r Senescence","Oncogenic MAPK signaling","Neutrophil degranulation","Response of EIF2AK1 (HRI) to heme deficiency","Signaling by MST1","TCR signaling","Signaling by NTRK1 (TRKA)","Parasite infection",
"Drug resistance of KIT mutants","RET signaling","VEGF ligand-receptor interactions","Transcriptional Regulation by TP53","Activation of NMDA receptors and postsynaptic events","G alpha (q) signalling
 events","Leishmania parasite growth and survival","VEGFA-VEGFR2 Pathway","Insulin receptor signalling cascade","G2/M Transition","Toll Like Receptor 2 (TLR2) Cascade","PTK6 Down-Regulation","Mitotic 
Metaphase and Anaphase","Transcriptional regulation by RUNX1","Semaphorin interactions","EPH-Ephrin signaling","Host Interactions of HIV factors","Negative regulation of the PI3K/AKT network","Drug re
sistance of PDGFR mutants","RAF/MAP kinase cascade","RHO GTPases activate CIT","Cargo recognition for clathrin-mediated endocytosis","Toll Like Receptor 4 (TLR4) Cascade","Oxidative Stress Induced Sen
escence","Toll Like Receptor 5 (TLR5) Cascade","Signaling by RAS mutants","Transcriptional Regulation by VENTX","HIV Life Cycle","Generation of second messenger molecules","Signalling to ERKs","Leishm
ania phagocytosis","Dasatinib-resistant KIT mutants","VEGF binds to VEGFR leading to receptor dimerization","Regulation of TP53 Activity","Post NMDA receptor activation events","TP53 Regulates Transcr
iption of DNA Repair Genes","Gastrin-CREB signalling pathway via PKC and MAPK","Anti-inflammatory response favouring Leishmania parasite infection","VEGFR2 mediated cell proliferation","IRS-mediated s
ignalling","Centrosome maturation","Toll Like Receptor TLR6:TLR2 Cascade","Mitotic Anaphase","RUNX1 regulates transcription of genes involved in BCR signaling","Sema4D in semaphorin signaling","EPHB-m
ediated forward signaling","The role of Nef in HIV-1 replication and disease pathogenesis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Imatinib-resistant PDGFR mutants","MyD88-independent TLR4 c
ascade","MyD88 cascade initiated on plasma membrane","Signaling downstream of RAS mutants","Late Phase of HIV Life Cycle","Signalling to ERK5","Prolonged ERK activation events","FCGR3A-mediated phagoc
ytosis","Regulation of TP53 Expression and Degradation","Long-term potentiation","EGFR Transactivation by Gastrin","FCGR3A-mediated IL10 synthesis","Regulation of TP53 Activity through Phosphorylation
","PI3K Cascade","Recruitment of mitotic centrosome proteins and complexes","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Separation of Sister Chromatids","Sema4D induced cell migration and
 growth-cone collapse","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","TRIF(TICAM1)-mediated TLR4 signaling","Loss of proteins required for interphase
 microtubule organization from the centrosome","Nef and signal transduction","MAP kinase activation","Sema4D mediated inhibition of cell attachment and migration","Transcription of the HIV genome","Fr
s2-mediated activation","Regulation of TP53 Degradation","Nef Mediated CD4 Down-regulation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Loss of Nlp from mitotic centrosomes","activ
ated TAK1 mediates p38 MAPK activation","HIV Transcription Elongation","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NSC799356,s1147,ZINC16697102,AKOS025404840,BDBM50466808,MFCD10687152,NSC757444,722544-51-6,722544516,AZD1152-HQPA,AZD1152HQPA,AZD-1152HQPA,"Barasertib (AZD1152-HQPA)","Barasertib (AZD1152HQPA)",baras
ertib-hQPA,barasertibhQPA,UNII-29P8LWS24N,UNII29P8LWS24N,AZD-1152-HQPA,"INH 34","AZD1152 HPQA",29P8LWS24N,CHEMBL215152,INH-34,INH34,Bar,T2602,S1147,Barasertib,barasertib,AZD1152-HQPA(Barasertib)}

> <pdid>
PD003227

> <targets>
{Aurora B,Aurora,Aurora Kinase,Apoptosis}

> <classes>
{Cell Cycle,Apoptosis,Cell Cycle/DNA Damage,Epigenetics}

> <pubchem_cids>
{16007391}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
   10.2397    1.6981    0.0000 C   0  0
    9.5915    0.3454    0.0000 N   0  0
   10.4393   -0.8920    0.0000 C   0  0
    8.0952    0.2294    0.0000 C   0  0
    7.4450   -1.1224    0.0000 C   0  0
    5.9493   -1.2353    0.0000 C   0  0
    5.1072    0.0000    0.0000 C   0  0
    5.7538    1.3554    0.0000 C   0  0
    7.2495    1.4683    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Cl  0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 N   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 N   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
    0.0102   -7.5017    0.0000 C   0  0
    1.3123   -8.2482    0.0000 C   0  0
    2.6088   -7.4939    0.0000 O   0  0
    1.3177   -9.7490    0.0000 N   0  0
    2.6197  -10.4955    0.0000 C   0  0
    2.7651  -11.9756    0.0000 S   0  0
    4.2339  -12.2800    0.0000 C   0  0
    4.9773  -10.9772    0.0000 C   0  0
    3.9680   -9.8676    0.0000 N   0  0
    2.7248    1.2135    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 12  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 19  1  0
 22 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 29  2  0
 13 34  1  0
 34 10  2  0
M  END
> <name>
UTKinase_V5

> <id>
28474

> <plate>
Kinase v5-2

> <well>
M21

> <supplier_cmpd_name>
CCT129202

> <ctcr_id>
1527

> <supplier_cmpd_id>
S1519

> <smiles>
CN(C)c1ccc(cc1)c2[nH]c3c(ncc(Cl)c3N4CCN(CC4)CC(=O)Nc5sccn5)n2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{AURKA,AURKB,AURKC}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{CCT129202,942947-93-5,942947935,CCT-129202,UNII-8N349V9Q27,UNII8N349V9Q27,CHEMBL392525,8N349V9Q27,"CCT 129202",cc-472,cc472,MLS006011038,SCHEMBL209571,DTXSID50241406,BCPP000297,HMS3654B20,BCP02164,AB
P000123,BDBM50224734,s1519,ZINC28824607,AKOS030230261,BCP9000497,CCG-269670,CCG269670,CS-02,CS02,S1519}

> <pdid>

> <targets>
{Aurora,"Aurora Kinase"}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{16202152}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -3.9069    5.2492    0.0000 N   0  0
   -5.2089    5.9957    0.0000 C   0  0
   -5.3543    7.4758    0.0000 C   0  0
   -6.8231    7.7802    0.0000 C   0  0
   -7.4401    9.1474    0.0000 C   0  0
   -7.5665    6.4774    0.0000 N   0  0
   -6.5572    5.3678    0.0000 N   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -6.4939    0.7411    0.0000 C   0  0
   -6.4894   -0.7597    0.0000 C   0  0
   -7.7864   -1.5148    0.0000 C   0  0
   -7.7841   -3.0149    0.0000 C   0  0
   -9.0819   -3.7670    0.0000 C   0  0
  -10.3821   -3.0191    0.0000 C   0  0
  -10.3846   -1.5191    0.0000 C   0  0
   -9.0867   -0.7670    0.0000 C   0  0
   -3.8967    0.7484    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 17 12  2  0
 10 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 19 28  2  0
 28  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28475

> <plate>
Kinase v5-2

> <well>
O03

> <supplier_cmpd_name>
ENMD-2076

> <ctcr_id>
7085

> <supplier_cmpd_id>
S1181

> <smiles>
CN1CCN(CC1)c2cc(Nc3cc(C)[nH]n3)nc(\C=C\c4ccccc4)n2

> <pd_targets>
{RET,CSF1R,AURKB,SRC,FLT3,PTK2,ABL1,KDR,AURKA,PDGFRA,KIT,FGFR1,FGFR3,MAP2K1,TBK1,PLK4,MAP4K4,LRRK2,LIMK1,CHEK1,NTRK1,MINK1,IRAK1,PRKCG,BTK,NTRK3,PRKAA1,RPS6KB1,HIPK2,DYRK1B,ROS1,PAK4,PTK6,NTRK2,FLT1,I
NSR,EPHA2,IKBKE,MAP2K2,MAP4K2,SLK,MAP4K5,STK3,GSK3A,GSK3B,FER,SYK,MST1R,TNK2,PDGFRB,TAOK1,TYK2,DAPK3,BLK,PAK1,JAK2,FRK,LCK,CLK4,CDK7,PDPK1,BRSK1,RPS6KA3,STK17A,MARK3,ITK,ACVR1,JAK3,HIPK4,IRAK4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","STE protein kinase group","TKL protein kinase group","CAMK protein kinase group","AGC protein kinase group","CMG
C protein kinase group","Tyrosine protein kinase Ret family","Tyrosine protein kinase PDGFR family","Other protein kinase AUR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Fak 
family","Tyrosine protein kinase Abl family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase FGFR family","STE protein kinase STE7 family","Other protein kinase IKK family","Other prot
ein kinase PLK family","STE protein kinase STE20 family","TKL protein kinase LRRK family","TKL protein kinase LISK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Trk family","TKL 
protein kinase IRAK family","AGC protein kinase PKC family","Tyrosine protein kinase Tec family","AGC protein kinase RSK family","CMGC protein kinase DYRK family","Tyrosine protein kinase Sev family",
"Tyrosine protein kinase InsR family","Tyrosine protein kinase Eph family","CMGC protein kinase GSK family","Tyrosine protein kinase Fer family","Tyrosine protein kinase Syk family","Tyrosine protein 
kinase Met family","Tyrosine protein kinase Ack family","Tyrosine protein kinase JakA family","CAMK protein kinase DAPK family","CMGC protein kinase CLK family","CMGC protein kinase CDK family","AGC p
rotein kinase PDK1 subfamily","TKL protein kinase STKR family","STE protein kinase MSN subfamily","TKL protein kinase LIMK subfamily","CAMK protein kinase CHK1 subfamily","AGC protein kinase PKC alpha
 subfamily","CAMK protein kinase AMPK subfamily","AGC protein kinase p70 subfamily","CMGC protein kinase HIPK subfamily","CMGC protein kinase Dyrk1 subfamily","STE protein kinase PAKB subfamily","STE 
protein kinase KHS subfamily","STE protein kinase SLK subfamily","STE protein kinase MST subfamily","STE protein kinase TAO subfamily","STE protein kinase PAKA subfamily","CMGC protein kinase CDK7 sub
family","CAMK protein kinase BRSK subfamily","AGC protein kinase RSK subfamily","CAMK protein kinase MARK subfamily","TKL protein kinase STKR1"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kina
ses","AGC: Containing PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Other protein kinases","STE7 family","STE20 family","TKL: Tyrosine kinase-like","CA
MK-like (CAMKL) family","Protein kinase C (PKC) family","RSK family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Glycogen synthase kinase (GSK) family","Death-assoc
iated kinase (DAPK) family","CLK family","Cyclin-dependent kinase (CDK) family","PDK1 family","Receptor tyrosine kinases (RTKs)","Aurora kinase (Aur) family","Non-receptor tyrosine kinases (nRTKs)","I
KK family","Polo-like kinase (PLK) family","MSN subfamily","Leucine-rich repeat kinase (LRRK) family","LIM domain kinase (LISK) family","CHK1 subfamily","Interleukin-1 receptor-associated kinase (IRAK
) family","Alpha subfamily","AMPK subfamily","p70 subfamily","HIPK subfamily","Dyrk1 subfamily","PAKB subfamily","KHS subfamily","SLK subfamily","MST subfamily","GSK subfamily","TAO subfamily","PAKA s
ubfamily","CDK7 subfamily","BRSK subfamily","RSK subfamily","MARK subfamily","Receptor serine/threonine kinase (RSTK) family","Type XIV RTKs: RET","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family
","Src family","Fak family","Abl family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","LIMK subfamily","Type 
VII RTKs: Neurotrophin receptor/Trk family","Tec family","Type XVII RTKs: ROS receptors","Type II RTKs: Insulin receptor family","Type XIII RTKs: Ephrin receptor family","Fer family","Syk family","Typ
e X RTKs: HGF (hepatocyte growth factor) receptor family","Ack family","Janus kinase (JakA) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{"Developmental Biology","Gene expression (Transcription)","Cell Cycle","Signal Transduction",Disease,"Immune System","Cellular responses to external stimuli","DNA Repair","Neuronal System","Programme
d Cell Death","Nervous system development","RNA Polymerase II Transcription",Mitotic,"Signaling by Receptor Tyrosine Kinases","Infectious disease","Diseases of signal transduction by growth factor rec
eptors and second messengers","Innate Immune System","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases","DNA Double-Strand Break Repair","Transmission across Chemical Synapses
","MTOR signalling","Intracellular signaling by second messengers","Signaling by Hippo","Cytokine Signaling in Immune system",Apoptosis,"Adaptive Immune System","Axon guidance","Generic Transcription 
Pathway","M Phase","Signaling by NTRKs","Signaling by Insulin receptor","Leishmania infection","Signaling by VEGF","Signaling by PDGFR in disease","Signaling by KIT in disease","Signaling by FGFR in d
isease","Toll-like Receptor Cascades","Mitotic G2-G2/M phases","Cellular Senescence","Signaling by PTK6","Homology Directed Repair","Neurotransmitter receptors and postsynaptic signal transmission","m
TORC1-mediated signalling","Mitotic G1 phase and G1/S transition","PIP3 activates AKT signaling","SARS-CoV Infections","Signaling by SCF-KIT","Signaling by MST1","Interferon Signaling","Caspase activa
tion via extrinsic apoptotic signalling pathway","HIV Infection","Oncogenic MAPK signaling","TCR signaling","Signaling by Interleukins","RET signaling","Transcriptional Regulation by VENTX","Mitotic M
etaphase and Anaphase","Signaling by NTRK1 (TRKA)","Insulin receptor signalling cascade","Parasite infection","VEGFA-VEGFR2 Pathway","Transcriptional Regulation by TP53","Drug resistance of PDGFR muta
nts","Drug resistance of KIT mutants","Signaling by FGFR1 in disease","Signaling by FGFR3 in disease","Toll Like Receptor 4 (TLR4) Cascade","G2/M Transition","Oxidative Stress Induced Senescence","PTK
6 promotes HIF1A stabilization","Semaphorin interactions","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Toll Like Receptor 5 (TLR5) Cascade","Glutamate binding","activ
ation of AMPA receptors and synaptic plasticity","Signaling by NTRK3 (TRKC)","Signaling by ROBO receptors","G1 Phase","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AKT network",
"EPH-Ephrin signaling","SARS-CoV-1 Infection","Leishmania parasite growth and survival","Interferon alpha/beta signaling","Caspase activation via Dependence Receptors in the absence of ligand","Transc
riptional regulation by RUNX1","PTEN Regulation","Host Interactions of HIV factors","HIV Life Cycle","Signaling by RAS mutants","Generation of second messenger molecules","Interleukin-2 family signali
ng","Toll Like Receptor 2 (TLR2) Cascade","Mitotic Anaphase","Signalling to ERKs","IRS-mediated signalling","Leishmania phagocytosis","VEGFR2 mediated cell proliferation","Regulation of TP53 Activity"
,"Imatinib-resistant PDGFR mutants","Dasatinib-resistant KIT mutants","FGFR1 mutant receptor activation","Signaling by FGFR3 point mutants in cancer","MyD88-independent TLR4 cascade","Centrosome matur
ation","Sema4D in semaphorin signaling","HDR through Homologous Recombination (HRR)","MyD88 cascade initiated on plasma membrane","Trafficking of AMPA receptors","Activated NTRK3 signals through PI3K"
,"Activation of RAC1","Cyclin D associated events in G1","Activation of TRKA receptors","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","EPHA-me
diated growth cone collapse","SARS-CoV-1 Genome Replication and Transcription","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of IFNA signaling","RUNX1 regulates tran
scription of genes involved in BCR signaling","EPHB-mediated forward signaling","Regulation of PTEN stability and activity","The role of Nef in HIV-1 replication and disease pathogenesis","Late Phase 
of HIV Life Cycle","Signaling downstream of RAS mutants","Interleukin-15 signaling","Toll Like Receptor TLR6:TLR2 Cascade","Separation of Sister Chromatids","Signalling to RAS","PI3K Cascade","FCGR3A-
mediated phagocytosis","Regulation of TP53 Activity through Phosphorylation","Signaling by activated point mutants of FGFR1","FGFR3 mutant receptor activation","Prolonged ERK activation events","TRIF(
TICAM1)-mediated TLR4 signaling","Loss of proteins required for interphase microtubule organization from the centrosome","Sema4D induced cell migration and growth-cone collapse","Homologous DNA Pairin
g and Strand Exchange","MAP kinase activation","Trafficking of GluR2-containing AMPA receptors","NGF-independant TRKA activation","Replication of the SARS-CoV-1 genome","FCGR3A-mediated IL10 synthesis
","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Transcription of the HIV genome","Regulation of TP53 Expression and Degradation","MyD88:MAL(TIRAP) c
ascade initiated on plasma membrane","p38MAPK events","Signaling by activated point mutants of FGFR3","Frs2-mediated activation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Loss of Nlp fro
m mitotic centrosomes","Presynaptic phase of homologous DNA pairing and strand exchange","ARMS-mediated activation","activated TAK1 mediates p38 MAPK activation","Nef Mediated CD4 Down-regulation","HI
V Transcription Elongation","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","Tat-mediated elongation of the HIV-1 transcript","CREB phosphorylation","Formation 
of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ENMD-2076,ENMD2076,934353-76-1,934353761,"ENMD 2076",ENMD-981693,ENMD981693,UNII-J6U9WP10T7,UNIIJ6U9WP10T7,CHEMBL482968,J6U9WP10T7,"934353-76-1 (free base)","934353761 (free base)",ENND-2076,ENND2076
,1291074-87-7,1291074877,cc-471,cc471,MLS006011042,SCHEMBL596481,GTPL7885,SCHEMBL10122872,SCHEMBL15668060,DTXSID60239430,EX-A235,EXA235,AOB8715,T2358,S1181}

> <pdid>
PD011101

> <targets>
{Flt,VEGFR,"Aurora Kinase"}

> <classes>
{}

> <pubchem_cids>
{16041424}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
    3.2256   -4.6869    0.0000 C   0  0
    2.7071   -3.2793    0.0000 O   0  0
    3.6667   -2.1252    0.0000 C   0  0
    5.1442   -2.3838    0.0000 C   0  0
    6.1069   -1.2335    0.0000 C   0  0
    5.5920    0.1754    0.0000 C   0  0
    4.1145    0.4339    0.0000 C   0  0
    3.6002    1.8430    0.0000 F   0  0
    3.1484   -0.7186    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 N   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.4523    2.0983    0.0000 C   0  0
   -3.8856    1.6561    0.0000 N   0  0
   -4.2194    0.1937    0.0000 C   0  0
   -5.6526   -0.2516    0.0000 N   0  0
   -5.9845   -1.7153    0.0000 C   0  0
   -7.4163   -2.1625    0.0000 C   0  0
   -7.7450   -3.6260    0.0000 C   0  0
   -6.6419   -4.6424    0.0000 C   0  0
   -6.9738   -6.1061    0.0000 C   0  0
   -5.8725   -7.1245    0.0000 O   0  0
   -8.4063   -6.5512    0.0000 O   0  0
   -5.2101   -4.1953    0.0000 C   0  0
   -4.1043   -5.2101    0.0000 O   0  0
   -2.6731   -4.7610    0.0000 C   0  0
   -4.8814   -2.7318    0.0000 C   0  0
   -3.1198   -0.8265    0.0000 N   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.5000   -2.8577    0.0000 C   0  0
   -0.7500   -4.1567    0.0000 C   0  0
    0.7500   -4.1567    0.0000 C   0  0
    1.5000   -5.4558    0.0000 Cl  0  0
    1.5000   -2.8577    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  7  9  2  0
  9  3  1  0
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 21 25  1  0
 25 26  1  0
 26 27  1  0
 25 28  2  0
 28 18  1  0
 16 29  1  0
 29 30  2  0
 30 13  1  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 34 36  1  0
 36 37  2  0
 37 10  1  0
 37 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28476

> <plate>
Kinase v5-2

> <well>
O05

> <supplier_cmpd_name>
MLN8237

> <ctcr_id>
2437

> <supplier_cmpd_id>
S1133

> <smiles>
COc1cccc(F)c1C2=NCc3cnc(Nc4ccc(C(O)=O)c(OC)c4)nc3c5ccc(Cl)cc25

> <pd_targets>
{LRRK2,AURKA,NTRK1,PTK2,ERBB4,LCK,RPS6KA3,GRK5,FGFR1,AURKB,EPHA2,FLT1,PDPK1,NTRK2,FGFR3,ABL1,RET,SRC,KDR,FRK,GABRA1,ROS1,PLK4,LTK,LIMK1,PIM3,CSNK2A1,SRPK1,BLK,SLK,NTRK3,TNK2,BTK,INCENP,EGFR,ERBB2,CDK8
,PRKACA,FER,CLK4,BRSK1}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Ligand-gated ion channel","Protein Kinase","GABA-A receptor","TKL protein kinase group","Other protein kinase group","TK protein kinase group","AGC protein kinase group",
"CAMK protein kinase group","CMGC protein kinase group","STE protein kinase group","TKL protein kinase LRRK family","Other protein kinase AUR family","Tyrosine protein kinase Trk family","Tyrosine pro
tein kinase Fak family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Src family","AGC protein kinase RSK family","AGC protein kinase GRK family","Tyrosine protein kinase FGFR family"
,"Tyrosine protein kinase Eph family","Tyrosine protein kinase VEGFR family","AGC protein kinase PDK1 subfamily","Tyrosine protein kinase Abl family","Tyrosine protein kinase Ret family","Tyrosine pro
tein kinase Sev family","Other protein kinase PLK family","Tyrosine protein kinase Alk family","TKL protein kinase LISK family","CAMK protein kinase PIM family","Other protein kinase CK2 family","CMGC
 protein kinase SRPK family","STE protein kinase STE20 family","Tyrosine protein kinase Ack family","Tyrosine protein kinase Tec family","CMGC protein kinase CDK family","AGC protein kinase PKA family
","Tyrosine protein kinase Fer family","CMGC protein kinase CLK family","CAMK protein kinase CAMK1 family","AGC protein kinase RSK subfamily","AGC protein kinase GRK subfamily","TKL protein kinase LIM
K subfamily","STE protein kinase SLK subfamily","CMGC protein kinase CDK8 subfamily","CAMK protein kinase BRSK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Kinases (EC 2.7.x.x)","Ligand-gated ion channels","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","GABA<sub>A</sub> receptors","CAM
K: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TKL: Tyrosine kinase-like","Other
 protein kinases","TK: Tyrosine kinase","RSK family","G protein-coupled receptor kinases (GRKs)","PDK1 family","PIM family","SRPK family","STE20 family","Cyclin-dependent kinase (CDK) family","Protein
 kinase A (PKA) family","CLK family","CAMK-like (CAMKL) family","Leucine-rich repeat kinase (LRRK) family","Aurora kinase (Aur) family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinase
s (nRTKs)","RSK subfamily","GRK4 subfamily","Polo-like kinase (PLK) family","LIM domain kinase (LISK) family","Casein kinase 2 (CK2) family","SLK subfamily","CDK8 subfamily","BRSK subfamily","Type VII
 RTKs: Neurotrophin receptor/Trk family","Fak family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Src family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type XII
I RTKs: Ephrin receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Abl family","Type XIV RTKs: RET","Type XVII RTKs: ROS receptors","Type XIX RTKs: Leukocyte ty
rosine kinase (LTK) receptor family","LIMK subfamily","Ack family","Tec family","Fer family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Disease,"Neuronal System","Immune System","Cell Cycle","Developmental Biology","Signaling by Non-Receptor Tyrosine Kinases","RNA Polymerase II 
Transcription","Signaling by Receptor Tyrosine Kinases","Infectious disease","Transmission across Chemical Synapses","Innate Immune System","Signaling by GPCR","Diseases of signal transduction by grow
th factor receptors and second messengers",Mitotic,"Nervous system development","Intracellular signaling by second messengers","Signaling by PTK6","Generic Transcription Pathway","Signaling by NTRKs",
"Leishmania infection","Neurotransmitter receptors and postsynaptic signal transmission","HIV Infection","Toll-like Receptor Cascades","GPCR downstream signalling","Signaling by FGFR in disease","M Ph
ase","Axon guidance","Signaling by VEGF","PIP3 activates AKT signaling","Mitotic G2-G2/M phases","Signaling by NOTCH1 in Cancer","Signaling by SCF-KIT","PTK6 promotes HIF1A stabilization","Transcripti
onal Regulation by TP53","Signaling by NTRK1 (TRKA)","Parasite infection","Activation of NMDA receptors and postsynaptic events","Host Interactions of HIV factors","Toll Like Receptor 5 (TLR5) Cascade
","G alpha (q) signalling events","Signaling by FGFR1 in disease","Mitotic Metaphase and Anaphase","EPH-Ephrin signaling","VEGF ligand-receptor interactions","Signaling by FGFR3 in disease","RET signa
ling","VEGFA-VEGFR2 Pathway","PTEN Regulation","GABA receptor activation","G2/M Transition","Semaphorin interactions","Transcriptional regulation by RUNX1","Signaling by NTRK3 (TRKC)","Signaling by NO
TCH1 HD+PEST Domain Mutants in Cancer","Regulation of TP53 Activity","Signalling to ERKs","Leishmania phagocytosis","Post NMDA receptor activation events","The role of Nef in HIV-1 replication and dis
ease pathogenesis","MyD88 cascade initiated on plasma membrane","FGFR1 mutant receptor activation","Mitotic Anaphase","EPHA-mediated growth cone collapse","VEGF binds to VEGFR leading to receptor dime
rization","Activation of TRKA receptors","Signaling by FGFR3 point mutants in cancer","VEGFR2 mediated cell proliferation","Regulation of PTEN stability and activity","Centrosome maturation","Sema4D i
n semaphorin signaling","RUNX1 regulates transcription of genes involved in BCR signaling","Activated NTRK3 signals through PI3K","Gastrin-CREB signalling pathway via PKC and MAPK","Constitutive Signa
ling by NOTCH1 HD+PEST Domain Mutants","Regulation of TP53 Activity through Phosphorylation","Prolonged ERK activation events","FCGR3A-mediated phagocytosis","Long-term potentiation","Nef-mediates dow
n modulation of cell surface receptors by recruiting them to clathrin adapters","MAP kinase activation","Signaling by activated point mutants of FGFR1","Separation of Sister Chromatids","Regulation of
 TP53 Expression and Degradation","NGF-independant TRKA activation","FGFR3 mutant receptor activation","Signalling to RAS","Loss of proteins required for interphase microtubule organization from the c
entrosome","Sema4D induced cell migration and growth-cone collapse","EGFR Transactivation by Gastrin","ARMS-mediated activation","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediat
ed by MAP kinases","Regulation of TP53 Degradation","Signaling by activated point mutants of FGFR3","p38MAPK events","Loss of Nlp from mitotic centrosomes","CREB phosphorylation"}

> <broad_targets>
{AURKA}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{Alisertib,1028486-01-2,1028486012,MLN8237,MLN-8237,"MLN8237 (Alisertib)","MLN 8237",UNII-T66ES73M18,UNIIT66ES73M18,CHEMBL483158,T66ES73M18,"Alisertib (USAN:INN)","Alisertib (MLN8237)","Alisertib (USA
N)","MLN8237,Alisertib",Kinome_3770,Kinome3770,Kinome-3770,"Kinome 3770",PubChem22398,"Alisertib; MLN8237",M,T2241,S1133,alisertib}

> <pdid>
PD003337

> <targets>
{Aurora,"Aurora Kinase",Apoptosis,Autophagy}

> <classes>
{Cell Cycle,Apoptosis,Autophagy,Cell Cycle/DNA Damage,Epigenetics}

> <pubchem_cids>
{24771867}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
    5.4926   -3.1514    0.0000 C   0  0
    4.0006   -3.3060    0.0000 C   0  0
    3.3872   -4.6758    0.0000 C   0  0
    4.2689   -5.8893    0.0000 C   0  0
    3.6587   -7.2596    0.0000 C   0  0
    2.1669   -7.4164    0.0000 C   0  0
    1.2853   -6.2028    0.0000 C   0  0
   -0.2070   -6.3627    0.0000 C   0  0
   -0.8152   -7.7339    0.0000 C   0  0
    1.8954   -4.8324    0.0000 C   0  0
    1.0157   -3.6164    0.0000 N   0  0
    1.6281   -2.2462    0.0000 C   0  0
    3.1202   -2.0921    0.0000 O   0  0
    0.7500   -1.0323    0.0000 N   0  0
    1.2135    0.3943    0.0000 C   0  0
    0.0000    1.2760    0.0000 C   0  0
   -0.4623    2.7009    0.0000 N   0  0
   -1.9623    2.7008    0.0000 N   0  0
   -2.4258    1.2743    0.0000 C   0  0
   -3.8515    0.8135    0.0000 N   0  0
   -4.9659    1.8188    0.0000 C   0  0
   -4.6522    3.2856    0.0000 O   0  0
   -6.3940    1.3573    0.0000 C   0  0
   -7.5092    2.3604    0.0000 C   0  0
   -8.9356    1.8962    0.0000 C   0  0
   -9.2468    0.4288    0.0000 C   0  0
   -8.1316   -0.5743    0.0000 C   0  0
   -6.7052   -0.1101    0.0000 C   0  0
  -10.6739   -0.0356    0.0000 N   0  0
  -11.7908    0.9658    0.0000 C   0  0
  -13.2164    0.4993    0.0000 C   0  0
  -13.5252   -0.9685    0.0000 N   0  0
  -14.9509   -1.4350    0.0000 C   0  0
  -12.4085   -1.9699    0.0000 C   0  0
  -10.9828   -1.5035    0.0000 C   0  0
   -1.2135    0.3943    0.0000 C   0  0
   -0.7500   -1.0323    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  7 10  2  0
 10  3  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 26 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 32 34  1  0
 34 35  1  0
 35 29  1  0
 19 36  1  0
 36 16  2  0
 36 37  1  0
 37 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28477

> <plate>
Kinase v5-2

> <well>
O07

> <supplier_cmpd_name>
PHA-680632

> <ctcr_id>
3352

> <supplier_cmpd_id>
S1454

> <smiles>
CCc1cccc(CC)c1NC(=O)N2Cc3[nH]nc(NC(=O)c4ccc(cc4)N5CCN(C)CC5)c3C2

> <pd_targets>
{AURKA,AURKB,AURKC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Aurora kinase (Aur) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","M Phase","Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase
","Regulation of TP53 Activity","Mitotic Anaphase","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HA68063,PHA-680632,PHA680632,398493-79-3,398493793,CHEMBL363160,"Pha 680632",cc-476,cc476,MLS006011048,SCHEMBL12582821,BDBM12110,DTXSID10460035,BCPP000111,C28H35N7O2,HMS3654D10,BCP02311,EX-A2893,EXA2
893,ZINC6718665,ABP000945,ANW-54326,ANW54326,BDBM50466806,s1454,AKOS015999833,CCG-2697,CCG2697,S1454}

> <pdid>
PD011187

> <targets>
{Aurora,"Aurora Kinase"}

> <classes>
{Cell Cycle,Cell Cycle/DNA Damage,Epigenetics}

> <pubchem_cids>
{11249084}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 35  0  0  0  0            999 V2000
    1.3000    2.2500    0.0000 C   0  0
    1.3000    0.7500    0.0000 S   0  0
    1.3000   -0.7500    0.0000 O   0  0
    0.0007    0.0004    0.0000 O   0  0
    2.5993    0.0004    0.0000 O   0  0
   20.7364    5.2377    0.0000 Cl  0  0
   21.3560    3.8717    0.0000 C   0  0
   22.8488    3.7253    0.0000 C   0  0
   23.4684    2.3592    0.0000 C   0  0
   22.5952    1.1396    0.0000 C   0  0
   21.1024    1.2859    0.0000 C   0  0
   20.2262    0.0674    0.0000 N   0  0
   18.7327    0.2160    0.0000 C   0  0
   18.1155    1.5831    0.0000 O   0  0
   17.8566   -1.0025    0.0000 N   0  0
   16.3657   -0.8542    0.0000 C   0  0
   15.3658   -1.9724    0.0000 S   0  0
   14.0123   -1.3561    0.0000 C   0  0
   12.7136   -2.1083    0.0000 C   0  0
   11.4123   -1.3606    0.0000 C   0  0
   10.1137   -2.1129    0.0000 N   0  0
    8.8124   -1.3651    0.0000 C   0  0
    8.8123    0.1349    0.0000 N   0  0
    7.5133    0.8849    0.0000 C   0  0
    6.2143    0.1349    0.0000 N   0  0
    6.2143   -1.3651    0.0000 C   0  0
    5.1000   -2.3681    0.0000 C   0  0
    5.7101   -3.7384    0.0000 C   0  0
    7.2019   -3.5816    0.0000 S   0  0
    7.5133   -2.1151    0.0000 C   0  0
   14.1450    0.1253    0.0000 C   0  0
   15.6111    0.4422    0.0000 N   0  0
   20.4828    2.6521    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  2  0
  2  5  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  1  0
 30 22  1  0
 30 26  2  0
 18 31  2  0
 31 32  1  0
 32 16  2  0
 11 33  2  0
 33  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28478

> <plate>
Kinase v5-2

> <well>
O09

> <supplier_cmpd_name>
SNS-314 Mesylate

> <ctcr_id>
5637

> <supplier_cmpd_id>
S1154

> <smiles>
C[S](O)(=O)=O.Clc1cccc(NC(=O)Nc2sc(CCNc3ncnc4ccsc34)cn2)c1

> <pd_targets>
{CSF1R,DDR2,NTRK1,NTRK2,AURKB,RAF1,FLT4,AURKA,AXL,KIT,CAMK2G,CDK8,PLK4,NTRK3,PDGFRB,SRPK1,MINK1,IRAK1,CAMK2B,HIPK4,SLK,PTK2,PRKCD,EPHA2,MELK,CAMK2D,CDK1,PRKD2,FRK,RPS6KB1,MKNK2,DYRK3,MAPK13,MET,ROCK2,
IRAK4,ROS1,CHEK2,CDK19,TYRO3,RET,CSNK1G2,BRSK1,MAP3K20,NEK4,KDR,CLK4,AURKC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","TKL protein kinase group","CAMK protein kinase group","CMGC protein kinase group","STE protein kinase group","AG
C protein kinase group","CK1 protein kinase group","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Trk family","Other protein kinase AUR family","T
KL protein kinase RAF family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Axl family","CAMK protein kinase CAMK2 family","CMGC protein kinase CDK family","Other protein kinase PLK 
family","CMGC protein kinase SRPK family","STE protein kinase STE20 family","TKL protein kinase IRAK family","CMGC protein kinase DYRK family","Tyrosine protein kinase Fak family","AGC protein kinase 
PKC family","Tyrosine protein kinase Eph family","CAMK protein kinase CAMK1 family","CAMK protein kinase PKD family","Tyrosine protein kinase Src family","AGC protein kinase RSK family","CAMK protein 
kinase MAPKAPK family","CMGC protein kinase MAPK family","Tyrosine protein kinase Met family","AGC protein kinase DMPK family","Tyrosine protein kinase Sev family","CAMK protein kinase RAD53 family","
Tyrosine protein kinase Ret family","CK1 protein kinase CK1 family","TKL protein kinase MLK family","Other protein kinase NEK family","CMGC protein kinase CLK family","CMGC protein kinase CDK8 subfami
ly","STE protein kinase MSN subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase SLK subfamily","AGC protein kinase PKC delta subfamily","CAMK protein kinase MELK subfamily","CMGC prote
in kinase CDC2 subfamily","AGC protein kinase p70 subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase Dyrk2 subfamily","CMGC protein kinase p38 subfamily","AGC protein kinase ROCK subf
amily","CAMK protein kinase BRSK subfamily","TKL protein kinase MLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs o
f yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase 1","TK: Tyrosine kinase","Other protein kinases","TKL: Tyrosine kinase-like","CAMK2 fa
mily","Cyclin-dependent kinase (CDK) family","SRPK family","STE20 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Protein kinase C (PKC) family","CAMK-like (CAM
KL) family","Protein kinase D (PKD) family","RSK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Mitogen-activated protein kinases (MAP kinases)","DMPK family","Casein kinase 1 (CK1) family"
,"CLK family","Receptor tyrosine kinases (RTKs)","Aurora kinase (Aur) family","RAF family","CDK8 subfamily","Polo-like kinase (PLK) family","MSN subfamily","Interleukin-1 receptor-associated kinase (I
RAK) family","HIPK subfamily","SLK subfamily","Non-receptor tyrosine kinases (nRTKs)","Delta subfamily","MELK subfamily","CDK1 subfamily","p70 subfamily","MKN subfamily","Dyrk2 subfamily","p38 subfami
ly","Rho kinase","CHK1 subfamily","BRSK subfamily","Mixed Lineage Kinase (MLK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor fami
ly","Type XVI RTKs: DDR (collagen receptor) family","Type VII RTKs: Neurotrophin receptor/Trk family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XI RTKs: TAM (TYRO
3-","AXL- and MER-TK) receptor family","Fak family","Type XIII RTKs: Ephrin receptor family","Src family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XVII RTKs: ROS receptors",
"Type XIV RTKs: RET","MLK subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Extracellular matrix organization","Signal Transduction","Cell Cycle",Disease,"Neuronal System","Cellular responses to external stimuli","Immune System","Developmen
tal Biology",Metabolism,"RNA Polymerase II Transcription","Non-integrin membrane-ECM interactions","Signaling by Receptor Tyrosine Kinases",Mitotic,"MAPK family signaling cascades","Diseases of signal
 transduction by growth factor receptors and second messengers","Transmission across Chemical Synapses","Intracellular signaling by second messengers","Cellular responses to stress","Innate Immune Sys
tem","Infectious disease","Nervous system development","Metabolism of lipids","MTOR signalling","Generic Transcription Pathway","Signaling by NTRKs","M Phase","MAPK1/MAPK3 signaling","Signaling by VEG
F","Signaling by KIT in disease","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by NOTCH1 in Cancer","Mitotic G2-G2/M phases","PIP3 activates AKT signaling","Cellular Sen
escence","Toll-like Receptor Cascades","Leishmania infection","DAG and IP3 signaling","Axon guidance","Regulation of mitotic cell cycle","Sphingolipid metabolism","mTORC1-mediated signalling","Regulat
ion of lipid metabolism by PPARalpha","Transcriptional Regulation by VENTX","Signaling by NTRK1 (TRKA)","Mitotic Metaphase and Anaphase","RAF/MAP kinase cascade","VEGF ligand-receptor interactions","T
ranscriptional Regulation by TP53","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","Activation of NMDA receptors and postsynaptic events","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer"
,"G2/M Transition","Signaling by NTRK3 (TRKC)","Negative regulation of the PI3K/AKT network","Oxidative Stress Induced Senescence","Toll Like Receptor 5 (TLR5) Cascade","Parasite infection","CaM pathw
ay","EPH-Ephrin signaling","APC/C-mediated degradation of cell cycle proteins","Sphingolipid de novo biosynthesis","PTEN Regulation","Semaphorin interactions","Toll Like Receptor 2 (TLR2) Cascade","PP
ARA activates gene expression","RET signaling","Signalling to ERKs","Activation of TRKA receptors","Mitotic Anaphase","Negative regulation of MAPK pathway","VEGF binds to VEGFR leading to receptor dim
erization","Regulation of TP53 Activity","Dasatinib-resistant KIT mutants","Post NMDA receptor activation events","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Centrosome maturation","Act
ivated NTRK3 signals through PI3K",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","MyD88 cascade initiated on plasma membrane","Leishmania phagocytosis","Calmodulin induced events","EPHA-mediated gr
owth cone collapse","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of PTEN stability and activity","Sema4D in semaphorin signaling","Toll Like Receptor TLR6
:TLR2 Cascade","VEGFR2 mediated cell proliferation","Prolonged ERK activation events","NGF-independant TRKA activation","Separation of Sister Chromatids","Negative feedback regulation of MAPK pathway"
,"Regulation of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Loss of proteins required for interphase microtubule organiza
tion from the centrosome","MAP kinase activation","FCGR3A-mediated phagocytosis","APC/C:Cdc20 mediated degradation of mitotic proteins","Signalling to RAS","Sema4D mediated inhibition of cell attachme
nt and migration","Sema4D induced cell migration and growth-cone collapse","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Regulation of TP53 Expression and Degradation","ARMS-mediated activa
tion","Ras activation upon Ca2+ influx through NMDA receptor","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK activation","APC:Cdc20 mediated degradation of cell cycle protein
s prior to satisfation of the cell cycle checkpoint","p38MAPK events","Regulation of TP53 Degradation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{AURKA,AURKB,AURKC}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{"SNS-314 Mesylate","SNS314 Mesylate",1146618-41-8,1146618418,UNII-KGW32FDY3U,UNIIKGW32FDY3U,"SNS 314 mesylate",KGW32FDY3U,"1146618-41-8 (mesylate)","1146618418 (mesylate)",cc-347,cc347,MLS006011040,C
19H19ClN6O4S3,CHEMBL518051,SCHEMBL17257952,DTXSID10648376,EX-A465,EXA465,HMS3654A12,BCP24792,s1154,AKOS015904656,T2617,S1154}

> <pdid>
PD005309

> <targets>
{"Aurora Kinases A",B,"& C",Aurora,"Aurora Kinase"}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{24995523}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -3.9069    5.2492    0.0000 N   0  0
   -5.2089    5.9957    0.0000 C   0  0
   -5.3543    7.4758    0.0000 C   0  0
   -6.8231    7.7802    0.0000 C   0  0
   -7.4401    9.1474    0.0000 C   0  0
   -7.5665    6.4774    0.0000 N   0  0
   -6.5572    5.3678    0.0000 N   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -6.4939    0.7411    0.0000 S   0  0
   -6.4894   -0.7597    0.0000 C   0  0
   -7.7846   -1.5163    0.0000 C   0  0
   -7.7770   -3.0163    0.0000 C   0  0
   -6.4742   -3.7597    0.0000 C   0  0
   -6.4636   -5.2605    0.0000 N   0  0
   -5.1590   -6.0025    0.0000 C   0  0
   -3.8651   -5.2437    0.0000 O   0  0
   -5.1483   -7.5033    0.0000 C   0  0
   -4.3923   -8.7072    0.0000 C   0  0
   -5.8923   -8.7147    0.0000 C   0  0
   -5.1790   -3.0032    0.0000 C   0  0
   -5.1866   -1.5032    0.0000 C   0  0
   -3.8967    0.7484    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 17 12  2  0
 10 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 30 28  1  0
 24 31  1  0
 31 32  2  0
 32 21  1  0
 19 33  2  0
 33  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28479

> <plate>
Kinase v5-2

> <well>
O11

> <supplier_cmpd_name>
VX-680

> <ctcr_id>
5907

> <supplier_cmpd_id>
S1048

> <smiles>
CN1CCN(CC1)c2cc(Nc3cc(C)[nH]n3)nc(Sc4ccc(NC(=O)C5CC5)cc4)n2

> <pd_targets>
{MAPKAPK2,NTRK1,MAP4K4,MAP4K1,STK4,AAK1,LYN,SRC,KDR,KIT,PDGFRA,CAMK1,NUAK1,MAP4K3,CHEK1,BRSK1,TYRO3,ROS1,RPS6KA2,CDKL5,TBK1,RIOK2,TAOK1,DDR1,MERTK,MET,TIE1,ABL1,FGFR1,LCK,PRKAA1,CSK,PRPF4B,CDKL2,MAP2K
5,AURKC,FLT3,AURKAIP1,INSR,PRKAA2,CDK16,JAK2,RET,MYLK,IKBKE,STK11,MARK3,AURKA,AURKB,PLK4,ALK,AURKB-A,PAK4,PAK2,MST1R,EIF2AK4,INSRR,NTRK3,EPHA2,EPHA1,TYK2,LIMK1,TESK1,PHKG1,PIP5K1A,MAP3K10,MYLK2,JAK3,N
EK5,PKN1,WEE2,SBK3,MELK,SYK,TNK1,SIK1,BCR,YES1,MAP2K2,CSNK2A1,MAP3K9,RIOK1,MAP3K11,CAMK1D,PAK3,PAK1,LIMK2,EPHA3,STK10,STK26,IGF1R,EPHB1,EPHB4,MYLK4,BTK,TEC,TGFBR1,PKNB,MAPK10,TNIK,PTK2B,DCLK3,MYLK3,CS
NK2A2,FGFR3,MAP3K4,STK24,MAP2K1,SIK2,MAP3K13,FER,PKN2,ABL2,STK3,GAK,ACVR1,BLK,FYN,FLT1,RIOK3,DDR2,ACVRL1,LATS1,LATS2,PRKCQ,PRKD2,FGFR4,FGR,MAP3K12,RIPK1,MINK1,MAP3K3,EPHB6,SRPK3,RIPK4,CDK11A,CSF1R,FRK
,MAP3K19,EPHA4,FGFR2,ITK,CDKL3,ERBB3,SLK,TEK,TAOK3,BMPR2,RPS6KB1,PDGFRB,NTRK2,FES,MAPK14,SRPK1,PAK5,MAP2K6,BMX,MAP4K5,RPS6KA3,MARK2,MARK1,DAPK3,TXK,IRAK3,RPS6KA1,JAK1,PHKG2,STK16,CDK11B,STK25,MARK4,WE
E1,TLK1,MUSK,AXL,CDK19,MAP3K7,LRRK2,NUAK2,BMP2K,PIP4K2B,TAOK2,BMPR1B,ANKK1,ERN1,CDK17,CAMKK1,ULK3,SRPK2,HUNK,EPHA6,EGFR,FLT4,EPHA8,GRK4,LTK,TNK2,NEK7,MAP3K20,MKNK2,MAP3K2,TTK,PAK6,HCK,MAPK7,DLK1,CYP19
A1,MAP4K2,IRAK4,EPHB2,STK17A,P2RY14,PRKCZ,STK38L,PDPK1,CAMK1G}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Membrane receptor",Kinase,Transferase,"Cytochrome P450","Family A G protein-coupled receptor","Protein Kinase","Cytochrome P450 family 19","Small molecule receptor (fam
ily A GPCR)","CAMK protein kinase group","TK protein kinase group","STE protein kinase group","Other protein kinase group","AGC protein kinase group","CMGC protein kinase group","Atypical protein kina
se group","TKL protein kinase group","Cytochrome P450 family 19A","Nucleotide-like receptor (family A GPCR)","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Trk family","STE protein kina
se STE20 family","Other protein kinase NAK family","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","CAMK protein kinase CAMK1 family"
,"Tyrosine protein kinase Axl family","Tyrosine protein kinase Sev family","AGC protein kinase RSK family","CMGC protein kinase CDKL family","Other protein kinase IKK family","Atypical protein kinase 
RIO family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Met family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Abl family","Tyrosine protein kinase FGFR family","T
yrosine protein kinase Csk family","STE protein kinase STE7 family","Other protein kinase AUR family","Tyrosine protein kinase InsR family","CMGC protein kinase CDK family","Tyrosine protein kinase Ja
kA family","Tyrosine protein kinase Ret family","CAMK protein kinase MLCK family","Other protein kinase PLK family","TKL protein kinase STKR family","Other protein kinase PEK family","Tyrosine protein
 kinase Eph family","TKL protein kinase LISK family","CAMK protein kinase PHk family","TKL protein kinase MLK family","Other protein kinase NEK family","AGC protein kinase PKN family","Other protein k
inase WEE family","Other protein kinase NKF1 family","Tyrosine protein kinase Syk family","Tyrosine protein kinase Ack family","Atypical protein kinase BCR family","Other protein kinase CK2 family","T
yrosine protein kinase Tec family","CMGC protein kinase MAPK family","Tyrosine protein kinase Fak family","CAMK protein kinase DCAMK1 family","STE protein kinase STE11 family","Tyrosine protein kinase
 Fer family","AGC protein kinase NDR family","AGC protein kinase PKC family","CAMK protein kinase PKD family","TKL protein kinase RIPK family","CMGC protein kinase SRPK family","Tyrosine protein kinas
e EGFR family","CAMK protein kinase DAPK family","TKL protein kinase IRAK family","Other protein kinase TLK family","Tyrosine protein kinase Musk family","TKL protein kinase LRRK family","Other protei
n kinase CAMKK family","Other protein kinase ULK family","AGC protein kinase GRK family","Tyrosine protein kinase Alk family","Other protein kinase TTK family","Cytochrome P450 19A1","Purine receptor"
,"AGC protein kinase PDK1 subfamily","CAMK protein kinase MAPKAPK subfamily","STE protein kinase MSN subfamily","STE protein kinase KHS subfamily","STE protein kinase MST subfamily","CAMK protein kina
se NuaK subfamily","CAMK protein kinase CHK1 subfamily","CAMK protein kinase BRSK subfamily","AGC protein kinase RSK subfamily","Atypical protein kinase RIO2 subfamily","STE protein kinase TAO subfami
ly","CAMK protein kinase AMPK subfamily","CMGC protein kinase TAIRE subfamily","CAMK protein kinase LKB subfamily","CAMK protein kinase MARK subfamily","TKL protein kinase STKR Type 1 subfamily","STE 
protein kinase PAKB subfamily","STE protein kinase PAKA subfamily","Other protein kinase GCN2 subfamily","TKL protein kinase LIMK subfamily","TKL protein kinase TESK subfamily","TKL protein kinase MLK
 subfamily","Other protein kinase WEE1","CAMK protein kinase MELK subfamily","CAMK protein kinase QIK subfamily","Atypical protein kinase RIO1 subfamily","STE protein kinase SLK subfamily","STE protei
n kinase YSK subfamily","CMGC protein kinase JNK subfamily","TKL protein kinase LZK subfamily","TKL protein kinase STKR1","Tyrosine protein kinase SrcA","Atypical protein kinase RIO3 subfamily","AGC p
rotein kinase PKC delta subfamily","STE protein kinase MEKK2","CMGC protein kinase PITSLRE subfamily","TKL protein kinase STKR Type 2 subfamily","AGC protein kinase p70 subfamily","CMGC protein kinase
 p38 subfamily","CMGC protein kinase CDK8 subfamily","TKL protein kinase TAK1 subfamily","CMGC protein kinase PCTAIRE","Other protein kinase Meta subfamily","AGC protein kinase GRK subfamily","CAMK pr
otein kinase MNK subfamily","CMGC protein kinase ERK5","AGC protein kinase PKC iota subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Cytochrome P450","G protein-coupled receptors","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","STE: Homologs o
f yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"Lipid modifying kinases",CYP11,CYP17,CYP19,"CYP2
0 and CYP21 families","P2Y receptors","MAPK-Activated Protein Kinase (MAPKAPK) family","TK: Tyrosine kinase","STE20 family","Other protein kinases","CAMK1 family","CAMK-like (CAMKL) family","RSK famil
y","Cyclin-dependent kinase-like (CDKL) family","RIO family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","STE7 family","Cyclin-dependent kinase (CDK) family","Myosin
 Light Chain Kinase (MLCK) family","TKL: Tyrosine kinase-like","Phosphorylase kinase (PHK) family","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","Protein kinase N (PKN) fam
ily","Mitogen-activated protein kinases (MAP kinases)","DCAMKL family","STE11 family","NDR family","Protein kinase C (PKC) family","Protein kinase D (PKD) family","SRPK family","Death-associated kinas
e (DAPK) family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","G protein-coupled receptor kinases (GRKs)","PDK1 family","MAPKAPK subfamily","Receptor tyrosine kinases (RT
Ks)","MSN subfamily","KHS subfamily","MST subfamily","NAK family","Non-receptor tyrosine kinases (nRTKs)","NuaK subfamily","CHK1 subfamily","BRSK subfamily","RSK subfamily","IKK family","RIO2 subfamil
y","TAO subfamily","AMPK subfamily","PRP4 subfamily","Aurora kinase (Aur) family","TAIRE subfamily","LKB subfamily","MARK subfamily","Polo-like kinase (PLK) family","PAKB subfamily","PAKA subfamily","
PEK family","LIM domain kinase (LISK) family","Mixed Lineage Kinase (MLK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","WEE family","NKF1 family","MELK subfamily","QIK subfami
ly","Casein kinase 2 (CK2) family","RIO1 subfamily","SLK subfamily","YSK subfamily","Receptor serine/threonine kinase (RSTK) family","JNK subfamily","Numb-associated kinase (NAK) family","RIO3 subfami
ly","Delta subfamily","Receptor interacting protein kinase (RIPK) family","PITSLRE subfamily","STE20 subfamily","p70 subfamily","p38 subfamily","Interleukin-1 receptor-associated kinase (IRAK) family"
,"Tousled-like kinase (TLK) family","CDK8 subfamily","Leucine-rich repeat kinase (LRRK) family","IRE family","CAMKK family","Unc-51-like kinase (ULK) family","HUNK subfamily","GRK4 subfamily","MKN sub
family","TTK family","ERK subfamily","Iota subfamily","Type VII RTKs: Neurotrophin receptor/Trk family","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III
 RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type XVII RTKs: ROS receptors","Type XVI RTKs: DDR (collagen receptor) family","Type X RTK
s: HGF (hepatocyte growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Abl family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Csk family","Type I
I RTKs: Insulin receptor family","Janus kinase (JakA) family","Type XIV RTKs: RET","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","GCN2 subfamily","Type XIII RTKs: Ephrin receptor fa
mily","LIMK subfamily","TESK subfamily","MLK subfamily","Syk family","Ack family","Tec family","Type I receptor serine/threonine kinases","Fak family","LZK subfamily","Fer family","Type I RTKs: ErbB (
epidermal growth factor) receptor family","Type II receptor serine/threonine kinases","Type IX RTKs: MuSK","TAK1 subfamily","Meta subfamily"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Cellular responses to external stimuli","Vesicle-mediated transport",Disease,"Neuronal System","Gene expression (Transcription)","DNA Repair","Metabolism of RNA
","Cell Cycle","Extracellular matrix organization",Hemostasis,"Developmental Biology","Metabolism of proteins","Cell-Cell communication",Metabolism,"Circadian Clock","Programmed Cell Death","Organelle
 biogenesis and maintenance","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Cellular responses to stress","Signaling by Hippo","Membrane Trafficking","Infectious disease","Diseases o
f signal transduction by growth factor receptors and second messengers","Transmission across Chemical Synapses","RNA Polymerase II Transcription","DNA Double-Strand Break Repair","rRNA processing",Mit
otic,"Non-integrin membrane-ECM interactions","Cell surface interactions at the vascular wall","Nervous system development",Translation,"Intracellular signaling by second messengers","Signaling by Rho
 GTPases","Cytokine Signaling in Immune system","Cell junction organization","Metabolism of carbohydrates","Metabolism of lipids",Apoptosis,"Signaling by TGFB family members","Signaling by GPCR","Adap
tive Immune System","MAPK family signaling cascades","MTOR signalling","Cilium Assembly","Cell Cycle Checkpoints","ECM proteoglycans","Signaling by Non-Receptor Tyrosine Kinases","Unfolded Protein Res
ponse (UPR)","Signaling by Hedgehog","Signaling by NOTCH","Biological oxidations","Signaling by Nuclear Receptors","Toll-like Receptor Cascades","Signaling by NTRKs","Cellular Senescence","Clathrin-me
diated endocytosis","Leishmania infection","Signaling by VEGF","Signaling by KIT in disease","Signaling by PDGFR in disease","Neurotransmitter receptors and postsynaptic signal transmission","Generic 
Transcription Pathway","Homology Directed Repair","rRNA processing in the nucleus and cytosol","M Phase","Axon guidance","Signaling by FGFR in disease","HIV Infection","Oncogenic MAPK signaling","Sign
aling by Insulin receptor","Mitochondrial translation","PIP3 activates AKT signaling","Mitotic G1 phase and G1/S transition","RHO GTPase Effectors","Mitotic G2-G2/M phases","Signaling by MST1","Respon
se of EIF2AK4 (GCN2) to amino acid deficiency","Interferon Signaling","Cell-extracellular matrix interactions","Glycogen metabolism","Phospholipid metabolism","Signaling by Interleukins","Neutrophil d
egranulation","Apoptotic execution phase","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Signaling by TGF-beta Receptor Complex in Cancer","Signaling by SCF-KIT","trans-Golgi Net
work Vesicle Budding","Signaling by BMP","GPCR downstream signalling","Sphingolipid metabolism","Signaling by FGFR","TCR signaling","MAPK1/MAPK3 signaling","mTORC1-mediated signalling","Caspase activa
tion via extrinsic apoptotic signalling pathway","Fc epsilon receptor (FCERI) signaling","Anchoring of the basal body to the plasma membrane","G2/M Checkpoints","Regulation of lipid metabolism by PPAR
alpha","Signaling by PTK6","IRE1alpha activates chaperones","Hedgehog 'on' state","Signaling by NOTCH1","Phase I - Functionalization of compounds","GPCR ligand binding","ESR-mediated signaling","Toll 
Like Receptor 5 (TLR5) Cascade","Signaling by NTRK1 (TRKA)","Oxidative Stress Induced Senescence","Cargo recognition for clathrin-mediated endocytosis","Leishmania parasite growth and survival","VEGFA
-VEGFR2 Pathway","Drug resistance of KIT mutants","Drug resistance of PDGFR mutants","Activation of NMDA receptors and postsynaptic events","Transcriptional Regulation by TP53","HDR through Homologous
 Recombination (HRR) or Single Strand Annealing (SSA)","Toll Like Receptor 4 (TLR4) Cascade","Major pathway of rRNA processing in the nucleolus and cytosol","Mitotic Metaphase and Anaphase","Semaphori
n interactions","Parasite infection","Signaling by FGFR1 in disease","Host Interactions of HIV factors","Signaling by RAS mutants","Insulin receptor signalling cascade","Mitochondrial translation elon
gation","Negative regulation of the PI3K/AKT network","G1 Phase","RET signaling","RHO GTPases activate PAKs","G2/M Transition","Signaling by ROBO receptors","Signaling by NTRK3 (TRKC)","EPH-Ephrin sig
naling","Interferon alpha/beta signaling","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Glycogen breakdown (glycogenolysis)","PI Metabolism","Interleukin-2 fami
ly signaling","RHO GTPases activate PKNs","Apoptotic cleavage of cellular proteins","IGF1R signaling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Loss of Function of SMAD2/3 in Cancer"
,"Signaling by FGFR3 in disease","Golgi Associated Vesicle Biogenesis","Transcriptional regulation by RUNX1","VEGF ligand-receptor interactions","G alpha (i) signalling events","Sphingolipid de novo b
iosynthesis","Signaling by FGFR4","Interleukin-1 family signaling","Transcriptional Regulation by VENTX","PTEN Regulation","Signaling by FGFR2 in disease","Generation of second messenger molecules","R
AF/MAP kinase cascade","Caspase activation via Dependence Receptors in the absence of ligand","FCERI mediated Ca+2 mobilization","Toll Like Receptor 2 (TLR2) Cascade","Antiviral mechanism by IFN-stimu
lated genes","G2/M DNA damage checkpoint","PPARA activates gene expression","PTK6 promotes HIF1A stabilization","G alpha (q) signalling events","Mitotic Prophase","Activated NOTCH1 Transmits Signal to
 the Nucleus","Cytochrome P450 - arranged by substrate type","Class A/1 (Rhodopsin-like receptors)","Extra-nuclear estrogen signaling","MyD88 cascade initiated on plasma membrane","Signalling to ERKs"
,"Anti-inflammatory response favouring Leishmania parasite infection","VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","Imatinib-resistant PDGFR mutants","Post NMDA receptor acti
vation events","Regulation of TP53 Activity","HDR through Homologous Recombination (HRR)","MyD88-independent TLR4 cascade","Mitotic Anaphase","Sema4D in semaphorin signaling","Leishmania phagocytosis"
,"FGFR1 mutant receptor activation","The role of Nef in HIV-1 replication and disease pathogenesis","Signaling downstream of RAS mutants","Signalling to ERK5","IRS-mediated signalling",PI5P,"PP2A and 
IER3 Regulate PI3K/AKT Signaling","Cyclin D associated events in G1","Centrosome maturation","Activation of RAC1","Activated NTRK3 signals through PI3K","EPHA-mediated growth cone collapse","Regulatio
n of IFNA signaling","Synthesis of PIPs at the plasma membrane","Interleukin-15 signaling","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Ephrin sig
naling","EPHB-mediated forward signaling","IRS-related events triggered by IGF1R","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Interleukin-2 signaling","Signaling by FGFR3 point mutants in cance
r","Role of ABL in ROBO-SLIT signaling","RUNX1 regulates transcription of genes involved in BCR signaling","VEGF binds to VEGFR leading to receptor dimerization","Visual phototransduction","Downstream
 signaling of activated FGFR4","Interleukin-1 signaling","Regulation of PTEN stability and activity","FGFR2 mutant receptor activation","Activation of TRKA receptors","CRMPs in Sema3A signaling","Toll
 Like Receptor TLR6:TLR2 Cascade","ISG15 antiviral mechanism","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Gastrin-CREB signalling pathway via PKC and MAPK","Nuclear Envelope Brea
kdown","Endogenous sterols","Nucleotide-like (purinergic) receptors","Estrogen-stimulated signaling through PRKCZ","MAP kinase activation","Prolonged ERK activation events","FCGR3A-mediated IL10 synth
esis","Signalling to RAS","Activation of RAC1 downstream of NMDARs","Regulation of TP53 Activity through Phosphorylation","Homologous DNA Pairing and Strand Exchange","TRIF(TICAM1)-mediated TLR4 signa
ling","Separation of Sister Chromatids","Sema4D mediated inhibition of cell attachment and migration","FCGR3A-mediated phagocytosis","Signaling by activated point mutants of FGFR1","Nef-mediates down 
modulation of cell surface receptors by recruiting them to clathrin adapters","PI3K Cascade","Loss of proteins required for interphase microtubule organization from the centrosome","Nef and signal tra
nsduction","Sema4D induced cell migration and growth-cone collapse","FGFR3 mutant receptor activation","The phototransduction cascade","FRS-mediated FGFR4 signaling","Recruitment of mitotic centrosome
 proteins and complexes","Activated point mutants of FGFR2","NGF-independant TRKA activation","Regulation of TP53 Activity through Acetylation","MyD88:MAL(TIRAP) cascade initiated on plasma membrane",
"EGFR Transactivation by Gastrin","Activation of NIMA Kinases NEK9",NEK6,NEK7,"P2Y receptors","Regulation of TP53 Expression and Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","AR
MS-mediated activation","p38MAPK events","Presynaptic phase of homologous DNA pairing and strand exchange","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Nef Mediated CD4 Down-regulation","Lo
ss of Nlp from mitotic centrosomes","Frs2-mediated activation","Signaling by activated point mutants of FGFR3",Inactivation,"recovery and regulation of the phototransduction cascade","IKK complex recr
uitment mediated by RIP1","PI5P Regulates TP53 Acetylation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Regulation of TP53 Degradation","CREB phosphorylation","Activation of the AP
-1 family of transcription factors","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{X68,Tozasertib,639089-54-6,639089546,VX-680,VX680,MK-0457,MK0457,"MK 0457","VX 680","VX-680 (MK-0457,Tozasertib)","VX680 (MK0457,Tozasertib)",UNII-234335M86K,UNII234335M86K,VX-68,VX68,"Tozasertib (VX
-680)","Tozasertib (VX680)",MK-045,MK045,L-001281814,L001281814,CHEMBL572878,936915-58-1,936915581,VX6,234335M86K,"Tozasertib (USAN)","Tozasertib (USAN:INN)","VE 465",T2509,S1048,TOZASERTIB}

> <pdid>
PD003407

> <targets>
{Aurora,ABL,"AURORA KINASES",FLT3,"Aurora Kinase",Autophagy}

> <classes>
{Autophagy,Cell Cycle/DNA Damage,Epigenetics}

> <pubchem_cids>
{5494449}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2982    3.7531    0.0000 N   0  0
    1.2960    5.2539    0.0000 C   0  0
    2.5925    6.0085    0.0000 C   0  0
    2.5873    7.5085    0.0000 C   0  0
    1.2856    8.2540    0.0000 C   0  0
    1.2773    9.7548    0.0000 N   0  0
   -0.0261   10.4989    0.0000 C   0  0
   -1.3212    9.7421    0.0000 O   0  0
   -0.0344   11.9997    0.0000 C   0  0
   -1.3360   12.7452    0.0000 C   0  0
   -1.3412   14.2452    0.0000 C   0  0
   -0.0448   14.9997    0.0000 C   0  0
    1.2568   14.2543    0.0000 C   0  0
    1.2621   12.7543    0.0000 C   0  0
   -0.0108    7.4995    0.0000 C   0  0
   -0.0056    5.9995    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 N   0  0
   -3.9099   -8.2497    0.0000 C   0  0
   -3.9099   -9.7497    0.0000 C   0  0
   -2.6109  -10.4997    0.0000 O   0  0
   -1.3119   -9.7497    0.0000 C   0  0
   -1.3118   -8.2497    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 11 21  1  0
 21 22  2  0
 22  8  1  0
  6 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26  5  1  0
 26 27  1  0
 27 28  2  0
 28  3  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28480

> <plate>
Kinase v5-2

> <well>
O13

> <supplier_cmpd_name>
ZM-447439

> <ctcr_id>
2962

> <supplier_cmpd_id>
S1103

> <smiles>
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN5CCOCC5

> <pd_targets>
{LCK,TNK2,AURKA,RORC,ROCK2,AURKB,RET,KDR,MET,EGFR,MAPT,TYRO3,BTK,PDGFRA,NTRK2,ALDH1A1,AURKB-A,FYN,LTK,MAP2K2,MAP4K5,MAP2K1}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Other cytosolic protein",Kinase,"Nuclear receptor",Oxidoreductase,"Protein Kinase","Nuclear hormone receptor subfamily 1","TK protein kinase group","Other protein kinas
e group","Nuclear hormone receptor subfamily 1 group F","AGC protein kinase group","STE protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase Ack family","Other protein k
inase AUR family","Nuclear hormone receptor subfamily 1 group F member 3","AGC protein kinase DMPK family","Tyrosine protein kinase Ret family","Tyrosine protein kinase VEGFR family","Tyrosine protein
 kinase Met family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Tec family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Trk 
family","Tyrosine protein kinase Alk family","STE protein kinase STE7 family","STE protein kinase STE20 family","AGC protein kinase ROCK subfamily","Tyrosine protein kinase SrcA","STE protein kinase K
HS subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Receptor kinases","1F. Retinoic acid-related orphans","AGC: Containing PKA",PKG,"PKC families","STE: Homolo
gs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","Other protein kinases","DMPK family","STE7 family","STE20 family","Non-receptor tyrosine kinases (nRTKs)","Aurora kinase
 (Aur) family","Rho kinase","Receptor tyrosine kinases (RTKs)","KHS subfamily","Src family","Ack family","Type XIV RTKs: RET","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family",
"Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Tec family",
"Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Developmental Biology","Cell Cycle","Signal Transduction","Neuronal System",Metabolism,"Infectious disease","RNA Polymerase II Transcription","Nervous syste
m development",Mitotic,"Signaling by Receptor Tyrosine Kinases","Signaling by GPCR","Transmission across Chemical Synapses","Diseases of signal transduction by growth factor receptors and second messe
ngers","Biological oxidations","HIV Infection","Generic Transcription Pathway","Axon guidance","M Phase","Signaling by VEGF","GPCR downstream signalling","Neurotransmitter receptors and postsynaptic s
ignal transmission","Leishmania infection","Signaling by PDGFR in disease","Signaling by NTRKs","Phase I - Functionalization of compounds","Host Interactions of HIV factors","Transcriptional Regulatio
n by TP53","Transcriptional regulation by RUNX3","Semaphorin interactions","Mitotic Metaphase and Anaphase","RET signaling","VEGFA-VEGFR2 Pathway","G alpha (q) signalling events","Activation of NMDA r
eceptors and postsynaptic events","Parasite infection","Drug resistance of PDGFR mutants","Signaling by NTRK1 (TRKA)","Ethanol oxidation","The role of Nef in HIV-1 replication and disease pathogenesis
","Regulation of TP53 Activity","RUNX3 Regulates Immune Response and Cell Migration","Sema4D in semaphorin signaling","Mitotic Anaphase","VEGFR2 mediated cell proliferation","Gastrin-CREB signalling p
athway via PKC and MAPK","Post NMDA receptor activation events","Leishmania phagocytosis","Imatinib-resistant PDGFR mutants","Activation of TRKA receptors","Signalling to ERKs","Nef-mediates down modu
lation of cell surface receptors by recruiting them to clathrin adapters","Regulation of TP53 Activity through Phosphorylation","Sema4D induced cell migration and growth-cone collapse","Separation of 
Sister Chromatids","Sema4D mediated inhibition of cell attachment and migration","EGFR Transactivation by Gastrin","Activation of AMPK downstream of NMDARs","FCGR3A-mediated phagocytosis","NGF-indepen
dant TRKA activation","Nef and signal transduction","Prolonged ERK activation events","Nef Mediated CD4 Down-regulation","Frs2-mediated activation"}

> <broad_targets>
{AURKA,AURKB}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{331771-20-1,331771201,ZM-447439,ZM447439,"ZM 447439",TCMDC-125873,TCMDC125873,UNII-RSN3P9776R,UNIIRSN3P9776R,CHEMBL202721,RSN3P9776R,C29H31N5O4,Kinome_3319,Kinome3319,Kinome-3319,"Kinome 3319",NCGC00
159574-01,NCGC0015957401,PubChem24158,cc-90,cc90,MLS006010133,SCHEMBL597105,GTPL8353,BDBM14210,CHEBI:91376,AOB2181,DTXSID00186833,BCPP000002,S1103,2458}

> <pdid>
PD011136

> <targets>
{Aurora,"AURORA KINASE B"}

> <classes>
{}

> <pubchem_cids>
{9914412}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 24  0  0  1  0            999 V2000
    9.0983   -0.7368    0.0000 O   0  0
    7.8003   -1.4887    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0  1  0  0  0
    6.4964    0.7591    0.0000 O   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -3.9021   -3.7405    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2088   -5.9860    0.0000 I   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0127   -6.0039    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  6
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 22 16  1  0
 22 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28481

> <plate>
Kinase v5-2

> <well>
O15

> <supplier_cmpd_name>
AS703026

> <ctcr_id>
7572

> <supplier_cmpd_id>
S1475

> <smiles>
OC[C@@H](O)CNC(=O)c1ccncc1Nc2ccc(I)cc2F

> <pd_targets>
{MAP2K1,MAP2K2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","STE protein kinase STE7 family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","STE7 family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by NTRKs","Signaling by NTRK1 (TRKA)","Signalling to ERKs","Prolonged ERK activation events","Frs2-mediated activation"}

> <broad_targets>
{MAP2K1,MAP2K2}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{Pimasertib,1236699-92-5,1236699925,AS703026,"Pimasertib (AS-703026)","Pimasertib (AS703026)",AS-703026,MSC1936369B,"AS 703026",UNII-6ON9RK82AL,UNII6ON9RK82AL,6ON9RK82AL,1204531-26-9,1204531269,"(S)-N
-(2,3-dihydroxypropyl)-3-(2-fluoro-4-iodophenylamino)isonicotinamide","(S)N(2,3dihydroxypropyl)3(2fluoro4iodophenylamino)isonicotinamide",C15H15FIN3O3,(S)-N-(2,(S)N(2,3-dihydroxypropyl),3dihydroxyprop
yl),S1475}

> <pdid>
PD011176

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{44187362}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 F   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
    1.2946    3.7547    0.0000 C   0  0
    2.5943    3.0056    0.0000 C   0  0
    3.8928    3.7565    0.0000 C   0  0
    3.8918    5.2565    0.0000 C   0  0
    5.1903    6.0074    0.0000 Br  0  0
    2.5923    6.0056    0.0000 C   0  0
    1.2937    5.2548    0.0000 C   0  0
   -0.0058    6.0039    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 N   0  0
   -5.2003    1.4932    0.0000 O   0  0
   -6.4990    0.7409    0.0000 C   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0983    0.7368    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 10  1  0
 16 17  1  0
  8 18  2  0
 18 19  1  0
 19 20  2  0
 20  2  1  0
 20  5  1  0
 18 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28482

> <plate>
Kinase v5-2

> <well>
O17

> <supplier_cmpd_name>
AZD6244(Selumetinib)

> <ctcr_id>
2560

> <supplier_cmpd_id>
S1008

> <smiles>
Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO

> <pd_targets>
{EGFR,MAP2K1,MAP2K2,MAP3K1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","STE protein kinase group","Tyrosine protein kinase EGFR family","STE protein kinase STE7 family","STE protein kinase STE11 family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","STE7 family","Receptor ty
rosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family","STE11 family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by GPCR","Signaling by Receptor Tyrosine Kinases","GPCR downstream signalling","Signaling by NTRKs","G alpha (q) signalling events","Signaling by NTRK1 (TRKA)","Gastr
in-CREB signalling pathway via PKC and MAPK","Signalling to ERKs","EGFR Transactivation by Gastrin","Prolonged ERK activation events","Frs2-mediated activation","Immune System","Innate Immune System",
"Toll-like Receptor Cascades","Toll Like Receptor 2 (TLR2) Cascade","Toll Like Receptor TLR6:TLR2 Cascade","MyD88:MAL(TIRAP) cascade initiated on plasma membrane"}

> <broad_targets>
{MAP2K1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{Selumetinib,606143-52-6,606143526,AZD6244,"AZD 6244",ARRY-142886,ARRY142886,AZD-6244,"Selumetinib (AZD6244)","ARRY 142886","AZD6244 (Selumetinib)",ARRY-886,ARRY886,UNII-6UH91I579U,UNII6UH91I579U,CHEM
BL1614701,CHEBI:90227,6UH91I579U,NCGC00189073-01,NCGC0018907301,NCGC00189073-02,NCGC0018907302,C17H15BrClFN4O,T2508,T6218,S1008,Binimetinib,AZD6244(Selumetinib)}

> <pdid>
PD003249

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{10127622}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 N   0  0
    1.3039   -3.7494    0.0000 C   0  0
    2.6005   -2.9949    0.0000 C   0  0
    3.9021   -3.7404    0.0000 C   0  0
    3.9073   -5.2404    0.0000 C   0  0
    5.2089   -5.9859    0.0000 I   0  0
    2.6108   -5.9949    0.0000 C   0  0
    1.3092   -5.2494    0.0000 C   0  0
    0.0128   -6.0039    0.0000 F   0  0
   -2.6003   -1.4978    0.0000 C   0  0
   -2.6029   -2.9978    0.0000 O   0  0
   -3.8990   -0.7455    0.0000 N   0  0
   -5.2003   -1.4932    0.0000 O   0  0
   -6.4990   -0.7410    0.0000 C   0  0
   -7.8003   -1.4887    0.0000 C   0  0
   -9.0983   -0.7369    0.0000 O   0  0
    0.0000    3.0000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  3
  8  2  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 10  1  0
 16 17  1  0
  7 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
  5 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28483

> <plate>
Kinase v5-2

> <well>
O19

> <supplier_cmpd_name>
AZD8330

> <ctcr_id>
195

> <supplier_cmpd_id>
S2134

> <smiles>
CN1C(=O)C(=CC(=C1Nc2ccc(I)cc2F)C(=O)NOCCO)C

> <pd_targets>
{MAP2K1,MAP2K2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","STE protein kinase STE7 family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","STE7 family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by NTRKs","Signaling by NTRK1 (TRKA)","Signalling to ERKs","Prolonged ERK activation events","Frs2-mediated activation"}

> <broad_targets>
{MAP3K1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{AZD8330,869357-68-6,869357686,AZD-8330,ARRY-424704,ARRY424704,ARRY-704,ARRY704,"AZD 8330",UNII-G4990BOZ66,UNIIG4990BOZ66,G4990BOZ66,"ARRY-424704, ARRY-704","ARRY424704, ARRY704",C16H17FIN3O4,"ARRY 42
4704",MLS006011055,SCHEMBL388533,GTPL8474,CHEMBL3182621,CHEBI:91424,DTXSID50235986,QCR-188,QCR188,SYN1195,BCPP000359,HMS3,T6083,S2134}

> <pdid>
PD010850

> <targets>
{MEK}

> <classes>
{MAPK}

> <pubchem_cids>
{16666708}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
   -7.5971   -7.5137    0.0000 C   0  0
   -6.9950   -6.1399    0.0000 N   0  0
   -7.8835   -4.9303    0.0000 C   0  0
   -9.3744   -5.0953    0.0000 O   0  0
   -7.2810   -3.5557    0.0000 C   0  0
   -8.1672   -2.3455    0.0000 C   0  0
   -7.5623   -0.9729    0.0000 C   0  0
   -6.0711   -0.8105    0.0000 C   0  0
   -5.1849   -2.0207    0.0000 C   0  0
   -3.7607   -1.5523    0.0000 N   0  0
   -3.7663   -0.0523    0.0000 C   0  0
   -2.5561    0.8339    0.0000 O   0  0
   -5.1947    0.4059    0.0000 C   0  0
   -5.6603    1.8299    0.0000 C   0  0
   -4.6589    2.9478    0.0000 N   0  0
   -5.1253    4.3743    0.0000 C   0  0
   -6.5925    4.6865    0.0000 C   0  0
   -7.0558    6.1131    0.0000 C   0  0
   -6.0520    7.2277    0.0000 C   0  0
   -4.5848    6.9156    0.0000 C   0  0
   -3.5781    8.0287    0.0000 C   0  0
   -2.1105    7.7143    0.0000 N   0  0
   -1.1044    8.8268    0.0000 C   0  0
   -1.6497    6.2869    0.0000 C   0  0
   -4.1215    5.4889    0.0000 C   0  0
   -7.1289    2.1387    0.0000 C   0  0
   -7.5977    3.5637    0.0000 C   0  0
   -9.0660    3.8703    0.0000 C   0  0
  -10.0657    2.7521    0.0000 C   0  0
   -9.5971    1.3271    0.0000 C   0  0
   -8.1288    1.0205    0.0000 C   0  0
   -5.7898   -3.3933    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13  8  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 20 25  2  0
 25 16  1  0
 14 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
  9 32  2  0
 32  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28484

> <plate>
Kinase v5-2

> <well>
O21

> <supplier_cmpd_name>
BIX 02188

> <ctcr_id>
7150

> <supplier_cmpd_id>
S1530

> <smiles>
CNC(=O)c1ccc2c(NC(=O)\C2=C(Nc3cccc(CN(C)C)c3)\c4ccccc4)c1

> <pd_targets>
{MAPK7}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase ERK5"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{S1530,"BIX 02188"}

> <pdid>
PD010989

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{23507698}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 39  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 C   0  0
    3.8976    0.7554    0.0000 O   0  0
    2.5951    3.0039    0.0000 N   0  0
    3.8933    3.7570    0.0000 C   0  0
    3.8933    5.2571    0.0000 C   0  0
    5.1924    6.0071    0.0000 C   0  0
    6.4914    5.2571    0.0000 C   0  0
    7.7896    6.0103    0.0000 O   0  0
    7.7874    7.5111    0.0000 C   0  0
    6.4858    8.2566    0.0000 C   0  0
    6.4805    9.7566    0.0000 C   0  0
    7.7770   10.5112    0.0000 N   0  0
    9.0786    9.7657    0.0000 C   0  0
   10.3750   10.5202    0.0000 N   0  0
    9.0838    8.2657    0.0000 C   0  0
   10.3855    7.5203    0.0000 Cl  0  0
    6.4915    3.7571    0.0000 C   0  0
    7.7905    3.0072    0.0000 F   0  0
    5.1925    3.0071    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -6.4995    3.7442    0.0000 F   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 18 20  2  0
 20 14  1  0
 20 21  1  0
 12 22  1  0
 22 23  1  0
 22 24  2  0
 24  9  1  0
  5 25  1  0
 25 26  2  0
 25 27  1  0
 27 28  1  0
 28 29  2  3
 29  4  1  0
 27 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 33 35  1  0
 35 36  2  0
 36 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28485

> <plate>
Kinase v5-2

> <well>
A04

> <supplier_cmpd_name>
BMS 777607

> <ctcr_id>
6140

> <supplier_cmpd_id>
S1561

> <smiles>
CCOC1=C(C(=O)Nc2ccc(Oc3ccnc(N)c3Cl)c(F)c2)C(=O)N(C=C1)c4ccc(F)cc4

> <pd_targets>
{PDGFRA,AXL,FLT3,MET,KDR,KIT,MERTK,TYRO3,LCK,MST1R,NTRK2,RET,NTRK1,AURKB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Met family",
"Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Trk family","Tyrosine protein kinase Ret family","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Aurora kinase (Aur) family
","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type IV RTKs: VEG
F (vascular endothelial growth factor) receptor family","Src family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XIV RTKs: RET"}

> <pathway_reactome>
{Disease,"Signal Transduction","Developmental Biology",Hemostasis,"Cell Cycle","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinase
s","Nervous system development","Cell surface interactions at the vascular wall","Infectious disease",Mitotic,"Signaling by PDGFR in disease","Signaling by VEGF","Signaling by Insulin receptor","Axon 
guidance","Signaling by KIT in disease","HIV Infection","Signaling by MST1","Signaling by NTRKs","M Phase","Drug resistance of PDGFR mutants","VEGFA-VEGFR2 Pathway","Insulin receptor signalling cascad
e","Semaphorin interactions","Drug resistance of KIT mutants","Host Interactions of HIV factors","Signaling by NTRK1 (TRKA)","RET signaling","Mitotic Metaphase and Anaphase","Imatinib-resistant PDGFR 
mutants","IRS-mediated signalling","Sema4D in semaphorin signaling","VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","The role of Nef in HIV-1 replication and disease pathogenesi
s","Activation of TRKA receptors","Signalling to ERKs","Mitotic Anaphase","PI3K Cascade","Sema4D mediated inhibition of cell attachment and migration","Nef-mediates down modulation of cell surface rec
eptors by recruiting them to clathrin adapters","NGF-independant TRKA activation","Prolonged ERK activation events","Separation of Sister Chromatids","Nef Mediated CD4 Down-regulation","ARMS-mediated 
activation"}

> <broad_targets>
{AXL,MERTK,MET,MST1R,TYRO3}

> <broad_moa>
{"AXL kinase inhibitor","c-Met inhibitor","FLT3 inhibitor","hepatocyte growth factor receptor inhibitor","macrophage migration inhibiting factor inhibitor","tyrosine kinase inhibitor"}

> <synonyms>
{BMS-777607,BMS777607,1025720-94-8,1025720948,"BMS 777607",1196681-44-3,1196681443,ASLAN-002,ASLAN002,UNII-A3MMS6HDO1,UNIIA3MMS6HDO1,A3MMS6HDO1,"BMS 817378",BMS777606,cc-417,cc417,MLS006010958,C25H19C
lF2N4O4,CHEMBL460702,GTPL7953,SCHEMBL2588311,BDBM28031,CHEBI:91409,DTXSID50145278,EX-A,EXA,T2699,S1561}

> <pdid>
PD010971

> <targets>
{MEK,Axl,c-Met}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{24794418}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 C   0  0
   -3.8976    0.7553    0.0000 O   0  0
   -2.5951    3.0039    0.0000 N   0  0
   -3.8933    3.7570    0.0000 O   0  0
   -3.8912    5.2578    0.0000 C   0  0
   -5.1894    6.0109    0.0000 C   0  0
   -5.8603    7.2642    0.0000 C   0  0
   -6.6103    5.9651    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -2.5795   -7.5040    0.0000 I   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -5.1932   -3.0130    0.0000 Cl  0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 11  1  0
  5 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 22 16  1  0
 22 23  1  0
 14 24  2  0
 24  2  1  0
 24 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28486

> <plate>
Kinase v5-2

> <well>
A06

> <supplier_cmpd_name>
CI-1040 (PD184352)

> <ctcr_id>
6788

> <supplier_cmpd_id>
S1020

> <smiles>
Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

> <pd_targets>
{MAP2K1,CSNK2A1,PDGFRB,CAMK2A,MAP2K2,RAF1,AURKC,CSNK2A2,CSNK2A3,CSNK2B}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","Other protein kinase group","TK protein kinase group","CAMK protein kinase group","TKL protein kinase group","STE protein kinase STE7 family
","Other protein kinase CK2 family","Tyrosine protein kinase PDGFR family","CAMK protein kinase CAMK2 family","TKL protein kinase RAF family","Other protein kinase AUR family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kina
ses","STE7 family","Other protein kinases","TK: Tyrosine kinase","CAMK2 family","TKL: Tyrosine kinase-like","Casein kinase 2 (CK2) family","Receptor tyrosine kinases (RTKs)","RAF family","Aurora kinas
e (Aur) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Neuronal System","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Intracellular signaling by second messengers","Tr
ansmission across Chemical Synapses","MAPK family signaling cascades","Signaling by NTRKs","Generic Transcription Pathway","PIP3 activates AKT signaling","Neurotransmitter receptors and postsynaptic s
ignal transmission","MAPK1/MAPK3 signaling","Signaling by NTRK1 (TRKA)","Transcriptional Regulation by TP53","Negative regulation of the PI3K/AKT network","Activation of NMDA receptors and postsynapti
c events","RAF/MAP kinase cascade","Signalling to ERKs","Regulation of TP53 Activity",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Post NMDA receptor activation events","Negative regulation of MA
PK pathway","Prolonged ERK activation events","Regulation of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Negative feedbac
k regulation of MAPK pathway","Frs2-mediated activation","Ras activation upon Ca2+ influx through NMDA receptor"}

> <broad_targets>
{MAP2K1,MAP3K1,MAP3K2}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{"I1040 (PD184352",212631-79-3,212631793,CI-1040,CI1040,PD184352,"PD 184352",PD-184352,"2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide","2(2chloro4iodophenylamino)N(cyclop
ropylmethoxy)3,4difluorobenzamide","PD184352 (CI-1040)","PD184352 (CI1040)","CI 1040",2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,2(2chloro4iodophenylamino)Ncyclopropylmethoxy3,4-difluorobe,
4difluorobe,T2443,S1020,"CI-1040 (PD184352)"}

> <pdid>
PD011192

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{6918454}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 28  0  0  0  0            999 V2000
   10.3996   -1.4837    0.0000 O   0  0
    9.0990   -0.7364    0.0000 C   0  0
    7.8003   -1.4887    0.0000 C   0  0
    7.8029   -2.9887    0.0000 O   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 O   0  0
    3.8990   -0.7455    0.0000 N   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Br  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 F   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 N   0  0
   -1.2946   -3.7547    0.0000 C   0  0
   -2.5943   -3.0056    0.0000 C   0  0
   -3.8928   -3.7565    0.0000 C   0  0
   -3.8918   -5.2565    0.0000 C   0  0
   -5.1904   -6.0073    0.0000 I   0  0
   -2.5923   -6.0056    0.0000 C   0  0
   -1.2937   -5.2548    0.0000 C   0  0
    0.0058   -6.0039    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 16 18  2  0
 18 10  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 20  1  0
 26 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28487

> <plate>
Kinase v5-2

> <well>
A08

> <supplier_cmpd_name>
PD318088

> <ctcr_id>
3190

> <supplier_cmpd_id>
S1568

> <smiles>
OCC(O)CONC(=O)c1cc(Br)c(F)c(F)c1Nc2ccc(I)cc2F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{PD318088,391210-00-7,391210007,PD-318088,PD0318088,"PD 318088",C16H13BrF3IN2O4,cc-457,cc457,MLS006011053,SCHEMBL2721678,CHEMBL3182051,AOB4984,DTXSID50437004,BCPP000120,HMS3655I05,BCP02260,EX-A2126,EX
A2126,ABP000924,s1568,AKOS027314103,BCP9001066,CCG-270050,CCG270050,CS-0222,CS0222,NCGC0,T6152,S1568}

> <pdid>
PD003682

> <targets>
{MEK}

> <classes>
{MAPK}

> <pubchem_cids>
{10231331}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  0  0            999 V2000
   10.3996   -1.4837    0.0000 O   0  0
    9.0990   -0.7364    0.0000 C   0  0
    7.8003   -1.4887    0.0000 C   0  0
    7.8029   -2.9887    0.0000 O   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 O   0  0
    3.8990   -0.7455    0.0000 N   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 F   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 N   0  0
   -1.2946   -3.7547    0.0000 C   0  0
   -2.5943   -3.0056    0.0000 C   0  0
   -3.8928   -3.7565    0.0000 C   0  0
   -3.8918   -5.2565    0.0000 C   0  0
   -5.1904   -6.0073    0.0000 I   0  0
   -2.5923   -6.0056    0.0000 C   0  0
   -1.2937   -5.2548    0.0000 C   0  0
    0.0058   -6.0039    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  1  0
 15 17  2  0
 17 10  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
 25 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28488

> <plate>
Kinase v5-2

> <well>
A10

> <supplier_cmpd_name>
PD0325901

> <ctcr_id>
2413

> <supplier_cmpd_id>
S1036

> <smiles>
OCC(O)CONC(=O)c1ccc(F)c(F)c1Nc2ccc(I)cc2F

> <pd_targets>
{MAP2K2,MAP2K1,BRAF,MAPK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","TKL protein kinase group","CMGC protein kinase group","STE protein kinase STE7 family","TKL protein kinase RAF family","CMGC protein kinase 
MAPK family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families",
"STE7 family","TKL: Tyrosine kinase-like","Mitogen-activated protein kinases (MAP kinases)","RAF family","ERK subfamily"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Signaling by NTRKs","Toll-like Receptor Cascades","Signaling by NTRK1 (TRKA)","Toll Like Recepto
r 5 (TLR5) Cascade","Signalling to ERKs","MyD88 cascade initiated on plasma membrane","Prolonged ERK activation events","MAP kinase activation","Frs2-mediated activation","ARMS-mediated activation","M
APK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{MAP2K1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{"N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide","N(2,3dihydroxypropoxy)3,4difluoro2(2fluoro4iodoanilino)benzamide",391209-97-5,391209975,SCHEMBL453656,CHEMBL450775,CHEBI:9
4389,HMS3244G07,HMS3244G08,HMS3244H07,HMS3295C05,HMS3654C09,BCP01841,MFCD09909925,AKOS015896067,ES-0007,ES0007,NCGC00189075-02,NCGC0018907502,AC-,AC,S1036,PD0325901}

> <pdid>
PD006105

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{10206158}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  1  0            999 V2000
    6.4924   -3.7566    0.0000 C   0  0
    5.1945   -3.0045    0.0000 N   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0  1  0  0  0
    3.8991   -0.7525    0.0000 C   0  0  2  0  0  0
    3.9015    0.7475    0.0000 O   0  0
    5.1969   -1.5045    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
    0.0036   -7.4988    0.0000 C   0  0
   -1.2942   -8.2509    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 C   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -3.8971   -5.2550    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  6
  6  8  1  0
  8  2  1  0
  5  9  1  6
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  1  0
 21  9  1  0
 21 15  2  0
 19 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28489

> <plate>
Kinase v5-2

> <well>
A12

> <supplier_cmpd_name>
Flavopiridol(Alvocidib)

> <ctcr_id>
7720

> <supplier_cmpd_id>
S1230

> <smiles>
CN1CC[C@@H]([C@H](O)C1)c2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccccc4Cl

> <pd_targets>
{PIP5K1C,DSTYK,EGFR,PYGM,CAMKK1,CDK16,CDK2,CAMK2A,RPS6KA2,MKNK2,CLK1,CAMK2B,CDK14,AXL,RPS6KA6,STK3,CIT,CSF1R,CDK3,NUAK2,EPHA1,CCNE1,CCNE2,CCNB1,CCNB2,CCNB3,CDK1,CCND1,CDK4,PRKCE,PRKCH,KIT,ACVR2B,ALK,A
CVRL1,MAP4K1,ULK2,IRAK4,CDK15,LRRK2,DYRK1A,PRKCD,PIM3,GSK3A,ABL1,PRKCQ,MAPK7,RPS6KA4,AAK1,EIF2AK2,STK32A,IRAK1,CDK6,CAMKK2,CRK2,GAK,EPHA5,STK17B,FLT3,CDK17,CDK18,PHKG1,CDK19,CDK8,MAP3K9,CDC42BPB,DCLK1
,DCLK3,CDK13,MAPK3,CDK7,CDK9,CCND2,CCND3,CDK5,CDK5R1,PIM1,CLK2,PHKG2,MAP3K10,SRMS,PKN1,TBK1,TAOK3,CCNT1,CCNA2,PRKCA,PRKCB,PRKCG,PRKCI,PRKCZ,PRKD1,PRKD3,LCK,PDGFRA,MERTK,TAOK2,TAOK1,MAP3K7,CSNK1A1L,DYR
K1B,MAP2K3,MAPK15,PRKD2,RPS6KA1,MINK1,IKBKE,ACVR1,MAPK10,GRK1,CDKL5,CCNA1,CAMK2G,DMPK,STK17A,HIPK2,GRK7,GSK3-BETA,CCNH,PIM2,EPHB1,PRKAA1,FRK,PTK2B,CDC42BPA,EPHA3,MAPK8,JAK3,RPS6KA3,CSNK1A1,MAP4K2,TYK2
,JAK2,MAP4K3,ROCK1,CILK1,STK35,PLK4,CAMK4,CSNK1G1,SRC,GSK3B,BMPR1B,MAP3K3,RPS6KB1,STK33,TNNI3K,LTK,MAP2K4,VRK2,EIF2AK1,PIP4K2C,HIPK4,MAP2K5,HIPK1,ERBB4,ERBB3,ROCK2,CLK3,RPS6KA5,CAMK2D,TGFBR2,EPHA2,LAR
P7,ERBB2,ACVR2A,HIPK3,MAK,MAP3K2,MNAT1,GRK5,MAPK13,CLK4,MATK,MAPK14,SRPK1,MAPK12,MAP4K5,PKN2,SYK,ROS1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Transferase,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","CMGC protein kinase group","CAMK protein kinase group","AGC protein kinase gr
oup","STE protein kinase group","TKL protein kinase group","CK1 protein kinase group","Tyrosine protein kinase EGFR family","Other protein kinase CAMKK family","CMGC protein kinase CDK family","CAMK p
rotein kinase CAMK2 family","AGC protein kinase RSK family","CAMK protein kinase MAPKAPK family","CMGC protein kinase CLK family","Tyrosine protein kinase Axl family","STE protein kinase STE20 family"
,"AGC protein kinase DMPK family","Tyrosine protein kinase PDGFR family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Eph family","AGC protein kinase PKC family","TKL protein kinase STK
R family","Other protein kinase ULK family","TKL protein kinase IRAK family","TKL protein kinase LRRK family","CMGC protein kinase DYRK family","CAMK protein kinase PIM family","CMGC protein kinase GS
K family","Tyrosine protein kinase Abl family","CMGC protein kinase MAPK family","Other protein kinase NAK family","Other protein kinase PEK family","AGC protein kinase YANK family","CAMK protein kina
se DAPK family","CAMK protein kinase PHk family","TKL protein kinase MLK family","CAMK protein kinase DCAMK1 family","Tyrosine protein kinase Src family","AGC protein kinase PKN family","Other protein
 kinase IKK family","CK1 protein kinase CK1 family","STE protein kinase STE7 family","CAMK protein kinase PKD family","AGC protein kinase GRK family","CMGC protein kinase CDKL family","Tyrosine protei
n kinase Fak family","Tyrosine protein kinase JakA family","CMGC protein kinase RCK family","Other protein kinase NKF4 family","Other protein kinase PLK family","STE protein kinase STE11 family","CAMK
 protein kinase unique family","Tyrosine protein kinase Alk family","Other protein kinase Meta subfamily","CMGC protein kinase TAIRE subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase
 RSK subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase PFTAIRE","STE protein kinase MST subfamily","AGC protein kinase CRIK subfamily","CAMK protein kinase NuaK subfamily","AGC prote
in kinase PKC eta subfamily","TKL protein kinase STKR Type 2 subfamily","TKL protein kinase STKR Type 1 subfamily","STE protein kinase KHS subfamily","CMGC protein kinase Dyrk1 subfamily","AGC protein
 kinase PKC delta subfamily","CMGC protein kinase ERK5","AGC protein kinase MSK subfamily","Other protein kinase PKR","CMGC protein kinase PCTAIRE","CMGC protein kinase CDK8 subfamily","TKL protein ki
nase MLK subfamily","AGC protein kinase GEK subfamily","CMGC protein kinase ERK1","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK5 subfamily","Tyrosi
ne protein kinase Srm","STE protein kinase TAO subfamily","AGC protein kinase PKC alpha subfamily","TKL protein kinase TAK1 subfamily","CK1 protein kinase CK1-a","STE protein kinase MSN subfamily","TK
L protein kinase STKR1","CMGC protein kinase JNK subfamily","AGC protein kinase GRK subfamily","CMGC protein kinase HIPK subfamily","CAMK protein kinase AMPK subfamily","AGC protein kinase ROCK subfam
ily","CMGC protein kinase MAK","STE protein kinase MEKK2","AGC protein kinase p70 subfamily","TKL protein kinase HH498 subfamily","Other protein kinase HRI","Tyrosine protein kinase Csk family","CMGC 
protein kinase SRPK family","Tyrosine protein kinase Syk family","Tyrosine protein kinase Sev family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein
 kinases","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5
-kinase family)","Other protein kinases","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","CAMK2 family","RSK family","MAPK-Activated Protein Kinase (MAPKAPK) family","CLK family","STE20 f
amily","DMPK family","CAMK-like (CAMKL) family","Protein kinase C (PKC) family","TKL: Tyrosine kinase-like","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","PIM family",
"Glycogen synthase kinase (GSK) family","Mitogen-activated protein kinases (MAP kinases)","YANK family","Death-associated kinase (DAPK) family","Phosphorylase kinase (PHK) family","DCAMKL family","Pro
tein kinase N (PKN) family","Casein kinase 1 (CK1) family","STE7 family","Protein kinase D (PKD) family","G protein-coupled receptor kinases (GRKs)","Cyclin-dependent kinase-like (CDKL) family","RCK f
amily","CAMK1 family","STE11 family","CAMK-unique family","Vaccina related kinase (VRK) family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Other-unique family","Recept
or tyrosine kinases (RTKs)","CAMKK family","TAIRE subfamily","CDK1 subfamily","RSK subfamily","MKN subfamily","MST subfamily","Other DMPK family kinases","NuaK subfamily","Eta subfamily","Receptor ser
ine/threonine kinase (RSTK) family","KHS subfamily","Unc-51-like kinase (ULK) family","Interleukin-1 receptor-associated kinase (IRAK) family","Leucine-rich repeat kinase (LRRK) family","Dyrk1 subfami
ly","CDK4 subfamily","Delta subfamily","GSK subfamily","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","MSK subfamily","NAK family","PEK family","Numb-associated kinase (NAK) family","CDK8 sub
family","Mixed Lineage Kinase (MLK) family","GEK subfamily","CRK7 subfamily","CDK7 subfamily","CDK9 subfamily","CDK5 subfamily","IKK family","TAO subfamily","Erk7 subfamily","MSN subfamily","JNK subfa
mily","Opsin/rhodopsin kinases","HIPK subfamily","AMPK subfamily","Rho kinase","NKF4 family","Polo-like kinase (PLK) family","p70 subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor famil
y","Meta subfamily","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIII RTKs: Ephrin receptor family","Type II receptor ser
ine/threonine kinases","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type I receptor serine/threonine kinases","Abl family","Other PEK family kinases","MLK subfamily","Src family",
"TAK1 subfamily","Fak family","Janus kinase (JakA) family","HH498 subfamily","SRPK family","GRK4 subfamily","p38 subfamily","Csk family","Syk family","Type XVII RTKs: ROS receptors"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction",Metabolism,"Neuronal System","Gene expression (Transcription)","Immune System",Disease,"Cell Cycle","Vesicle-mediated transport",Hemostasis,"Cellular res
ponses to external stimuli","Muscle contraction","Nervous system development","Signaling by GPCR","Metabolism of carbohydrates","Transmission across Chemical Synapses","RNA Polymerase II Transcription
","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Signaling by Hippo","Signaling by Rho GTPases","Diseases of signal transduction by growth factor receptors and second messengers","Si
gnaling by NODAL","Signaling by TGFB family members","Signaling by Non-Receptor Tyrosine Kinases",Mitotic,"Intracellular signaling by second messengers","Infectious disease","Membrane Trafficking","Me
tabolism of lipids","Cell surface interactions at the vascular wall","Cellular responses to stress","Cardiac conduction","Cytokine Signaling in Immune system","Disorders of Developmental Biology","MTO
R signalling","Axon guidance","GPCR downstream signalling","Glycogen metabolism","Neurotransmitter receptors and postsynaptic signal transmission","Generic Transcription Pathway","Toll-like Receptor C
ascades","Signaling by VEGF","RHO GTPase Effectors","Fcgamma receptor (FCGR) dependent phagocytosis","Signaling by KIT in disease","Regulation of signaling by NODAL","Signaling by BMP","Signaling by P
TK6","Mitotic G1 phase and G1/S transition","DAG and IP3 signaling","SARS-CoV Infections","Leishmania infection","Clathrin-mediated endocytosis","Influenza Infection","trans-Golgi Network Vesicle Budd
ing","Signaling by Insulin receptor","Regulation of lipid metabolism by PPARalpha","Signaling by NOTCH1 in Cancer","HIV Infection","FLT3 signaling in disease","Signaling by PDGFR in disease","M Phase"
,"Sphingolipid metabolism","Cellular Senescence","Regulation of mitotic cell cycle","Ion homeostasis","PIP3 activates AKT signaling","Signaling by Interleukins","Signaling by WNT in cancer","Interfero
n Signaling","Mitotic G2-G2/M phases","Disorders of Nervous System Development","Signaling by NTRKs","mTORC1-mediated signalling","Response of EIF2AK1 (HRI) to heme deficiency","Signaling by TGF-beta 
Receptor Complex in Cancer","Semaphorin interactions","G alpha (q) signalling events","Glycogen breakdown (glycogenolysis)","Activation of NMDA receptors and postsynaptic events","Transcriptional Regu
lation by TP53","Toll Like Receptor 5 (TLR5) Cascade","VEGFA-VEGFR2 Pathway","RHO GTPases activate CIT","Transcriptional Regulation by VENTX","EPH-Ephrin signaling","Role of phospholipids in phagocyto
sis","G alpha (z) signalling events","Drug resistance of KIT mutants","Toll Like Receptor 2 (TLR2) Cascade","PTK6 promotes HIF1A stabilization","G0 and Early G1","G1 Phase","CaM pathway","SARS-CoV-1 I
nfection","Parasite infection","G alpha (i) signalling events","L1CAM interactions","Cargo recognition for clathrin-mediated endocytosis","NS1 Mediated Effects on Host Pathways","Golgi Associated Vesi
cle Biogenesis","Insulin receptor signalling cascade","PPARA activates gene expression","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","HIV Life Cycle","Signaling by FLT3 ITD and TKD mutants",
"PTK6 Down-Regulation","RHO GTPases activate PKNs","Toll Like Receptor 4 (TLR4) Cascade","Host Interactions of HIV factors","Drug resistance of PDGFR mutants","Mitotic Metaphase and Anaphase","Sphingo
lipid de novo biosynthesis","Oxidative Stress Induced Senescence","APC/C-mediated degradation of cell cycle proteins","PTEN Regulation","Interleukin-2 family signaling","Signaling by AMER1 mutants","I
nterferon alpha/beta signaling","G2/M Transition","Pervasive developmental disorders","Signaling by NTRK1 (TRKA)","Interleukin-1 family signaling","Negative regulation of the PI3K/AKT network","Loss o
f Function of SMAD2/3 in Cancer","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Gastrin-CREB signalling pathway via PKC and MAPK","Post NMDA receptor activation events","Regulati
on of TP53 Activity","MyD88 cascade initiated on plasma membrane","EPHA-mediated growth cone collapse","Dasatinib-resistant KIT mutants","Toll Like Receptor TLR6:TLR2 Cascade","Cyclin D associated eve
nts in G1","Calmodulin induced events","SARS-CoV-1 Genome Replication and Transcription","Leishmania phagocytosis","Visual phototransduction","Recycling pathway of L1","Inhibition of PKR","IRS-mediate
d signalling","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","TP53 Regulates Transcription of DNA Repair Genes","Late Phase of HIV Life Cycle","STAT5 activation downstream of FLT3 ITD mutan
ts","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","MyD88-independent TLR4 cascade","The role of Nef in HIV-1 replication and disease pathogenesis","
Imatinib-resistant PDGFR mutants","Mitotic Anaphase","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","EPHB-mediated forward signaling","Regulation of PTEN stability and 
activity","Interleukin-2 signaling","Interleukin-15 signaling","Truncations of AMER1 destabilize the destruction complex","Regulation of IFNA signaling","Sema4D in semaphorin signaling","Centrosome ma
turation","Loss of function of MECP2 in Rett syndrome","Signalling to ERKs","Interleukin-1 signaling","Signalling to ERK5",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","SMAD2/3 Phosphorylation Mot
if Mutants in Cancer","EGFR Transactivation by Gastrin","Activation of RAC1 downstream of NMDARs","Regulation of TP53 Expression and Degradation","CREB1 phosphorylation through NMDA receptor-mediated 
activation of RAS signaling","MAP kinase activation","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Replication of the SARS-CoV-1 genome","FCGR3A-mediated phagocytosis","The phototransductio
n cascade","Activation of AMPK downstream of NMDARs","PI3K Cascade","Transcription of the HIV genome","Regulation of TP53 Activity through Phosphorylation","TRIF(TICAM1)-mediated TLR4 signaling","Nef-
mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Separation of Sister Chromatids","APC/C:Cdc20 mediated degradation of mitotic proteins","Sema4D induced cel
l migration and growth-cone collapse","Loss of proteins required for interphase microtubule organization from the centrosome","Loss of phosphorylation of MECP2 at T308","Signalling to RAS","Nuclear En
velope (NE) Reassembly","Regulation of TP53 Activity through Acetylation","Long-term potentiation","Regulation of TP53 Degradation","Ras activation upon Ca2+ influx through NMDA receptor","MAPK target
s/ Nuclear events mediated by MAP kinases","RSK activation",Inactivation,"recovery and regulation of the phototransduction cascade","activated TAK1 mediates p38 MAPK activation","HIV Transcription Elo
ngation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Nef Mediated CD4 Down-regulation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","APC:Cdc20 mediated degradation of cel
l cycle proteins prior to satisfation of the cell cycle checkpoint","Loss of Nlp from mitotic centrosomes","p38MAPK events","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated h
uman TAK1","Initiation of Nuclear Envelope (NE) Reformation","PI5P Regulates TP53 Acetylation","CREB phosphorylation","ERK/MAPK targets","Tat-mediated elongation of the HIV-1 transcript","Activation o
f the AP-1 family of transcription factors","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated","Formation of HIV-1 elongation complex containing HIV-1 Tat","Signaling by ERB
B2","Downregulation of ERBB2 signaling","Leishmania parasite growth and survival","Anti-inflammatory response favouring Leishmania parasite infection","FCGR3A-mediated IL10 synthesis"}

> <broad_targets>
{CDK1,CDK2,CDK4,CDK5,CDK6,CDK7,CDK8,CDK9,EGFR,PYGM}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{Flavopiridol,Alvocidib,146426-40-6,146426406,"146426 40 6","Flavopiridol (Alvocidib)","L 868275",L-868275,L868275,L86-8275,"L86 8275",UNII-45AD6X575G,UNII45AD6X575G,"UNII 45AD6X575G","HMR 1274",13174
0-09-5,131740095,"131740 09 5","L 86-8275",S1230,"Flavopiridol (Alvocidib)",Flavopiridol(Alvocidib)}

> <pdid>
PD003362

> <targets>
{CDK}

> <classes>
{}

> <pubchem_cids>
{5287969}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 29  0  0  0  0            999 V2000
    0.0007    0.0004    0.0000 C   0  0
    1.3000    0.7500    0.0000 C   0  0
    2.5993    0.0004    0.0000 O   0  0
   10.2954    2.2466    0.0000 N   0  0
   10.2980    0.7466    0.0000 C   0  0
    8.9994   -0.0057    0.0000 S   0  0
    7.6981    0.7421    0.0000 C   0  0
    7.6981    2.2421    0.0000 C   0  0
    6.3990    2.9921    0.0000 C   0  0
    5.1000    2.2421    0.0000 C   0  0
    5.1000    0.7421    0.0000 C   0  0
    6.3990   -0.0079    0.0000 C   0  0
    6.3990   -1.5079    0.0000 N   0  0
   11.5993   -0.0011    0.0000 C   0  0
   11.6020   -1.5020    0.0000 C   0  0
   11.6046   -3.0020    0.0000 N   0  0
   12.8980    0.7511    0.0000 C   0  0
   12.8954    2.2520    0.0000 C   0  0
   12.8928    3.7520    0.0000 N   0  0
   14.1993    0.0034    0.0000 C   0  0
   14.2019   -1.4966    0.0000 N   0  0
   15.4980    0.7557    0.0000 S   0  0
   16.7993    0.0079    0.0000 C   0  0
   16.7994   -1.4921    0.0000 C   0  0
   18.0985   -2.2421    0.0000 C   0  0
   19.3975   -1.4921    0.0000 C   0  0
   19.3974    0.0079    0.0000 C   0  0
   18.0984    0.7579    0.0000 C   0  0
   18.0984    2.2579    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 12 13  1  0
  5 14  2  3
 14 15  1  0
 15 16  3  0
 14 17  1  0
 17 18  1  0
 18 19  3  0
 17 20  2  3
 20 21  1  0
 20 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28490

> <plate>
Kinase v5-2

> <well>
A14

> <supplier_cmpd_name>
U0126-EtOH

> <ctcr_id>
6954

> <supplier_cmpd_id>
S1102

> <smiles>
CCO.NC(Sc1ccccc1N)=C(C#N)C(C#N)=C(N)Sc2ccccc2N

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{0126ETO,1173097-76-1,1173097761,"U0126 Ethanol",HMS3654G21,BCP05458,AK548481,T6223,S1102,U0126-EtOH}

> <pdid>
PD014850

> <targets>
{MEK}

> <classes>
{MAPK}

> <pubchem_cids>
{91997702}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 42  0  0  0  0            999 V2000
   -1.2250   -6.6252    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
    1.2443   -5.8182    0.0000 C   0  0
    0.2425   -6.9344    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -4.2067    3.2905    0.0000 N   0  0
   -2.7390    2.9810    0.0000 C   0  0
   -1.6193    3.9803    0.0000 C   0  0
   -0.1673    3.6256    0.0000 C   0  0
    0.8689    4.7101    0.0000 C   0  0
    0.4478    6.1498    0.0000 C   0  0
    1.4840    7.2343    0.0000 F   0  0
   -1.0096    6.5049    0.0000 C   0  0
   -2.0458    5.4204    0.0000 C   0  0
   -6.4444    1.8313    0.0000 C   0  0
   -7.0532    0.4604    0.0000 C   0  0
   -7.3276    3.0437    0.0000 C   0  0
   -7.9360    1.6729    0.0000 C   0  0
    6.3536    1.6499    0.0000 C   0  0
    6.3536    0.1499    0.0000 S   0  0
    6.3536   -1.3501    0.0000 O   0  0
    5.0543   -0.5997    0.0000 O   0  0
    7.6529   -0.5997    0.0000 O   0  0
   11.4536    1.6499    0.0000 C   0  0
   11.4536    0.1499    0.0000 S   0  0
   11.4536   -1.3501    0.0000 O   0  0
   10.1543   -0.5997    0.0000 O   0  0
   12.7529   -0.5997    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  7  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
 13 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 16  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 24 26  1  0
 26 27  2  0
 27 21  1  0
 18 28  1  0
 28 29  1  0
 28 30  1  0
 28 31  1  0
 32 33  1  0
 33 34  1  0
 33 35  2  0
 33 36  2  0
 37 38  1  0
 38 39  1  0
 38 40  2  0
 38 41  2  0
M  END
> <name>
UTKinase_V5

> <id>
28491

> <plate>
Kinase v5-2

> <well>
A16

> <supplier_cmpd_name>
LY2228820

> <ctcr_id>
6238

> <supplier_cmpd_id>
S1494

> <smiles>
CC(C)(C)Cn1c(N)nc2ccc(nc12)c3[nH]c(nc3c4ccc(F)cc4)C(C)(C)C.C[S](O)(=O)=O.C[S](O)(=O)=O

> <pd_targets>
{MAPK14,MAPK11}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{CCG-270240,CCG270240,BCP9000872,LY2228820,862507-23-1,862507231,"Ralimetinib Mesylate","LY2228820 diMesylate","Ralimetinib dimesylate",UNII-QUW7B71FO9,UNIIQUW7B71FO9,"862507-23-1 (mesylate)","8625072
31 (mesylate)","LY 2228820",QUW7B71FO9,"Ralimetinib mesylate (USAN)",LY-2228820,"LY2228820 2MsOH",cc-430,cc430,SCH,T6047,S1494}

> <pdid>
PD016528

> <targets>
{"p38 MAPK",Apoptosis,Autophagy}

> <classes>
{MAPK,Apoptosis,Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{11570805}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
    9.4354   -7.1382    0.0000 C   0  0
    9.0116   -5.6993    0.0000 C   0  0
    7.5536   -5.3469    0.0000 C   0  0
    7.1297   -3.9080    0.0000 C   0  0
    8.1609   -2.8260    0.0000 C   0  0
    9.6219   -3.1739    0.0000 C   0  0
   10.0458   -4.6128    0.0000 C   0  0
    7.8525   -1.3573    0.0000 N   0  0
    8.8523   -0.2390    0.0000 N   0  0
    8.0978    1.0574    0.0000 C   0  0
    6.6317    0.7404    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 N   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 O   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 O   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -3.8933    3.7570    0.0000 C   0  0
   -3.8912    5.2578    0.0000 N   0  0
   -5.1876    6.0124    0.0000 C   0  0
   -5.1824    7.5124    0.0000 C   0  0
   -3.8808    8.2579    0.0000 O   0  0
   -2.5844    7.5034    0.0000 C   0  0
   -2.5896    6.0034    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    8.7025    2.4282    0.0000 C   0  0
   10.1936    2.5911    0.0000 C   0  0
    7.8162    3.6384    0.0000 C   0  0
    9.3071    3.8009    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  8  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 20 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 17  1  0
 35 30  1  0
 10 36  1  0
 36 37  1  0
 36 38  1  0
 36 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28492

> <plate>
Kinase v5-2

> <well>
A18

> <supplier_cmpd_name>
BIRB 796

> <ctcr_id>
2076

> <supplier_cmpd_id>
S1574

> <smiles>
Cc1ccc(cc1)n2nc(cc2NC(=O)Nc3ccc(OCCN4CCOCC4)c5ccccc35)C(C)(C)C

> <pd_targets>
{MAPK11,LCK,EGFR,MAPK9,MAPK14,MAPK10,EPHB1,MKNK2,EPHA8,ABL1,KIT,MAP4K4,EPHA5,TNIK,TEK,FLT3,FLT4,PDGFRB,MAPK12,NTRK1,MAPK13,BRAF,CIT,TIE1,CDK19,CDK8,EPHA3,KDR,FGFR1,CDK5,CDC42BPG,EPHA4,YES1,CDC42BPB,CD
C42BPA,PTK2,TNF,PTK2B,NTRK2,MKNK1,PRKCD,EPHB2,RET,PRKCB,FLT1,ANKK1,TTK,EPHA1,MAPK8,DDR2,LTK,LYN,EPHA6,MINK1,FGFR2,FGR,RAF1,FYN,FRK,EPHA7,ACVR1B,GSK3B,RIPK2,EPHA2,MAP3K20,BLK,DDR1,HCK,CDK7,CDK13,CAMK2B
,MUSK,NTRK3,TYRO3,NLK,MAPK1,EPHB3,EPHB4,FER,PDGFRA,STK10,MERTK,CSF1R,SLK,SRC,FGFR4,HTR2A,ABL2,MAPK15,MAP3K7,MARK2,CHEK2,TAB1,PRKD2,ABCB1,HSPB1}

> <pathway_gtopdb>
{Enzyme,"Secreted protein","Membrane receptor",Transporter,"Other cytosolic protein",Kinase,"Family A G protein-coupled receptor","Primary active transporter","Protein Kinase","Small molecule receptor
 (family A GPCR)","ATP-binding cassette","CMGC protein kinase group","TK protein kinase group","CAMK protein kinase group","STE protein kinase group","TKL protein kinase group","AGC protein kinase gro
up","Other protein kinase group","Monoamine receptor","ABCB subfamily","CMGC protein kinase MAPK family","Tyrosine protein kinase Src family","Tyrosine protein kinase EGFR family","Tyrosine protein ki
nase Eph family","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR family","STE protein kinase STE20 family","Tyrosine protein kinase Tie family"
,"Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Trk family","TKL protein kinase RAF family","AGC protein kinase DMPK family","CMGC protein kinase CDK family","Tyrosine protein kinase 
FGFR family","Tyrosine protein kinase Fak family","AGC protein kinase PKC family","Tyrosine protein kinase Ret family","TKL protein kinase RIPK family","Other protein kinase TTK family","Tyrosine prot
ein kinase DDR family","Tyrosine protein kinase Alk family","TKL protein kinase STKR family","CMGC protein kinase GSK family","TKL protein kinase MLK family","CAMK protein kinase CAMK2 family","Tyrosi
ne protein kinase Musk family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Fer family","Serotonin receptor","CAMK protein kinase CAMK1 family","CAMK protein kinase RAD53 family","CAM
K protein kinase PKD family","CMGC protein kinase p38 subfamily","CMGC protein kinase JNK subfamily","CAMK protein kinase MNK subfamily","STE protein kinase MSN subfamily","AGC protein kinase CRIK sub
family","CMGC protein kinase CDK8 subfamily","CMGC protein kinase CDK5 subfamily","AGC protein kinase GEK subfamily","AGC protein kinase PKC delta subfamily","AGC protein kinase PKC alpha subfamily","
Tyrosine protein kinase SrcA","TKL protein kinase STKR Type 1 subfamily","TKL protein kinase MLK subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase nmo subfamily","CMGC protein kinas
e ERK1","STE protein kinase SLK subfamily","TKL protein kinase TAK1 subfamily","CAMK protein kinase MARK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Kinases (EC 2.7.x.x)","Catalytic receptors","G protein-coupled receptors","ATP-binding cassette transporter family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Re
ceptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","5-Hydroxytryptamine 
receptors","ABCB subfamily","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","MAPK-Activated Protein Kinase (MAPKAPK) family","STE20 family","TKL: Tyrosine kinase-like","DMPK fa
mily","Cyclin-dependent kinase (CDK) family","Protein kinase C (PKC) family","Other protein kinases","Glycogen synthase kinase (GSK) family","CAMK2 family","CAMK-like (CAMKL) family","Protein kinase D
 (PKD) family","p38 subfamily","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","JNK subfamily","MKN subfamily","MSN subfamily","RAF family","Other DMPK family kinases","CDK8
 subfamily","CDK5 subfamily","GEK subfamily","Delta subfamily","Alpha subfamily","Receptor interacting protein kinase (RIPK) family","TTK family","Receptor serine/threonine kinase (RSTK) family","GSK 
subfamily","Mixed Lineage Kinase (MLK) family","CDK7 subfamily","CRK7 subfamily","nmo subfamily","ERK subfamily","SLK subfamily","Erk7 subfamily","MARK subfamily","CHK1 subfamily","Src family","Type I
 RTKs: ErbB (epidermal growth factor) receptor family","Type XIII RTKs: Ephrin receptor family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XII RTKs: TIE family of angiop
oietin receptors","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type V RTKs: FGF (fibroblast growth factor) receptor fami
ly","Fak family","Type XIV RTKs: RET","Type XVI RTKs: DDR (collagen receptor) family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type I receptor serine/threonine kinases","MLK s
ubfamily","Type IX RTKs: MuSK","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Fer family","TAK1 subfamily"}

> <pathway_reactome>
{"Immune System",Disease,"Signal Transduction","Developmental Biology","Cellular responses to external stimuli",Metabolism,"Gene expression (Transcription)","Cell Cycle","Extracellular matrix organiza
tion","Neuronal System",Hemostasis,"Innate Immune System","Infectious disease","Signaling by GPCR","Nervous system development","Diseases of signal transduction by growth factor receptors and second m
essengers","Cellular responses to stress","MAPK family signaling cascades","Signaling by Receptor Tyrosine Kinases","Intracellular signaling by second messengers","Signaling by Rho GTPases","Metabolis
m of lipids","RNA Polymerase II Transcription","Cytokine Signaling in Immune system",Mitotic,"Non-integrin membrane-ECM interactions","Signaling by NODAL","Transmission across Chemical Synapses","ECM 
proteoglycans","Signaling by WNT","Cell surface interactions at the vascular wall","Abacavir transport and metabolism","Signaling by Nuclear Receptors","Toll-like Receptor Cascades","HIV Infection","G
PCR downstream signalling","Axon guidance","Leishmania infection","Signaling by KIT in disease","Cellular Senescence","MAPK1/MAPK3 signaling","Signaling by Insulin receptor","Signaling by VEGF","PIP3 
activates AKT signaling","Signaling by NTRKs","RHO GTPase Effectors","Regulation of lipid metabolism by PPARalpha","Signaling by NOTCH1 in Cancer","Signaling by FGFR in disease","Generic Transcription
 Pathway","Signaling by Interleukins","Signaling by FGFR","DAG and IP3 signaling","M Phase","Regulation of signaling by NODAL","SARS-CoV Infections","Neurotransmitter receptors and postsynaptic signal
 transmission","Beta-catenin independent WNT signaling","Signaling by SCF-KIT","Signaling by PDGFR in disease","Neutrophil degranulation","GPCR ligand binding","Sphingolipid metabolism","Abacavir tran
smembrane transport","ESR-mediated signaling","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","G alpha (q) signalling events","EPH-Ephrin signaling","Parasite infection","Drug
 resistance of KIT mutants","Oxidative Stress Induced Senescence","RAF/MAP kinase cascade","Insulin receptor signalling cascade","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AK
T network","Signaling by NTRK1 (TRKA)","RHO GTPases activate CIT","PPARA activates gene expression","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","VEGFA-VEGFR2 Pathway","Signaling by FGFR1 in
 disease","Transcriptional Regulation by TP53","Leishmania parasite growth and survival","Interleukin-10 signaling","Interleukin-2 family signaling","Signaling by FGFR4","CaM pathway","RET signaling",
"Mitotic Prophase","Signaling by FGFR2 in disease","PTEN Regulation","SARS-CoV-1 Infection","Transcriptional regulation by RUNX1","HIV Life Cycle","Activation of NMDA receptors and postsynaptic events
","Signaling by NTRK3 (TRKC)","Ca2+ pathway","Drug resistance of PDGFR mutants","Transcriptional Regulation by VENTX","Class A/1 (Rhodopsin-like receptors)","Signaling by ROBO receptors","Toll Like Re
ceptor 4 (TLR4) Cascade","Sphingolipid de novo biosynthesis","Extra-nuclear estrogen signaling","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogene
sis","Gastrin-CREB signalling pathway via PKC and MAPK","EPHB-mediated forward signaling","EPHA-mediated growth cone collapse","Leishmania phagocytosis","Dasatinib-resistant KIT mutants","IRS-mediated
 signalling","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signalling to ERKs","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","VEG
FR2 mediated cell proliferation","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Anti-inflammatory response favouring Leishmania parasite infection","Interleukin-2 signaling","Activa
tion of TRKA receptors","Negative regulation of FGFR4 signaling","Calmodulin induced events","Nuclear Envelope Breakdown","FGFR2 mutant receptor activation","Negative regulation of MAPK pathway","Regu
lation of PTEN stability and activity","SARS-CoV-1 Genome Replication and Transcription","RUNX1 regulates transcription of genes involved in BCR signaling","Late Phase of HIV Life Cycle","TP53 Regulat
es Transcription of DNA Repair Genes","Post NMDA receptor activation events","Activated NTRK3 signals through PI3K","Imatinib-resistant PDGFR mutants","Downstream signaling of activated FGFR4","Amine 
ligand-binding receptors","Role of ABL in ROBO-SLIT signaling","MyD88-independent TLR4 cascade","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to cl
athrin adapters","EGFR Transactivation by Gastrin","FCGR3A-mediated phagocytosis","PI3K Cascade","Signalling to RAS","Prolonged ERK activation events","Signaling by activated point mutants of FGFR1","
Regulation of TP53 Activity through Phosphorylation","FCGR3A-mediated IL10 synthesis","NGF-independant TRKA activation","Spry regulation of FGF signaling","Depolymerisation of the Nuclear Lamina","Act
ivated point mutants of FGFR2","Negative feedback regulation of MAPK pathway","Nef and signal transduction","Replication of the SARS-CoV-1 genome","Transcription of the HIV genome","CREB1 phosphorylat
ion through NMDA receptor-mediated activation of RAS signaling","FRS-mediated FGFR4 signaling","Serotonin receptors","TRIF(TICAM1)-mediated TLR4 signaling","Regulation of TP53 Expression and Degradati
on","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","p38MAPK events","ARMS-mediated activation","activated TAK1 mediates p38 MAPK activation","HIV Transcripti
on Elongation","Ras activation upon Ca2+ influx through NMDA receptor","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Regulation of TP53 Degradation","Activation of the AP-1 family of
 transcription factors","Tat-mediated elongation of the HIV-1 transcript","ERK/MAPK targets","Formation of HIV-1 elongation complex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
{MAPK11,MAPK12,MAPK13,MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{Doramapimod,285983-48-4,285983484,"285983 48 4","BIRB 796",BIRB-796,BIRB796,"BIRB 796 (Doramapimod)",UNII-HO1A8B3YVV,UNIIHO1A8B3YVV,"UNII HO1A8B3YVV",HO1A8B3YVV,"BIRB-796 BS","BIRB796 BS","BIRB 796 B
S",CHEMBL103667,CHEBI:40953,C31,T6277,S1574}

> <pdid>
PD003343

> <targets>
{"p38 MAPK"}

> <classes>
{MAPK}

> <pubchem_cids>
{156422}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
    3.8912   -5.2570    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 S   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5923   -4.5039    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1065    0.0000    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6588   -2.9478    0.0000 N   0  0
   -5.1253   -4.3743    0.0000 C   0  0
   -6.5925   -4.6865    0.0000 C   0  0
   -7.0558   -6.1132    0.0000 C   0  0
   -6.0519   -7.2277    0.0000 C   0  0
   -6.5125   -8.6561    0.0000 C   0  0
   -5.5065   -9.7699    0.0000 N   0  0
   -5.9647  -11.1982    0.0000 C   0  0
   -4.9570  -12.3093    0.0000 C   0  0
   -3.4909  -11.9921    0.0000 C   0  0
   -3.0326  -10.5638    0.0000 C   0  0
   -4.0403   -9.4527    0.0000 C   0  0
   -4.5847   -6.9156    0.0000 C   0  0
   -4.1214   -5.4890    0.0000 C   0  0
   -2.1880   -3.7544    0.0000 C   0  0
   -2.6517   -5.1810    0.0000 C   0  0
   -1.6482   -6.2959    0.0000 C   0  0
   -0.1809   -5.9844    0.0000 C   0  0
    0.2829   -4.5579    0.0000 C   0  0
   -0.7206   -3.4429    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  2  0
  3  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 22  1  0
 20 28  1  0
 28 29  2  0
 29 17  1  0
 15 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
 14 36  1  0
 36 10  1  0
 36 37  2  0
 37  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28493

> <plate>
Kinase v5-2

> <well>
A20

> <supplier_cmpd_name>
Hesperadin

> <ctcr_id>
7147

> <supplier_cmpd_id>
S1529

> <smiles>
CC[S](=O)(=O)Nc1ccc2NC(=O)\C(=C(Nc3ccc(CN4CCCCC4)cc3)\c5ccccc5)c2c1

> <pd_targets>
{AURKB-A,PAK2,FES,SLC2A1,BRSK2,LMGT2,AURKB,RPS6KA4,AURKA,RPS6KA5,TYK2,HT1,PRKAA1,PTK2B,LTK,ROS1,PTK2,MELK}

> <pathway_gtopdb>
{Enzyme,Transporter,Kinase,"Electrochemical transporter","Protein Kinase","SLC superfamily of solute carriers","STE protein kinase group","TK protein kinase group","SLC02 family of hexose and sugar al
cohol transporters","CAMK protein kinase group","Other protein kinase group","AGC protein kinase group","STE protein kinase STE20 family","Tyrosine protein kinase Fer family","CAMK protein kinase CAMK
1 family","Other protein kinase AUR family","AGC protein kinase RSK family","Tyrosine protein kinase JakA family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Alk family","Tyrosine pr
otein kinase Sev family","STE protein kinase PAKA subfamily","CAMK protein kinase BRSK subfamily","AGC protein kinase MSK subfamily","CAMK protein kinase AMPK subfamily","CAMK protein kinase MELK subf
amily"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Kinases (EC 2.7.x.x)","Catalytic receptors","SLC superfamily of solute carriers","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases
","SLC2 family of hexose and sugar alcohol transporters","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC families","STE20 family","TK: Tyrosine kinase","Class I tra
nsporters","CAMK-like (CAMKL) family","Other protein kinases","RSK family","PAKA subfamily","Non-receptor tyrosine kinases (nRTKs)","BRSK subfamily","Aurora kinase (Aur) family","MSK subfamily","AMPK 
subfamily","Receptor tyrosine kinases (RTKs)","MELK subfamily","Fer family","Janus kinase (JakA) family","Fak family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XVII RTKs: 
ROS receptors"}

> <pathway_reactome>
{Disease,"Developmental Biology","Cell Cycle","Gene expression (Transcription)","Immune System","Infectious disease","Nervous system development","Disorders of transmembrane transporters",Mitotic,"RNA
 Polymerase II Transcription","Innate Immune System","Cytokine Signaling in Immune system","HIV Infection","Axon guidance","SLC transporter disorders","M Phase","Generic Transcription Pathway","Toll-l
ike Receptor Cascades","Interferon Signaling","Signaling by Interleukins","Leishmania infection","Host Interactions of HIV factors","Semaphorin interactions","Defective SLC2A1 causes GLUT1 deficiency 
syndrome 1 (GLUT1DS1)","Mitotic Metaphase and Anaphase","L1CAM interactions","Transcriptional Regulation by TP53","Toll Like Receptor 5 (TLR5) Cascade","Interferon alpha/beta signaling","Interleukin-2
 family signaling","Parasite infection","The role of Nef in HIV-1 replication and disease pathogenesis","CRMPs in Sema3A signaling","Mitotic Anaphase","Recycling pathway of L1","Regulation of TP53 Act
ivity","MyD88 cascade initiated on plasma membrane","Regulation of IFNA signaling","Interleukin-2 signaling","Leishmania phagocytosis","Nef and signal transduction","Separation of Sister Chromatids","
Regulation of TP53 Activity through Phosphorylation","MAP kinase activation","FCGR3A-mediated phagocytosis","MAPK targets/ Nuclear events mediated by MAP kinases","CREB phosphorylation"}

> <broad_targets>
{AURKB}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{Hesperadin,S1529}

> <pdid>
PD010990

> <targets>
{Aurora,"Aurora Kinase"}

> <classes>
{}

> <pubchem_cids>
{10142586}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 C   0  0
    2.5973   -1.5031    0.0000 S   0  0
    2.5951   -3.0031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 N   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.8193    4.6606    0.0000 C   0  0
   -4.0353    5.9336    0.0000 C   0  0
   -4.7489    7.2530    0.0000 C   0  0
   -6.2483    7.2947    0.0000 C   0  0
   -6.9619    8.6141    0.0000 F   0  0
   -7.0341    6.0170    0.0000 C   0  0
   -6.3205    4.6976    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -6.4469    1.8311    0.0000 C   0  0
   -7.4153    2.9701    0.0000 C   0  0
   -8.8906    2.6991    0.0000 C   0  0
   -9.3937    1.2860    0.0000 N   0  0
   -8.4213    0.1438    0.0000 C   0  0
   -6.9460    0.4147    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 13  1  0
 12 20  2  0
 20 21  1  0
 21 10  2  0
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28494

> <plate>
Kinase v5-2

> <well>
A22

> <supplier_cmpd_name>
SB 203580

> <ctcr_id>
4877

> <supplier_cmpd_id>
S1076

> <smiles>
C[S](=O)c1ccc(cc1)c2[nH]c(c3ccc(F)cc3)c(n2)c4ccncc4

> <pd_targets>
{TNNI3K,GSK3B,RPS6KA6,MAPK14,MAPK11,MAPK12,MAPK13,TGFBR1,ACVR1B,LCK,TYK2,NLK,KMT2A,MEN1,HSD17B10,CSNK1A1,RAF1,MAPK9,EGFR,CYP2D6,TTK,RIPK2,GAK,CSNK1D,BRAF,MAP2K1,MAP2K2,CYP1A2,CYP3A4,HTR4,FRK,MAPK10,ST
K36,PTK6,SLK,TNIK,CDC42BPG,CDPK1,TXK,CDC42BPB,MAPK-1,RPS6KA1,EPHA6,SRC,MAPK1,STK32B,LEF,ERBB4,ALDH1A1,EPHB2,CSNK1E,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3,CYP2C9,CYP2C19,MAPK
8,MAP4K4,MET,CIT,COQ8B,TGFBR2,PTGS1,ABL1,SIK2,KDM4E,SIK3,STK32A,ALOX5,TEK,DDR2,P2RX7,DDR1,ALOX15,HPGD,MAP2K5,FLT4,MAP3K20,CSNK1A1L,CDC42BPA,GCGR,PRKACA,PRKACB,PRKACG,TSHR,MINK1,BMPR1B,PIP5K1C,PRKD2,EP
HB6,TBXAS1,PDE5A,ADORA1,ADORA2A,CHRM1,ERBB2,TYR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Membrane receptor","Ion channel","Unclassified protein",Kinase,Reader,Oxidoreductase,"Cytochrome P450","Family A G protein-coupled receptor",Protease,Eraser,"Ligand-gat
ed ion channel","Family B G protein-coupled receptor",Transferase,Phosphodiesterase,"Protein Kinase",Bromodomain,"Cytochrome P450 family 2","Cytochrome P450 family 1","Cytochrome P450 family 3","Small
 molecule receptor (family A GPCR)","Metallo protease","Lysine demethylase","P2X receptor","Peptide receptor (family B GPCR)","Peptide receptor (family A GPCR)","Cytochrome P450 family 5","Phosphodies
terase 5","TKL protein kinase group","CMGC protein kinase group","AGC protein kinase group","TK protein kinase group","CK1 protein kinase group","Cytochrome P450 family 2D","Other protein kinase group
","STE protein kinase group","Cytochrome P450 family 1A","Cytochrome P450 family 3A","Monoamine receptor","Metallo protease MAE clan","Cytochrome P450 family 2C","Atypical protein kinase group","CAMK 
protein kinase group","Jumonji domain-containing","Glucagon-like receptor","Glycohormone receptor","Cytochrome P450 family 5A","Phosphodiesterase 5A","Nucleotide-like receptor (family A GPCR)","TKL pr
otein kinase MLK family","CMGC protein kinase GSK family","AGC protein kinase RSK family","CMGC protein kinase MAPK family","TKL protein kinase STKR family","Tyrosine protein kinase Src family","Tyros
ine protein kinase JakA family","CK1 protein kinase CK1 family","TKL protein kinase RAF family","Tyrosine protein kinase EGFR family","Cytochrome P450 2D6","Other protein kinase TTK family","TKL prote
in kinase RIPK family","Other protein kinase NAK family","STE protein kinase STE7 family","Cytochrome P450 1A1","Cytochrome P450 3A4","Serotonin receptor","Other protein kinase ULK family","STE protei
n kinase STE20 family","AGC protein kinase DMPK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Eph family","AGC protein kinase YANK family","Metallo protease M34 family","AGC pr
otein kinase PKC family","Cytochrome P450 2C9","Cytochrome P450 2C19","Tyrosine protein kinase Met family","Atypical protein kinase ABC1 family","Tyrosine protein kinase Abl family","CAMK protein kina
se CAMK1 family","Tyrosine protein kinase Tie family","Tyrosine protein kinase DDR family","Tyrosine protein kinase VEGFR family","Glucagon receptor","AGC protein kinase PKA family","CAMK protein kina
se PKD family","Cytochrome P450 5A1","Adenosine receptor","Acetylcholine receptor","TKL protein kinase HH498 subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase p38 subfamily","TKL prot
ein kinase STKR Type 1 subfamily","CMGC protein kinase nmo subfamily","CMGC protein kinase JNK subfamily","STE protein kinase SLK subfamily","STE protein kinase MSN subfamily","AGC protein kinase GEK 
subfamily","CMGC protein kinase ERK1","AGC protein kinase PKC alpha subfamily","AGC protein kinase CRIK subfamily","Atypical protein kinase ABC1-A subfamily","TKL protein kinase STKR Type 2 subfamily"
,"CAMK protein kinase QIK subfamily","TKL protein kinase MLK subfamily","CK1 protein kinase CK1-a"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","G protein-coupled receptors","Eicosanoid turnover","Chromatin modifying enzymes","Ligand-gated ion cha
nnels","Cyclic nucleotide turnover/signalling","1.-.-.- Oxidoreductases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase
 1","CYP2 family: drug metabolising subset","CYP1 family","CYP3 family","5-Hydroxytryptamine receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Atypical,Cyclooxygenase,"CA
MK: Calcium/calmodulin-dependent protein kinases","1.14.11.- Histone demethylases",Lipoxygenases,"P2X receptors","Prostaglandin synthases","Glucagon receptor family","Glycoprotein hormone receptors","
Lipid modifying kinases",CYP5,"CYP7 and CYP8 families",Phosphodiesterases,3',"5'-cyclic nucleotide (PDEs)","Adenosine receptors","Acetylcholine receptors (muscarinic)","TKL: Tyrosine kinase-like","Gly
cogen synthase kinase (GSK) family","RSK family","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","Other protein kinases","STE20 family","DMPK fam
ily","YANK family","STE7 family","ABC1 family","CAMK-like (CAMKL) family","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","Protein kinase D (PKD) family","Mixed Lineage Kinas
e (MLK) family","GSK subfamily","RSK subfamily","p38 subfamily","Receptor serine/threonine kinase (RSTK) family","Non-receptor tyrosine kinases (nRTKs)","nmo subfamily","RAF family","JNK subfamily","R
eceptor tyrosine kinases (RTKs)","TTK family","Receptor interacting protein kinase (RIPK) family","Numb-associated kinase (NAK) family","Unc-51-like kinase (ULK) family","SLK subfamily","MSN subfamily
","GEK subfamily","ERK subfamily","Other DMPK family kinases","ABC1-B subfamily","QIK subfamily","HH498 subfamily","Type I receptor serine/threonine kinases","Src family","Janus kinase (JakA) family",
"Type I RTKs: ErbB (epidermal growth factor) receptor family","Tec family","Type XIII RTKs: Ephrin receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type II receptor seri
ne/threonine kinases","Abl family","Type XII RTKs: TIE family of angiopoietin receptors","Type XVI RTKs: DDR (collagen receptor) family","Type IV RTKs: VEGF (vascular endothelial growth factor) recept
or family","MLK subfamily"}

> <pathway_reactome>
{Disease,"Neuronal System","Immune System","Developmental Biology","Signal Transduction",Metabolism,"Vesicle-mediated transport","Cell Cycle","Cellular responses to external stimuli","Extracellular ma
trix organization",Hemostasis,"Infectious disease","Transmission across Chemical Synapses","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Si
gnaling by NODAL","Cytokine Signaling in Immune system","Signaling by WNT","Metabolism of amino acids and derivatives","MAPK family signaling cascades","Signaling by GPCR","Biological oxidations","Sig
naling by Receptor Tyrosine Kinases","Membrane Trafficking",Mitotic,"Metabolism of lipids","Intracellular signaling by second messengers","Cellular responses to stress","Nervous system development","S
ignaling by Rho GTPases","Non-integrin membrane-ECM interactions","Signaling by TGFB family members","Platelet homeostasis","SARS-CoV Infections","Neurotransmitter receptors and postsynaptic signal tr
ansmission","Toll-like Receptor Cascades","Signaling by TGF-beta Receptor Complex in Cancer","Regulation of signaling by NODAL","HIV Infection","Interferon Signaling","Beta-catenin independent WNT sig
naling","Branched-chain amino acid catabolism","Signaling by WNT in cancer","MAPK1/MAPK3 signaling","GPCR downstream signalling","Phase I - Functionalization of compounds","Signaling by NTRKs","trans-
Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania infection","PIP3 activates AKT signaling","Mitotic G1 phase and G1/S tra
nsition","Cellular Senescence","Fc epsilon receptor (FCERI) signaling","Axon guidance","Uptake and actions of bacterial toxins","RHO GTPase Effectors","Fatty acid metabolism","Signaling by VEGF","Sign
aling by BMP","Sphingolipid metabolism","Nitric oxide stimulates guanylate cyclase","GPCR ligand binding","Melanin biosynthesis","SARS-CoV-1 Infection","Activation of NMDA receptors and postsynaptic e
vents","Toll Like Receptor 5 (TLR5) Cascade","Loss of Function of SMAD2/3 in Cancer","Host Interactions of HIV factors","Interferon alpha/beta signaling","Ca2+ pathway","Signaling by AMER1 mutants","R
AF/MAP kinase cascade","G alpha (q) signalling events","Cytochrome P450 - arranged by substrate type","Signaling by NTRK1 (TRKA)","Golgi Associated Vesicle Biogenesis","G2/M Transition","Biosynthesis 
of DHA-derived SPMs","Leishmania parasite growth and survival","PTEN Regulation","G1 Phase","Oxidative Stress Induced Senescence","FCERI mediated Ca+2 mobilization","EPH-Ephrin signaling","Uptake and 
function of anthrax toxins","Ethanol oxidation","Semaphorin interactions","RHO GTPases activate CIT","Arachidonic acid metabolism","Parasite infection","Biosynthesis of DPA-derived SPMs","Cell recruit
ment (pro-inflammatory response)","VEGF ligand-receptor interactions","Sphingolipid de novo biosynthesis","cGMP effects","Class A/1 (Rhodopsin-like receptors)","SARS-CoV-1 Genome Replication and Trans
cription","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","SMAD2/3 Phosphorylation Motif Mutants in Cancer","The role of Nef in HIV-1 replication and disease pathog
enesis","Regulation of IFNA signaling","Truncations of AMER1 destabilize the destruction complex","Negative regulation of MAPK pathway","Gastrin-CREB signalling pathway via PKC and MAPK",Xenobiotics,"
Signalling to ERKs","Centrosome maturation","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of PTEN stability and activity","Cyclin D associ
ated events in G1","EPHA-mediated growth cone collapse","EPHB-mediated forward signaling","Sema4D in semaphorin signaling","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)","Leishmania phagocyt
osis","Biosynthesis of DPAn-3 SPMs","Purinergic signaling in leishmaniasis infection","Biosynthesis of D-series resolvins","Signalling to ERK5","VEGF binds to VEGFR leading to receptor dimerization","
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion",Eicosanoids,"Nucleotide-like (purinergic) receptors","Amine ligand-binding receptors","Replication of the SARS-CoV-1 genome","CREB1 p
hosphorylation through NMDA receptor-mediated activation of RAS signaling","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Neg
ative feedback regulation of MAPK pathway","EGFR Transactivation by Gastrin","CYP2E1 reactions","Signalling to RAS","Loss of proteins required for interphase microtubule organization from the centroso
me","Prolonged ERK activation events","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of maresin-like SPMs","ADORA2B mediated anti-inflammatory cytokines production","
Long-term potentiation","Sema4D mediated inhibition of cell attachment and migration","FCGR3A-mediated phagocytosis","Biosynthesis of DPAn-3-derived 13-series resolvins","Biosynthesis of DPAn-3-derive
d protectins and resolvins","Adenosine P1 receptors","Muscarinic acetylcholine receptors","Sema4D induced cell migration and growth-cone collapse","RSK activation","MAPK targets/ Nuclear events mediat
ed by MAP kinases","Nef Mediated CD4 Down-regulation","p38MAPK events","activated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","ARMS-mediated activation","Frs2-mediated ac
tivation","Activation of the AP-1 family of transcription factors","CREB phosphorylation","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,ALOX5,CHEK1,CYP2D6,CYP3A4,GAK,GSK3B,LCK,MAPK1,MAPK10,MAPK11,MAPK12,MAPK14,MAPK8,MAPK9,PRKCA,RAF1,RIPK2,ROCK1,RPS6KB1,SGK1,SRC,TNF}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{B20358,152121-47-6,152121476,"SB 203580",SB-203580,SB203580,4-(4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl)pyridine,4(4(4fluorophenyl)2(4methylsulfinylphenyl)1Himidazol5yl)pyridine
,4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole,4(4Fluorophenyl)2(4methylsulfinylphenyl)5(4pyridyl)1Himidazole,"RWJ 64809",4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)ph,4(4Fluor
ophenyl)2(4(methylsulfinyl)ph,"EMD 559389",S1076,EI-286,559389}

> <pdid>
PD004782

> <targets>
{"p38 MAPK","P38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{176155}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    3.9051    0.7424    0.0000 N   0  0
    3.8999   -0.7576    0.0000 C   0  0
    5.1965   -1.5117    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 C   0  0
   -3.4642    1.0046    0.0000 N   0  0
   -2.5951    3.0031    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -6.4924   -3.7566    0.0000 F   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -3.8990   -0.7525    0.0000 C   0  0
   -3.9007    0.2475    0.0000 F   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    5.1932   -3.0130    0.0000 F   0  0
    3.8864   -5.2585    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
   -0.0030   -2.9951    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
  9 11  2  0
  8 12  1  0
 12 13  2  0
 13  5  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 14  1  0
 20 21  1  0
  4 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 22  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28495

> <plate>
Kinase v5-2

> <well>
C04

> <supplier_cmpd_name>
VX-702

> <ctcr_id>
2192

> <supplier_cmpd_id>
S6005

> <smiles>
NC(=O)N(c1ccc(C(N)=O)c(n1)c2ccc(F)cc2F)c3c(F)cccc3F

> <pd_targets>
{ACVR2B,PRKD2,MAPK10,ROCK1,MAPK11,MAPK14,MAPK9,PI4KB,PRKD3,NLK}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","TKL protein kinase group","CAMK protein kinase group","CMGC protein kinase group","AGC protein kinase group","TKL protein kinase STKR family","CAMK protein
 kinase PKD family","CMGC protein kinase MAPK family","AGC protein kinase DMPK family","TKL protein kinase STKR Type 2 subfamily","CMGC protein kinase JNK subfamily","AGC protein kinase ROCK subfamily
","CMGC protein kinase p38 subfamily","CMGC protein kinase nmo subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing
 PKA",PKG,"PKC families","Lipid modifying kinases","TKL: Tyrosine kinase-like","Protein kinase D (PKD) family","Mitogen-activated protein kinases (MAP kinases)","DMPK family","1-phosphatidylinositol 4
-kinase family","Receptor serine/threonine kinase (RSTK) family","JNK subfamily","Rho kinase","p38 subfamily","nmo subfamily","Type II receptor serine/threonine kinases"}

> <pathway_reactome>
{"Developmental Biology",Metabolism,"Immune System","Signal Transduction","Signaling by NODAL","Metabolism of lipids","Innate Immune System","Nervous system development","Signaling by WNT","Regulation
 of signaling by NODAL","Sphingolipid metabolism","Toll-like Receptor Cascades","Axon guidance","Phospholipid metabolism","Beta-catenin independent WNT signaling","Sphingolipid de novo biosynthesis","
Toll Like Receptor 5 (TLR5) Cascade","Semaphorin interactions","PI Metabolism","Ca2+ pathway","MyD88 cascade initiated on plasma membrane","Sema4D in semaphorin signaling","Synthesis of PIPs at the Go
lgi membrane","MAP kinase activation","Sema4D induced cell migration and growth-cone collapse","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription fa
ctors"}

> <broad_targets>
{IL1B,IL6,MAPK11,MAPK12,MAPK14,TNF}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{X70,VX-702,VX702,745833-23-2,745833232,479543-46-9,479543469,"VX 702","2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide","2(2,4difluorophenyl)6(1(2,6difluorophenyl)ureido)nicotinam
ide",UNII-527E7SK68P,UNII527E7SK68P,CHEMBL1090090,527E7SK68P,"745833-23-2 (or 479543-46-9)","745833232 (or 479543469)",C19H12F4N4O2,2-(2,2(2,4-Difluorophenyl)-6-(1-(2,4Difluorophenyl)6(1(2,6-difluorop
heny,6difluoropheny,T2513,S6005}

> <pdid>
PD010657

> <targets>
{"p38 MAPK","P38 MAPK",Autophagy}

> <classes>
{Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{10341154}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    2.5796   -7.5040    0.0000 F   0  0
    2.5847   -6.0040    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.8971    3.7500    0.0000 O   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.8978    0.7496    0.0000 C   0  0
   -5.1981    1.4975    0.0000 C   0  0
   -5.2005    2.9975    0.0000 Cl  0  0
   -6.4959    0.7454    0.0000 C   0  0
   -6.4936   -0.7546    0.0000 C   0  0
   -5.1933   -1.5025    0.0000 C   0  0
   -3.8955   -0.7505    0.0000 C   0  0
   -2.5953   -1.4984    0.0000 Cl  0  0
    3.8915   -3.7585    0.0000 C   0  0
    5.1932   -3.0130    0.0000 F   0  0
    3.8864   -5.2585    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  3
 15  9  1  0
 15 16  1  0
 16 17  2  3
 17  7  1  0
 14 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 18  1  0
 24 25  1  0
  5 26  1  0
 26 27  1  0
 26 28  2  0
 28  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28496

> <plate>
Kinase v5-2

> <well>
C06

> <supplier_cmpd_name>
VX-745

> <ctcr_id>
5006

> <supplier_cmpd_id>
S1458

> <smiles>
Fc1ccc(SC2=NN3C=NC(=O)C(=C3C=C2)c4c(Cl)cccc4Cl)c(F)c1

> <pd_targets>
{MAPK14,EPHB4,ABL1,EPHA1,PDGFRB,MAPK11,CSF1R,LCK,LYN,ABL2,EPHA2,SRC,MAPK12,MAPK13,FYN,FGR,DDR1,EPHB1,BLK,EPHA8,YES1,HCK,EPHA5,FRK,PDGFRA,HTR2A,ROS1,EPHA4,SLC6A3,SLC6A2,ADRA2B,ADRA2A,ADORA3}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor",Transporter,Kinase,"Family A G protein-coupled receptor","Electrochemical transporter","Protein Kinase","Small molecule receptor (family A GPCR)","SLC superfamily of solute
 carriers","CMGC protein kinase group","TK protein kinase group","Monoamine receptor","SLC06 neurotransmitter transporter family","Nucleotide-like receptor (family A GPCR)","CMGC protein kinase MAPK f
amily","Tyrosine protein kinase Eph family","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase DDR family","Serot
onin receptor","Tyrosine protein kinase Sev family","Adrenergic receptor","Adenosine receptor","CMGC protein kinase p38 subfamily","Tyrosine protein kinase SrcA"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Kinases (EC 2.7.x.x)","Catalytic receptors","G protein-coupled receptors","SLC superfamily of solute carriers","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Recepto
r kinases","5-Hydroxytryptamine receptors","SLC6 neurotransmitter transporter family",Adrenoceptors,"Adenosine receptors","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","Monoa
mine transporter subfamily","p38 subfamily","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type XIII RTKs: Ephrin receptor family","Abl family","Type III RTKs: PDGFR",CSFR
,Kit,"FLT3 receptor family","Src family","Type XVI RTKs: DDR (collagen receptor) family","Type XVII RTKs: ROS receptors"}

> <pathway_reactome>
{"Immune System","Developmental Biology",Disease,"Signal Transduction","Gene expression (Transcription)","Extracellular matrix organization","Innate Immune System","Nervous system development","Infect
ious disease","Intracellular signaling by second messengers","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Non-integrin membrane-ECM interactions","Diseases of signal tra
nsduction by growth factor receptors and second messengers","Signaling by GPCR","Disorders of transmembrane transporters","Toll-like Receptor Cascades","Axon guidance","Leishmania infection","PIP3 act
ivates AKT signaling","Generic Transcription Pathway","HIV Infection","Signaling by NTRKs","Signaling by PDGFR in disease","GPCR ligand binding","SLC transporter disorders","Toll Like Receptor 5 (TLR5
) Cascade","EPH-Ephrin signaling","Parasite infection","Negative regulation of the PI3K/AKT network","Transcriptional Regulation by VENTX","Host Interactions of HIV factors","Leishmania parasite growt
h and survival","Signaling by ROBO receptors","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX1","PTEN Regulation","Drug resistance of PDGFR mutants","Class A/1 (Rhodopsin-like receptor
s)","Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)","Defective SLC6A2 causes orthostatic intolerance (OI)","MyD88 cascade initiated on plasma membrane","EPHB-mediated forward signali
ng","Leishmania phagocytosis","EPHA-mediated growth cone collapse",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","The role of Nef in HIV-1 replication and disease pathogenesis","Anti-inflammatory r
esponse favouring Leishmania parasite infection","Role of ABL in ROBO-SLIT signaling","Signalling to ERKs","RUNX1 regulates transcription of genes involved in BCR signaling","Regulation of PTEN stabil
ity and activity","Imatinib-resistant PDGFR mutants","Amine ligand-binding receptors","Nucleotide-like (purinergic) receptors","MAP kinase activation","FCGR3A-mediated phagocytosis","Nef-mediates down
 modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated IL10 synthesis","Signalling to RAS","Nef and signal transduction","Serotonin receptors",Adrenoceptors,"A
denosine P1 receptors","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","p38MAPK events","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK11,MAPK12,MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{209410-46-8,209410468,VX-745,VX745,Neflamapimod,"VX 745",VRT-031745,VRT031745,C19H9Cl2F2N3OS,UNII-TYL52QM320,UNIITYL52QM320,TYL52QM320,CHEBI:90528,"Neflamapimod (USAN)",VD-31745,VD31745,"VD-31,745","
VD31,745",hexadecylacrylate,"zlchem 1139",Kinome_3767,Kinome3767,Kinome-3767,"Kinome 3767",PubChem17468,cc-466,cc466,MLS006010281,SCHEMBL156367,CHE,T6089,S1458}

> <pdid>
PD003254

> <targets>
{"p38 MAPK",Autophagy}

> <classes>
{MAPK,Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{3038525}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    6.9144   -6.1912    0.0000 O   0  0
    6.3037   -4.8211    0.0000 C   0  0
    4.8111   -4.6641    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    2.7343   -2.9815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.1905    2.6376    0.0000 N   0  0
   -4.6581    2.9476    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 N   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 10  1  0
 14 15  2  3
 15 16  1  0
 11 17  2  0
 17  7  1  0
  6 18  1  0
 18 19  2  0
 19  4  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28497

> <plate>
Kinase v5-2

> <well>
C08

> <supplier_cmpd_name>
GDC-0879

> <ctcr_id>
1998

> <supplier_cmpd_id>
S1104

> <smiles>
OCCn1cc(c2ccc3c(CCC3=NO)c2)c(n1)c4ccncc4

> <pd_targets>
{BRAF,TGFBR1,TNIK,MAP4K4,STK10,CSNK1E,JAK1,ABL1,CIT,MAP3K19,MAP2K5,CSNK1D,ACVR1B,RAF1,MINK1,SLK,MAPK10,RIPK2,RIOK2,BMPR1B,ERBB3,MAPK1,MAPK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","STE protein kinase group","CK1 protein kinase group","TK protein kinase group","AGC protein kinase group","CMGC protein kinase group","Atypi
cal protein kinase group","TKL protein kinase RAF family","TKL protein kinase STKR family","STE protein kinase STE20 family","CK1 protein kinase CK1 family","Tyrosine protein kinase JakA family","Tyro
sine protein kinase Abl family","AGC protein kinase DMPK family","STE protein kinase STE11 family","STE protein kinase STE7 family","CMGC protein kinase MAPK family","TKL protein kinase RIPK family","
Atypical protein kinase RIO family","Tyrosine protein kinase EGFR family","TKL protein kinase STKR Type 1 subfamily","STE protein kinase MSN subfamily","STE protein kinase SLK subfamily","AGC protein 
kinase CRIK subfamily","CMGC protein kinase JNK subfamily","Atypical protein kinase RIO2 subfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","AGC: Containing PKA",PKG
,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"TKL: Tyrosine kinase-like","STE20 family","Casein kinase 1 (CK1) family","TK: Tyrosine kinase","DMPK family","STE7 family","Mi
togen-activated protein kinases (MAP kinases)","RIO family","RAF family","Receptor serine/threonine kinase (RSTK) family","MSN subfamily","SLK subfamily","Non-receptor tyrosine kinases (nRTKs)","Other
 DMPK family kinases","STE20 subfamily","JNK subfamily","Receptor interacting protein kinase (RIPK) family","RIO2 subfamily","Receptor tyrosine kinases (RTKs)","Type I receptor serine/threonine kinase
s","Janus kinase (JakA) family","Abl family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Cellular responses to external stimuli","Immune System","Cell Cycle","Developmental Biology","Metabolism of RNA","Signaling by Receptor Tyrosine Kinases","Diseases of s
ignal transduction by growth factor receptors and second messengers","Cellular responses to stress","Innate Immune System",Mitotic,"Cytokine Signaling in Immune system","Infectious disease","Signaling
 by Rho GTPases","Signaling by NODAL","MAPK family signaling cascades","rRNA processing","Signaling by TGFB family members","Intracellular signaling by second messengers","Signaling by NTRKs","Signali
ng by TGF-beta Receptor Complex in Cancer","Cellular Senescence","Neutrophil degranulation","Mitotic G2-G2/M phases","Interferon Signaling","Leishmania infection","RHO GTPase Effectors","Regulation of
 signaling by NODAL","MAPK1/MAPK3 signaling","Toll-like Receptor Cascades","rRNA processing in the nucleus and cytosol","Signaling by BMP","PIP3 activates AKT signaling","Signaling by NTRK1 (TRKA)","L
oss of Function of SMAD2/3 in Cancer","Oxidative Stress Induced Senescence","G2/M Transition","Antiviral mechanism by IFN-stimulated genes","Parasite infection","RHO GTPases activate CIT","RAF/MAP kin
ase cascade","Toll Like Receptor 5 (TLR5) Cascade","Major pathway of rRNA processing in the nucleolus and cytosol","Negative regulation of the PI3K/AKT network","Signalling to ERKs","SMAD2/3 Phosphory
lation Motif Mutants in Cancer","Centrosome maturation","ISG15 antiviral mechanism","Leishmania phagocytosis","Signalling to ERK5","Negative regulation of MAPK pathway","MyD88 cascade initiated on pla
sma membrane",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Prolonged ERK activation events","Loss of proteins required for interphase microtubule organization from the centrosome","FCGR3A-mediate
d phagocytosis","Negative feedback regulation of MAPK pathway","MAP kinase activation","ARMS-mediated activation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP k
inases","activated TAK1 mediates p38 MAPK activation","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{BRAF}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{DC087,GDC-0879,GDC0879,905281-76-7,905281767,"GDC 0879",CHEMBL2139930,HMS3295O17,HMS3654K21,BCP02896,AKOS030231604,NCGC00263179-01,NCGC0026317901,SW219204-1,SW2192041,Q27163282,T6320,S1104}

> <pdid>
PD003230

> <targets>
{B-Raf,Raf}

> <classes>
{MAPK}

> <pubchem_cids>
{57519545}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    7.7962   -1.5128    0.0000 C   0  0
    6.4994   -0.7589    0.0000 O   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    3.9015    0.7475    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  7 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28498

> <plate>
Kinase v5-2

> <well>
C10

> <supplier_cmpd_name>
PD98059

> <ctcr_id>
4311

> <supplier_cmpd_id>
S1177

> <smiles>
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

> <pd_targets>
{HPGD,CYP3A4,CYP1A2,MAPK1,PTGS1,SMN1,TSHR,MAPT,CYP2C19,PYK,MAP2K1,ALDH1A1,PMP22,PKM,ALOX15,THPO,TP53,CYP2D6,CYP2C9,KMT2A,MEN1,LEF,BLM,NPC1,CHRM1,RAF1,RAB9A,MAP2K2,GMNN,RORC}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Membrane receptor","Other cytosolic protein","Unclassified protein","Transcription factor",Transporter,"Cytochrome P450",Kinase,Oxidoreductase,Reader,"Family A G protei
n-coupled receptor",Transferase,Protease,Hydrolase,"Nuclear receptor","Cytochrome P450 family 3","Cytochrome P450 family 1","Protein Kinase","Methyl-lysine/arginine binding protein","Peptide receptor 
(family A GPCR)","Cytochrome P450 family 2",Bromodomain,"Metallo protease","Small molecule receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3A","Cytochrome P450
 family 1A","CMGC protein kinase group","Tudor domain","Glycohormone receptor","Cytochrome P450 family 2C","STE protein kinase group","Cytochrome P450 family 2D","Metallo protease MAE clan","Monoamine
 receptor","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 3A4","Cytochrome P450 1A1","CMGC protein kinase MAPK family","Cytochrome P450 2C19","STE protein kinase STE7 family","Cytochr
ome P450 2D6","Cytochrome P450 2C9","Metallo protease M34 family","Acetylcholine receptor","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Eicosanoid turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","G protein-coupled receptors","2.7.1.40 Pyruvate kinases","SLC superfamily of solute carriers","Nuclear h
ormone receptors","Prostaglandin synthases","CYP3 family","CYP1 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Cyclooxygenase,"Glycoprotein hormone receptors","CYP2 family: drug metabolising 
subset","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Lipoxygenases,"SLC65 NPC-type cholesterol transporters","Acetylcholine receptors (muscarinic)","1F. Retinoic acid-related o
rphans","Mitogen-activated protein kinases (MAP kinases)","STE7 family","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Immune System","Metabolism of RNA",Disease,"Neuronal System","Signal Transduction","Developmental Biology",Hemostasis,"Cell Cycle","DNA Repair","Transport of small molecules","Gene expres
sion (Transcription)","Metabolism of lipids","Biological oxidations","Innate Immune System","Metabolism of non-coding RNA","Infectious disease","Transmission across Chemical Synapses","Signaling by Re
ceptor Tyrosine Kinases","Nervous system development","Metabolism of carbohydrates","Platelet activation","signaling and aggregation","Cell Cycle Checkpoints","DNA Double-Strand Break Repair","Plasma 
lipoprotein assembly",remodeling,"and clearance","Signaling by GPCR","Signaling by Rho GTPases",Mitotic,"RNA Polymerase II Transcription","Biosynthesis of specialized proresolving mediators (SPMs)","P
hase I - Functionalization of compounds","Toll-like Receptor Cascades","Fatty acid metabolism","snRNP Assembly","Leishmania infection","Neurotransmitter receptors and postsynaptic signal transmission"
,"Signaling by NTRKs","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Glucose metabolism","Platelet Aggregation (Plug Formation)","G1/S DNA Damage Checkpoints","Uptake and actions of
 bacterial toxins","Homology Directed Repair","Plasma lipoprotein clearance","GPCR ligand binding","Rho GTPase cycle","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Biosynthes
is of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Toll Like Receptor 5 (TLR5) Cascade","Arachidonic acid metabolism","Leishmania parasite growth and survival","Activation of NMDA
 receptors and postsynaptic events","Signaling by NTRK1 (TRKA)","Ethanol oxidation",Glycolysis,"Biosynthesis of DPA-derived SPMs","p53-Dependent G1/S DNA damage checkpoint","Uptake and function of ant
hrax toxins","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","LDL clearance","Class A/1 (Rhodopsin-like receptors)","RHOBTB GTPase Cycle","G1/S Transition","Transcription
al regulation by RUNX3","Biosynthesis of D-series resolvins","Biosynthesis of maresins",Xenobiotics,"MyD88 cascade initiated on plasma membrane","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
","Anti-inflammatory response favouring Leishmania parasite infection","Post NMDA receptor activation events","Signalling to ERKs","Biosynthesis of DPAn-3 SPMs","p53-Dependent G1 DNA Damage Response",
"HDR through Homologous Recombination (HRR)","Amine ligand-binding receptors","RHOBTB3 ATPase cycle","Activation of the pre-replicative complex","RUNX3 Regulates Immune Response and Cell Migration","B
iosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP kinase activation","ADORA2B mediated anti-inflammatory cytokines production","Activation of AM
PK downstream of NMDARs","CYP2E1 reactions","Prolonged ERK activation events","Biosynthesis of DPAn-3-derived protectins and resolvins","Stabilization of p53","Homologous DNA Pairing and Strand Exchan
ge","Muscarinic acetylcholine receptors","MAPK targets/ Nuclear events mediated by MAP kinases","Frs2-mediated activation","Autodegradation of the E3 ubiquitin ligase COP1","Presynaptic phase of homol
ogous DNA pairing and strand exchange","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,CHEK1,GSK3B,LCK,MAP2K1,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,RAF1,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{167869-21-8,167869218,PD98059,"PD 98059",2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one,2(2amino3methoxyphenyl)4Hchromen4one,PD-98059,"PD 98,059",2-(2-amino-3-methoxyphenyl)chromen-4-one,2(2amino3metho
xyphenyl)chromen4one,2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one,2(2Amino3methoxyphenyl)4H1benzopyran4one,2'-AMINO-3'-METHOXYFLAVONE,2'AMINO3'METHOXYFLAVONE,PD-098059,PD098059,4H-1-Benzopyran-4-
one,4H1Benzopyran4one,T2623,"EMD 513000",S1177,1213,EI-360,513000}

> <pdid>
PD002681

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{4713}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
    7.0503  -11.0244    0.0000 C   0  0
    5.5827  -10.7143    0.0000 C   0  0
    5.1163   -9.2878    0.0000 C   0  0
    3.6479   -8.9775    0.0000 S   0  0
    2.6459  -10.0938    0.0000 O   0  0
    4.1134  -10.4035    0.0000 O   0  0
    3.1815   -7.5510    0.0000 N   0  0
    1.7131   -7.2408    0.0000 C   0  0
    0.7130   -8.3588    0.0000 C   0  0
   -0.7552   -8.0517    0.0000 C   0  0
   -1.2234   -6.6267    0.0000 C   0  0
   -2.6917   -6.3197    0.0000 F   0  0
   -0.2234   -5.5086    0.0000 C   0  0
    1.2449   -5.8157    0.0000 C   0  0
    2.2449   -4.6977    0.0000 F   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 O   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  2  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14  8  1  0
 14 15  1  0
 13 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 24 26  1  0
 26 27  2  0
 27 18  1  0
 27 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28499

> <plate>
Kinase v5-2

> <well>
C12

> <supplier_cmpd_name>
PLX-4720

> <ctcr_id>
2026

> <supplier_cmpd_id>
S1152

> <smiles>
CCC[S](=O)(=O)Nc1ccc(F)c(c1F)C(=O)c2c[nH]c3ncc(Cl)cc23

> <pd_targets>
{FRK,ABL1,HIPK3,SLK,TNIK,FGFR1,SRMS,STK16,MINK1,DDR1,FLT1,KDR,LIMK1,AURKC,FES,BRAF,FYN,RAF1,KIT,EIF2AK4,NEK2,DDR2,MYLK4,ACVR2B,CAMK1,LCK,LIMK2,ABL2,PLK4,LYN,TGFBR2,CLK2,PTK6,AURKA,PTK2,OXSR1,MAP2K5,CS
F1R,PI4KB,CDK19,STK36,FGFR2,BMPR1B,PDGFRB,MAP2K4,FLT3,EPHB6,DCLK1,RIPK1,SIK1,HIPK4,MAP2K1,TNK2,CSNK1G2,PDGFRA,CLK1,FGR,SRC,YES1,SIK2,DYRK2,CSK,CDPK1,MAP3K20,HIPK1,RIOK2,HIPK2,SGK3,CDK8,AURKB,MAP2K2,TE
SK1,DCLK3,BLK,RIPK2,NEK11,PIR,PAK1,MAP4K5,MAP4K4,HCK}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,Transferase,Oxidoreductase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","STE protein kinase group","Other protein kinase group","TKL pro
tein kinase group","CAMK protein kinase group","CK1 protein kinase group","Atypical protein kinase group","AGC protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase Abl f
amily","CMGC protein kinase DYRK family","STE protein kinase STE20 family","Tyrosine protein kinase FGFR family","Other protein kinase NAK family","Tyrosine protein kinase DDR family","Tyrosine protei
n kinase VEGFR family","TKL protein kinase LISK family","Other protein kinase AUR family","Tyrosine protein kinase Fer family","TKL protein kinase RAF family","Tyrosine protein kinase PDGFR family","O
ther protein kinase PEK family","Other protein kinase NEK family","CAMK protein kinase MLCK family","TKL protein kinase STKR family","CAMK protein kinase CAMK1 family","Other protein kinase PLK family
","CMGC protein kinase CLK family","Tyrosine protein kinase Fak family","STE protein kinase STE7 family","CMGC protein kinase CDK family","Other protein kinase ULK family","CAMK protein kinase DCAMK1 
family","TKL protein kinase RIPK family","Tyrosine protein kinase Ack family","CK1 protein kinase CK1 family","Tyrosine protein kinase Csk family","TKL protein kinase MLK family","Atypical protein kin
ase RIO family","AGC protein kinase SGK family","CMGC protein kinase HIPK subfamily","STE protein kinase SLK subfamily","STE protein kinase MSN subfamily","Tyrosine protein kinase Srm","TKL protein ki
nase LIMK subfamily","Tyrosine protein kinase SrcA","Other protein kinase GCN2 subfamily","TKL protein kinase STKR Type 2 subfamily","STE protein kinase FRAY subfamily","CMGC protein kinase CDK8 subfa
mily","TKL protein kinase STKR Type 1 subfamily","CAMK protein kinase QIK subfamily","CMGC protein kinase Dyrk2 subfamily","TKL protein kinase MLK subfamily","Atypical protein kinase RIO2 subfamily","
TKL protein kinase TESK subfamily","Other protein kinase Nek11","STE protein kinase PAKA subfamily","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",
"CAMK: Calcium/calmodulin-dependent protein kinases","Lipid modifying kinases","CK1: Casein kinase 1",Atypical,"AGC: Containing PKA",PKG,"PKC families","TK: Tyrosine kinase","Dual-specificity tyrosine
-(Y)-phosphorylation regulated kinase (DYRK) family","STE20 family","Other protein kinases","TKL: Tyrosine kinase-like","Myosin Light Chain Kinase (MLCK) family","CAMK1 family","CLK family","STE7 fami
ly","1-phosphatidylinositol 4-kinase family","Cyclin-dependent kinase (CDK) family","DCAMKL family","CAMK-like (CAMKL) family","Casein kinase 1 (CK1) family","RIO family","SGK family","Non-receptor ty
rosine kinases (nRTKs)","HIPK subfamily","SLK subfamily","MSN subfamily","Receptor tyrosine kinases (RTKs)","NAK family","LIM domain kinase (LISK) family","Aurora kinase (Aur) family","RAF family","PE
K family","NIMA (never in mitosis gene a)- related kinase (NEK) family","Receptor serine/threonine kinase (RSTK) family","Polo-like kinase (PLK) family","FRAY subfamily","CDK8 subfamily","Unc-51-like 
kinase (ULK) family","Receptor interacting protein kinase (RIPK) family","QIK subfamily","Dyrk2 subfamily","Mixed Lineage Kinase (MLK) family","RIO2 subfamily","PAKA subfamily","KHS subfamily","Src fa
mily","Abl family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor famil
y","LIMK subfamily","Fer family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","GCN2 subfamily","Type II receptor serine/threonine kinases","Fak family","Type I receptor serine/threonine kina
ses","Type XIII RTKs: Ephrin receptor family","Ack family","Csk family","MLK subfamily","TESK subfamily"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Cellular responses to external stimuli","Extracellular matrix organization","Developmental Biology","Cell Cycle","Neuronal System","Gene expression (Transcription)",Met
abolism,"Immune System","Circadian Clock","Metabolism of RNA","Transport of small molecules","Cell-Cell communication","Digestion and absorption","Intracellular signaling by second messengers","Infect
ious disease","Cellular responses to stress","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Non-Receptor Tyrosine Kinases","Non-integrin membrane-ECM 
interactions","Signaling by Receptor Tyrosine Kinases","Nervous system development","MAPK family signaling cascades",Mitotic,"Signaling by NODAL","Transmission across Chemical Synapses","RNA Polymeras
e II Transcription","Metabolism of lipids","Signaling by TGFB family members","Innate Immune System","rRNA processing","Ion channel transport","Cell junction organization",Digestion,"PIP3 activates AK
T signaling","Leishmania infection","Cellular Senescence","Signaling by FGFR in disease","Signaling by PTK6","Signaling by VEGF","Axon guidance","Signaling by NTRKs","HIV Infection","MAPK1/MAPK3 signa
ling","Signaling by KIT in disease","Response of EIF2AK4 (GCN2) to amino acid deficiency","Regulation of mitotic cell cycle","Regulation of signaling by NODAL","Neurotransmitter receptors and postsyna
ptic signal transmission","Mitotic G2-G2/M phases","Signaling by TGF-beta Receptor Complex in Cancer","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Phospholipid metabolism","
Regulation of lipid metabolism by PPARalpha","Signaling by BMP","Toll-like Receptor Cascades","Signaling by Insulin receptor","Sphingolipid metabolism","Signaling by PDGFR in disease","Oncogenic MAPK 
signaling","rRNA processing in the nucleus and cytosol","Stimuli-sensing channels","Signaling by NOTCH1 in Cancer","M Phase","Cell-extracellular matrix interactions","PTEN Regulation","Parasite infect
ion","Oxidative Stress Induced Senescence","Signaling by FGFR1 in disease","PTK6 Down-Regulation","VEGF ligand-receptor interactions","VEGFA-VEGFR2 Pathway","Semaphorin interactions","Signaling by NTR
K1 (TRKA)","Host Interactions of HIV factors","RAF/MAP kinase cascade","Drug resistance of KIT mutants","APC/C-mediated degradation of cell cycle proteins","Activation of NMDA receptors and postsynapt
ic events","Signaling by ROBO receptors","G2/M Transition","Leishmania parasite growth and survival","Loss of Function of SMAD2/3 in Cancer","G1 Phase","Transcriptional Regulation by TP53","Transcript
ional Regulation by VENTX","PI Metabolism","PPARA activates gene expression","Signaling by FGFR2 in disease","Negative regulation of the PI3K/AKT network","Toll Like Receptor 5 (TLR5) Cascade","Insuli
n receptor signalling cascade","EPH-Ephrin signaling","Toll Like Receptor 4 (TLR4) Cascade","Sphingolipid de novo biosynthesis","Drug resistance of PDGFR mutants","Signaling by RAS mutants","Major pat
hway of rRNA processing in the nucleolus and cytosol","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Mitotic Metaphase and Anaphase","Regulation of cytoskeletal remodeling and cell spreading 
by IPP complex components","Transcriptional regulation by RUNX1","Regulation of PTEN stability and activity","Leishmania phagocytosis","FGFR1 mutant receptor activation","VEGF binds to VEGFR leading t
o receptor dimerization","VEGFR2 mediated cell proliferation","Sema4D in semaphorin signaling","CRMPs in Sema3A signaling","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathog
enesis","Negative regulation of MAPK pathway","Dasatinib-resistant KIT mutants","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Post NMDA receptor activation events","R
ole of ABL in ROBO-SLIT signaling","Centrosome maturation","Anti-inflammatory response favouring Leishmania parasite infection","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Cyclin D associated e
vents in G1","Regulation of TP53 Activity","Signalling to ERK5","Synthesis of PIPs at the Golgi membrane","FGFR2 mutant receptor activation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","MyD88 cas
cade initiated on plasma membrane","IRS-mediated signalling","EPHB-mediated forward signaling","MyD88-independent TLR4 cascade","Imatinib-resistant PDGFR mutants","Signaling downstream of RAS mutants"
,"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Mitotic Anaphase","RUNX1 regulates transcription of genes involved in BCR signaling","FCGR3A-mediated phagocytosis","Signaling by activated 
point mutants of FGFR1","Sema4D induced cell migration and growth-cone collapse","Prolonged ERK activation events","Nef and signal transduction","Negative feedback regulation of MAPK pathway","APC/C:C
dc20 mediated degradation of mitotic proteins","Activation of RAC1 downstream of NMDARs","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Loss of prote
ins required for interphase microtubule organization from the centrosome","FCGR3A-mediated IL10 synthesis","Regulation of TP53 Activity through Phosphorylation","Activated point mutants of FGFR2","MAP
 kinase activation","PI3K Cascade","TRIF(TICAM1)-mediated TLR4 signaling","Signalling to RAS","Separation of Sister Chromatids","ARMS-mediated activation","APC:Cdc20 mediated degradation of cell cycle
 proteins prior to satisfation of the cell cycle checkpoint","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes","JNK (c-Jun kinases) phosphorylation and  activation mediated by 
activated human TAK1","IKK complex recruitment mediated by RIP1","Frs2-mediated activation","p38MAPK events","activated TAK1 mediates p38 MAPK activation","APC-Cdc20 mediated degradation of Nek2A"}

> <broad_targets>
{BRAF,KDR}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{PLX-4720,PLX4720,918505-84-7,918505847,"PLX 4720",UNII-EQY31RO8HA,UNIIEQY31RO8HA,EQY31RO8HA,CHEBI:90295,C17H14ClF2N3O3S,"a,a-dimethoxytoluene","a,adimethoxytoluene",PubChem19346,3c4c,MLS006010065,SCH
EMBL133733,GTPL5703,CHEMBL1230020,BDBM25617,AMY2871,DTXSID10238711,EX-A186,EXA186,SYN1069,HMS3244C03,H,T2473,S1152}

> <pdid>
PD003519

> <targets>
{B-Raf,"B-RafV600E kinase Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{24180719}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5551   -4.4192    0.0000 N   0  0
    4.0559   -4.4171    0.0000 C   0  0
    4.8105   -5.7135    0.0000 C   0  0
    6.3105   -5.7082    0.0000 C   0  0
    7.0560   -4.4066    0.0000 C   0  0
    6.3014   -3.1102    0.0000 C   0  0
    4.8015   -3.1154    0.0000 C   0  0
    8.5568   -4.4014    0.0000 C   0  0
    9.3121   -5.6973    0.0000 F   0  0
    9.3018   -3.0995    0.0000 F   0  0
   10.0568   -4.3954    0.0000 F   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 O   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 N   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -5.1992    2.9855    0.0000 C   0  0
   -6.5537    3.5997    0.0000 N   0  0
   -7.5517    2.4800    0.0000 C   0  0
   -6.7952    1.1847    0.0000 C   0  0
   -5.3296    1.5040    0.0000 N   0  0
   -9.0426    2.6290    0.0000 C   0  0
   -9.6604    3.9959    0.0000 F   0  0
   -9.9177    1.4108    0.0000 F   0  0
  -10.5352    2.7776    0.0000 F   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  8 11  1  0
 11 12  1  0
 11 13  1  0
 11 14  1  0
  3 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 24 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 26  2  0
 28 31  1  0
 31 32  1  0
 31 33  1  0
 31 34  1  0
 18 35  2  0
 35 36  1  0
 36 37  2  0
 37  2  1  0
 37 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28500

> <plate>
Kinase v5-2

> <well>
C14

> <supplier_cmpd_name>
RAF265

> <ctcr_id>
5714

> <supplier_cmpd_id>
S2161

> <smiles>
Cn1c(Nc2ccc(cc2)C(F)(F)F)nc3cc(Oc4ccnc(c4)c5[nH]c(cn5)C(F)(F)F)ccc13

> <pd_targets>
{STK25,TYK2,SLK,KDR,DDR1,EPHA2,EPHA4,EPHA8,TIE1,HCK,NEK5,TNIK,KIT,MET,EPHA6,EIF2AK4,DDR2,PDGFRB,BLK,BRAF,MAP3K11,MAP3K7,ABL1,ABL2,TNK1,FLT1,FRK,CIT,FGFR1,LCK,LYN,TNNI3K,MAP3K20,RIPK1,MAP2K5,FLT3,MAP4K
4,MAP4K5,CDK19,CSF1R,FLT4,TEK,HIPK4,FER,YES1,EIF2AK2,RET,EPHA1,EPHB6,PTK6,PRKAA1,STK10,RAF1,TAOK2,SYK,PDGFRA,TAOK1,FYN,SRC,MAP4K2,RIPK2,MAP4K3,EPHA7,STK36,PAK3,MAP3K19,TAOK3}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","STE protein kinase group","TK protein kinase group","Other protein kinase group","TKL protein kinase group","AGC protein kinase group","CMGC pro
tein kinase group","CAMK protein kinase group","STE protein kinase STE20 family","Tyrosine protein kinase JakA family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase DDR family","Tyro
sine protein kinase Eph family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Src family","Other protein kinase NEK family","Tyrosine protein kinase PDGFR family","Tyrosine protein kin
ase Met family","Other protein kinase PEK family","TKL protein kinase RAF family","TKL protein kinase MLK family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Ack family","AGC protein
 kinase DMPK family","Tyrosine protein kinase FGFR family","TKL protein kinase RIPK family","STE protein kinase STE7 family","CMGC protein kinase CDK family","CMGC protein kinase DYRK family","Tyrosin
e protein kinase Fer family","Tyrosine protein kinase Ret family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Syk family","Other protein kinase ULK family","STE protein kinase STE11 fa
mily","STE protein kinase YSK subfamily","STE protein kinase SLK subfamily","STE protein kinase MSN subfamily","Other protein kinase GCN2 subfamily","TKL protein kinase MLK subfamily","TKL protein kin
ase TAK1 subfamily","AGC protein kinase CRIK subfamily","TKL protein kinase HH498 subfamily","STE protein kinase KHS subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase HIPK subfamily
","Other protein kinase PKR","CAMK protein kinase AMPK subfamily","STE protein kinase TAO subfamily","Tyrosine protein kinase SrcA","STE protein kinase PAKA subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","CMGC: 
Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","STE20 family","TK: Tyrosine kinase","Other protein kinases","TKL: Tyrosine kinase-like","DMPK family","ST
E7 family","Cyclin-dependent kinase (CDK) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CAMK-like (CAMKL) family","YSK subfamily","Non-receptor tyrosine kinas
es (nRTKs)","SLK subfamily","Receptor tyrosine kinases (RTKs)","NIMA (never in mitosis gene a)- related kinase (NEK) family","MSN subfamily","PEK family","RAF family","Mixed Lineage Kinase (MLK) famil
y","Other DMPK family kinases","Receptor interacting protein kinase (RIPK) family","KHS subfamily","CDK8 subfamily","HIPK subfamily","AMPK subfamily","TAO subfamily","Unc-51-like kinase (ULK) family",
"PAKA subfamily","STE20 subfamily","Janus kinase (JakA) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Type XIII RTK
s: Ephrin receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Src family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type X RTKs: HGF (hepatocyte growth factor) recept
or family","GCN2 subfamily","MLK subfamily","TAK1 subfamily","Abl family","Ack family","Type V RTKs: FGF (fibroblast growth factor) receptor family","HH498 subfamily","Fer family","Other PEK family ki
nases","Type XIV RTKs: RET","Syk family"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Extracellular matrix organization","Developmental Biology",Disease,"Cellular responses to external stimuli","Gene expression (Transcription)",Metabolism,"Cell C
ycle","Cytokine Signaling in Immune system","Signaling by Receptor Tyrosine Kinases","Non-integrin membrane-ECM interactions","Nervous system development","Infectious disease","Cellular responses to s
tress","Diseases of signal transduction by growth factor receptors and second messengers","Intracellular signaling by second messengers","RNA Polymerase II Transcription","Innate Immune System","Signa
ling by Rho GTPases","Metabolism of lipids","MAPK family signaling cascades",Mitotic,"Interferon Signaling","Signaling by VEGF","Axon guidance","HIV Infection","Cellular Senescence","Signaling by KIT 
in disease","Response of EIF2AK4 (GCN2) to amino acid deficiency","PIP3 activates AKT signaling","Generic Transcription Pathway","Signaling by NTRKs","Oncogenic MAPK signaling","Toll-like Receptor Cas
cades","Leishmania infection","RHO GTPase Effectors","Signaling by FGFR in disease","Signaling by Insulin receptor","Regulation of lipid metabolism by PPARalpha","MAPK1/MAPK3 signaling","Signaling by 
SCF-KIT","Influenza Infection","Mitotic G1 phase and G1/S transition","Neutrophil degranulation","Signaling by PDGFR in disease","M Phase","Interferon alpha/beta signaling","VEGFA-VEGFR2 Pathway","EPH
-Ephrin signaling","Host Interactions of HIV factors","Oxidative Stress Induced Senescence","Drug resistance of KIT mutants","Semaphorin interactions","Negative regulation of the PI3K/AKT network","Tr
anscriptional regulation by RUNX1","Signaling by NTRK1 (TRKA)","Signaling by RAS mutants","Toll Like Receptor 4 (TLR4) Cascade","Parasite infection","Signaling by ROBO receptors","VEGF ligand-receptor
 interactions","PTEN Regulation","RHO GTPases activate CIT","Signaling by FGFR1 in disease","Leishmania parasite growth and survival","Insulin receptor signalling cascade","PPARA activates gene expres
sion","Transcriptional Regulation by VENTX","RAF/MAP kinase cascade","NS1 Mediated Effects on Host Pathways","RET signaling","G1 Phase","Transcriptional Regulation by TP53","Drug resistance of PDGFR m
utants","Mitotic Metaphase and Anaphase","Toll Like Receptor 5 (TLR5) Cascade","Regulation of IFNA signaling","VEGFR2 mediated cell proliferation","EPHA-mediated growth cone collapse","The role of Nef
 in HIV-1 replication and disease pathogenesis","Dasatinib-resistant KIT mutants","Sema4D in semaphorin signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","RUNX1 regulates transcription of ge
nes involved in BCR signaling","Signalling to ERKs","Signaling downstream of RAS mutants","MyD88-independent TLR4 cascade","Leishmania phagocytosis","Role of ABL in ROBO-SLIT signaling","VEGF binds to
 VEGFR leading to receptor dimerization","Regulation of PTEN stability and activity","FGFR1 mutant receptor activation","Anti-inflammatory response favouring Leishmania parasite infection","Signalling
 to ERK5","IRS-mediated signalling","Inhibition of PKR","EPHB-mediated forward signaling","Cyclin D associated events in G1","Regulation of TP53 Activity","Negative regulation of MAPK pathway","Imatin
ib-resistant PDGFR mutants","Mitotic Anaphase","MyD88 cascade initiated on plasma membrane","Ephrin signaling","Nef and signal transduction","Sema4D mediated inhibition of cell attachment and migratio
n","Prolonged ERK activation events","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3A-mediated phagocytosis","Signaling by activated point mutants of FGFR1","Nef-mediates down modulation of cell surface
 receptors by recruiting them to clathrin adapters","FCGR3A-mediated IL10 synthesis","PI3K Cascade","Regulation of TP53 Activity through Phosphorylation","Negative feedback regulation of MAPK pathway"
,"Separation of Sister Chromatids","Signalling to RAS","MAP kinase activation","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Nef Mediated CD4 Down-regulati
on","IKK complex recruitment mediated by RIP1","p38MAPK events","activated TAK1 mediates p38 MAPK activation"}

> <broad_targets>
{BRAF}

> <broad_moa>
{"RAF inhibitor","VEGFR inhibitor"}

> <synonyms>
{RAF265,927880-90-8,927880908,CHIR-265,CHIR265,"RAF 265",RAF-265,RAF265(CHIR-265),RAF265(CHIR265),"CHIR 265","RAF265 (CHIR-265)","RAF265 (CHIR265)",UNII-8O434L3768,UNII8O434L3768,"RAF-265 (CHIR-265)",
8O434L3768,PubChem22594,NVP-RAF265,NVPRAF265,cc-117,cc117,SCHEMBL686452,CHEMBL558752,GTPL5674,BDBM31088,C24H16F6N6O,CHEBI:9145,S2161}

> <pdid>
PD003613

> <targets>
{VEGFR-PDGFR,Raf,VEGFR,Apoptosis,Autophagy}

> <classes>
{MAPK,Apoptosis,Autophagy,MAPK/ERK Pathway,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{11656518}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 20  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.1471   -2.9705    0.0000 N   0  0
   -4.6471   -2.9705    0.0000 N   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  7  1  0
 15 10  1  0
 14 16  1  0
 16  4  1  0
 16 17  2  0
M  END
> <name>
UTKinase_V5

> <id>
28501

> <plate>
Kinase v5-2

> <well>
C16

> <supplier_cmpd_name>
SP600125

> <ctcr_id>
11925

> <supplier_cmpd_id>
S1460

> <smiles>
c1ccc2c(c1)c1n[nH]c3cccc(c13)c2=O

> <pd_targets>
{MAPK10,MAPK9,MAPK8,EIF2AK2,TTK,JAK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","TK protein kinase group","CMGC protein kinase MAPK family","Other protein kinase PEK family","Other protein ki
nase TTK family","Tyrosine protein kinase JakA family","CMGC protein kinase JNK subfamily","Other protein kinase PKR"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Mitogen-activated protein kinases (MAP kinases)","Other protein kina
ses","TK: Tyrosine kinase","JNK subfamily","PEK family","TTK family","Non-receptor tyrosine kinases (nRTKs)","Other PEK family kinases","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Immune System",Disease,"Innate Immune System","Infectious disease","Cytokine Signaling in Immune system","Toll-like Receptor Cascades","Influenza Infection","Signaling by Interleukins","Toll Like Re
ceptor 5 (TLR5) Cascade","NS1 Mediated Effects on Host Pathways","Interleukin-2 family signaling","MyD88 cascade initiated on plasma membrane","Inhibition of PKR","Interleukin-15 signaling","MAP kinas
e activation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{129-56-6,129566,"1,9-Pyrazoloanthrone","1,9Pyrazoloanthrone",SP600125,Pyrazolanthrone,"Dibenzo(cd,g)indazol-6(2H)-one","Dibenzo(cd,g)indazol6(2H)one",Pyrazoleanthrone,"SP 600125","Anthra(1,9-cd)pyraz
ol-6(2H)-one","Anthra(1,9cd)pyrazol6(2H)one",SP-600125,"Anthra-1,9-pyrazol-6-none","Anthra1,9pyrazol6none","JNK Inhibitor II",2H-Dibenzo(cd,2HDibenzo(cd,g)indazol-6-on,g)indazol6on,T3109}

> <pdid>
PD002737

> <targets>
{JNK,"Aurora A",JNK1,JNK2,JNK3,TrkA}

> <classes>
{"Cell Cycle/Checkpoint",MAPK,"Tyrosine Kinase/Adaptors",Chromatin/Epigenetic}

> <pubchem_cids>
{8515}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    2.6030   -2.9977    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    6.4995   -3.7432    0.0000 C   0  0
    7.7985   -2.9932    0.0000 C   0  0
    7.7985   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    6.5025    0.7576    0.0000 C   0  0
    5.2048    1.5099    0.0000 O   0  0
    7.8026    1.5057    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 N   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 C   0  0
   -1.2942   -8.2509    0.0000 O   0  0
    0.0036   -7.4988    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
  2 13  1  0
 13 14  2  3
 14 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  2  3
 21 22  1  0
 22 23  2  3
 23 13  1  0
 23 17  1  0
 21 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 15 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28502

> <plate>
Kinase v5-2

> <well>
C18

> <supplier_cmpd_name>
AZD6482

> <ctcr_id>
1683

> <supplier_cmpd_id>
S1462

> <smiles>
CC(Nc1ccccc1C(O)=O)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C

> <pd_targets>
{PIK3CB,PIK3CG,PIK3CD,PIK3CA,PIK3R1,PIK3R2,PIK3R3,PIK3R5}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,"Immune System",Disease,"Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","Cytokine Signaling in Immune system","Diseases of signal transduction by grow
th factor receptors and second messengers","Signaling by Insulin receptor","Phospholipid metabolism","Signaling by Interleukins","Signaling by FGFR in disease","Insulin receptor signalling cascade","P
I Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Signaling by FGFR1 in disease","IRS-mediated signalling","Synthesis of PIPs at the plasma membrane","Interleukin receptor SHC signalin
g","FGFR1 mutant receptor activation","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
{PIK3CA,PIK3CB,PIK3CD,PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{663620-70-0,663620700,"(Rac)-AZD 6482","(Rac)AZD 6482",(Rac)-KIN-193,(Rac)KIN193,AZD-6482,AZD6482,SCHEMBL825695,CHEMBL2133638,HMS3265K07,HMS3265K08,HMS3265L07,HMS3265L08,HMS3654B12,HMS3750G11,BCP0226
3,CS-M0111,CSM0111,AKOS032947289,4-dodecylbenzyltrimethylammoniumchloride,4dodecylbenzyltrimethylammoniumchloride,NCGC00389715-01,NCGC0038971501,CS-14179,CS14179,DA-,DA,T6087,S1462}

> <pdid>
PD003410

> <targets>
{PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{10364098}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 20  0  0  0  0            999 V2000
    0.9513   -6.4982    0.0000 O   0  0
    1.8372   -5.2877    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    3.8056   -3.8679    0.0000 C   0  0
    5.2311   -3.4009    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.3786   -3.8595    0.0000 S   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  2  1  0
  6  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 12  1  0
 17 18  2  0
 18  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28503

> <plate>
Kinase v5-2

> <well>
C20

> <supplier_cmpd_name>
AS-605240

> <ctcr_id>
7724

> <supplier_cmpd_id>
S1410

> <smiles>
O=C1NC(=O)/C(S1)=C/c2ccc3nccnc3c2

> <pd_targets>
{MAOB,NPC1,PIK3CG,PIK3CD,PIK3CB,CLK1,PIK3CA,CSNK2A1,CSNK2A2,CSNK2B,CISD1,RAB9A,MTOR,DYRK1A,DYRK2,DYRK1B}

> <pathway_gtopdb>
{Enzyme,Transporter,"Unclassified protein",Oxidoreductase,Transferase,Kinase,Hydrolase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","Atypical protein kinase group","CMGC p
rotein kinase CLK family","Other protein kinase CK2 family","Atypical protein kinase PIKK family","CMGC protein kinase DYRK family","Atypical protein kinase FRAP subfamily","CMGC protein kinase Dyrk1 
subfamily","CMGC protein kinase Dyrk2 subfamily"}

> <pathway_chembl>
{Enzymes,Transporters,"Catecholamine turnover","SLC superfamily of solute carriers","Kinases (EC 2.7.x.x)","SLC65 NPC-type cholesterol transporters","Lipid modifying kinases","CMGC: Containing CDK",MA
PK,GSK3,"CLK families",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","CLK family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Dual-specificity tyrosine-(Y)-phos
phorylation regulated kinase (DYRK) family","FRAP subfamily","Dyrk1 subfamily","Dyrk2 subfamily"}

> <pathway_reactome>
{Metabolism,"Transport of small molecules","Immune System","Signal Transduction",Disease,"Gene expression (Transcription)","Cell Cycle","Biological oxidations","Plasma lipoprotein assembly",remodeling
,"and clearance","Metabolism of lipids","Cytokine Signaling in Immune system","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers
","Signaling by Rho GTPases","RNA Polymerase II Transcription",Mitotic,"Phase I - Functionalization of compounds","Plasma lipoprotein clearance","Phospholipid metabolism","Signaling by Interleukins","
Signaling by Insulin receptor","Signaling by FGFR in disease","Rho GTPase cycle","Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","Amine Oxidase reactions","LDL clearance","PI Me
tabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","Signaling by FGFR1 in disease","RHOBTB GTPase Cycle","Transcriptional Regulation by TP53","G0 and Ea
rly G1","Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB","Synthesis of PIPs at the plasma membrane","Interleukin receptor SHC signaling","IRS-mediated signalling","FGFR1 muta
nt receptor activation","RHOBTB3 ATPase cycle","Regulation of TP53 Activity","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation","Regulation of
 TP53 Activity through Phosphorylation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{S008,"S 008",CS-0084,CS0084,"CS 0084",DB04769,AS-605240,AS605240,"AS 605240",648450-29-7,648450297,"648450 29 7","5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE","5QUINOXALIN6YLMETHYLENETHIAZOLIDI
NE2,4DIONE","5 QUINOXALIN 6 YLMETHYLENE THIAZOLI","EMD 528106",S1410,528106}

> <pdid>
PD006408

> <targets>
{PI3K}

> <classes>
{}

> <pubchem_cids>
{5289247}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 40  0  0  0  0            999 V2000
    7.3352    6.5059    0.0000 C   0  0
    8.0901    5.2097    0.0000 S   0  0
    9.5901    5.2159    0.0000 O   0  0
    8.8349    6.5117    0.0000 O   0  0
    7.3442    3.9074    0.0000 N   0  0
    8.0987    2.6109    0.0000 C   0  0
    7.3533    1.3093    0.0000 C   0  0
    5.8532    1.3040    0.0000 N   0  0
    5.1047    0.0031    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.7248    1.2135    0.0000 S   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -4.2128    0.7135    0.0000 C   0  0
   -5.7049    0.8679    0.0000 N   0  0
   -6.3128   -0.5034    0.0000 N   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
    5.0987    2.6005    0.0000 C   0  0
    5.8442    3.9021    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  2  0
  2  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 10  1  0
 13 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  2  3
 18 12  1  0
 17 19  1  0
 19 20  2  3
 20 21  1  0
 21 22  2  3
 22 23  1  0
 23 24  1  0
 24 20  1  0
 24 25  2  3
 25 26  1  0
 26 27  2  3
 27 19  1  0
 15 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 28  1  0
  8 34  1  0
 34 35  1  0
 35  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28504

> <plate>
Kinase v5-2

> <well>
C22

> <supplier_cmpd_name>
GDC-0941

> <ctcr_id>
11433

> <supplier_cmpd_id>
S1065

> <smiles>
CS(=O)(=O)N1CCN(CC2=CC3=C(S2)C(=NC(=N3)C2=C3C=NNC3=CC=C2)N2CCOCC2)CC1

> <pd_targets>
{NTRK1,PIK3CG,MTOR,CLK4,HIPK1,PIK3CB,PIK3CA,PIK3C2G,DAPK1,GAK,DAPK3,CAMK1G,HIPK2,PIK3R1,IRAK3,PIK3C2B,PI4KB,MAPK8,HIPK3,FLT3,PIK3CD,CLK1,STK16,CSNK1D,PRKDC,MYLK4,MAP3K19,CAMK1,CDK7,JAK1,TYK2,RPS6KA3,C
ILK1,PLK4,AAK1,CLK2,MAPK9,CSNK1E,CDK18,EPHB6,MELK,TTK,RIOK2,PIK3C3,PIK3R2,RPS6KA6,MAPK10,PIK3C2A,PIK3R5,CDK16,CSNK2A2,DYRK2,KCNH2,ABCB11,ABCC4,HIPK4,LRRK2,DYRK1B,AKT1,PIK3R3}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Ion channel",Transporter,Kinase,Transferase,"Voltage-gated ion channel","Primary active transporter","Protein Kinase","Potassium channels","ATP-binding cassette","TK pr
otein kinase group","Atypical protein kinase group","CMGC protein kinase group","CAMK protein kinase group","Other protein kinase group","TKL protein kinase group","CK1 protein kinase group","STE prot
ein kinase group","AGC protein kinase group","Voltage-gated potassium channel","ABCB subfamily","ABCC subfamily","Tyrosine protein kinase Trk family","Atypical protein kinase PIKK family","CMGC protei
n kinase CLK family","CMGC protein kinase DYRK family","CAMK protein kinase DAPK family","Other protein kinase NAK family","CAMK protein kinase CAMK1 family","TKL protein kinase IRAK family","CMGC pro
tein kinase MAPK family","Tyrosine protein kinase PDGFR family","CK1 protein kinase CK1 family","CAMK protein kinase MLCK family","STE protein kinase STE11 family","CMGC protein kinase CDK family","Ty
rosine protein kinase JakA family","AGC protein kinase RSK family","CMGC protein kinase RCK family","Other protein kinase PLK family","Other protein kinase TTK family","Atypical protein kinase RIO fam
ily","Other protein kinase CK2 family","TKL protein kinase LRRK family","AGC protein kinase AKT family","Atypical protein kinase FRAP subfamily","CMGC protein kinase HIPK subfamily","CMGC protein kina
se JNK subfamily","CMGC protein kinase CDK7 subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase MAK","CMGC protein kinase PCTAIRE","CAMK protein kinase MELK subfamily","Atypical protein
 kinase RIO2 subfamily","CMGC protein kinase TAIRE subfamily","CMGC protein kinase Dyrk2 subfamily","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels",Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)","Glycerophospholipid turnover","Voltage-gated ion channels","ATP-binding cassette transporter family","Recep
tor kinases","Lipid modifying kinases",Atypical,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","Phosphatidylinositol kinases","CK1: Casein kinase 
1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","Potassium channels","ABCB subfamily","ABCC subfamily","TK: Tyrosine kinase",Phosphatid
ylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","CLK family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family
","Phosphatidylinositol-4-phosphate 3-kinase family","Death-associated kinase (DAPK) family","Other protein kinases","CAMK1 family","TKL: Tyrosine kinase-like","1-phosphatidylinositol 4-kinase family"
,"Mitogen-activated protein kinases (MAP kinases)","Casein kinase 1 (CK1) family","Myosin Light Chain Kinase (MLCK) family","STE20 family","Cyclin-dependent kinase (CDK) family","RSK family","RCK fami
ly","CAMK-like (CAMKL) family","RIO family","Phosphatidylinositol 3-kinase family","Voltage-gated potassium channels","Akt (Protein kinase B","PKB) family","Receptor tyrosine kinases (RTKs)","FRAP sub
family","HIPK subfamily","Numb-associated kinase (NAK) family","Interleukin-1 receptor-associated kinase (IRAK) family","JNK subfamily","NAK family","Other PIKK family kinases","STE20 subfamily","CDK7
 subfamily","Non-receptor tyrosine kinases (nRTKs)","RSK subfamily","Polo-like kinase (PLK) family","TAIRE subfamily","MELK subfamily","TTK family","RIO2 subfamily","Casein kinase 2 (CK2) family","Dyr
k2 subfamily","Leucine-rich repeat kinase (LRRK) family","Dyrk1 subfamily","Type VII RTKs: Neurotrophin receptor/Trk family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Janus kinase (JakA)
 family","Type XIII RTKs: Ephrin receptor family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,"Gene expression (Transcription)",Disease,"Programmed Cell Death","Vesicle-mediated transport","Immune System","Cell Cycle","Neuronal System","Developmental Biology",
"Metabolism of RNA","Muscle contraction",Hemostasis,"Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor 
receptors and second messengers",Apoptosis,"Membrane Trafficking","Innate Immune System","Cytokine Signaling in Immune system",Mitotic,"Transmission across Chemical Synapses","Infectious disease","Ner
vous system development","rRNA processing","Cardiac conduction","Platelet activation","signaling and aggregation","Signaling by Non-Receptor Tyrosine Kinases","Signaling by NTRKs","Phospholipid metabo
lism","Generic Transcription Pathway","Signaling by Insulin receptor","Signaling by FGFR in disease","Caspase activation via extrinsic apoptotic signalling pathway","trans-Golgi Network Vesicle Buddin
g","Toll-like Receptor Cascades","Signaling by Interleukins","Mitotic G2-G2/M phases","Cytosolic sensors of pathogen-associated DNA","Neurotransmitter receptors and postsynaptic signal transmission","
HIV Infection","Interferon Signaling","Clathrin-mediated endocytosis","Axon guidance","rRNA processing in the nucleus and cytosol","Phase 3 - rapid repolarisation","Metabolism of steroids","Response t
o elevated platelet cytosolic Ca2+","Signaling by PTK6","Signaling by NTRK1 (TRKA)","PI Metabolism","Transcriptional Regulation by TP53","Insulin receptor signalling cascade","Signaling by FGFR1 in di
sease","Caspase activation via Dependence Receptors in the absence of ligand","Golgi Associated Vesicle Biogenesis","Toll Like Receptor 2 (TLR2) Cascade","Toll Like Receptor 5 (TLR5) Cascade",Interleu
kin-3,"Interleukin-5 and GM-CSF signaling","G2/M Transition","STING mediated induction of host immune responses","Activation of NMDA receptors and postsynaptic events","HIV Life Cycle","Antiviral mech
anism by IFN-stimulated genes","Interferon alpha/beta signaling","Cargo recognition for clathrin-mediated endocytosis","EPH-Ephrin signaling","Major pathway of rRNA processing in the nucleolus and cyt
osol","Bile acid and bile salt metabolism","Platelet degranulation","PTK6 promotes HIF1A stabilization","Signalling to ERKs","Synthesis of PIPs at the plasma membrane","Regulation of TP53 Activity","I
RS-mediated signalling","FGFR1 mutant receptor activation","Synthesis of PIPs at the Golgi membrane","Toll Like Receptor TLR6:TLR2 Cascade","MyD88 cascade initiated on plasma membrane","Interleukin re
ceptor SHC signaling","Centrosome maturation","IRF3-mediated induction of type I IFN","Post NMDA receptor activation events","Late Phase of HIV Life Cycle","ISG15 antiviral mechanism","Regulation of I
FNA signaling","EPHB-mediated forward signaling","Synthesis of PIPs at the early endosome membrane","Synthesis of bile acids and bile salts","Prolonged ERK activation events","Regulation of TP53 Expre
ssion and Degradation","Regulation of TP53 Activity through Phosphorylation","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","MAP k
inase activation","Loss of proteins required for interphase microtubule organization from the centrosome","Activation of RAC1 downstream of NMDARs","Transcription of the HIV genome","CREB1 phosphoryla
tion through NMDA receptor-mediated activation of RAS signaling","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","ARMS-mediated activation","Regulation of TP53 Degradation","MAP
K targets/ Nuclear events mediated by MAP kinases","Loss of Nlp from mitotic centrosomes","HIV Transcription Elongation","RSK activation","Activation of the AP-1 family of transcription factors","Tat-
mediated elongation of the HIV-1 transcript","CREB phosphorylation","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{957054-30-7,957054307,GDC-0941,GDC0941,PICTILISIB,Pictrelisib,"GDC 0941",UNII-ICY00EMP8P,UNIIICY00EMP8P,"Pictilisib (GDC-0941)","Pictilisib (GDC0941)",ICY00EMP8P,"GDC-0941 (Pictilisib)","GDC0941 (Pic
tilisib)",CHEBI:65326,"957054-30-7 (free base)","957054307 (free base)",C23H27N7O3S2,GD9,957054-50-1,957054501,"Pictilisib (USAN:INN)","Pictilisib (US",T1994,Pictilisib}

> <pdid>
PD003253

> <targets>
{PI3K,p110¦Á,p110¦Â,p110¦Ã,p110¦Ä}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{17755052}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8978   -0.7496    0.0000 C   0  0
   -5.1981   -1.4975    0.0000 C   0  0
   -6.4959   -0.7455    0.0000 C   0  0
   -6.4936    0.7545    0.0000 C   0  0
   -5.1933    1.5025    0.0000 C   0  0
   -3.8955    0.7504    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
  4 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28505

> <plate>
Kinase v5-2

> <well>
E04

> <supplier_cmpd_name>
LY294002

> <ctcr_id>
4842

> <supplier_cmpd_id>
S1105

> <smiles>
O=C1C=C(Oc2c1cccc2c3ccccc3)N4CCOCC4

> <pd_targets>
{BLM,LMNA,GMNN,ALDH1A1,SMN1,PMP22,KDM4E,PIK3CD,PIK3CB,PRKDC,PIK3CA,MTOR,PIK3CG,PLK1,PIK3R1,PIK3R2,PIK3C2B,PIM3,CYP2D6,CYP1A2,PIM1,NFKB1,CYP2C19,CYP3A4,PLK3,PDE2A,TSHR,BRD3,PLK2,HIF1A,ALOX15,THPO,CYP2C
9,BRD4,BRD2,PIK3C2A,HSD17B10,CDK8,PDE3A,PDE3B,GSK3B,CSNK2A1,CSNK2A2,CSNK2B,HTR2B,PDE5A,HTR2A,CACNA1C,CACNB2,HTR2C}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein","Unclassified protein","Epigenetic regulator","Other cytosolic protein","Membrane receptor","Transcription factor","Ion channel",Oxidoreductase,Reader,Eraser,Transferas
e,Kinase,Protease,"Cytochrome P450",Phosphodiesterase,"Family A G protein-coupled receptor","Voltage-gated ion channel","Methyl-lysine/arginine binding protein","Lysine demethylase","Protein Kinase","
Cysteine protease","Cytochrome P450 family 2","Cytochrome P450 family 1","Cytochrome P450 family 3","Phosphodiesterase 2","Peptide receptor (family A GPCR)",Bromodomain,"Phosphodiesterase 3","Small mo
lecule receptor (family A GPCR)","Phosphodiesterase 5","Voltage-gated calcium channel","Tudor domain","Jumonji domain-containing","Atypical protein kinase group","Other protein kinase group","CAMK pro
tein kinase group","Cysteine protease CA clan","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Cytochrome P450 family 2C","Cytochrome P450 family 3A","Phosphodiesterase 2A","Glycohormone rece
ptor","CMGC protein kinase group","Phosphodiesterase 3A","Monoamine receptor","Phosphodiesterase 5A","Atypical protein kinase PIKK family","Other protein kinase PLK family","CAMK protein kinase PIM fa
mily","Cysteine protease C1A family","Cytochrome P450 2D6","Cytochrome P450 1A1","Cytochrome P450 2C19","Cytochrome P450 3A4","Cytochrome P450 2C9","CMGC protein kinase CDK family","CMGC protein kinas
e GSK family","Other protein kinase CK2 family","Serotonin receptor","Atypical protein kinase FRAP subfamily","Other protein kinase PLK2","CMGC protein kinase CDK8 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Chromatin modifying enzymes","Kinases (EC 2.7.x.x)","Catalytic receptors","Glycerophospholipid turnover","Cytochrome P450","Cyclic nucleotide turnover/signalling","G protein-couple
d receptors","Eicosanoid turnover","1.14.11.- Histone demethylases","Lipid modifying kinases",Atypical,"Receptor kinases","Phosphatidylinositol kinases","CAMK: Calcium/calmodulin-dependent protein kin
ases","CYP2 family: drug metabolising subset","CYP1 family","CYP3 family",Phosphodiesterases,3',"5'-cyclic nucleotide (PDEs)","Glycoprotein hormone receptors","Enzymatic bromodomain-containing protein
s",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","5-Hydroxytryptamine receptors",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinase
s (PIKK) family","Other protein kinases","Phosphatidylinositol-4-phosphate 3-kinase family","PIM family","Bromodomain kinase (BRDK) family","Cyclin-dependent kinase (CDK) family","Glycogen synthase ki
nase (GSK) family","Other PIKK family kinases","FRAP subfamily","Polo-like kinase (PLK) family","CDK8 subfamily","GSK subfamily"}

> <pathway_reactome>
{"DNA Repair","Cell Cycle",Metabolism,"Metabolism of RNA","Developmental Biology","Immune System","Signal Transduction",Disease,"Gene expression (Transcription)",Hemostasis,"Cellular responses to exte
rnal stimuli","DNA Double-Strand Break Repair",Mitotic,"Biological oxidations","Metabolism of non-coding RNA","Nervous system development","Cytokine Signaling in Immune system","Signaling by Receptor 
Tyrosine Kinases","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Metabolism of lipids","Platelet homeostas
is","Infectious disease","Cellular responses to stress","Platelet activation","signaling and aggregation","Metabolism of amino acids and derivatives","Signaling by GPCR","Homology Directed Repair","M 
Phase","Mitotic G1 phase and G1/S transition","Phase I - Functionalization of compounds","snRNP Assembly","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Signaling by Interleukins","
Signaling by Insulin receptor","Cytosolic sensors of pathogen-associated DNA","Signaling by FGFR in disease","Generic Transcription Pathway","Phospholipid metabolism","Mitotic G2-G2/M phases","FLT3 si
gnaling in disease","Biosynthesis of specialized proresolving mediators (SPMs)","Nitric oxide stimulates guanylate cyclase","Leishmania infection","Cellular response to hypoxia","Platelet Aggregation 
(Plug Formation)","SARS-CoV Infections","Branched-chain amino acid catabolism","Signaling by NOTCH1 in Cancer","GPCR ligand binding","HDR through Homologous Recombination (HRR) or Single Strand Anneal
ing (SSA)","Mitotic Metaphase and Anaphase","G1/S Transition","Ethanol oxidation",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","STING mediated induction of 
host immune responses","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","PI Metabolism","G2/M Transition","Cytochrome P450 - arranged by substrate type","Signaling by FLT3 ITD and 
TKD mutants","Interleukin-1 family signaling","Biosynthesis of DHA-derived SPMs","cGMP effects","Leishmania parasite growth and survival","Oxygen-dependent proline hydroxylation of Hypoxia-inducible F
actor Alpha","Biosynthesis of DPA-derived SPMs","Potential therapeutics for SARS","Transcriptional regulation by RUNX3","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","SARS-CoV-1 Infection","C
lass A/1 (Rhodopsin-like receptors)","HDR through Homologous Recombination (HRR)","Mitotic Anaphase","Activation of the pre-replicative complex","Interleukin receptor SHC signaling","IRS-mediated sign
alling","IRF3-mediated induction of type I IFN","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Synthesis of PIPs at the plasma membrane","Centrosome maturation",Xenobiotics,"STAT5 a
ctivation downstream of FLT3 ITD mutants","Interleukin-1 signaling","Biosynthesis of maresins","Anti-inflammatory response favouring Leishmania parasite infection","Biosynthesis of DPAn-3 SPMs","RUNX3
 regulates p14-ARF","Synthesis of PIPs at the early endosome membrane","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","SARS-CoV-1 Genome Replication and Transcription","Amine ligand-binding
 receptors","Homologous DNA Pairing and Strand Exchange","Nuclear Envelope (NE) Reassembly","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation"
,"Loss of proteins required for interphase microtubule organization from the centrosome","CYP2E1 reactions","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent 
MAPK1/3 activation","Biosynthesis of maresin-like SPMs","Regulation of TP53 Activity through Phosphorylation","ADORA2B mediated anti-inflammatory cytokines production","CD163 mediating an anti-inflamm
atory response","Biosynthesis of DPAn-3-derived protectins and resolvins","Replication of the SARS-CoV-1 genome","Serotonin receptors","Presynaptic phase of homologous DNA pairing and strand exchange"
,"Initiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{AKT1,CHEK1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,MTOR,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PLK1,PRKCA,PRKDC,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"DNA dependent protein kinase inhibitor","mTOR inhibitor","phosphodiesterase inhibitor","PI3K inhibitor","PLK inhibitor"}

> <synonyms>
{154447-36-6,154447366,LY294002,"LY 294002",LY-294002,2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one,2(4Morpholinyl)8phenyl4H1benzopyran4one,2-morpholino-8-phenyl-4H-chromen-4-one,2morpholino8phenyl
4Hchromen4one,2-morpholin-4-yl-8-phenyl-4H-chromen-4-one,2morpholin4yl8phenyl4Hchromen4one,UNII-31M2U1DVID,UNII31M2U1DVID,2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one,2(morpholin4yl)8phenyl4Hchromen4o
ne,31M2U1DV,T4079,T2008,"EMD 440202",S1105,ST-420,"LY-294002 hydrochloride",440202}

> <pdid>
PD007784

> <targets>
{PI3K,"PI 3-K",Apoptosis,Autophagy,"Casein Kinase",DNA-PK}

> <classes>
{Apoptosis,Autophagy,Cell Cycle/DNA Damage,PI3K/Akt/mTOR,Stem Cell/Wnt}

> <pubchem_cids>
{3973}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    3.9015    0.7475    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    2.5972    1.5031    0.0000 C   0  0
    2.5951    3.0039    0.0000 N   0  0
    1.3787    3.8597    0.0000 N   0  0
    1.8375    5.2879    0.0000 C   0  0
    3.3367    5.2926    0.0000 C   0  0
    4.3367    6.4106    0.0000 C   0  0
    3.8684    7.8357    0.0000 N   0  0
    5.8050    6.1036    0.0000 N   0  0
    6.2732    4.6786    0.0000 C   0  0
    5.2732    3.5606    0.0000 N   0  0
    3.8050    3.8675    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17 11  1  0
 17 18  1  0
 18  8  1  0
 18 19  2  0
  9 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 21  1  0
 30 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28506

> <plate>
Kinase v5-2

> <well>
E06

> <supplier_cmpd_name>
PIK-293

> <ctcr_id>
647

> <supplier_cmpd_id>
S2207

> <smiles>
Cc1ccccc1N2C(=Nc3cccc(C)c3C2=O)Cn4ncc5c(N)ncnc45

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{PIK3CA,PIK3CB,PIK3CD,PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{IK29,PIK-293,PIK293,900185-01-5,900185015,"PIK 293",cc-612,cc612,MLS006010992,SCHEMBL1296650,CHEMBL3182327,DTXSID40692887,EX-A880,EXA880,HMS3655H10,BCP02571,MFCD20272930,s2207,ZINC51768817,AKOS030627
137,CCG-268621,CCG268621,NCGC00346579-01,NCGC0034657901,NCGC00346579-02,NCGC0034657902,NCGC00346579-03,NCGC0034657903,AC-33120,AC33120,HY-1,HY1,T3348,S2207}

> <pdid>
PD010826

> <targets>
{PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{53245636}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.9095    2.9665    0.0000 N   0  0
   -4.4013    3.1233    0.0000 C   0  0
   -5.0114    1.7529    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 O   0  0
    1.3032   -3.7490    0.0000 C   0  0
   -5.1953   -1.5031    0.0000 N   0  0
   -5.1932   -3.0039    0.0000 C   0  0
   -3.8928   -3.7517    0.0000 O   0  0
   -6.4914   -3.7570    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -7.7904   -6.0071    0.0000 C   0  0
   -9.0895   -5.2571    0.0000 C   0  0
   -9.0895   -3.7571    0.0000 N   0  0
   -7.7905   -3.0071    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11  7  1  0
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14  6  1  0
 14 15  2  0
 15  3  1  0
 15 16  1  0
 16 17  1  0
 12 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28507

> <plate>
Kinase v5-2

> <well>
E08

> <supplier_cmpd_name>
PIK-90

> <ctcr_id>
1133

> <supplier_cmpd_id>
S1187

> <smiles>
COc1ccc2C3=NCCN3C(=Nc2c1OC)NC(=O)c4cccnc4

> <pd_targets>
{PIK3C2B,PIK3CA,PIK3CB,PIK3CG,PRKDC,PIK3C2A,PIK3R1,PIK3CD,PIK3C3}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,"Phosphatidylinositol-4-phosphate 3-kinase family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' 
kinase-related kinases (PIKK) family","Phosphatidylinositol 3-kinase family","Other PIKK family kinases"}

> <pathway_reactome>
{Metabolism,Disease,"Signal Transduction","Immune System","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kina
ses","Innate Immune System","Cytokine Signaling in Immune system","Phospholipid metabolism","Signaling by FGFR in disease","Signaling by Insulin receptor","Cytosolic sensors of pathogen-associated DNA
","Signaling by Interleukins","PI Metabolism","Signaling by FGFR1 in disease","Insulin receptor signalling cascade","STING mediated induction of host immune responses",Interleukin-3,"Interleukin-5 and
 GM-CSF signaling","Synthesis of PIPs at the plasma membrane","FGFR1 mutant receptor activation","IRS-mediated signalling","IRF3-mediated induction of type I IFN","Synthesis of PIPs at the early endos
ome membrane","Interleukin receptor SHC signaling","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{PIK90,"PIK 90",T2461,S1187,PIK-90}

> <pdid>
PD013020

> <targets>
{PI3K,"PI3K ALPHA"}

> <classes>
{}

> <pubchem_cids>
{6857685}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 25  0  0  0  0            999 V2000
    2.4283   -5.7163    0.0000 C   0  0
    3.9195   -5.8781    0.0000 C   0  0
    4.5246   -7.2506    0.0000 O   0  0
    4.8054   -4.6666    0.0000 N   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988   -1.5004    0.0000 S   0  0
   -2.5983   -3.0004    0.0000 O   0  0
   -3.8975   -2.2510    0.0000 O   0  0
   -3.8990   -0.7508    0.0000 N   0  0
   -5.1988   -1.5013    0.0000 C   0  0
   -6.4990   -0.7517    0.0000 C   0  0
   -7.7980   -1.5017    0.0000 O   0  0
    4.2566    0.5871    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9  5  1  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 10  1  0
 15 17  1  0
 17 18  2  0
 17 19  2  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
  7 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28508

> <plate>
Kinase v5-2

> <well>
E10

> <supplier_cmpd_name>
PIK-93

> <ctcr_id>
2529

> <supplier_cmpd_id>
S1489

> <smiles>
CC(=O)N=C1NC(=C(S1)c2ccc(Cl)c(c2)[S](=O)(=O)NCCO)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{IK9,PIK-93,PIK93,AKOS016362896,CCG-264899,CCG264899,CS-0203,CS0203,DB06836,SB19248,NCGC00346536-01,NCGC0034653601,NCGC00346536-06,NCGC0034653606,AC-32793,AC32793,AS-16222,AS16222,HY-12046,HY12046,SMR
004702780,FT-0761476,FT0761476,SW219245-1,SW2192451,X7414,W-5546,W5546,960P113,J-523090,J523090,Q27088391,593960-11-3,593960113,"PIK 93",CHEMBL1229535,N-(5-(4-CHLORO-3,N(5(4CHLORO3,S1489}

> <pdid>

> <targets>
{PI3K,VEGFR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{6852167}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -6.4995    3.7483    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -9.0928    0.7442    0.0000 O   0  0
   -6.4948    0.7483    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968   -1.5004    0.0000 C   0  0
   -6.4971   -0.7525    0.0000 C   0  0
   -7.7950   -1.5046    0.0000 C   0  0
   -7.7926   -3.0046    0.0000 C   0  0
   -6.4923   -3.7525    0.0000 C   0  0
   -6.4900   -5.2525    0.0000 O   0  0
   -5.1945   -3.0005    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 13 15  2  0
 15  9  1  0
  8 16  1  0
 16 17  2  0
 17 18  1  0
 18  6  1  0
 18 19  2  0
 19  2  1  0
 16 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 26 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28509

> <plate>
Kinase v5-2

> <well>
E12

> <supplier_cmpd_name>
TG100-115

> <ctcr_id>
1500

> <supplier_cmpd_id>
S1352

> <smiles>
Nc1nc(N)c2nc(c3cccc(O)c3)c(nc2n1)c4cccc(O)c4

> <pd_targets>
{PIK3CA,PIK3CB,PIK3CD,AAK1,COQ8A,DYRK1A,MAP3K7,PIK3CG,EGFR,TNNI3K,ABL1,BRSK1,TYK2,STK16,PRKD3,MKNK2,CSNK1G1,TTK,MAP2K4,BRAF,CLK2,CSNK1A1,BRSK2,SRPK3,MAP3K19,CSNK1D,PTK6,RIOK1,CSNK1A1L,CLK1,ERBB2,LATS2
,GRK4,SRPK1,CSNK1G3,NEK1,PI4KB,PIK3C2G,MTOR,CSNK2A2,ERBB4,JAK1,MAP2K3,RPS6KA1,DYRK2,TAOK3,BMP2K,RIOK2,RIPK4,TAOK1,DYRK1B,RIPK2,MKNK1,CSNK1G2,PIP4K2B,LCK,CLK3,LATS1,RPS6KA6,CLK4,GAK,PIP4K2C,CSNK1E,PIP5
K1C,TRPM6,PIP5K1A,CSNK2A1,PIK3C2B,COQ8B,OXSR1}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Transferase,Kinase,"Voltage-gated ion channel","Protein Kinase","Transient receptor potential channel","Other protein kinase group","Atypical protein kinase group","CMGC protein 
kinase group","TKL protein kinase group","TK protein kinase group","CAMK protein kinase group","CK1 protein kinase group","STE protein kinase group","AGC protein kinase group","Other protein kinase NA
K family","CMGC protein kinase DYRK family","TKL protein kinase MLK family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Abl family","CAMK protein kinase CAMK1 family","Tyrosine prot
ein kinase JakA family","CAMK protein kinase PKD family","CAMK protein kinase MAPKAPK family","CK1 protein kinase CK1 family","Other protein kinase TTK family","STE protein kinase STE7 family","TKL pr
otein kinase RAF family","CMGC protein kinase CLK family","CMGC protein kinase SRPK family","STE protein kinase STE11 family","Tyrosine protein kinase Src family","Atypical protein kinase RIO family",
"AGC protein kinase NDR family","AGC protein kinase GRK family","Other protein kinase NEK family","Atypical protein kinase PIKK family","Other protein kinase CK2 family","AGC protein kinase RSK family
","STE protein kinase STE20 family","TKL protein kinase RIPK family","Atypical protein kinase ABC1 family","CMGC protein kinase Dyrk1 subfamily","TKL protein kinase TAK1 subfamily","TKL protein kinase
 HH498 subfamily","CAMK protein kinase BRSK subfamily","CAMK protein kinase MNK subfamily","Atypical protein kinase RIO1 subfamily","CK1 protein kinase CK1-a","AGC protein kinase GRK subfamily","CK1 p
rotein kinase CK1-g","Atypical protein kinase FRAP subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase Dyrk2 subfamily","STE protein kinase TAO subfamily","Atypical protein kinase RIO2 
subfamily","Atypical protein kinase ABC1-A subfamily","STE protein kinase FRAY subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","Receptor kinases",Atypical,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependen
t protein kinases","CK1: Casein kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families",Phosphatidylinositol-4,"5-bisphosphate 3-kinase 
family","Other protein kinases","ABC1 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","CAMK-like (CAMKL) family
","Protein kinase D (PKD) family","MAPK-Activated Protein Kinase (MAPKAPK) family","Casein kinase 1 (CK1) family","STE7 family","CLK family","SRPK family","STE20 family","RIO family","NDR family","G p
rotein-coupled receptor kinases (GRKs)","1-phosphatidylinositol 4-kinase family","Phosphatidylinositol-4-phosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","RSK
 family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","Alpha kinase family","NAK family","ABC1-B
 subfamily","Dyrk1 subfamily","Mixed Lineage Kinase (MLK) family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","BRSK subfamily","MKN subfamily","TTK family","RAF family",
"STE20 subfamily","RIO1 subfamily","GRK4 subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","FRAP subfamily","Casein kinase 2 (CK2) family","RSK subfamily","Dyrk2 subfamily","TAO
 subfamily","Numb-associated kinase (NAK) family","RIO2 subfamily","Receptor interacting protein kinase (RIPK) family","ChaK subfamily","FRAY subfamily","TAK1 subfamily","Type I RTKs: ErbB (epidermal 
growth factor) receptor family","HH498 subfamily","Abl family","Janus kinase (JakA) family","Src family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Immune System","Vesicle-mediated transport","Cell Cycle",Metabolism,"Metabolism of RNA","Developmental Biology","Gene expression (Transcription)","Neuronal System","Tra
nsport of small molecules","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","Cytokine Signaling in Immune system","Membrane T
rafficking",Mitotic,"Innate Immune System","Metabolism of lipids","Signaling by GPCR","Infectious disease","rRNA processing","Nervous system development","Signaling by Hippo","RNA Polymerase II Transc
ription","Transmission across Chemical Synapses","Ion channel transport","Signaling by FGFR in disease","Signaling by Insulin receptor","Signaling by Interleukins","Clathrin-mediated endocytosis","Mit
otic G1 phase and G1/S transition","Toll-like Receptor Cascades","Phospholipid metabolism","GPCR downstream signalling","Leishmania infection","Interferon Signaling","Sphingolipid metabolism","Signali
ng by NTRKs","Signaling by WNT in cancer","Mitotic G2-G2/M phases","rRNA processing in the nucleus and cytosol","Axon guidance","Generic Transcription Pathway","Neurotransmitter receptors and postsyna
ptic signal transmission","M Phase","Signaling by FGFR","HIV Infection","trans-Golgi Network Vesicle Budding","Stimuli-sensing channels","Signaling by FGFR1 in disease","Insulin receptor signalling ca
scade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Cargo recognition for clathrin-mediated endocytosis","G0 and Early G1","Toll Like Receptor 4 (TLR4) Cascade","PI Metabolism","G alpha (q) sig
nalling events","Parasite infection","Interferon alpha/beta signaling","Sphingolipid de novo biosynthesis","Toll Like Receptor 5 (TLR5) Cascade","Signaling by NTRK1 (TRKA)","Signaling by AMER1 mutants
","G2/M Transition","G1 Phase","Major pathway of rRNA processing in the nucleolus and cytosol","Semaphorin interactions","G alpha (i) signalling events","Transcriptional Regulation by TP53","Activatio
n of NMDA receptors and postsynaptic events","Antiviral mechanism by IFN-stimulated genes","Mitotic Metaphase and Anaphase","Signaling by FGFR4","Host Interactions of HIV factors","Golgi Associated Ve
sicle Biogenesis","TRP channels","FGFR1 mutant receptor activation","IRS-mediated signalling","Interleukin receptor SHC signaling","MyD88-independent TLR4 cascade","Synthesis of PIPs at the plasma mem
brane","Gastrin-CREB signalling pathway via PKC and MAPK","Leishmania phagocytosis","Regulation of IFNA signaling","MyD88 cascade initiated on plasma membrane","Signalling to ERKs","Truncations of AME
R1 destabilize the destruction complex","Centrosome maturation","Cyclin D associated events in G1","Sema4D in semaphorin signaling","Visual phototransduction","Synthesis of PIPs at the Golgi membrane"
,"Regulation of TP53 Activity","Post NMDA receptor activation events","ISG15 antiviral mechanism","Mitotic Anaphase","Negative regulation of FGFR4 signaling","The role of Nef in HIV-1 replication and 
disease pathogenesis","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","TRIF(TICAM1)-mediated TLR4 signaling","EGFR Tran
sactivation by Gastrin","FCGR3A-mediated phagocytosis","MAP kinase activation","Prolonged ERK activation events","Loss of proteins required for interphase microtubule organization from the centrosome"
,"Sema4D induced cell migration and growth-cone collapse","The phototransduction cascade","Regulation of TP53 Expression and Degradation","Regulation of TP53 Activity through Phosphorylation","Long-te
rm potentiation","Separation of Sister Chromatids","Spry regulation of FGF signaling","Regulation of TP53 Activity through Acetylation","Nef-mediates down modulation of cell surface receptors by recru
iting them to clathrin adapters","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","TRAF6-mediated induction of TAK1 complex within TLR4 complex","JNK (c-Jun kinases) 
phosphorylation and  activation mediated by activated human TAK1","ARMS-mediated activation","Loss of Nlp from mitotic centrosomes",Inactivation,"recovery and regulation of the phototransduction casca
de","Regulation of TP53 Degradation","activated TAK1 mediates p38 MAPK activation","MAPK targets/ Nuclear events mediated by MAP kinases","PI5P Regulates TP53 Acetylation","Nef Mediated CD4 Down-regul
ation","RSK activation","CREB phosphorylation"}

> <broad_targets>
{PIK3CA,PIK3CB,PIK3CD,PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{G10011,TG100-115,TG100115,677297-51-7,677297517,TG-100115,"3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol","3,3'(2,4diaminopteridine6,7diyl)diphenol","3,3'-(2,4-DIAMINO-6,7-PTERIDINEDIYL)BISPHENOL","3,
3'(2,4DIAMINO6,7PTERIDINEDIYL)BISPHENOL","6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine","6,7Bis(3hydroxyphenyl)pteridine2,4diamine","3-(2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl)phenol","3(2,4diam
ino7(3hydroxyphenyl)pteridin6yl)phenol",TG-100-115,UN,T2672,S1352}

> <pdid>
PD003378

> <targets>
{NULL,PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{10427712}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    2.6030   -2.9977    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    5.2003   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    7.7985   -1.4932    0.0000 C   0  0
    7.7985   -2.9932    0.0000 C   0  0
    6.4995   -3.7432    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 N   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 C   0  0
   -1.2942   -8.2509    0.0000 O   0  0
    0.0036   -7.4988    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  2 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 10  1  0
 20 14  1  0
 18 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 12 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28510

> <plate>
Kinase v5-2

> <well>
E14

> <supplier_cmpd_name>
TGX-221

> <ctcr_id>
2097

> <supplier_cmpd_id>
S1169

> <smiles>
CC(Nc1ccccc1)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C

> <pd_targets>
{PIK3CB,CLK4,PIK3CA,PIK3CD,CSNK1A1,PTK2,PIK3CG}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","CMGC protein kinase group","CK1 protein kinase group","TK protein kinase group","CMGC protein kinase CLK family","CK1 protein kinase CK1 family","Tyrosine 
protein kinase Fak family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","Receptor kinases",Phosphatidylinositol
-4,"5-bisphosphate 3-kinase family","CLK family","Casein kinase 1 (CK1) family","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Fak family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System",Metabolism,"Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signalin
g in Immune system","Infectious disease","Metabolism of lipids","Signaling by Insulin receptor","Signaling by FGFR in disease","Signaling by Interleukins","Signaling by WNT in cancer","Leishmania infe
ction","Phospholipid metabolism","Insulin receptor signalling cascade","Signaling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Signaling by AMER1 mutants","Parasite infecti
on","PI Metabolism","IRS-mediated signalling","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","Truncations of AMER1 destabilize the destruction complex","Leishmania phagocytosi
s","Synthesis of PIPs at the plasma membrane","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","FCGR3A-mediated phagocytosis"}

> <broad_targets>
{PIK3CB,PIK3CD}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{GX22,TGX-221,TGX221,663619-89-4,663619894,"Tgx 221",CHEMBL1972466,"9-(1-Anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido(1,2-a)pyrimidin-4-one","9(1Anilinoethyl)7methyl2morpholin4ylpyrido(1,2a)pyrimidin
4one",Kinome_3610,Kinome3610,Kinome-3610,"Kinome 3610",PubChem22489,cc-494,cc494,MLS006010987,SCHEMBL902952,GTPL8244,CHEBI:91428,AOB3924,QCR-207,QCR207,SYN1089,BCPP000046,HMS322,T2661,S1169,"EMD 52811
3",528113,"TGX 221"}

> <pdid>
PD003688

> <targets>
{TGX221,TGX-221,"PI3K BETA","PI 3-K? Inhibitor VI"}

> <classes>
{}

> <pubchem_cids>
{9907093}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 40  0  0  0  0            999 V2000
    7.8125   -5.9872    0.0000 C   0  0
    9.1087   -5.2323    0.0000 O   0  0
    7.8187   -7.4880    0.0000 C   0  0
    7.8242   -8.9880    0.0000 C   0  0
    6.5226   -8.2430    0.0000 C   0  0
    9.1204   -8.2335    0.0000 N   0  0
    6.5102   -5.2414    0.0000 N   0  0
    6.5040   -3.7405    0.0000 C   0  0
    5.2034   -2.9932    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    6.4978   -0.7405    0.0000 C   0  0
    7.7984   -1.4879    0.0000 C   0  0
    7.8015   -2.9878    0.0000 C   0  0
    3.8990   -0.7455    0.0000 S   0  0
    3.8964    0.7545    0.0000 O   0  0
    2.5988    0.0025    0.0000 O   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -5.1977   -2.9829    0.0000 O   0  0
   -5.1903   -1.4829    0.0000 C   0  0
   -0.0128   -6.0039    0.0000 Cl  0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
  1  2  2  0
  1  3  1  0
  3  4  1  0
  3  5  1  0
  3  6  1  0
  1  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 10 14  1  0
 14 15  2  0
 14 16  2  0
 14 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 29 31  1  0
 31 32  1  0
 26 33  1  0
 21 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28511

> <plate>
Kinase v5-2

> <well>
E16

> <supplier_cmpd_name>
XL147

> <ctcr_id>
11405

> <supplier_cmpd_id>
S1118

> <smiles>
C(=O)(C(C)(C)N)Nc1cc(ccc1)S(=O)(=O)Nc1nc2c(nc1Nc1c(ccc(c1)OC)Cl)cccc2

> <pd_targets>
{PIK3CB,PIK3CA,PIK3CG,PIK3C3,PIK3CD,PRKDC,PIK3R1,PIK3R2,PIK3R3,PIK3R5}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidylinositol 3-kinase family","Phosphatidyl inositol 3' kinase-relat
ed kinases (PIKK) family","Other PIKK family kinases"}

> <pathway_reactome>
{"Signal Transduction",Disease,Metabolism,"Immune System","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lip
ids","Cytokine Signaling in Immune system","Innate Immune System","Signaling by Insulin receptor","Signaling by FGFR in disease","Phospholipid metabolism","Signaling by Interleukins","Cytosolic sensor
s of pathogen-associated DNA","Insulin receptor signalling cascade","Signaling by FGFR1 in disease","PI Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","STING mediated induction of host
 immune responses","IRS-mediated signalling","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membrane","Interleukin receptor SHC signaling","IRF3-mediated induction of type I IFN",
"PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
{}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{Pilaralisib,934526-89-3,934526893,XL-147,XL147,SAR-245408,SAR245408,"Pilaralisib (XL147)",UNII-60ES45KTMK,UNII60ES45KTMK,60ES45KTMK,"Pilaralisib (USAN:INN)","Pilaralisib, SAR245408",SCHEMBL189422,CHE
MBL3360203,SCHEMBL14921345,SCHEMBL16154579,EX-A196,EXA196,AMY10846,BCP15312,BDBM50197062,MFC,T2365}

> <pdid>
PD012456

> <targets>
{PI3K,PI3K¦Á,PI3K¦Â,PI3K¦Ã,PI3K¦Ä}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{56599306}

$$$$
UTKinase_V5
  SciTegic11012413002D

 43 47  0  0  0  0            999 V2000
    9.0964   -0.7233    0.0000 C   0  0
    7.8010   -1.4797    0.0000 O   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 S   0  0
   -2.6016   -2.9971    0.0000 O   0  0
   -1.3015   -2.2494    0.0000 O   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -0.0095   -6.0029    0.0000 C   0  0
   -0.0126   -7.5029    0.0000 C   0  0
   -1.3132   -8.2502    0.0000 C   0  0
   -1.3193   -9.7510    0.0000 N   0  0
   -2.6217  -10.4969    0.0000 C   0  0
   -3.9179   -9.7420    0.0000 O   0  0
   -2.6279  -11.9977    0.0000 C   0  0
   -3.9284  -12.7451    0.0000 C   0  0
   -3.9316  -14.2451    0.0000 C   0  0
   -2.6341  -14.9978    0.0000 C   0  0
   -2.6372  -16.4978    0.0000 C   0  0
   -1.3335  -14.2505    0.0000 C   0  0
   -0.0337  -15.0010    0.0000 O   0  0
    1.2658  -14.2518    0.0000 C   0  0
   -1.3304  -12.7505    0.0000 C   0  0
   -2.6106   -7.4975    0.0000 C   0  0
   -2.6076   -5.9975    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    5.1882    3.0099    0.0000 O   0  0
    6.4857    3.7625    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 14 15  1  0
 15 16  2  0
 16  7  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 18 20  2  0
 18 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 31 33  1  0
 33 34  1  0
 34 35  1  0
 33 36  2  0
 36 28  1  0
 24 37  1  0
 37 38  2  0
 38 21  1  0
  5 39  2  0
 39 40  1  0
 40 41  1  0
 41 42  1  0
 40 43  2  0
 43  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28512

> <plate>
Kinase v5-2

> <well>
E18

> <supplier_cmpd_name>
XL765

> <ctcr_id>
3041

> <supplier_cmpd_id>
S1523

> <smiles>
COc1cc(Nc2nc3ccccc3nc2NS(=O)(=O)c4ccc(NC(=O)c5ccc(C)c(OC)c5)cc4)cc(OC)c1

> <pd_targets>
{PIK3CD,MTOR,PRKDC,PIK3CA,MLST8,RPTOR,PIK3CB,PIK3CG}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfami
ly","Other PIKK family kinases"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)",Disease,"Signal Transduction",Metabolism,"Cytokine Signaling in Immune system","RNA Polymerase II Transcription","Innate Immune System","Diseases of 
signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","Signaling by Interleukins","Generic Transcription Pathway","Cytos
olic sensors of pathogen-associated DNA","Signaling by FGFR in disease","Signaling by Insulin receptor","Phospholipid metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Transcriptional Re
gulation by TP53","STING mediated induction of host immune responses","Signaling by FGFR1 in disease","Insulin receptor signalling cascade","PI Metabolism","Interleukin receptor SHC signaling","Regula
tion of TP53 Activity","IRF3-mediated induction of type I IFN","FGFR1 mutant receptor activation","IRS-mediated signalling","Synthesis of PIPs at the plasma membrane","Regulation of TP53 Expression an
d Degradation","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR,PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{NSC-768100,NSC768100,NSC-800992,NSC800992,"Voxtalisib (SAR245409, XL765)",XL765,1349796-36-6,1349796366,1123889-87-1,1123889871,XL-765,PI3K-IN-1,PI3KIN1,"Voxtalisib Analogue","XL 765","SAR245409 (XL7
65)",Voxtalisib-Analog,VoxtalisibAnalog,CHEBI:71958,"Exelixis pI3K inhibitor","XL-147 derivative 1","XL147 derivative 1",CS-,CS,T1826,S1523}

> <pdid>
PD003336

> <targets>
{PI3K,mTOR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{49867926}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    4.0551   -4.4171    0.0000 F   0  0
    2.5551   -4.4192    0.0000 C   0  0
    1.8073   -5.7196    0.0000 F   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1743   -3.8808    0.0000 N   0  0
   -3.0913   -5.0679    0.0000 C   0  0
   -2.5218   -6.4556    0.0000 N   0  0
   -1.0353   -6.6562    0.0000 C   0  0
   -0.1183   -5.4691    0.0000 N   0  0
   -0.4655   -8.0446    0.0000 N   0  0
   -1.3806   -9.2332    0.0000 C   0  0
   -0.8088  -10.6200    0.0000 C   0  0
    0.6780  -10.8182    0.0000 O   0  0
    1.5931   -9.6297    0.0000 C   0  0
    1.0214   -8.2429    0.0000 C   0  0
   -4.5786   -4.8672    0.0000 N   0  0
   -5.1504   -3.4804    0.0000 C   0  0
   -6.6373   -3.2821    0.0000 C   0  0
   -7.5524   -4.4706    0.0000 O   0  0
   -6.9807   -5.8574    0.0000 C   0  0
   -5.4938   -6.0557    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
 12  4  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 19  1  0
 15 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28513

> <plate>
Kinase v5-2

> <well>
E20

> <supplier_cmpd_name>
ZSTK474

> <ctcr_id>
2959

> <supplier_cmpd_id>
S1072

> <smiles>
FC(F)c1nc2ccccc2n1c3nc(nc(n3)N4CCOCC4)N5CCOCC5

> <pd_targets>
{PIK3CB,PIK3CG,PIK3CA,PIK3C2B,PIK3CD,PIK3R1,MTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidylinositol-4-phosphate 3-kinase family","Phosphatidyl inositol 3' 
kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,Disease,"Gene expression (Transcription)","Immune System","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","Diseases of signal transduction by growth f
actor receptors and second messengers","RNA Polymerase II Transcription","Cytokine Signaling in Immune system","Signaling by Insulin receptor","Phospholipid metabolism","Signaling by FGFR in disease",
"Generic Transcription Pathway","Signaling by Interleukins","Insulin receptor signalling cascade","PI Metabolism","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53",Interleukin-3,"In
terleukin-5 and GM-CSF signaling","IRS-mediated signalling","Synthesis of PIPs at the plasma membrane","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Interleukin receptor SHC signal
ing","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{PIK3CB,PIK3CD,PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{ZSTK474,475110-96-4,475110964,ZSTK-474,"ZSTK 474",TCMDC-137004,TCMDC137004,UNII-K0068GK39A,UNIIK0068GK39A,"2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazine","2(2Difluoromethyl
benzimidazol1yl)4,6bis(morpholino)1,3,5triazine",CHEMBL586702,CHEBI:90545,K0068GK39A,2-(2-difluoromethylbenzimidazol-1-yl)-4,2(2difluoromethylbenzimidazol1yl)4,6-dimorpholino-1,6dimorpholino1,3,5-tria
z,5triaz,T6168,S1072}

> <pdid>
PD003388

> <targets>
{PI3K,Autophagy}

> <classes>
{Autophagy,PI3K/Akt/mTOR}

> <pubchem_cids>
{11647372}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 N   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.8193    4.6606    0.0000 C   0  0
   -4.0353    5.9336    0.0000 C   0  0
   -4.7489    7.2530    0.0000 C   0  0
   -6.2483    7.2947    0.0000 N   0  0
   -7.0341    6.0170    0.0000 C   0  0
   -6.3205    4.6976    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -6.4469    1.8311    0.0000 C   0  0
   -7.4153    2.9701    0.0000 C   0  0
   -8.8906    2.6991    0.0000 C   0  0
   -9.3937    1.2860    0.0000 C   0  0
  -10.8690    1.0150    0.0000 F   0  0
   -8.4213    0.1438    0.0000 C   0  0
   -6.9460    0.4147    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 10 17  2  0
 17 18  1  0
 18  8  2  0
 17 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28514

> <plate>
Kinase v5-2

> <well>
E22

> <supplier_cmpd_name>
SB 202190

> <ctcr_id>
90

> <supplier_cmpd_id>
S1077

> <smiles>
Oc1ccc(cc1)c2[nH]c(c3ccncc3)c(n2)c4ccc(F)cc4

> <pd_targets>
{EGFR,MAPK11,MAPK14,ALDH1A1,HPGD,CYP2C9,CSNK1A1,MAPK10,RIPK2,TNIK,LEF,AMPC,BRD4,BRDT,TUBA1A,PRKACA,MAPK8,BRAF,CIT,CSNK1E,MAPK12,RPS6KA1,MAPK1,ACVR1B,GSK3B,MAPK9,RAF1,GAK,PRKACB,MAP2K2,ACVR2B,COQ8B,TSH
R,ROS1,HSD17B10,KDM4E,FRK,STK36,PTK6,MAPT,BLM,TTK,CYP2C19,THPO,CDC42BPG,EPHA7,RPS6KA6,STK32B,HTR2A,ERBB4,CSNK1A1L,NTRK3,CYP2D6,CYP3A4,LATS2,IGF1R,DDR1,DDR2,SLK,NLK,CSNK1D,NTRK2,GMNN,CYP1A2,TTBK1,LMNA,
NFKB1,EPHA6,MAPK13,CDC42BPB,TTBK2,ALOX5,CLK4,PRKD3,NFO,PMP22,ALOX15,MAP4K4,GCGR,TYR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Structural protein","Membrane receptor","Other cytosolic protein","Unclassified protein","Other nuclear protein",Kinase,Oxidoreductase,"Cytochrome P450",Protease,Hydrol
ase,Reader,"Family A G protein-coupled receptor",Eraser,"Family B G protein-coupled receptor","Protein Kinase","Cytochrome P450 family 2","Metallo protease",Bromodomain,"Peptide receptor (family A GPC
R)","Lysine demethylase","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 1","Peptide receptor (family B GPCR)","TK protein kinase group","CMGC protein kina
se group","Cytochrome P450 family 2C","CK1 protein kinase group","TKL protein kinase group","STE protein kinase group","Metallo protease MAE clan","AGC protein kinase group","Other protein kinase grou
p","Atypical protein kinase group","Glycohormone receptor","Jumonji domain-containing","Monoamine receptor","Cytochrome P450 family 2D","Cytochrome P450 family 3A","Cytochrome P450 family 1A","CAMK pr
otein kinase group","Glucagon-like receptor","Tyrosine protein kinase EGFR family","CMGC protein kinase MAPK family","Cytochrome P450 2C9","CK1 protein kinase CK1 family","TKL protein kinase RIPK fami
ly","STE protein kinase STE20 family","Metallo protease M34 family","AGC protein kinase PKA family","TKL protein kinase RAF family","AGC protein kinase DMPK family","AGC protein kinase RSK family","TK
L protein kinase STKR family","CMGC protein kinase GSK family","Other protein kinase NAK family","STE protein kinase STE7 family","Atypical protein kinase ABC1 family","Tyrosine protein kinase Sev fam
ily","Tyrosine protein kinase Src family","Other protein kinase ULK family","Other protein kinase TTK family","Cytochrome P450 2C19","Tyrosine protein kinase Eph family","AGC protein kinase YANK famil
y","Serotonin receptor","Tyrosine protein kinase Trk family","Cytochrome P450 2D6","Cytochrome P450 3A4","AGC protein kinase NDR family","Tyrosine protein kinase InsR family","Tyrosine protein kinase 
DDR family","Cytochrome P450 1A1","CMGC protein kinase CLK family","CAMK protein kinase PKD family","Glucagon receptor","CMGC protein kinase p38 subfamily","CMGC protein kinase JNK subfamily","STE pro
tein kinase MSN subfamily","AGC protein kinase CRIK subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase ERK1","TKL protein kinase STKR Type 1 subfamily","TKL protein kinase STKR Type 2 
subfamily","Atypical protein kinase ABC1-A subfamily","AGC protein kinase GEK subfamily","CK1 protein kinase CK1-a","STE protein kinase SLK subfamily","CMGC protein kinase nmo subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Eicosanoid turnover","Cytochrome P450","Chromatin modifying enzymes","Bromodomain-containing proteins",Tubulins
,"G protein-coupled receptors","1.-.-.- Oxidoreductases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Prostaglandin synthases","CYP2 family: drug metabolising subset","CK1: Case
in kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Enzymatic bromodomain-containing proteins","Non-enzymatic BRD containing proteins","AGC: Containing PKA",PKG,"PKC fam
ilies",Atypical,"Glycoprotein hormone receptors","1.14.11.- Histone demethylases","5-Hydroxytryptamine receptors","CYP3 family","CYP1 family",Lipoxygenases,"CAMK: Calcium/calmodulin-dependent protein 
kinases","Glucagon receptor family","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Casein kinase 1 (CK1) family","TKL: Tyrosine kinase-like","STE20 family","Bromodomain kinas
e (BRDK) family","Protein kinase A (PKA) family","DMPK family","RSK family","Glycogen synthase kinase (GSK) family","Other protein kinases","STE7 family","ABC1 family","YANK family","NDR family","Tau 
tubulin kinase (TTBK) family","CLK family","Protein kinase D (PKD) family","Receptor tyrosine kinases (RTKs)","p38 subfamily","JNK subfamily","Receptor interacting protein kinase (RIPK) family","MSN s
ubfamily","RAF family","Other DMPK family kinases","RSK subfamily","ERK subfamily","Receptor serine/threonine kinase (RSTK) family","GSK subfamily","Numb-associated kinase (NAK) family","ABC1-B subfam
ily","Non-receptor tyrosine kinases (nRTKs)","Unc-51-like kinase (ULK) family","TTK family","GEK subfamily","SLK subfamily","nmo subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family
","Type I receptor serine/threonine kinases","Type II receptor serine/threonine kinases","Type XVII RTKs: ROS receptors","Src family","Type XIII RTKs: Ephrin receptor family","Type VII RTKs: Neurotrop
hin receptor/Trk family","Type II RTKs: Insulin receptor family","Type XVI RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Metabolism,Disease,"Cellular responses to external stimuli","Cell Cycle","Developmental Biology","Vesicle-mediated transport","Neuronal System","DNA Repair",Hemo
stasis,"Extracellular matrix organization","Organelle biogenesis and maintenance","Signaling by GPCR","Innate Immune System","Biological oxidations","Metabolism of lipids","Diseases of signal transduc
tion by growth factor receptors and second messengers","Cellular responses to stress","Infectious disease",Mitotic,"Signaling by Receptor Tyrosine Kinases","Signaling by Rho GTPases","Signaling by NOD
AL","MAPK family signaling cascades","Membrane Trafficking","Intracellular signaling by second messengers","Metabolism of amino acids and derivatives","Transmission across Chemical Synapses","DNA Doub
le-Strand Break Repair","Platelet activation","signaling and aggregation","Nervous system development","Signaling by Hippo","Non-integrin membrane-ECM interactions","Signaling by WNT","Cytokine Signal
ing in Immune system","Cilium Assembly","GPCR downstream signalling","Toll-like Receptor Cascades","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)
","Signaling by WNT in cancer","Cellular Senescence","Uptake and actions of bacterial toxins","SARS-CoV Infections","Mitotic G2-G2/M phases","Signaling by NTRKs","RHO GTPase Effectors","Regulation of 
signaling by NODAL","MAPK1/MAPK3 signaling","trans-Golgi Network Vesicle Budding","DAG and IP3 signaling","Leishmania infection","Branched-chain amino acid catabolism","PIP3 activates AKT signaling","
Mitotic G1 phase and G1/S transition","Neurotransmitter receptors and postsynaptic signal transmission","Homology Directed Repair","Platelet Aggregation (Plug Formation)","Axon guidance","GPCR ligand 
binding","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Beta-catenin independent WNT signaling","M Phase","Signaling by Interleukins","Anchoring of the basal body to the plasma m
embrane","Sphingolipid metabolism","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Melanin biosynthesis","G alpha (q) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Ethano
l oxidation","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Signaling by AMER1 mutants","Oxidative Stress Induced Senescence","Uptake and function of anthrax toxins
","Potential therapeutics for SARS","G2/M Transition","Signaling by NTRK1 (TRKA)","RHO GTPases activate CIT","SARS-CoV-1 Infection","RAF/MAP kinase cascade","Golgi Associated Vesicle Biogenesis","CaM 
pathway","Leishmania parasite growth and survival","PTEN Regulation","G1 Phase","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Anne
aling (SSA)","EPH-Ephrin signaling","Class A/1 (Rhodopsin-like receptors)","Signaling by NTRK3 (TRKC)","IGF1R signaling cascade","Ca2+ pathway","G1/S Transition","Mitotic Metaphase and Anaphase","Inte
rleukin-1 family signaling","Biosynthesis of DPA-derived SPMs","Sphingolipid de novo biosynthesis","Gastrin-CREB signalling pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Bios
ynthesis of D-series resolvins",Xenobiotics,"Truncations of AMER1 destabilize the destruction complex","Centrosome maturation","Signalling to ERKs","SARS-CoV-1 Genome Replication and Transcription","N
egative regulation of MAPK pathway","Calmodulin induced events","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of PTEN stability and activity","Cyclin D associated ev
ents in G1","Post NMDA receptor activation events","HDR through Homologous Recombination (HRR)","EPHA-mediated growth cone collapse","Amine ligand-binding receptors","Activated NTRK3 signals through P
I3K","Biosynthesis of maresins","IRS-related events triggered by IGF1R","Activation of TRKA receptors","Activation of the pre-replicative complex","Mitotic Anaphase","Interleukin-1 signaling","Biosynt
hesis of DPAn-3 SPMs","EGFR Transactivation by Gastrin","MAP kinase activation","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","Prolonged ER
K activation events","Signalling to RAS","Replication of the SARS-CoV-1 genome","Negative feedback regulation of MAPK pathway","PKA-mediated phosphorylation of CREB","ADORA2B mediated anti-inflammator
y cytokines production","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Serot
onin receptors","Long-term potentiation","Biosynthesis of maresin-like SPMs","NGF-independant TRKA activation","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Nuclear Envelope (NE)
 Reassembly","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of DPAn-3-derived 13-series resolvins","Biosynthesis of DPAn-3-derived protectins and resolvins","MAPK targets/ Nuclear events m
ediated by MAP kinases","activated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","ARMS-mediated activation","p38MAPK events","PKA activation","Frs2-mediated activation","Pr
esynaptic phase of homologous DNA pairing and strand exchange","RSK activation","Initiation of Nuclear Envelope (NE) Reformation","Activation of the AP-1 family of transcription factors","CREB phospho
rylation","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{AKT1,ALOX5,CHEK1,GSK3B,LCK,MAPK1,MAPK11,MAPK12,MAPK14,MAPK8,PRKCA,ROCK1,RPS6KB1,SGK1}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"SB 202190",152121-30-7,152121307,SB-202190,SB202190,FHPI,"SB202190 (FHPI)",4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole,4(4Fluorophenyl)2(4hydroxyphenyl)5(4pyridyl)1Himidazole,U
NII-PVX798P8GI,UNIIPVX798P8GI,4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole,4(4fluorophenyl)2(4hydroxyphenyl)5(4pyridyl)imidazole,CHEBI:79090,4-(4-(4-fluorophenyl),4(4(4fluorophenyl),T
2301,"EMD 559388",1264,EI-294,S1077,559388}

> <pdid>
PD002796

> <targets>
{"p38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{5169}

$$$$
UTKinase_V5
  SciTegic11012413002D

 68 71  0  0  1  0            999 V2000
    6.9056    4.5744    0.0000 C   0  0
    6.6527    6.0529    0.0000 O   0  0
    5.2453    6.5743    0.0000 C   0  0  2  0  0  0
    4.0927    5.6144    0.0000 C   0  0
    2.6850    6.1326    0.0000 C   0  0  1  0  0  0
    2.4301    7.6108    0.0000 C   0  0
    3.5827    8.5707    0.0000 C   0  0
    4.9903    8.0525    0.0000 C   0  0  1  0  0  0
    6.1416    9.0153    0.0000 O   0  0
    5.8843   10.4939    0.0000 C   0  0
    7.0356   11.4568    0.0000 C   0  0
    6.7785   12.9346    0.0000 O   0  0
    1.5337    5.1698    0.0000 C   0  0
    1.7909    3.6911    0.0000 C   0  0  2  0  0  0
    3.1995    3.1753    0.0000 C   0  0
    0.6400    2.7300    0.0000 C   0  0  2  0  0  0
    0.8000    1.1200    0.0000 C   0  0
    2.0600    0.3500    0.0000 C   0  0
    1.8870   -1.1400    0.0000 O   0  0
    3.4300    0.8000    0.0000 C   0  0  2  0  0  0
    3.8662    2.2352    0.0000 C   0  0
    4.3600   -0.3900    0.0000 C   0  0
    5.8000   -0.4000    0.0000 C   0  0
    6.6151    0.8592    0.0000 C   0  0
    6.4400   -1.8000    0.0000 C   0  0  1  0  0  0
    7.9345   -1.9281    0.0000 O   0  0
    5.5100   -3.1600    0.0000 C   0  0  1  0  0  0
    4.0182   -3.2790    0.0000 O   0  0
    3.1659   -2.0447    0.0000 C   0  0
    6.5100   -4.2800    0.0000 C   0  0
    7.9504   -3.8613    0.0000 O   0  0
    6.2500   -5.8600    0.0000 C   0  0  2  0  0  0
    7.5042   -6.6827    0.0000 C   0  0
    4.8700   -6.7500    0.0000 C   0  0
    3.3400   -6.2300    0.0000 C   0  0  2  0  0  0
    2.3025   -7.3134    0.0000 C   0  0
    2.7800   -4.7900    0.0000 C   0  0
    1.1200   -4.8600    0.0000 C   0  0
    0.1200   -3.6900    0.0000 C   0  0
   -1.4100   -4.1500    0.0000 C   0  0
   -2.6300   -3.1700    0.0000 C   0  0
   -4.1200   -3.7800    0.0000 C   0  0
   -4.3154   -5.2672    0.0000 C   0  0
   -5.3700   -2.8300    0.0000 C   0  0  2  0  0  0
   -6.8600   -3.4400    0.0000 C   0  0
   -7.8600   -2.2400    0.0000 C   0  0  2  0  0  0
   -9.2500   -2.5000    0.0000 C   0  0
  -10.1800   -1.4400    0.0000 C   0  0
   -9.7100    0.0100    0.0000 C   0  0  1  0  0  0
  -10.7377    1.1027    0.0000 C   0  0
   -8.0800    0.4300    0.0000 C   0  0  1  0  0  0
   -8.4778    1.8763    0.0000 O   0  0
   -7.2300   -0.9300    0.0000 O   0  0
   -6.6100    0.8600    0.0000 C   0  0
   -5.5855   -0.2356    0.0000 O   0  0
   -6.1000    2.2500    0.0000 C   0  0
   -7.0129    3.4402    0.0000 O   0  0
   -4.5400    2.3900    0.0000 N   0  0
   -5.4800    3.8300    0.0000 C   0  0
   -4.8400    5.2900    0.0000 C   0  0
   -3.4600    5.5000    0.0000 C   0  0
   -2.6400    4.4900    0.0000 C   0  0
   -3.1200    3.1200    0.0000 C   0  0  1  0  0  0
   -1.9000    2.2900    0.0000 C   0  0
   -1.8545    0.7907    0.0000 O   0  0
   -0.7100    3.2100    0.0000 O   0  0
   -5.1613   -1.3445    0.0000 O   0  0
   -3.7708   -0.7819    0.0000 C   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  8  9  1  1
  9 10  1  0
 10 11  1  0
 11 12  1  0
  5 13  1  6
 13 14  1  0
 14 15  1  6
 14 16  1  0
 16 17  1  6
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  6
 20 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  1  1
 25 27  1  0
 27 28  1  6
 28 29  1  0
 27 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  1  6
 32 34  1  0
 34 35  1  0
 35 36  1  6
 35 37  1  0
 37 38  2  0
 38 39  1  0
 39 40  2  0
 40 41  1  0
 41 42  2  0
 42 43  1  0
 42 44  1  0
 44 45  1  0
 46 45  1  6
 46 47  1  0
 47 48  1  0
 48 49  1  0
 49 50  1  1
 49 51  1  0
 51 52  1  1
 51 53  1  0
 53 46  1  0
 51 54  1  0
 54 55  2  0
 54 56  1  0
 56 57  2  0
 56 58  1  0
 58 59  1  0
 59 60  1  0
 60 61  1  0
 61 62  1  0
 63 62  1  1
 63 58  1  0
 63 64  1  0
 64 65  2  0
 64 66  1  0
 66 16  1  0
 44 67  1  6
 67 68  1  0
M  END
> <name>
UTKinase_V5

> <id>
28515

> <plate>
Kinase v5-2

> <well>
G04

> <supplier_cmpd_name>
Everolimus(RAD001)

> <ctcr_id>
7086

> <supplier_cmpd_id>
S1120

> <smiles>
CO[C@@H]1C[C@@H](CC[C@H]1OCCO)C[C@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC

> <pd_targets>
{MTOR,ABCC3,ABCB11,ABCC2,ABCC4,KCNE1,KCNQ1,FKBP1A}

> <pathway_gtopdb>
{Enzyme,Transporter,"Ion channel",Kinase,"Primary active transporter","Voltage-gated ion channel",Isomerase,"Protein Kinase","ATP-binding cassette","Potassium channels","Atypical protein kinase group"
,"ABCC subfamily","ABCB subfamily","Voltage-gated potassium channel","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Transporters,"Kinases (EC 2.7.x.x)","ATP-binding cassette transporter family","Peptidyl-prolyl cis/trans isomerases",Atypical,"ABCC subfamily","ABCB subfamily","Phosphatidyl inositol 3' kinas
e-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Metabolism,Disease,Hemostasis,"RNA Polymerase II Transcription","Metabolism of lipids","Disorders of transmembrane transporters","Platelet activation","signaling and
 aggregation","Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","Metabolism of steroids","ABC transporter disorders","Response to eleva
ted platelet cytosolic Ca2+","Signaling by TGF-beta Receptor Complex in Cancer","Transcriptional Regulation by TP53","Bile acid and bile salt metabolism","Defective ABCC2 causes DJS","Platelet degranu
lation","Loss of Function of TGFBR1 in Cancer","Regulation of TP53 Activity","Recycling of bile acids and salts","Synthesis of bile acids and bile salts","TGFBR1 LBD Mutants in Cancer","Regulation of 
TP53 Expression and Degradation","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{159351-69-6,159351696,"Everolimus (RAD001)",S1120,SCHEMBL800003,HMS3884K03,ZINC252467387,CCG-264827,CCG264827,"Everolimus,RAD001, SDZ-RAD, Certican","Everolimus,RAD001, SDZRAD, Certican",S-7708,S7708
,AB01566805_01,AB0156680501,AB01566805-01,"AB01566805 01",Everolimus(RAD001)}

> <pdid>
PD004083

> <targets>
{mTOR}

> <classes>
{}

> <pubchem_cids>
{46930999}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  1  0            999 V2000
    7.7938   -3.0046    0.0000 C   0  0
    6.4946   -3.7543    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    3.8888   -5.2533    0.0000 C   0  0
    2.5875   -5.9994    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0007    0.0000 N   0  0
   -3.8959    3.7529    0.0000 C   0  0
   -3.8936    5.2529    0.0000 C   0  0
   -2.5933    6.0009    0.0000 O   0  0
   -1.2955    5.2488    0.0000 C   0  0
   -1.2979    3.7488    0.0000 C   0  0
   -5.1968   -1.5004    0.0000 N   0  0
   -5.1993   -3.0005    0.0000 C   0  0
   -6.4995   -3.7484    0.0000 C   0  0  2  0  0  0
   -6.5019   -5.2484    0.0000 C   0  0
   -7.7973   -2.9963    0.0000 O   0  0
   -7.7950   -1.4963    0.0000 C   0  0  2  0  0  0
   -9.0928   -0.7443    0.0000 C   0  0
   -6.4947   -0.7484    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
  6 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
 17 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  6
 28 30  1  0
 30 31  1  0
 31 32  1  6
 31 33  1  0
 33 26  1  0
 15 34  2  0
 34 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28516

> <plate>
Kinase v5-2

> <well>
G06

> <supplier_cmpd_name>
KU-0063794

> <ctcr_id>
7122

> <supplier_cmpd_id>
S1226

> <smiles>
COc1ccc(cc1CO)c2ccc3c(nc(nc3N4CCOCC4)N5C[C@H](C)O[C@H](C)C5)n2

> <pd_targets>
{KCNH2,MTOR,PIK3CD,PIK3CA,MLST8,RPTOR,MAPKAP1,RICTOR}

> <pathway_gtopdb>
{"Ion channel",Enzyme,"Voltage-gated ion channel",Kinase,Transferase,"Potassium channels","Protein Kinase","Voltage-gated potassium channel","Atypical protein kinase group","Atypical protein kinase PI
KK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{"Ion channels",Enzymes,"Voltage-gated ion channels","Kinases (EC 2.7.x.x)","Potassium channels",Atypical,"Lipid modifying kinases","Voltage-gated potassium channels","Phosphatidyl inositol 3' kinase-
related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","FRAP subfamily"}

> <pathway_reactome>
{"Muscle contraction","Gene expression (Transcription)","Immune System",Disease,"Cardiac conduction","RNA Polymerase II Transcription","Cytokine Signaling in Immune system","Diseases of signal transdu
ction by growth factor receptors and second messengers","Phase 3 - rapid repolarisation","Generic Transcription Pathway","Signaling by Interleukins","Signaling by FGFR in disease","Transcriptional Reg
ulation by TP53",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Signaling by FGFR1 in disease","Regulation of TP53 Activity","Interleukin receptor SHC signaling","FGFR1 mutant receptor activation
","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{U006379,Ku-0063794,Ku0063794,938440-64-3,938440643,KU0063794,"KU 0063794",KU-63794,KU63794,UNII-81HJG228AB,UNII81HJG228AB,"Ku 63794",81HJG228AB,CHEMBL1078983,CHEBI:85572,C25H31N5O4,Ku63794,PubChem224
75,cc-34,cc34,MLS006011007,SCHEMBL290211,GTPL9360,AMY2729,AOB3533,DTXSID50239782,EX-A045,EXA045,SYN1050,ACT0,S1226,KU-0063794}

> <pdid>
PD003367

> <targets>
{mTOR}

> <classes>
{}

> <pubchem_cids>
{16736978}

$$$$
UTKinase_V5
  SciTegic11012413002D

 65 68  0  0  0  0            999 V2000
    1.9161   10.5654    0.0000 C   0  0
    3.3245   10.0492    0.0000 O   0  0
    3.5827    8.5707    0.0000 C   0  0
    2.4301    7.6108    0.0000 C   0  0
    2.6850    6.1326    0.0000 C   0  0
    4.0927    5.6144    0.0000 C   0  0
    5.2453    6.5743    0.0000 C   0  0
    4.9903    8.0525    0.0000 C   0  0
    6.1429    9.0124    0.0000 O   0  0
    1.5337    5.1698    0.0000 C   0  0
    1.7909    3.6911    0.0000 C   0  0
    3.1995    3.1753    0.0000 C   0  0
    0.6400    2.7300    0.0000 C   0  0
    0.8000    1.1200    0.0000 C   0  0
    2.0600    0.3500    0.0000 C   0  0
    1.8870   -1.1400    0.0000 O   0  0
    3.4300    0.8000    0.0000 C   0  0
    3.8662    2.2352    0.0000 C   0  0
    4.3600   -0.3900    0.0000 C   0  0
    5.8000   -0.4000    0.0000 C   0  0
    6.6151    0.8592    0.0000 C   0  0
    6.4400   -1.8000    0.0000 C   0  0
    7.9345   -1.9281    0.0000 O   0  0
    5.5100   -3.1600    0.0000 C   0  0
    4.0188   -3.2852    0.0000 O   0  0
    3.3799   -4.6424    0.0000 C   0  0
    6.5100   -4.2800    0.0000 C   0  0
    7.9504   -3.8613    0.0000 O   0  0
    6.2500   -5.8600    0.0000 C   0  0
    7.5042   -6.6827    0.0000 C   0  0
    4.8700   -6.7500    0.0000 C   0  0
    3.3400   -6.2300    0.0000 C   0  0
    2.3025   -7.3134    0.0000 C   0  0
    2.7800   -4.7900    0.0000 C   0  0
    1.1200   -4.8600    0.0000 C   0  0
    0.1200   -3.6900    0.0000 C   0  0
   -1.4100   -4.1500    0.0000 C   0  0
   -2.6300   -3.1700    0.0000 C   0  0
   -4.1200   -3.7800    0.0000 C   0  0
   -4.3154   -5.2672    0.0000 C   0  0
   -5.3700   -2.8300    0.0000 C   0  0
   -6.8600   -3.4400    0.0000 C   0  0
   -7.8600   -2.2400    0.0000 C   0  0
   -9.2500   -2.5000    0.0000 C   0  0
  -10.1800   -1.4400    0.0000 C   0  0
   -9.7100    0.0100    0.0000 C   0  0
  -10.7377    1.1027    0.0000 C   0  0
   -8.0800    0.4300    0.0000 C   0  0
   -8.4778    1.8763    0.0000 O   0  0
   -7.2300   -0.9300    0.0000 O   0  0
   -6.6100    0.8600    0.0000 C   0  0
   -5.5855   -0.2356    0.0000 O   0  0
   -6.1000    2.2500    0.0000 C   0  0
   -7.0129    3.4402    0.0000 O   0  0
   -4.5400    2.3900    0.0000 N   0  0
   -5.4800    3.8300    0.0000 C   0  0
   -4.8400    5.2900    0.0000 C   0  0
   -3.4600    5.5000    0.0000 C   0  0
   -2.6400    4.4900    0.0000 C   0  0
   -3.1200    3.1200    0.0000 C   0  0
   -1.9000    2.2900    0.0000 C   0  0
   -1.8545    0.7907    0.0000 O   0  0
   -0.7100    3.2100    0.0000 O   0  0
   -5.1674   -1.3437    0.0000 O   0  0
   -6.3526   -0.4242    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  8  9  1  0
  5 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  2  3
 20 21  1  0
 20 22  1  0
 22 23  1  0
 22 24  1  0
 24 25  1  0
 25 26  1  0
 24 27  1  0
 27 28  2  0
 27 29  1  0
 29 30  1  0
 29 31  1  0
 31 32  1  0
 32 33  1  0
 32 34  1  0
 34 35  2  3
 35 36  1  0
 36 37  2  3
 37 38  1  0
 38 39  2  3
 39 40  1  0
 39 41  1  0
 41 42  1  0
 42 43  1  0
 43 44  1  0
 44 45  1  0
 45 46  1  0
 46 47  1  0
 46 48  1  0
 48 49  1  0
 48 50  1  0
 50 43  1  0
 48 51  1  0
 51 52  2  0
 51 53  1  0
 53 54  2  0
 53 55  1  0
 55 56  1  0
 56 57  1  0
 57 58  1  0
 58 59  1  0
 59 60  1  0
 60 55  1  0
 60 61  1  0
 61 62  2  0
 61 63  1  0
 63 13  1  0
 41 64  1  0
 64 65  1  0
M  END
> <name>
UTKinase_V5

> <id>
28517

> <plate>
Kinase v5-2

> <well>
G08

> <supplier_cmpd_name>
Rapamycin(Sirolimus)

> <ctcr_id>
3116

> <supplier_cmpd_id>
S1039

> <smiles>
COC1CC(CCC1O)CC(C)C2CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C(C)C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC

> <pd_targets>
{FKBP1B,MAPT,FFP,FTL,TGR,RORC,FKBP1A,MTOR,NR1I2,FKBP5,EIF4E,ATP2A1,PDCD4,CYP2C9,CYP3A4,SLCO1B1,ABCB1,CYP2C19,FGF2}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Unclassified protein","Transcription factor","Other nuclear protein",Transporter,"Secreted protein",Isomerase,Transferase,"Nuclear receptor",Kinase,"Primary active t
ransporter","Cytochrome P450","Electrochemical transporter","Nuclear hormone receptor subfamily 1","Protein Kinase","P-type ATPase","Cytochrome P450 family 2","Cytochrome P450 family 3","SLC superfami
ly of solute carriers","ATP-binding cassette","Nuclear hormone receptor subfamily 1 group F","Atypical protein kinase group","Nuclear hormone receptor subfamily 1 group I","Calcium ATPase","Cytochrome
 P450 family 2C","Cytochrome P450 family 3A","SLC21/SLCO family of organic anion transporting polypeptides","ABCB subfamily","Nuclear hormone receptor subfamily 1 group F member 3","Atypical protein k
inase PIKK family","Nuclear hormone receptor subfamily 1 group I member 2","Cytochrome P450 2C9","Cytochrome P450 3A4","Cytochrome P450 2C19","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Nuclear hormone receptors","Peptidyl-prolyl cis/trans isomerases","Kinases (EC 2.7.x.x)","P-type ATPases","Cytochrome P450","SLC superfamily of solute carriers","ATP-b
inding cassette transporter family","1F. Retinoic acid-related orphans",Atypical,"1I. Vitamin D receptor-like receptors","P2A P-type ATPases: Ca<sup>2+</sup>-ATPases","CYP2 family: drug metabolising s
ubset","CYP3 family","SLCO family of organic anion transporting polypeptides","ABCB subfamily","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Muscle contraction","Neuronal System","Vesicle-mediated transport","Gene expression (Transcription)",Disease,"Metabolism of proteins",Hemostasis,"Immune System",Metabolism,"Cardiac conduction","Tran
smission across Chemical Synapses","Membrane Trafficking","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Post-translational prote
in modification",Translation,"Platelet homeostasis","Cytokine Signaling in Immune system","Biological oxidations","Metabolism of lipids","Abacavir transport and metabolism","Ion homeostasis","Neurotra
nsmitter receptors and postsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Generic Transcription Pathway","Signaling by TGF-beta Receptor Complex in Cancer",SUMOylation,"Eukaryoti
c Translation Initiation","Platelet calcium homeostasis","Signaling by Interleukins","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","Metabolism 
of steroids","Abacavir transmembrane transport","Signaling by FGFR in disease","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis","Transcriptional regulation 
by RUNX3","Loss of Function of TGFBR1 in Cancer","Transcriptional Regulation by TP53","SUMO E3 ligases SUMOylate target proteins","Transcriptional Regulation by MECP2","Cap-dependent Translation Initi
ation","Reduction of cytosolic Ca++ levels","Interleukin-12 family signaling","Cytochrome P450 - arranged by substrate type","Biosynthesis of DHA-derived SPMs","Bile acid and bile salt metabolism","Si
gnaling by FGFR3 in disease","Post NMDA receptor activation events","RUNX3 Regulates Immune Response and Cell Migration","TGFBR1 LBD Mutants in Cancer","Regulation of TP53 Activity","SUMOylation of in
tracellular receptors","MECP2 regulates neuronal receptors and channels","Activation of the mRNA upon binding of the cap-binding complex and eIFs","and subsequent binding to 43S","Interleukin-12 signa
ling",Xenobiotics,"Biosynthesis of maresins","Recycling of bile acids and salts","Signaling by FGFR3 point mutants in cancer","Activation of AMPK downstream of NMDARs","Regulation of TP53 Expression a
nd Degradation","Translation initiation complex formation","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","CYP2E1 reactions","Biosynthesis of maresin-like SPMs","
FGFR3 mutant receptor activation","Regulation of TP53 Degradation","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
{FKBP1A,MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{(RS)-rapamycin,(RS)rapamycin,"Rapamycin (Sirolimus)",28-epi-Rapamycin,28epiRapamycin,253431-35-5,253431355,SpecPlus_000840,SpecPlus000840,SpecPlus-000840,"SpecPlus 000840",DivK1c_006936,DivK1c006936,
DivK1c-006936,"DivK1c 006936","Rapamycin-d3 (Sirolimus-d3)","Rapamycind3 (Sirolimusd3)",CHEMBL3560003,KBio1_001880,KBio1001880,KBio1-001880,"KBio1 001880",HMS3265I15,HMS3265I16,HMS3265J15,HMS3265J16,3
92711-19-2,392711192,MCULE-7980881185,MCULE7980881185,Q27163,"EMD 553210",S1039,A-275,553210,Rapamycin(Sirolimus),Rapamycin}

> <pdid>
PD003274

> <targets>
{mTOR}

> <classes>
{}

> <pubchem_cids>
{5040}

$$$$
UTKinase_V5
  SciTegic11012413002D

 73 76  0  0  0  0            999 V2000
  -10.7377    1.1027    0.0000 C   0  0
   -9.7100    0.0100    0.0000 C   0  0
  -10.1800   -1.4400    0.0000 C   0  0
   -9.2500   -2.5000    0.0000 C   0  0
   -7.8600   -2.2400    0.0000 C   0  0
   -6.8600   -3.4400    0.0000 C   0  0
   -5.3700   -2.8300    0.0000 C   0  0
   -4.1200   -3.7800    0.0000 C   0  0
   -2.6300   -3.1700    0.0000 C   0  0
   -1.4100   -4.1500    0.0000 C   0  0
    0.1200   -3.6900    0.0000 C   0  0
    1.1200   -4.8600    0.0000 C   0  0
    2.7800   -4.7900    0.0000 C   0  0
    3.3400   -6.2300    0.0000 C   0  0
    4.8700   -6.7500    0.0000 C   0  0
    6.2500   -5.8600    0.0000 C   0  0
    6.5100   -4.2800    0.0000 C   0  0
    7.9504   -3.8613    0.0000 O   0  0
    5.5100   -3.1600    0.0000 C   0  0
    6.4400   -1.8000    0.0000 C   0  0
    5.8000   -0.4000    0.0000 C   0  0
    4.3600   -0.3900    0.0000 C   0  0
    3.4300    0.8000    0.0000 C   0  0
    2.0600    0.3500    0.0000 C   0  0
    1.8870   -1.1400    0.0000 O   0  0
    0.8000    1.1200    0.0000 C   0  0
    0.6400    2.7300    0.0000 C   0  0
   -0.7100    3.2100    0.0000 O   0  0
   -1.9000    2.2900    0.0000 C   0  0
   -1.8545    0.7907    0.0000 O   0  0
   -3.1200    3.1200    0.0000 C   0  0
   -2.6400    4.4900    0.0000 C   0  0
   -3.4600    5.5000    0.0000 C   0  0
   -4.8400    5.2900    0.0000 C   0  0
   -5.4800    3.8300    0.0000 C   0  0
   -4.5400    2.3900    0.0000 N   0  0
   -6.1000    2.2500    0.0000 C   0  0
   -7.0129    3.4402    0.0000 O   0  0
   -6.6100    0.8600    0.0000 C   0  0
   -5.5855   -0.2356    0.0000 O   0  0
   -8.0800    0.4300    0.0000 C   0  0
   -7.2300   -0.9300    0.0000 O   0  0
   -8.4778    1.8763    0.0000 O   0  0
    1.7909    3.6911    0.0000 C   0  0
    3.1995    3.1753    0.0000 C   0  0
    1.5337    5.1698    0.0000 C   0  0
    2.6850    6.1326    0.0000 C   0  0
    2.4301    7.6108    0.0000 C   0  0
    3.5827    8.5707    0.0000 C   0  0
    4.9903    8.0525    0.0000 C   0  0
    5.2453    6.5743    0.0000 C   0  0
    4.0927    5.6144    0.0000 C   0  0
    6.6527    6.0529    0.0000 O   0  0
    6.9056    4.5744    0.0000 C   0  0
    6.1416    9.0153    0.0000 O   0  0
    5.8843   10.4939    0.0000 C   0  0
    4.4758   11.0097    0.0000 O   0  0
    7.0356   11.4568    0.0000 C   0  0
    8.1867   12.4185    0.0000 C   0  0
    6.7783   12.9354    0.0000 C   0  0
    7.9290   13.8977    0.0000 O   0  0
    8.4448   10.9407    0.0000 C   0  0
    9.5964   11.9019    0.0000 O   0  0
    3.8662    2.2352    0.0000 C   0  0
    6.6151    0.8592    0.0000 C   0  0
    7.9345   -1.9281    0.0000 O   0  0
    4.0182   -3.2790    0.0000 O   0  0
    3.1659   -2.0447    0.0000 C   0  0
    7.5042   -6.6827    0.0000 C   0  0
    2.3025   -7.3134    0.0000 C   0  0
   -4.3154   -5.2672    0.0000 C   0  0
   -5.1674   -1.3437    0.0000 O   0  0
   -6.3526   -0.4242    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  3
 22 23  1  0
 23 24  1  0
 24 25  2  0
 24 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 29 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 31  1  0
 36 37  1  0
 37 38  2  0
 37 39  1  0
 39 40  2  0
 39 41  1  0
 41  2  1  0
 41 42  1  0
 42  5  1  0
 41 43  1  0
 27 44  1  0
 44 45  1  0
 44 46  1  0
 46 47  1  0
 47 48  1  0
 48 49  1  0
 49 50  1  0
 50 51  1  0
 51 52  1  0
 52 47  1  0
 51 53  1  0
 53 54  1  0
 50 55  1  0
 55 56  1  0
 56 57  2  0
 56 58  1  0
 58 59  1  0
 58 60  1  0
 60 61  1  0
 58 62  1  0
 62 63  1  0
 23 64  1  0
 21 65  1  0
 20 66  1  0
 19 67  1  0
 67 68  1  0
 16 69  1  0
 14 70  1  0
  8 71  1  0
  7 72  1  0
 72 73  1  0
M  END
> <name>
UTKinase_V5

> <id>
28518

> <plate>
Kinase v5-2

> <well>
G10

> <supplier_cmpd_name>
Temsirolimus

> <ctcr_id>
4859

> <supplier_cmpd_id>
S1044

> <smiles>
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC

> <pd_targets>
{MTOR,ABCC2,ABCC3,ABCC4,ABCB11,FKBP1A}

> <pathway_gtopdb>
{Enzyme,Transporter,Kinase,"Primary active transporter",Isomerase,"Protein Kinase","ATP-binding cassette","Atypical protein kinase group","ABCC subfamily","ABCB subfamily","Atypical protein kinase PIK
K family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Transporters,"Kinases (EC 2.7.x.x)","ATP-binding cassette transporter family","Peptidyl-prolyl cis/trans isomerases",Atypical,"ABCC subfamily","ABCB subfamily","Phosphatidyl inositol 3' kinas
e-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,Metabolism,Hemostasis,"RNA Polymerase II Transcription","Disorders of transmembrane transporters","Metabolism of lipids","Platelet activation","signaling and
 aggregation","Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","ABC transporter disorders","Metabolism of steroids","Response to eleva
ted platelet cytosolic Ca2+","Signaling by TGF-beta Receptor Complex in Cancer","Transcriptional Regulation by TP53","Defective ABCC2 causes DJS","Bile acid and bile salt metabolism","Platelet degranu
lation","Loss of Function of TGFBR1 in Cancer","Regulation of TP53 Activity","Recycling of bile acids and salts","Synthesis of bile acids and bile salts","TGFBR1 LBD Mutants in Cancer","Regulation of 
TP53 Expression and Degradation","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{Temsirolimus,162635-04-3,162635043,"162635 04 3",LSM-4295,LSM4295,"LSM 4295",FT-0674847,FT0674847,"FT 0674847",Q27165485,TEMSIROLIMUS}

> <pdid>
PD003551

> <targets>
{mTOR}

> <classes>
{}

> <pubchem_cids>
{148191}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 40  0  0  0  0            999 V2000
    7.7795   -7.5156    0.0000 C   0  0
    7.7840   -6.0157    0.0000 O   0  0
    6.4870   -5.2605    0.0000 C   0  0
    5.1855   -6.0062    0.0000 O   0  0
    6.4915   -3.7597    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1884   -2.6409    0.0000 C   0  0
   -4.6234   -3.0602    0.0000 C   0  0
   -4.9781   -4.5176    0.0000 C   0  0
   -3.8933   -5.5536    0.0000 N   0  0
   -2.4537   -5.1320    0.0000 C   0  0
   -2.0990   -3.6745    0.0000 C   0  0
   -4.2452   -7.0125    0.0000 C   0  0
   -5.6840   -7.4366    0.0000 O   0  0
   -3.1582   -8.0475    0.0000 O   0  0
   -3.5099   -9.5057    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 15  1  0
 14 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 25  1  0
 28 31  1  0
 31 32  2  0
 31 33  1  0
 33 34  1  0
 24 35  1  0
 35 21  1  0
 35 36  2  0
 36 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28519

> <plate>
Kinase v5-2

> <well>
G12

> <supplier_cmpd_name>
WYE-354

> <ctcr_id>
434

> <supplier_cmpd_id>
S1266

> <smiles>
COC(=O)Nc1ccc(cc1)c2nc(N3CCOCC3)c4cnn(C5CCN(CC5)C(=O)OC)c4n2

> <pd_targets>
{MTOR,MAPKAP1,MLST8,RICTOR,RPTOR,PIK3CA,PIK3CG}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Lipid modifying kinases","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","FRAP subfami
ly"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,Metabolism,"RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","Gener
ic Transcription Pathway","Signaling by FGFR in disease","Phospholipid metabolism","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","PI Metabolism","Regulation of TP53 Activity","F
GFR1 mutant receptor activation","Synthesis of PIPs at the plasma membrane","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradatio
n"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{WYE-354,WYE354,1062169-56-5,1062169565,"WYE 354","pyrazolo pyrimidine, 19",cc-506,cc506,MLS006011008,SCHEMBL300431,CHEMBL561708,GTPL9361,BDBM35587,CHEBI:94742,DTXSID00657912,C24H29N7O5,HMS3654N09,BCP
02898,ZINC43013490,CCG-264882,CCG264882,CS-0183,CS0183,SB19260,NCGC00242484-01,NCGC0024248401,NCGC0,T6731,S1266}

> <pdid>
PD011035

> <targets>
{mTOR,Apoptosis,Autophagy}

> <classes>
{PI3K/Akt/mTOR,Apoptosis,Autophagy}

> <pubchem_cids>
{44219749}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
  -14.8054    1.5994    0.0000 C   0  0
  -14.3471    0.1711    0.0000 N   0  0
  -15.3549   -0.9399    0.0000 C   0  0
  -14.8966   -2.3682    0.0000 C   0  0
  -13.4306   -2.6856    0.0000 N   0  0
  -12.9691   -4.1137    0.0000 C   0  0
  -11.5018   -4.4291    0.0000 C   0  0
  -10.4979   -3.3146    0.0000 C   0  0
   -9.0307   -3.6268    0.0000 C   0  0
   -8.5674   -5.0535    0.0000 C   0  0
   -7.1001   -5.3688    0.0000 N   0  0
   -6.6386   -6.7970    0.0000 C   0  0
   -7.6445   -7.9097    0.0000 O   0  0
   -5.1713   -7.1123    0.0000 C   0  0
   -4.7081   -8.5390    0.0000 C   0  0
   -3.2409   -8.8512    0.0000 C   0  0
   -2.2370   -7.7366    0.0000 C   0  0
   -0.7698   -8.0488    0.0000 C   0  0
   -2.7002   -6.3100    0.0000 C   0  0
   -4.1674   -5.9978    0.0000 C   0  0
   -1.6958   -5.1948    0.0000 C   0  0
   -0.6913   -4.0797    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -9.5715   -6.1680    0.0000 C   0  0
  -11.0386   -5.8558    0.0000 C   0  0
  -12.0431   -6.9709    0.0000 C   0  0
  -11.5808   -8.3979    0.0000 F   0  0
  -13.5102   -6.6582    0.0000 F   0  0
  -13.0476   -8.0849    0.0000 F   0  0
  -12.4228   -1.5745    0.0000 C   0  0
  -12.8811   -0.1462    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 14  1  0
 19 21  1  0
 21 22  3  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 23  1  0
 31 26  1  0
 10 32  1  0
 32 33  2  0
 33  7  1  0
 33 34  1  0
 34 35  1  0
 34 36  1  0
 34 37  1  0
  5 38  1  0
 38 39  1  0
 39  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28520

> <plate>
Kinase v5-2

> <well>
G14

> <supplier_cmpd_name>
AP24534

> <ctcr_id>
2107

> <supplier_cmpd_id>
S1490

> <smiles>
CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc4cnc5cccnn45)cc2C(F)(F)F)CC1

> <pd_targets>
{FGFR3,FGFR4,FGFR2,PDGFRA,ABL1,KIT,SRC,BCR,FGFR1,RIPK2,KDR,RET,FLT1,ABL2,LYN,PDGFRB,CDK8,CDK19,RIPK1,GSK3B,RIPK3,CCDC6,FLT3,TEK,LCK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Atypical protein kinase group","TKL protein kinase group","CMGC protein kinase group","Tyrosine protein kinase FGFR family","Tyrosine protein
 kinase PDGFR family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Src family","Atypical protein kinase BCR family","TKL protein kinase RIPK family","Tyrosine protein kinase VEGFR fam
ily","Tyrosine protein kinase Ret family","CMGC protein kinase CDK family","CMGC protein kinase GSK family","Tyrosine protein kinase Tie family","CMGC protein kinase CDK8 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Cyclin-de
pendent kinase (CDK) family","Glycogen synthase kinase (GSK) family","BCR family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Receptor interacting protein kinase (RIPK)
 family","CDK8 subfamily","GSK subfamily","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Abl family","Src family","Type IV RTKs: 
VEGF (vascular endothelial growth factor) receptor family","Type XIV RTKs: RET","Type XII RTKs: TIE family of angiopoietin receptors"}

> <pathway_reactome>
{Disease,"Signal Transduction","Immune System","Developmental Biology",Metabolism,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kin
ases","Infectious disease","Innate Immune System","Nervous system development","Intracellular signaling by second messengers","Metabolism of lipids","MAPK family signaling cascades","Signaling by FGFR
 in disease","Signaling by FGFR","Signaling by PDGFR in disease","Leishmania infection","Signaling by KIT in disease","Signaling by NTRKs","Toll-like Receptor Cascades","Signaling by VEGF","Axon guida
nce","PIP3 activates AKT signaling","Signaling by NOTCH1 in Cancer","Regulation of lipid metabolism by PPARalpha","SARS-CoV Infections","Signaling by Insulin receptor","MAPK1/MAPK3 signaling","HIV Inf
ection","Signaling by FGFR3 in disease","Signaling by FGFR4","Signaling by FGFR2 in disease","Drug resistance of PDGFR mutants","Parasite infection","Drug resistance of KIT mutants","Signaling by NTRK
1 (TRKA)","Signaling by FGFR1 in disease","Toll Like Receptor 5 (TLR5) Cascade","VEGFA-VEGFR2 Pathway","RET signaling","VEGF ligand-receptor interactions","Leishmania parasite growth and survival","Ne
gative regulation of the PI3K/AKT network","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","PPARA activates gene expression","Toll Like Receptor 4 (TLR4) Cascade","SARS-CoV-1 Infection","Insuli
n receptor signalling cascade","RAF/MAP kinase cascade","Host Interactions of HIV factors","Signaling by FGFR3 point mutants in cancer","Downstream signaling of activated FGFR4","FGFR2 mutant receptor
 activation","Imatinib-resistant PDGFR mutants","Leishmania phagocytosis","Dasatinib-resistant KIT mutants","Signalling to ERKs","FGFR1 mutant receptor activation","MyD88 cascade initiated on plasma m
embrane","VEGFR2 mediated cell proliferation","VEGF binds to VEGFR leading to receptor dimerization","Anti-inflammatory response favouring Leishmania parasite infection",PI5P,"PP2A and IER3 Regulate P
I3K/AKT Signaling","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","MyD88-independent TLR4 cascade","SARS-CoV-1 Genome Replication and Transcription","IRS-mediated signalling","The role of N
ef in HIV-1 replication and disease pathogenesis","FGFR3 mutant receptor activation","FRS-mediated FGFR4 signaling","Activated point mutants of FGFR2","FCGR3A-mediated phagocytosis","Signalling to RAS
","Signaling by activated point mutants of FGFR1","MAP kinase activation","FCGR3A-mediated IL10 synthesis","TRIF(TICAM1)-mediated TLR4 signaling","Replication of the SARS-CoV-1 genome","PI3K Cascade",
"Signaling by cytosolic FGFR1 fusion mutants","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Signaling by activated point mutants of FGFR3","p38MAPK 
events","activated TAK1 mediates p38 MAPK activation","IKK complex recruitment mediated by RIP1","Nef Mediated CD4 Down-regulation"}

> <broad_targets>
{ABL1,BCR,FGFR1,FGFR2,FGFR3,FGFR4,FLT3,KDR,KIT,LCK,LYN,PDGFRA,RET,SRC,TEK}

> <broad_moa>
{"Bcr-Abl kinase inhibitor","FLT3 inhibitor","PDGFR tyrosine kinase receptor inhibitor"}

> <synonyms>
{D09950,Q-4579,Q4579,AB01565847_03,AB0156584703,AB01565847-03,"AB01565847 03",Q198728,PONATINIB,943319-70-8,943319708,AP24534,"Ponatinib (AP24534)","AP 24534",Iclusig,AP-24534,UNII-4340891KFS,UNII4340
891KFS,AP24534(Ponatinib),CHEMBL1171837,CHEBI:78543,"943319-70-8 (free base)","943319708 (free base)",4340891KFS,C29H27F3N6O,"Ponatinib (USAN:INN)",T2372,758487,Ponatinib,S1490}

> <pdid>
PD004100

> <targets>
{"FGFR | FLT-3 | Src-bcr-Abl | VEGFR-",Flt,FGFR,VEGFR,Bcr-Abl,PDGFR,Autophagy,Src}

> <classes>
{Bcr-Abl inhibitor,Angiogenesis,Autophagy,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{24826799}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 29  0  0  0  0            999 V2000
    9.5296    5.3036    0.0000 C   0  0
    8.5280    6.4202    0.0000 C   0  0
    7.0602    6.1110    0.0000 C   0  0
    6.0585    7.2276    0.0000 C   0  0
    6.5247    8.6533    0.0000 C   0  0
    7.9925    8.9625    0.0000 C   0  0
    8.9942    7.8459    0.0000 C   0  0
    5.5249    9.7726    0.0000 N   0  3
    5.9931   11.1977    0.0000 O   0  0
    4.0565    9.4660    0.0000 O   0  5
    6.5937    4.6845    0.0000 S   0  0
    7.5957    3.5683    0.0000 O   0  0
    6.1282    3.2586    0.0000 O   0  0
    5.1253    4.3743    0.0000 N   0  0
    4.1233    5.4906    0.0000 C   0  0
    4.6588    2.9478    0.0000 N   0  0
    3.1904    2.6376    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Br  0  0
   12.0301    4.8492    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  3
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  1  0
  3 11  1  0
 11 12  2  0
 11 13  2  0
 11 14  1  0
 14 15  1  0
 14 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  2  3
 21 22  1  0
 22 18  1  0
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  3
 26 21  1  0
 24 27  1  0
M  CHG  2   8   1  10  -1
M  END
> <name>
UTKinase_V5

> <id>
28521

> <plate>
Kinase v5-2

> <well>
G16

> <supplier_cmpd_name>
PIK-75 Hydrochloride

> <ctcr_id>
4117

> <supplier_cmpd_id>
S1205

> <smiles>
CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)N=CC2=CN=C3N2C=C(C=C3)Br.Cl

> <pd_targets>
{PIK3CA,PIK3CD,CDK7,CDK9,PIK3CB,PIK3C2B,FLT3,CDK2,PIK3CG,GSK3B,PRKDC,CCNT1}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","CMGC protein kinase group","TK protein kinase group","Atypical protein kinase group","CMGC protein kinase CDK family","Tyrosine protein kinase PDGFR family
","CMGC protein kinase GSK family","Atypical protein kinase PIKK family","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases",Atypical,Phosphatidylinositol-4,"5-bisphosp
hate 3-kinase family","Cyclin-dependent kinase (CDK) family","Phosphatidylinositol-4-phosphate 3-kinase family","TK: Tyrosine kinase","Glycogen synthase kinase (GSK) family","Phosphatidyl inositol 3' 
kinase-related kinases (PIKK) family","CDK7 subfamily","CDK9 subfamily","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","GSK subfamily","Other PIKK family kinases","Type III RTKs: PDGFR",CSFR,Kit,
"FLT3 receptor family"}

> <pathway_reactome>
{Disease,"Immune System","Signal Transduction",Metabolism,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Im
mune system","Infectious disease","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","RNA Polymerase II Transcription","Innate Immune System","Signaling by FGFR in disease","Signaling by 
Interleukins","HIV Infection","Signaling by Insulin receptor","Phospholipid metabolism","Generic Transcription Pathway","SARS-CoV Infections","Cytosolic sensors of pathogen-associated DNA","Signaling 
by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","HIV Life Cycle","Insulin receptor signalling cascade","PI Metabolism","Transcriptional Regulation by TP53","SARS-CoV-1 Infectio
n","STING mediated induction of host immune responses","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","Late Phase of HIV Life Cycle","IRS-mediated signalling","Synthesis of PI
Ps at the plasma membrane","Regulation of TP53 Activity","SARS-CoV-1 Genome Replication and Transcription","IRF3-mediated induction of type I IFN","Signaling by cytosolic FGFR1 fusion mutants","Transc
ription of the HIV genome","PI3K Cascade","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-1 genome","HIV Transcription Elongation","Regulation of TP53 Degradation","Tat-me
diated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC}

> <broad_moa>
{"DNA protein kinase inhibitor","PI3K inhibitor"}

> <synonyms>
{IK7,372196-77-5,372196775,"PIK 75 hydrochloride",PIK-75,PIK75,AKOS026750407,AK547777,DB-058066,DB058066,FT-0773028,FT0773028,S1205,"PIK-75 Hydrochloride"}

> <pdid>
PD016738

> <targets>
{PIK75,DNA-PK,PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{75106606}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    4.8089   -4.6669    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4990    0.7409    0.0000 N   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0994    0.7387    0.0000 C   0  0
  -10.3984    1.4886    0.0000 C   0  0
  -10.3985    2.9886    0.0000 C   0  0
   -9.0995    3.7387    0.0000 C   0  0
   -7.8004    2.9887    0.0000 N   0  0
  -11.6983    3.7390    0.0000 C   0  0
  -12.9973    4.4890    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    0.0071   -7.5009    0.0000 Cl  0  0
   -1.2955   -5.2529    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -2.5981   -3.0050    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 18 21  1  0
 21 22  3  0
 10 23  1  0
 23 24  2  0
 24  7  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 28 30  1  0
 30 31  2  0
 31 25  1  0
 31 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28522

> <plate>
Kinase v5-2

> <well>
G18

> <supplier_cmpd_name>
CHIR-99021

> <ctcr_id>
1214

> <supplier_cmpd_id>
S1263

> <smiles>
Cc1c[nH]c(n1)c2cnc(NCCNc3ccc(cn3)C#N)nc2c4ccc(Cl)cc4Cl

> <pd_targets>
{CCNB1,CCNB2,CCNB3,CDK1,GSK3B,CSNK1G1,GSK3A,MAPK1,RPS6KB1,LIMK1,CDK2,SLK,CLK4,TAOK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CK1 protein kinase group","AGC protein kinase group","TKL protein kinase group","STE protein kinase group","CMGC protein kinase CDK family"
,"CMGC protein kinase GSK family","CK1 protein kinase CK1 family","CMGC protein kinase MAPK family","AGC protein kinase RSK family","TKL protein kinase LISK family","STE protein kinase STE20 family","
CMGC protein kinase CLK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase ERK1","AGC protein kinase p70 subfamily","TKL protein kinase LIMK subfamily","STE protein kinase SLK subfamily
","STE protein kinase TAO subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","Receptor kinases","STE:
 Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Glycogen synthase kinase (GSK) family","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","Cyclin-depende
nt kinase (CDK) family","RSK family","TKL: Tyrosine kinase-like","STE20 family","CLK family","GSK subfamily","ERK subfamily","CDK1 subfamily","p70 subfamily","LIM domain kinase (LISK) family","SLK sub
family","TAO subfamily","LIMK subfamily"}

> <pathway_reactome>
{Disease,"Immune System","Cell Cycle","Signal Transduction","Developmental Biology","Gene expression (Transcription)","Infectious disease","Innate Immune System",Mitotic,"MTOR signalling","Nervous sys
tem development","RNA Polymerase II Transcription","SARS-CoV Infections","Toll-like Receptor Cascades","Regulation of mitotic cell cycle","mTORC1-mediated signalling","Axon guidance","Generic Transcri
ption Pathway","M Phase","SARS-CoV-1 Infection","Toll Like Receptor 5 (TLR5) Cascade","APC/C-mediated degradation of cell cycle proteins","Semaphorin interactions","Transcriptional Regulation by TP53"
,"Mitotic Metaphase and Anaphase","SARS-CoV-1 Genome Replication and Transcription","MyD88 cascade initiated on plasma membrane","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic pr
oteins","Sema4D in semaphorin signaling","Regulation of TP53 Activity","Mitotic Anaphase","Replication of the SARS-CoV-1 genome","MAP kinase activation","APC/C:Cdc20 mediated degradation of mitotic pr
oteins","Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Expression and Degradation","Separation of Sister Chromatids","MAPK targets/ Nuclear events mediated by MAP kinases
","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Regulation of TP53 Degradation","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradatio
n of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CDK1,GSK3A,GSK3B,MAPK1}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{HIR9902,"HIR 9902",CHIR-99021,CHIR99021,"CHIR 99021",252917-06-9,252917069,"252917 06 9",CT99021,"CT 99021",CT-99021,"GSK-3 Inhibitor XVI","GSK3 Inhibitor XVI","GSK 3 Inhibitor XVI",UNII-234CMT4GK4,U
NII234CMT4GK4,"UNII 234CMT4GK4",CHIR-911,CHIR911,CHIR,S1263}

> <pdid>
PD003256

> <targets>
{GSK-3,GSK3}

> <classes>
{}

> <pubchem_cids>
{9956119}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 23  0  0  0  0            999 V2000
    2.5532   -4.4223    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -0.2491   -5.5022    0.0000 N   0  0
   -1.4850   -6.3508    0.0000 C   0  0
   -1.6812   -7.8379    0.0000 C   0  0
   -3.0671   -8.4116    0.0000 C   0  0
   -4.2569   -7.4981    0.0000 C   0  0
   -4.0607   -6.0110    0.0000 C   0  0
   -2.6748   -5.4373    0.0000 C   0  0
   -2.1742   -4.0242    0.0000 C   0  0
   -3.0159   -2.7826    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10  2  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 11  1  0
 19 20  2  0
M  END
> <name>
UTKinase_V5

> <id>
28523

> <plate>
Kinase v5-2

> <well>
G20

> <supplier_cmpd_name>
Indirubin

> <ctcr_id>
7712

> <supplier_cmpd_id>
S2386

> <smiles>
O=C/1Nc2ccccc2C1=C/3Nc4ccccc4C3=O

> <pd_targets>
{SRC,SMN1,CCNA2,CDK2,CDC42,RAC1,GSK3B,CDK5,CDK5R1,GSK3A,PYK,MAPT,RAB9A,MAPK1,CDK1,CCND1,CDK4,RAB7A,CTRB1,RAB2A,CCNE1,KMT2A,MEN1,CCNB1,CCNB2,CCNB3,CDK10,CDK11B,CDK12,CDK13,CDK14,CDK15,CDK16,CDK17,CDK18
,CDK19,CDK20,CDK3,CDK6,CDK7,CDK8,CDK9,CYP1A1,AHR}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Transcription factor",Kinase,Reader,Hydrolase,Transferase,Protease,"Cytochrome P450","Protein Kinase","Methyl-lysine/arginine binding protein"
,"Serine protease",Bromodomain,"Cytochrome P450 family 1","TK protein kinase group","Tudor domain","CMGC protein kinase group","Serine protease PA clan","Cytochrome P450 family 1A","Tyrosine protein k
inase Src family","CMGC protein kinase CDK family","CMGC protein kinase GSK family","CMGC protein kinase MAPK family","Serine protease S1A subfamily","Cytochrome P450 1A1","CMGC protein kinase CDC2 su
bfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","Aryl hydrocarbon receptor","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families"
,"CYP1 family","TK: Tyrosine kinase","Glycogen synthase kinase (GSK) family","Mitogen-activated protein kinases (MAP kinases)","Cyclin-dependent kinase (CDK) family","Non-receptor tyrosine kinases (nR
TKs)","GSK subfamily","ERK subfamily","CDK1 subfamily","Src family"}

> <pathway_reactome>
{"Signal Transduction","Metabolism of RNA",Disease,"Developmental Biology","Neuronal System","Immune System","Cell Cycle","Gene expression (Transcription)",Metabolism,"Signaling by Receptor Tyrosine K
inases","Metabolism of non-coding RNA","Infectious disease","Nervous system development","Transmission across Chemical Synapses","Signaling by Rho GTPases","Innate Immune System",Mitotic,"RNA Polymera
se II Transcription","Metabolism of vitamins and cofactors","Biological oxidations","Signaling by NTRKs","snRNP Assembly","Leishmania infection","Axon guidance","SARS-CoV Infections","Neurotransmitter
 receptors and postsynaptic signal transmission","Rho GTPase cycle","Toll-like Receptor Cascades","Regulation of mitotic cell cycle","Infection with Mycobacterium tuberculosis","Generic Transcription 
Pathway","Metabolism of water-soluble vitamins and cofactors","M Phase","Phase I - Functionalization of compounds","Signaling by NTRK1 (TRKA)","Parasite infection","Semaphorin interactions","SARS-CoV-
1 Infection","Activation of NMDA receptors and postsynaptic events","RHOBTB GTPase Cycle","Toll Like Receptor 5 (TLR5) Cascade","APC/C-mediated degradation of cell cycle proteins","Response of Mtb to 
phagocytosis","Transcriptional Regulation by TP53","Cobalamin (Cbl","vitamin B12) transport and metabolism","Mitotic Prophase","Cytochrome P450 - arranged by substrate type","Signalling to ERKs","Leis
hmania phagocytosis","Sema4D in semaphorin signaling","SARS-CoV-1 Genome Replication and Transcription","Post NMDA receptor activation events","RHOBTB3 ATPase cycle","MyD88 cascade initiated on plasma
 membrane","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Suppression of phagosomal maturation","Regulation of TP53 Activity","Golgi Cisternae Pericentriolar Stack Reo
rganization",Xenobiotics,"Endogenous sterols","Signalling to RAS","FCGR3A-mediated phagocytosis","Sema4D mediated inhibition of cell attachment and migration","Replication of the SARS-CoV-1 genome","A
ctivation of AMPK downstream of NMDARs","MAP kinase activation","APC/C:Cdc20 mediated degradation of mitotic proteins","Prevention of phagosomal-lysosomal fusion","Regulation of TP53 Expression and De
gradation","p38MAPK events","MAPK targets/ Nuclear events mediated by MAP kinases","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Regulation
 of TP53 Degradation","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CDK1,CDK5,GSK3A}

> <broad_moa>
{"CDK inhibitor","glycogen synthase kinase inhibitor"}

> <synonyms>
{Indirubin,CC-206}

> <pdid>
PD010731

> <targets>
{GSK-3,Apoptosis}

> <classes>
{Apoptosis}

> <pubchem_cids>
{5318433}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.3342   -4.5421    0.0000 C   0  0
    6.4049   -6.0405    0.0000 C   0  0
    5.1427   -6.8509    0.0000 C   0  0
    5.2134   -8.3492    0.0000 Cl  0  0
    3.8097   -6.1630    0.0000 C   0  0
    3.7390   -4.6647    0.0000 C   0  0
    2.4063   -3.9763    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10  5  1  0
  4 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 12 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 18  1  0
 24 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28524

> <plate>
Kinase v5-2

> <well>
G22

> <supplier_cmpd_name>
SB 216763

> <ctcr_id>
5668

> <supplier_cmpd_id>
S1075

> <smiles>
Cn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4ccc(Cl)cc4Cl

> <pd_targets>
{CCNA1,CCNA2,CDK2,MAPK1,CCNB1,CCNB2,CCNB3,CDK1,NFO,THPO,USP2,GMNN,GSK3B,MAPT,CYP2C19,MEX-5,ALD,HTT,HBB,GSK3A,KMT2A,MEN1,NFKB1,APEX1,HIF1A,CYP3A4,CYP2C9,LMNA,RORC,POLB,CCND1,CDK4,RECQL,FTL,CYP1A2,LEF,C
YP2D6,POS-1,PAX8}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Other cytosolic protein","Transcription factor","Secreted protein","Epigenetic regulator","Other nuclear protein",Kinase,Hydrolase,Protease,"Cytochrome P450",Reader,"Nu
clear receptor","Protein Kinase","Cysteine protease","Cytochrome P450 family 2",Bromodomain,"Cytochrome P450 family 3","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 1","Metallo protea
se","CMGC protein kinase group","Cysteine protease CA clan","Cytochrome P450 family 2C","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 1A","Metallo 
protease MAE clan","Cytochrome P450 family 2D","CMGC protein kinase CDK family","CMGC protein kinase MAPK family","Cysteine protease C19 family","CMGC protein kinase GSK family","Cytochrome P450 2C19"
,"Cytochrome P450 3A4","Cytochrome P450 2C9","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 1A1","Metallo protease M34 family","Cytochrome P450 2D6","CMGC protein kinase CDC2
 subfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Peptidases and proteinases","Cytochrome P450","Chromatin modifying enzymes","Nuclear hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CA: 
Cysteine (C) Peptidases","CYP2 family: drug metabolising subset","CYP3 family","2.1.1.43 Histone methyltransferases (HMTs)","1F. Retinoic acid-related orphans","CYP1 family","Mitogen-activated protein
 kinases (MAP kinases)","C19: Ubiquitin-specific protease","Glycogen synthase kinase (GSK) family","ERK subfamily","GSK subfamily"}

> <pathway_reactome>
{"Immune System",Hemostasis,"Gene expression (Transcription)","Cell Cycle",Disease,"Neuronal System",Metabolism,"DNA Repair","Cellular responses to external stimuli","Vesicle-mediated transport","Inna
te Immune System","Platelet activation","signaling and aggregation","RNA Polymerase II Transcription",Mitotic,"Infectious disease","Transmission across Chemical Synapses","Biological oxidations","Cyto
kine Signaling in Immune system","Base Excision Repair","Cellular responses to stress","Metabolism of lipids","Membrane Trafficking","Toll-like Receptor Cascades","Platelet Aggregation (Plug Formation
)","Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","SARS-CoV Infections","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization of compou
nds","Neutrophil degranulation","Signaling by Interleukins","Resolution of Abasic Sites (AP sites)","Cellular response to hypoxia","Biosynthesis of specialized proresolving mediators (SPMs)","M Phase"
,"trans-Golgi Network Vesicle Budding","Uptake and actions of bacterial toxins","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional Regulation by TP53","G1/S Transition","SARS-CoV-1 Infection","Act
ivation of NMDA receptors and postsynaptic events","Cytochrome P450 - arranged by substrate type","Transcriptional Regulation by MECP2","Interleukin-1 family signaling","Resolution of AP sites via the
 multiple-nucleotide patch replacement pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Biosynthesis of DHA-derived SPMs","Mitotic Metaphase and Anaphase","Transcri
ptional regulation by RUNX1","Transcriptional regulation by RUNX3","Golgi Associated Vesicle Biogenesis","Uptake and function of anthrax toxins","MyD88 cascade initiated on plasma membrane","Regulatio
n of TP53 Activity","Activation of the pre-replicative complex","SARS-CoV-1 Genome Replication and Transcription","Post NMDA receptor activation events",Xenobiotics,"Regulation of MECP2 expression and
 activity","Interleukin-1 signaling","PCNA-Dependent Long Patch Base Excision Repair","Biosynthesis of maresins","Mitotic Anaphase","RUNX1 regulates genes involved in megakaryocyte differentiation and
 platelet function","RUNX3 Regulates Immune Response and Cell Migration","MAP kinase activation","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-1 genome","Activation of A
MPK downstream of NMDARs","CYP2E1 reactions","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of maresin-like SPMs","Nuclear Envelope (NE) Reassembly","Aromatic amines can be N-hydroxylated 
or N-dealkylated by CYP1A2","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Initiation of Nuclear Envelope (NE) Reformation","ERK/MAPK targets","ERKs are inact
ivated"}

> <broad_targets>
{CCNA2,CDK2,GSK3A,GSK3B}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{280744-09-4,280744094,"SB 216763","3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione","3(2,4Dichlorophenyl)4(1methyl1Hindol3yl)1Hpyrrole2,5dione",SB216763,SB-216763,"3-(2,4-dichl
orophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione","3(2,4dichlorophenyl)4(1methylindol3yl)pyrrole2,5dione",C19H12Cl2N2O2,1H-Pyrrole-2,1HPyrrole2,5-dione,5dione,3-(2,3(2,4-dichlorophenyl)-4-,4dichloro
phenyl)4,T3077,1616,S1075}

> <pdid>
PD002648

> <targets>
{GSK-3,GSK3}

> <classes>
{}

> <pubchem_cids>
{176158}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 44  0  0  1  0            999 V2000
    6.4789   -8.2669    0.0000 C   0  0
    5.1824   -7.5124    0.0000 C   0  0  2  0  0  0
    5.1876   -6.0124    0.0000 C   0  0
    3.8912   -5.2578    0.0000 N   0  0
    2.5895   -6.0034    0.0000 C   0  0
    2.5844   -7.5034    0.0000 C   0  0  2  0  0  0
    1.2827   -8.2489    0.0000 C   0  0
    3.8808   -8.2579    0.0000 O   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 S   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -5.1962    3.0007    0.0000 C   0  0
   -6.4940    3.7529    0.0000 C   0  0
   -6.4917    5.2529    0.0000 C   0  0
   -7.7895    6.0049    0.0000 O   0  0
   -5.1914    6.0008    0.0000 C   0  0
   -3.8936    5.2488    0.0000 C   0  0
   -3.8960    3.7488    0.0000 O   0  0
   -2.5927    5.9971    0.0000 N   0  0
   -2.5879    7.4972    0.0000 C   0  0
   -1.2865    8.2430    0.0000 C   0  0
    0.0102    7.4889    0.0000 O   0  0
    0.0054    5.9889    0.0000 C   0  0
   -1.2960    5.2431    0.0000 C   0  0
  2  1  1  1
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  1
  6  8  1  0
  8  2  1  0
  4  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
 21 22  2  0
 22 13  1  0
 19 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 18  1  0
 26 27  1  0
 27 28  2  3
 28 29  1  0
 29 30  2  0
 29 31  1  0
 31 32  2  3
 32 33  1  0
 33 27  1  0
 32 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 39  1  0
 39 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28525

> <plate>
Kinase v5-2

> <well>
I04

> <supplier_cmpd_name>
KU-60019

> <ctcr_id>
7152

> <supplier_cmpd_id>
S1570

> <smiles>
C[C@@H]1CN(C[C@H](C)O1)CC(=O)Nc2ccc3Sc4c(Cc3c2)cccc4C5=CC(=O)C=C(O5)N6CCOCC6

> <pd_targets>
{ATM}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Other PIKK family kinases"}

> <pathway_reactome>
{"Cell Cycle","Cell Cycle Checkpoints","G1/S DNA Damage Checkpoints","p53-Dependent G1/S DNA damage checkpoint","p53-Dependent G1 DNA Damage Response","Stabilization of p53","Autodegradation of the E3
 ubiquitin ligase COP1"}

> <broad_targets>
{ATM}

> <broad_moa>
{"ATM kinase inhibitor"}

> <synonyms>
{KU-60019,KU60019,925701-49-1,925701491,ku60019,"KU 60019",UNII-IAN358A69K,UNIIIAN358A69K,925701-46-8,925701468,IAN358A69K,CHEMBL2140173,C30H33N3O5S,cc-509,cc509,MLS006011020,GTPL8041,SCHEMBL3681453,A
OB3627,DTXSID00580453,EX-A658,EXA658,BCP02304,ABP000418,BDBM50059640,s1570,AKOS024458015,ZINC100071759,CCG,S1570}

> <pdid>
PD003277

> <targets>
{ATM}

> <classes>
{}

> <pubchem_cids>
{15953870}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
   13.2524   -0.5550    0.0000 Cl  0  0
   10.7524   -0.5550    0.0000 Cl  0  0
    6.4878   -5.2574    0.0000 N   0  0
    6.4934   -3.7574    0.0000 C   0  0
    6.8046   -2.3560    0.0000 C   0  0
    8.2524   -2.7481    0.0000 C   0  0
    7.8603   -4.1959    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -4.0238    3.4635    0.0000 C   0  0
   -4.4873    4.8901    0.0000 O   0  0
   -4.9055    2.2500    0.0000 N   0  0
   -4.0238    1.0365    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  4  1  0
  4  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  2  3
 24 19  1  0
 24 25  1  0
 25 16  2  0
 25 26  1  0
 26 27  2  0
 27 14  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28526

> <plate>
Kinase v5-2

> <well>
I06

> <supplier_cmpd_name>
MK-2206

> <ctcr_id>
1270

> <supplier_cmpd_id>
S1078

> <smiles>
Cl.Cl.NC1(CCC1)c2ccc(cc2)c3nc4C=CN5C(=O)NN=C5c4cc3c6ccccc6

> <pd_targets>
{AKT1,AKT3,AKT2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase AKT family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Akt (Protein kinase B","PKB) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Generic Transcription Pathway","Signaling by Insulin receptor","Tra
nscriptional Regulation by TP53","Insulin receptor signalling cascade","Regulation of TP53 Activity","IRS-mediated signalling","Regulation of TP53 Expression and Degradation","PI3K Cascade","Regulatio
n of TP53 Degradation","PKB-mediated events","PDE3B signalling"}

> <broad_targets>
{AKT1,AKT2,AKT3}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{K220,1032350-13-2,1032350132,"MK-2206 dihydrochloride","MK2206 dihydrochloride","MK-2206 2HCl","MK2206 2HCl",MK2206,"MK-2206 HCl salt","MK2206 HCl salt",UNII-Q34I3E28IO,UNIIQ34I3E28IO,"MK 2206",Q34I3
E28IO,C25H21N5O,"MK 2206 2HCl","AHU377 calcium salt",PubChem22473,1032349-77-1,1032349771,"MK 2206 dihydrochloride",C25H21N5O.HCl,cc-295,cc295,C25H21N5O.,T1952,S1078,"MK-2206 2HCl",MK-2206,"MK-2206 (d
ihydrochloride)"}

> <pdid>
PD003288

> <targets>
{Akt,AKT,Apoptosis,Autophagy}

> <classes>
{Apoptosis,Autophagy,PI3K/Akt/mTOR}

> <pubchem_cids>
{46930998}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
   -7.6380   -7.9104    0.0000 C   0  0
   -6.1715   -8.2255    0.0000 N   0  0
   -5.7116   -9.6532    0.0000 C   0  0
   -5.1640   -7.1130    0.0000 C   0  0
   -3.6967   -7.4283    0.0000 C   0  0
   -3.2334   -8.8550    0.0000 C   0  0
   -1.7662   -9.1671    0.0000 C   0  0
   -0.7624   -8.0525    0.0000 C   0  0
   -1.2256   -6.6258    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 N   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
    1.2946    3.7531    0.0000 O   0  0
   -1.3039    3.7494    0.0000 N   0  0
   -1.3070    5.2494    0.0000 C   0  0
   -2.6017    2.9971    0.0000 C   0  0
   -2.1574   -3.7721    0.0000 C   0  0
   -2.6252   -2.3468    0.0000 C   0  0
   -4.0934   -2.0392    0.0000 C   0  0
   -5.0938   -3.1569    0.0000 C   0  0
   -4.6261   -4.5821    0.0000 C   0  0
   -3.1580   -4.8897    0.0000 C   0  0
   -2.6928   -6.3138    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 12  1  0
 21 16  1  0
 18 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 24 26  1  0
 11 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
  9 33  2  0
 33  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28527

> <plate>
Kinase v5-2

> <well>
I08

> <supplier_cmpd_name>
BIX 02189

> <ctcr_id>
7137

> <supplier_cmpd_id>
S1531

> <smiles>
CN(C)Cc1cccc(N\C(=C\2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)\c4ccccc4)c1

> <pd_targets>
{MAP2K5,MAPK7,TGFBR1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","CMGC protein kinase group","TKL protein kinase group","STE protein kinase STE7 family","CMGC protein kinase MAPK family","TKL protein kinase
 STKR family","CMGC protein kinase ERK5","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases",
"STE7 family","Mitogen-activated protein kinases (MAP kinases)","TKL: Tyrosine kinase-like","ERK subfamily","Receptor serine/threonine kinase (RSTK) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Disease,"Signaling by Receptor Tyrosine Kinases","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Signa
ling by NTRKs","Toll-like Receptor Cascades","Signaling by TGF-beta Receptor Complex in Cancer","Signaling by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) Cascade","Loss of Function of SMAD2/3 in Cancer
","Signalling to ERK5","MyD88 cascade initiated on plasma membrane","SMAD2/3 Phosphorylation Motif Mutants in Cancer","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","ER
K/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{MAP2K5,MAPK7}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{S1531,"BIX 02189"}

> <pdid>
PD010988

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{46931012}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5989    1.5003    0.0000 C   0  0
   -3.8987    2.2073    0.0000 C   0  0
   -3.9004    3.7073    0.0000 C   0  0
   -2.6022    4.4587    0.0000 N   0  0
   -1.3023    3.7102    0.0000 C   0  0
   -1.3006    2.2102    0.0000 C   0  0
   -3.8974    0.7469    0.0000 C   0  0
   -3.8943   -0.7531    0.0000 C   0  0
   -5.1918   -1.5058    0.0000 C   0  0
   -6.4924   -0.7585    0.0000 C   0  0
   -6.4955    0.7415    0.0000 C   0  0
   -5.1980    1.4942    0.0000 C   0  0
   -7.7905   -1.5116    0.0000 C   0  0
   -7.9276   -2.9925    0.0000 C   0  0
   -9.3947   -3.3051    0.0000 N   0  0
  -10.1453   -2.0065    0.0000 N   0  0
   -9.1422   -0.8913    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13  8  1  0
  8 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28528

> <plate>
Kinase v5-2

> <well>
I10

> <supplier_cmpd_name>
AT7867

> <ctcr_id>
3797

> <supplier_cmpd_id>
S1558

> <smiles>
Clc1ccc(cc1)C2(CCNCC2)c3ccc(cc3)c4c[nH]nc4

> <pd_targets>
{AKT2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase AKT family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Akt (Protein kinase B","PKB) family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by Insulin receptor","Insulin receptor signalling cascade","IRS-mediated signalling","PI3K Cascade","PKB-mediated events","PD
E3B signalling"}

> <broad_targets>
{AKT2,GSK3B,PKIA,PRKACA}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{AC-30293,AC30293,AT7867,857531-00-1,857531001,4-(4-chlorophenyl)-4-(4-(1H-pyrazol-4-yl)phenyl)piperidine,4(4chlorophenyl)4(4(1Hpyrazol4yl)phenyl)piperidine,AT-7867,4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-
chlorophenyl)piperidine,4(4(1Hpyrazol4yl)phenyl)4(4chlorophenyl)piperidine,UNII-ERF7YL2CE2,UNIIERF7YL2CE2,ERF7YL2CE2,"Piperidine, 4-(4-chlorophenyl)-4-(4-(1H-pyrazol-4-yl)phenyl)-","Piperidine, 4(4chl
orophenyl)4(4(1Hpyrazol4yl)phenyl)",AT,S1558}

> <pdid>
PD003534

> <targets>
{Akt,"S6 Kinase","S6 kinase",PKA,"Ribosomal S6 Kinase (RSK)"}

> <classes>
{PI3K/Akt/mTOR,MAPK/ERK Pathway,Protein Tyrosine Kinase/RTK,Stem Cell/Wnt}

> <pubchem_cids>
{11175137}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 28  0  0  0  0            999 V2000
    9.0755  -14.2726    0.0000 C   0  0
    9.0776  -12.7726    0.0000 C   0  0
    7.7794  -12.0195    0.0000 C   0  0
    7.7815  -10.5187    0.0000 C   0  0
    6.4833   -9.7656    0.0000 C   0  0
    6.4855   -8.2648    0.0000 C   0  0
    5.1873   -7.5117    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 N   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -4.0404    5.2322    0.0000 N   0  0
   -5.5083    5.5410    0.0000 N   0  0
   -6.2556    4.2405    0.0000 C   0  0
   -5.2496    3.1278    0.0000 S   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 16 19  1  0
 19 20  2  0
 19 21  2  0
 19 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28529

> <plate>
Kinase v5-2

> <well>
I12

> <supplier_cmpd_name>
PHT-427

> <ctcr_id>
2963

> <supplier_cmpd_id>
S1556

> <smiles>
CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc2nncs2

> <pd_targets>
{GAB1,ABCB11,AKT2,AKT1,PDPK1}

> <pathway_gtopdb>
{"Unclassified protein",Transporter,Enzyme,"Primary active transporter",Kinase,"ATP-binding cassette","Protein Kinase","ABCB subfamily","AGC protein kinase group","AGC protein kinase AKT family","AGC 
protein kinase PDK1 subfamily"}

> <pathway_chembl>
{Transporters,Enzymes,"ATP-binding cassette transporter family","Kinases (EC 2.7.x.x)","ABCB subfamily","AGC: Containing PKA",PKG,"PKC families","Akt (Protein kinase B","PKB) family","PDK1 family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","RNA Polymerase II Transcription","Signaling by FGFR","Metabolism of
 steroids","Signaling by Insulin receptor","Generic Transcription Pathway","Signaling by FGFR1","Bile acid and bile salt metabolism","Insulin receptor signalling cascade","Transcriptional Regulation b
y TP53","Downstream signaling of activated FGFR1","Synthesis of bile acids and bile salts","IRS-mediated signalling","Regulation of TP53 Activity","PI-3K cascade:FGFR1","Synthesis of bile acids and bi
le salts via 7alpha-hydroxycholesterol","PI3K Cascade","Regulation of TP53 Expression and Degradation","PKB-mediated events","Regulation of TP53 Degradation","PDE3B signalling"}

> <broad_targets>
{AKT2,PDPK1}

> <broad_moa>
{"AKT inhibitor","pyruvate dehydrogenase inhibitor"}

> <synonyms>
{HT42,PHT-427,PHT427,1191951-57-1,1191951571,"4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide","4dodecylN(1,3,4thiadiazol2yl)benzenesulfonamide","PHT 427",CHEMBL595583,C20H31N3O2S2,"4-Dodecyl-N-
1,3,4-thiadiazol-2-yl-benzenesulfonamide","4DodecylN1,3,4thiadiazol2ylbenzenesulfonamide","Benzenesulfonamide, 4-dodecyl-N-1,3,4-thiadiazol-2-yl-","Benzenesulfonamide, 4dodecylN1,3,4thiadiazol2yl",4-D
odecyl-N-(1,4DodecylN(1,T2420,S1556}

> <pdid>
PD010973

> <targets>
{"Akt | PDK-1",PDK-1,Akt}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{44240850}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 26  0  0  0  0            999 V2000
    1.2948   -3.7516    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8056   -3.8680    0.0000 N   0  0
   -3.3371   -5.2929    0.0000 N   0  0
   -1.8371   -5.2877    0.0000 C   0  0
   -0.9512   -6.4982    0.0000 C   0  0
   -1.3786   -3.8595    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8934   -5.2570    0.0000 N   0  0
    5.1924   -6.0070    0.0000 C   0  0
    6.4915   -5.2571    0.0000 C   0  0
    7.7905   -6.0071    0.0000 F   0  0
    6.4915   -3.7571    0.0000 C   0  0
    5.1925   -3.0070    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 11  2  0
  9 17  2  0
 17  4  1  0
  2 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28530

> <plate>
Kinase v5-2

> <well>
I14

> <supplier_cmpd_name>
AZD1480

> <ctcr_id>
6078

> <supplier_cmpd_id>
S2162

> <smiles>
CC(Nc1ncc(Cl)c(Nc2[nH]nc(C)c2)n1)c3ncc(F)cn3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{JAK1,JAK2,JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{SCHEMBL220400,CHEMBL2141865,CHEBI:91406,HMS3295G23,HMS3655D06,AKOS026750646,NCGC00389402-02,NCGC0038940202,AK313718,FT-0770690,FT0770690,BRD-A29009894-001-01-2,BRDA29009894001012,Q27163263,S2162,AZD1
480}

> <pdid>

> <targets>
{JAK}

> <classes>
{}

> <pubchem_cids>
{46861588}

$$$$
UTKinase_V5
  SciTegic11012413002D

 57 65  0  0  1  0            999 V2000
   -9.8785   -1.2799    0.0000 C   0  0
  -10.6159    0.0263    0.0000 C   0  0
   -9.8539    1.3170    0.0000 C   0  0
   -8.7906    1.7767    0.0000 C   0  0
   -7.6213    2.8080    0.0000 C   0  0
   -9.3949    5.3852    0.0000 C   0  0
   -9.0562    3.7760    0.0000 N   0  0
   -9.9666    2.2821    0.0000 C   0  0
   -7.2598    3.9925    0.0000 C   0  0
   -6.3969    4.7752    0.0000 C   0  0
   -5.0847    4.7896    0.0000 C   0  0
   -4.4469    5.9968    0.0000 N   0  0
   -5.4807    6.7939    0.0000 C   0  0
   -5.3783    7.9659    0.0000 C   0  0
   -6.4350    8.5643    0.0000 C   0  0
   -7.7902    7.7717    0.0000 C   0  0
   -7.7896    6.6020    0.0000 C   0  0
   -6.6978    6.0821    0.0000 C   0  0
   -4.6571    3.9977    0.0000 C   0  0  1  0  0  0
   -5.4925    3.1494    0.0000 C   0  0
   -3.4221    4.8504    0.0000 C   0  0
   -2.0670    4.2072    0.0000 O   0  0
   -3.5421    6.3465    0.0000 O   0  0
   -2.3077    7.1987    0.0000 C   0  0
   -4.0318    2.6323    0.0000 C   0  0
   -2.5657    2.5157    0.0000 C   0  0
   -1.9493    1.1329    0.0000 C   0  0
   -2.7823    0.0000    0.0000 C   0  0
   -4.2817    0.1000    0.0000 C   0  0
   -4.8982    1.4328    0.0000 C   0  0
   -6.3927    1.5708    0.0000 O   0  0
   -7.2597    0.3467    0.0000 C   0  0
   -1.9493   -1.2495    0.0000 N   0  0
   -2.4335   -2.6692    0.0000 C   0  0
   -0.5665   -0.7830    0.0000 C   0  0  1  0  0  0
    0.6997   -1.5161    0.0000 C   0  0  2  0  0  0
   -0.6257   -2.2184    0.0000 O   0  0
    2.0326   -0.7830    0.0000 C   0  0  2  0  0  0
    3.3301   -1.5369    0.0000 O   0  0
    3.3273   -3.0377    0.0000 C   0  0
    2.4602   -3.5358    0.0000 C   0  0
    4.6244   -3.7910    0.0000 O   0  0
    2.0326    0.6831    0.0000 C   0  0  2  0  0  0
    3.3312   -0.0685    0.0000 C   0  0
    4.1981    0.4300    0.0000 C   0  0
    3.2821    1.3995    0.0000 C   0  0
    3.2821    2.8989    0.0000 C   0  0
    1.5328    3.8485    0.0000 C   0  0
    0.4165    2.8656    0.0000 N   0  0
   -1.0329    3.0488    0.0000 C   0  0
   -1.6660    1.6994    0.0000 C   0  0
   -0.5665    0.6997    0.0000 C   0  0  2  0  0  0
    0.7331    1.4328    0.0000 C   0  0  2  0  0  0
    1.9918   -2.2373    0.0000 C   0  0
    1.9807   -3.2373    0.0000 O   0  0
    3.3001   -1.5018    0.0000 O   0  0
    4.5909   -2.2657    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 10  1  0
 18 13  1  0
 11 19  1  0
 19 20  1  0
 20  5  1  0
 19 21  1  6
 21 22  2  0
 21 23  1  0
 23 24  1  0
 19 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 30 31  1  0
 31 32  1  0
 28 33  1  0
 33 34  1  0
 35 33  1  6
 35 36  1  0
 36 37  1  1
 36 38  1  0
 38 39  1  1
 39 40  1  0
 40 41  1  0
 40 42  2  0
 38 43  1  0
 43 44  1  6
 44 45  1  0
 43 46  1  0
 46 47  2  3
 47 48  1  0
 48 49  1  0
 49 50  1  0
 50 51  1  0
 52 51  1  1
 52 27  1  0
 52 35  1  0
 52 53  1  0
 53 43  1  0
 53 49  1  1
 36 54  1  0
 54 55  2  0
 54 56  1  0
 56 57  1  0
M  END
> <name>
UTKinase_V5

> <id>
28531

> <plate>
Kinase v5-2

> <well>
I16

> <supplier_cmpd_name>
Vinorelbine(Navelbine)

> <ctcr_id>
7733

> <supplier_cmpd_id>
S1527

> <smiles>
CCC1=CC2CN(C1)Cc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@H]7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@H]89)C(=O)OC

> <pd_targets>
{KMT2A,MEN1,TUBA1A,TUBA1B,TUBA1C,TUBA3C,TUBA3E,TUBA4A,TUBB,TUBB1,TUBB2A,TUBB2B,TUBB3,TUBB4A,TUBB4B,TUBB6,TUBB8,FFP,ALD,CYP3A4,TACR2,TUBB5}

> <pathway_gtopdb>
{"Epigenetic regulator","Structural protein",Enzyme,"Membrane receptor",Reader,Transferase,"Cytochrome P450","Family A G protein-coupled receptor",Bromodomain,"Cytochrome P450 family 3","Peptide recep
tor (family A GPCR)","Cytochrome P450 family 3A","Short peptide receptor (family A GPCR)","Cytochrome P450 3A4","Neurokinin receptor"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets","Cytochrome P450","G protein-coupled receptors",Tubulins,"CYP3 family","Tachykinin receptors"}

> <pathway_reactome>
{Metabolism,"Signal Transduction","Cell Cycle","Metabolism of lipids","Signaling by GPCR",Mitotic,"Biosynthesis of specialized proresolving mediators (SPMs)","GPCR ligand binding","Mitotic G2-G2/M pha
ses","Biosynthesis of DHA-derived SPMs","Class A/1 (Rhodopsin-like receptors)","G2/M Transition","Biosynthesis of maresins","Peptide ligand-binding receptors","Centrosome maturation","Biosynthesis of 
maresin-like SPMs","Tachykinin receptors bind tachykinins","Loss of proteins required for interphase microtubule organization from the centrosome","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{TUBA1A,TUBA1B,TUBA1C,TUBA3C,TUBA3D,TUBA3E,TUBA4A,TUBB,TUBB1,TUBB2A,TUBB2B,TUBB3,TUBB4A,TUBB4B,TUBB6,TUBB8}

> <broad_moa>
{"tubulin polymerization inhibitor"}

> <synonyms>
{vinorelbine,alocrest,71486-22-1,71486221,inx-0125,inx0125,SCHEMBL1653160,SCHEMBL16786345,Pharmakon1600-01502272,Pharmakon160001502272,NSC760087,NSC-760087,NCGC00386325-01,NCGC0038632501,NCGC00482514-
01,NCGC0048251401,J-525161,J525161,S1527,Vinorelbine(Navelbine)}

> <pdid>
PD010080

> <targets>
{"p38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{60780}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    4.2146   -6.5095    0.0000 C   0  0
    3.3372   -5.2929    0.0000 C   0  0
    3.8056   -3.8679    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 C   0  0
    1.3039    3.7494    0.0000 N   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    3.9072    5.2405    0.0000 O   0  0
    3.9020    3.7405    0.0000 C   0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6588   -2.9478    0.0000 C   0  0
   -5.6590   -1.8298    0.0000 C   0  0
   -7.1272   -2.1369    0.0000 C   0  0
   -7.5954   -3.5619    0.0000 C   0  0
   -9.0636   -3.8690    0.0000 Cl  0  0
   -6.5954   -4.6799    0.0000 C   0  0
   -5.1271   -4.3729    0.0000 C   0  0
   -4.1271   -5.4909    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 N   0  0
    1.3786   -3.8595    0.0000 N   0  0
    1.8372   -5.2877    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 10  1  0
  8 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 18 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 22  1  0
 28 29  1  0
 20 30  1  0
 30 16  1  0
 30 31  1  0
 31  6  2  0
  4 32  2  0
 32 33  1  0
 33  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28532

> <plate>
Kinase v5-2

> <well>
I18

> <supplier_cmpd_name>
LY2784544

> <ctcr_id>
5527

> <supplier_cmpd_id>
S2179

> <smiles>
Cc1cc(Nc2cc(CN3CCOCC3)c4nc(C)c(Cc5ccc(Cl)cc5F)n4n2)n[nH]1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{GANDOTINIB,LY2784544,1229236-86-5,1229236865,"LY 2784544",LY-2784544,"Gandotinib (LY2784544)",UNII-ANC71R916O,UNIIANC71R916O,ANC71R916O,C23H25ClFN7O,"Gandotinib (USAN:INN)",LY2784544(Gandotinib),"Gan
dotinib (USAN)",cc-18,cc18,LY2784544;Gandotinib,Gandotinib(LY2784544),Gandot,T2638,S2179,Gandotinib}

> <pdid>

> <targets>
{JAK}

> <classes>
{JAK/STAT}

> <pubchem_cids>
{46213929}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    3.9015    0.7475    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    2.5972    1.5031    0.0000 C   0  0
    2.5951    3.0039    0.0000 N   0  0
    1.3787    3.8597    0.0000 C   0  0
    1.8375    5.2879    0.0000 N   0  0
    3.3367    5.2926    0.0000 C   0  0
    4.3367    6.4106    0.0000 C   0  0
    3.8684    7.8357    0.0000 N   0  0
    5.8050    6.1036    0.0000 N   0  0
    6.2732    4.6786    0.0000 C   0  0
    5.2732    3.5606    0.0000 N   0  0
    3.8050    3.8675    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17 11  1  0
 17 18  1  0
 18  8  1  0
 18 19  2  0
  9 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 21  1  0
 30 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28533

> <plate>
Kinase v5-2

> <well>
I20

> <supplier_cmpd_name>
IC-87114

> <ctcr_id>
6703

> <supplier_cmpd_id>
S1268

> <smiles>
Cc1ccccc1N2C(=Nc3cccc(C)c3C2=O)Cn4cnc5c(N)ncnc45

> <pd_targets>
{PIK3CD,PIK3CG,PIK3CB,PIK3R1}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{"Immune System",Metabolism,"Signal Transduction","Cytokine Signaling in Immune system","Metabolism of lipids","Signaling by Receptor Tyrosine Kinases","Signaling by Interleukins","Phospholipid metabo
lism","Signaling by Insulin receptor",Interleukin-3,"Interleukin-5 and GM-CSF signaling","PI Metabolism","Insulin receptor signalling cascade","Interleukin receptor SHC signaling","Synthesis of PIPs a
t the plasma membrane","IRS-mediated signalling","PI3K Cascade"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{C8711,IC-87114,IC87114,371242-69-2,371242692,2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one,2((6amino9Hpurin9yl)methyl)5methyl3otolylquinazolin4(3H)one,"IC 87114",UNII-9HC74
6B1KF,UNII9HC746B1KF,9HC746B1KF,CHEMBL1213082,CHEBI:90686,2-((6-aminopurin-9-yl)methyl)-5-methyl-3-(2-methylphenyl)quinazolin-4-one,2((6aminopurin9yl)methyl)5methyl3(2methylphenyl)quinazolin4one,D-030
,D030,T2660,S1268}

> <pdid>
PD003335

> <targets>
{PI3K}

> <classes>
{}

> <pubchem_cids>
{9908783}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 45  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.2559   -4.6520    0.0000 C   0  0
    5.8646   -6.1001    0.0000 N   0  0
    6.8064   -7.2685    0.0000 C   0  0
    8.2966   -7.1489    0.0000 C   0  0
    9.1474   -8.3843    0.0000 C   0  0
    8.5029   -9.7388    0.0000 N   0  0
    7.0076   -9.8579    0.0000 C   0  0
    6.1569   -8.6225    0.0000 C   0  0
    9.3516  -10.9766    0.0000 C   0  0
    8.7048  -12.3309    0.0000 C   0  0
    9.5513  -13.5693    0.0000 C   0  0
    8.9021  -14.9216    0.0000 C   0  0
    7.4064  -15.0355    0.0000 C   0  0
    6.5599  -13.7972    0.0000 C   0  0
    7.2091  -12.4449    0.0000 N   0  0
    4.3672   -6.1750    0.0000 C   0  0
    3.4207   -7.3387    0.0000 C   0  0
    1.9397   -7.1008    0.0000 C   0  0
    1.4052   -5.6993    0.0000 C   0  0
    2.3517   -4.5356    0.0000 C   0  0
    3.8327   -4.7735    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10  5  1  0
  4 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 12 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 24 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 20 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 39 18  1  0
 39 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28534

> <plate>
Kinase v5-2

> <well>
I22

> <supplier_cmpd_name>
Enzastaurin

> <ctcr_id>
3854

> <supplier_cmpd_id>
S1055

> <smiles>
Cn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4cn(C5CCN(CC5)Cc6ccccn6)c7ccccc47

> <pd_targets>
{PRKCA,DMPK,RPS6KA6,MET,RPS6KA4,MYLK4,MINK1,MAP4K1,CDK3,AXL,CDK7,PAK3,CLK1,CDK16,PRKG1,MELK,HIPK2,CLK4,PKN1,PRKCG,GRK7,PRKG2,AKT3,PRKCB,CAMK2D,PRKACA,CLK2,PIM1,RPS6KB1,CDKL2,STK17A,KIT,FLT3,PRKCH,TNK1
,RPS6KA5,PRKCE,PRKCZ,PRKCQ,STK26,MAP3K19,DYRK1B,PRKCD,PRKAA2,CDK14,PIP5K1C,FGFR1,PHKG1,JAK3,FLT4,TLK2,GSK3B,PRKACB,PIM3,CDK15,PDGFRB,RPS6KA1,RPS6KA3,CAMK2A,CAMK2B,CAMK2G,SLK,AAK1,STK33,MAPK15,STK3,DYR
K1A,HIPK4,NUAK2,CDK9,HIPK1,BMP2K,CAMKK2,STK16,CDK2,CILK1,GRK1,RPS6KA2,PIM2,TLK1}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","AGC protein kinase group","TK protein kinase group","CAMK protein kinase group","STE protein kinase group","CMGC protein kinase group","Other protein kinas
e group","AGC protein kinase PKC family","AGC protein kinase DMPK family","AGC protein kinase RSK family","Tyrosine protein kinase Met family","CAMK protein kinase MLCK family","STE protein kinase STE
20 family","CMGC protein kinase CDK family","Tyrosine protein kinase Axl family","CMGC protein kinase CLK family","AGC protein kinase PKG family","CAMK protein kinase CAMK1 family","CMGC protein kinas
e DYRK family","AGC protein kinase PKN family","AGC protein kinase GRK family","AGC protein kinase AKT family","CAMK protein kinase CAMK2 family","AGC protein kinase PKA family","CAMK protein kinase P
IM family","CMGC protein kinase CDKL family","CAMK protein kinase DAPK family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Ack family","STE protein kinase STE11 family","Tyrosine p
rotein kinase FGFR family","CAMK protein kinase PHk family","Tyrosine protein kinase JakA family","Tyrosine protein kinase VEGFR family","Other protein kinase TLK family","CMGC protein kinase GSK fami
ly","Other protein kinase NAK family","CAMK protein kinase unique family","CMGC protein kinase MAPK family","Other protein kinase CAMKK family","CMGC protein kinase RCK family","AGC protein kinase PKC
 alpha subfamily","AGC protein kinase GEK subfamily","AGC protein kinase RSK subfamily","AGC protein kinase MSK subfamily","STE protein kinase MSN subfamily","STE protein kinase KHS subfamily","CMGC p
rotein kinase CDC2 subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase PAKA subfamily","CMGC protein kinase TAIRE subfamily","CAMK protein kinase MELK subfamily","CMGC protein kinase H
IPK subfamily","AGC protein kinase GRK subfamily","AGC protein kinase p70 subfamily","AGC protein kinase PKC eta subfamily","AGC protein kinase PKC iota subfamily","AGC protein kinase PKC delta subfam
ily","STE protein kinase YSK subfamily","CMGC protein kinase Dyrk1 subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase PFTAIRE","STE protein kinase SLK subfamily","STE protein kinase 
MST subfamily","CAMK protein kinase NuaK subfamily","CMGC protein kinase CDK9 subfamily","Other protein kinase Meta subfamily","CMGC protein kinase MAK"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast
 Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Lipid modifying kinases","Protein kinase C (PKC) family","DMPK family","RSK family","TK: Tyrosine kinase"
,"Myosin Light Chain Kinase (MLCK) family","STE20 family","Cyclin-dependent kinase (CDK) family","CLK family","Protein kinase G (PKG) family","CAMK-like (CAMKL) family","Dual-specificity tyrosine-(Y)-
phosphorylation regulated kinase (DYRK) family","Protein kinase N (PKN) family","G protein-coupled receptor kinases (GRKs)","Akt (Protein kinase B","PKB) family","CAMK2 family","Protein kinase A (PKA)
 family","PIM family","Cyclin-dependent kinase-like (CDKL) family","Death-associated kinase (DAPK) family","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","Phosphorylase kina
se (PHK) family","Other protein kinases","Glycogen synthase kinase (GSK) family","CAMK-unique family","Mitogen-activated protein kinases (MAP kinases)","RCK family","Delta subfamily","GEK subfamily","
RSK subfamily","Receptor tyrosine kinases (RTKs)","MSK subfamily","MSN subfamily","KHS subfamily","CDK1 subfamily","CDK7 subfamily","PAKA subfamily","TAIRE subfamily","MELK subfamily","HIPK subfamily"
,"Alpha subfamily","Opsin/rhodopsin kinases","p70 subfamily","Eta subfamily","Non-receptor tyrosine kinases (nRTKs)","Iota subfamily","YSK subfamily","STE20 subfamily","Dyrk1 subfamily","AMPK subfamil
y","Tousled-like kinase (TLK) family","GSK subfamily","SLK subfamily","NAK family","Erk7 subfamily","MST subfamily","NuaK subfamily","CDK9 subfamily","Numb-associated kinase (NAK) family","CAMKK famil
y","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Ack family","Typ
e V RTKs: FGF (fibroblast growth factor) receptor family","Janus kinase (JakA) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Meta subfamily"}

> <pathway_reactome>
{"Signal Transduction","Muscle contraction","Neuronal System","Developmental Biology","Cellular responses to external stimuli",Disease,Hemostasis,"Gene expression (Transcription)","Cell Cycle","Immune
 System","Programmed Cell Death",Metabolism,"Vesicle-mediated transport","Signaling by GPCR","Cardiac conduction","Transmission across Chemical Synapses","Nervous system development","Cellular respons
es to stress","Signaling by Receptor Tyrosine Kinases","Infectious disease","Platelet homeostasis","RNA Polymerase II Transcription","Signaling by Rho GTPases","MAPK family signaling cascades",Mitotic
,"Diseases of signal transduction by growth factor receptors and second messengers","MTOR signalling","Innate Immune System","Signaling by Nuclear Receptors",Apoptosis,"Intracellular signaling by seco
nd messengers","Metabolism of carbohydrates","Cytokine Signaling in Immune system","Membrane Trafficking","Signaling by Hippo","GPCR downstream signalling","Ion homeostasis","Neurotransmitter receptor
s and postsynaptic signal transmission","Axon guidance","Cellular Senescence","Signaling by VEGF","HIV Infection","Nitric oxide stimulates guanylate cyclase","Generic Transcription Pathway","RHO GTPas
e Effectors","MAPK1/MAPK3 signaling","M Phase","Mitotic G2-G2/M phases","FLT3 signaling in disease","mTORC1-mediated signalling","Signaling by KIT in disease","Signaling by Insulin receptor","Toll-lik
e Receptor Cascades","Fcgamma receptor (FCGR) dependent phagocytosis","ESR-mediated signaling","Apoptotic execution phase","Signaling by FGFR in disease","DAG and IP3 signaling","Glycogen metabolism",
"Signaling by Interleukins","SARS-CoV Infections","PIP3 activates AKT signaling","Clathrin-mediated endocytosis","Mitotic G1 phase and G1/S transition","G alpha (i) signalling events","Activation of N
MDA receptors and postsynaptic events","Semaphorin interactions","L1CAM interactions","Oxidative Stress Induced Senescence","VEGFA-VEGFR2 Pathway","HIV Life Cycle","EPH-Ephrin signaling","cGMP effects
","Transcriptional Regulation by TP53","RHO GTPases activate PKNs","Glutamate binding","activation of AMPA receptors and synaptic plasticity","RAF/MAP kinase cascade","Mitotic Prophase","G2/M Transiti
on","Signaling by FLT3 ITD and TKD mutants","Drug resistance of KIT mutants","Insulin receptor signalling cascade","G alpha (z) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Role of phosph
olipids in phagocytosis","Extra-nuclear estrogen signaling","Apoptotic cleavage of cellular proteins","Signaling by FGFR1 in disease","CaM pathway","Glycogen breakdown (glycogenolysis)","Interleukin-2
 family signaling","VEGF ligand-receptor interactions","SARS-CoV-1 Infection","Negative regulation of the PI3K/AKT network","Cargo recognition for clathrin-mediated endocytosis","G0 and Early G1","Vis
ual phototransduction","Post NMDA receptor activation events","Sema4D in semaphorin signaling","Recycling pathway of L1","Late Phase of HIV Life Cycle","Ephrin signaling","Regulation of TP53 Activity"
,"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Trafficking of AMPA receptors","RAS processing","Nuclear Envelope Breakdown","Centrosome maturation"
,"STAT5 activation downstream of FLT3 ITD mutants","Dasatinib-resistant KIT mutants","IRS-mediated signalling","MyD88 cascade initiated on plasma membrane","Estrogen-stimulated signaling through PRKCZ
","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","FGFR1 mutant receptor activation","Calmodulin induced events","Interleukin-15 signaling","VEGF binds to VEGFR leading to receptor
 dimerization","SARS-CoV-1 Genome Replication and Transcription",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","The phototransduction cascade","CREB1 phosphorylation through NMDA receptor-mediated 
activation of RAS signaling","Sema4D mediated inhibition of cell attachment and migration","Transcription of the HIV genome","Regulation of TP53 Activity through Phosphorylation","Trafficking of GluR2
-containing AMPA receptors","Regulation of TP53 Expression and Degradation","Depolymerisation of the Nuclear Lamina","Loss of proteins required for interphase microtubule organization from the centros
ome","PI3K Cascade","MAP kinase activation","Signaling by activated point mutants of FGFR1","Replication of the SARS-CoV-1 genome","PKA-mediated phosphorylation of CREB","Activation of AMPK downstream
 of NMDARs",Inactivation,"recovery and regulation of the phototransduction cascade","RSK activation","HIV Transcription Elongation","Regulation of TP53 Degradation","Ras activation upon Ca2+ influx th
rough NMDA receptor","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","PKA activation","Tat-mediated elongation of the HIV-1 transcript","CREB phosphorylat
ion","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{AKT1,GSK3B,PRKCA,PRKCB,PRKCD,PRKCG}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{Enzastaurin,170364-57-5,170364575,"Enzastaurin (LY317615)",LY317615,LY-317615,UNII-UC96G28EQF,UNIIUC96G28EQF,"Enzastaurin free base",UC96G28EQF,"LY 317615",CHEMBL300138,"170364-57-5 (free base)","170
364575 (free base)",DSSTox_CID_24029,DSSToxCID24029,DSSTox-CID-24029,"DSSTox CID 24029",DSSTox_RID_80101,DSSToxRID80101,DSSTox-RID-80101,"DSSTox RID 80101",DSSTox_GSID_44029,DSSToxGSID44029,DSSTox-GSI
D-44029,"DSSTox GSID 44029",C32H29N5O2,CAS-170364,CAS170364,T6280,S1055,ENZASTAURIN}

> <pdid>
PD003282

> <targets>
{PKC,"PKC-beta Inhibitors",Apoptosis,Autophagy}

> <classes>
{Apoptosis,Autophagy,Epigenetics,TGF-beta/Smad}

> <pubchem_cids>
{176167}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 42  0  0  1  0            999 V2000
   -1.7668    6.0997    0.0000 C   0  0
   -2.5381    4.8132    0.0000 N   0  0
   -1.8100    3.5000    0.0000 C   0  0  2  0  0  0
   -0.2400    3.5200    0.0000 C   0  0
    0.5000    2.1800    0.0000 C   0  0  1  0  0  0
   -1.0600    2.1800    0.0000 O   0  0
   -1.8300    0.9300    0.0000 C   0  0  1  0  0  0
   -3.1401    0.1996    0.0000 C   0  0
   -2.6500    2.2500    0.0000 C   0  0  2  0  0  0
   -4.1488    2.2849    0.0000 O   0  0
   -4.9300    1.0044    0.0000 C   0  0
   -0.9800   -0.7800    0.0000 N   0  0
   -2.1300   -1.4600    0.0000 C   0  0
   -3.3200   -0.7600    0.0000 C   0  0
   -4.5500   -1.4800    0.0000 C   0  0
   -4.5800   -2.7700    0.0000 C   0  0
   -3.3400   -3.4700    0.0000 C   0  0
   -2.1300   -2.7900    0.0000 C   0  0
    0.2400   -2.7700    0.0000 C   0  0
    1.4300   -3.4700    0.0000 C   0  0
    1.7600   -4.9700    0.0000 C   0  0
    3.2600   -5.0800    0.0000 N   0  0
    3.8500   -3.6300    0.0000 C   0  0
    5.2941   -3.2244    0.0000 O   0  0
    2.6600   -2.7500    0.0000 C   0  0
    2.6800   -1.4600    0.0000 C   0  0
    3.7900    0.5600    0.0000 C   0  0
    4.9600    1.2800    0.0000 C   0  0
    4.9600    2.6300    0.0000 C   0  0
    3.8100    3.2900    0.0000 C   0  0
    2.6400    2.5900    0.0000 C   0  0
    2.6400    1.2400    0.0000 C   0  0
    1.4900    0.5400    0.0000 N   0  0
    1.4500   -0.7600    0.0000 C   0  0
    0.2400   -1.4400    0.0000 C   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  5  4  1  6
  5  6  1  0
  6  7  1  0
  7  8  1  1
  7  9  1  0
  9  3  1  0
  9 10  1  6
 10 11  1  0
  7 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 20  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 32 33  1  0
 33  5  1  0
 33 34  1  0
 34 26  1  0
 34 35  2  0
 35 12  1  0
 35 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28535

> <plate>
Kinase v5-2

> <well>
TRUE

> <supplier_cmpd_name>
Staurosporine

> <ctcr_id>
3125

> <supplier_cmpd_id>
S1421

> <smiles>
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

> <pd_targets>
{HUNK,MAP2K1,RAF1,TNIK,GSK3B,EGFR,MAPK1,MYLK,LCK,CCND1,CDK4,KDR,CDK2,RPS6KA2,MARK2,RPS6KA5,CAMK1D,CDK6,PIM2,NEK2,MAP3K5,PTK2,PIM1,STK3,PIP5K1A,RPS6KA6,MAP3K13,STK25,PRKACB,PRKX,CSNK1A1L,CSNK1D,TLK1,TL
K2,RIPK4,MAP3K19,DYRK1A,NEK11,SBK3,CDPK1,CCNE1,CDK3,CCNA2,CSNK1A1,CSNK1E,CSNK1G1,CSNK1G2,IGF1R,PRKACA,PRKCG,ABL1,MYO3B,FRK,AURKC,MAPK10,STK36,YES1,PLK4,FLT3,KIT,FLT4,PDGFRB,FGFR3,AURKA,MET,JAK3,TYRO3,
PDGFRA,CCNB1,CDK1,CCNT1,CDK9,CHUK,ZAP70,CHEK2,DAPK1,FLT1,NUAK1,PIM3,MAP4K3,AURKB,BLK,MAP4K4,MAP3K10,MAP3K11,MUSK,DCLK1,DCLK3,MYO3A,ULK3,STK32A,ERN1,MST1R,NEK4,RPS6KB1,ULK1,DYRK2,CDK13,ROCK2,MAP3K1,STK
38,CILK1,CCNO,DYRK3,KSR2,PRKCA,PRKCB,PRKCD,PRKCE,PRKCH,PRKCQ,PRKCZ,SRC,FGR,MAPK9,LYN,BTK,EPHA3,CDK7,SLK,RIPK2,EPHA4,EPHA5,PRKAA1,PHKG2,FYN,FGFR2,PAK5,CAMK2B,PAK3,CAMK2G,CAMKK1,AKT1,AKT3,TGFBR1,CHEK1,M
APKAPK2,MAPK3,LIMK2,MARK3,MAP2K2,STK26,INSRR,ITK,JAK1,RIOK3,SRPK1,ACVR1B,SRPK2,TNK1,ALK,DDR2,DMPK,LATS1,EPHA1,PKN1,PKN2,PLK1,MAPK7,MAPK15,PRKD2,HIPK4,PRKG2,PTK6,PDK1,PRKACG,CCNE2,MAP2K4,MAP2K6,IKBKB,G
RK4,HCK,STK17A,MAP3K4,CLK1,CLK4,MAPK8,CAMKK2,CAMK1G,TEC,NIM1K,CDK5,CDK5R1,ERBB4,HIPK1,AXL,BRAF,MARK1,MARK4,MERTK,CDK8,MAP3K9,CDC42BPA,STK24,CIT,MAP2K5,MAPT,GRK1,HIPK3,MAP3K12,SRPK3,GRK6,SGK1,MAPKAPK3,
PRKCI,MAPK12,STK4,DAPK2,STK16,DAPK3,CLK2,NTRK1,NEK9,CLK3,DSTYK,LIMK1,MYLK2,TNK2,PAK2,PLK2,RET,CCNH,CHRM1,ROCK1,RPS6KA1,TAB1,ROS1,CDK18,CDK14,STK32C,NTRK2,NTRK3,GSK3A,CDK15,STK38L,CDK16,FER,MAP3K7,CDK1
7,PTK2B,TIE1,TYK2,TAOK3,TAOK1,HIPK2,LRRK2,CCNK,CCNA1,EPHA7,EPHB1,DDR1,MKNK2,STK10,EPHA6,FGFR1,TEK,EPHA2,JAK2,PAK4,SYK,PAK1,CAMK2D,PAK6,IKBKE,NEK7,EIF2AK4,STK32B,PFMRK,LATS2,CDC42BPG,NEK1,SIK1,TESK1,PL
K3,EPHB2,ERBB2,PRKD1,PRKG1,MAK,FGFR4,RPS6KA4,PKN3,TSSK6,CAMK2A,PRKD3,AKT2,TBK1,STK11,MAP2K3,MAPK14,SIK2,STK33,TNNI3K,LTK,ANKK1,OSR1,CSNK2A1,CSNK2A2,CSNK2B,CCNB2,CCNB3,INSR,STK17B,CAMK1,IRAK4,BMPR1A,BR
SK1,CAMK4,CDK19,CSF1R,DCLK2,SIK3,CCNC,CCND3,CCNT2,GRK5,CSK,AAK1,BMPR2,CDC42BPB,RECQL,KMT2A,MEN1,MAP3K15,SBK1,BMPR1B,PI4KB,MAPK13,CDKL5,PRPF4B,CDKL1,MAP3K2,SGK3,BCR,CDC7,DBF4,CCNY,HASPIN,KSR1,TTK,RPS6K
A3,MINK1,MYLK4,PIP4K2B,DYRK1B,MAP2K7,MYLK3,PDPK1,STK35,BMP2K,MAP4K5,ABL2,EPHA8,MELK,MKNK1,IRAK3,ACVR1,ACVR2A,NEK5,BRSK2,NUAK2,FES,RPS6KB2,WNK2,MAPKAPK5,MAP3K3,PIK3CG,MAP3K6,STK39,TAOK2,ABCB11,MNAT1,NL
K,ACVR2B,TSSK1B,PRKAA2,ACVRL1,SRMS,TUBA1A,MAPK6,EIF2AK2,SGK2,TSSK2,WNK1,CHRM2,KARS1,CSNK1G3,TXK,SNRK,GRK7,EPHB4,MAP4K1,IRAK1,EPHB6,PIP5K1C,ULK2,MAST1,ERBB3,PNCK,BMX,GAK,PHKG1,EPHB3,NEK8,PBK,PEAK1,CHRM
4,RIOK2,PKNB,CRK2,PHKA1,PHKA2,PHKB,ALDH1A1,MATK,CASK,CDKL2,PIK3C2G,ERN2,GRK2,GRK3,MAP3K21,WEE1,RIOK1,PASK,TSSK3,PIK3CA,CDKL3,NEK3,MAP4K2,OXSR1,GCK,CYP11B2,TERT,MAP3K14,CDK12,RB1,ABCC4}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Membrane receptor","Unclassified protein","Epigenetic regulator",Transporter,"Structural protein",Kinase,Transferase,"Family A G protein-coupled receptor",Reader,"Pr
imary active transporter",Oxidoreductase,"Cytochrome P450","Protein Kinase","Small molecule receptor (family A GPCR)",Bromodomain,"ATP-binding cassette","Cytochrome P450 family 11","CAMK protein kinas
e group","STE protein kinase group","CMGC protein kinase group","TK protein kinase group","AGC protein kinase group","Other protein kinase group","TKL protein kinase group","CK1 protein kinase group",
"Atypical protein kinase group","Monoamine receptor","ABCB subfamily","Cytochrome P450 family 11B","ABCC subfamily","STE protein kinase STE7 family","STE protein kinase STE20 family","CMGC protein kin
ase GSK family","Tyrosine protein kinase EGFR family","CMGC protein kinase MAPK family","CAMK protein kinase MLCK family","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","C
MGC protein kinase CDK family","AGC protein kinase RSK family","CAMK protein kinase CAMK1 family","CAMK protein kinase PIM family","Other protein kinase NEK family","STE protein kinase STE11 family","
Tyrosine protein kinase Fak family","TKL protein kinase MLK family","AGC protein kinase PKA family","CK1 protein kinase CK1 family","Other protein kinase TLK family","TKL protein kinase RIPK family","
CMGC protein kinase DYRK family","Other protein kinase NKF1 family","Tyrosine protein kinase InsR family","AGC protein kinase PKC family","Tyrosine protein kinase Abl family","Other protein kinase AUR
 family","Other protein kinase ULK family","Other protein kinase PLK family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase Met family","Tyrosine
 protein kinase JakA family","Tyrosine protein kinase Axl family","Other protein kinase IKK family","Tyrosine protein kinase Syk family","CAMK protein kinase RAD53 family","CAMK protein kinase DAPK fa
mily","Tyrosine protein kinase Musk family","CAMK protein kinase DCAMK1 family","AGC protein kinase YANK family","AGC protein kinase DMPK family","AGC protein kinase NDR family","CMGC protein kinase R
CK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Eph family","CAMK protein kinase PHk family","CAMK protein kinase CAMK2 family","Other protein kinase CAMKK family","AGC protei
n kinase AKT family","TKL protein kinase STKR family","CAMK protein kinase MAPKAPK family","TKL protein kinase RAF family","TKL protein kinase LISK family","Atypical protein kinase RIO family","CMGC p
rotein kinase SRPK family","Tyrosine protein kinase Ack family","Tyrosine protein kinase DDR family","AGC protein kinase PKN family","CAMK protein kinase PKD family","AGC protein kinase PKG family","A
typical protein kinase PDHK subfamily","AGC protein kinase GRK family","CMGC protein kinase CLK family","AGC protein kinase SGK family","Other protein kinase NAK family","Tyrosine protein kinase Trk f
amily","Tyrosine protein kinase Ret family","Acetylcholine receptor","Tyrosine protein kinase Sev family","Tyrosine protein kinase Fer family","Tyrosine protein kinase Tie family","TKL protein kinase 
LRRK family","Other protein kinase PEK family","CAMK protein kinase TSSK family","CAMK protein kinase unique family","Tyrosine protein kinase Alk family","Other protein kinase CK2 family","TKL protein
 kinase IRAK family","Tyrosine protein kinase Csk family","CMGC protein kinase CDKL family","Atypical protein kinase BCR family","Other protein kinase CDC7 family","Other protein kinase Haspin family"
,"Other protein kinase TTK family","AGC protein kinase PDK1 subfamily","Other protein kinase NKF4 family","Other protein kinase Wnk family","AGC protein kinase MAST family","Other protein kinase TOPK 
family","Other protein kinase WEE family","Cytochrome P450 11B2","STE protein kinase unique family","STE protein kinase MSN subfamily","CMGC protein kinase ERK1","CMGC protein kinase CDC2 subfamily","
AGC protein kinase RSK subfamily","CAMK protein kinase MARK subfamily","AGC protein kinase MSK subfamily","STE protein kinase MST subfamily","TKL protein kinase LZK subfamily","STE protein kinase YSK 
subfamily","CK1 protein kinase CK1-a","CMGC protein kinase Dyrk1 subfamily","Other protein kinase Nek11","AGC protein kinase PKC alpha subfamily","STE protein kinase NinaC subfamily","CMGC protein kin
ase JNK subfamily","CMGC protein kinase CDK9 subfamily","CAMK protein kinase NuaK subfamily","STE protein kinase KHS subfamily","TKL protein kinase MLK subfamily","AGC protein kinase p70 subfamily","C
MGC protein kinase Dyrk2 subfamily","AGC protein kinase ROCK subfamily","CMGC protein kinase MAK","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase SLK 
subfamily","CAMK protein kinase AMPK subfamily","Tyrosine protein kinase SrcA","STE protein kinase PAKB subfamily","STE protein kinase PAKA subfamily","Other protein kinase Meta subfamily","TKL protei
n kinase STKR Type 1 subfamily","CAMK protein kinase CHK1 subfamily","CAMK protein kinase MAPKAPK subfamily","TKL protein kinase LIMK subfamily","Atypical protein kinase RIO3 subfamily","AGC protein k
inase GEK subfamily","CMGC protein kinase ERK5","CMGC protein kinase HIPK subfamily","AGC protein kinase GRK subfamily","CAMK protein kinase NIM1 subfamily","CMGC protein kinase CDK8 subfamily","AGC p
rotein kinase CRIK subfamily","AGC protein kinase PKC iota subfamily","CMGC protein kinase p38 subfamily","Other protein kinase PLK2","CMGC protein kinase PCTAIRE","CMGC protein kinase PFTAIRE","CMGC 
protein kinase TAIRE subfamily","CMGC protein kinase CDK5 subfamily","TKL protein kinase TAK1 subfamily","STE protein kinase TAO subfamily","AGC protein kinase PKC eta subfamily","CAMK protein kinase 
MNK subfamily","Other protein kinase GCN2 subfamily","CAMK protein kinase QIK subfamily","TKL protein kinase TESK subfamily","CAMK protein kinase LKB subfamily","TKL protein kinase HH498 subfamily","C
AMK protein kinase BRSK subfamily","TKL protein kinase STKR Type 2 subfamily","STE protein kinase ASK","STE protein kinase MEKK2","CAMK protein kinase MELK subfamily","TKL protein kinase STKR1","STE p
rotein kinase FRAY subfamily","CMGC protein kinase nmo subfamily","Tyrosine protein kinase Srm","CMGC protein kinase ERK3","Other protein kinase PKR","CK1 protein kinase CK1-g","Atypical protein kinas
e RIO2 subfamily","AGC protein kinase BARK subfamily","Atypical protein kinase RIO1 subfamily","CAMK protein kinase PASK subfamily","Other protein kinase Nek1"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Other protein targets","Kinases (EC 2.7.x.x)","Catalytic receptors","G protein-coupled receptors","ATP-binding cassette transporter family",Tubulins,"Cytochrome P450",
"CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","AGC: Conta
ining PKA",PKG,"PKC families","Lipid modifying kinases","CK1: Casein kinase 1",Atypical,"Acetylcholine receptors (muscarinic)","ABCB subfamily","Miscellaneous protein kinases",CYP11,CYP17,CYP19,"CYP20
 and CYP21 families","ABCC subfamily","CAMK-like (CAMKL) family","STE20 family","Glycogen synthase kinase (GSK) family","TK: Tyrosine kinase","STE7 family","Mitogen-activated protein kinases (MAP kina
ses)","Myosin Light Chain Kinase (MLCK) family","Cyclin-dependent kinase (CDK) family","RSK family","CAMK1 family","PIM family","Other protein kinases","STE11 family","Type I PIP kinases (1-phosphatid
ylinositol-4-phosphate 5-kinase family)","TKL: Tyrosine kinase-like","Protein kinase A (PKA) family","Casein kinase 1 (CK1) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYR
K) family","Protein kinase C (PKC) family","Death-associated kinase (DAPK) family","DCAMKL family","YANK family","DMPK family","NDR family","RCK family","Phosphorylase kinase (PHK) family","CAMK2 fami
ly","Akt (Protein kinase B","PKB) family","MAPK-Activated Protein Kinase (MAPKAPK) family","RIO family","SRPK family","Protein kinase N (PKN) family","Protein kinase D (PKD) family","Protein kinase G 
(PKG) family","PDHK family","G protein-coupled receptor kinases (GRKs)","CLK family","SGK family","Testis specific kinase (TSSK) family","CAMK-unique family","1-phosphatidylinositol 4-kinase family","
Cyclin-dependent kinase-like (CDKL) family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","PDK1 family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","MAST famil
y","CASK family","Phosphatidylinositol-4-phosphate 3-kinase family",Hexokinases,"STE-unique family","HUNK subfamily","MSN subfamily","GSK subfamily","Receptor tyrosine kinases (RTKs)","ERK subfamily",
"Non-receptor tyrosine kinases (nRTKs)","CDK1 subfamily","RSK subfamily","MARK subfamily","MSK subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","MST subfamily","Mixed Lineage K
inase (MLK) family","YSK subfamily","Tousled-like kinase (TLK) family","Receptor interacting protein kinase (RIPK) family","STE20 subfamily","Dyrk1 subfamily","NKF1 family","Alpha subfamily","NinaC su
bfamily","Aurora kinase (Aur) family","JNK subfamily","Unc-51-like kinase (ULK) family","Polo-like kinase (PLK) family","IKK family","CHK1 subfamily","NuaK subfamily","KHS subfamily","IRE family","p70
 subfamily","Dyrk2 subfamily","CRK7 subfamily","Rho kinase","RAF family","Delta subfamily","CDK7 subfamily","SLK subfamily","AMPK subfamily","PAKB subfamily","PAKA subfamily","CAMKK family","Receptor 
serine/threonine kinase (RSTK) family","MAPKAPK subfamily","LIM domain kinase (LISK) family","RIO3 subfamily","GEK subfamily","Erk7 subfamily","HIPK subfamily","GRK4 subfamily","NIM1 subfamily","CDK8 
subfamily","Other DMPK family kinases","Opsin/rhodopsin kinases","Iota subfamily","p38 subfamily","NAK family","Other-unique family","TAIRE subfamily","CDK5 subfamily","TAO subfamily","Leucine-rich re
peat kinase (LRRK) family","Eta subfamily","MKN subfamily","PEK family","QIK subfamily","LKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","BRSK subfamily","CDK4 subfamily","PRP4
 subfamily","Haspin family","TTK family","Casein kinase 2 (CK2) family","NKF4 family","Numb-associated kinase (NAK) family","MELK subfamily","Wnk family","FRAY subfamily","nmo subfamily","CDK9 subfami
ly","SNRK subfamily","TOPK family","RIO2 subfamily","Beta-adrenergic receptor kinases (&beta;ARKs)","WEE family","RIO1 subfamily","PASK subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor
 family","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Fak family","LZK subfamily","Type II RTKs: Insulin receptor family","Abl family","Type III RTKs: PDGFR"
,CSFR,Kit,"FLT3 receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Janus kinase (JakA) family","Type XI RTKs:
 TAM (TYRO3-","AXL- and MER-TK) receptor family","Syk family","MLK subfamily","Type IX RTKs: MuSK","Tec family","Type XIII RTKs: Ephrin receptor family","Meta subfamily","Type I receptor serine/threon
ine kinases","LIMK subfamily","Ack family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Type VII RTKs: Neurotrophin receptor/Trk fa
mily","Type XIV RTKs: RET","Type XVII RTKs: ROS receptors","Fer family","TAK1 subfamily","Type XII RTKs: TIE family of angiopoietin receptors","GCN2 subfamily","TESK subfamily","HH498 subfamily","Csk 
family","Type II receptor serine/threonine kinases","Other PEK family kinases"}

> <pathway_reactome>
{"Cellular responses to external stimuli",Disease,"Signal Transduction","Immune System","Gene expression (Transcription)","Cell Cycle",Metabolism,"Neuronal System","Developmental Biology","Programmed 
Cell Death","Extracellular matrix organization","Metabolism of proteins",Autophagy,"DNA Repair","Metabolism of RNA","Muscle contraction","Organelle biogenesis and maintenance",Hemostasis,"Circadian Cl
ock","Cell-Cell communication","Vesicle-mediated transport","Transport of small molecules","Cellular responses to stress","Infectious disease","Signaling by GPCR","Signaling by Receptor Tyrosine Kinas
es","Innate Immune System","Signaling by Rho GTPases","RNA Polymerase II Transcription",Mitotic,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Hippo",
"Metabolism of lipids","Transmission across Chemical Synapses","Intracellular signaling by second messengers","Nervous system development","Cytokine Signaling in Immune system","Adaptive Immune System
",Apoptosis,"ECM proteoglycans","Signaling by Hedgehog","Unfolded Protein Response (UPR)","MTOR signalling",Macroautophagy,"Metabolism of carbohydrates","DNA Double-Strand Break Repair","MAPK family s
ignaling cascades","rRNA processing","Signaling by NODAL","Non-integrin membrane-ECM interactions","Cardiac conduction","The citric acid (TCA) cycle and respiratory electron transport","Cilium Assembl
y","Cell surface interactions at the vascular wall","Death Receptor Signalling","Signaling by Non-Receptor Tyrosine Kinases","Cell junction organization","Platelet homeostasis","Signaling by TGFB fami
ly members","Disorders of Developmental Biology","Membrane Trafficking","Ion channel transport","Signaling by WNT",Translation,"Biological oxidations","Cell Cycle Checkpoints","Signaling by Nuclear Re
ceptors","Chromosome Maintenance","Platelet activation","signaling and aggregation","Cellular Senescence","SARS-CoV Infections","GPCR downstream signalling","Signaling by NTRKs","Toll-like Receptor Ca
scades","RHO GTPase Effectors","HIV Infection","Signaling by VEGF","Generic Transcription Pathway","Regulation of mitotic cell cycle","Leishmania infection","FLT3 signaling in disease","Phospholipid m
etabolism","Neurotransmitter receptors and postsynaptic signal transmission","DAG and IP3 signaling","Mitotic G2-G2/M phases","Mitotic G1 phase and G1/S transition","Signaling by Type 1 Insulin-like G
rowth Factor 1 Receptor (IGF1R)","PIP3 activates AKT signaling","Signaling by Insulin receptor","Signaling by KIT in disease","Signaling by FGFR in disease","Axon guidance","Signaling by Interleukins"
,"Signaling by PDGFR in disease","TCR signaling","Caspase activation via extrinsic apoptotic signalling pathway","M Phase","Oncogenic MAPK signaling","Hedgehog 'on' state","IRE1alpha activates chapero
nes","Signaling by MST1","mTORC1-mediated signalling","Selective autophagy","Glycogen metabolism","Signaling by TGF-beta Receptor Complex in Cancer","Homology Directed Repair","MAPK1/MAPK3 signaling",
"Apoptotic execution phase","Interferon Signaling","rRNA processing in the nucleus and cytosol","Regulation of signaling by NODAL","Ion homeostasis","Sphingolipid metabolism","Signaling by WNT in canc
er","Pyruvate metabolism and Citric Acid (TCA) cycle","Anchoring of the basal body to the plasma membrane","Signaling by NOTCH1 in Cancer","p75 NTR receptor-mediated signalling","GPCR ligand binding",
"Signaling by SCF-KIT","Signaling by PTK6","Fcgamma receptor (FCGR) dependent phagocytosis","Neutrophil degranulation","Response of EIF2AK4 (GCN2) to amino acid deficiency","Cell-extracellular matrix 
interactions","Nitric oxide stimulates guanylate cyclase","Signaling by FGFR","Signaling by BMP","Disorders of Nervous System Development","Regulation of lipid metabolism by PPARalpha","Clathrin-media
ted endocytosis","Stimuli-sensing channels","PI3K/AKT Signaling in Cancer","Metabolism of steroids","Beta-catenin independent WNT signaling","MAPK6/MAPK4 signaling","Influenza Infection","tRNA Aminoac
ylation","Fc epsilon receptor (FCERI) signaling","trans-Golgi Network Vesicle Budding","Phase I - Functionalization of compounds","Signaling by ERBB2","G2/M Checkpoints","ESR-mediated signaling","Telo
mere Maintenance","Costimulation by the CD28 family","Response to elevated platelet cytosolic Ca2+","Oxidative Stress Induced Senescence","SARS-CoV-1 Infection","G alpha (q) signalling events","Signal
ing by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) Cascade","RHO GTPases activate PAKs","Host Interactions of HIV factors","VEGFA-VEGFR2 Pathway","Transcriptional Regulation by TP53","APC/C-mediated de
gradation of cell cycle proteins","Parasite infection","Signaling by FLT3 ITD and TKD mutants","PI Metabolism","Activation of NMDA receptors and postsynaptic events","CaM pathway","Leishmania parasite
 growth and survival","G2/M Transition","G0 and Early G1","IGF1R signaling cascade","Glutamate binding","activation of AMPA receptors and synaptic plasticity","PTEN Regulation","Insulin receptor signa
lling cascade","Drug resistance of KIT mutants","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AKT network","Signaling by FGFR3 in disease","Semaphorin interactions","Interleukin
-2 family signaling","Drug resistance of PDGFR mutants","Toll Like Receptor 4 (TLR4) Cascade","Generation of second messenger molecules","Caspase activation via Dependence Receptors in the absence of 
ligand","Mitotic Metaphase and Anaphase","Transcriptional regulation by RUNX1","Signaling by RAS mutants",Mitophagy,"Toll Like Receptor 2 (TLR2) Cascade","G alpha (i) signalling events","EPH-Ephrin si
gnaling","HIV Life Cycle","Glycogen breakdown (glycogenolysis)","Signaling by FGFR2 in disease","Signaling by ROBO receptors","Loss of Function of SMAD2/3 in Cancer","HDR through Homologous Recombinat
ion (HRR) or Single Strand Annealing (SSA)","RAF/MAP kinase cascade","Apoptotic cleavage of cellular proteins","Antiviral mechanism by IFN-stimulated genes","Major pathway of rRNA processing in the nu
cleolus and cytosol","RHO GTPases activate PKNs","Sphingolipid de novo biosynthesis","G1 Phase","Signaling by AMER1 mutants","Pyruvate metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","S
ignaling by NOTCH1 HD+PEST Domain Mutants in Cancer","RHO GTPases activate CIT","G alpha (s) signalling events","p75NTR signals via NF-kB","Mitotic Prophase","RET signaling","Class A/1 (Rhodopsin-like
 receptors)","Signaling by NTRK3 (TRKC)","Interferon alpha/beta signaling","PTK6 promotes HIF1A stabilization","Role of phospholipids in phagocytosis","G alpha (z) signalling events","Signaling by FGF
R1 in disease","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","cGMP effects","Signaling by FGFR4","L1CAM interactions","Pervasive developmental disorders","PPARA 
activates gene expression","Transcriptional Regulation by VENTX","Cargo recognition for clathrin-mediated endocytosis","Constitutive Signaling by AKT1 E17K in Cancer","Interleukin-1 family signaling",
"Bile acid and bile salt metabolism","Ca2+ pathway","PTK6 Down-Regulation","NS1 Mediated Effects on Host Pathways","Cytosolic tRNA aminoacylation","FCERI mediated Ca+2 mobilization","Golgi Associated 
Vesicle Biogenesis","Ethanol oxidation","Downregulation of ERBB2 signaling","G2/M DNA damage checkpoint","Extra-nuclear estrogen signaling","FOXO-mediated transcription","Cytochrome P450 - arranged by
 substrate type","Extension of Telomeres","CD28 co-stimulation","G1/S Transition","Platelet degranulation","SARS-CoV-1 Genome Replication and Transcription","Gastrin-CREB signalling pathway via PKC an
d MAPK","Signalling to ERKs","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","VEGFR2 mediated cell proliferation","Regulation of TP53 Activ
ity","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Leishmania phagocytosis","STAT5 activation downstream of FLT3 ITD mutants","Synthesis of PIPs at the plasma membran
e","Post NMDA receptor activation events","Calmodulin induced events","Anti-inflammatory response favouring Leishmania parasite infection","Centrosome maturation","IRS-related events triggered by IGF1
R","Trafficking of AMPA receptors","Regulation of PTEN stability and activity","IRS-mediated signalling","Dasatinib-resistant KIT mutants","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"
PP2A and IER3 Regulate PI3K/AKT Signaling","Signaling by FGFR3 point mutants in cancer","Sema4D in semaphorin signaling","Interleukin-15 signaling","Imatinib-resistant PDGFR mutants","MyD88-independen
t TLR4 cascade","Mitotic Anaphase","RUNX1 regulates transcription of genes involved in BCR signaling","Signaling downstream of RAS mutants","Receptor Mediated Mitophagy","TP53 Regulates Transcription 
of DNA Repair Genes","Toll Like Receptor TLR6:TLR2 Cascade","Visual phototransduction","EPHA-mediated growth cone collapse","Late Phase of HIV Life Cycle","FGFR2 mutant receptor activation","Activatio
n of RAC1","Ephrin signaling","SMAD2/3 Phosphorylation Motif Mutants in Cancer","HDR through Homologous Recombination (HRR)","Negative regulation of MAPK pathway","ISG15 antiviral mechanism","Activate
d PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","RAS processing","Cyclin D associated events in G1","Truncations of AMER1 destabilize the destruction complex",
"Regulation of pyruvate dehydrogenase (PDH) complex","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Signalling to ERK5","p75NTR recruits signalling complexes","Nuclear Envelope Breakdown",
"Amine ligand-binding receptors","Activation of TRKA receptors","Activated NTRK3 signals through PI3K","Interleukin-2 signaling","Regulation of IFNA signaling","EPHB-mediated forward signaling","FGFR1
 mutant receptor activation","Downstream signaling of activated FGFR4","Recycling pathway of L1","Loss of function of MECP2 in Rett syndrome","Synthesis of PIPs at the Golgi membrane","Role of ABL in 
ROBO-SLIT signaling","Negative regulation of FGFR4 signaling","CRMPs in Sema3A signaling","Interleukin-1 signaling","Synthesis of bile acids and bile salts","Inhibition of PKR","SEMA3A-Plexin repulsio
n signaling by inhibiting Integrin adhesion","Assembly and cell surface presentation of NMDA receptors","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Estrogen-stimulated signaling 
through PRKCZ","FOXO-mediated transcription of oxidative stress","metabolic and neuronal genes","Endogenous sterols","Telomere Extension By Telomerase","CD28 dependent PI3K/Akt signaling","Cyclin E as
sociated events during G1/S transition","Replication of the SARS-CoV-1 genome","EGFR Transactivation by Gastrin","Prolonged ERK activation events","MAP kinase activation","Nef-mediates down modulation
 of cell surface receptors by recruiting them to clathrin adapters","Regulation of TP53 Expression and Degradation","APC/C:Cdc20 mediated degradation of mitotic proteins","FCGR3A-mediated phagocytosis
","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","PKA-mediated phosphorylation of CREB","ADORA2B mediated anti-inflammatory cytokines production","Loss of proteins 
required for interphase microtubule organization from the centrosome","Trafficking of GluR2-containing AMPA receptors","FCGR3A-mediated IL10 synthesis","PI3K Cascade","FGFR3 mutant receptor activation
","Regulation of TP53 Activity through Phosphorylation","Sema4D mediated inhibition of cell attachment and migration","TRIF(TICAM1)-mediated TLR4 signaling","Separation of Sister Chromatids","Sema4D i
nduced cell migration and growth-cone collapse","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","The phototransduction cascade","Signalling to RAS","Transcription of the HIV genome","Nef and s
ignal transduction","Activated point mutants of FGFR2","Activation of RAC1 downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","Negative feedback regulation of MAPK pathway","Regulation
 of TP53 Activity through Acetylation","Activation of AMPK downstream of NMDARs","Long-term potentiation","Activation of NIMA Kinases NEK9",NEK6,NEK7,"CD163 mediating an anti-inflammatory response","M
uscarinic acetylcholine receptors","NGF-independant TRKA activation","Depolymerisation of the Nuclear Lamina","Signaling by activated point mutants of FGFR1","FRS-mediated FGFR4 signaling","Loss of ph
osphorylation of MECP2 at T308","Spry regulation of FGF signaling","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","Signaling by cytosolic FGFR1 fusion mutants","Phosphorylation
 of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes","Frs2-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","Regula
tion of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","RSK activation","PKA activation","Loss of Nlp from mitotic centroso
mes","Signaling by activated point mutants of FGFR3","IKK complex recruitment mediated by RIP1",Inactivation,"recovery and regulation of the phototransduction cascade","p38MAPK events","HIV Transcript
ion Elongation","activated TAK1 mediates p38 MAPK activation","Ras activation upon Ca2+ influx through NMDA receptor","Presynaptic phase of homologous DNA pairing and strand exchange","JNK (c-Jun kina
ses) phosphorylation and  activation mediated by activated human TAK1","PI5P Regulates TP53 Acetylation","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Acti
vation of IRF3/IRF7 mediated by TBK1/IKK epsilon","PKB-mediated events","ERK/MAPK targets","CREB phosphorylation","APC-Cdc20 mediated degradation of Nek2A","Activation of the AP-1 family of transcript
ion factors","Tat-mediated elongation of the HIV-1 transcript","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","PDE3B signalling","ERKs are inactivated","Formation of HIV-1 elongation complex c
ontaining HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{staurosporine,Staurosporin,62996-74-1,62996741,(+)-Staurosporine,(+)Staurosporine,"Antibiotic 230","Antibiotic AM 2282",AM-2282,AM2282,"CCRIS 3272","Antibiotic AM-2282","Antibiotic AM2282",UNII-H88EP
A0A3N,UNIIH88EPA0A3N,"Alkaloid AM-2282 from Streptomyces","Alkaloid AM2282 from Streptomyces",H88EPA0A3N,CHEMBL388978,CHEBI:15738,GNF-PF-1389,GNFPF1389,meth,STAUROSPORINE}

> <pdid>
PD003511

> <targets>
{NULL,PKA,PKG,PKC}

> <classes>
{}

> <pubchem_cids>
{44259}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
    7.7858   -9.1806    0.0000 N   0  0
    6.3110   -8.9071    0.0000 C   0  0
    5.3370  -10.0479    0.0000 O   0  0
    5.8106   -7.4921    0.0000 C   0  0
    6.7829   -6.3499    0.0000 C   0  0
    6.2798   -4.9368    0.0000 C   0  0
    4.8092   -4.6676    0.0000 C   0  0
    3.8322   -5.8080    0.0000 C   0  0
    4.3352   -7.2212    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 O   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 12 19  2  0
 19 20  1  0
 20 10  2  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 24  1  0
 28 29  2  0
 29 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28536

> <plate>
Kinase v5-2

> <well>
K06

> <supplier_cmpd_name>
SB 431542

> <ctcr_id>
284

> <supplier_cmpd_id>
S1067

> <smiles>
NC(=O)c1ccc(cc1)c2[nH]c(c3ccccn3)c(n2)c4ccc5OCOc5c4

> <pd_targets>
{CYP1A2,TGFBR1,RIPK2,ALDH1A1,ACVR1B,CSNK1E,PRKD3,CYP2C19,IMPA1,CYP2D6,MAPK14,CYP3A4,CSNK1D,CSNK1A1L,MAPK1,KDM4E,LEF,MAPT,HPGD,HSD17B10,CSNK1A1,RPS6KA1,TGFBR2,ACVR1C}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Cytochrome P450",Kinase,Oxidoreductase,Hydrolase,Eraser,Protease,"Cytochrome P450 family 1","Protein Kinase","Cytochrome P450 family 2","Cytoc
hrome P450 family 3","Lysine demethylase","Metallo protease","Cytochrome P450 family 1A","TKL protein kinase group","CK1 protein kinase group","CAMK protein kinase group","Cytochrome P450 family 2C","
Cytochrome P450 family 2D","CMGC protein kinase group","Cytochrome P450 family 3A","Jumonji domain-containing","Metallo protease MAE clan","AGC protein kinase group","Cytochrome P450 1A1","TKL protein
 kinase STKR family","TKL protein kinase RIPK family","CK1 protein kinase CK1 family","CAMK protein kinase PKD family","Cytochrome P450 2C19","Cytochrome P450 2D6","CMGC protein kinase MAPK family","C
ytochrome P450 3A4","Metallo protease M34 family","AGC protein kinase RSK family","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase p38 subfamily","CK1 protein kinase CK1-a","CMGC protei
n kinase ERK1","AGC protein kinase RSK subfamily","TKL protein kinase STKR Type 2 subfamily","TKL protein kinase STKR1"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Catalytic receptors","Kinases (EC 2.7.x.x)","Inositol phosphate turnover","Chromatin modifying enzymes","Eicosanoid turnover","CYP1 family","Receptor kinases","CK
1: Casein kinase 1","CAMK: Calcium/calmodulin-dependent protein kinases","CYP2 family: drug metabolising subset","Inositol monophosphatase","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP3 family
","1.14.11.- Histone demethylases","Prostaglandin synthases","AGC: Containing PKA",PKG,"PKC families","TKL: Tyrosine kinase-like","Casein kinase 1 (CK1) family","Protein kinase D (PKD) family","Mitoge
n-activated protein kinases (MAP kinases)","RSK family","Receptor serine/threonine kinase (RSTK) family","Receptor interacting protein kinase (RIPK) family","p38 subfamily","ERK subfamily","RSK subfam
ily","Type I receptor serine/threonine kinases","Type II receptor serine/threonine kinases"}

> <pathway_reactome>
{Metabolism,Disease,"Immune System","Developmental Biology","Cell Cycle","Neuronal System","Biological oxidations","Diseases of signal transduction by growth factor receptors and second messengers","I
nnate Immune System","Signaling by NODAL",Mitotic,"Metabolism of lipids","Inositol phosphate metabolism","Infectious disease","Transmission across Chemical Synapses","Metabolism of amino acids and der
ivatives","Phase I - Functionalization of compounds","Signaling by TGF-beta Receptor Complex in Cancer","Toll-like Receptor Cascades","Regulation of signaling by NODAL","Mitotic G2-G2/M phases","Sphin
golipid metabolism","Synthesis of IP2",IP,"and Ins in the cytosol","Biosynthesis of specialized proresolving mediators (SPMs)","Uptake and actions of bacterial toxins","Neurotransmitter receptors and 
postsynaptic signal transmission","Branched-chain amino acid catabolism","Signaling by WNT in cancer","Cytochrome P450 - arranged by substrate type","Loss of Function of SMAD2/3 in Cancer","Toll Like 
Receptor 5 (TLR5) Cascade","Ethanol oxidation","G2/M Transition","Sphingolipid de novo biosynthesis","Biosynthesis of DHA-derived SPMs","Uptake and function of anthrax toxins","Activation of NMDA rece
ptors and postsynaptic events","Signaling by AMER1 mutants",Xenobiotics,"SMAD2/3 Phosphorylation Motif Mutants in Cancer","MyD88 cascade initiated on plasma membrane","Centrosome maturation","Biosynth
esis of maresins","Post NMDA receptor activation events","Biosynthesis of D-series resolvins","Truncations of AMER1 destabilize the destruction complex","Aromatic amines can be N-hydroxylated or N-dea
lkylated by CYP1A2","MAP kinase activation","Loss of proteins required for interphase microtubule organization from the centrosome","CYP2E1 reactions","Biosynthesis of maresin-like SPMs","Activation o
f AMPK downstream of NMDARs","activated TAK1 mediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family 
of transcription factors","ERK/MAPK targets","CREB phosphorylation","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{301836-41-9,301836419,SB-431542,SB431542,"SB 431542","4-(4-(benzo(d)(1,3)dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide","4(4(benzo(d)(1,3)dioxol5yl)5(pyridin2yl)1Himidazol2yl)benzamide",UN
II-E1557V1V0N,UNIIE1557V1V0N,"4-(4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL)BENZAMIDE","4(4(1,3BENZODIOXOL5YL)5(2PYRIDINYL)1HIMIDAZOL2YL)BENZAMIDE","SB 431542 hydrate",CHEMBL440084,T172
6,S1067,1614}

> <pdid>
PD003368

> <targets>
{TGF-beta,"TGF-beta Inhibitors",TGFbR1}

> <classes>
{}

> <pubchem_cids>
{4521392}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    5.1663  -10.5034    0.0000 C   0  0
    6.4691   -9.7600    0.0000 C   0  0
    7.7644  -10.5165    0.0000 C   0  0
    9.0672   -9.7731    0.0000 C   0  0
    9.0747   -8.2731    0.0000 C   0  0
   10.3776   -7.5297    0.0000 F   0  0
    7.7795   -7.5165    0.0000 C   0  0
    7.7840   -6.0157    0.0000 N   0  0
    6.4870   -5.2605    0.0000 C   0  0
    5.1855   -6.0062    0.0000 O   0  0
    6.4915   -3.7597    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 N   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6924   -4.0811    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    6.4767   -8.2600    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 18  1  0
 27 22  2  0
  7 28  2  0
 28  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28537

> <plate>
Kinase v5-2

> <well>
K08

> <supplier_cmpd_name>
ABT-869(Linifanib)

> <ctcr_id>
2503

> <supplier_cmpd_id>
S1003

> <smiles>
Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)c3cccc4[nH]nc(N)c34)c1

> <pd_targets>
{TEK,CSNK1G1,MAPK11,FLT1,PDGFRB,CDK19,CDK8,AKT1,FRK,NTRK2,CAMK2B,CDK11B,MUSK,DDR1,SRMS,EPHA6,AURKA,EPHA3,STK10,EPHB6,EPHB2,LATS2,MYLK2,ABL1,STK26,STK33,PLK4,EPHB3,KDR,FLT3,KIT,FLT4,RET,PDGFRA,BLK,MST1
R,TAOK1,HIPK4,MAP2K5,MKNK2,RPS6KA5,RIPK1,GAK,DDR2,CSF1R,EPHB4,MAPK9,MAPK14,MAPK15,FER,PRKG1,RPS6KA4,MAP4K3,MET,CSNK1D,STK3,PRKACA,TIE1,NTRK3,NTRK1,EGFR,CLK1,SRC,SGK3,AURKC,CAMK1,CDK13,LIMK2,HIPK3,LATS
1,STK32B,FGFR1,FGFR2,FGFR3,FGFR4,CDK1,SLK,TNIK,CDK11A,MARK2,LTK,CDK16,AURKB,MAP4K5,MERTK,MINK1,BMPR2,AXL,CDK9,MYO3B,ALK,CDC42BPG,CYP19A1,MKNK1,MAPK10,EPHA2,EPHA5,EPHA7,MAP4K1,STK4,INSR,IRAK4,PLK3,STK3
2A,CSNK2A1,RPS6KB1,TAOK3,LYN,CAMK2D,INSRR,MAPK13,MAP4K2,CDK7,CLK4,EPHB1,BRSK1,SRPK1,MAP3K19,ROCK2,PBK,DYRK3,CSNK1G2,CAMK2G,MAP2K2,PTK2,MAP3K20,SMO,BMPR1B,IRAK1,ROCK1,HIPK2,MELK,MAPK12,FES,P2RY14}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Membrane receptor",Kinase,"Cytochrome P450","Frizzled family G protein-coupled receptor","Family A G protein-coupled receptor","Protein Kinase","Cytochrome P450 family 
19","Smoothened receptor (frizzled family GPCR)","Small molecule receptor (family A GPCR)","TK protein kinase group","CK1 protein kinase group","CMGC protein kinase group","AGC protein kinase group","
CAMK protein kinase group","Other protein kinase group","STE protein kinase group","TKL protein kinase group","Cytochrome P450 family 19A","Nucleotide-like receptor (family A GPCR)","Tyrosine protein 
kinase Tie family","CK1 protein kinase CK1 family","CMGC protein kinase MAPK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","CMGC protein kinase CDK family","AGC
 protein kinase AKT family","Tyrosine protein kinase Src family","Tyrosine protein kinase Trk family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Musk family","Tyrosine protein kinase 
DDR family","Tyrosine protein kinase Eph family","Other protein kinase AUR family","STE protein kinase STE20 family","AGC protein kinase NDR family","CAMK protein kinase MLCK family","Tyrosine protein
 kinase Abl family","CAMK protein kinase unique family","Other protein kinase PLK family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Met family","CMGC protein kinase DYRK family","S
TE protein kinase STE7 family","CAMK protein kinase MAPKAPK family","AGC protein kinase RSK family","TKL protein kinase RIPK family","Other protein kinase NAK family","Tyrosine protein kinase Fer fami
ly","AGC protein kinase PKG family","AGC protein kinase PKA family","Tyrosine protein kinase EGFR family","CMGC protein kinase CLK family","AGC protein kinase SGK family","CAMK protein kinase CAMK1 fa
mily","TKL protein kinase LISK family","AGC protein kinase YANK family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase Alk family","Tyrosine protein kinase Axl family","TKL protein kin
ase STKR family","AGC protein kinase DMPK family","Cytochrome P450 19A1","Tyrosine protein kinase InsR family","TKL protein kinase IRAK family","Other protein kinase CK2 family","CMGC protein kinase S
RPK family","STE protein kinase STE11 family","Other protein kinase TOPK family","Tyrosine protein kinase Fak family","TKL protein kinase MLK family","Purine receptor","CMGC protein kinase p38 subfami
ly","CMGC protein kinase CDK8 subfamily","CMGC protein kinase PITSLRE subfamily","Tyrosine protein kinase Srm","STE protein kinase SLK subfamily","STE protein kinase YSK subfamily","STE protein kinase
 TAO subfamily","CMGC protein kinase HIPK subfamily","CAMK protein kinase MNK subfamily","AGC protein kinase MSK subfamily","CMGC protein kinase JNK subfamily","STE protein kinase KHS subfamily","STE 
protein kinase MST subfamily","TKL protein kinase LIMK subfamily","CMGC protein kinase CDC2 subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MARK subfamily","CMGC protein kinase TAIR
E subfamily","TKL protein kinase STKR Type 2 subfamily","CMGC protein kinase CDK9 subfamily","STE protein kinase NinaC subfamily","TKL protein kinase STKR Type 1 subfamily","AGC protein kinase GEK sub
family","AGC protein kinase p70 subfamily","CMGC protein kinase CDK7 subfamily","CAMK protein kinase BRSK subfamily","AGC protein kinase ROCK subfamily","CMGC protein kinase Dyrk2 subfamily","TKL prot
ein kinase MLK subfamily","CAMK protein kinase MELK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","G protein-coupled receptors","Receptor kinases","CK1: Casein kinase 1","CMGC: Containing CDK",MAPK,GSK3,"CLK families
","AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",CYP11,CYP17,CYP19,"CYP20 and CYP21 
families","Class Frizzled GPCRs","P2Y receptors","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","Cyclin-dependent kinase (CDK) family","Akt (Pro
tein kinase B","PKB) family","CAMK2 family","Other protein kinases","STE20 family","NDR family","Myosin Light Chain Kinase (MLCK) family","CAMK-unique family","Dual-specificity tyrosine-(Y)-phosphoryl
ation regulated kinase (DYRK) family","STE7 family","MAPK-Activated Protein Kinase (MAPKAPK) family","RSK family","TKL: Tyrosine kinase-like","Protein kinase G (PKG) family","Protein kinase A (PKA) fa
mily","CLK family","SGK family","CAMK1 family","YANK family","CAMK-like (CAMKL) family","DMPK family","SRPK family","Receptor tyrosine kinases (RTKs)","p38 subfamily","CDK8 subfamily","Non-receptor ty
rosine kinases (nRTKs)","PITSLRE subfamily","Aurora kinase (Aur) family","SLK subfamily","YSK subfamily","Polo-like kinase (PLK) family","TAO subfamily","HIPK subfamily","MKN subfamily","MSK subfamily
","Receptor interacting protein kinase (RIPK) family","Numb-associated kinase (NAK) family","JNK subfamily","Erk7 subfamily","KHS subfamily","MST subfamily","CRK7 subfamily","LIM domain kinase (LISK) 
family","CDK1 subfamily","MSN subfamily","MARK subfamily","TAIRE subfamily","Receptor serine/threonine kinase (RSTK) family","CDK9 subfamily","NinaC subfamily","GEK subfamily","Interleukin-1 receptor-
associated kinase (IRAK) family","Casein kinase 2 (CK2) family","p70 subfamily","CDK7 subfamily","BRSK subfamily","STE20 subfamily","Rho kinase","TOPK family","Dyrk2 subfamily","Mixed Lineage Kinase (
MLK) family","MELK subfamily","Type XII RTKs: TIE family of angiopoietin receptors","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 rece
ptor family","Src family","Type VII RTKs: Neurotrophin receptor/Trk family","Type IX RTKs: MuSK","Type XVI RTKs: DDR (collagen receptor) family","Type XIII RTKs: Ephrin receptor family","Abl family","
Type XIV RTKs: RET","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Fer family","Type I RTKs: ErbB (epidermal growth factor) receptor family","LIMK subfamily","Type XIX RTKs: Leukocyte 
tyrosine kinase (LTK) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type II receptor serine/threonine kinases","Type II RTKs: Insulin receptor family","Type V RTKs: 
FGF (fibroblast growth factor) receptor family","Fak family","MLK subfamily","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Metabolism,Disease,"Gene expression (Transcription)","Neuronal System","Cell Cycle","Extracellular matrix organization","Developmental Biology","Programmed Cell 
Death","Vesicle-mediated transport",Hemostasis,"Transport of small molecules","Cellular responses to external stimuli","Organelle biogenesis and maintenance","MAPK family signaling cascades","Innate I
mmune System","Signaling by Receptor Tyrosine Kinases","Intracellular signaling by second messengers","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second mess
engers","RNA Polymerase II Transcription","Transmission across Chemical Synapses",Mitotic,"ECM proteoglycans","Non-integrin membrane-ECM interactions","Signaling by Non-Receptor Tyrosine Kinases","Ner
vous system development","Signaling by Hippo","Infectious disease",Apoptosis,"Membrane Trafficking","Platelet homeostasis","Signaling by GPCR","Ion channel transport","Cellular responses to stress","C
ell surface interactions at the vascular wall","Signaling by TGFB family members","Biological oxidations","MTOR signalling","Cilium Assembly","MAPK1/MAPK3 signaling","Toll-like Receptor Cascades","Sig
naling by VEGF","PIP3 activates AKT signaling","Regulation of lipid metabolism by PPARalpha","Signaling by NOTCH1 in Cancer","Generic Transcription Pathway","Signaling by NTRKs","Neurotransmitter rece
ptors and postsynaptic signal transmission","Mitotic G2-G2/M phases","Signaling by PTK6","Axon guidance","Neutrophil degranulation","Leishmania infection","Apoptotic execution phase","Signaling by Ins
ulin receptor","Signaling by KIT in disease","Signaling by PDGFR in disease","Signaling by MST1","M Phase","trans-Golgi Network Vesicle Budding","Signaling by SCF-KIT","Nitric oxide stimulates guanyla
te cyclase","GPCR downstream signalling","Stimuli-sensing channels","Regulation of mitotic cell cycle","Cellular Senescence","Signaling by BMP","HIV Infection","Phase I - Functionalization of compound
s","Signaling by FGFR","Signaling by FGFR in disease","mTORC1-mediated signalling","Sphingolipid metabolism","Cargo trafficking to the periciliary membrane","GPCR ligand binding","RAF/MAP kinase casca
de","Toll Like Receptor 5 (TLR5) Cascade","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AKT network","PPARA activates gene expression","Signaling by NOTCH1 HD+PEST Domain Mutant
s in Cancer","Transcriptional Regulation by TP53","PTEN Regulation","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","G2/M Transition","PTK6 Down-Regulation","EPH-Eph
rin signaling","Parasite infection","Apoptotic cleavage of cellular proteins","VEGFA-VEGFR2 Pathway","Insulin receptor signalling cascade","Drug resistance of KIT mutants","RET signaling","Drug resist
ance of PDGFR mutants","Transcriptional regulation by RUNX1","Mitotic Metaphase and Anaphase","Toll Like Receptor 4 (TLR4) Cascade","Golgi Associated Vesicle Biogenesis","Transcriptional Regulation by
 VENTX","cGMP effects","L1CAM interactions","Semaphorin interactions","Signaling by NTRK3 (TRKC)","G alpha (q) signalling events","APC/C-mediated degradation of cell cycle proteins","Oxidative Stress 
Induced Senescence","HIV Life Cycle","Cytochrome P450 - arranged by substrate type","Signaling by FGFR4","Toll Like Receptor 2 (TLR2) Cascade","Signaling by FGFR1 in disease","Leishmania parasite grow
th and survival","Sphingolipid de novo biosynthesis","Signaling by FGFR3 in disease","BBSome-mediated cargo-targeting to cilium","Class A/1 (Rhodopsin-like receptors)","MyD88 cascade initiated on plas
ma membrane","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Regulation of TP53 Activ
ity","Regulation of PTEN stability and activity","Activation of TRKA receptors","Post NMDA receptor activation events","Centrosome maturation","EPHA-mediated growth cone collapse","EPHB-mediated forwa
rd signaling","Leishmania phagocytosis","VEGFR2 mediated cell proliferation","IRS-mediated signalling","Dasatinib-resistant KIT mutants","Imatinib-resistant PDGFR mutants","RUNX1 regulates transcripti
on of genes involved in BCR signaling","Mitotic Anaphase","Signalling to ERK5","MyD88-independent TLR4 cascade","Recycling pathway of L1","Sema4D in semaphorin signaling","Activated NTRK3 signals thro
ugh PI3K","Signalling to ERKs","Gastrin-CREB signalling pathway via PKC and MAPK","TP53 Regulates Transcription of DNA Repair Genes","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitoti
c proteins","Late Phase of HIV Life Cycle","Endogenous sterols","Negative regulation of FGFR4 signaling","Toll Like Receptor TLR6:TLR2 Cascade","FGFR1 mutant receptor activation","Anti-inflammatory re
sponse favouring Leishmania parasite infection","Signaling by FGFR3 point mutants in cancer","CRMPs in Sema3A signaling","Nucleotide-like (purinergic) receptors","MAP kinase activation","Regulation of
 TP53 Expression and Degradation","NGF-independant TRKA activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Recruitment of mitotic centrosome proteins and c
omplexes","Regulation of TP53 Activity through Phosphorylation","FCGR3A-mediated phagocytosis","Loss of proteins required for interphase microtubule organization from the centrosome","PI3K Cascade","S
eparation of Sister Chromatids","TRIF(TICAM1)-mediated TLR4 signaling","Sema4D mediated inhibition of cell attachment and migration","Prolonged ERK activation events","EGFR Transactivation by Gastrin"
,"Signalling to RAS","Activation of RAC1 downstream of NMDARs","Sema4D induced cell migration and growth-cone collapse","APC/C:Cdc20 mediated degradation of mitotic proteins","Transcription of the HIV
 genome","Spry regulation of FGF signaling","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Signaling by activated point mutants of FGFR1","FCGR3A-mediated IL10 synthesis","FGFR3 mutant recep
tor activation","P2Y receptors","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","Ras activation upon Ca2+ influx through NMDA receptor","Loss of Nlp from mitoti
c centrosomes","IKK complex recruitment mediated by RIP1","ARMS-mediated activation","p38MAPK events","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle chec
kpoint","HIV Transcription Elongation","Frs2-mediated activation","Signaling by activated point mutants of FGFR3","activated TAK1 mediates p38 MAPK activation","Activation of the AP-1 family of transc
ription factors","CREB phosphorylation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1
 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{BT869(LINIFANIB,Linifanib,796967-16-3,796967163,ABT-869,ABT869,"Linifanib (ABT-869)","Linifanib (ABT869)",1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea,1(4(3amino1Hindazol4yl)
phenyl)3(2fluoro5methylphenyl)urea,AL-39324,AL39324,"ABT 869",N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea,N(4(3amino1Hindazol4yl)phenyl)N'(2fluoro5methylphenyl)urea,UNII-CO9
3X137CW,UNIICO93X137CW,R,T2514,S1003,linifanib,ABT-869(Linifanib)}

> <pdid>
PD003290

> <targets>
{FLT-3,PDGFR,VEGFR,FLT3,Apoptosis,Autophagy,c-Fms,c-Kit}

> <classes>
{Apoptosis,Autophagy,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{11485656}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  1  0            999 V2000
   -0.3991  -13.3044    0.0000 C   0  0
    1.0960  -13.4245    0.0000 C   0  0
    1.9490  -12.1896    0.0000 N   0  0
    3.4443  -12.3076    0.0000 C   0  0
    4.2942  -11.0717    0.0000 C   0  0
    3.6488   -9.7176    0.0000 N   0  0
    2.1534   -9.5996    0.0000 C   0  0
    1.3035  -10.8356    0.0000 C   0  0
    4.4967   -8.4792    0.0000 C   0  0
    3.8490   -7.1253    0.0000 C   0  0
    4.6946   -5.8864    0.0000 C   0  0
    4.0445   -4.5346    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.7031   -5.6606    0.0000 C   0  0
    2.3532   -7.0124    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 N   0  0
   -3.8990   -0.7455    0.0000 C   0  0  2  0  0  0
   -3.8964    0.7545    0.0000 C   0  0
   -5.2003   -1.4932    0.0000 C   0  0
   -6.4994   -0.7433    0.0000 C   0  0
   -7.7985   -1.4932    0.0000 C   0  0
   -7.7985   -2.9932    0.0000 C   0  0
   -6.4995   -3.7433    0.0000 C   0  0
   -5.2004   -2.9933    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  6  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 13 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  1
 24 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
 22 32  2  0
 32 18  1  0
 32 33  1  0
 33 16  2  0
M  END
> <name>
UTKinase_V5

> <id>
28538

> <plate>
Kinase v5-2

> <well>
K10

> <supplier_cmpd_name>
AEE788

> <ctcr_id>
7140

> <supplier_cmpd_id>
S1486

> <smiles>
CCN1CCN(CC1)Cc2ccc(cc2)c3[nH]c4ncnc(N[C@H](C)c5ccccc5)c4c3

> <pd_targets>
{RET,EGFR,KDR,ERBB2,ERBB3,ERBB4,FLT1,YES1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Ret family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src
 family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type XIV RTKs: RET","Type I RTKs: ErbB (epidermal 
growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Src family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction","Neuronal System",Disease,"Nervous system development","Signaling by GPCR","Signaling by Receptor Tyrosine Kinases","Transmission across Chemical Synapse
s","Infectious disease","Axon guidance","GPCR downstream signalling","Signaling by VEGF","Neurotransmitter receptors and postsynaptic signal transmission","Leishmania infection","RET signaling","G alp
ha (q) signalling events","VEGFA-VEGFR2 Pathway","Activation of NMDA receptors and postsynaptic events","VEGF ligand-receptor interactions","Leishmania parasite growth and survival","Semaphorin intera
ctions","Gastrin-CREB signalling pathway via PKC and MAPK","VEGFR2 mediated cell proliferation","Post NMDA receptor activation events","VEGF binds to VEGFR leading to receptor dimerization","Anti-infl
ammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","EGFR Transactivation by Gastrin","Long-term potentiation","FCGR3A-mediated IL10 synthesis","Sema4D induced 
cell migration and growth-cone collapse"}

> <broad_targets>
{EGFR,ERBB2,ERBB4,FGFR2,FGFR3,KDR}

> <broad_moa>
{"EGFR inhibitor","VEGFR inhibitor"}

> <synonyms>
{"EE788 (NVPAEE788",497839-62-0,497839620,AEE788,AEE-788,"AEE 788",NVP-AEE788,NVPAEE788,"AEE788 (NVP-AEE788)","AEE788 (NVPAEE788)",UNII-F9JLR95I3I,UNIIF9JLR95I3I,GNF-Pf-5343,GNFPf5343,F9JLR95I3I,NVP-A
EE-788,C27H32N6,AEE,cc-434,cc434,MLS006011277,SCHEMBL613756,CHEMBL587723,GTPL7643,BDBM26105,CHEBI:40629,AEE788/,"AEE788; NVP-","AEE788; NVP",S1486}

> <pdid>
PD011169

> <targets>
{EGFR(HER),HER2,EGFR,Flt,VEGFR}

> <classes>
{}

> <pubchem_cids>
{10297043}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
   10.3996   -1.4837    0.0000 C   0  0
    9.0990   -0.7364    0.0000 N   0  0
    9.0964    0.7636    0.0000 C   0  0
    7.8003   -1.4887    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 O   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2982    3.7531    0.0000 N   0  0
    1.2960    5.2539    0.0000 C   0  0
    2.5925    6.0085    0.0000 C   0  0
    2.5873    7.5085    0.0000 C   0  0
    1.2856    8.2540    0.0000 C   0  0
    1.2804    9.7540    0.0000 F   0  0
   -0.0108    7.4995    0.0000 C   0  0
   -1.3124    8.2450    0.0000 Cl  0  0
   -0.0056    5.9995    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.4469   -5.2298    0.0000 C   0  0
   -2.9152   -5.5365    0.0000 C   0  0
   -3.6607   -4.2349    0.0000 O   0  0
   -2.6531   -3.1237    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  1  0
 20 22  2  0
 22 15  1  0
 13 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 12  1  0
 26 27  1  0
 27 28  2  0
 28 10  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28539

> <plate>
Kinase v5-2

> <well>
K12

> <supplier_cmpd_name>
BIBW2992(Tovok)

> <ctcr_id>
2843

> <supplier_cmpd_id>
S1011

> <smiles>
CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC4CCOC4

> <pd_targets>
{PHKG1,PHKG2,MAPK14,MAP2K5,TXK,EPHA6,BLK,MAPK9,DYRK2,EPHB6,ABL1,EGFR,ERBB2,STK10,FLT3,MET,AXL,CSNK1E,ERBB3,MAPK10,HIPK4,ERBB4,SLK,RPS6KA6,STK17A,GAK,SBK1,FRK,HCK,CIT,DYRK1A,DYRK1B,SRC,LCK,MKNK2,MKNK1,
IRAK1,RIPK2}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","CAMK protein kinase group","CMGC protein kinase group","STE protein kinase group","TK protein kinase group","CK1 protein kinase group","AGC prot
ein kinase group","Other protein kinase group","TKL protein kinase group","CAMK protein kinase PHk family","CMGC protein kinase MAPK family","STE protein kinase STE7 family","Tyrosine protein kinase T
ec family","Tyrosine protein kinase Eph family","Tyrosine protein kinase Src family","CMGC protein kinase DYRK family","Tyrosine protein kinase Abl family","Tyrosine protein kinase EGFR family","STE p
rotein kinase STE20 family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Met family","Tyrosine protein kinase Axl family","CK1 protein kinase CK1 family","AGC protein kinase RSK fam
ily","CAMK protein kinase DAPK family","Other protein kinase NAK family","Other protein kinase NKF1 family","AGC protein kinase DMPK family","CAMK protein kinase MAPKAPK family","TKL protein kinase IR
AK family","TKL protein kinase RIPK family","CMGC protein kinase p38 subfamily","CMGC protein kinase JNK subfamily","CMGC protein kinase Dyrk2 subfamily","STE protein kinase SLK subfamily","CMGC prote
in kinase HIPK subfamily","AGC protein kinase RSK subfamily","AGC protein kinase CRIK subfamily","CMGC protein kinase Dyrk1 subfamily","CAMK protein kinase MNK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7",
"Sterile 11","Sterile 20 kinases","Receptor kinases","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","Phosphorylase kinase (PHK) family","Mitogen-activated protein kinases (MAP kinases
)","STE7 family","TK: Tyrosine kinase","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","STE20 family","Casein kinase 1 (CK1) family","RSK family","Death-associated kinas
e (DAPK) family","Other protein kinases","DMPK family","MAPK-Activated Protein Kinase (MAPKAPK) family","TKL: Tyrosine kinase-like","p38 subfamily","Non-receptor tyrosine kinases (nRTKs)","Receptor ty
rosine kinases (RTKs)","JNK subfamily","Dyrk2 subfamily","SLK subfamily","HIPK subfamily","RSK subfamily","Numb-associated kinase (NAK) family","NKF1 family","Other DMPK family kinases","Dyrk1 subfami
ly","MKN subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","Receptor interacting protein kinase (RIPK) family","Tec family","Type XIII RTKs: Ephrin receptor family","Src family","Abl
 family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XI RTK
s: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{Metabolism,"Immune System","Signal Transduction","Developmental Biology","Gene expression (Transcription)",Disease,"Cell Cycle","Neuronal System","Vesicle-mediated transport","Metabolism of carbohydr
ates","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Nervous system development","RNA Polymerase II Transcription","Infectious disease","Signaling by GPCR",Mitotic,"Intracellular sig
naling by second messengers","Transmission across Chemical Synapses","Membrane Trafficking","Signaling by Rho GTPases","Glycogen metabolism","Toll-like Receptor Cascades","Signaling by NTRKs","Fc epsi
lon receptor (FCERI) signaling","Axon guidance","Generic Transcription Pathway","Leishmania infection","GPCR downstream signalling","Neutrophil degranulation","Signaling by Insulin receptor","Signalin
g by VEGF","Mitotic G2-G2/M phases","PIP3 activates AKT signaling","Neurotransmitter receptors and postsynaptic signal transmission","trans-Golgi Network Vesicle Budding","HIV Infection","RHO GTPase E
ffectors","Mitotic G1 phase and G1/S transition","Signaling by FGFR","Glycogen breakdown (glycogenolysis)","Toll Like Receptor 5 (TLR5) Cascade","Signaling by NTRK1 (TRKA)","FCERI mediated Ca+2 mobili
zation","EPH-Ephrin signaling","Transcriptional regulation by RUNX1","Transcriptional Regulation by TP53","Parasite infection","G alpha (q) signalling events","Semaphorin interactions","Insulin recept
or signalling cascade","VEGFA-VEGFR2 Pathway","G2/M Transition","Negative regulation of the PI3K/AKT network","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biogenesi
s","PTEN Regulation","Host Interactions of HIV factors","RHO GTPases activate CIT","G0 and Early G1","Signaling by FGFR4","MyD88 cascade initiated on plasma membrane","Signalling to ERK5","EPHA-mediat
ed growth cone collapse","RUNX1 regulates transcription of genes involved in BCR signaling","Regulation of TP53 Activity","EPHB-mediated forward signaling","Leishmania phagocytosis","Gastrin-CREB sign
alling pathway via PKC and MAPK","Sema4D in semaphorin signaling","IRS-mediated signalling","Centrosome maturation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Post NMDA receptor activation even
ts","Regulation of PTEN stability and activity","The role of Nef in HIV-1 replication and disease pathogenesis","Signalling to ERKs","Negative regulation of FGFR4 signaling","MAP kinase activation","R
egulation of TP53 Activity through Phosphorylation","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone collapse","PI3K Cascade","Sema4D med
iated inhibition of cell attachment and migration","Loss of proteins required for interphase microtubule organization from the centrosome","CREB1 phosphorylation through NMDA receptor-mediated activat
ion of RAS signaling","Nef and signal transduction","Signalling to RAS","Long-term potentiation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Spry 
regulation of FGF signaling","MAPK targets/ Nuclear events mediated by MAP kinases","Loss of Nlp from mitotic centrosomes","RSK activation","p38MAPK events","Nef Mediated CD4 Down-regulation","activat
ed TAK1 mediates p38 MAPK activation","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{EGFR,ERBB2,ERBB4}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{Afatinib-d6,Afatinibd6,MFCD12407405,"Tovok, Afatinib","Afatinib E-Isomer","Afatinib EIsomer","Afatinib Impurity D","Afatinib Impurity 3",CHEMBL2132902,HMS3244L04,HMS3244L08,HMS3244L12,HMS3295G11,HMS3
651A03,1313874-96-2,1313874962,1680184-59-1,1680184591,AKOS026750415,AK-43479,AK43479,SY028094,SY047,S1011,BIBW2992(Tovok),"Afatinib (BIBW2992)"}

> <pdid>
PD003240

> <targets>
{EGFR(HER),HER2,EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{53445376}

$$$$
UTKinase_V5
  SciTegic11012413002D

 62 66  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -2.5998    3.0004    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   11.5957   -1.5000    0.0000 C   0  0
   10.2966   -0.7500    0.0000 C   0  0
   10.2966    0.7500    0.0000 C   0  0
    8.9976    1.5000    0.0000 C   0  0
    7.6985    0.7500    0.0000 C   0  0
    7.6985   -0.7500    0.0000 C   0  0
    8.9976   -1.5000    0.0000 C   0  0
    6.3988    1.5004    0.0000 S   0  0
    5.1000    0.7500    0.0000 O   0  0
    6.3978    3.0004    0.0000 O   0  0
    5.0994    2.2498    0.0000 O   0  0
   38.9032    2.6332    0.0000 C   0  0
   38.2885    1.2649    0.0000 S   0  0
   39.1665    0.0487    0.0000 O   0  0
   39.7808    1.4169    0.0000 O   0  0
   36.7953    1.1135    0.0000 C   0  0
   35.9168    2.3304    0.0000 C   0  0
   34.4237    2.1789    0.0000 N   0  0
   33.5452    3.3958    0.0000 C   0  0
   32.0546    3.2447    0.0000 C   0  0
   31.0526    4.3610    0.0000 O   0  0
   29.7002    3.7421    0.0000 C   0  0
   29.8358    2.2610    0.0000 C   0  0
   31.3025    1.9468    0.0000 C   0  0
   28.4006    4.4925    0.0000 C   0  0
   28.4005    5.9925    0.0000 C   0  0
   27.1015    6.7425    0.0000 C   0  0
   25.8025    5.9924    0.0000 C   0  0
   24.5034    6.7424    0.0000 N   0  0
   23.2044    5.9924    0.0000 C   0  0
   23.2044    4.4924    0.0000 N   0  0
   24.5034    3.7424    0.0000 C   0  0
   24.5004    2.2416    0.0000 N   0  0
   23.1995    1.4930    0.0000 C   0  0
   23.1943   -0.0070    0.0000 C   0  0
   21.8927   -0.7525    0.0000 C   0  0
   20.5962    0.0020    0.0000 C   0  0
   19.2954   -0.7466    0.0000 O   0  0
   19.2924   -2.2474    0.0000 C   0  0
   17.9916   -2.9960    0.0000 C   0  0
   17.9863   -4.4961    0.0000 C   0  0
   16.6847   -5.2416    0.0000 C   0  0
   15.3883   -4.4871    0.0000 C   0  0
   15.3934   -2.9872    0.0000 C   0  0
   14.0970   -2.2327    0.0000 F   0  0
   16.6950   -2.2416    0.0000 C   0  0
   20.6014    1.5020    0.0000 C   0  0
   19.3050    2.2565    0.0000 Cl  0  0
   21.9030    2.2475    0.0000 C   0  0
   25.8025    4.4924    0.0000 C   0  0
   27.1015    3.7424    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  8 10  2  0
  8 11  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 16 19  1  0
 19 20  1  0
 19 21  2  0
 19 22  2  0
 23 24  1  0
 24 25  2  0
 24 26  2  0
 24 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 31  2  0
 33 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 39 40  1  0
 40 41  2  0
 41 42  1  0
 42 43  2  0
 43 44  1  0
 44 45  1  0
 45 46  2  0
 46 47  1  0
 47 48  2  0
 48 49  1  0
 49 50  1  0
 50 51  1  0
 51 52  2  0
 52 53  1  0
 53 54  2  0
 54 55  1  0
 55 56  1  0
 55 57  2  0
 57 51  1  0
 48 58  1  0
 58 59  1  0
 58 60  2  0
 60 45  1  0
 43 61  1  0
 61 39  1  0
 61 62  2  0
 62 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28540

> <plate>
Kinase v5-2

> <well>
K14

> <supplier_cmpd_name>
Lapatinib Ditosylate

> <ctcr_id>
2541

> <supplier_cmpd_id>
S1028

> <smiles>
Cc1ccc(cc1)[S](O)(=O)=O.Cc2ccc(cc2)[S](O)(=O)=O.C[S](=O)(=O)CCNCc3oc(cc3)c4ccc5ncnc(Nc6ccc(OCc7cccc(F)c7)c(Cl)c6)c5c4

> <pd_targets>
{AURKB,RET,ERBB2,EGFR,ABL1,ABCB11,PDGFRB,ERBB3,KCNH2,CYP3A5,CDK2,INSR,PIK3C2B,TUBA1A,SLK,KMT2A,MEN1,PI4KB,MAP2K5,STK10,MAP2K7,RIPK2,CYP3A4,PIK3C2G,ERBB4}

> <pathway_gtopdb>
{Enzyme,Transporter,"Ion channel","Structural protein","Epigenetic regulator",Kinase,"Primary active transporter","Voltage-gated ion channel","Cytochrome P450",Transferase,Reader,"Protein Kinase","ATP
-binding cassette","Potassium channels","Cytochrome P450 family 3",Bromodomain,"Other protein kinase group","TK protein kinase group","ABCB subfamily","Voltage-gated potassium channel","Cytochrome P45
0 family 3A","CMGC protein kinase group","STE protein kinase group","TKL protein kinase group","Other protein kinase AUR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase EGFR fami
ly","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR family","Cytochrome P450 3A5","CMGC protein kinase CDK family","Tyrosine protein kinase InsR family","STE protein kinase STE20 f
amily","STE protein kinase STE7 family","TKL protein kinase RIPK family","Cytochrome P450 3A4","CMGC protein kinase CDC2 subfamily","STE protein kinase SLK subfamily"}

> <pathway_chembl>
{Receptors,Transporters,"Ion channels",Enzymes,"Other protein targets","Catalytic receptors","ATP-binding cassette transporter family","Voltage-gated ion channels","Cytochrome P450","Kinases (EC 2.7.x
.x)",Tubulins,"Receptor kinases","ABCB subfamily","Potassium channels","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Lipid modifying kinases","STE: Homologs of yeast Sterile 7","Steri
le 11","Sterile 20 kinases","Other protein kinases","TK: Tyrosine kinase","Voltage-gated potassium channels","Cyclin-dependent kinase (CDK) family","Phosphatidylinositol-4-phosphate 3-kinase family","
STE20 family","1-phosphatidylinositol 4-kinase family","STE7 family","TKL: Tyrosine kinase-like","Aurora kinase (Aur) family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)"
,"CDK1 subfamily","SLK subfamily","Receptor interacting protein kinase (RIPK) family","Type XIV RTKs: RET","Type I RTKs: ErbB (epidermal growth factor) receptor family","Abl family","Type III RTKs: PD
GFR",CSFR,Kit,"FLT3 receptor family","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Cell Cycle","Developmental Biology","Signal Transduction",Disease,Metabolism,"Muscle contraction","Gene expression (Transcription)","Immune System","Neuronal System",Mitotic,"Nervous system developm
ent","Signaling by GPCR","Infectious disease","Metabolism of lipids","Intracellular signaling by second messengers","Cardiac conduction","Biological oxidations","RNA Polymerase II Transcription","Sign
aling by Receptor Tyrosine Kinases","Innate Immune System","Transmission across Chemical Synapses","M Phase","Axon guidance","GPCR downstream signalling","Leishmania infection","Metabolism of steroids
","PIP3 activates AKT signaling","Phase 3 - rapid repolarisation","Phase I - Functionalization of compounds","Generic Transcription Pathway","Phospholipid metabolism","Mitotic G2-G2/M phases","Signali
ng by NTRKs","Neutrophil degranulation","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotransmitter receptors and postsynaptic signal transmission","Mit
otic Metaphase and Anaphase","RET signaling","Semaphorin interactions","G alpha (q) signalling events","Parasite infection","Bile acid and bile salt metabolism","Negative regulation of the PI3K/AKT ne
twork","Cytochrome P450 - arranged by substrate type","Transcriptional Regulation by TP53","PI Metabolism","G2/M Transition","Signaling by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) Cascade","Biosynth
esis of DHA-derived SPMs","Activation of NMDA receptors and postsynaptic events","Mitotic Anaphase","Sema4D in semaphorin signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Leishmania phag
ocytosis","Synthesis of bile acids and bile salts",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling",Xenobiotics,"Regulation of TP53 Activity","Synthesis of PIPs at the plasma membrane","Centrosome mat
uration","Synthesis of PIPs at the Golgi membrane","Signalling to ERK5","MyD88 cascade initiated on plasma membrane","Biosynthesis of maresins","Post NMDA receptor activation events","Separation of Si
ster Chromatids","Sema4D induced cell migration and growth-cone collapse","EGFR Transactivation by Gastrin","FCGR3A-mediated phagocytosis","Synthesis of bile acids and bile salts via 7alpha-hydroxycho
lesterol","Regulation of TP53 Expression and Degradation","Loss of proteins required for interphase microtubule organization from the centrosome","MAP kinase activation","Biosynthesis of maresin-like 
SPMs","Long-term potentiation","Regulation of TP53 Degradation","Loss of Nlp from mitotic centrosomes","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","activated
 TAK1 mediates p38 MAPK activation"}

> <broad_targets>
{EGFR,ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{"Lapatinib Ditosylate",388082-77-7,388082777,Tykerb,Tyverb,"Lapatinib (GW-572016) Ditosylate","Lapatinib (GW572016) Ditosylate","Lapatinib (ditosylate)",388082-78-8,388082788,UNII-4WK72K94MC,UNII4WK7
2K94MC,4WK72K94MC,"388082-77-7 (ditosylate)","388082777 (ditosylate)","Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016)","Lapatinib Ditosylate (Tykerb, Tyverb, GW572016)",Tyker,T6235,T0078L,S1028,"Lap
atinib ditosylate monohydrate",lapatinib}

> <pdid>
PD003505

> <targets>
{EGFR(HER),HER2,EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{9941095}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
    4.2146   -6.5095    0.0000 N   0  0
    3.3372   -5.2929    0.0000 C   0  0
    3.8056   -3.8679    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 N   0  0
   -2.5998    3.0004    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
    1.3786   -3.8595    0.0000 N   0  0
    1.8372   -5.2877    0.0000 N   0  0
    0.9498   -6.4949    0.0000 C   0  0
    1.5527   -7.8684    0.0000 O   0  0
   -0.5420   -6.3307    0.0000 C   0  0
   -1.4322   -7.5380    0.0000 C   0  0
   -0.8317   -8.9126    0.0000 F   0  0
   -2.9229   -7.3709    0.0000 C   0  0
   -3.5234   -5.9963    0.0000 C   0  0
   -2.6333   -4.7890    0.0000 C   0  0
   -1.1427   -4.9561    0.0000 C   0  0
   -0.2526   -3.7487    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  1  0
 12 14  2  0
 12 15  2  0
  4 16  2  0
 16 17  1  0
 17  2  1  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 20  1  0
 26 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28541

> <plate>
Kinase v5-2

> <well>
K16

> <supplier_cmpd_name>
JNJ-7706621

> <ctcr_id>
6196

> <supplier_cmpd_id>
S1249

> <smiles>
Nc1nc(Nc2ccc(cc2)[S](N)(=O)=O)nn1C(=O)c3c(F)cccc3F

> <pd_targets>
{STK26,MAP4K2,RIOK1,ALK,MYLK,RIOK3,SRPK1,ACVR1,CLK3,BRSK1,BRSK2,CSNK1G1,PAK4,PLK1,KIT,JAK2,JAK3,CLK1,TYK2,FLT3,FLT4,CSNK1G2,MARK3,MAP2K1,MAP2K2,ABL1,AURKA,CCNB1,CCNB2,CCNB3,CDK1,MAPK1,MAPK3,KDR,RET,FG
FR1,ROCK1,AURKB,DMPK,TEC,STK16,PRKCD,JAK1,TLK1,CDK16,PDGFRA,PDGFRB,MARK4,TNK1,MET,CLK4,EPHA7,MAPK7,PRKD3,CDK7,STK4,MAP4K1,TEK,MAPK10,SIK1,DCLK3,MAPK6,GSK3B,NUAK1,FGFR3,MARK2,MARK1,MAP2K4,CSF1R,TESK1,F
LT1,MAPK15,BMP2K,MERTK,STK3,TIE1,TNNI3K,CDK5,MAPK8,FGFR2,SYK,DCLK2,MAPK4,NUAK2,AAK1,PRKAA2,CDK2,TTK,LIMK1,MELK,GAK,ACVRL1,LIMK2,CDK18,TLK2,MAP2K3,PRKAA1,CCND1,CDK4,CSNK1D,MAP3K9,ACVR2A,COQ8A,PAK5,PDPK
1,EIF2AK2,RPS6KA1,RPS6KA3,RPS6KA4,PIP4K2B,PKN2,ACVR2B,BMX,MAP2K6,RPS6KA2,AXL,MAP4K5,CLK2,CDK9,RIPK1,PLK3,ANKK1,CAMKK1,CAMKK2,CSNK1E,PRKCQ,STK25,IKBKE,STK10,PRKD1,CDK11A,BMPR2,SLK,DCLK1,GSK3A,CSNK2A2,S
IK2,CCNA1,CCNA2,ROS1,MST1R,PIP5K1A,PAK6,PAK3,CDK17,CSNK1G3,TYRO3,EIF2AK4,CDK11B,CDK3,MAP3K12,CDK14,STK17A,LRRK2,ROCK2,AURKC,DAPK3,EPHA6,PLK4,FGR,CSNK1A1,IRAK3,LCK,STK24,NTRK2,GRK5,TAOK1,MAP4K3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","Atypical protein kinase group","TKL protein kinase group","CAMK protein kinase group","CMGC protein kinase group","CK1 protein kinase group"
,"Other protein kinase group","TK protein kinase group","AGC protein kinase group","STE protein kinase STE20 family","Atypical protein kinase RIO family","TKL protein kinase STKR family","CAMK protein
 kinase MLCK family","CMGC protein kinase SRPK family","CMGC protein kinase CLK family","CAMK protein kinase CAMK1 family","CK1 protein kinase CK1 family","Other protein kinase PLK family","Tyrosine p
rotein kinase PDGFR family","Tyrosine protein kinase JakA family","Tyrosine protein kinase VEGFR family","STE protein kinase STE7 family","Tyrosine protein kinase Abl family","Other protein kinase AUR
 family","CMGC protein kinase CDK family","CMGC protein kinase MAPK family","Tyrosine protein kinase Ret family","Tyrosine protein kinase FGFR family","AGC protein kinase DMPK family","Tyrosine protei
n kinase Tec family","Other protein kinase NAK family","AGC protein kinase PKC family","Other protein kinase TLK family","Tyrosine protein kinase Ack family","Tyrosine protein kinase Met family","Tyro
sine protein kinase Eph family","CAMK protein kinase PKD family","Tyrosine protein kinase Tie family","CAMK protein kinase DCAMK1 family","CMGC protein kinase GSK family","TKL protein kinase LISK fami
ly","Tyrosine protein kinase Axl family","TKL protein kinase MLK family","Tyrosine protein kinase Syk family","Other protein kinase TTK family","AGC protein kinase PDK1 subfamily","Other protein kinas
e PEK family","AGC protein kinase RSK family","AGC protein kinase PKN family","TKL protein kinase RIPK family","Other protein kinase CAMKK family","Other protein kinase CK2 family","Tyrosine protein k
inase Sev family","CAMK protein kinase DAPK family","TKL protein kinase LRRK family","Tyrosine protein kinase Src family","TKL protein kinase IRAK family","Tyrosine protein kinase Trk family","AGC pro
tein kinase GRK family","STE protein kinase YSK subfamily","STE protein kinase KHS subfamily","Atypical protein kinase RIO1 subfamily","TKL protein kinase STKR Type 1 subfamily","Atypical protein kina
se RIO3 subfamily","TKL protein kinase STKR1","CAMK protein kinase BRSK subfamily","STE protein kinase PAKB subfamily","CAMK protein kinase MARK subfamily","CMGC protein kinase CDC2 subfamily","CMGC p
rotein kinase ERK1","AGC protein kinase ROCK subfamily","AGC protein kinase GEK subfamily","AGC protein kinase PKC delta subfamily","CMGC protein kinase TAIRE subfamily","CMGC protein kinase ERK5","CM
GC protein kinase CDK7 subfamily","STE protein kinase MST subfamily","CMGC protein kinase JNK subfamily","CAMK protein kinase QIK subfamily","CMGC protein kinase ERK3","CAMK protein kinase NuaK subfam
ily","TKL protein kinase TESK subfamily","TKL protein kinase HH498 subfamily","CMGC protein kinase CDK5 subfamily","CAMK protein kinase AMPK subfamily","TKL protein kinase LIMK subfamily","CAMK protei
n kinase MELK subfamily","CMGC protein kinase PCTAIRE","TKL protein kinase MLK subfamily","TKL protein kinase STKR Type 2 subfamily","Other protein kinase PKR","AGC protein kinase RSK subfamily","AGC 
protein kinase MSK subfamily","CMGC protein kinase CDK9 subfamily","Other protein kinase Meta subfamily","STE protein kinase SLK subfamily","CMGC protein kinase PITSLRE subfamily","STE protein kinase 
PAKA subfamily","CK1 protein kinase CK1-g","Other protein kinase GCN2 subfamily","CMGC protein kinase PFTAIRE","AGC protein kinase GRK subfamily","STE protein kinase TAO subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Atypical,"Receptor kinases","CAMK: Calcium/calmodulin-dependent pro
tein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","Lipid modifying kinases","STE20 family","RIO family","TK: Tyrosine kinase
","Myosin Light Chain Kinase (MLCK) family","SRPK family","TKL: Tyrosine kinase-like","CLK family","CAMK-like (CAMKL) family","Casein kinase 1 (CK1) family","Other protein kinases","STE7 family","DMPK
 family","Protein kinase C (PKC) family","Cyclin-dependent kinase (CDK) family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase D (PKD) family","DCAMKL family","Glycogen synthase kin
ase (GSK) family","ABC1 family","PDK1 family","RSK family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Protein kinase N (PKN) family","Type I PIP kinases (1-phosphatidy
linositol-4-phosphate 5-kinase family)","Death-associated kinase (DAPK) family","G protein-coupled receptor kinases (GRKs)","YSK subfamily","KHS subfamily","RIO1 subfamily","Receptor tyrosine kinases 
(RTKs)","RIO3 subfamily","Receptor serine/threonine kinase (RSTK) family","BRSK subfamily","PAKB subfamily","Polo-like kinase (PLK) family","Non-receptor tyrosine kinases (nRTKs)","MARK subfamily","Au
rora kinase (Aur) family","Rho kinase","GEK subfamily","NAK family","Delta subfamily","Tousled-like kinase (TLK) family","TAIRE subfamily","ERK subfamily","CDK7 subfamily","MST subfamily","JNK subfami
ly","QIK subfamily","GSK subfamily","NuaK subfamily","LIM domain kinase (LISK) family","Erk7 subfamily","Numb-associated kinase (NAK) family","Mixed Lineage Kinase (MLK) family","CDK5 subfamily","AMPK
 subfamily","CDK1 subfamily","TTK family","MELK subfamily","ABC1-B subfamily","PEK family","RSK subfamily","MSK subfamily","CDK9 subfamily","Receptor interacting protein kinase (RIPK) family","CAMKK f
amily","IKK family","SLK subfamily","PITSLRE subfamily","Casein kinase 2 (CK2) family","PAKA subfamily","Leucine-rich repeat kinase (LRRK) family","Interleukin-1 receptor-associated kinase (IRAK) fami
ly","GRK4 subfamily","TAO subfamily","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type I receptor serine/threonine kinases","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family",
"Janus kinase (JakA) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Abl family","Type XIV RTKs: RET","Type V RTKs: FGF (fibroblast growth factor) receptor family","
Tec family","Ack family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIII RTKs: Ephrin receptor family","Type XII RTKs: TIE family of angiopoietin receptors","TESK subfamily","
Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","HH498 subfamily","Syk family","LIMK subfamily","MLK subfamily","Type II receptor serine/threonine kinases","Other PEK family kinases","Me
ta subfamily","Type XVII RTKs: ROS receptors","GCN2 subfamily","LZK subfamily","Src family","Type VII RTKs: Neurotrophin receptor/Trk family"}

> <pathway_reactome>
{"Programmed Cell Death","Metabolism of RNA","Signal Transduction","Developmental Biology","Cell Cycle",Disease,"Immune System",Metabolism,"Gene expression (Transcription)","Muscle contraction","Organ
elle biogenesis and maintenance","Circadian Clock","Cell-Cell communication",Hemostasis,"Vesicle-mediated transport","Neuronal System","Cellular responses to external stimuli",Apoptosis,"rRNA processi
ng","Signaling by Rho GTPases","Nervous system development",Mitotic,"Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Immune system","Signaling 
by Receptor Tyrosine Kinases","Metabolism of lipids","Infectious disease","RNA Polymerase II Transcription","Cardiac conduction","Intracellular signaling by second messengers","Cilium Assembly","Innat
e Immune System","Signaling by Hippo","MAPK family signaling cascades","Cell junction organization","Cell surface interactions at the vascular wall","Membrane Trafficking","Signaling by TGFB family me
mbers","Signaling by NODAL","Transmission across Chemical Synapses","Signaling by GPCR","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases","Apoptotic execution phase","rRNA pr
ocessing in the nucleus and cytosol","RHO GTPase Effectors","Axon guidance","Mitotic G2-G2/M phases","Signaling by KIT in disease","Mitotic G1 phase and G1/S transition","Signaling by Interleukins","I
nterferon Signaling","Signaling by Insulin receptor","Signaling by VEGF","Sphingolipid metabolism","Oncogenic MAPK signaling","Signaling by NTRKs","Leishmania infection","Generic Transcription Pathway
","Signaling by FGFR in disease","M Phase","Ion homeostasis","DAG and IP3 signaling","Signaling by PDGFR in disease","PIP3 activates AKT signaling","Anchoring of the basal body to the plasma membrane"
,"Toll-like Receptor Cascades","HIV Infection","MAPK1/MAPK3 signaling","MAPK6/MAPK4 signaling","SARS-CoV Infections","Cell-extracellular matrix interactions","Clathrin-mediated endocytosis","Regulatio
n of mitotic cell cycle","trans-Golgi Network Vesicle Budding","Signaling by BMP","Regulation of signaling by NODAL","Influenza Infection","Phospholipid metabolism","Neurotransmitter receptors and pos
tsynaptic signal transmission","GPCR downstream signalling","Neutrophil degranulation","Signaling by MST1","Response of EIF2AK4 (GCN2) to amino acid deficiency","Signaling by PTK6","Caspase activation
 via extrinsic apoptotic signalling pathway","Apoptotic cleavage of cellular proteins","Major pathway of rRNA processing in the nucleolus and cytosol","RHO GTPases activate PAKs","Signaling by ROBO re
ceptors","G2/M Transition","Drug resistance of KIT mutants","G1 Phase","Interleukin-2 family signaling","Interferon alpha/beta signaling","Insulin receptor signalling cascade","VEGF ligand-receptor in
teractions","Sphingolipid de novo biosynthesis","Signaling by RAS mutants","Signaling by NTRK1 (TRKA)","Parasite infection","Transcriptional Regulation by TP53","VEGFA-VEGFR2 Pathway","RET signaling",
"Signaling by FGFR1 in disease","Semaphorin interactions","Mitotic Metaphase and Anaphase",Interleukin-3,"Interleukin-5 and GM-CSF signaling","CaM pathway","Antiviral mechanism by IFN-stimulated genes
","Drug resistance of PDGFR mutants","Negative regulation of the PI3K/AKT network","EPH-Ephrin signaling","Toll Like Receptor 5 (TLR5) Cascade","HIV Life Cycle","RAF/MAP kinase cascade","SARS-CoV-1 In
fection","Signaling by FGFR3 in disease","Transcriptional Regulation by VENTX","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Signaling by FGFR2 in disease","Lei
shmania parasite growth and survival","Cargo recognition for clathrin-mediated endocytosis","APC/C-mediated degradation of cell cycle proteins","Golgi Associated Vesicle Biogenesis","NS1 Mediated Effe
cts on Host Pathways","L1CAM interactions","RHO GTPases activate PKNs","PI Metabolism","Toll Like Receptor 4 (TLR4) Cascade","Activation of NMDA receptors and postsynaptic events","G alpha (i) signall
ing events","PTK6 promotes HIF1A stabilization","Caspase activation via Dependence Receptors in the absence of ligand","Toll Like Receptor 2 (TLR2) Cascade","Host Interactions of HIV factors","G alpha
 (q) signalling events","Activation of RAC1","Centrosome maturation","Dasatinib-resistant KIT mutants","Cyclin D associated events in G1","Interleukin-15 signaling","Regulation of IFNA signaling","IRS
-mediated signalling","VEGF binds to VEGFR leading to receptor dimerization","Signaling downstream of RAS mutants","Signalling to ERKs","Leishmania phagocytosis","Regulation of TP53 Activity","VEGFR2 
mediated cell proliferation","FGFR1 mutant receptor activation","Sema4D in semaphorin signaling","Mitotic Anaphase","Calmodulin induced events","ISG15 antiviral mechanism","Imatinib-resistant PDGFR mu
tants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","EPHA-mediated growth cone collapse","MyD88 cascade initiated on plasma membrane","Late Phase of HIV Life Cycle","SARS-CoV-1 Genome Replication 
and Transcription","Signaling by FGFR3 point mutants in cancer","FGFR2 mutant receptor activation","Anti-inflammatory response favouring Leishmania parasite infection","Activation of APC/C and APC/C:C
dc20 mediated degradation of mitotic proteins","Inhibition of PKR","Recycling pathway of L1","Synthesis of PIPs at the plasma membrane","MyD88-independent TLR4 cascade","Post NMDA receptor activation 
events","Visual phototransduction","Ephrin signaling","Toll Like Receptor TLR6:TLR2 Cascade","The role of Nef in HIV-1 replication and disease pathogenesis","Activation of TRKA receptors","Loss of pro
teins required for interphase microtubule organization from the centrosome","PI3K Cascade","Prolonged ERK activation events","FCGR3A-mediated phagocytosis","Regulation of TP53 Activity through Phospho
rylation","Signaling by activated point mutants of FGFR1","Sema4D induced cell migration and growth-cone collapse","Separation of Sister Chromatids","Sema4D mediated inhibition of cell attachment and 
migration","MAP kinase activation","Transcription of the HIV genome","Replication of the SARS-CoV-1 genome","FGFR3 mutant receptor activation","Activated point mutants of FGFR2","FCGR3A-mediated IL10 
synthesis","Regulation of TP53 Expression and Degradation","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Acetylation","TRIF(TICAM1)-mediated TLR4 signalin
g","Activation of RAC1 downstream of NMDARs","Activation of AMPK downstream of NMDARs","The phototransduction cascade","Recruitment of mitotic centrosome proteins and complexes","MyD88:MAL(TIRAP) casc
ade initiated on plasma membrane","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","NGF-independant TRKA activation","Loss of Nlp from mitotic centrosom
es","Frs2-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","HIV Transcription Elongation","Signaling by activated point mutants of FGFR3","JNK (c-Jun kinases) phosphorylatio
n and  activation mediated by activated human TAK1","Regulation of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","activate
d TAK1 mediates p38 MAPK activation","PI5P Regulates TP53 Acetylation","IKK complex recruitment mediated by RIP1",Inactivation,"recovery and regulation of the phototransduction cascade","Activation of
 IRF3/IRF7 mediated by TBK1/IKK epsilon","Nef Mediated CD4 Down-regulation","ERK/MAPK targets","Tat-mediated elongation of the HIV-1 transcript","Activation of the AP-1 family of transcription factors
","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","CREB phosphorylation","ERKs are inactivated","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{AURKA,AURKB,CDK1,CDK2}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{JNJ-7706621,JNJ7706621,443797-96-4,443797964,UNII-74GK72DON8,UNII74GK72DON8,RWJ-387252,RWJ387252,74GK72DON8,CHEMBL191003,"JNJ 7706621","Aurora Kinase/Cdk Inhibitor",3ama,SKE,JNJ-770662,JNJ770662,Kino
me_3748,Kinome3748,Kinome-3748,"Kinome 3748",PubChem22455,cc-474,cc474,MLS006011037,BDBM6866,GTPL5932,SCHEMBL1060773,C15H12F2N6O3S,CHEBI:9,T6126,S1249}

> <pdid>
PD011042

> <targets>
{"Aurora / CDK",CDK,"Aurora Kinase"}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{5330790}

$$$$
UTKinase_V5
  SciTegic11012413002D

 69 72  0  0  0  0            999 V2000
    1.9161   10.5654    0.0000 C   0  0
    3.3245   10.0492    0.0000 O   0  0
    3.5827    8.5707    0.0000 C   0  0
    2.4301    7.6108    0.0000 C   0  0
    2.6850    6.1326    0.0000 C   0  0
    4.0927    5.6144    0.0000 C   0  0
    5.2453    6.5743    0.0000 C   0  0
    4.9903    8.0525    0.0000 C   0  0
    6.1455    9.0106    0.0000 O   0  0
    7.5532    8.4901    0.0000 P   0  0
    7.8057    7.0115    0.0000 C   0  0
    8.9599    7.9692    0.0000 C   0  0
    8.7078    9.4476    0.0000 O   0  0
    1.5337    5.1698    0.0000 C   0  0
    1.7909    3.6911    0.0000 C   0  0
    3.1995    3.1753    0.0000 C   0  0
    0.6400    2.7300    0.0000 C   0  0
    0.8000    1.1200    0.0000 C   0  0
    2.0600    0.3500    0.0000 C   0  0
    1.8870   -1.1400    0.0000 O   0  0
    3.4300    0.8000    0.0000 C   0  0
    3.8662    2.2352    0.0000 C   0  0
    4.3600   -0.3900    0.0000 C   0  0
    5.8000   -0.4000    0.0000 C   0  0
    6.6151    0.8592    0.0000 C   0  0
    6.4400   -1.8000    0.0000 C   0  0
    7.9345   -1.9281    0.0000 O   0  0
    5.5100   -3.1600    0.0000 C   0  0
    4.0188   -3.2852    0.0000 O   0  0
    3.3799   -4.6424    0.0000 C   0  0
    6.5100   -4.2800    0.0000 C   0  0
    7.9504   -3.8613    0.0000 O   0  0
    6.2500   -5.8600    0.0000 C   0  0
    7.5042   -6.6827    0.0000 C   0  0
    4.8700   -6.7500    0.0000 C   0  0
    3.3400   -6.2300    0.0000 C   0  0
    2.3025   -7.3134    0.0000 C   0  0
    2.7800   -4.7900    0.0000 C   0  0
    1.1200   -4.8600    0.0000 C   0  0
    0.1200   -3.6900    0.0000 C   0  0
   -1.4100   -4.1500    0.0000 C   0  0
   -2.6300   -3.1700    0.0000 C   0  0
   -4.1200   -3.7800    0.0000 C   0  0
   -4.3154   -5.2672    0.0000 C   0  0
   -5.3700   -2.8300    0.0000 C   0  0
   -6.8600   -3.4400    0.0000 C   0  0
   -7.8600   -2.2400    0.0000 C   0  0
   -9.2500   -2.5000    0.0000 C   0  0
  -10.1800   -1.4400    0.0000 C   0  0
   -9.7100    0.0100    0.0000 C   0  0
  -10.7377    1.1027    0.0000 C   0  0
   -8.0800    0.4300    0.0000 C   0  0
   -8.4778    1.8763    0.0000 O   0  0
   -7.2300   -0.9300    0.0000 O   0  0
   -6.6100    0.8600    0.0000 C   0  0
   -5.5855   -0.2356    0.0000 O   0  0
   -6.1000    2.2500    0.0000 C   0  0
   -7.0129    3.4402    0.0000 O   0  0
   -4.5400    2.3900    0.0000 N   0  0
   -5.4800    3.8300    0.0000 C   0  0
   -4.8400    5.2900    0.0000 C   0  0
   -3.4600    5.5000    0.0000 C   0  0
   -2.6400    4.4900    0.0000 C   0  0
   -3.1200    3.1200    0.0000 C   0  0
   -1.9000    2.2900    0.0000 C   0  0
   -1.8545    0.7907    0.0000 O   0  0
   -0.7100    3.2100    0.0000 O   0  0
   -5.1674   -1.3437    0.0000 O   0  0
   -6.3526   -0.4242    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
 10 13  2  0
  5 14  1  0
 14 15  1  0
 15 16  1  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 21 23  1  0
 23 24  2  3
 24 25  1  0
 24 26  1  0
 26 27  1  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 28 31  1  0
 31 32  2  0
 31 33  1  0
 33 34  1  0
 33 35  1  0
 35 36  1  0
 36 37  1  0
 36 38  1  0
 38 39  2  3
 39 40  1  0
 40 41  2  3
 41 42  1  0
 42 43  2  3
 43 44  1  0
 43 45  1  0
 45 46  1  0
 46 47  1  0
 47 48  1  0
 48 49  1  0
 49 50  1  0
 50 51  1  0
 50 52  1  0
 52 53  1  0
 52 54  1  0
 54 47  1  0
 52 55  1  0
 55 56  2  0
 55 57  1  0
 57 58  2  0
 57 59  1  0
 59 60  1  0
 60 61  1  0
 61 62  1  0
 62 63  1  0
 63 64  1  0
 64 59  1  0
 64 65  1  0
 65 66  2  0
 65 67  1  0
 67 17  1  0
 45 68  1  0
 68 69  1  0
M  END
> <name>
UTKinase_V5

> <id>
28542

> <plate>
Kinase v5-2

> <well>
K18

> <supplier_cmpd_name>
Deforolimus(MK-8669)

> <ctcr_id>
3035

> <supplier_cmpd_id>
S1022

> <smiles>
COC1CC(CCC1O[P](C)(C)=O)CC(C)C2CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C(C)C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC

> <pd_targets>
{MTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by TP53","Regulation of TP53 Activity","Regulation of TP53 Expression a
nd Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{EFOROLIMUS(MK8669,Ridaforolimus,572924-54-0,572924540,FT-0674424,FT0674424,S1022,Deforolimus(MK-8669),"Ridaforolimus (Deforolimus, MK-8669)"}

> <pdid>
PD012223

> <targets>
{mTOR,Autophagy}

> <classes>
{PI3K/Akt/mTOR,Autophagy}

> <pubchem_cids>
{71433797}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 41  0  0  0  0            999 V2000
    3.1882    2.6402    0.0000 C   0  0
    2.7248    1.2135    0.0000 N   0  0
    3.6065    0.0000    0.0000 C   0  0
    5.1065    0.0000    0.0000 O   0  0
    2.7248   -1.2135    0.0000 N   0  0
    3.1884   -2.6409    0.0000 C   0  0
    4.6235   -3.0601    0.0000 C   0  0
    4.9782   -4.5176    0.0000 C   0  0
    3.8933   -5.5535    0.0000 C   0  0
    2.4538   -5.1320    0.0000 C   0  0
    2.0991   -3.6745    0.0000 C   0  0
    4.2482   -7.0118    0.0000 C   0  0
    3.1630   -8.0473    0.0000 C   0  0
    4.6022   -8.4694    0.0000 C   0  0
    5.6883   -7.4345    0.0000 C   0  0
    7.1276   -7.8569    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 C   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 N   0  0
   -1.2942   -8.2509    0.0000 C   0  0
   -1.2919   -9.7509    0.0000 C   0  0
    0.0084  -10.4988    0.0000 C   0  0
    1.3062   -9.7467    0.0000 C   0  0
    1.3038   -8.2467    0.0000 C   0  0
    0.0036   -7.4988    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  1  0
 12 14  1  0
 12 15  1  0
 15 16  3  0
  5 17  1  0
 17 18  2  0
 18  2  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 17  1  0
 26 21  1  0
 24 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 30  1  0
 35 36  2  0
 36 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28543

> <plate>
Kinase v5-2

> <well>
K20

> <supplier_cmpd_name>
BEZ235

> <ctcr_id>
1084

> <supplier_cmpd_id>
S1009

> <smiles>
CN1C(=O)N(c2ccc(cc2)C(C)(C)C#N)c3c1cnc4ccc(cc34)c5cnc6ccccc6c5

> <pd_targets>
{ATR,CHEK1,PIK3CG,PIK3CD,PIK3CB,MTOR,PIK3R5,PIK3R1,PIK3CA,MAP4K2,LTK,JAK3,ALK,CSF1R,CLK4,PIK3C2B,PIK3C3,AURKB,ATM,PIK3C2A,LIMK1,LRRK2,NEK2,MLST8,RPTOR,CDK7,ACVR1,MET,MAP4K5,ABCB11,PIK3R2,PIK3R3}

> <pathway_gtopdb>
{Enzyme,Transporter,Kinase,Transferase,"Primary active transporter","Protein Kinase","ATP-binding cassette","Atypical protein kinase group","CAMK protein kinase group","STE protein kinase group","TK p
rotein kinase group","TKL protein kinase group","CMGC protein kinase group","Other protein kinase group","ABCB subfamily","Atypical protein kinase PIKK family","CAMK protein kinase CAMK1 family","STE 
protein kinase STE20 family","Tyrosine protein kinase Alk family","Tyrosine protein kinase JakA family","TKL protein kinase STKR family","Tyrosine protein kinase PDGFR family","CMGC protein kinase CLK
 family","Other protein kinase AUR family","TKL protein kinase LISK family","TKL protein kinase LRRK family","Other protein kinase NEK family","CMGC protein kinase CDK family","Tyrosine protein kinase
 Met family","CAMK protein kinase CHK1 subfamily","Atypical protein kinase FRAP subfamily","STE protein kinase KHS subfamily","TKL protein kinase STKR Type 1 subfamily","TKL protein kinase LIMK subfam
ily","CMGC protein kinase CDK7 subfamily","TKL protein kinase STKR1"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Kinases (EC 2.7.x.x)","Catalytic receptors","ATP-binding cassette transporter family",Atypical,"CAMK: Calcium/calmodulin-dependent protein kinases","Lipid modifying ki
nases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","ABCB subfamily","Phosphatidyl inositol 3' kinase-related
 kinases (PIKK) family","CAMK-like (CAMKL) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","STE20 family","TK: Tyrosine kinase","CLK family","Phosphatidylinositol-4-phosphate 3-kinase 
family","Phosphatidylinositol 3-kinase family","Other protein kinases","TKL: Tyrosine kinase-like","Cyclin-dependent kinase (CDK) family","ATR subfamily","CHK1 subfamily","FRAP subfamily","KHS subfami
ly","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Aurora kinase (Aur) family","Other PIKK family kinases","LIM domain kinase (LISK) family","Leucine-rich repeat kinase (L
RRK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","CDK7 subfamily","Receptor serine/threonine kinase (RSTK) family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor fa
mily","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","LIMK subfamily","Type I receptor serine/threonine kinases","Type X RTKs: HGF (hepatocyte growth factor) recep
tor family"}

> <pathway_reactome>
{"DNA Repair",Metabolism,"Immune System","Signal Transduction","Gene expression (Transcription)",Disease,"Cell Cycle","Developmental Biology","DNA Double-Strand Break Repair","Metabolism of lipids","C
ytokine Signaling in Immune system","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers",Mitoti
c,"Cell Cycle Checkpoints","Nervous system development","Signaling by Non-Receptor Tyrosine Kinases","Infectious disease","Homology Directed Repair","Phospholipid metabolism","Signaling by Interleukin
s","Signaling by Insulin receptor","Generic Transcription Pathway","Signaling by FGFR in disease","M Phase","G1/S DNA Damage Checkpoints","Axon guidance","Signaling by PTK6","Regulation of mitotic cel
l cycle","HIV Infection","Metabolism of steroids","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","PI Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insu
lin receptor signalling cascade","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","Interleukin-2 family signaling","Transcriptional Regulation by VENTX","Mitotic Metaphase and Anap
hase","p53-Dependent G1/S DNA damage checkpoint","Semaphorin interactions","PTK6 promotes HIF1A stabilization","APC/C-mediated degradation of cell cycle proteins","HIV Life Cycle","Bile acid and bile 
salt metabolism","HDR through Homologous Recombination (HRR)","Synthesis of PIPs at the plasma membrane","Interleukin receptor SHC signaling","IRS-mediated signalling","Regulation of TP53 Activity","F
GFR1 mutant receptor activation","Interleukin-15 signaling","Mitotic Anaphase","p53-Dependent G1 DNA Damage Response","Synthesis of PIPs at the early endosome membrane","Sema4D in semaphorin signaling
","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Late Phase of HIV Life Cycle","Synthesis of bile acids and bile salts","Homologous DNA Pairing and Strand Exchange","P
I3K Cascade","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","Separation of Sister Chromatids","Stabilization of p53","Sema4D induced cell migration and g
rowth-cone collapse","APC/C:Cdc20 mediated degradation of mitotic proteins","Transcription of the HIV genome","Sema4D mediated inhibition of cell attachment and migration","Synthesis of bile acids and
 bile salts via 7alpha-hydroxycholesterol","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation","Autodegradation of the E3 ubiquitin ligase COP1","APC:Cdc
20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","HIV Transcription Elongation","APC-Cdc20 mediated degradation of Nek2A","Tat-mediated elongation of t
he HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{ATR,MTOR,PIK3CA,PIK3CD,PIK3CG}

> <broad_moa>
{"mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{dactolisib,915019-65-7,915019657,NVP-BEZ235,NVPBEZ235,BEZ235,"NVP-BEZ 235","NVPBEZ 235",BEZ-235,"BEZ 235","NVP BEZ235","BEZ235 (NVP-BEZ235)","BEZ235 (NVPBEZ235)",NVP-BEZ-235,UNII-RUJ6Z9Y0DT,UNIIRUJ6Z
9Y0DT,"BEZ235 (NVP-BEZ235, Dactolisib)","BEZ235 (NVPBEZ235, Dactolisib)",RUJ6Z9Y0DT,CHEBI:71952,BEZ235(NVP-BEZ235),BEZ235(NVPBEZ235),"915019-65-7 (free base)","915019657 (free base)",T2235,S1009,Dacto
lisib}

> <pdid>
PD003533

> <targets>
{mTOR,"PI3K MTOR",Autophagy,PI3K}

> <classes>
{Autophagy,PI3K/Akt/mTOR}

> <pubchem_cids>
{11977753}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    0.9513   -6.4982    0.0000 O   0  0
    1.8372   -5.2877    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    3.8056   -3.8679    0.0000 C   0  0
    5.2311   -3.4009    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.3786   -3.8595    0.0000 S   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0008    0.0000 C   0  0
   -3.8959   -3.7529    0.0000 C   0  0
   -3.8935   -5.2529    0.0000 C   0  0
   -2.5933   -6.0009    0.0000 N   0  0
   -1.2954   -5.2488    0.0000 C   0  0
   -1.2978   -3.7488    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  2  1  0
  6  8  2  3
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 16 23  1  0
 23 12  1  0
 23 24  2  0
 24  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28544

> <plate>
Kinase v5-2

> <well>
K22

> <supplier_cmpd_name>
GSK1059615

> <ctcr_id>
1948

> <supplier_cmpd_id>
S1360

> <smiles>
O=C1NC(=O)C(S1)=Cc2ccc3nccc(c4ccncc4)c3c2

> <pd_targets>
{PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIK3R1,PIK3R2,PIK3R3,PIK3R5}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by FGFR in disease","Signaling by FGFR1 in disease","FGFR1 mutant receptor activation","Signaling
 by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
{PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{"PI3K inhibitor GS1059615",HMS3295M21,HMS3654N17,BCP02498,AKOS026750445,NCGC00346509-01,NCGC0034650901,FT-0669060,FT0669060,T2357,S1360,GSK-1059615,GSK1059615}

> <pdid>
PD003556

> <targets>
{mTOR,PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{71317162}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  0  0            999 V2000
    4.4186   -7.3727    0.0000 C   0  0
    2.9357   -7.1465    0.0000 N   0  0
    1.9983   -8.3186    0.0000 C   0  0
    2.5437   -9.7168    0.0000 C   0  0
    1.6085  -10.8896    0.0000 C   0  0
    2.1565  -12.2859    0.0000 O   0  0
    3.6397  -12.5095    0.0000 C   0  0
    4.5750  -11.3368    0.0000 C   0  0
    4.0270   -9.9405    0.0000 O   0  0
    2.3903   -5.7483    0.0000 S   0  0
    1.8445   -4.3511    0.0000 O   0  0
    0.9074   -5.5222    0.0000 O   0  0
    3.3277   -4.5763    0.0000 N   0  0
    2.7822   -3.1780    0.0000 C   0  0
    3.7175   -2.0053    0.0000 C   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.4523    2.0983    0.0000 N   0  0
   -3.8856    1.6561    0.0000 C   0  0
   -4.2194    0.1937    0.0000 C   0  0
   -3.1198   -0.8265    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.4008   -2.9088    0.0000 O   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 C   0  0
   -5.6535   -0.2486    0.0000 C   0  0
   -6.8343    0.6557    0.0000 C   0  0
   -8.0595   -0.2097    0.0000 N   0  0
   -7.6150   -1.6424    0.0000 N   0  0
   -8.5129   -2.8440    0.0000 C   0  0
   -6.1152   -1.6624    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  2 10  1  0
 10 11  2  0
 10 12  2  0
 10 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 17  1  0
 28 29  2  0
 29 14  1  0
 23 30  1  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  1  0
 33 35  1  0
 35 30  2  0
M  END
> <name>
UTKinase_V5

> <id>
28545

> <plate>
Kinase v5-2

> <well>
M04

> <supplier_cmpd_name>
MK-2461

> <ctcr_id>
2842

> <supplier_cmpd_id>
S2774

> <smiles>
CN(CC1COCCO1)[S](=O)(=O)Nc2ccc3C=Cc4ncc(cc4C(=O)c3c2)c5cnn(C)c5

> <pd_targets>
{MET,FLT1,NTRK1,NTRK2,FLT4,AURKA,PDGFRB,MERTK,FGFR2,KDR,FLT3,FGFR1,CYP2C9,MST1R,RET,FGFR3,CYP3A4,ABL1,JAK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 2","Cytochrome P450 family 3","TK protein kinase group","Other protein kinase group","Cytochrome P450 family 2C","Cytochrome P
450 family 3A","Tyrosine protein kinase Met family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Trk family","Other protein kinase AUR family","Tyrosine protein kinase PDGFR family"
,"Tyrosine protein kinase Axl family","Tyrosine protein kinase FGFR family","Cytochrome P450 2C9","Tyrosine protein kinase Ret family","Cytochrome P450 3A4","Tyrosine protein kinase Abl family","Tyros
ine protein kinase JakA family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Cytochrome P450","Receptor kinases","CYP2 family: drug metabolising subset","CYP3 family","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kin
ases (RTKs)","Aurora kinase (Aur) family","Non-receptor tyrosine kinases (nRTKs)","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor)
 receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type V RTKs: 
FGF (fibroblast growth factor) receptor family","Type XIV RTKs: RET","Abl family","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction","Gene expression (Transcription)",Hemostasis,Disease,Metabolism,"Cell Cycle","Nervous system development","Signaling by Receptor Tyrosine Kinases","RNA P
olymerase II Transcription","Intracellular signaling by second messengers","Cell surface interactions at the vascular wall","Diseases of signal transduction by growth factor receptors and second messe
ngers","Biological oxidations","Metabolism of lipids","Infectious disease",Mitotic,"Axon guidance","Signaling by VEGF","Signaling by NTRKs","Generic Transcription Pathway","PIP3 activates AKT signalin
g","Signaling by FGFR in disease","Signaling by Insulin receptor","Phase I - Functionalization of compounds","Signaling by MST1","Biosynthesis of specialized proresolving mediators (SPMs)","Leishmania
 infection","Mitotic G1 phase and G1/S transition","Semaphorin interactions","VEGF ligand-receptor interactions","Signaling by NTRK1 (TRKA)","Transcriptional Regulation by TP53","Negative regulation o
f the PI3K/AKT network","Signaling by FGFR2 in disease","VEGFA-VEGFR2 Pathway","Insulin receptor signalling cascade","Signaling by FGFR1 in disease","Cytochrome P450 - arranged by substrate type","RET
 signaling","Signaling by FGFR3 in disease","Biosynthesis of DHA-derived SPMs","Parasite infection","G1 Phase","Sema4D in semaphorin signaling","VEGF binds to VEGFR leading to receptor dimerization","
Signalling to ERKs","Activation of TRKA receptors","Regulation of TP53 Activity",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","FGFR2 mutant receptor activation","VEGFR2 mediated cell proliferation
","IRS-mediated signalling","FGFR1 mutant receptor activation",Xenobiotics,"Signaling by FGFR3 point mutants in cancer","Biosynthesis of maresins","Leishmania phagocytosis","Cyclin D associated events
 in G1","Sema4D mediated inhibition of cell attachment and migration","Prolonged ERK activation events","NGF-independant TRKA activation","Regulation of TP53 Activity through Phosphorylation","Activat
ed point mutants of FGFR2","PI3K Cascade","Signaling by activated point mutants of FGFR1","CYP2E1 reactions","FGFR3 mutant receptor activation","Biosynthesis of maresin-like SPMs","FCGR3A-mediated pha
gocytosis","ARMS-mediated activation","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
{FGFR1,FGFR2,FGFR3,FLT1,FLT3,FLT4,KDR,MERTK,MET,MST1R,NTRK1,NTRK2,PDGFRB}

> <broad_moa>
{"FGFR inhibitor","VEGFR inhibitor"}

> <synonyms>
{MK2461,SCHEMBL2326906,HMS3651N11,BCP09219,NCGC00389216-01,NCGC0038921601,AK251218,T6094,S2774,MK-2461}

> <pdid>
PD010580

> <targets>
{c-Met,FGFR,PDGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{15981080}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 41  0  0  0  0            999 V2000
    6.4971   -0.7566    0.0000 F   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    3.8919   -5.2525    0.0000 F   0  0
    5.1945   -3.0045    0.0000 C   0  0
    6.4946   -3.7543    0.0000 C   0  0
    7.7945   -3.0041    0.0000 N   0  0
    9.0950   -3.7516    0.0000 C   0  0
   10.3927   -2.9992    0.0000 C   0  0
   10.3899   -1.4992    0.0000 O   0  0
    9.0894   -0.7517    0.0000 C   0  0
    7.7918   -1.5041    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 C   0  0
   -2.5112   -6.1125    0.0000 C   0  0
   -2.0454   -7.5384    0.0000 N   0  0
   -0.5454   -7.5360    0.0000 N   0  0
   -0.0841   -6.1087    0.0000 C   0  0
    0.3387   -8.7487    0.0000 C   0  0
   -0.1635  -10.1569    0.0000 C   0  0
    0.8088  -11.2991    0.0000 C   0  0
    2.2841  -11.0281    0.0000 N   0  0
    2.7871   -9.6150    0.0000 C   0  0
    1.8148   -8.4728    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 10  1  0
  4 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 16  1  0
 25 20  1  0
 23 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  1  0
 30 26  2  0
 29 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28546

> <plate>
Kinase v5-2

> <well>
M06

> <supplier_cmpd_name>
NVP-BSK805

> <ctcr_id>
8280

> <supplier_cmpd_id>
S2686

> <smiles>
Fc1cc(cc(F)c1CN2CCOCC2)c3cccc4ncc(nc34)c5cnn(c5)C6CCNCC6

> <pd_targets>
{JAK3,JAK1,JAK2,TYK2,ABL1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase JakA family","Tyrosine protein kinase Abl family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Janus kinase (JakA) family","Abl family"}

> <pathway_reactome>
{"Immune System","Cell Cycle",Disease,"Cytokine Signaling in Immune system",Mitotic,"Infectious disease","Signaling by Interleukins","Interferon Signaling","Mitotic G1 phase and G1/S transition","Leis
hmania infection","Interleukin-2 family signaling","Antiviral mechanism by IFN-stimulated genes","G1 Phase","Interferon alpha/beta signaling","Parasite infection","Interleukin-15 signaling","ISG15 ant
iviral mechanism","Cyclin D associated events in G1","Regulation of IFNA signaling","Leishmania phagocytosis","FCGR3A-mediated phagocytosis"}

> <broad_targets>
{JAK2}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{VPBSK80,NVP-BSK805,NVPBSK805,1092499-93-8,1092499938,CHEMBL1092926,"BSK 805",DQX,"NVP-BSK 805 HCl","NVPBSK 805 HCl",C27H30Cl2F2N6O,"NVP-BSK 805","NVPBSK 805",SCHEMBL2800994,EX-A286,EXA286,BCP29570,BD
BM50315231,MFCD22419018,ZINC49070412,CS-1629,CS1629,NCGC00263202-01,NCGC0026320201,NCGC00263202-08,NCGC0026320208,AC-28460,AC28460,AK473881,HY-14722,HY14722,X7514,Q,T5049,T6294,HY-14722,"NVP-BSK805 2H
Cl (1092499-93-8(free base))",NVP-BSK805,"NVP BSK 805"}

> <pdid>
PD003577

> <targets>
{JAK}

> <classes>
{}

> <pubchem_cids>
{46398810}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    8.8671    7.0482    0.0000 N   0  0
    7.4093    6.6952    0.0000 C   0  0
    6.9849    5.2556    0.0000 C   0  0
    8.0193    4.1692    0.0000 O   0  0
    5.5263    4.9023    0.0000 N   0  0
    5.1019    3.4627    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    4.2568    0.5878    0.0000 C   0  0
    5.7171    0.9385    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    3.9511   -0.8815    0.0000 N   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -5.1962    3.0000    0.0000 C   0  0
   -3.8971    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    4.8082   -4.6653    0.0000 C   0  0
    6.2996   -4.8254    0.0000 F   0  0
    3.9242   -5.8772    0.0000 F   0  0
    5.4155   -6.0369    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 12  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 20  1  0
 29 24  1  0
 21 30  2  0
 30 17  1  0
 14 31  1  0
 31 32  1  0
 31 33  1  0
 31 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28547

> <plate>
Kinase v5-2

> <well>
M08

> <supplier_cmpd_name>
OSU-03012

> <ctcr_id>
5641

> <supplier_cmpd_id>
S1106

> <smiles>
NCC(=O)Nc1ccc(cc1)n2nc(cc2c3ccc4c(ccc5ccccc45)c3)C(F)(F)F

> <pd_targets>
{PDPK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase PDK1 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","PDK1 family"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by TP53","Regulation of TP53 Activity","Regulation of TP53 Expression a
nd Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{PDPK1}

> <broad_moa>
{"phosphoinositide dependent kinase inhibitor"}

> <synonyms>
{"SU03012 (AR12",OSU-03012,OSU03012,742112-33-0,742112330,AR-12,AR12,"OSU 03012","OSU-03012 (AR-12)","OSU03012 (AR12)","PDK1 inhibitor AR-12","PDK1 inhibitor AR12",UNII-EX3O2Q61UV,UNIIEX3O2Q61UV,"AR 1
2",EX3O2Q61UV,CHEMBL1650595,"742112-33-0 (free base)","742112330 (free base)","AR-12 (OSU-03012)","AR12 (OSU03012)",PubChem22592,MLS006010170,SCHEMBL570472,GTPL8005,T2466,S1106,Osu-03012}

> <pdid>
PD011134

> <targets>
{PDK-1}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{10027278}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  1  0            999 V2000
    7.6965    0.1381    0.0000 C   0  0
    7.6436    1.6371    0.0000 C   0  0
    8.9156    2.4321    0.0000 O   0  0
    6.3180    2.3408    0.0000 N   0  0
    5.0452    1.5454    0.0000 C   0  0
    3.7196    2.2491    0.0000 C   0  0
    3.6667    3.7482    0.0000 O   0  0
    2.4570    1.4647    0.0000 N   0  0
    1.2285    1.2600    0.0000 C   0  0  1  0  0  0
    2.5672    0.5197    0.0000 C   0  0
    2.5672   -1.0867    0.0000 C   0  0
    1.3860   -0.2520    0.0000 C   0  0  1  0  0  0
    0.0000   -0.8820    0.0000 C   0  0
   -1.2757   -1.6380    0.0000 C   0  0
   -2.5357   -0.8820    0.0000 C   0  0
   -3.8535   -1.6021    0.0000 N   0  0
   -5.1355   -0.8218    0.0000 C   0  0
   -6.4530   -1.5391    0.0000 N   0  0
   -7.7329   -0.7570    0.0000 C   0  0
   -7.6954    0.7426    0.0000 C   0  0
   -6.3781    1.4599    0.0000 C   0  0
   -6.3376    2.9602    0.0000 N   0  0
   -5.0185    3.6761    0.0000 C   0  0
   -4.6347    5.0888    0.0000 C   0  0
   -3.1974    4.6595    0.0000 C   0  0
   -3.6267    3.2222    0.0000 C   0  0
   -5.0982    0.6778    0.0000 N   0  0
   -8.9761    1.5252    0.0000 C   0  0
  -10.2939    0.8087    0.0000 F   0  0
   -8.9382    3.0247    0.0000 F   0  0
  -10.2556    2.3080    0.0000 F   0  0
   -2.5357    0.5197    0.0000 C   0  0
   -1.2757    1.2600    0.0000 C   0  0
    0.0000    0.5355    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  6
 10 11  1  0
 12 11  1  1
 12  8  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 23  1  0
 21 27  2  0
 27 17  1  0
 20 28  1  0
 28 29  1  0
 28 30  1  0
 28 31  1  0
 15 32  2  0
 32 33  1  0
 33 34  2  0
 34  9  1  0
 34 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28548

> <plate>
Kinase v5-2

> <well>
M10

> <supplier_cmpd_name>
PF-03814735

> <ctcr_id>
7736

> <supplier_cmpd_id>
S2725

> <smiles>
CC(=O)NCC(=O)N1[C@H]2CC[C@H]1c3cc(Nc4ncc(c(NC5CCC5)n4)C(F)(F)F)ccc23

> <pd_targets>
{AURKA,AURKB,MELK,JAK3,DYRK1B,MAP3K20,LCK,PIM3,MAPK8,CHEK2,PRKCG,CLK4,MAP4K5,CAMK1D,CAMK2A,MATK,DYRK1A,STK3,CSNK1G1,CHEK1,LRRK2,IKBKE,CAMK2B,NEK2,PRKACA,FLT1,FER,PDGFRB,ABL1,MINK1,PAK4,IRAK1,TSSK1B,HI
PK2,MET,GSK3B,CDK1,NTRK2,MAP2K1,NTRK3,MAP4K4,RPS6KB1,TBK1,CSF1R,LTK,BRSK1,RPS6KA3,PHKG2,CLK2,NTRK1,MAPK9,TYRO3,DAPK3,PTK6,BTK,ROCK2,ROCK1,ERBB4,MARK3,SGK2,PRKX,FGFR1,PTK2,CDK5,MAP4K2,EPHA2,PRKD3,PKN2,
IGF1R,MAPK13,HIPK4,FGFR3,DCLK1,CAMK2G,CSNK1G2,MST1R,PRKCQ,PRKD2,FRK,PRKCD,TAOK1,TNK2,CSNK1D,GRK5,ITK,TSSK2,PDGFRA,CDK7,CDK9,SLK,PLK1,CDC42BPA,SYK,KDR,KIT,JAK2,PRKAA1,LIMK1,STK17A,MAPK1,ROS1,FES,INSR,M
KNK2,DYRK3,CAMK2D,SRC,CDK2,IRAK4,CSNK2A1,GSK3A,SRPK1,TYK2,BLK,NEK4,CDC7,ACVR1,MAPK12,PDPK1,ALK,PLK4,RET,MAP2K2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","CAMK protein kinase group","TK protein kinase group","CMGC protein kinase group","TKL protein kinase group","AGC protein kinase group","ST
E protein kinase group","CK1 protein kinase group","Other protein kinase AUR family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase JakA family","CMGC protein kinase DYRK family","TKL pro
tein kinase MLK family","Tyrosine protein kinase Src family","CAMK protein kinase PIM family","CMGC protein kinase MAPK family","CAMK protein kinase RAD53 family","AGC protein kinase PKC family","CMGC
 protein kinase CLK family","STE protein kinase STE20 family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Csk family","CK1 protein kinase CK1 family","TKL protein kinase LRRK family","
Other protein kinase NEK family","AGC protein kinase PKA family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Fer family","Tyrosine protein kinase PDGFR family","Tyrosine protein ki
nase Abl family","TKL protein kinase IRAK family","CAMK protein kinase TSSK family","Tyrosine protein kinase Met family","CMGC protein kinase GSK family","CMGC protein kinase CDK family","Tyrosine pro
tein kinase Trk family","STE protein kinase STE7 family","AGC protein kinase RSK family","Other protein kinase IKK family","Tyrosine protein kinase Alk family","CAMK protein kinase PHk family","Tyrosi
ne protein kinase Axl family","CAMK protein kinase DAPK family","Tyrosine protein kinase Tec family","AGC protein kinase DMPK family","Tyrosine protein kinase EGFR family","AGC protein kinase SGK fami
ly","Tyrosine protein kinase FGFR family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Eph family","CAMK protein kinase PKD family","AGC protein kinase PKN family","Tyrosine protein k
inase InsR family","CAMK protein kinase DCAMK1 family","Tyrosine protein kinase Ack family","AGC protein kinase GRK family","Other protein kinase PLK family","Tyrosine protein kinase Syk family","TKL 
protein kinase LISK family","Tyrosine protein kinase Sev family","CAMK protein kinase MAPKAPK family","Other protein kinase CK2 family","CMGC protein kinase SRPK family","Other protein kinase CDC7 fam
ily","TKL protein kinase STKR family","AGC protein kinase PDK1 subfamily","Tyrosine protein kinase Ret family","CAMK protein kinase MELK subfamily","CMGC protein kinase Dyrk1 subfamily","TKL protein k
inase MLK subfamily","CMGC protein kinase JNK subfamily","AGC protein kinase PKC alpha subfamily","STE protein kinase KHS subfamily","STE protein kinase MST subfamily","CAMK protein kinase CHK1 subfam
ily","STE protein kinase MSN subfamily","STE protein kinase PAKB subfamily","CMGC protein kinase HIPK subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase p70 subfamily","CAMK protein k
inase BRSK subfamily","AGC protein kinase RSK subfamily","AGC protein kinase ROCK subfamily","CAMK protein kinase MARK subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase p38 subfamil
y","AGC protein kinase PKC delta subfamily","STE protein kinase TAO subfamily","AGC protein kinase GRK subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","STE protein
 kinase SLK subfamily","AGC protein kinase GEK subfamily","CAMK protein kinase AMPK subfamily","TKL protein kinase LIMK subfamily","CMGC protein kinase ERK1","CAMK protein kinase MNK subfamily","CMGC 
protein kinase Dyrk2 subfamily","TKL protein kinase STKR1","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing
 PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","Other protein kinases","CAMK-like (CAMKL) family","TK: Tyrosine kinase","Dual-spec
ificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","TKL: Tyrosine kinase-like","PIM family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase C (PKC) family","CLK fam
ily","STE20 family","CAMK1 family","CAMK2 family","Casein kinase 1 (CK1) family","Protein kinase A (PKA) family","Testis specific kinase (TSSK) family","Glycogen synthase kinase (GSK) family","Cyclin-
dependent kinase (CDK) family","STE7 family","RSK family","Phosphorylase kinase (PHK) family","Death-associated kinase (DAPK) family","DMPK family","SGK family","Protein kinase D (PKD) family","Protei
n kinase N (PKN) family","DCAMKL family","G protein-coupled receptor kinases (GRKs)","MAPK-Activated Protein Kinase (MAPKAPK) family","SRPK family","PDK1 family","Aurora kinase (Aur) family","MELK sub
family","Non-receptor tyrosine kinases (nRTKs)","Dyrk1 subfamily","Mixed Lineage Kinase (MLK) family","JNK subfamily","CHK1 subfamily","Alpha subfamily","KHS subfamily","MST subfamily","Leucine-rich r
epeat kinase (LRRK) family","IKK family","NIMA (never in mitosis gene a)- related kinase (NEK) family","Receptor tyrosine kinases (RTKs)","MSN subfamily","PAKB subfamily","Interleukin-1 receptor-assoc
iated kinase (IRAK) family","HIPK subfamily","GSK subfamily","CDK1 subfamily","p70 subfamily","BRSK subfamily","RSK subfamily","Rho kinase","MARK subfamily","CDK5 subfamily","p38 subfamily","Delta sub
family","TAO subfamily","GRK4 subfamily","CDK7 subfamily","CDK9 subfamily","SLK subfamily","Polo-like kinase (PLK) family","GEK subfamily","AMPK subfamily","LIM domain kinase (LISK) family","ERK subfa
mily","MKN subfamily","Dyrk2 subfamily","Casein kinase 2 (CK2) family","CDC7 family","Receptor serine/threonine kinase (RSTK) family","Janus kinase (JakA) family","MLK subfamily","Src family","Csk fam
ily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Fer family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Abl family","Type X RTKs: HGF (hepatocyte growth fac
tor) receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family",
"Tec family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Fak family","Type XIII RTKs: Ephrin receptor family","Type II 
RTKs: Insulin receptor family","Ack family","Syk family","LIMK subfamily","Type XVII RTKs: ROS receptors","Type I receptor serine/threonine kinases","Type XIV RTKs: RET"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","Immune System",Disease,"Neuronal System","Signal Transduction","DNA Repair","Cellular responses to external stimuli","Developmental Biology",Metabolism
,"Programmed Cell Death","Transport of small molecules","RNA Polymerase II Transcription",Mitotic,"Cytokine Signaling in Immune system","Infectious disease","Innate Immune System","Transmission across
 Chemical Synapses","Signaling by Receptor Tyrosine Kinases","Signaling by Hippo","DNA Double-Strand Break Repair","Signaling by Non-Receptor Tyrosine Kinases","Intracellular signaling by second messe
ngers","Cellular responses to stress","Nervous system development","MTOR signalling","Metabolism of carbohydrates",Apoptosis,"Diseases of signal transduction by growth factor receptors and second mess
engers","Ion channel transport","Metabolism of lipids","Signaling by Rho GTPases","Signaling by GPCR","Adaptive Immune System","Generic Transcription Pathway","M Phase","Signaling by Interleukins","HI
V Infection","Toll-like Receptor Cascades","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by ERBB2","Mitotic G1 phase and G1/S transition","Homology Directed Repair","Sig
naling by PTK6","Regulation of mitotic cell cycle","Mitotic G2-G2/M phases","Signaling by VEGF","Signaling by SCF-KIT","PIP3 activates AKT signaling","Leishmania infection","Cellular Senescence","Axon
 guidance","SARS-CoV Infections","Signaling by NTRKs","mTORC1-mediated signalling","Glycogen metabolism","Caspase activation via extrinsic apoptotic signalling pathway","Oncogenic MAPK signaling","Sti
muli-sensing channels","Signaling by FGFR in disease","Sphingolipid metabolism","RHO GTPase Effectors","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Signaling by MST1","GPCR dow
nstream signalling","DAG and IP3 signaling","TCR signaling","Signaling by PDGFR in disease","Signaling by KIT in disease","Interferon Signaling","Transcriptional Regulation by TP53","Mitotic Metaphase
 and Anaphase","Interleukin-2 family signaling","Host Interactions of HIV factors","Toll Like Receptor 5 (TLR5) Cascade","Glutamate binding","activation of AMPA receptors and synaptic plasticity","Act
ivation of NMDA receptors and postsynaptic events","Downregulation of ERBB2 signaling","G0 and Early G1","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","PTK6 promotes HI
F1A stabilization","Toll Like Receptor 4 (TLR4) Cascade","APC/C-mediated degradation of cell cycle proteins","G2/M Transition","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AKT 
network","Parasite infection","Oxidative Stress Induced Senescence","Signaling by ROBO receptors","Semaphorin interactions","SARS-CoV-1 Infection","Signaling by NTRK1 (TRKA)","Signaling by NTRK3 (TRKC
)","Transcriptional Regulation by VENTX","Glycogen breakdown (glycogenolysis)","Caspase activation via Dependence Receptors in the absence of ligand","G1 Phase","Signaling by RAS mutants","Leishmania 
parasite growth and survival","Signaling by FGFR1 in disease","EPH-Ephrin signaling","Sphingolipid de novo biosynthesis","RHO GTPases activate PKNs","IGF1R signaling cascade","Signaling by FGFR3 in di
sease","G alpha (i) signalling events","PTEN Regulation","CaM pathway","G alpha (q) signalling events","Generation of second messenger molecules","Drug resistance of PDGFR mutants","HIV Life Cycle","V
EGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","Toll Like Receptor 2 (TLR2) Cascade","Interferon alpha/beta signaling","Transcriptional regulation by RUNX1","G1/S Transition","RET signaling","R
egulation of TP53 Activity","Mitotic Anaphase","Interleukin-15 signaling","The role of Nef in HIV-1 replication and disease pathogenesis","MyD88 cascade initiated on plasma membrane","Trafficking of A
MPA receptors","Post NMDA receptor activation events","HDR through Homologous Recombination (HRR)","MyD88-independent TLR4 cascade","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic
 proteins","Centrosome maturation","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Leishmania phagocytosis","Activation of RAC1","Sema4D in sem
aphorin signaling","SARS-CoV-1 Genome Replication and Transcription","Activation of TRKA receptors","Signalling to ERKs","Activated NTRK3 signals through PI3K","Cyclin D associated events in G1","Sign
aling downstream of RAS mutants","Anti-inflammatory response favouring Leishmania parasite infection","FGFR1 mutant receptor activation","EPHA-mediated growth cone collapse","IRS-related events trigge
red by IGF1R","Signaling by FGFR3 point mutants in cancer","Visual phototransduction","Regulation of PTEN stability and activity","Calmodulin induced events","Imatinib-resistant PDGFR mutants","Late P
hase of HIV Life Cycle","VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","CRMPs in Sema3A signaling","Toll Like Receptor TLR6:TLR2 Cascade","Regulation of IFNA signaling","RUNX1 
regulates transcription of genes involved in BCR signaling","Activation of the pre-replicative complex","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids","Nef-med
iates down modulation of cell surface receptors by recruiting them to clathrin adapters","MAP kinase activation","Regulation of TP53 Expression and Degradation","Trafficking of GluR2-containing AMPA r
eceptors","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Homologous DNA Pairing and Strand Exchange","TRIF(TICAM1)-mediated TLR4 signaling","APC/C:Cdc20 mediated d
egradation of mitotic proteins","Loss of proteins required for interphase microtubule organization from the centrosome","FCGR3A-mediated phagocytosis","Sema4D mediated inhibition of cell attachment an
d migration","Replication of the SARS-CoV-1 genome","NGF-independant TRKA activation","Prolonged ERK activation events","Sema4D induced cell migration and growth-cone collapse","Long-term potentiation
","ADORA2B mediated anti-inflammatory cytokines production","Signaling by activated point mutants of FGFR1","Signalling to RAS","FGFR3 mutant receptor activation","The phototransduction cascade","Tran
scription of the HIV genome","FCGR3A-mediated IL10 synthesis","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP k
inases","Regulation of TP53 Degradation","Ras activation upon Ca2+ influx through NMDA receptor","Presynaptic phase of homologous DNA pairing and strand exchange","Activation of IRF3/IRF7 mediated by 
TBK1/IKK epsilon","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK act
ivation","Frs2-mediated activation","ARMS-mediated activation","p38MAPK events","Signaling by activated point mutants of FGFR3",Inactivation,"recovery and regulation of the phototransduction cascade",
"HIV Transcription Elongation","Activation of the AP-1 family of transcription factors","APC-Cdc20 mediated degradation of Nek2A","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","CREB phosphory
lation","Tat-mediated elongation of the HIV-1 transcript","ERK/MAPK targets","Formation of HIV-1 elongation complex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
{AURKA,AURKB}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{ZINC100015731,NCGC00346652-01,NCGC0034665201,S2725,PF-03814735}

> <pdid>
PD012745

> <targets>
{"Aurora Kinase",FAK}

> <classes>
{}

> <pubchem_cids>
{73265213}

$$$$
UTKinase_V5
  SciTegic11012413002D

 16 18  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5536   -4.4230    0.0000 C   0  0
   -4.0444   -4.5346    0.0000 C   0  0
   -4.6946   -5.8864    0.0000 C   0  0
   -3.8489   -7.1253    0.0000 N   0  0
   -2.3532   -7.0124    0.0000 C   0  0
   -1.7031   -5.6606    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10  2  1  0
 10  6  2  0
  8 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28549

> <plate>
Kinase v5-2

> <well>
M12

> <supplier_cmpd_name>
PHA-767491

> <ctcr_id>
2552

> <supplier_cmpd_id>
S2742

> <smiles>
O=C1NCCc2[nH]c(cc12)c3ccncc3

> <pd_targets>
{ROCK1,MAPK12,PRKCQ,PRKD2,PKN2,GSK3B,CDK2,PLK1,SLK,PRKCD,RPS6KB1,HIPK4,ACVR1,CDK8,CDK1,CDC7,RPS6KA4,MAPKAPK2,MAPK13,MAPKAPK3,RPS6KA5,CDK9,CHEK2,PRKACA,MKNK2,PRKG1,CSNK2A1,GSK3A,CDK5,CDC42BPA,PLK4,PASK
,DAPK3,MINK1,DYRK3,DYRK4,ROCK2,JAK3,MARK2,MKNK1,CSNK1G2,BRSK1,RPS6KA3,PRKG2,CLK2,TAOK1,CSNK1D,NEK4,CSNK1G1,CLK4,MAPK1,PRKCZ,CSNK1G3,PLK3,SGK2,LRRK2,STK17A,PRKX,IRAK4,PIM3,PBK,MAP4K2,PRKD3,HIPK2,MAPKAP
K5,AKT1,DYRK1A,DYRK1B,IRAK1,CSNK1A1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","CMGC protein kinase group","CAMK protein kinase group","Other protein kinase group","STE protein kinase group","TKL protein kinase group","T
K protein kinase group","CK1 protein kinase group","AGC protein kinase DMPK family","CMGC protein kinase MAPK family","AGC protein kinase PKC family","CAMK protein kinase PKD family","AGC protein kina
se PKN family","CMGC protein kinase GSK family","CMGC protein kinase CDK family","Other protein kinase PLK family","STE protein kinase STE20 family","AGC protein kinase RSK family","CMGC protein kinas
e DYRK family","TKL protein kinase STKR family","Other protein kinase CDC7 family","CAMK protein kinase MAPKAPK family","CAMK protein kinase RAD53 family","AGC protein kinase PKA family","AGC protein 
kinase PKG family","Other protein kinase CK2 family","CAMK protein kinase CAMK1 family","CAMK protein kinase DAPK family","Tyrosine protein kinase JakA family","CK1 protein kinase CK1 family","CMGC pr
otein kinase CLK family","Other protein kinase NEK family","AGC protein kinase SGK family","TKL protein kinase LRRK family","TKL protein kinase IRAK family","CAMK protein kinase PIM family","Other pro
tein kinase TOPK family","AGC protein kinase AKT family","AGC protein kinase ROCK subfamily","CMGC protein kinase p38 subfamily","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDC2 subf
amily","STE protein kinase SLK subfamily","AGC protein kinase p70 subfamily","CMGC protein kinase HIPK subfamily","TKL protein kinase STKR1","CMGC protein kinase CDK8 subfamily","AGC protein kinase MS
K subfamily","CAMK protein kinase MAPKAPK subfamily","CMGC protein kinase CDK9 subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase CDK5 subfamily","AGC protein kinase GEK subfamily","C
AMK protein kinase PASK subfamily","STE protein kinase MSN subfamily","CMGC protein kinase Dyrk2 subfamily","CAMK protein kinase MARK subfamily","CAMK protein kinase BRSK subfamily","AGC protein kinas
e RSK subfamily","STE protein kinase TAO subfamily","CMGC protein kinase ERK1","AGC protein kinase PKC iota subfamily","CK1 protein kinase CK1-g","STE protein kinase KHS subfamily","CMGC protein kinas
e Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kin
ases","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","DMPK family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase C (
PKC) family","Protein kinase D (PKD) family","Protein kinase N (PKN) family","Glycogen synthase kinase (GSK) family","Cyclin-dependent kinase (CDK) family","Other protein kinases","STE20 family","RSK 
family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","CAMK-like (CAMKL) family","Protein 
kinase A (PKA) family","Protein kinase G (PKG) family","Death-associated kinase (DAPK) family","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","CLK family","SGK family","PIM family","Akt (Protein
 kinase B","PKB) family","Rho kinase","p38 subfamily","Delta subfamily","GSK subfamily","CDK1 subfamily","Polo-like kinase (PLK) family","SLK subfamily","p70 subfamily","HIPK subfamily","Receptor seri
ne/threonine kinase (RSTK) family","CDK8 subfamily","CDC7 family","MSK subfamily","MAPKAPK subfamily","CDK9 subfamily","CHK1 subfamily","MKN subfamily","Casein kinase 2 (CK2) family","CDK5 subfamily",
"GEK subfamily","PASK subfamily","MSN subfamily","Dyrk2 subfamily","Dyrk1 subfamily","Non-receptor tyrosine kinases (nRTKs)","MARK subfamily","BRSK subfamily","RSK subfamily","TAO subfamily","NIMA (ne
ver in mitosis gene a)- related kinase (NEK) family","ERK subfamily","Iota subfamily","Leucine-rich repeat kinase (LRRK) family","Interleukin-1 receptor-associated kinase (IRAK) family","TOPK family",
"KHS subfamily","Type I receptor serine/threonine kinases","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction",Metabolism,Disease,"Gene expression (Transcription)","Cell Cycle","Immune System",Hemostasis,"Programmed Cell Death","Cellular responses to external stim
uli","Transport of small molecules","Nervous system development","Signaling by Receptor Tyrosine Kinases","Signaling by GPCR","Metabolism of lipids","Signaling by Rho GTPases","Infectious disease","RN
A Polymerase II Transcription",Mitotic,"Intracellular signaling by second messengers","MTOR signalling","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immun
e System","Platelet homeostasis",Apoptosis,"Cellular responses to stress","Cytokine Signaling in Immune system","MAPK family signaling cascades","Signaling by Nuclear Receptors","Ion channel transport
","Signaling by Non-Receptor Tyrosine Kinases","Axon guidance","Signaling by NTRKs","GPCR downstream signalling","Sphingolipid metabolism","RHO GTPase Effectors","SARS-CoV Infections","Generic Transcr
iption Pathway","Mitotic G2-G2/M phases","DAG and IP3 signaling","mTORC1-mediated signalling","Signaling by NOTCH1 in Cancer","Regulation of mitotic cell cycle","Mitotic G1 phase and G1/S transition",
"Toll-like Receptor Cascades","HIV Infection","Nitric oxide stimulates guanylate cyclase","Caspase activation via extrinsic apoptotic signalling pathway","Cellular Senescence","Signaling by Interleuki
ns","Signaling by FGFR","MAPK1/MAPK3 signaling","M Phase","ESR-mediated signaling","Stimuli-sensing channels","Signaling by PTK6","Leishmania infection","Signaling by WNT in cancer","Semaphorin intera
ctions","Signaling by NTRK1 (TRKA)","G alpha (i) signalling events","Sphingolipid de novo biosynthesis","RHO GTPases activate PKNs","SARS-CoV-1 Infection","Transcriptional Regulation by TP53","G2/M Tr
ansition","CaM pathway","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","APC/C-mediated degradation of cell cycle proteins","G1/S Transition","L1CAM interactions","Toll Like Receptor 5 (TLR5) C
ascade","HIV Life Cycle","cGMP effects","Caspase activation via Dependence Receptors in the absence of ligand","Oxidative Stress Induced Senescence","Interleukin-2 family signaling","Signaling by FGFR
4","RAF/MAP kinase cascade","Mitotic Metaphase and Anaphase","Extra-nuclear estrogen signaling","PTK6 promotes HIF1A stabilization","Leishmania parasite growth and survival","Toll Like Receptor 2 (TLR
2) Cascade","G0 and Early G1","Signaling by AMER1 mutants","Sema4D in semaphorin signaling","Signalling to ERKs","Visual phototransduction","SARS-CoV-1 Genome Replication and Transcription","Regulatio
n of TP53 Activity","Centrosome maturation","Calmodulin induced events","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic p
roteins","Activation of the pre-replicative complex","Recycling pathway of L1","MyD88 cascade initiated on plasma membrane","Late Phase of HIV Life Cycle","Interleukin-15 signaling","Negative regulati
on of FGFR4 signaling","RAS processing","Mitotic Anaphase","Estrogen-stimulated signaling through PRKCZ","Anti-inflammatory response favouring Leishmania parasite infection","Toll Like Receptor TLR6:T
LR2 Cascade","Truncations of AMER1 destabilize the destruction complex","Sema4D induced cell migration and growth-cone collapse","Signalling to RAS","The phototransduction cascade","Replication of the
 SARS-CoV-1 genome","Regulation of TP53 Expression and Degradation","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic
 proteins","MAP kinase activation","Transcription of the HIV genome","Regulation of TP53 Activity through Phosphorylation","Spry regulation of FGF signaling","Separation of Sister Chromatids","ADORA2B
 mediated anti-inflammatory cytokines production","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","p38MAPK events",Inactivation,"recovery and regulation of the phototransduction cascade","Regu
lation of TP53 Degradation","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","MAPK targets/ Nuclear even
ts mediated by MAP kinases","activated TAK1 mediates p38 MAPK activation","HIV Transcription Elongation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","CREB phosphorylation","Tat-mediated elo
ngation of the HIV-1 transcript","ERK/MAPK targets","Formation of HIV-1 elongation complex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
{CDK1,RPS6KB1}

> <broad_moa>
{"CDC inhibitor"}

> <synonyms>
{PHA-767491,PHA767491,845714-00-3,845714003,CAY10572,"PHA 767491","compound 8 (PMID: 17480064)","2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo(3,2-c)pyridin-4-one","2pyridin4yl1,5,6,7tetrahydropyrrolo(3,2c
)pyridin4one",PHA-767491A,PHA767491A,CAY10572(PHA-767491),CAY10572(PHA767491),"1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo(3,2-c)pyridin-4-one","1,5,6,7Tetrahydro2(4pyridinyl)4Hpyrrolo(3,2c)pyridin4
one",2-(pyrid,2(pyrid,T6940,S2742,"EMD 217707","PHA767491 HCl",217707}

> <pdid>
PD010690

> <targets>
{CDK,"Cdc7/Cdk9 Inhibitor"}

> <classes>
{}

> <pubchem_cids>
{11715767}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 N   0  0
    6.2815   -1.5087    0.0000 C   0  0
    7.7400   -1.8590    0.0000 C   0  0
    8.7727   -0.7711    0.0000 C   0  0
    8.3468    0.6672    0.0000 C   0  0
    9.3795    1.7552    0.0000 O   0  0
    6.8883    1.0176    0.0000 C   0  0
    5.8557   -0.0704    0.0000 C   0  0
    4.3570   -0.0307    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15  9  1  0
 15 16  1  0
 16  7  2  0
  6 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23  4  1  0
 23 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28550

> <plate>
Kinase v5-2

> <well>
M14

> <supplier_cmpd_name>
PP242

> <ctcr_id>
1626

> <supplier_cmpd_id>
S2218

> <smiles>
CC(C)n1nc(c2[nH]c3ccc(O)cc3c2)c4c(N)ncnc14

> <pd_targets>
{DYRK1A,PI4KB,PIK3CA,PIK3CG,MTOR,ABL1,EGFR,EPHB4,MAP2K4,BRSK2,CSNK1A1L,CAMK1D,CLK2,EPHA3,FGR,FLT1,FLT3,IRAK4,KIT,MAP2K2,MLST8,RPTOR,MAP2K5,ANKK1,LCK,EPHA5,SIK2,PAK5,NLK,MYO3A,TNK2,BRD4,CSNK2A2,ERBB3,B
MPR1B,CDK8,AXL,BLK,MAP4K1,ABL2,PIM3,BRAF,EPHA6,MKNK1,ACVR2A,MAP3K3,PIK3C2B,MAP2K3,EIF2AK2,GAK,HIPK3,PLK4,BMP2K,HIPK2,STK35,MAP3K20,MAP3K7,PIP4K2C,MAP3K19,CSNK1G1,MAP4K4,MAP3K1,PRKCE,STK10,NTRK2,PLK2,C
DK19,MARK2,STK26,PDGFRA,PIM2,MERTK,PAK4,RPS6KA6,FGFR3,DAPK1,PIM1,STK17B,RET,LRRK2,CAMK2A,EPHA4,EPHA8,EPHB1,EPHB2,LTK,MAP2K1,CSNK1G2,FRK,HCK,LYN,PIK3CD,PLK3,EPHA2,TGFBR2,JAK3,CLK1,CSNK1D,DAPK3,FGFR2,MA
PKAP1,RICTOR,DDR1,ACVR2B,EPHB6,MAP4K2,STK16,ERBB2,TAOK1,PIK3CB,BTK,CDK4,MYO3B,CDK7,TNK1,DAPK2,AAK1,TNIK,MYLK,MAP3K9,AKT3,MKNK2,RIOK2,KDR,SIK3,CHEK2,JAK1,RIPK2,DMPK,STK33,FGFR4,FYN,PTK6,PHKG2,PRKACA,PR
KG2,RPS6KB1,RPS6KA4,FLT4,MINK1,RPS6KA1,PRKCH,CSF1R,CSK,CSNK1A1,GRK7,PAK2,STK32A,GRK1,JAK2,DYRK2,NTRK1,ACVR1B,ACVR1,PIK3C2G,IRAK3,TNNI3K,STK32B,RIPK4,CSNK2A1,HIPK1,STK3,MYLK3,PIP5K1C,SLK,BMPR2,BMX,ROS1
,BMPR1A,CSNK1G3,TTK,TEK,PAK6,RPS6KA3,TAOK2,RPS6KA5,PRKDC,COQ8B,PKNB,CDPK1,DSTYK,SRC,YES1,TYK2,FGFR1,EPHA1,CASK,ALK,BRSK1,CAMKK2,ULK3,IRAK1,TXK,TGFBR1,TESK1,LATS2,MELK,TAOK3,CLK4,HIPK4,SIK1,MAP3K2,COQ8
A,ULK2,PDGFRB,CSNK1E,MAPK14,DDR2,ACVRL1,NUAK2,DCLK3,PASK}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Unclassified protein",Kinase,Transferase,Reader,"Protein Kinase",Bromodomain,"CMGC protein kinase group","Atypical protein kinase group","TK protein kinase group","STE 
protein kinase group","CAMK protein kinase group","CK1 protein kinase group","TKL protein kinase group","Other protein kinase group","AGC protein kinase group","CMGC protein kinase DYRK family","Atypi
cal protein kinase PIKK family","Tyrosine protein kinase Abl family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Eph family","STE protein kinase STE7 family","CAMK protein kinase CA
MK1 family","CK1 protein kinase CK1 family","CMGC protein kinase CLK family","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","TKL pro
tein kinase IRAK family","TKL protein kinase RIPK family","STE protein kinase STE20 family","CMGC protein kinase MAPK family","Tyrosine protein kinase Ack family","Other protein kinase CK2 family","TK
L protein kinase STKR family","CMGC protein kinase CDK family","Tyrosine protein kinase Axl family","CAMK protein kinase PIM family","TKL protein kinase RAF family","CAMK protein kinase MAPKAPK family
","STE protein kinase STE11 family","Other protein kinase PEK family","Other protein kinase NAK family","Other protein kinase PLK family","Other protein kinase NKF4 family","TKL protein kinase MLK fam
ily","AGC protein kinase PKC family","Tyrosine protein kinase Trk family","AGC protein kinase RSK family","Tyrosine protein kinase FGFR family","CAMK protein kinase DAPK family","Tyrosine protein kina
se Ret family","TKL protein kinase LRRK family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Alk family","Tyrosine protein kinase JakA family","Tyrosine protein kinase DDR family","Tyro
sine protein kinase Tec family","CAMK protein kinase MLCK family","AGC protein kinase AKT family","Atypical protein kinase RIO family","CAMK protein kinase RAD53 family","AGC protein kinase DMPK famil
y","CAMK protein kinase unique family","CAMK protein kinase PHk family","AGC protein kinase PKA family","AGC protein kinase PKG family","Tyrosine protein kinase Csk family","AGC protein kinase GRK fam
ily","AGC protein kinase YANK family","Tyrosine protein kinase Sev family","Other protein kinase TTK family","Tyrosine protein kinase Tie family","Atypical protein kinase ABC1 family","Other protein k
inase CAMKK family","Other protein kinase ULK family","TKL protein kinase LISK family","AGC protein kinase NDR family","CAMK protein kinase DCAMK1 family","CMGC protein kinase Dyrk1 subfamily","Atypic
al protein kinase FRAP subfamily","CAMK protein kinase BRSK subfamily","CK1 protein kinase CK1-a","CAMK protein kinase QIK subfamily","STE protein kinase PAKB subfamily","CMGC protein kinase nmo subfa
mily","STE protein kinase NinaC subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase CDK8 subfamily","STE protein kinase KHS subfamily","CAMK protein kinase MNK subfamily","TKL p
rotein kinase STKR Type 2 subfamily","STE protein kinase MEKK2","Other protein kinase PKR","CMGC protein kinase HIPK subfamily","TKL protein kinase MLK subfamily","TKL protein kinase TAK1 subfamily","
STE protein kinase MSN subfamily","AGC protein kinase PKC eta subfamily","STE protein kinase SLK subfamily","Other protein kinase PLK2","CAMK protein kinase MARK subfamily","STE protein kinase YSK sub
family","AGC protein kinase RSK subfamily","STE protein kinase TAO subfamily","CMGC protein kinase CDK7 subfamily","Atypical protein kinase RIO2 subfamily","AGC protein kinase GEK subfamily","Tyrosine
 protein kinase SrcA","AGC protein kinase p70 subfamily","AGC protein kinase MSK subfamily","AGC protein kinase GRK subfamily","STE protein kinase PAKA subfamily","CMGC protein kinase Dyrk2 subfamily"
,"TKL protein kinase STKR1","TKL protein kinase HH498 subfamily","STE protein kinase MST subfamily","CK1 protein kinase CK1-g","Atypical protein kinase ABC1-A subfamily","Other protein kinase Meta sub
family","TKL protein kinase TESK subfamily","CAMK protein kinase MELK subfamily","CMGC protein kinase p38 subfamily","CAMK protein kinase NuaK subfamily","CAMK protein kinase PASK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Chromatin modifying enzymes","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Lipid modifying kinases",Atypical,"Receptor kinases","STE
: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CK1: Casein kinase 1","Enzymatic bromodomain-containing proteins","AGC: Containin
g PKA",PKG,"PKC families","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","1-phosphatidylinositol 4-kinase family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family
","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","TK: Tyrosine kinase","STE7 family","CAMK-like (CAMKL) family","Casein kinase 1 (CK1) family","CAMK1 family","CLK family","TKL: Tyrosi
ne kinase-like","STE20 family","Mitogen-activated protein kinases (MAP kinases)","Bromodomain kinase (BRDK) family","Other protein kinases","Cyclin-dependent kinase (CDK) family","PIM family","MAPK-Ac
tivated Protein Kinase (MAPKAPK) family","STE11 family","Phosphatidylinositol-4-phosphate 3-kinase family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Protein kinase C 
(PKC) family","RSK family","Death-associated kinase (DAPK) family","CAMK2 family","Myosin Light Chain Kinase (MLCK) family","Akt (Protein kinase B","PKB) family","RIO family","DMPK family","CAMK-uniqu
e family","Phosphorylase kinase (PHK) family","Protein kinase A (PKA) family","Protein kinase G (PKG) family","G protein-coupled receptor kinases (GRKs)","YANK family","Type I PIP kinases (1-phosphati
dylinositol-4-phosphate 5-kinase family)","ABC1 family","CASK family","NDR family","DCAMKL family","Dyrk1 subfamily","FRAP subfamily","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases
 (RTKs)","BRSK subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","Receptor interacting protein kinase (RIPK) family","QIK subfamily","PAKB subfamily","nmo subfamily","NinaC subfamily
","Casein kinase 2 (CK2) family","Receptor serine/threonine kinase (RSTK) family","CDK8 subfamily","KHS subfamily","RAF family","MKN subfamily","PEK family","Numb-associated kinase (NAK) family","HIPK
 subfamily","Polo-like kinase (PLK) family","NKF4 family","Mixed Lineage Kinase (MLK) family","STE20 subfamily","MSN subfamily","Eta subfamily","SLK subfamily","MARK subfamily","YSK subfamily","RSK su
bfamily","Leucine-rich repeat kinase (LRRK) family","NAK family","TAO subfamily","CDK4 subfamily","CDK7 subfamily","RIO2 subfamily","CHK1 subfamily","GEK subfamily","p70 subfamily","MSK subfamily","Op
sin/rhodopsin kinases","PAKA subfamily","Dyrk2 subfamily","MST subfamily","TTK family","Other PIKK family kinases","ABC1-B subfamily","Other-unique family","CAMKK family","Unc-51-like kinase (ULK) fam
ily","LIM domain kinase (LISK) family","MELK subfamily","p38 subfamily","NuaK subfamily","PASK subfamily","Abl family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XIII RTKs: Ep
hrin receptor family","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Ack family","Type I receptor serine
/threonine kinases","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type II receptor serine/threonine kinases","Other PEK family kinases","MLK subfamily","TAK1 subfamily","Type VII RTK
s: Neurotrophin receptor/Trk family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type XIV RTKs: RET","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Janus kinase (
JakA) family","Type XVI RTKs: DDR (collagen receptor) family","Tec family","Csk family","HH498 subfamily","Type XVII RTKs: ROS receptors","Type XII RTKs: TIE family of angiopoietin receptors","Meta su
bfamily","TESK subfamily"}

> <pathway_reactome>
{"Cell Cycle",Metabolism,Disease,"Gene expression (Transcription)","Signal Transduction","Developmental Biology","Immune System","Vesicle-mediated transport","Cellular responses to external stimuli","
Programmed Cell Death",Hemostasis,"Neuronal System","Extracellular matrix organization","Metabolism of RNA","Muscle contraction","Cell-Cell communication","Circadian Clock",Mitotic,"Metabolism of lipi
ds","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Infectious disease","Signaling by GPCR","Nervous system development","Innate I
mmune System","Signaling by Receptor Tyrosine Kinases","Signaling by WNT","Intracellular signaling by second messengers","Signaling by TGFB family members","Signaling by NODAL","Cytokine Signaling in 
Immune system","Membrane Trafficking","Cellular responses to stress",Apoptosis,"Cell surface interactions at the vascular wall","Transmission across Chemical Synapses","Signaling by Non-Receptor Tyros
ine Kinases","Non-integrin membrane-ECM interactions","Signaling by Rho GTPases","rRNA processing","Cardiac conduction","Metabolism of carbohydrates","MAPK family signaling cascades","MTOR signalling"
,"Signaling by Hippo","Signaling by Hedgehog","Cell junction organization","Mitotic G1 phase and G1/S transition","Phospholipid metabolism","Signaling by FGFR in disease","Generic Transcription Pathwa
y","Leishmania infection","GPCR downstream signalling","Axon guidance","Toll-like Receptor Cascades","Signaling by VEGF","Signaling by Insulin receptor","Signaling by KIT in disease","Signaling by NTR
Ks","HIV Infection","Beta-catenin independent WNT signaling","SARS-CoV Infections","PIP3 activates AKT signaling","Signaling by BMP","Signaling by NOTCH1 in Cancer","Signaling by FGFR","Regulation of 
signaling by NODAL","Signaling by Interleukins","Influenza Infection","trans-Golgi Network Vesicle Budding","Mitotic G2-G2/M phases","Cellular Senescence","Fcgamma receptor (FCGR) dependent phagocytos
is","Neutrophil degranulation","Regulation of lipid metabolism by PPARalpha","Apoptotic execution phase","Signaling by PDGFR in disease","Neurotransmitter receptors and postsynaptic signal transmissio
n","Caspase activation via extrinsic apoptotic signalling pathway","FLT3 signaling in disease","Signaling by PTK6","Sphingolipid metabolism","Signaling by TGF-beta Receptor Complex in Cancer","M Phase
","Clathrin-mediated endocytosis","RHO GTPase Effectors","rRNA processing in the nucleus and cytosol","Interferon Signaling","Ion homeostasis","Glycogen metabolism","MAPK1/MAPK3 signaling","mTORC1-med
iated signalling","Oncogenic MAPK signaling","Signaling by WNT in cancer","Cytosolic sensors of pathogen-associated DNA","Hedgehog 'on' state","Fc epsilon receptor (FCERI) signaling","Cell-extracellul
ar matrix interactions","G0 and Early G1","PI Metabolism","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","Parasite infection","G alpha (q) signalling events","EPH-Ephrin signalin
g","Toll Like Receptor 5 (TLR5) Cascade","Leishmania parasite growth and survival","VEGF ligand-receptor interactions","Insulin receptor signalling cascade","Toll Like Receptor 2 (TLR2) Cascade","Drug
 resistance of KIT mutants","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Signaling by ROBO receptors","Ca2+ pathway","Potential therapeutics for SARS","Negative regulation of the PI
3K/AKT network","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","VEGFA-VEGFR2 Pathway","Transcriptional regulation by RUNX1","Signaling by FGFR4","Interleukin-1 family signaling","NS1 Mediated 
Effects on Host Pathways","Golgi Associated Vesicle Biogenesis","G2/M Transition","Toll Like Receptor 4 (TLR4) Cascade","Oxidative Stress Induced Senescence","Role of phospholipids in phagocytosis","P
PARA activates gene expression","Apoptotic cleavage of cellular proteins","Drug resistance of PDGFR mutants","Activation of NMDA receptors and postsynaptic events","Signaling by FGFR3 in disease","Cas
pase activation via Dependence Receptors in the absence of ligand","Signaling by FLT3 ITD and TKD mutants","RET signaling","PTK6 promotes HIF1A stabilization","Sphingolipid de novo biosynthesis","PTEN
 Regulation",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Loss of Function of SMAD2/3 in Cancer","Interleukin-2 family signaling","Signaling by FGFR2 in disease","Semaphorin interactions","Mito
tic Metaphase and Anaphase","G1 Phase","HIV Life Cycle","Cargo recognition for clathrin-mediated endocytosis","RHO GTPases activate PAKs","Major pathway of rRNA processing in the nucleolus and cytosol
","Antiviral mechanism by IFN-stimulated genes","Glycogen breakdown (glycogenolysis)","RAF/MAP kinase cascade","L1CAM interactions","G alpha (z) signalling events","Transcriptional Regulation by VENTX
","Signaling by RAS mutants","Signaling by AMER1 mutants","G alpha (i) signalling events","STING mediated induction of host immune responses","Interferon alpha/beta signaling","FCERI mediated Ca+2 mob
ilization","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Synthesis of PIPs at the Golgi membrane","FGFR1 mutant receptor activation","Synthesis of PIPs at the p
lasma membrane","Regulation of TP53 Activity","Leishmania phagocytosis","Gastrin-CREB signalling pathway via PKC and MAPK","EPHB-mediated forward signaling","MyD88 cascade initiated on plasma membrane
","EPHA-mediated growth cone collapse","Anti-inflammatory response favouring Leishmania parasite infection","VEGF binds to VEGFR leading to receptor dimerization","IRS-mediated signalling","Toll Like 
Receptor TLR6:TLR2 Cascade","Dasatinib-resistant KIT mutants","Signalling to ERKs","Signalling to ERK5","The role of Nef in HIV-1 replication and disease pathogenesis","Activation of RAC1",PI5P,"PP2A 
and IER3 Regulate PI3K/AKT Signaling","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","RUNX1 regulates transcription of genes involved in BCR signaling","Role of ABL in ROBO-SLIT signaling",
"Negative regulation of FGFR4 signaling","Interleukin-1 signaling","Inhibition of PKR","Centrosome maturation","MyD88-independent TLR4 cascade","Activation of TRKA receptors","Imatinib-resistant PDGFR
 mutants","Post NMDA receptor activation events","Signaling by FGFR3 point mutants in cancer","STAT5 activation downstream of FLT3 ITD mutants","Regulation of PTEN stability and activity","Interleukin
 receptor SHC signaling","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Interleukin-15 signaling","FGFR2 mutant receptor activation","Sema4D in semaphorin signaling","Mitotic Anaphase","Cyclin D a
ssociated events in G1","Late Phase of HIV Life Cycle","VEGFR2 mediated cell proliferation","ISG15 antiviral mechanism","Downstream signaling of activated FGFR4","RAS processing","Recycling pathway of
 L1","Signaling downstream of RAS mutants","Truncations of AMER1 destabilize the destruction complex","Visual phototransduction","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","IR
F3-mediated induction of type I IFN","Regulation of IFNA signaling","Assembly and cell surface presentation of NMDA receptors","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Express
ion and Degradation","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","MAP kinase activation","FCGR3A-mediated IL10 synthesis","PI3K Cascade","MyD88:MAL(TIRAP) cascade initiated on pla
sma membrane","Prolonged ERK activation events","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Regulation of TP53 Activity through Phosphorylation","
Spry regulation of FGF signaling","Loss of proteins required for interphase microtubule organization from the centrosome","TRIF(TICAM1)-mediated TLR4 signaling","Regulation of TP53 Activity through Ac
etylation","NGF-independant TRKA activation","CD163 mediating an anti-inflammatory response","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","FGFR3 mutant receptor a
ctivation","Nef and signal transduction","Activated point mutants of FGFR2","Sema4D induced cell migration and growth-cone collapse","Separation of Sister Chromatids","Transcription of the HIV genome"
,"FRS-mediated FGFR4 signaling","The phototransduction cascade","Signalling to RAS","Signaling by activated point mutants of FGFR1","Activation of AMPK downstream of NMDARs","Regulation of TP53 Degrad
ation","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","Frs2-mediated activation","Nef Mediated CD4 Down-regulation","ARMS-mediated activation","activated TAK1 m
ediates p38 MAPK activation","Loss of Nlp from mitotic centrosomes","TRAF6-mediated induction of TAK1 complex within TLR4 complex","PI5P Regulates TP53 Acetylation","RSK activation","Signaling by acti
vated point mutants of FGFR3","Ras activation upon Ca2+ influx through NMDA receptor","HIV Transcription Elongation","MAPK targets/ Nuclear events mediated by MAP kinases",Inactivation,"recovery and r
egulation of the phototransduction cascade","p38MAPK events","Tat-mediated elongation of the HIV-1 transcript","CREB phosphorylation","Activation of the AP-1 family of transcription factors","Formatio
n of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{MTOR,PASK}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{PP242,1092351-67-1,1092351671,TORKinib,PP-242,"PP 242","Torkinib (PP242)","2-(4-amino-1-isopropyl-1H-pyrazolo(3,4-d)pyrimidin-3-yl)-1H-indol-5-ol","2(4amino1isopropyl1Hpyrazolo(3,4d)pyrimidin3yl)1Hin
dol5ol",UNII-H5669VNZ7V,UNIIH5669VNZ7V,H5669VNZ7V,CHEBI:90679,2-(4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo(3,2(4Amino1(Propan2Yl)1hPyrazolo(3,4-D)pyrimidin-3-Yl)-1h-Indol-5-O,4D)pyrimidin3Yl)1hIndol5O,T2414
,S2218,Torkinib}

> <pdid>
PD010820

> <targets>
{mTOR,Autophagy,Apoptosis,Mitophagy}

> <classes>
{PI3K/Akt/mTOR,Apoptosis,Autophagy}

> <pubchem_cids>
{135565635}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -1.2935    3.7495    0.0000 C   0  0
   -1.2883    5.2495    0.0000 C   0  0
   -2.5848    6.0040    0.0000 C   0  0
   -2.5796    7.5040    0.0000 I   0  0
   -3.8864    5.2585    0.0000 C   0  0
   -3.8915    3.7585    0.0000 C   0  0
   -5.1932    3.0130    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -3.8963   -3.7531    0.0000 C   0  0
   -3.8941   -5.2539    0.0000 C   0  0
   -2.5938   -6.0017    0.0000 O   0  0
   -5.1923   -6.0070    0.0000 C   0  0
   -5.1902   -7.5070    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
    0.0000    3.0000    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14  8  1  0
 14 15  1  0
  6 16  1  0
 16 17  2  3
 17  2  1  0
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 24 25  1  0
 20 26  1  0
 26 16  1  0
 26 27  2  0
  5 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28551

> <plate>
Kinase v5-2

> <well>
M16

> <supplier_cmpd_name>
TAK-733

> <ctcr_id>
6829

> <supplier_cmpd_id>
S2617

> <smiles>
CN1C(=O)C(=C(Nc2ccc(I)cc2F)C3=C1N=CN(CC(O)CO)C3=O)F

> <pd_targets>
{MAP2K1,MAP2K2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","STE protein kinase STE7 family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","STE7 family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by NTRKs","Signaling by NTRK1 (TRKA)","Signalling to ERKs","Prolonged ERK activation events","Frs2-mediated activation"}

> <broad_targets>
{MAP2K1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{SCHEMBL1528609,CHEMBL2131626,HMS3656L03,NCGC00389376-01,NCGC0038937601,AK186819,DA-48192,DA48192,FT-0774097,FT0774097,T6692,S2617,TAK-733}

> <pdid>
PD010918

> <targets>
{MEK}

> <classes>
{MAPK}

> <pubchem_cids>
{67065878}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 36  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -6.5472    0.8772    0.0000 N   0  0
   -7.5527    1.9903    0.0000 C   0  0
   -6.8048    3.2905    0.0000 N   0  0
   -5.3371    2.9810    0.0000 C   0  0
   -4.2174    3.9803    0.0000 C   0  0
   -2.7654    3.6256    0.0000 C   0  0
   -1.7292    4.7101    0.0000 C   0  0
   -2.1503    6.1498    0.0000 N   0  0
   -3.6077    6.5049    0.0000 C   0  0
   -4.6439    5.4203    0.0000 C   0  0
   -9.0450    1.8311    0.0000 C   0  0
   -9.7512    0.5133    0.0000 C   0  0
  -11.2505    0.4669    0.0000 C   0  0
  -12.0404    1.7420    0.0000 C   0  0
  -11.3310    3.0637    0.0000 C   0  0
   -9.8317    3.1102    0.0000 C   0  0
  -13.5406    1.6986    0.0000 S   0  0
  -14.2523    0.3782    0.0000 C   0  0
  -14.3287    2.9749    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  6  1  0
 11 12  2  0
 12  3  1  0
  8 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 13  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 15 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 27 30  1  0
 30 31  1  0
 30 32  2  0
M  END
> <name>
UTKinase_V5

> <id>
28552

> <plate>
Kinase v5-2

> <well>
M18

> <supplier_cmpd_name>
Tie2 kinase inhibitor

> <ctcr_id>
3256

> <supplier_cmpd_id>
S1577

> <smiles>
COc1ccc2cc(ccc2c1)c3nc([nH]c3c4ccncc4)c5ccc(cc5)[S](C)=O

> <pd_targets>
{TEK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Tie family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XII RTKs: TIE family of angiopoietin receptors"}

> <pathway_reactome>
{"Signal Transduction","MAPK family signaling cascades","MAPK1/MAPK3 signaling","RAF/MAP kinase cascade"}

> <broad_targets>
{KDR,MAPK14}

> <broad_moa>
{"TIE tyrosine kinase inhibitor"}

> <synonyms>
{"Tie2 kinase inhibitor",948557-43-5,948557435,"Tie2 kinase-IN-1","Tie2 kinaseIN1","Tie2 kinase inhibitor 1",Tie2-IN-5,Tie2IN5,CHEMBL237352,C26H21N3O2S,"Tie-2 kinase Inhibitor","Tie2 kinase Inhibitor"
,MLS006011077,GTPL9348,SCHEMBL17835458,CHEBI:91442,DTXSID60635231,HMS3655I07,HMS3672K19,BCP,S1577}

> <pdid>
PD003231

> <targets>
{Tie-2}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{23625762}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 43  0  0  0  0            999 V2000
   -3.9504   -7.1827    0.0000 C   0  0
   -2.8628   -6.1485    0.0000 N   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 C   0  0
   -3.2175   -4.6910    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -6.6258    3.4575    0.0000 N   0  0
   -7.5055    2.2426    0.0000 C   0  0
   -6.6219    1.0305    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
    2.5987    1.5004    0.0000 N   0  0
    3.8991    0.7525    0.0000 C   0  0
    5.1969    1.5046    0.0000 C   0  0
    5.1945    3.0046    0.0000 O   0  0
    3.8943    3.7525    0.0000 C   0  0
    2.5964    3.0004    0.0000 C   0  0
   -5.3902   -6.7589    0.0000 C   0  0
   -6.4787   -7.7910    0.0000 C   0  0
   -7.9167   -7.3645    0.0000 C   0  0
   -8.2664   -5.9058    0.0000 C   0  0
   -7.1780   -4.8736    0.0000 N   0  0
   -5.7399   -5.3002    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  8  1  0
 16 11  1  0
 14 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 20  1  0
 24 25  2  0
 25 17  1  0
 12 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 26  1  0
  1 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28553

> <plate>
Kinase v5-2

> <well>
M20

> <supplier_cmpd_name>
WAY-600

> <ctcr_id>
4820

> <supplier_cmpd_id>
S2689

> <smiles>
C(N1CCC(CC1)n2ncc3c(nc(nc23)c4ccc5[nH]ccc5c4)N6CCOCC6)c7cccnc7

> <pd_targets>
{PIK3CA,MTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfami
ly"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Signaling by FGFR in disease","Generic 
Transcription Pathway","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Signaling by cytosolic FGFR1 fusion mutant
s","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{WAY-600,WAY600,1062159-35-6,1062159356,"WAY 600","pyrazolo pyrimidine, 5u",MLS006011005,CHEMBL583194,SCHEMBL5000751,BDBM35615,C28H30N8O,DTXSID00649397,HMS3656N13,BCP02897,EX-A4657,EXA4657,s2689,ZINC4
5315610,CCG-269655,CCG269655,SB16562,NCGC00346634-01,NCGC0034663401,NCGC00346634-03,NCGC0034663403,AC-28452,AC28452,SMR00470,S2689}

> <pdid>
PD010886

> <targets>
{mTOR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{25229526}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 44  0  0  0  0            999 V2000
    7.7795   -7.5156    0.0000 C   0  0
    7.7840   -6.0157    0.0000 O   0  0
    6.4870   -5.2605    0.0000 C   0  0
    5.1855   -6.0062    0.0000 O   0  0
    6.4915   -3.7597    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1884   -2.6409    0.0000 C   0  0
   -4.6234   -3.0602    0.0000 C   0  0
   -4.9781   -4.5176    0.0000 C   0  0
   -3.8933   -5.5536    0.0000 N   0  0
   -4.2452   -7.0125    0.0000 C   0  0
   -3.1582   -8.0475    0.0000 C   0  0
   -3.5078   -9.5062    0.0000 C   0  0
   -2.4194  -10.5384    0.0000 C   0  0
   -0.9813  -10.1118    0.0000 C   0  0
   -0.6316   -8.6531    0.0000 N   0  0
   -1.7201   -7.6210    0.0000 C   0  0
   -2.4537   -5.1320    0.0000 C   0  0
   -2.0990   -3.6745    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 15  1  0
 14 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
 28 36  1  0
 36 37  1  0
 37 25  1  0
 24 38  1  0
 38 21  1  0
 38 39  2  0
 39 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28554

> <plate>
Kinase v5-2

> <well>
M22

> <supplier_cmpd_name>
WYE-687

> <ctcr_id>
2047

> <supplier_cmpd_id>
S2668

> <smiles>
COC(=O)Nc1ccc(cc1)c2nc(N3CCOCC3)c4cnn(C5CCN(Cc6cccnc6)CC5)c4n2

> <pd_targets>
{PIK3CA,MTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfami
ly"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Signaling by FGFR in disease","Generic 
Transcription Pathway","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Signaling by cytosolic FGFR1 fusion mutant
s","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{YE68,BDBM35575,DTXSID40649396,WYE-687,WYE687,1062161-90-3,1062161903,"WYE 687;WYE687","WYE 687","pyrazolo pyrimidine, 9",cc-613,cc613,MLS006011004,CHEMBL561103,SCHEMBL10092310,C28H32N8O3,BCP23427,s26
68,ZINC43067855,CS-0698,CS0698,SB19262,NCGC00346636-01,NCGC0034663601,NCGC00346636-03,NCGC0034663603,AC-28453,AC28453,HY-1,HY1,S2668}

> <pdid>
PD070070

> <targets>
{mTOR}

> <classes>
{}

> <pubchem_cids>
{25229450}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    2.5617   -2.9798    0.0000 O   0  0
    1.2626   -2.2300    0.0000 C   0  0
   -0.0361   -2.9805    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -7.7988    1.4819    0.0000 Cl  0  0
   -5.2007    1.4909    0.0000 C   0  0
   -5.2060    2.9909    0.0000 F   0  0
    2.5629    0.0216    0.0000 C   0  0
    3.8632   -0.7278    0.0000 C   0  0
    5.1516    0.0428    0.0000 C   0  0
    6.4623   -0.6867    0.0000 C   0  0
    6.4859   -2.1865    0.0000 C   0  0
    5.1988   -2.9568    0.0000 C   0  0
    5.2193   -4.4575    0.0000 N   0  0
    3.9304   -5.2265    0.0000 C   0  0
    3.8107   -6.7089    0.0000 S   0  0
    2.3474   -7.0387    0.0000 C   0  0
    1.5816   -5.7490    0.0000 C   0  0
    2.5715   -4.6220    0.0000 N   0  0
    3.8881   -2.2274    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17 11  1  0
 17 18  1  0
  4 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 26  2  0
 24 31  2  0
 31 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28555

> <plate>
Kinase v5-2

> <well>
O04

> <supplier_cmpd_name>
MK-5108 (VX-689)

> <ctcr_id>
1373

> <supplier_cmpd_id>
S2770

> <smiles>
OC(=O)C1(CCC(CC1)Oc2cccc(Cl)c2F)Cc3cccc(Nc4sccn4)n3

> <pd_targets>
{AURKA,AURKC,AURKB,INCENP}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Aurora kinase (Aur) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","M Phase","Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase
","Regulation of TP53 Activity","Mitotic Anaphase","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids"}

> <broad_targets>
{AURKA,AURKB,AURKC}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{"K5108 (VX689",MK-5108,MK5108,1010085-13-8,1010085138,VX-689,VX689,"MK 5108","MK-5108 (VX-689)","MK5108 (VX689)",UNII-H8J407531S,UNIIH8J407531S,CHEMBL3600873,H8J407531S,"VX 689",MK-5198,MK5198,C22H21
ClFN3O3S,cc-619,cc619,MLS006011047,GTPL8061,SCHEMBL1501371,SCHEMBL1501374,CHEMBL3182444,EX-A093,EXA093,CHEBI:125340,T6068,S2770}

> <pdid>
PD003211

> <targets>
{"Aurora Kinase"}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{24748204}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 30  0  0  0  0            999 V2000
   11.5035   -5.2462    0.0000 C   0  0
   10.1342   -4.6338    0.0000 N   0  0
    8.8339   -5.3815    0.0000 C   0  0
    7.7422   -4.3714    0.0000 C   0  0
    8.3333   -3.0066    0.0000 C   0  0
    9.8249   -3.1660    0.0000 N   0  0
    6.2733   -4.6785    0.0000 C   0  0
    5.8050   -6.1036    0.0000 C   0  0
    4.3368   -6.4106    0.0000 C   0  0
    3.3368   -5.2925    0.0000 C   0  0
    1.8376   -5.2878    0.0000 N   0  0
    1.3788   -3.8597    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8050   -3.8675    0.0000 N   0  0
    5.2733   -3.5605    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 18  1  0
 23 24  2  0
 24 15  1  0
 13 25  1  0
 25 10  1  0
 25 26  1  0
 26  7  2  0
M  END
> <name>
UTKinase_V5

> <id>
28556

> <plate>
Kinase v5-2

> <well>
O06

> <supplier_cmpd_name>
NVP-BVU972

> <ctcr_id>
4105

> <supplier_cmpd_id>
S2761

> <smiles>
Cn1cc(cn1)c2ccc3ncc(Cc4ccc5ncccc5c4)n3n2

> <pd_targets>
{MET}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Semaphorin interactions","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{MET}

> <broad_moa>
{"MET inhibitor"}

> <synonyms>
{NVP-BVU972,NVPBVU972,1185763-69-2,1185763692,"NVP-BVU 972","NVPBVU 972",NVP-BVU-972,"6-((6-(1-methylpyrazol-4-yl)imidazo(1,2-b)pyridazin-3-yl)methyl)quinoline","6((6(1methylpyrazol4yl)imidazo(1,2b)py
ridazin3yl)methyl)quinoline",CHEMBL1738731,C20H16N6,3qti,"NVP BVU972",cc-601,cc601,MLS006010964,BVU972,SCHEMBL1659100,AOB2279,BVU-972,DTXSID40657890,T2680,S2761}

> <pdid>
PD010585

> <targets>
{c-Met,c-Met/HGFR}

> <classes>
{Protein Tyrosine Kinase,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{44206063}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    9.0946   -5.2463    0.0000 C   0  0
    9.0967   -3.7463    0.0000 O   0  0
    7.7985   -2.9932    0.0000 C   0  0
    7.7985   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -1.2991    5.2500    0.0000 O   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.8971    3.7500    0.0000 C   0  0
   -5.1962    3.0000    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
   -6.4975    3.7477    0.0000 C   0  0
   -6.5001    5.2477    0.0000 C   0  0
   -7.7954    2.9958    0.0000 O   0  0
    5.2004   -2.9933    0.0000 C   0  0
    6.4995   -3.7432    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 20 21  1  0
 21 11  2  0
 21 22  1  0
 22 23  2  0
 23  9  1  0
 23 24  1  0
 24 25  1  0
 17 26  1  0
 26 27  1  0
 26 28  1  0
  6 29  1  0
 29 30  2  0
 30  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28557

> <plate>
Kinase v5-2

> <well>
O08

> <supplier_cmpd_name>
Palomid 529

> <ctcr_id>
6126

> <supplier_cmpd_id>
S2238

> <smiles>
COc1ccc(COc2cc3OC(=O)c4cc(ccc4c3cc2OC)C(C)O)cc1

> <pd_targets>
{MTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by TP53","Regulation of TP53 Activity","Regulation of TP53 Expression a
nd Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"AKT inhibitor","mTOR inhibitor"}

> <synonyms>
{"Palomid 529",914913-88-5,914913885,P529,Palomid-529,Palomid529,"Palomid 529 (P529)","SG 00529",SG-00529,SG00529,P-529,UNII-XV9409EWG4,UNIIXV9409EWG4,RES-529,RES529,XV9409EWG4,"Palomid 529,P529",cc-5
13,cc513,MLS006011187,"Palomid 529 - P529","Palomid 529  P529",SCHEMBL290034,C22H26Cl2N2O8,CHEMBL2141712,EX-,EX,T2706,S2238}

> <pdid>
PD012744

> <targets>
{mTOR,Apoptosis}

> <classes>
{PI3K/Akt/mTOR,Apoptosis}

> <pubchem_cids>
{11998575}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    6.4870   -5.2597    0.0000 C   0  0
    6.4915   -3.7597    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.8971    3.7500    0.0000 N   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -6.4915   -3.7597    0.0000 O   0  0
   -6.4870   -5.2605    0.0000 C   0  0
   -7.7840   -6.0157    0.0000 C   0  0
   -7.7795   -7.5157    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  6  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18 11  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
 23 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 19 30  1  0
 30  9  1  0
 30 31  2  0
M  END
> <name>
UTKinase_V5

> <id>
28558

> <plate>
Kinase v5-2

> <well>
O10

> <supplier_cmpd_name>
PF-04691502

> <ctcr_id>
3302

> <supplier_cmpd_id>
S2743

> <smiles>
COc1ccc(cn1)C2=Cc3c(C)nc(N)nc3N(C4CCC(CC4)OCCO)C2=O

> <pd_targets>
{MTOR,PIK3CA,AKT1,PIK3CB,PIK3CD,PIK3CG,PIK3R1,PIK3R2,PIK3R3,PIK3R5,PIK3C2G,PIK3C2B,PI4KB}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","Atypical protein kinase group","AGC protein kinase group","Atypical protein kinase PIKK family","AGC protein kinase AKT family","Atypical protein kinase FR
AP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Lipid modifying kinases","AGC: Containing PKA",PKG,"PKC families","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bi
sphosphate 3-kinase family","Akt (Protein kinase B","PKB) family","Phosphatidylinositol-4-phosphate 3-kinase family","1-phosphatidylinositol 4-kinase family","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,Metabolism,"Immune System","Signal Transduction","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second mes
sengers","Metabolism of lipids","Cytokine Signaling in Immune system","Signaling by Receptor Tyrosine Kinases","Generic Transcription Pathway","Signaling by FGFR in disease","Phospholipid metabolism",
"Signaling by Interleukins","Signaling by Insulin receptor","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","PI Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Ins
ulin receptor signalling cascade","Regulation of TP53 Activity","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membrane","Synthesis of PIPs at the Golgi membrane","Interleukin rec
eptor SHC signaling","IRS-mediated signalling","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR,PIK3CA}

> <broad_moa>
{"mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{F0469150,PF-04691502,PF04691502,1013101-36-4,1013101364,"PF 04691502",UNII-4W39NS61KI,UNII4W39NS61KI,CHEMBL1234354,4W39NS61KI,PF-4691502,PF4691502,PubChem24348,4tv3,cc-350,cc350,MLS006010979,GTPL7936
,SCHEMBL1381425,SCHEMBL1381431,SCHEMBL1984896,SCHEMBL10092210,SCHEMBL13976989,EX-A032,EXA032,QCR-137,QCR137,H,T6251,S2743}

> <pdid>
PD010689

> <targets>
{mTOR,PI3K,Akt}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{25033539}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
   -1.2250   -6.6252    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 N   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 O   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    3.8805   -1.4410    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    2.5981    3.0000    0.0000 C   0  0
    3.8963    3.7531    0.0000 N   0  0
    3.8941    5.2539    0.0000 C   0  0
    5.1905    6.0085    0.0000 C   0  0
    5.1853    7.5085    0.0000 C   0  0
    3.8837    8.2540    0.0000 C   0  0
    2.5873    7.4995    0.0000 C   0  0
    2.5925    5.9995    0.0000 C   0  0
    3.8785    9.7548    0.0000 N   0  0
    5.1737   10.5114    0.0000 C   0  0
    5.1661   12.0114    0.0000 C   0  0
    3.8633   12.7548    0.0000 N   0  0
    3.8557   14.2548    0.0000 C   0  0
    2.5681   11.9983    0.0000 C   0  0
    2.5757   10.4983    0.0000 C   0  0
    1.2990    3.7500    0.0000 N   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -1.2636   -2.2496    0.0000 C   0  0
   -2.5801    0.0303    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 25 26  1  0
 26 20  1  0
 12 27  2  0
 27 28  1  0
 28 29  2  0
 29 10  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 31 33  1  0
 31 34  1  0
 34  5  1  0
 34  9  2  0
M  END
> <name>
UTKinase_V5

> <id>
28559

> <plate>
Kinase v5-2

> <well>
O12

> <supplier_cmpd_name>
PHA-848125

> <ctcr_id>
4045

> <supplier_cmpd_id>
S2751

> <smiles>
CNC(=O)c1nn(C)c2c3nc(Nc4ccc(cc4)N5CCN(C)CC5)ncc3CC(C)(C)c12

> <pd_targets>
{CCNH,CDK7,LCK,ABL1,EGFR,CDK2,CDK5,CDK5R1,NTRK1,WEE2,CDK1,PKMYT1,CCNB1,CCND1,CDK4,AURKA,FGFR1,CCNE1,WEE1,CCNA2,CDK9,AURKB,KIT,FLT4,NEK6,RET,MNAT1,CCNT1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","TK protein kinase group","Other protein kinase group","CMGC protein kinase CDK family","Tyrosine protein kinase Src family","Tyrosine prote
in kinase Abl family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Trk family","Other protein kinase WEE family","Other protein kinase AUR family","Tyrosine protein kinase FGFR famil
y","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","Other protein kinase NEK family","Tyrosine protein kinase Ret family","CMGC protein kinase CDK7 subfamily","CMGC prote
in kinase CDC2 subfamily","Other protein kinase WEE1","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","Other p
rotein kinases","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","WEE family","Aurora kinase (Aur) family","CDK7 subfamily","CDK9 subfamily","CDK4 subfamily"
,"CDK5 subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","Src family","Abl family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type VII RTKs: Neurotrophin rec
eptor/Trk family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor
 family","Type XIV RTKs: RET"}

> <pathway_reactome>
{Disease,"Signal Transduction","Gene expression (Transcription)","Cell Cycle","Developmental Biology","Infectious disease","Signaling by GPCR","RNA Polymerase II Transcription","Signaling by Receptor 
Tyrosine Kinases",Mitotic,"Diseases of signal transduction by growth factor receptors and second messengers","Cell Cycle Checkpoints","Nervous system development","HIV Infection","Leishmania infection
","GPCR downstream signalling","Generic Transcription Pathway","Signaling by NTRKs","Regulation of mitotic cell cycle","Mitotic G2-G2/M phases","Signaling by FGFR in disease","G2/M Checkpoints","Mitot
ic G1 phase and G1/S transition","M Phase","Signaling by KIT in disease","Signaling by VEGF","Axon guidance","Host Interactions of HIV factors","Parasite infection","G alpha (q) signalling events","Tr
anscriptional Regulation by TP53","Signaling by NTRK1 (TRKA)","APC/C-mediated degradation of cell cycle proteins","G2/M Transition","Signaling by FGFR1 in disease","HIV Life Cycle","G2/M DNA damage ch
eckpoint","G1 Phase","Mitotic Metaphase and Anaphase","Drug resistance of KIT mutants","VEGF ligand-receptor interactions","Mitotic Prophase","RET signaling","The role of Nef in HIV-1 replication and 
disease pathogenesis","Leishmania phagocytosis","Gastrin-CREB signalling pathway via PKC and MAPK","Regulation of TP53 Activity","Signalling to ERKs","Activation of APC/C and APC/C:Cdc20 mediated degr
adation of mitotic proteins","Cyclin A/B1/B2 associated events during G2/M transition","FGFR1 mutant receptor activation","Late Phase of HIV Life Cycle","Chk1/Chk2(Cds1) mediated inactivation of Cycli
n B:Cdk1 complex","Cyclin D associated events in G1","Mitotic Anaphase","Dasatinib-resistant KIT mutants","VEGF binds to VEGFR leading to receptor dimerization","Nuclear Envelope Breakdown","Nef-media
tes down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Regulation of TP53 Expression and Degradation",
"Prolonged ERK activation events","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Phosphorylation","Signaling by activated point mutants of FGFR1","Transcri
ption of the HIV genome","Separation of Sister Chromatids","Activation of NIMA Kinases NEK9",NEK6,NEK7,"Nef Mediated CD4 Down-regulation","Regulation of TP53 Degradation","ARMS-mediated activation","A
PC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","HIV Transcription Elongation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-media
ted elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{CDK2,CDK4,CDK7,NTRK1}

> <broad_moa>
{"CDK inhibitor","growth factor receptor inhibitor"}

> <synonyms>
{HA84812,"HA 84812",Milciclib,PHA-848125,PHA848125,"PHA 848125",802539-81-7,802539817,"802539 81 7","Milciclib (PHA-848125)","Milciclib (PHA848125)","Milciclib (PHA 848125)",UNII-688000M8S8,UNII688000
M8S8,"UNII 688000M8S8",MMV676602,688000M8S8,S2751}

> <pdid>
PD010683

> <targets>
{CDK,Autophagy}

> <classes>
{Cell Cycle,Autophagy,Cell Cycle/DNA Damage}

> <pubchem_cids>
{16718576}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 40  0  0  0  0            999 V2000
    9.6447   -5.0030    0.0000 F   0  0
    9.0268   -6.3698    0.0000 C   0  0
    9.9020   -7.5881    0.0000 F   0  0
   10.5195   -6.2213    0.0000 F   0  0
    7.5360   -6.5189    0.0000 C   0  0
    6.5380   -5.3991    0.0000 N   0  0
    5.1834   -6.0133    0.0000 C   0  0
    5.3139   -7.4949    0.0000 N   0  0
    6.7795   -7.8142    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1047   -0.0031    0.0000 N   0  0
   -5.8532   -1.3040    0.0000 C   0  0
   -7.3533   -1.3093    0.0000 C   0  0
   -8.0987   -2.6109    0.0000 C   0  0
   -7.3442   -3.9074    0.0000 C   0  0
   -5.8442   -3.9021    0.0000 C   0  0
   -5.0987   -2.6005    0.0000 C   0  0
   -8.0901   -5.2097    0.0000 C   0  0
   -9.5901   -5.2159    0.0000 F   0  0
   -7.3352   -6.5059    0.0000 F   0  0
   -8.8349   -6.5117    0.0000 F   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9  5  2  0
  7 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 24 27  1  0
 27 28  1  0
 27 29  1  0
 27 30  1  0
 19 31  2  0
 31 32  1  0
 32 17  1  0
 32 33  2  0
 33 14  1  0
 12 34  2  0
 34 35  1  0
 35 36  2  0
 36 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28560

> <plate>
Kinase v5-2

> <well>
O14

> <supplier_cmpd_name>
Raf265 derivative

> <ctcr_id>
6947

> <supplier_cmpd_id>
S2200

> <smiles>
FC(F)(F)c1[nH]c(nc1)c2cc(Oc3ccc4[nH]c(Nc5ccc(cc5)C(F)(F)F)nc4c3)ccn2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Raf265 derivative","RAF-265 derivative","RAF265 derivative",MLS006011049,CHEMBL3188129,SCHEMBL14601852,C23H14F6N6O,s2200,ZINC70466437,CCG-269721,CCG269721,NCGC00346577-01,NCGC0034657701,NCGC00346577
-02,NCGC0034657702,SMR004702841,X7433,1942849-27-5,1942849275,S2200}

> <pdid>
PD088423

> <targets>
{VEGFR,Raf}

> <classes>
{}

> <pubchem_cids>
{23654923}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 40  0  0  0  0            999 V2000
    2.5891   -7.5025    0.0000 C   0  0
    2.5915   -6.0025    0.0000 C   0  0
    3.8919   -5.2533    0.0000 S   0  0
    5.1900   -6.0050    0.0000 O   0  0
    3.8903   -6.7533    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 C   0  0
   -1.2947    3.7531    0.0000 O   0  0
    1.3039    3.7494    0.0000 N   0  0
    1.3070    5.2502    0.0000 C   0  0
    2.6060    6.0003    0.0000 C   0  0
    2.6060    7.5003    0.0000 C   0  0
    1.3070    8.2503    0.0000 N   0  0
    1.3070    9.7503    0.0000 C   0  0
    0.0079    7.5003    0.0000 C   0  0
    0.0079    6.0003    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.4134   -4.4924    0.0000 N   0  0
   -1.5318   -5.7059    0.0000 C   0  0
   -0.0400   -5.5491    0.0000 C   0  0
    0.8417   -6.7626    0.0000 C   0  0
    0.5701   -4.1788    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  2  0
  3  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 21 23  1  0
 23 24  1  0
 24 18  1  0
 14 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 32 34  1  0
 34 35  2  0
 35 29  1  0
 35 36  1  0
 36 12  1  0
 36 27  2  0
M  END
> <name>
UTKinase_V5

> <id>
28561

> <plate>
Kinase v5-2

> <well>
O16

> <supplier_cmpd_name>
TAK-901

> <ctcr_id>
1061

> <supplier_cmpd_id>
S2718

> <smiles>
CC[S](=O)(=O)c1cccc(c1)c2cc(C(=O)NC3CCN(C)CC3)c(C)c4[nH]c5ncc(C)cc5c24

> <pd_targets>
{AURKA,TPX2,AURKB,INCENP}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Aurora kinase (Aur) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","M Phase","Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase
","Regulation of TP53 Activity","Mitotic Anaphase","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids"}

> <broad_targets>
{AURKB}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{TAK-901,TAK901,934541-31-8,934541318,"TAK 901",UNII-DM9UIR23R7,UNIIDM9UIR23R7,DM9UIR23R7,C28H32N4O3S,cc-11,cc11,MLS006010174,SCHEMBL645679,CHEMBL3544932,DTXSID70583097,EX-A874,EXA874,HMS3656F17,TAK-9
01/TAK901/,TAK901/TAK901/,ABP000125,MFCD18782651,NSC762151,NSC803712,s2718,ZINC35310420,AKOS005266666,T2709,S2718}

> <pdid>
PD010873

> <targets>
{"Aurora Kinase"}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{16124208}

$$$$
UTKinase_V5
  SciTegic11012413002D

 45 51  0  0  0  0            999 V2000
   11.6704   -8.2801    0.0000 C   0  0
   10.3753   -7.5233    0.0000 C   0  0
   10.3822   -6.0225    0.0000 C   0  0
   11.6850   -5.2789    0.0000 O   0  0
    9.0864   -5.2653    0.0000 N   0  0
    9.0912   -3.7653    0.0000 C   0  0
    7.7945   -3.0112    0.0000 C   0  0
    6.4930   -3.7570    0.0000 N   0  0
    6.4884   -5.2570    0.0000 C   0  0
    7.7850   -6.0111    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    3.8919   -5.2533    0.0000 C   0  0
    2.5922   -6.0021    0.0000 F   0  0
    5.1900   -6.0050    0.0000 F   0  0
    3.8903   -6.7533    0.0000 F   0  0
    1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 N   0  0
    2.5981    3.0000    0.0000 C   0  0
    3.8971    3.7500    0.0000 C   0  0
    5.1961    3.0000    0.0000 C   0  0
    5.1961    1.5000    0.0000 C   0  0
    3.8971    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    6.4958    0.7496    0.0000 C   0  0
    6.4983   -0.7504    0.0000 C   0  0
    7.7985   -1.4984    0.0000 N   0  0
    9.0964   -0.7463    0.0000 C   0  0
   10.3966   -1.4942    0.0000 C   0  0
   11.6945   -0.7422    0.0000 C   0  0
   11.6921    0.7578    0.0000 C   0  0
   10.3919    1.5057    0.0000 C   0  0
    9.0940    0.7537    0.0000 C   0  0
    7.7938    1.5016    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10  5  1  0
  8 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 16 17  1  0
 17 18  1  0
 17 19  1  0
 17 20  1  0
 14 21  1  0
 21 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  2  3
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 29  1  0
 34 35  2  0
 35 21  1  0
 35 26  1  0
 32 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 39 40  1  0
 40 41  2  0
 41 42  1  0
 42 43  2  0
 43 44  1  0
 44 39  1  0
 44 45  2  0
 45 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28562

> <plate>
Kinase v5-2

> <well>
O18

> <supplier_cmpd_name>
Torin 1

> <ctcr_id>
3839

> <supplier_cmpd_id>
S2827

> <smiles>
CCC(=O)N1CCN(CC1)c2ccc(cc2C(F)(F)F)N3C(=O)C=Cc4cnc5ccc(cc5c34)c6cnc7ccccc7c6

> <pd_targets>
{PI4KB,PIK3CA,PIK3C2B,PIK3C3,PIK3CD,PIK3R1,PRKDC,MTOR,PIK3C2A,CDC42BPA,PIK3CG,MLST8,RPTOR,MAPKAP1,RICTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","AGC protein kinase group","Atypical protein kinase PIKK family","AGC protein kinase DMPK family","Atypical protein kinase F
RAP subfamily","AGC protein kinase GEK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,"AGC: Containing PKA",PKG,"PKC families","1-phosphatidylinositol 4-kinase family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase fam
ily","Phosphatidylinositol-4-phosphate 3-kinase family","Phosphatidylinositol 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","DMPK family","Other PIKK family kinases"
,"FRAP subfamily","GEK subfamily"}

> <pathway_reactome>
{Metabolism,Disease,"Signal Transduction","Immune System","Gene expression (Transcription)","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second messengers","S
ignaling by Receptor Tyrosine Kinases","Innate Immune System","RNA Polymerase II Transcription","Phospholipid metabolism","Signaling by FGFR in disease","Signaling by Insulin receptor","Cytosolic sens
ors of pathogen-associated DNA","Generic Transcription Pathway","PI Metabolism","Signaling by FGFR1 in disease","Insulin receptor signalling cascade","STING mediated induction of host immune responses
","Transcriptional Regulation by TP53","Synthesis of PIPs at the Golgi membrane","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membrane","IRS-mediated signalling","IRF3-mediated 
induction of type I IFN","Regulation of TP53 Activity","Synthesis of PIPs at the early endosome membrane","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","Regulation of TP53 Expression an
d Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{"Torin 1",1222998-36-8,1222998368,Torin-1,Torin1,CHEMBL1256459,CHEBI:84327,cc-274,cc274,MLS003230943,GTPL8004,SCHEMBL7919574,DTXSID40678621,EX-A397,EXA397,C35H28F3N5O2,HMS3265O03,HMS3265O04,HMS3265P0
3,HMS3265P04,AOB87112,BCP02504,ABP000350,BDBM50328584,MFCD18782653,s2827,T6045,S2827}

> <pdid>
PD012797

> <targets>
{mTOR,Autophagy}

> <classes>
{PI3K/Akt/mTOR,Autophagy}

> <pubchem_cids>
{49836027}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0875    3.7680    0.0000 O   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Br  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 16 18  2  0
 18 11  1  0
  9 19  2  0
 19  5  1  0
 19 20  1  0
 20 21  2  0
 21  3  1  0
 21 22  1  0
 22 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28563

> <plate>
Kinase v5-2

> <well>
O20

> <supplier_cmpd_name>
WHI-P154

> <ctcr_id>
1254

> <supplier_cmpd_id>
S2867

> <smiles>
COc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1OC

> <pd_targets>
{EGFR,JAK1,JAK3,JAK2,ABCG2,ABCB1}

> <pathway_gtopdb>
{Enzyme,Transporter,Kinase,"Primary active transporter","Protein Kinase","ATP-binding cassette","TK protein kinase group","ABCG subfamily","ABCB subfamily","Tyrosine protein kinase EGFR family","Tyros
ine protein kinase JakA family"}

> <pathway_chembl>
{Receptors,Transporters,"Catalytic receptors","ATP-binding cassette transporter family","Receptor kinases","ABCG subfamily","ABCB subfamily","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","N
on-receptor tyrosine kinases (nRTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Cell Cycle",Metabolism,"Signaling by GPCR","Cytokine Signaling in Immune system",Mitotic,"Abacavir transport and metabolism","GPCR downstream signalling","Inter
feron Signaling","Signaling by Interleukins","Mitotic G1 phase and G1/S transition","Abacavir transmembrane transport","G alpha (q) signalling events","Antiviral mechanism by IFN-stimulated genes","In
terleukin-2 family signaling","G1 Phase","Gastrin-CREB signalling pathway via PKC and MAPK","ISG15 antiviral mechanism","Interleukin-15 signaling","Cyclin D associated events in G1","EGFR Transactivat
ion by Gastrin"}

> <broad_targets>
{EGFR,JAK1,JAK2,JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{HIP15,WHI-P154,WHIP154,211555-04-3,211555043,"WHI-P 154","WHIP 154","jak3 inhibitor ii","2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol","2Bromo4((6,7dimethoxyquinazolin4yl)amino)phenol","2-br
omo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol","2bromo4((6,7dimethoxyquinazolin4yl)amino)phenol","2-Bromo-4-((6,7-dimethoxy-4-quinazolinyl)amino)phenol","2Bromo4((6,7dimethoxy4quinazolinyl)amino)p
henol",C16H14BrN3O3,CHEMBL473773,T1985,"EMD 420104",S2867,420104}

> <pdid>
PD010538

> <targets>
{JAK,EGFR}

> <classes>
{JAK/STAT}

> <pubchem_cids>
{3795}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    3.8976   -0.7553    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -3.8976   -0.7554    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 N   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -7.7905   -6.0071    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -7.7897   -3.0041    0.0000 N   0  0
   -7.7876   -1.5032    0.0000 C   0  0
   -6.4873   -0.7555    0.0000 O   0  0
   -9.0858   -0.7502    0.0000 C   0  0
   -9.0859    0.7498    0.0000 C   0  0
  -10.3850    1.4998    0.0000 C   0  0
  -11.6840    0.7498    0.0000 C   0  0
  -12.9831    1.4998    0.0000 O   0  0
  -11.6840   -0.7502    0.0000 C   0  0
  -10.3850   -1.5002    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  8 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 22  1  0
 18 29  2  0
 29 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28564

> <plate>
Kinase v5-2

> <well>
O22

> <supplier_cmpd_name>
ZM 336372

> <ctcr_id>
6033

> <supplier_cmpd_id>
S2720

> <smiles>
CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2

> <pd_targets>
{ALOX15,KDM4E,MAPT,IMPA1,CYP3A4,MAPK14,RAF1,RORC,ALDH1A1,LEF,TP53,BRAF,LCK,HSD17B10,CYP1A2,MAPK11,HPGD}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Transcription factor",Oxidoreductase,Eraser,Hydrolase,"Cytochrome P450",Kinase,"Nuclear receptor",Protease,"Lysine demethylase","Cytochrome P4
50 family 3","Protein Kinase","Nuclear hormone receptor subfamily 1","Metallo protease","Cytochrome P450 family 1","Jumonji domain-containing","Cytochrome P450 family 3A","CMGC protein kinase group","
TKL protein kinase group","Nuclear hormone receptor subfamily 1 group F","Metallo protease MAE clan","TK protein kinase group","Cytochrome P450 family 1A","Cytochrome P450 3A4","CMGC protein kinase MA
PK family","TKL protein kinase RAF family","Nuclear hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Tyrosine protein kinase Src family","Cytochrome P450 1A1","CMGC protei
n kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Eicosanoid turnover","Chromatin modifying enzymes","Inositol phosphate turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","Catalytic receptors","Nuclear hormone receptors",Lipoxyge
nases,"1.14.11.- Histone demethylases","Inositol monophosphatase","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","1F. Retinoic acid-related orphans","CYP1 family","Pr
ostaglandin synthases","Mitogen-activated protein kinases (MAP kinases)","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","p38 subfamily","RAF family","Non-receptor tyrosine kinases (nRTKs)","Src fam
ily"}

> <pathway_reactome>
{Metabolism,"Neuronal System","Immune System","Signal Transduction","Gene expression (Transcription)",Disease,"Cell Cycle","Metabolism of lipids","Transmission across Chemical Synapses","Inositol phos
phate metabolism","Innate Immune System","MAPK family signaling cascades","RNA Polymerase II Transcription","Biological oxidations","Infectious disease","Cell Cycle Checkpoints","Signaling by Receptor
 Tyrosine Kinases","Metabolism of amino acids and derivatives","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotransmitter receptors and postsynaptic signal transmission","Synthesis 
of IP2",IP,"and Ins in the cytosol","Toll-like Receptor Cascades","MAPK1/MAPK3 signaling","Generic Transcription Pathway","Phase I - Functionalization of compounds","Uptake and actions of bacterial to
xins","G1/S DNA Damage Checkpoints","Signaling by NTRKs","HIV Infection","Branched-chain amino acid catabolism","Biosynthesis of DPA-derived SPMs","Activation of NMDA receptors and postsynaptic events
","Biosynthesis of DHA-derived SPMs","Toll Like Receptor 5 (TLR5) Cascade","RAF/MAP kinase cascade","Transcriptional regulation by RUNX3","Ethanol oxidation","Uptake and function of anthrax toxins","p
53-Dependent G1/S DNA damage checkpoint","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Cytochrome P450 - arranged by substrate type","Biosynthesis of DPAn-3 SPMs","Post NMDA receptor
 activation events","Biosynthesis of maresins","MyD88 cascade initiated on plasma membrane","Negative regulation of MAPK pathway","RUNX3 Regulates Immune Response and Cell Migration","p53-Dependent G1
 DNA Damage Response","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis",Xenobiotics,"Biosynthesis of D-series resolvins","Biosynthesis of DPAn-3-derived protectins a
nd resolvins","Activation of AMPK downstream of NMDARs","Biosynthesis of maresin-like SPMs","MAP kinase activation","Negative feedback regulation of MAPK pathway","Stabilization of p53","Prolonged ERK
 activation events","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAPK targets/ N
uclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","ARMS-mediated activation","Nef Mediated CD4 Down-regulation","Activation of the AP-1 family of transcription f
actors"}

> <broad_targets>
{BRAF,LCK,MAPK14,RAF1}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{"ZM 336372",208260-29-1,208260291,ZM336372,ZM-336372,3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide,3(dimethylamino)N(3(4hydroxybenzamido)4methylphenyl)benzamide,N-(5-(3-Dimethy
laminobenzamido)-2-methylphenyl)-4-hydroxybenzamide,N(5(3Dimethylaminobenzamido)2methylphenyl)4hydroxybenzamide,CHEMBL186526,3-(dimethylamino)-N-(3-((4-hydroxybenzoyl)amino)-4-,3(dimethylamino)N(3((4h
ydroxybenzoyl)amino)4,T1851,1321,S2720,EI-298}

> <pdid>
PD010695

> <targets>
{Raf,cRAF}

> <classes>
{MAPK}

> <pubchem_cids>
{5730}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 36  0  0  0  0            999 V2000
   14.6983    2.6997    0.0000 C   0  0
   13.2297    2.3946    0.0000 C   0  0
   12.7595    0.9701    0.0000 N   0  0
   13.7582   -0.1492    0.0000 C   0  0
   15.2268    0.1560    0.0000 C   0  0
   15.6969    1.5804    0.0000 N   0  0
   11.2906    0.6626    0.0000 C   0  0
   10.2903    1.7803    0.0000 C   0  0
    8.8221    1.4729    0.0000 C   0  0
    8.3542    0.0477    0.0000 C   0  0
    9.3546   -1.0701    0.0000 C   0  0
   10.8228   -0.7626    0.0000 C   0  0
    6.8858   -0.2623    0.0000 C   0  0
    5.8837    0.8539    0.0000 C   0  0
    4.4160    0.5441    0.0000 N   0  0
    3.9504   -0.8818    0.0000 C   0  0
    4.9525   -1.9980    0.0000 N   0  0
    6.4202   -1.6882    0.0000 C   0  0
    4.2013   -3.2954    0.0000 N   0  0
    2.7345   -2.9814    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  3  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 10 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 13  2  0
 17 19  1  0
 19 20  2  0
 20 21  1  0
 21 16  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 22  1  0
 31 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28565

> <plate>
Kinase v5-2

> <well>
B03

> <supplier_cmpd_name>
LDN193189

> <ctcr_id>
69

> <supplier_cmpd_id>
S2618

> <smiles>
C1CN(CCN1)c2ccc(cc2)c3cnc4n(c3)ncc4c5ccnc6ccccc56

> <pd_targets>
{KDR,ACVRL1,PRKAB1,TGFBR2,BMPR1A,BMPR2,TGFBR1,ACVR1B,ACVR1,BMPR1B,BMP4}

> <pathway_gtopdb>
{Enzyme,Kinase,Protease,"Protein Kinase","Protein kinase regulatory subunit","Metallo protease","TK protein kinase group","TKL protein kinase group","Metallo protease MAM clan","Tyrosine protein kinas
e VEGFR family","TKL protein kinase STKR family","Metallo protease M12A subfamily","TKL protein kinase STKR Type 1 subfamily","TKL protein kinase STKR Type 2 subfamily","TKL protein kinase STKR1"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","CAMK-like (CA
MKL) family","Receptor tyrosine kinases (RTKs)","Receptor serine/threonine kinase (RSTK) family","AMPK subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type I rece
ptor serine/threonine kinases","Type II receptor serine/threonine kinases"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Disease,"Developmental Biology","Extracellular matrix organization","Signaling by Receptor Tyrosine Kinases","Signaling by TGFB family members"
,"RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by NODAL","Elastic fibre formation","Signaling by VEGF","Signaling by B
MP","Generic Transcription Pathway","Signaling by TGF-beta Receptor Complex in Cancer","Regulation of signaling by NODAL","Molecules associated with elastic fibres","VEGFA-VEGFR2 Pathway","Transcripti
onal Regulation by TP53","Loss of Function of SMAD2/3 in Cancer","VEGFR2 mediated cell proliferation","Regulation of TP53 Activity","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Regulation of TP5
3 Activity through Phosphorylation"}

> <broad_targets>
{ACVR1,BMPR1A}

> <broad_moa>
{"bone morphogenic protein inhibitor"}

> <synonyms>
{1062368-24-4,1062368244,LDN193189,LDN-193189,"4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)quinoline","4(6(4(piperazin1yl)phenyl)pyrazolo(1,5a)pyrimidin3yl)quinoline",UNII-W69H5YQU9O,
UNIIW69H5YQU9O,"LDN 193189","1062368-24-4 (free base)","1062368244 (free base)",W69H5YQU9O,CHEMBL513147,4-(6-(4-Piperazin-1-Ylphenyl)pyrazolo(1,4(6(4Piperazin1Ylphenyl)pyrazolo(1,5-A)pyrimidin-3-Y,5A)
pyrimidin3Y,T1935,S2618}

> <pdid>
PD013013

> <targets>
{TGF-beta/Smad}

> <classes>
{}

> <pubchem_cids>
{25195294}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    0.1101  -10.6547    0.0000 O   0  0
   -0.4306   -9.2556    0.0000 C   0  0
   -1.9127   -9.0248    0.0000 O   0  0
    0.5116   -8.0874    0.0000 C   0  0
    1.9941   -8.3161    0.0000 C   0  0
    2.9334   -7.1466    0.0000 C   0  0
    2.3903   -5.7483    0.0000 C   0  0
    3.3277   -4.5763    0.0000 N   0  0
    2.7822   -3.1780    0.0000 C   0  0
    3.7175   -2.0053    0.0000 N   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 N   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -3.1695   -0.6090    0.0000 C   0  0
   -3.7175   -2.0053    0.0000 C   0  0
   -5.2007   -2.2289    0.0000 Cl  0  0
   -2.7822   -3.1781    0.0000 C   0  0
   -1.2990   -2.9545    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 N   0  0
   -2.5248    2.0134    0.0000 C   0  0
   -2.2261    3.4874    0.0000 C   0  0
   -0.8038    3.9639    0.0000 F   0  0
   -3.3495    4.4814    0.0000 C   0  0
   -4.7720    4.0055    0.0000 C   0  0
   -5.0711    2.5356    0.0000 C   0  0
   -3.9477    1.5416    0.0000 C   0  0
   -4.2488    0.0721    0.0000 F   0  0
    0.9077   -5.5197    0.0000 C   0  0
   -0.0316   -6.6892    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  3
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 18 20  2  0
 20 21  1  0
 21 22  2  0
 22 16  1  0
 22 23  1  0
 23 12  1  0
 23 24  2  0
 24  9  1  0
 15 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 25  1  0
 31 32  1  0
  7 33  1  0
 33 34  2  0
 34  4  1  0
M  END
> <name>
UTKinase_V5

> <id>
28566

> <plate>
Kinase v5-2

> <well>
B05

> <supplier_cmpd_name>
MLN8054

> <ctcr_id>
2454

> <supplier_cmpd_id>
S1100

> <smiles>
OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4c3n2)c5c(F)cccc5F)cc1

> <pd_targets>
{AURKA,BTK,CLK3,SRC,EPHA4,PTK2,FGFR1,AURKB,FGFR3,FLT4,LYN,TIE1,NTRK3,AXL,EPHB3,ABL1,EGFR,FYN,EPHA3,EPHA5,ROS1,TYRO3,EPHA7,FLT1,MERTK,BLK,EPHB1,LCK,PDGFRA,EPHA1,PLK1,ABL2,FGFR2,PLK4,STK17A,IRAK3,EPHA6,
RPS6KA1,CSNK2A1,CHEK2,YES1,CLK2,AURKC,TEC,HCK,STK17B,BMX,STK10,TNK1,GRK5,CSK,MAPKAPK5,DDR1,EPHB4,FER,PLK3,TEK,EPHA2,FLT3,DAPK2,PTK2B,SIK1,KDR,GABRA1,FGR,MELK,MKNK2,PDPK1,CLK4,PAK1}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Ligand-gated ion channel","Protein Kinase","GABA-A receptor","Other protein kinase group","TK protein kinase group","CMGC protein kinase group","CAMK protein kinase group
","TKL protein kinase group","AGC protein kinase group","STE protein kinase group","Other protein kinase AUR family","Tyrosine protein kinase Tec family","CMGC protein kinase CLK family","Tyrosine pro
tein kinase Src family","Tyrosine protein kinase Eph family","Tyrosine protein kinase Fak family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase 
Tie family","Tyrosine protein kinase Trk family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Abl family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Sev family","T
yrosine protein kinase PDGFR family","Other protein kinase PLK family","CAMK protein kinase DAPK family","TKL protein kinase IRAK family","AGC protein kinase RSK family","Other protein kinase CK2 fami
ly","CAMK protein kinase RAD53 family","STE protein kinase STE20 family","Tyrosine protein kinase Ack family","AGC protein kinase GRK family","Tyrosine protein kinase Csk family","CAMK protein kinase 
MAPKAPK family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Fer family","CAMK protein kinase CAMK1 family","AGC protein kinase PDK1 subfamily","Tyrosine protein kinase SrcA","AGC pro
tein kinase RSK subfamily","STE protein kinase SLK subfamily","AGC protein kinase GRK subfamily","CAMK protein kinase MAPKAPK subfamily","CAMK protein kinase QIK subfamily","CAMK protein kinase MELK s
ubfamily","CAMK protein kinase MNK subfamily","STE protein kinase PAKA subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Kinases (EC 2.7.x.x)","Ligand-gated ion channels","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-
dependent protein kinases","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","GABA<sub>A</sub> receptors","Other protein kinases","TK: Tyros
ine kinase","CLK family","Death-associated kinase (DAPK) family","TKL: Tyrosine kinase-like","RSK family","CAMK-like (CAMKL) family","STE20 family","G protein-coupled receptor kinases (GRKs)","MAPK-Ac
tivated Protein Kinase (MAPKAPK) family","PDK1 family","Aurora kinase (Aur) family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Polo-like kinase (PLK) family","Interleu
kin-1 receptor-associated kinase (IRAK) family","RSK subfamily","Casein kinase 2 (CK2) family","CHK1 subfamily","SLK subfamily","GRK4 subfamily","MAPKAPK subfamily","QIK subfamily","MELK subfamily","M
KN subfamily","PAKA subfamily","Tec family","Src family","Type XIII RTKs: Ephrin receptor family","Fak family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type IV RTKs: VEGF (vascul
ar endothelial growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Type VII RTKs: Neurotrophin receptor/Trk family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) rec
eptor family","Abl family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XVII RTKs: ROS receptors","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Ack family","Csk family
","Type XVI RTKs: DDR (collagen receptor) family","Fer family"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,"Signal Transduction","Developmental Biology","Cell Cycle",Hemostasis,"Immune System",Metabolism,"Extracellular matrix organization","Programmed Cell Death",
"Circadian Clock","Neuronal System","RNA Polymerase II Transcription","Infectious disease","Signaling by Receptor Tyrosine Kinases","Nervous system development","Diseases of signal transduction by gro
wth factor receptors and second messengers",Mitotic,"Signaling by GPCR","Cell surface interactions at the vascular wall","Innate Immune System","Cytokine Signaling in Immune system","Metabolism of lip
ids","Non-integrin membrane-ECM interactions","MAPK family signaling cascades",Apoptosis,"Transmission across Chemical Synapses","Generic Transcription Pathway","Leishmania infection","Signaling by NT
RKs","Axon guidance","Signaling by FGFR in disease","M Phase","Signaling by VEGF","GPCR downstream signalling","HIV Infection","Signaling by PDGFR in disease","Mitotic G2-G2/M phases","Toll-like Recep
tor Cascades","Signaling by Interleukins","Phospholipid metabolism","Neutrophil degranulation","Oncogenic MAPK signaling","Signaling by SCF-KIT","MAPK1/MAPK3 signaling","Signaling by Insulin receptor"
,"Caspase activation via extrinsic apoptotic signalling pathway","Neurotransmitter receptors and postsynaptic signal transmission","Transcriptional Regulation by TP53","Parasite infection","Signaling 
by NTRK1 (TRKA)","EPH-Ephrin signaling","Signaling by FGFR1 in disease","Mitotic Metaphase and Anaphase","Signaling by FGFR3 in disease","VEGF ligand-receptor interactions","Leishmania parasite growth
 and survival","Signaling by NTRK3 (TRKC)","VEGFA-VEGFR2 Pathway","G alpha (q) signalling events","Host Interactions of HIV factors","Transcriptional regulation by RUNX1","Drug resistance of PDGFR mut
ants","G2/M Transition","Signaling by ROBO receptors","Signaling by FGFR2 in disease","Toll Like Receptor 2 (TLR2) Cascade","Toll Like Receptor 5 (TLR5) Cascade",Interleukin-3,"Interleukin-5 and GM-CS
F signaling","PI Metabolism","Signaling by RAS mutants","RAF/MAP kinase cascade","Insulin receptor signalling cascade","Caspase activation via Dependence Receptors in the absence of ligand","Interleuk
in-2 family signaling","GABA receptor activation","Regulation of TP53 Activity","Leishmania phagocytosis","Signalling to ERKs","EPHA-mediated growth cone collapse","FGFR1 mutant receptor activation","
Mitotic Anaphase","Signaling by FGFR3 point mutants in cancer","VEGF binds to VEGFR leading to receptor dimerization","Anti-inflammatory response favouring Leishmania parasite infection","Activated NT
RK3 signals through PI3K","EPHB-mediated forward signaling","Gastrin-CREB signalling pathway via PKC and MAPK","The role of Nef in HIV-1 replication and disease pathogenesis","RUNX1 regulates transcri
ption of genes involved in BCR signaling","Imatinib-resistant PDGFR mutants","Centrosome maturation","Role of ABL in ROBO-SLIT signaling","FGFR2 mutant receptor activation","Toll Like Receptor TLR6:TL
R2 Cascade","MyD88 cascade initiated on plasma membrane","Synthesis of PIPs at the plasma membrane","Signaling downstream of RAS mutants","IRS-mediated signalling","Interleukin-2 signaling","VEGFR2 me
diated cell proliferation","Regulation of TP53 Activity through Phosphorylation","FCGR3A-mediated phagocytosis","Signalling to RAS","Signaling by activated point mutants of FGFR1","Separation of Siste
r Chromatids","FGFR3 mutant receptor activation","FCGR3A-mediated IL10 synthesis","EGFR Transactivation by Gastrin","Nef and signal transduction","Nef-mediates down modulation of cell surface receptor
s by recruiting them to clathrin adapters","Loss of proteins required for interphase microtubule organization from the centrosome","Activated point mutants of FGFR2","MyD88:MAL(TIRAP) cascade initiate
d on plasma membrane","MAP kinase activation","Regulation of TP53 Expression and Degradation","PI3K Cascade","p38MAPK events","Signaling by activated point mutants of FGFR3","Nef Mediated CD4 Down-reg
ulation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","CREB phosphorylation"}

> <broad_targets>
{AURKA}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{NCGC00346488-01,NCGC0034648801,NCGC00346488-06,NCGC0034648806,MLN8054,869363-13-3,869363133,MLN-8054,"MLN 8054",UNII-BX854EHD63,UNIIBX854EHD63,BX854EHD63,CHEMBL259084,ZZL,Kinome_1204,Kinome1204,Kinom
e-1204,"Kinome 1204",cc-475,cc475,MLS006011043,C25H15ClF2N4O2,SCHEMBL621589,GTPL5696,BDBM31093,CHEBI:91366,DTXSID10235987,cid_11712649,cid11712649,cid-11712649,"cid 11712649",HMS3265K23,T6315,S1100}

> <pdid>
PD011139

> <targets>
{"Aurora Kinase"}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{11712649}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 N   0  0
   -3.9021   -3.7405    0.0000 C   0  0
   -5.2008   -2.9882    0.0000 N   0  0
   -6.5020   -3.7360    0.0000 C   0  0
   -6.5021   -5.2361    0.0000 C   0  0
   -7.8011   -5.9861    0.0000 C   0  0
   -9.1002   -5.2361    0.0000 C   0  0
   -9.1002   -3.7361    0.0000 C   0  0
   -7.8011   -2.9861    0.0000 C   0  0
   -7.8043   -1.4852    0.0000 O   0  0
   -9.1044   -0.7371    0.0000 C   0  0
  -10.3999   -5.9865    0.0000 N   0  0
  -10.4023   -7.4865    0.0000 C   0  0
  -11.7026   -8.2345    0.0000 C   0  0
  -13.0004   -7.4824    0.0000 O   0  0
  -12.9980   -5.9824    0.0000 C   0  0
  -11.6978   -5.2345    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 N   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0127   -6.0039    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 21 22  1  0
 22 23  1  0
 19 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 14 30  2  0
 30 31  1  0
 31 32  2  0
 32 12  1  0
 32 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28567

> <plate>
Kinase v5-2

> <well>
B07

> <supplier_cmpd_name>
NVP-TAE226

> <ctcr_id>
479

> <supplier_cmpd_id>
S2820

> <smiles>
CNC(=O)c1ccccc1Nc2nc(Nc3ccc(cc3OC)N4CCOCC4)ncc2Cl

> <pd_targets>
{MAPK9,FLT3,MKNK2,PRKCG,BTK,MAP4K5,AURKA,MAPK10,MST1R,LTK,RPS6KB1,DYRK1A,CHEK1,DYRK1B,LCK,ALK,INSR,BRSK1,MAPK14,CLK2,CAMKK2,STK17A,TNK2,PTK2,AURKB,SIK2,IRAK1,ITK,HIPK2,ERBB4,DCLK1,CDC7,HIPK4,MARK4,PLK
4,PRKG1,CSNK2A1,PTK2B,PRKD2,PDGFRB,ROS1,MINK1,DAPK3,IGF1R,NEK2,FLT1,CLK4,SRPK1,CDK5,ERBB2,TSSK1B,CDK1,CDK7,SLK,FGFR3,PLK1,MAP3K10,TBK1,LIMK1,CDK2,IRAK4,MAPK1,FGFR1,EGFR,MAPK8,PRKD3,CHEK2,DYRK4,CAMK2D,
FER,CSF1R,LRRK2,TAOK1,PIM3,SYK,JAK2,PRKAA1,RET,MAP2K2,RPS6KA3,PLK3,HCK,SRMS,CSNK1D,FES,NEK4,MET,PAK4,PTK6,DYRK3,MELK,CAMK2B,PDPK1,CAMK2G,FRK,PHKG2,MARK3,KDR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","TK protein kinase group","CAMK protein kinase group","AGC protein kinase group","STE protein kinase group","Other protein kinase group","TK
L protein kinase group","CK1 protein kinase group","CMGC protein kinase MAPK family","Tyrosine protein kinase PDGFR family","CAMK protein kinase MAPKAPK family","AGC protein kinase PKC family","Tyrosi
ne protein kinase Tec family","STE protein kinase STE20 family","Other protein kinase AUR family","Tyrosine protein kinase Met family","Tyrosine protein kinase Alk family","AGC protein kinase RSK fami
ly","CMGC protein kinase DYRK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Src family","TKL protein kinase STKR family","Tyrosine protein kinase InsR family","CMGC protein kinas
e CLK family","Other protein kinase CAMKK family","CAMK protein kinase DAPK family","Tyrosine protein kinase Ack family","Tyrosine protein kinase Fak family","TKL protein kinase IRAK family","Tyrosine
 protein kinase EGFR family","CAMK protein kinase DCAMK1 family","Other protein kinase CDC7 family","Other protein kinase PLK family","AGC protein kinase PKG family","Other protein kinase CK2 family",
"CAMK protein kinase PKD family","Tyrosine protein kinase Sev family","Other protein kinase NEK family","Tyrosine protein kinase VEGFR family","CMGC protein kinase SRPK family","CMGC protein kinase CD
K family","CAMK protein kinase TSSK family","Tyrosine protein kinase FGFR family","TKL protein kinase MLK family","Other protein kinase IKK family","TKL protein kinase LISK family","CAMK protein kinas
e RAD53 family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase Fer family","TKL protein kinase LRRK family","CAMK protein kinase PIM family","Tyrosine protein kinase Syk family","Tyrosine
 protein kinase JakA family","Tyrosine protein kinase Ret family","STE protein kinase STE7 family","CK1 protein kinase CK1 family","AGC protein kinase PDK1 subfamily","CAMK protein kinase PHk family",
"CMGC protein kinase JNK subfamily","CAMK protein kinase MNK subfamily","AGC protein kinase PKC alpha subfamily","STE protein kinase KHS subfamily","AGC protein kinase p70 subfamily","CMGC protein kin
ase Dyrk1 subfamily","CAMK protein kinase CHK1 subfamily","TKL protein kinase STKR Type 1 subfamily","CAMK protein kinase BRSK subfamily","CMGC protein kinase p38 subfamily","Other protein kinase Meta
 subfamily","CAMK protein kinase QIK subfamily","CMGC protein kinase HIPK subfamily","CAMK protein kinase MARK subfamily","STE protein kinase MSN subfamily","CMGC protein kinase CDK5 subfamily","CMGC 
protein kinase CDC2 subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase SLK subfamily","TKL protein kinase MLK subfamily","TKL protein kinase LIMK subfamily","CMGC protein kinase ERK1"
,"STE protein kinase TAO subfamily","CAMK protein kinase AMPK subfamily","AGC protein kinase RSK subfamily","Tyrosine protein kinase Srm","STE protein kinase PAKB subfamily","CMGC protein kinase Dyrk2
 subfamily","CAMK protein kinase MELK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing
 PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","MAPK-Activ
ated Protein Kinase (MAPKAPK) family","Protein kinase C (PKC) family","STE20 family","Other protein kinases","RSK family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family"
,"CAMK-like (CAMKL) family","CLK family","Death-associated kinase (DAPK) family","TKL: Tyrosine kinase-like","DCAMKL family","Protein kinase G (PKG) family","Protein kinase D (PKD) family","SRPK famil
y","Cyclin-dependent kinase (CDK) family","Testis specific kinase (TSSK) family","CAMK2 family","PIM family","STE7 family","Casein kinase 1 (CK1) family","PDK1 family","Phosphorylase kinase (PHK) fami
ly","JNK subfamily","Receptor tyrosine kinases (RTKs)","MKN subfamily","Alpha subfamily","Non-receptor tyrosine kinases (nRTKs)","KHS subfamily","Aurora kinase (Aur) family","p70 subfamily","Dyrk1 sub
family","CHK1 subfamily","BRSK subfamily","p38 subfamily","CAMKK family","QIK subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","HIPK subfamily","CDC7 family","MARK subfamily","Polo-
like kinase (PLK) family","Casein kinase 2 (CK2) family","MSN subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","CDK5 subfamily","CDK1 subfamily","CDK7 subfamily","SLK subfamily
","Mixed Lineage Kinase (MLK) family","IKK family","LIM domain kinase (LISK) family","ERK subfamily","Leucine-rich repeat kinase (LRRK) family","TAO subfamily","AMPK subfamily","RSK subfamily","PAKB s
ubfamily","Dyrk2 subfamily","MELK subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Tec family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XIX RTKs: Leukocyte
 tyrosine kinase (LTK) receptor family","Src family","Type II RTKs: Insulin receptor family","Meta subfamily","Ack family","Fak family","Type I RTKs: ErbB (epidermal growth factor) receptor family","T
ype XVII RTKs: ROS receptors","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","MLK subfamily","LIMK subfamily","
Fer family","Syk family","Janus kinase (JakA) family","Type XIV RTKs: RET"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Neuronal System",Disease,"Gene expression (Transcription)","Cell Cycle","DNA Repair","Organelle biogenesis and maintenance",Hemostasis,Metabolism,"Cellular resp
onses to external stimuli","Programmed Cell Death","Developmental Biology","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Transmission across Chemical Synapses","Infectious disease",
"RNA Polymerase II Transcription","MTOR signalling",Mitotic,"DNA Double-Strand Break Repair","Intracellular signaling by second messengers","Adaptive Immune System","Cilium Assembly","Platelet homeost
asis","Cytokine Signaling in Immune system","Metabolism of lipids","Cellular responses to stress",Apoptosis,"Nervous system development","Diseases of signal transduction by growth factor receptors and
 second messengers","Signaling by GPCR","Signaling by Non-Receptor Tyrosine Kinases","Metabolism of carbohydrates","Toll-like Receptor Cascades","Signaling by Insulin receptor","Neurotransmitter recep
tors and postsynaptic signal transmission","Leishmania infection","Generic Transcription Pathway","Signaling by MST1","mTORC1-mediated signalling","Mitotic G1 phase and G1/S transition","Homology Dire
cted Repair","HIV Infection","PIP3 activates AKT signaling","M Phase","TCR signaling","Anchoring of the basal body to the plasma membrane","Mitotic G2-G2/M phases","Nitric oxide stimulates guanylate c
yclase","Signaling by Interleukins","Sphingolipid metabolism","Cellular Senescence","Caspase activation via extrinsic apoptotic signalling pathway","Signaling by Type 1 Insulin-like Growth Factor 1 Re
ceptor (IGF1R)","Regulation of mitotic cell cycle","Signaling by VEGF","Axon guidance","Signaling by FGFR in disease","GPCR downstream signalling","Signaling by SCF-KIT","Signaling by PTK6","Signaling
 by NTRKs","Glycogen metabolism","Oncogenic MAPK signaling","Toll Like Receptor 5 (TLR5) Cascade","Insulin receptor signalling cascade","Glutamate binding","activation of AMPA receptors and synaptic p
lasticity","Parasite infection","Transcriptional Regulation by TP53","G0 and Early G1","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Host Interactions of HIV factors",
"Negative regulation of the PI3K/AKT network","Activation of NMDA receptors and postsynaptic events","Mitotic Metaphase and Anaphase","Generation of second messenger molecules","G1/S Transition","G2/M
 Transition","cGMP effects","Interleukin-2 family signaling","Sphingolipid de novo biosynthesis","Oxidative Stress Induced Senescence","Caspase activation via Dependence Receptors in the absence of li
gand","IGF1R signaling cascade","APC/C-mediated degradation of cell cycle proteins","VEGF ligand-receptor interactions","Semaphorin interactions","HIV Life Cycle","Signaling by FGFR3 in disease","Toll
 Like Receptor 4 (TLR4) Cascade","Toll Like Receptor 2 (TLR2) Cascade","Signaling by FGFR1 in disease","G alpha (q) signalling events","Transcriptional Regulation by VENTX","PTK6 promotes HIF1A stabil
ization","Leishmania parasite growth and survival","G1 Phase","RET signaling","Signaling by NTRK1 (TRKA)","PTK6 Down-Regulation","Signaling by ROBO receptors","PTEN Regulation","Glycogen breakdown (gl
ycogenolysis)","Signaling by RAS mutants","VEGFA-VEGFR2 Pathway","MyD88 cascade initiated on plasma membrane","IRS-mediated signalling","Trafficking of AMPA receptors","Leishmania phagocytosis","Regul
ation of TP53 Activity","HDR through Homologous Recombination (HRR)","The role of Nef in HIV-1 replication and disease pathogenesis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Post NMDA recepto
r activation events","Mitotic Anaphase","Activation of the pre-replicative complex","Centrosome maturation","Interleukin-2 signaling","IRS-related events triggered by IGF1R","Activation of APC/C and A
PC/C:Cdc20 mediated degradation of mitotic proteins","VEGF binds to VEGFR leading to receptor dimerization","Sema4D in semaphorin signaling","Late Phase of HIV Life Cycle","Signaling by FGFR3 point mu
tants in cancer","MyD88-independent TLR4 cascade","Toll Like Receptor TLR6:TLR2 Cascade","FGFR1 mutant receptor activation","Gastrin-CREB signalling pathway via PKC and MAPK","Anti-inflammatory respon
se favouring Leishmania parasite infection","Cyclin D associated events in G1","Signalling to ERKs","CRMPs in Sema3A signaling","Activation of RAC1","Regulation of PTEN stability and activity","Signal
ing downstream of RAS mutants","VEGFR2 mediated cell proliferation","MAP kinase activation","PI3K Cascade","Trafficking of GluR2-containing AMPA receptors","FCGR3A-mediated phagocytosis","Regulation o
f TP53 Activity through Phosphorylation","Homologous DNA Pairing and Strand Exchange","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Activation of AM
PK downstream of NMDARs","Separation of Sister Chromatids","Long-term potentiation","Loss of proteins required for interphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degrad
ation of mitotic proteins","Sema4D induced cell migration and growth-cone collapse","Transcription of the HIV genome","FGFR3 mutant receptor activation","TRIF(TICAM1)-mediated TLR4 signaling","Regulat
ion of TP53 Expression and Degradation","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Signaling by activated point mutants of FGFR1","EGFR Transactivation by Gastrin","CREB1 phosphorylation
 through NMDA receptor-mediated activation of RAS signaling","FCGR3A-mediated IL10 synthesis","Prolonged ERK activation events","Nef and signal transduction","Sema4D mediated inhibition of cell attach
ment and migration","MAPK targets/ Nuclear events mediated by MAP kinases","Presynaptic phase of homologous DNA pairing and strand exchange","Nef Mediated CD4 Down-regulation","activated TAK1 mediates
 p38 MAPK activation","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","HIV Transcription Elongation","S
ignaling by activated point mutants of FGFR3","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Regulation of TP53 Degradation","Ras activation upon Ca2+ influx through NMDA receptor","Frs2-medi
ated activation","Activation of the AP-1 family of transcription factors","APC-Cdc20 mediated degradation of Nek2A","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-mediated elongation of t
he HIV-1 transcript","ERK/MAPK targets","CREB phosphorylation","Formation of HIV-1 elongation complex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
{PTK2}

> <broad_moa>
{"protein tyrosine kinase inhibitor"}

> <synonyms>
{761437-28-9,761437289,"NVP-TAE 226","NVPTAE 226",NVP-TAE226,NVPTAE226,TAE226,"TAE226 (NVP-TAE226)","TAE226 (NVPTAE226)",CHEMBL458997,TAE-226,CTx0152960,1042432-58-5,1042432585,"CTx-0152960;CTx 015296
0","CTx0152960;CTx 0152960",C23H25ClN6O3,2jkk,BI9,Kinome_1212,Kinome1212,Kinome-1212,"Kinome 1212","NVP TAE226",MLS006011059,SCHEMBL375524,GTPL9382,CHEBI:91452,DTXS,T1918,S2820}

> <pdid>
PD005165

> <targets>
{FAK,Apoptosis,IGF-1R,"Insulin Receptor",Pyk2}

> <classes>
{Angiogenesis,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{9934347}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 N   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6929   -4.0817    0.0000 C   0  0
    0.3385   -5.5341    0.0000 C   0  0
    1.4233   -6.5700    0.0000 C   0  0
    2.8629   -6.1484    0.0000 C   0  0
    3.9505   -7.1827    0.0000 O   0  0
    5.3902   -6.7589    0.0000 C   0  0
    6.4787   -7.7910    0.0000 C   0  0
    7.9168   -7.3644    0.0000 C   0  0
    8.2664   -5.9057    0.0000 C   0  0
    7.1780   -4.8736    0.0000 C   0  0
    5.7399   -5.3001    0.0000 C   0  0
    3.2176   -4.6910    0.0000 C   0  0
    2.1327   -3.6551    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.8813   -1.4408    0.0000 C   0  0
   -4.4481   -0.0574    0.0000 C   0  0
   -5.9346    0.1432    0.0000 C   0  0
   -6.8516   -1.0439    0.0000 C   0  0
   -6.2821   -2.4315    0.0000 N   0  0
   -4.7955   -2.6322    0.0000 C   0  0
   -7.1971   -3.6212    0.0000 C   0  0
   -8.6840   -3.4231    0.0000 O   0  0
   -6.6253   -5.0088    0.0000 C   0  0
   -7.5399   -6.1977    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 13 21  1  0
 21 22  2  0
 22 10  1  0
  9 23  1  0
 23  2  1  0
 23  6  2  0
  7 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 28 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  2  0
M  END
> <name>
UTKinase_V5

> <id>
28568

> <plate>
Kinase v5-2

> <well>
B09

> <supplier_cmpd_name>
PCI-32765 (Ibrutinib)

> <ctcr_id>
20

> <supplier_cmpd_id>
S2680

> <smiles>
Nc1ncnc2n(nc(c3ccc(Oc4ccccc4)cc3)c12)C5CCCN(C5)C(=O)C=C

> <pd_targets>
{ITK,TEC,ERBB4,FGR,FYN,ABL1,CSK,JAK3,BLK,BTK,EGFR,BMX,ERBB2,LYN,YES1,PTK6,CYP2C8,GSC2,CYP2C19,LCK,RET,CYP3A4,FRK,HCK,SRC,CYP2B6,FGFR2,CYP2C9,FER,KCNH2,TXK,PRXL2A}

> <pathway_gtopdb>
{Enzyme,"Ion channel","Unclassified protein",Kinase,"Cytochrome P450",Transferase,"Voltage-gated ion channel","Protein Kinase","Cytochrome P450 family 2","Cytochrome P450 family 3","Potassium channels
","TK protein kinase group","Cytochrome P450 family 2C","Cytochrome P450 family 3A","Cytochrome P450 family 2B","Voltage-gated potassium channel","Tyrosine protein kinase Tec family","Tyrosine protein
 kinase EGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Csk family","Tyrosine protein kinase JakA family","Cytochrome P450 2C8","Cytochr
ome P450 2C19","Tyrosine protein kinase Ret family","Cytochrome P450 3A4","Cytochrome P450 2B6","Tyrosine protein kinase FGFR family","Cytochrome P450 2C9","Tyrosine protein kinase Fer family","Tyrosi
ne protein kinase SrcA"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Cytochrome P450","Voltage-gated ion channels","Receptor kinases","CYP2 family: drug metabolising subset","CYP3 family","Potassium channels","TK
: Tyrosine kinase","Voltage-gated potassium channels","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Tec family","Type I RTKs: ErbB (epidermal growth factor) receptor fami
ly","Src family","Abl family","Csk family","Janus kinase (JakA) family","Type XIV RTKs: RET","Type V RTKs: FGF (fibroblast growth factor) receptor family","Fer family"}

> <pathway_reactome>
{"Immune System","Neuronal System",Disease,"Gene expression (Transcription)","Signal Transduction",Metabolism,"Developmental Biology","Cell Cycle","Muscle contraction","Adaptive Immune System","Cytoki
ne Signaling in Immune system","Transmission across Chemical Synapses","Infectious disease","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transc
ription","Signaling by GPCR","Metabolism of lipids","Nervous system development",Mitotic,"Biological oxidations","Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases"
,"Cardiac conduction","Innate Immune System","TCR signaling","Signaling by Interleukins","Neurotransmitter receptors and postsynaptic signal transmission","Leishmania infection","HIV Infection","Oncog
enic MAPK signaling","Generic Transcription Pathway","GPCR downstream signalling","Phospholipid metabolism","Axon guidance","Mitotic G1 phase and G1/S transition","Phase I - Functionalization of compo
unds","Biosynthesis of specialized proresolving mediators (SPMs)","PIP3 activates AKT signaling","Signaling by NTRKs","Signaling by FGFR in disease","Signaling by SCF-KIT","Phase 3 - rapid repolarisat
ion","Fc epsilon receptor (FCERI) signaling","Generation of second messenger molecules",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Activation of NMDA receptors and postsynaptic events","Leish
mania parasite growth and survival","Host Interactions of HIV factors","Parasite infection","Signaling by RAS mutants","Interleukin-2 family signaling","Transcriptional regulation by RUNX1","G alpha (
q) signalling events","PI Metabolism","Semaphorin interactions","G1 Phase","Cytochrome P450 - arranged by substrate type","RET signaling","Biosynthesis of DHA-derived SPMs","PTEN Regulation","Signalin
g by NTRK1 (TRKA)","Signaling by FGFR2 in disease","FCERI mediated Ca+2 mobilization","Post NMDA receptor activation events","Anti-inflammatory response favouring Leishmania parasite infection","The r
ole of Nef in HIV-1 replication and disease pathogenesis","Leishmania phagocytosis","Signaling downstream of RAS mutants","Interleukin-15 signaling","RUNX1 regulates transcription of genes involved in
 BCR signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Synthesis of PIPs at the plasma membrane","Sema4D in semaphorin signaling","Cyclin D associated events in G1",Xenobiotics,"Biosynthe
sis of maresins","Regulation of PTEN stability and activity","Signalling to ERKs","FGFR2 mutant receptor activation","Long-term potentiation","FCGR3A-mediated IL10 synthesis","Nef and signal transduct
ion","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone collapse","CYP2E1 reactions","Nef-mediates down modulation of cell surface receptor
s by recruiting them to clathrin adapters","Biosynthesis of maresin-like SPMs","Signalling to RAS","Activated point mutants of FGFR2","Nef Mediated CD4 Down-regulation","p38MAPK events"}

> <broad_targets>
{BLK,BMX,BTK}

> <broad_moa>
{"Bruton's tyrosine kinase (BTK) inhibitor"}

> <synonyms>
{"BRUTINIB (PCI32765","BRUTINIB (PCI 32765","PCI-32765 Racemate","PCI32765 Racemate","PCI 32765 Racemate",936563-87-0,936563870,"936563 87 0","PCI-32765 (Racemate)","PCI32765 (Racemate)","PCI 32765 (R
acemate)","Ibrutinib Racemate",S2680,ibrutinib,"Ibrutinib (PCI-32765)","PCI-32765 (Ibrutinib)"}

> <pdid>
PD003357

> <targets>
{Src,BTK}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{16126651}

$$$$
UTKinase_V5
  SciTegic11012413002D

 45 50  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    3.8976   -0.7553    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -7.7876   -1.5212    0.0000 N   0  0
   -7.7802   -3.0220    0.0000 C   0  0
   -6.4773   -3.7652    0.0000 O   0  0
   -9.0758   -3.7796    0.0000 N   0  0
   -9.0685   -5.2804    0.0000 C   0  0
  -10.3623   -6.0394    0.0000 C   0  0
  -10.3519   -7.5394    0.0000 C   0  0
   -9.0477   -8.2804    0.0000 C   0  0
   -7.7539   -7.5214    0.0000 C   0  0
   -7.7643   -6.0214    0.0000 C   0  0
   -9.0373   -9.7811    0.0000 C   0  0
  -10.3299  -10.5422    0.0000 N   0  0
  -10.3172  -12.0422    0.0000 C   0  0
   -9.0118  -12.7811    0.0000 N   0  0
   -7.7192  -12.0201    0.0000 C   0  0
   -7.7319  -10.5201    0.0000 N   0  0
   -6.4132  -12.7594    0.0000 N   0  0
   -6.3979  -14.2594    0.0000 C   0  0
   -5.0914  -14.9962    0.0000 C   0  0
   -3.8000  -14.2331    0.0000 O   0  0
   -3.8151  -12.7332    0.0000 C   0  0
   -5.1216  -11.9963    0.0000 C   0  0
  -11.6104  -12.8036    0.0000 N   0  0
  -12.9171  -12.0668    0.0000 C   0  0
  -14.2085  -12.8299    0.0000 C   0  0
  -14.1933  -14.3298    0.0000 O   0  0
  -12.8868  -15.0667    0.0000 C   0  0
  -11.5954  -14.3036    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  7 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 23 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
 30 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 32  1  0
 28 38  1  0
 38 39  1  0
 39 40  1  0
 40 41  1  0
 41 42  1  0
 42 43  1  0
 43 38  1  0
 15 44  1  0
 44 45  2  0
 45 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28569

> <plate>
Kinase v5-2

> <well>
B11

> <supplier_cmpd_name>
PF-05212384 (PKI-587)

> <ctcr_id>
5236

> <supplier_cmpd_id>
S2628

> <smiles>
CN(C)C1CCN(CC1)C(=O)c2ccc(NC(=O)Nc3ccc(cc3)c4nc(nc(n4)N5CCOCC5)N6CCOCC6)cc2

> <pd_targets>
{PIK3CD,MTOR,PIK3CA,PIK3CG,PIK3C3,PIK3C2B,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PIK3R5}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Phosphatidyl
inositol 3-kinase family","Phosphatidylinositol-4-phosphate 3-kinase family","FRAP subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)",Disease,Metabolism,"Signal Transduction","Cytokine Signaling in Immune system","RNA Polymerase II Transcription","Diseases of signal transduction by 
growth factor receptors and second messengers","Metabolism of lipids","Signaling by Receptor Tyrosine Kinases","Signaling by Interleukins","Generic Transcription Pathway","Signaling by FGFR in disease
","Phospholipid metabolism","Signaling by Insulin receptor",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","PI Metabolism","Ins
ulin receptor signalling cascade","Interleukin receptor SHC signaling","Regulation of TP53 Activity","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membrane","IRS-mediated signall
ing","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR,PIK3CA}

> <broad_moa>
{"mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{"F05212384 (PKI587",Gedatolisib,1197160-78-3,1197160783,PKI-587,PKI587,PF-05212384,PF05212384,"PKI 587","PF 05212384",UNII-96265TNH2R,UNII96265TNH2R,"PF-05212384 (PKI-587)","PF05212384 (PKI587)",CHEM
BL592445,"Gedatolisib (PF-05212384, PKI-587)","Gedatolisib (PF05212384, PKI587)",96265TNH2R,"PKI-587; PF-05212384","PKI587; PF05212384","Gedatolisib (USAN:INN)","PK 58",T1970,S2628}

> <pdid>
PD016682

> <targets>
{mTOR,PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{44516953}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 15  0  0  0  0            999 V2000
   11.4855   -3.3824    0.0000 H   0  3
    8.9855   -3.3824    0.0000 Cl  0  5
    6.4848   -8.2644    0.0000 N   0  0
    5.1873   -7.5117    0.0000 C   0  0
    3.8869   -8.2595    0.0000 N   0  0
    5.1894   -6.0109    0.0000 N   0  0
    3.8912   -5.2578    0.0000 C   0  0
    2.5909   -6.0056    0.0000 N   0  0
    3.8933   -3.7570    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  4  6  2  3
  6  7  1  0
  7  8  1  0
  7  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28570

> <plate>
Kinase v5-2

> <well>
B13

> <supplier_cmpd_name>
Phenformin hydrochloride

> <ctcr_id>
4077

> <supplier_cmpd_id>
S2542

> <smiles>
[H+].[Cl-].NC(N)=NC(N)=NCCc1ccccc1

> <pd_targets>
{TSHR,CYP2D26,HIF1A,CYP2D6,LMNA,MAPT,SLC22A1,SLC22A2,PRKAA1,KCNJ8}

> <pathway_gtopdb>
{"Membrane receptor",Enzyme,"Transcription factor","Other nuclear protein","Other cytosolic protein",Transporter,"Ion channel","Family A G protein-coupled receptor","Cytochrome P450","Electrochemical 
transporter",Kinase,"Voltage-gated ion channel","Peptide receptor (family A GPCR)","Cytochrome P450 family 2","SLC superfamily of solute carriers","Protein Kinase","Potassium channels","Glycohormone r
eceptor","Cytochrome P450 family 2D","SLC22 family of organic cation and anion transporters","CAMK protein kinase group","Inwardly rectifying potassium channel","Cytochrome P450 2D2","Cytochrome P450 
2D6","CAMK protein kinase CAMK1 family","CAMK protein kinase AMPK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Ion channels","G protein-coupled receptors","Cytochrome P450","SLC superfamily of solute carriers","Kinases (EC 2.7.x.x)","Voltage-gated ion channels","Glycoprotein ho
rmone receptors","CYP2 family: drug metabolising subset","SLC22 family of organic cation and anion transporters","CAMK: Calcium/calmodulin-dependent protein kinases","Potassium channels","Organic cati
on transporters (OCT)","CAMK-like (CAMKL) family","Inwardly rectifying potassium channels","AMPK subfamily"}

> <pathway_reactome>
{Disease,"Cellular responses to external stimuli",Metabolism,"Cell Cycle","Neuronal System","Transport of small molecules","Gene expression (Transcription)","Infectious disease","Cellular responses to
 stress","Biological oxidations",Mitotic,"Transmission across Chemical Synapses","SLC-mediated transmembrane transport","RNA Polymerase II Transcription","Potassium Channels","Leishmania infection","C
ellular response to hypoxia","Phase I - Functionalization of compounds","M Phase","Neurotransmitter receptors and postsynaptic signal transmission","Transport of bile salts and organic acids","metal i
ons and amine compounds","Generic Transcription Pathway","Inwardly rectifying K+ channels","Leishmania parasite growth and survival","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor
 Alpha","Cytochrome P450 - arranged by substrate type","Mitotic Metaphase and Anaphase","Activation of NMDA receptors and postsynaptic events","Organic cation/anion/zwitterion transport","Transcriptio
nal Regulation by TP53","ATP sensitive Potassium channels","Anti-inflammatory response favouring Leishmania parasite infection",Xenobiotics,"Mitotic Anaphase","Post NMDA receptor activation events","O
rganic cation transport","Regulation of TP53 Activity","ADORA2B mediated anti-inflammatory cytokines production","CYP2E1 reactions","Nuclear Envelope (NE) Reassembly","Activation of AMPK downstream of
 NMDARs","Regulation of TP53 Activity through Phosphorylation","Initiation of Nuclear Envelope (NE) Reformation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{AKOS026750110,"PHENFORMIN HYDROCHLORIDE",834-28-6,834286,"Phenformin HCl","Phenethylbiguanide hydrochloride",Meltrol,Dipar,Meltrol-50,Meltrol50,"1-Phenethylbiguanide hydrochloride","1Phenethylbiguani
de hydrochloride","Phenformin (hydrochloride)","USAF VI-6","USAF VI6","Imidodicarbonimidic di",S2542,1505983,Prestw-179,"Phenformin hydrochloride"}

> <pdid>
PD009649

> <targets>
{AMPK}

> <classes>
{antidiabetic}

> <pubchem_cids>
{657277,13266}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  1  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
    1.2946    3.7531    0.0000 O   0  0
   -1.3039    3.7494    0.0000 N   0  0
   -1.3070    5.2494    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 C   0  0
   -1.2990   -6.7517    0.0000 C   0  0
   -1.2990   -8.2525    0.0000 C   0  0  1  0  0  0
    0.0003   -9.0021    0.0000 C   0  0
   -2.5983   -7.5029    0.0000 O   0  0
   -2.5983   -9.0037    0.0000 C   0  0
   -2.5983  -10.5045    0.0000 O   0  0
   -3.8968  -11.2554    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  5 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17  3  1  0
 17 12  1  0
 15 18  1  0
 18 19  3  0
 19 20  1  0
 20 21  1  0
 20 22  1  1
 20 23  1  0
 23 24  1  0
 24 25  1  0
  4 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28571

> <plate>
Kinase v5-2

> <well>
B15

> <supplier_cmpd_name>
SAR131675

> <ctcr_id>
7246

> <supplier_cmpd_id>
S2842

> <smiles>
CCN1C(=C(C(=O)NC)C(=O)c2ccc(nc12)C#C[C@@](C)(O)COC)N

> <pd_targets>
{FLT4,KDR,FLT3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: P
DGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","Signaling by Insulin receptor","VEGF ligand-receptor interactions","VEGFA-VEGFR2 Pathway","Insulin receptor signall
ing cascade","VEGF binds to VEGFR leading to receptor dimerization","VEGFR2 mediated cell proliferation","IRS-mediated signalling","PI3K Cascade"}

> <broad_targets>
{FLT4}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{SAR131675,1433953-83-3,1433953833,SAR-131675,CHEMBL4303275,1092539-44-0,1092539440,"SAR 131675",SCHEMBL15668398,AOB5918,SYN1165,HMS3651B17,EX-A2154,EXA2154,2701AH,BDBM50509146,s2842,ZINC89630340,CCG-
268137,CCG268137,CS-0970,CS0970,SB19357,NCGC00386207-01,NCGC0038620701,AC-32832,AC32832,AK547384,AS-16301,AS16301,HY-15458,HY15458,SW219,S2842}

> <pdid>
PD056784

> <targets>
{VEGFR}

> <classes>
{}

> <pubchem_cids>
{71295845}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
   11.6990   -0.7503    0.0000 C   0  0
   10.3985   -1.4977    0.0000 N   0  0
    9.0998   -0.7454    0.0000 C   0  0
    9.1023    0.7546    0.0000 O   0  0
    7.7985   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -3.8916    3.7585    0.0000 C   0  0
   -3.8864    5.2585    0.0000 C   0  0
   -2.5847    6.0040    0.0000 C   0  0
   -2.5796    7.5040    0.0000 Cl  0  0
   -1.2883    5.2495    0.0000 C   0  0
   -1.2935    3.7495    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 C   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    6.4995   -3.7432    0.0000 C   0  0
    7.7985   -2.9932    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 15  1  0
 13 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 10  1  0
 26 22  2  0
  7 27  2  0
 27 28  1  0
 28 29  2  0
 29  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28572

> <plate>
Kinase v5-2

> <well>
B17

> <supplier_cmpd_name>
Telatinib (BAY 57-9352)

> <ctcr_id>
4687

> <supplier_cmpd_id>
S2231

> <smiles>
CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c4ccoc24)ccn1

> <pd_targets>
{KDR,FLT4,PDGFRB,KIT}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: P
DGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Signaling by Receptor Tyrosine Kinases","Intracellular signaling by second messengers","Diseases of signal transduction by growth factor receptors and second messengers
","Signaling by VEGF","PIP3 activates AKT signaling","Signaling by KIT in disease","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","Negative regulation of the PI3K/AKT network","Drug resist
ance of KIT mutants","VEGFR2 mediated cell proliferation","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Dasatinib-resistant KIT mutants"}

> <broad_targets>
{KDR}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{Telatinib,332012-40-5,332012405,"332012 40 5","Bay 57-9352","Bay 579352","Bay 57 9352","Telatinib (BAY 57-9352)","Telatinib (BAY 579352)","Telatinib (BAY 57 9352)",UNII-18P7197Q7J,UNII18P7197Q7J,"UNI
I 18P7197Q7J",BAY-579352,BAY579352,"BAY 579352",T6166,S2231}

> <pdid>
PD010812

> <targets>
{VEGFR,PDGFR,c-Kit}

> <classes>
{Protein Tyrosine Kinase,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{9808844}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 36  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1962   -1.5000    0.0000 C   0  0
   -5.1961   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -3.8971   -5.2500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2984   -3.7504    0.0000 C   0  0
    0.0020   -3.0025    0.0000 C   0  0
    1.2998   -3.7545    0.0000 C   0  0
    1.2974   -5.2545    0.0000 C   0  0
   -0.0028   -6.0025    0.0000 C   0  0
   -1.3006   -5.2504    0.0000 C   0  0
   -0.0052   -7.5033    0.0000 C   0  0
    1.2922   -8.2562    0.0000 F   0  0
   -1.3056   -8.2508    0.0000 F   0  0
   -0.0082   -9.0033    0.0000 F   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 24 26  1  0
 26 27  1  0
 26 28  1  0
 26 29  1  0
 19 30  1  0
 30 14  2  0
 30 31  1  0
 31 11  1  0
 31 32  2  0
 32  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28573

> <plate>
Kinase v5-2

> <well>
B19

> <supplier_cmpd_name>
Torin 2

> <ctcr_id>
4560

> <supplier_cmpd_id>
S2817

> <smiles>
Nc1ccc(cn1)c2ccc3ncc4C=CC(=O)N(c5cccc(c5)C(F)(F)F)c4c3c2

> <pd_targets>
{PIK3CD,PIK3R1,PIK3C2B,MTOR,PIK3CG,PI4KB,PRKDC,PIK3C3,PIK3CA,PIK3C2A,MLST8,RPTOR,ATR,ATM}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,"Phosphatidylinositol-4-phosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinosit
ol-4,"5-bisphosphate 3-kinase family","1-phosphatidylinositol 4-kinase family","Phosphatidylinositol 3-kinase family","FRAP subfamily","Other PIKK family kinases","ATR subfamily"}

> <pathway_reactome>
{Metabolism,"Gene expression (Transcription)","Immune System","Signal Transduction","DNA Repair",Disease,"Cell Cycle","Metabolism of lipids","RNA Polymerase II Transcription","Innate Immune System","S
ignaling by Receptor Tyrosine Kinases","Cytokine Signaling in Immune system","DNA Double-Strand Break Repair","Diseases of signal transduction by growth factor receptors and second messengers","Cell C
ycle Checkpoints","Phospholipid metabolism","Generic Transcription Pathway","Cytosolic sensors of pathogen-associated DNA","Signaling by Insulin receptor","Signaling by Interleukins","Homology Directe
d Repair","Signaling by FGFR in disease","G1/S DNA Damage Checkpoints","PI Metabolism","Transcriptional Regulation by TP53","STING mediated induction of host immune responses","Insulin receptor signal
ling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Signaling by FGFR1 in disease","p53-Dependent G1/S DNA d
amage checkpoint","Synthesis of PIPs at the plasma membrane","Regulation of TP53 Activity","Synthesis of PIPs at the Golgi membrane","IRF3-mediated induction of type I IFN","IRS-mediated signalling","
Interleukin receptor SHC signaling","Synthesis of PIPs at the early endosome membrane","HDR through Homologous Recombination (HRR)","FGFR1 mutant receptor activation","p53-Dependent G1 DNA Damage Resp
onse","Regulation of TP53 Expression and Degradation","PI3K Cascade","Homologous DNA Pairing and Strand Exchange","Signaling by cytosolic FGFR1 fusion mutants","Stabilization of p53","Regulation of TP
53 Degradation","Presynaptic phase of homologous DNA pairing and strand exchange","Autodegradation of the E3 ubiquitin ligase COP1"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{"Torin 2",1223001-51-1,1223001511,Torin2,Torin-2,CHEMBL1765602,C24H15F3N4O,CHEBI:90682,cc-275,cc275,MLS006011167,GTPL8839,SCHEMBL6876328,AOB3537,DTXSID00679917,EX-A431,EXA431,HMS3265O05,HMS3265O06,HM
S3265P05,HMS3265P06,HMS3651N13,BCP02612,ABP000908,BDBM50341209,MFCD187826,T6100,S2817}

> <pdid>
PD010558

> <targets>
{mTOR,ATM/ATR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{51358113}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 23  0  0  0  0            999 V2000
    6.4897   -5.2632    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    3.8912   -5.2578    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1937   -3.0093    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Br  0  0
    0.0000   -1.5000    0.0000 N   0  0
    1.2941   -3.7521    0.0000 C   0  0
   -0.0063   -4.4998    0.0000 N   0  0
    5.1873   -7.5117    0.0000 C   0  0
    6.4837   -8.2663    0.0000 C   0  0
    6.4785   -9.7663    0.0000 C   0  0
    5.1769  -10.5118    0.0000 C   0  0
    3.8804   -9.7573    0.0000 C   0  0
    3.8856   -8.2573    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 14  8  1  0
  6 15  1  0
 15 16  3  0
  2 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28574

> <plate>
Kinase v5-2

> <well>
B21

> <supplier_cmpd_name>
WP1066

> <ctcr_id>
3556

> <supplier_cmpd_id>
S2796

> <smiles>
CC(NC(=O)C(=Cc1cccc(Br)n1)C#N)c2ccccc2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{STAT3}

> <broad_moa>
{"STAT inhibitor"}

> <synonyms>
{HMS3656L10,AKOS026750371,AK-99218,AK99218,"AK 99218",DA-41141,DA41141,"DA 41141",FT-0700378,FT0700378,"FT 0700378",S2796,WP1066}

> <pdid>
PD010567

> <targets>
{JAK}

> <classes>
{JAK/STAT}

> <pubchem_cids>
{72752238}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 37  0  0  0  0            999 V2000
    5.0186   -7.7574    0.0000 C   0  0
    5.8033   -6.4790    0.0000 C   0  0
    7.3030   -6.5094    0.0000 O   0  0
    4.3640   -6.0568    0.0000 C   0  0
    4.8099   -4.6672    0.0000 C   0  0
    6.2255   -5.0397    0.0000 C   0  0
    4.2013   -3.2954    0.0000 C   0  0
    2.7345   -2.9814    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1968   -1.5004    0.0000 C   0  0
   -6.4971   -0.7525    0.0000 C   0  0
   -7.7950   -1.5046    0.0000 C   0  0
   -7.7926   -3.0046    0.0000 C   0  0
   -6.4923   -3.7525    0.0000 C   0  0
   -5.1945   -3.0005    0.0000 C   0  0
    3.9504   -0.8818    0.0000 C   0  0
    4.9525   -1.9980    0.0000 N   0  0
    6.4202   -1.6882    0.0000 C   0  0
    6.8858   -0.2623    0.0000 C   0  0
    5.8837    0.8539    0.0000 N   0  0
    4.4160    0.5441    0.0000 C   0  0
    3.4139    1.6603    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  2  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  1  0
 18 19  2  0
 19 10  1  0
 16 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
  9 26  2  0
 26 27  1  0
 27  7  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
 31 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28575

> <plate>
Kinase v5-2

> <well>
D03

> <supplier_cmpd_name>
Linsitinib (OSI-906)

> <ctcr_id>
5851

> <supplier_cmpd_id>
S1091

> <smiles>
CC1(O)CC(C1)c2nc(c3ccc4ccc(nc4c3)c5ccccc5)c6n2ccnc6N

> <pd_targets>
{IGF1R,ROCK2,MAP4K5,CDC42BPA,LYN,FLT4,ERBB4,NEK2,MARK3,KDR,AURKB,LCK,ROCK1,FRK,INSR,MARK2,RET,FGFR1,MAPK9,NEK4,BLK,MAP4K2,INSRR,ABCG2,ABCB1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","AGC protein kinase group","STE protein kinase group","Other protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Ty
rosine protein kinase InsR family","AGC protein kinase DMPK family","STE protein kinase STE20 family","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","Tyrosine protein kina
se EGFR family","Other protein kinase NEK family","CAMK protein kinase CAMK1 family","Other protein kinase AUR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase FGFR family","CMGC 
protein kinase MAPK family","AGC protein kinase ROCK subfamily","STE protein kinase KHS subfamily","AGC protein kinase GEK subfamily","CAMK protein kinase MARK subfamily","CMGC protein kinase JNK subf
amily",Transporter,"Primary active transporter","ATP-binding cassette","ABCG subfamily","ABCB subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: 
Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","DMPK family","STE20 family","Other protein kinases","CAMK-like (CAMKL) family","Mit
ogen-activated protein kinases (MAP kinases)","Receptor tyrosine kinases (RTKs)","Rho kinase","KHS subfamily","GEK subfamily","Non-receptor tyrosine kinases (nRTKs)","NIMA (never in mitosis gene a)- r
elated kinase (NEK) family","MARK subfamily","Aurora kinase (Aur) family","JNK subfamily","Type II RTKs: Insulin receptor family","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) 
receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XIV RTKs: RET","Type V RTKs: FGF (fibroblast growth factor) receptor family",Transporters,"ATP-binding cassette tra
nsporter family","ABCG subfamily","ABCB subfamily"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology",Disease,"Neuronal System","Cell Cycle","Immune System","Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Nervous system develop
ment","Infectious disease","Transmission across Chemical Synapses",Mitotic,"Diseases of signal transduction by growth factor receptors and second messengers","Intracellular signaling by second messeng
ers","Innate Immune System","RNA Polymerase II Transcription","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Axon guidance","Leishmania infection","Signaling by VEGF","Neurotrans
mitter receptors and postsynaptic signal transmission","Regulation of mitotic cell cycle","Oncogenic MAPK signaling","M Phase","HIV Infection","PIP3 activates AKT signaling","Signaling by FGFR in dise
ase","Toll-like Receptor Cascades","Generic Transcription Pathway","IGF1R signaling cascade","Semaphorin interactions","Leishmania parasite growth and survival","VEGF ligand-receptor interactions","Ac
tivation of NMDA receptors and postsynaptic events","APC/C-mediated degradation of cell cycle proteins","Signaling by RAS mutants","VEGFA-VEGFR2 Pathway","Mitotic Metaphase and Anaphase","Host Interac
tions of HIV factors","PTEN Regulation","Negative regulation of the PI3K/AKT network","RET signaling","Signaling by FGFR1 in disease","Toll Like Receptor 5 (TLR5) Cascade","Transcriptional regulation 
by RUNX1","IRS-related events triggered by IGF1R","Sema4D in semaphorin signaling","Anti-inflammatory response favouring Leishmania parasite infection","VEGF binds to VEGFR leading to receptor dimeriz
ation","Post NMDA receptor activation events","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Signaling downstream of RAS mutants","VEGFR2 mediated cell proliferation",
"Mitotic Anaphase","The role of Nef in HIV-1 replication and disease pathogenesis","Regulation of PTEN stability and activity",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","FGFR1 mutant receptor a
ctivation","MyD88 cascade initiated on plasma membrane","RUNX1 regulates transcription of genes involved in BCR signaling","Sema4D induced cell migration and growth-cone collapse","FCGR3A-mediated IL1
0 synthesis","Long-term potentiation","APC/C:Cdc20 mediated degradation of mitotic proteins","Separation of Sister Chromatids","Nef-mediates down modulation of cell surface receptors by recruiting the
m to clathrin adapters","Signaling by activated point mutants of FGFR1","MAP kinase activation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","APC-Cdc20 mediated degradation of Nek2A","Activation of the AP-1 family of transcription factors",Metabolis
m,"Abacavir transport and metabolism","Abacavir transmembrane transport"}

> <broad_targets>
{IGF1R,INSR,INSRR}

> <broad_moa>
{"IGF-1 inhibitor"}

> <synonyms>
{"INSITINIB (OSI906","INSITINIB (OSI 906",Linsitinib,867160-71-2,867160712,"867160 71 2",OSI-906,OSI906,"OSI 906",Linsitinib(OSI-906),Linsitinib(OSI906),"Linsitinib(OSI 906)","OSI-906 (Linsitinib)","O
SI906 (Linsitinib)","OSI 906 (Linsitinib)",OSI-906AA,OSI906AA,"OSI 906AA",ASP-7487,ASP7487,"ASP 7487",UNII-15A52GPT8T,UNII15A52GPT8T,"UNII 15A52GPT8T",15A52GPT8T,CHEMBL1091644,MMV676605,C26H23N5O,Kino
me_3532,Kinome3532,Kinome-3532,"Kinome 3532","Linsitinib (USAN:INN)",OSI906/Linsitinib/,Linsi,T6017,S1091,"OSI-906 (Linsitinib)","Linsitinib (OSI-906)"}

> <pdid>
PD003549

> <targets>
{IGF-1R}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{11640390}

$$$$
UTKinase_V5
  SciTegic11012413002D

 47 51  0  0  0  0            999 V2000
    7.7938   -3.0152    0.0000 C   0  0
    6.4915   -3.7597    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.0114   -1.7530    0.0000 N   0  0
   -6.4786   -1.4410    0.0000 C   0  0
   -4.4013   -3.1233    0.0000 C   0  0
   -5.1513   -4.4224    0.0000 O   0  0
   -2.9095   -2.9665    0.0000 N   0  0
   -1.9052   -4.0817    0.0000 C   0  0
   -0.4237   -3.8808    0.0000 C   0  0
    0.4933   -5.0678    0.0000 C   0  0
   -0.0761   -6.4555    0.0000 C   0  0
    0.8414   -7.6431    0.0000 N   0  0
    2.3283   -7.4449    0.0000 C   0  0
    3.2434   -8.6334    0.0000 C   0  0
    2.6718  -10.0201    0.0000 N   0  0
    1.1850  -10.2185    0.0000 C   0  0
    0.2698   -9.0300    0.0000 C   0  0
   -1.5627   -6.6562    0.0000 C   0  0
   -2.4797   -5.4692    0.0000 C   0  0
   -2.1324   -8.0446    0.0000 C   0  0
   -1.2161   -9.2322    0.0000 F   0  0
   -3.1235   -8.1781    0.0000 F   0  0
   -2.5125   -8.9696    0.0000 F   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   10.2915   -2.2136    0.0000 O   0  0
   10.2915   -3.7136    0.0000 C   0  0
    8.9923   -4.4632    0.0000 O   0  0
   11.5915   -4.4636    0.0000 C   0  0
   12.8915   -3.7136    0.0000 C   0  0
   14.1915   -4.4636    0.0000 C   0  0
   15.4908   -3.7140    0.0000 O   0  0
   14.1915   -5.9636    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  6  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 25  1  0
 24 31  1  0
 31 32  2  0
 32 21  1  0
 31 33  1  0
 33 34  1  0
 33 35  1  0
 33 36  1  0
 20 37  1  0
 37 15  2  0
 37 38  1  0
 38 12  1  0
 38 39  2  0
 39  9  1  0
 40 41  1  0
 41 42  2  0
 41 43  1  0
 43 44  2  3
 44 45  1  0
 45 46  2  0
 45 47  1  0
M  END
> <name>
UTKinase_V5

> <id>
28576

> <plate>
Kinase v5-2

> <well>
D05

> <supplier_cmpd_name>
NVP-BGT226

> <ctcr_id>
3387

> <supplier_cmpd_id>
S2749

> <smiles>
COc1ccc(cn1)c2ccc3ncc4N(C)C(=O)N(c5ccc(N6CCNCC6)c(c5)C(F)(F)F)c4c3c2.OC(=O)C=CC(=O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{VPBGT22,BGT226,"NVP-BGT226 (BGT226","NVPBGT226 (BGT226",HMS3656L21,HMS3672I05,BCP03599,AK175526,T6072,S2749,NVP-BGT226,"BGT226 (NVP-BGT226)"}

> <pdid>

> <targets>
{PI3K,mTOR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{66870970}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  1  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 C   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5536   -4.4230    0.0000 C   0  0
   -1.8244   -5.7203    0.0000 N   0  0
   -2.8573   -6.8079    0.0000 C   0  0
   -2.5846   -8.2837    0.0000 C   0  0  2  0  0  0
   -1.2168   -8.8872    0.0000 C   0  0
   -1.0559  -10.3786    0.0000 C   0  0
   -2.2670  -11.2635    0.0000 C   0  0  2  0  0  0
   -3.6390  -10.6572    0.0000 C   0  0
   -3.7999   -9.1658    0.0000 C   0  0
   -2.1091  -12.7561    0.0000 C   0  0
   -3.3215  -13.6393    0.0000 O   0  0
   -0.7382  -13.3648    0.0000 O   0  0
   -4.2101   -6.1617    0.0000 N   0  0
   -5.5962   -6.7352    0.0000 N   0  0
   -6.7859   -5.8216    0.0000 C   0  0
   -6.5895   -4.3345    0.0000 N   0  0
   -5.2035   -3.7611    0.0000 C   0  0
   -5.0071   -2.2740    0.0000 N   0  0
   -4.0138   -4.6747    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11  3  1  0
 11  7  2  0
  9 12  1  0
 12 13  1  0
 13 14  2  0
 15 14  1  6
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 15  1  0
 18 21  1  1
 21 22  2  0
 21 23  1  0
 14 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 28 30  1  0
 30 12  2  0
 30 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28577

> <plate>
Kinase v5-2

> <well>
D07

> <supplier_cmpd_name>
OSI-027

> <ctcr_id>
7229

> <supplier_cmpd_id>
S2624

> <smiles>
COc1cccc2cc([nH]c12)c3nc([C@@H]4CC[C@H](CC4)C(=O)O)n5ncnc(N)c35

> <pd_targets>
{MTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by TP53","Regulation of TP53 Activity","Regulation of TP53 Expression a
nd Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{OSI-027,OSI027,"OSI 027",936890-98-1,936890981,"936890 98 1",UNII-25MKH1SZ0M,UNII25MKH1SZ0M,"UNII 25MKH1SZ0M",25MKH1SZ0M,CHEMBL2132692,CHEMBL3120215,"936890-98-1 (free acid)","936890981 (free acid)",
"936890 98 1 (free acid)",1187559-66-5,1187559665,S2624}

> <pdid>
PD003638

> <targets>
{mTOR}

> <classes>
{}

> <pubchem_cids>
{135398516}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 40  0  0  0  0            999 V2000
    6.4833   -9.7648    0.0000 C   0  0
    6.4855   -8.2648    0.0000 C   0  0
    5.1873   -7.5117    0.0000 N   0  0
    3.8847   -8.2572    0.0000 C   0  0
    2.5880   -7.5031    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1953   -1.5031    0.0000 N   0  0
   -5.1932   -3.0039    0.0000 C   0  0
   -3.8928   -3.7517    0.0000 O   0  0
   -6.4914   -3.7570    0.0000 N   0  0
   -6.4892   -5.2579    0.0000 C   0  0
   -7.7867   -6.0105    0.0000 C   0  0
   -6.4864   -6.7579    0.0000 C   0  0
   -5.1889   -6.0056    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -6.4995    3.7483    0.0000 C   0  0
   -6.5050    5.2492    0.0000 O   0  0
   -7.8063    5.9952    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -9.0920    0.7411    0.0000 O   0  0
   -9.0875   -0.7589    0.0000 C   0  0
   -6.4948    0.7483    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 22 25  1  0
 17 26  2  0
 26 27  1  0
 27 14  1  0
 27 28  2  0
 28 11  1  0
 16 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 31 34  2  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 35 38  2  0
 38 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28578

> <plate>
Kinase v5-2

> <well>
D09

> <supplier_cmpd_name>
PD173074

> <ctcr_id>
5906

> <supplier_cmpd_id>
S1264

> <smiles>
CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)c3cc(OC)cc(OC)c3

> <pd_targets>
{FGFR2,FGFR3,FGFR1,KDR,ATM,GLA,CSK,SRC,PDGFRB,RORC,FGFR4,PDGFRA,FLT1,FLT4}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,Hydrolase,"Nuclear receptor","Protein Kinase","Nuclear hormone receptor subfamily 1","TK protein kinase group","Atypical protein kinase group","Nuclear hormone re
ceptor subfamily 1 group F","Tyrosine protein kinase FGFR family","Tyrosine protein kinase VEGFR family","Atypical protein kinase PIKK family","Tyrosine protein kinase Csk family","Tyrosine protein ki
nase Src family","Tyrosine protein kinase PDGFR family","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Receptor kinases",Atypical,"1F. Retinoic acid-related orphans","TK: Tyrosine kinase","Phosphatidyl inositol
 3' kinase-related kinases (PIKK) family","Receptor tyrosine kinases (RTKs)","Other PIKK family kinases","Non-receptor tyrosine kinases (nRTKs)","Type V RTKs: FGF (fibroblast growth factor) receptor f
amily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Csk family","Src family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Cell Cycle",Metabolism,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyros
ine Kinases","Cell Cycle Checkpoints","Metabolism of lipids","Intracellular signaling by second messengers","RNA Polymerase II Transcription","Signaling by FGFR in disease","Signaling by VEGF","G1/S D
NA Damage Checkpoints","Sphingolipid metabolism","Oncogenic MAPK signaling","Signaling by NTRKs","PIP3 activates AKT signaling","Generic Transcription Pathway","Signaling by FGFR2 in disease","Signali
ng by FGFR3 in disease","Signaling by FGFR1 in disease","VEGFA-VEGFR2 Pathway","p53-Dependent G1/S DNA damage checkpoint","Glycosphingolipid metabolism","Signaling by RAS mutants","Signaling by NTRK1 
(TRKA)","Negative regulation of the PI3K/AKT network","Transcriptional regulation by RUNX3","FGFR2 mutant receptor activation","Signaling by FGFR3 point mutants in cancer","FGFR1 mutant receptor activ
ation","VEGFR2 mediated cell proliferation","p53-Dependent G1 DNA Damage Response","Signaling downstream of RAS mutants","Signalling to ERKs",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","RUNX3 Re
gulates Immune Response and Cell Migration","Activated point mutants of FGFR2","FGFR3 mutant receptor activation","Signaling by activated point mutants of FGFR1","Stabilization of p53","Signalling to 
RAS","Signaling by activated point mutants of FGFR3","Autodegradation of the E3 ubiquitin ligase COP1","p38MAPK events"}

> <broad_targets>
{FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,KDR,PDGFRA,PDGFRB}

> <broad_moa>
{"FGFR inhibitor","VEGFR inhibitor"}

> <synonyms>
{219580-11-7,219580117,PD173074,"PD 173074",PD-173074,UNII-A4TLL8634Y,UNIIA4TLL8634Y,A4TLL8634Y,CHEMBL189584,PD-0173074,PD0173074,CHEBI:63448,C28H41N7O3,MFCD08705327,2fgi,SMR000568412,"FGF/VEGF Recept
or Tyrosine Kinase Inhibitor, PD173074",PubChem22593,cc-523,cc523,MLS001074892,MLS006011,T2642,S1264}

> <pdid>
PD011036

> <targets>
{FGFR,VEGFR,Apoptosis}

> <classes>
{Angiogenesis,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{1401}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 32  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987   -1.5004    0.0000 N   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -3.8919   -5.2525    0.0000 Br  0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -1.2962   -3.7484    0.0000 O   0  0
   -6.4946   -3.7544    0.0000 O   0  0
   -7.7945   -3.0042    0.0000 C   0  0
   -9.0946   -3.7540    0.0000 C   0  0
   -9.0923   -5.2541    0.0000 C   0  0
  -10.3902   -6.0061    0.0000 C   0  0
  -11.6904   -5.2581    0.0000 C   0  0
  -12.9883   -6.0102    0.0000 F   0  0
  -11.6927   -3.7581    0.0000 C   0  0
  -10.3949   -3.0061    0.0000 C   0  0
  -10.3973   -1.5061    0.0000 F   0  0
   -3.9015    0.7475    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 11  5  1  0
 10 12  1  0
 12 13  1  0
 13 14  2  3
 14 15  1  0
 15 16  2  3
 16 17  1  0
 16 18  1  0
 18 12  1  0
 18 19  2  0
 15 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 22  1  0
 28 29  1  0
 13 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28579

> <plate>
Kinase v5-2

> <well>
D11

> <supplier_cmpd_name>
PH-797804

> <ctcr_id>
6015

> <supplier_cmpd_id>
S2726

> <smiles>
CNC(=O)c1ccc(C)c(c1)N2C(=CC(=C(Br)C2=O)OCc3ccc(F)cc3F)C

> <pd_targets>
{MAPK14,MAPK11,ROCK2,MAPK12}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","AGC protein kinase group","CMGC protein kinase MAPK family","AGC protein kinase DMPK family","CMGC protein kinase p38 subfamily","AGC prote
in kinase ROCK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","Mitogen-activated protein kinases (MAP kinases)","DMPK family","p38 subfamily"
,"Rho kinase"}

> <pathway_reactome>
{"Immune System","Developmental Biology","Signal Transduction","Innate Immune System","Nervous system development","Signaling by Receptor Tyrosine Kinases","Toll-like Receptor Cascades","Axon guidance
","Signaling by NTRKs","Toll Like Receptor 5 (TLR5) Cascade","Semaphorin interactions","Signaling by NTRK1 (TRKA)","MyD88 cascade initiated on plasma membrane","Sema4D in semaphorin signaling","Signal
ling to ERKs","MAP kinase activation","Sema4D induced cell migration and growth-cone collapse","Signalling to RAS","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","Activation o
f the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK11,MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{PH-797804,PH797804,586379-66-0,586379660,"PH 797804",UNII-SI09I1V827,UNIISI09I1V827,UNII-GEL7GRJ3R6,UNIIGEL7GRJ3R6,GEL7GRJ3R6,CHEMBL1088751,CHEBI:82715,SI09I1V827,PHA-797804,PHA797804,1358027-80-1,13
58027801,3hll,Kinome_3761,Kinome3761,Kinome-3761,"Kinome 3761",cc-53,cc53,MLS006011016,C22H19BrF2N2O3,"rac-PH 797804","racPH 797804",GTPL7818,SCHEMBL2015676,DTXSID70207,T1974,S2726}

> <pdid>
PD004869

> <targets>
{"p38 MAPK",Autophagy}

> <classes>
{MAPK,Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{22049997}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 47  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -6.5018    3.7420    0.0000 N   0  0
   -7.7993    2.9876    0.0000 C   0  0
   -7.7943    1.4876    0.0000 O   0  0
   -9.1017    3.7333    0.0000 N   0  0
  -10.3992    2.9790    0.0000 C   0  0
  -11.7021    3.7223    0.0000 C   0  0
  -12.9973    2.9658    0.0000 C   0  0
  -12.9898    1.4658    0.0000 C   0  0
  -11.6870    0.7224    0.0000 C   0  0
  -10.3917    1.4789    0.0000 C   0  0
  -14.2842    0.7062    0.0000 C   0  0
  -15.5883    1.4473    0.0000 O   0  0
  -14.2744   -0.7946    0.0000 N   0  0
  -15.5670   -1.5558    0.0000 C   0  0
  -15.5543   -3.0557    0.0000 C   0  0
  -14.2489   -3.7946    0.0000 N   0  0
  -14.2361   -5.2946    0.0000 C   0  0
  -12.9563   -3.0336    0.0000 C   0  0
  -12.9690   -1.5336    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
    2.5987    1.5004    0.0000 N   0  0
    3.8991    0.7525    0.0000 C   0  0
    5.1969    1.5046    0.0000 C   0  0
    5.1945    3.0046    0.0000 O   0  0
    3.8943    3.7525    0.0000 C   0  0
    2.5964    3.0004    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  3  1  0
 11  6  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 23 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 31 33  1  0
 33 34  1  0
 34 28  1  0
 15 35  1  0
 35 36  2  0
 36 12  1  0
  7 37  1  0
 37 38  1  0
 38 39  1  0
 39 40  1  0
 40 41  1  0
 41 42  1  0
 42 37  1  0
M  END
> <name>
UTKinase_V5

> <id>
28580

> <plate>
Kinase v5-2

> <well>
D13

> <supplier_cmpd_name>
PKI-402

> <ctcr_id>
290

> <supplier_cmpd_id>
S2739

> <smiles>
CCn1nnc2c(nc(nc12)c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N5CCN(C)CC5)cc3)N6CCOCC6

> <pd_targets>
{PIK3CD,PIK3CB,MTOR,PIK3CA,PIK3CG}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfami
ly"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Gene expression (Transcription)",Disease,Metabolism,"Cytokine Signaling in Immune system","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcript
ion","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","Signaling by Interleukins","Signaling by Insulin receptor","Generic Transcription Pathwa
y","Signaling by FGFR in disease","Phospholipid metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","Transcriptional Regulation by TP53","Signaling by 
FGFR1 in disease","PI Metabolism","Interleukin receptor SHC signaling","IRS-mediated signalling","Regulation of TP53 Activity","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membr
ane","PI3K Cascade","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{KI40,PKI-402,PKI402,1173204-81-3,1173204813,CHEMBL589258,"PKI 402",cc-193,cc193,MLS006010978,SCHEMBL3401810,DTXSID30657809,EX-A040,EXA040,BCP02609,C29H34N10O3,ABP000110,BDBM50308767,MFCD18251484,s273
9,ZINC49745945,AKOS022526182,CS-0565,CS0565,QC-7256,QC7256,SB19253,NCGC00346649-01,NCGC0034664901,NCGC0034,S2739}

> <pdid>
PD012920

> <targets>
{PI3K}

> <classes>
{}

> <pubchem_cids>
{44187953}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
   -2.1080   -7.6698    0.0000 C   0  0
   -1.8348   -6.1949    0.0000 N   0  0
   -0.4810   -5.5489    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1519   -3.7886    0.0000 C   0  0
   -2.8675   -5.1069    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Br  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -5.1969    1.4963    0.0000 N   0  0
   -3.8967    0.7484    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17  7  2  0
 17 10  1  0
 15 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28581

> <plate>
Kinase v5-2

> <well>
D15

> <supplier_cmpd_name>
SCH 900776

> <ctcr_id>
3051

> <supplier_cmpd_id>
S2735

> <smiles>
Cn1cc(cn1)c2cnn3c(N)c(Br)c(nc23)C4CCCNC4

> <pd_targets>
{CHEK1,CDK2,CCNA1,CCNA2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CMGC protein kinase group","CAMK protein kinase CAMK1 family","CMGC protein kinase CDK family","CAMK protein kinase CHK1 subfamily","CMGC p
rotein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK-like (CAMKL) family","Cyclin-dependent kinase (CDK) family","
CHK1 subfamily","CDK1 subfamily"}

> <pathway_reactome>
{"DNA Repair","Gene expression (Transcription)","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Homology Directed Repair","Generic Transcription Pathway","HDR through Homologous Re
combination (HRR) or Single Strand Annealing (SSA)","Transcriptional Regulation by TP53","HDR through Homologous Recombination (HRR)","Regulation of TP53 Activity","Homologous DNA Pairing and Strand E
xchange","Regulation of TP53 Expression and Degradation","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation"}

> <broad_targets>
{CDK2,CHEK1}

> <broad_moa>
{"CHK inhibitor"}

> <synonyms>
{MK-8776,MK8776,"MK-8776 Racemate","MK8776 Racemate","MK-8776 S-isomer","MK8776 Sisomer","SCH900776 (Racemate)",CHEMBL1643208,891495-88-8,891495888,"SCH900776 S-isomer","SCH900776 Sisomer",GTPL7943,SC
HEMBL10380123,CHEBI:131165,HMS3656J19,BCP02883,BDBM50334854,NSC764659,AKOS026750519,"MK 8776",NSC-764659,NCGC003878,S2735,"MK-8776 (SCH 900776)","SCH 900776"}

> <pdid>
PD010691

> <targets>
{Chk,CDK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{16224745}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
    5.1937   -3.0093    0.0000 O   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    5.1017   -6.1219    0.0000 C   0  0
    4.6332   -7.5468    0.0000 S   0  0
    3.1332   -7.5416    0.0000 C   0  0
    2.2459   -8.7488    0.0000 N   0  0
    0.7541   -8.5846    0.0000 C   0  0
   -0.1361   -9.7919    0.0000 C   0  0
   -1.6268   -9.6248    0.0000 C   0  0
   -2.2274   -8.2502    0.0000 N   0  0
   -1.3373   -7.0429    0.0000 C   0  0
    0.1534   -7.2100    0.0000 N   0  0
    2.6747   -6.1134    0.0000 N   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  2 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 14 22  2  0
 22 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28582

> <plate>
Kinase v5-2

> <well>
D17

> <supplier_cmpd_name>
Thiazovivin

> <ctcr_id>
2660

> <supplier_cmpd_id>
S1459

> <smiles>
O=C(NCc1ccccc1)c2csc(Nc3ccncn3)n2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"rho associated kinase inhibitor"}

> <synonyms>
{Thiazovivin,1226056-71-8,1226056718,N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide,Nbenzyl2(pyrimidin4ylamino)thiazole4carboxamide,"N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
","Nbenzyl2(pyrimidin4ylamino)1,3thiazole4carboxamide",C15H13N5OS,N-Benzyl-2-(pyrimidin-4-ylamino)-thiazole-4-carboxamide,NBenzyl2(pyrimidin4ylamino)thiazole4carboxamide,N-(PHENYLMETHYL)-2-(4-PYRIMIDI
NYLA,N(PHENYLMETHYL)2(4PYRIMIDINYLA,T2155,S1459}

> <pdid>
PD011183

> <targets>
{ROCK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{46209426}

$$$$
UTKinase_V5
  SciTegic11012413002D

 19 20  0  0  0  0            999 V2000
    6.1718    0.7439    0.0000 N   0  0
    7.0537   -0.4695    0.0000 C   0  0
    8.5454   -0.3119    0.0000 O   0  0
    6.4430   -1.8405    0.0000 N   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.8054   -4.6666    0.0000 C   0  0
    6.2966   -4.8284    0.0000 N   0  0
    3.9200   -5.8774    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9  5  2  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
  7 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28583

> <plate>
Kinase v5-2

> <well>
D19

> <supplier_cmpd_name>
TPCA-1

> <ctcr_id>
6789

> <supplier_cmpd_id>
S2824

> <smiles>
NC(=O)Nc1sc(cc1C(N)=O)c2ccc(F)cc2

> <pd_targets>
{IKBKB,JAK2,EIF2AK2,KMT2A,MEN1}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,"Protein Kinase",Bromodomain,"Other protein kinase group","TK protein kinase group","Other protein kinase IKK family","Tyrosine protein kinase JakA family"
,"Other protein kinase PEK family","Other protein kinase PKR"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","TK: Tyrosine kinase","IKK family","Non-receptor tyrosine kinases (nRTKs)","PEK family","Janus kinase (JakA) family","Other 
PEK family kinases"}

> <pathway_reactome>
{"Immune System","Cell Cycle",Disease,"Innate Immune System",Mitotic,"Infectious disease","Toll-like Receptor Cascades","Mitotic G1 phase and G1/S transition","Influenza Infection","Toll Like Receptor
 4 (TLR4) Cascade","G1 Phase","NS1 Mediated Effects on Host Pathways","MyD88-independent TLR4 cascade","Cyclin D associated events in G1","Inhibition of PKR","TRIF(TICAM1)-mediated TLR4 signaling","IK
K complex recruitment mediated by RIP1"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor"}

> <synonyms>
{PCA,TPCA-1,TPCA1,507475-17-4,507475174,5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide,5(4Fluorophenyl)2ureidothiophene3carboxamide,"IKK-2 Inhibitor IV","IKK2 Inhibitor IV",2-(carbamoylamino)-5-(4
-fluorophenyl)thiophene-3-carboxamide,2(carbamoylamino)5(4fluorophenyl)thiophene3carboxamide,(5-(p-Fluorophenyl)-2-ureido)thiophene-3-carboxamide,(5(pFluorophenyl)2ureido)thiophene3carboxamide,CHEMBL2
57167,MFCD,T3049,2559,"EMD 401481",S2824,401481}

> <pdid>
PD002651

> <targets>
{IKK}

> <classes>
{}

> <pubchem_cids>
{9903786}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 25  0  0  0  0            999 V2000
    7.7882   -3.0088    0.0000 C   0  0
    6.4894   -3.7592    0.0000 C   0  0
    6.4889   -5.2601    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    3.8912   -5.2578    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1937   -3.0093    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Br  0  0
    0.0000   -1.5000    0.0000 N   0  0
    1.2941   -3.7521    0.0000 C   0  0
   -0.0063   -4.4998    0.0000 N   0  0
    5.1873   -7.5117    0.0000 C   0  0
    6.4837   -8.2663    0.0000 C   0  0
    6.4785   -9.7663    0.0000 C   0  0
    5.1769  -10.5118    0.0000 C   0  0
    3.8804   -9.7573    0.0000 C   0  0
    3.8856   -8.2573    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 14 16  2  0
 16 10  1  0
  8 17  1  0
 17 18  3  0
  4 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28584

> <plate>
Kinase v5-2

> <well>
D21

> <supplier_cmpd_name>
WP1130

> <ctcr_id>
850

> <supplier_cmpd_id>
S2243

> <smiles>
CCCC(NC(=O)C(=Cc1cccc(Br)n1)C#N)c2ccccc2

> <pd_targets>
{USP9X,UCHL1,USP5}

> <pathway_gtopdb>
{Enzyme,Protease,"Cysteine protease","Cysteine protease CA clan","Cysteine protease C19 family","Cysteine protease C12 family"}

> <pathway_chembl>
{Enzymes,"Peptidases and proteinases","CA: Cysteine (C) Peptidases","C12: Ubiquitin C-terminal hydrolase","C19: Ubiquitin-specific protease"}

> <pathway_reactome>
{"Gene expression (Transcription)","Metabolism of proteins","RNA Polymerase II Transcription","Post-translational protein modification","Generic Transcription Pathway",Deubiquitination,"Transcriptiona
l activity of SMAD2/SMAD3:SMAD4 heterotrimer","UCH proteinases","Ub-specific processing proteases","Downregulation of SMAD2/3:SMAD4 transcriptional activity"}

> <broad_targets>
{JAK2,UCHL5,USP14,USP9X}

> <broad_moa>
{"deubiquitinase inhibitor"}

> <synonyms>
{CHEMBL2138527,HMS3655P14,BCP02590,T6300,S2243,Degrasyn,WP1130,"Degrasyn (WP1130)"}

> <pdid>
PD003660

> <targets>
{DUB,Bcr-Abl}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{72757535}

$$$$
UTKinase_V5
  SciTegic11012413002D

 19 21  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -6.4995    3.7483    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -9.0928    0.7442    0.0000 O   0  0
   -6.4948    0.7483    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  6  1  0
 11 12  2  0
 12  2  1  0
  8 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 19 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28585

> <plate>
Kinase v5-2

> <well>
F03

> <supplier_cmpd_name>
TG 100713

> <ctcr_id>
1940

> <supplier_cmpd_id>
S2870

> <smiles>
Nc1nc(N)c2nc(cnc2n1)c3cccc(O)c3

> <pd_targets>
{PIK3CG,PIK3CB,PIK3CA}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{Metabolism,"Signal Transduction",Disease,"Metabolism of lipids","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Phospholip
id metabolism","Signaling by Insulin receptor","Signaling by FGFR in disease","PI Metabolism","Insulin receptor signalling cascade","Signaling by FGFR1 in disease","Synthesis of PIPs at the plasma mem
brane","IRS-mediated signalling","FGFR1 mutant receptor activation","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
{}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{925705-73-3,925705733,"TG 100713","3-(2,4-diaminopteridin-6-yl)phenol","3(2,4diaminopteridin6yl)phenol",TG100713,C12H10N6O,tg-100713,tg100713,"3-(2,4-DIAMINO-6-PTERIDINYL)-PHENOL","3(2,4DIAMINO6PTERI
DINYL)PHENOL",cc-655,cc655,SCHEMBL369049,CHEMBL244559,"JMC504279 Compound 17",BDBM25082,DTXSID60590816,HMS3651N21,BCP05993,2752AH,s2870,S2870}

> <pdid>
PD010537

> <targets>
{PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{17751063}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.6012    3.0008    0.0000 O   0  0
   -3.9020    3.7494    0.0000 C   0  0
   -3.9073    5.2494    0.0000 C   0  0
   -5.2089    5.9949    0.0000 C   0  0
   -6.5054    5.2404    0.0000 C   0  0
   -7.8093    5.9836    0.0000 N   0  0
   -9.1053    5.2269    0.0000 C   0  0
   -9.0975    3.7269    0.0000 O   0  0
  -10.4092    5.9701    0.0000 C   0  0
  -11.7584    5.3444    0.0000 C   0  0
  -12.0565    3.8743    0.0000 C   0  0
  -12.7660    6.4556    0.0000 N   0  0
  -14.2558    6.2969    0.0000 C   0  0
  -15.1404    7.5093    0.0000 C   0  0
  -14.5327    8.8807    0.0000 C   0  0
  -16.0240    8.7215    0.0000 C   0  0
  -16.6320    7.3504    0.0000 O   0  0
  -12.0205    7.7572    0.0000 N   0  0
  -10.5522    7.4505    0.0000 C   0  0
   -9.4350    8.4514    0.0000 O   0  0
  -12.6357    9.1261    0.0000 C   0  0
  -14.1076    9.3878    0.0000 C   0  0
  -14.6178   10.7984    0.0000 C   0  0
  -13.6513   11.9455    0.0000 C   0  0
  -12.1746   11.6820    0.0000 C   0  0
  -11.6644   10.2715    0.0000 C   0  0
   -6.5002    3.7404    0.0000 N   0  0
   -5.1985    2.9949    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  2  3
 17 18  1  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 21 23  1  0
 21 24  1  0
 19 25  1  0
 25 26  1  0
 26 16  1  0
 26 27  2  0
 25 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 12 34  1  0
 34 35  2  0
 35  9  1  0
  7 36  2  0
 36 37  1  0
 37 38  2  0
 38 39  1  0
 39  6  1  0
 39 40  2  0
 40  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28586

> <plate>
Kinase v5-2

> <well>
F05

> <supplier_cmpd_name>
AMG458

> <ctcr_id>
6438

> <supplier_cmpd_id>
S2747

> <smiles>
COc1ccc2c(Oc3ccc(NC(=O)C4=C(C)N(CC(C)(C)O)N(C4=O)c5ccccc5)nc3)ccnc2c1

> <pd_targets>
{LCK,FES,FLT3,BMX,CSF1R,RET,KIT,KDR,INSR,MET,AKT2,JAK1,AKT1,MST1R,BTK,PIM2,AURKA,IGF1R,BLK,RPS6KB1,TEK,MAPK3,JAK3,RPS6KA5,CDK5,CDK5R1,PIM1,JAK2,AURKB,ABL1,SRC,FGR,LYN,MAPK14,MAPK9,CSK,PRKACA,FGFR1,ITK
}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","AGC protein kinase group","CAMK protein kinase group","Other protein kinase group","CMGC protein kinase group","Tyrosine protein kinase Src f
amily","Tyrosine protein kinase Fer family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Ret family","Tyrosine protein kinase VEGFR family","Tyr
osine protein kinase InsR family","Tyrosine protein kinase Met family","AGC protein kinase AKT family","Tyrosine protein kinase JakA family","CAMK protein kinase PIM family","Other protein kinase AUR 
family","AGC protein kinase RSK family","Tyrosine protein kinase Tie family","CMGC protein kinase MAPK family","CMGC protein kinase CDK family","Tyrosine protein kinase Abl family","Tyrosine protein k
inase Csk family","AGC protein kinase PKA family","Tyrosine protein kinase FGFR family","AGC protein kinase p70 subfamily","CMGC protein kinase ERK1","AGC protein kinase MSK subfamily","CMGC protein k
inase CDC2 subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase JNK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",
MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Akt (Protein kinase B","PKB) family","PIM family","Other protein kinases","RSK family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase
 A (PKA) family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Aurora kinase (Aur) family","p70 subfamily","ERK subfamily","MSK subfamily","p38 subfamily","JNK subfamily"
,"Src family","Fer family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Tec family","Type XIV RTKs: RET","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type II R
TKs: Insulin receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Janus kinase (JakA) family","Type XII RTKs: TIE family of angiopoietin receptors","Abl family","Csk family"
,"Type V RTKs: FGF (fibroblast growth factor) receptor family"}

> <pathway_reactome>
{Disease,"Developmental Biology","Signal Transduction",Metabolism,"Gene expression (Transcription)","Immune System","Cell Cycle","Infectious disease","Nervous system development","Signaling by Recepto
r Tyrosine Kinases","Metabolism of lipids","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Intracellular signaling by second messe
ngers","Cytokine Signaling in Immune system","MTOR signalling","MAPK family signaling cascades","Innate Immune System",Mitotic,"Adaptive Immune System","HIV Infection","Axon guidance","Signaling by In
sulin receptor","Phospholipid metabolism","Generic Transcription Pathway","Signaling by KIT in disease","Signaling by VEGF","PIP3 activates AKT signaling","Interferon Signaling","Signaling by MST1","L
eishmania infection","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","mTORC1-mediated signalling","MAPK1/MAPK3 signaling","Toll-like Receptor Cascades","Signaling by Interleukins",
"FLT3 signaling in disease","Mitotic G1 phase and G1/S transition","M Phase","Signaling by NTRKs","Oncogenic MAPK signaling","Mitotic G2-G2/M phases","Signaling by FGFR in disease","TCR signaling","Ho
st Interactions of HIV factors","Semaphorin interactions","Insulin receptor signalling cascade","PI Metabolism","Transcriptional Regulation by VENTX","RET signaling","Drug resistance of KIT mutants","
VEGFA-VEGFR2 Pathway","Negative regulation of the PI3K/AKT network","Antiviral mechanism by IFN-stimulated genes","Transcriptional Regulation by TP53","Parasite infection","IGF1R signaling cascade","T
ranscriptional regulation by RUNX1","RAF/MAP kinase cascade","Toll Like Receptor 5 (TLR5) Cascade","Interleukin-2 family signaling","Signaling by FLT3 ITD and TKD mutants","G1 Phase","Mitotic Metaphas
e and Anaphase","Signaling by NTRK1 (TRKA)","Leishmania parasite growth and survival","Signaling by RAS mutants","G2/M Transition","Signaling by FGFR1 in disease","Generation of second messenger molec
ules","The role of Nef in HIV-1 replication and disease pathogenesis","CRMPs in Sema3A signaling","IRS-mediated signalling","Synthesis of PIPs at the plasma membrane","Dasatinib-resistant KIT mutants"
,"VEGFR2 mediated cell proliferation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Sema4D in semaphorin signaling","ISG15 antiviral mechanism","Regulation of TP53 Activity","Leishmania phagocytos
is","IRS-related events triggered by IGF1R","RUNX1 regulates transcription of genes involved in BCR signaling","MyD88 cascade initiated on plasma membrane","Interleukin-15 signaling","STAT5 activation
 downstream of FLT3 ITD mutants","Cyclin D associated events in G1","Mitotic Anaphase","Signalling to ERKs","Anti-inflammatory response favouring Leishmania parasite infection","Signaling downstream o
f RAS mutants","Centrosome maturation","FGFR1 mutant receptor activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","PI3K Cascade","Sema4D mediat
ed inhibition of cell attachment and migration","Regulation of TP53 Expression and Degradation","FCGR3A-mediated phagocytosis","Regulation of TP53 Activity through Phosphorylation","MAP kinase activat
ion","Separation of Sister Chromatids","Signalling to RAS","FCGR3A-mediated IL10 synthesis","Loss of proteins required for interphase microtubule organization from the centrosome","Signaling by activa
ted point mutants of FGFR1","Nef Mediated CD4 Down-regulation","PKB-mediated events","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","Loss of N
lp from mitotic centrosomes","PDE3B signalling","ERK/MAPK targets","CREB phosphorylation","Activation of the AP-1 family of transcription factors","ERKs are inactivated"}

> <broad_targets>
{MET}

> <broad_moa>
{"MET inhibitor"}

> <synonyms>
{AMG-458,AMG458,"AMG 458",913376-83-7,913376837,"913376 83 7",UNII-4535RW5Y3A,UNII4535RW5Y3A,"UNII 4535RW5Y3A",4535RW5Y3A,C30H29N5O5,"Substituted Pyrazolone, 17","AMG-458 (c-Met)","AMG458 (cMet)","AMG
 458 (c Met)",cc-602,cc602,"cc 602",MLS006010963,S2747}

> <pdid>
PD010686

> <targets>
{c-Met}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{24764449}

$$$$
UTKinase_V5
  SciTegic11012413002D

 43 46  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -2.5998    3.0004    0.0000 O   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   19.3737    7.5118    0.0000 F   0  0
   19.3788    6.0118    0.0000 C   0  0
   20.6804    5.2663    0.0000 C   0  0
   20.6856    3.7663    0.0000 C   0  0
   19.3891    3.0119    0.0000 C   0  0
   18.0875    3.7573    0.0000 C   0  0
   16.7888    3.0051    0.0000 C   0  0
   15.4875    3.7529    0.0000 O   0  0
   14.1888    3.0006    0.0000 C   0  0
   14.1940    1.5006    0.0000 C   0  0
   12.8975    0.7461    0.0000 C   0  0
   11.5958    1.4916    0.0000 C   0  0
   10.2972    0.7393    0.0000 N   0  0
    8.9958    1.4870    0.0000 C   0  0
    8.9958    2.9870    0.0000 N   0  0
    7.6968    3.7370    0.0000 C   0  0
    6.3978    2.9870    0.0000 N   0  0
    6.3978    1.4870    0.0000 C   0  0
    5.0987    0.7370    0.0000 C   0  0
    5.0987   -0.7630    0.0000 C   0  0
    6.3978   -1.5130    0.0000 C   0  0
    6.4009   -3.0138    0.0000 N   0  0
    7.7017   -3.7624    0.0000 C   0  0
    8.9994   -3.0101    0.0000 O   0  0
    7.7048   -5.2632    0.0000 C   0  0
    9.0049   -6.0113    0.0000 C   0  0
    7.6968   -0.7630    0.0000 C   0  0
    7.6968    0.7370    0.0000 C   0  0
   11.5907    2.9916    0.0000 C   0  0
   12.8871    3.7461    0.0000 C   0  0
   12.8820    5.2461    0.0000 Cl  0  0
   18.0824    5.2574    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  2  0
  8 11  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  1  0
 34 35  2  0
 34 36  1  0
 36 37  2  0
 32 38  1  0
 38 39  2  0
 39 25  1  0
 39 29  1  0
 23 40  1  0
 40 41  2  0
 41 20  1  0
 41 42  1  0
 17 43  2  0
 43 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28587

> <plate>
Kinase v5-2

> <well>
F07

> <supplier_cmpd_name>
AST-1306

> <ctcr_id>
3479

> <supplier_cmpd_id>
S2185

> <smiles>
Cc1ccc(cc1)S(=O)(=O)O.Fc2cccc(COc3ccc(Nc4ncnc5ccc(NC(=O)C=C)cc45)cc3Cl)c2

> <pd_targets>
{ERBB2,ERBB4,EGFR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Neuronal System","Signal Transduction","Nervous system development","Transmission across Chemical Synapses","Signaling by GPCR","Axon guidance","Neurotransmitter receptors an
d postsynaptic signal transmission","GPCR downstream signalling","Semaphorin interactions","Activation of NMDA receptors and postsynaptic events","G alpha (q) signalling events","Sema4D in semaphorin 
signaling","Post NMDA receptor activation events","Gastrin-CREB signalling pathway via PKC and MAPK","Sema4D induced cell migration and growth-cone collapse","Long-term potentiation","EGFR Transactiva
tion by Gastrin"}

> <broad_targets>
{EGFR,ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{1050500-29-2,1050500292,"Allitinib tosylate","AST-1306 TsOH","AST1306 TsOH",AST-6,AST6,"AST-1306 (TsOH)","AST1306 (TsOH)","AST 1306 tosylate",cc-284,cc284,MLS006011282,SCHEMBL230864,AST-6/,AST6/,DTXS
ID30648510,HMS3655D08,HMS3672E13,BCP02099,EX-A2292,EXA2292,ABP000605,s2185,AKOS027288723,CCG-270255,CCG270255,CS-,CS,T6331,S2185,AST-1306}

> <pdid>
PD038945

> <targets>
{EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{25027665}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    7.7938   -3.0046    0.0000 C   0  0
    6.4946   -3.7543    0.0000 O   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    3.8888   -5.2533    0.0000 C   0  0
    2.5875   -5.9994    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968   -1.5004    0.0000 N   0  0
   -5.1945   -3.0005    0.0000 C   0  0
   -6.4924   -3.7525    0.0000 C   0  0
   -7.7926   -3.0046    0.0000 O   0  0
   -7.7950   -1.5046    0.0000 C   0  0
   -6.4971   -0.7525    0.0000 C   0  0
   -6.4996    0.7475    0.0000 C   0  0
   -2.5981    3.0007    0.0000 N   0  0
   -3.8983    3.7488    0.0000 C   0  0
   -3.9007    5.2488    0.0000 C   0  0
   -2.6029    6.0009    0.0000 O   0  0
   -1.3026    5.2529    0.0000 C   0  0
   -1.3003    3.7529    0.0000 C   0  0
    0.0000    3.0050    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
  6 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 14  1  0
 19 20  2  0
 20 11  1  0
 17 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 26 27  1  0
 15 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 28  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28588

> <plate>
Kinase v5-2

> <well>
F09

> <supplier_cmpd_name>
AZD8055

> <ctcr_id>
4959

> <supplier_cmpd_id>
S1555

> <smiles>
COc1ccc(cc1CO)c2ccc3c(nc(nc3n2)N4CCOCC4C)N5CCOCC5C

> <pd_targets>
{PIK3CA,MTOR,PIK3R1,MAPKAP1,MLST8,RICTOR,RPTOR,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Transferase,Kinase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","Atypical protein kinase group","Voltage-gated potassium channel","Atypical protein kinase PI
KK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels","Kinases (EC 2.7.x.x)","Voltage-gated ion channels","Lipid modifying kinases",Atypical,"Potassium channels",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidy
l inositol 3' kinase-related kinases (PIKK) family","Voltage-gated potassium channels","FRAP subfamily"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Muscle contraction","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Cardiac conduction
","Signaling by FGFR in disease","Generic Transcription Pathway","Phase 3 - rapid repolarisation","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","FGFR1 mutant receptor activation
","Regulation of TP53 Activity","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{SCHEMBL1219191,CHEMBL2140640,HMS3265A15,HMS3265A16,HMS3265B15,HMS3265B16,HMS3655K03,HMS3744M21,AKOS026750238,NCGC00389372-02,NCGC0038937202,AK109550,LS-15122,LS15122,FT-0660381,FT0660381,S1555,AZD805
5}

> <pdid>
PD003359

> <targets>
{mTOR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{44200436}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 N   0  0
   -6.4954    0.7438    0.0000 N   0  0
   -7.7969    1.4897    0.0000 C   0  0
   -9.0936    0.7355    0.0000 C   0  0
   -9.0888   -0.7645    0.0000 O   0  0
   -7.7874   -1.5103    0.0000 C   0  0
   -6.4907   -0.7562    0.0000 C   0  0
   -3.9038    5.2491    0.0000 N   0  0
   -2.6072    6.0033    0.0000 C   0  0
   -2.6120    7.5033    0.0000 C   0  0
   -3.9134    8.2492    0.0000 O   0  0
   -5.2100    7.4951    0.0000 C   0  0
   -5.2053    5.9951    0.0000 C   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2985    3.7517    0.0000 F   0  0
   -1.2993    3.7504    0.0000 F   0  0
   -0.0007    4.5008    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 12 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
 10 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
  4 26  1  0
 26 27  1  0
 26 28  1  0
 26 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28589

> <plate>
Kinase v5-2

> <well>
F11

> <supplier_cmpd_name>
BKM120 (NVP-BKM120)

> <ctcr_id>
6201

> <supplier_cmpd_id>
S2247

> <smiles>
Nc1cc(c(cn1)c2cc(nc(n2)N3CCOCC3)N4CCOCC4)C(F)(F)F

> <pd_targets>
{PIK3CD,PIK3CG,PI4KB,PIK3R1,PIK3CA,MTOR,PIK3C3,PIK3CB,PIK3C2B,PRKDC,PIK3R5,PIK3R2,PIK3R3}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Glycerophospholipid turnover","Lipid modifying kinases","Phosphatidylinositol kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","1-phosphatidyl
inositol 4-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Phosphatidylinositol 3-kinase family","Phosphatidylinositol-4-phosphate 3-kinase family","FRAP subfamily","Ot
her PIKK family kinases"}

> <pathway_reactome>
{"Immune System",Metabolism,Disease,"Gene expression (Transcription)","Signal Transduction","Cytokine Signaling in Immune system","Metabolism of lipids","Diseases of signal transduction by growth fact
or receptors and second messengers","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Signaling by Interleukins","Phospholipid metabolism","Signaling b
y FGFR in disease","Generic Transcription Pathway","Signaling by Insulin receptor","Cytosolic sensors of pathogen-associated DNA",Interleukin-3,"Interleukin-5 and GM-CSF signaling","PI Metabolism","Si
gnaling by FGFR1 in disease","Transcriptional Regulation by TP53","Insulin receptor signalling cascade","STING mediated induction of host immune responses","Interleukin receptor SHC signaling","Synthe
sis of PIPs at the plasma membrane","Synthesis of PIPs at the Golgi membrane","FGFR1 mutant receptor activation","Regulation of TP53 Activity","IRS-mediated signalling","IRF3-mediated induction of typ
e I IFN","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation","PI3K Cascade","Regulation of TP53 Degradation"}

> <broad_targets>
{PIK3CA,PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{"KM120 (NVPBKM120",NCGC00262604-01,NCGC0026260401,NCGC00262604-08,NCGC0026260408,AC-32077,AC32077,Buparlisib,944396-07-0,944396070,NVP-BKM120,NVPBKM120,BKM120,"5-(2,6-dimorpholinopyrimidin-4-yl)-4-(t
rifluoromethyl)pyridin-2-amine","5(2,6dimorpholinopyrimidin4yl)4(trifluoromethyl)pyridin2amine",NVP-BKM-120,BKM-120,"BKM 120",1202777-78-3,1202777783,UNII-0ZM2Z182GD,UNII0ZM2Z182GD,"NVP-BKM 120","NVPB
KM 120",BKM12,T1827,S2247,"BKM120 (NVP-BKM120)","BKM120 (NVP-BKM120, Buparlisib)"}

> <pdid>
PD010807

> <targets>
{PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{16654980}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 O   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 C   0  0
   -4.8211    4.6570    0.0000 C   0  0
   -6.3142    4.8094    0.0000 C   0  0
   -7.0437    6.1054    0.0000 S   0  0
   -8.5106    5.7921    0.0000 C   0  0
   -9.6263    6.7947    0.0000 O   0  0
   -8.6660    4.3002    0.0000 N   0  0
   -7.2950    3.6914    0.0000 C   0  0
   -6.9730    2.2264    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12  8  2  0
 10 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 14  1  0
 19 20  2  0
M  END
> <name>
UTKinase_V5

> <id>
28590

> <plate>
Kinase v5-2

> <well>
F13

> <supplier_cmpd_name>
CAY10505

> <ctcr_id>
7730

> <supplier_cmpd_id>
S2682

> <smiles>
Fc1ccc(cc1)c2oc(cc2)\C=C/3SC(=O)NC3=O

> <pd_targets>
{IGF1R}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase InsR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","IGF1R signaling cascade","IRS-related events triggered by IGF1R"}

> <broad_targets>
{PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{CAY10505,1218777-13-9,1218777139,CHEMBL590022,"(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione","(E)5((5(4fluorophenyl)furan2yl)methylene)thiazolidine2,4dione",SCHEMBL13479680,S
CHEMBL16416080,DTXSID60360955,ZINC973810,328960-84-5,328960845,EX-A1070,EXA1070,ABP000112,BDBM50308349,STK201819,AKOS000409173,BCP9000494,CC,S2682}

> <pdid>
PD019843

> <targets>
{PI3K}

> <classes>
{}

> <pubchem_cids>
{1204893}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 35  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.6011   -3.0008    0.0000 N   0  0
   -1.3034   -3.7547    0.0000 C   0  0
    0.0488   -3.7791    0.0000 C   0  0
    0.7466   -4.8860    0.0000 N   0  0
    0.4044   -6.4977    0.0000 C   0  0
   -1.0330   -6.5013    0.0000 C   0  0
   -0.5907   -4.9503    0.0000 C   0  0
    1.1704   -4.4619    0.0000 C   0  0
    2.3234   -4.6798    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1968   -1.5004    0.0000 C   0  0
   -6.5492   -0.8815    0.0000 N   0  0
   -7.5504   -1.9974    0.0000 C   0  0
   -9.0504   -1.9998    0.0000 C   0  0
   -9.7983   -3.3000    0.0000 C   0  0
   -9.0462   -4.5979    0.0000 C   0  0
   -7.5462   -4.5955    0.0000 C   0  0
   -6.7983   -3.2953    0.0000 C   0  0
   -5.3323   -2.9815    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 12  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
 10 20  1  0
 20  5  1  0
 20 21  2  0
 21  2  1  0
  9 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 29 30  1  0
 30 22  2  0
M  END
> <name>
UTKinase_V5

> <id>
28591

> <plate>
Kinase v5-2

> <well>
F15

> <supplier_cmpd_name>
CHIR-124

> <ctcr_id>
6676

> <supplier_cmpd_id>
S2683

> <smiles>
Clc1ccc2NC(=O)C(=C(NC3CN4CCC3CC4)c2c1)c5[nH]c6ccccc6n5

> <pd_targets>
{CHEK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase CAMK1 family","CAMK protein kinase CHK1 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","CAMK-like (CAMKL) family","CHK1 subfamily"}

> <pathway_reactome>
{"DNA Repair","DNA Double-Strand Break Repair","Homology Directed Repair","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Ho
mologous DNA Pairing and Strand Exchange","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{CHEK1}

> <broad_moa>
{"CHK inhibitor"}

> <synonyms>
{HIR12,SCHEMBL15105373,HMS3656F13,FT-0771009,FT0771009,T6350,S2683,CHIR-124}

> <pdid>
PD005860

> <targets>
{Chk}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{135674135}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0875    3.7680    0.0000 F   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Cl  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6016   -2.9971    0.0000 O   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4996    0.0000 C   0  0
   -3.9117   -8.2482    0.0000 N   0  0
   -3.9170   -9.7482    0.0000 C   0  0
   -5.2186  -10.4937    0.0000 C   0  0
   -6.5150   -9.7392    0.0000 C   0  0
   -6.5099   -8.2392    0.0000 C   0  0
   -5.2082   -7.4937    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 16 18  2  0
 18 11  1  0
  9 19  2  0
 19  5  1  0
 19 20  1  0
 20 21  2  0
 21  3  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  2  3
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28592

> <plate>
Kinase v5-2

> <well>
F17

> <supplier_cmpd_name>
Dacomitinib (PF299804,PF-00299804)

> <ctcr_id>
3050

> <supplier_cmpd_id>
S2727

> <smiles>
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCN4CCCCC4

> <pd_targets>
{EGFR,ERBB2,LCK,ERBB4,SRC,ERBB3,JAK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase JakA family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type I RTKs: ErbB (epidermal growth factor) recept
or family","Src family","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology",Disease,"Neuronal System","Immune System","Signaling by GPCR","Nervous system development","Infectious disease","Transmission across Chemical Synapses","
Signaling by Receptor Tyrosine Kinases","Cytokine Signaling in Immune system","GPCR downstream signalling","Axon guidance","HIV Infection","Neurotransmitter receptors and postsynaptic signal transmiss
ion","Signaling by NTRKs","Signaling by Interleukins","G alpha (q) signalling events","Semaphorin interactions","Host Interactions of HIV factors","Activation of NMDA receptors and postsynaptic events
","Signaling by NTRK1 (TRKA)","Interleukin-2 family signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Sema4D in semaphorin signaling","The role of Nef in HIV-1 replication and disease pat
hogenesis","Post NMDA receptor activation events","Signalling to ERKs","Interleukin-15 signaling","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone collapse","Nef-mediat
es down modulation of cell surface receptors by recruiting them to clathrin adapters","Long-term potentiation","Signalling to RAS","Nef Mediated CD4 Down-regulation","p38MAPK events"}

> <broad_targets>
{EGFR,ERBB2,ERBB4}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{PF299,PF-299804,PF299804,"PF 299804",SCHEMBL25637,CHEMBL2139591,HMS3656P17,HMS3672E09,AKOS026750507,NCGC00263185-01,NCGC0026318501,"NCGC00263185 01",AK317481,FT-0696499,FT0696499,"FT 0696499",Q271633
05,S2727,"Dacomitinib (PF299804,PF-00299804)","Dacomitinib (PF299804, PF299)"}

> <pdid>
PD010693

> <targets>
{EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{57519532}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  0  0            999 V2000
    8.5440   -1.7998    0.0000 C   0  0
    9.3008   -3.0949    0.0000 C   0  0
   10.8008   -3.0866    0.0000 O   0  0
    8.5568   -4.3983    0.0000 C   0  0
    9.3135   -5.6934    0.0000 O   0  0
    7.0560   -4.4066    0.0000 N   0  0
    6.3105   -5.7083    0.0000 C   0  0
    4.8105   -5.7135    0.0000 C   0  0
    4.0559   -4.4171    0.0000 N   0  0
    2.5551   -4.4192    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6923   -4.0811    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 N   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -6.4995    3.7442    0.0000 N   0  0
   -5.1969    1.4963    0.0000 N   0  0
   -3.8967    0.7484    0.0000 C   0  0
    2.5987    1.5004    0.0000 N   0  0
    3.8991    0.7525    0.0000 C   0  0
    5.1969    1.5046    0.0000 C   0  0
    5.1945    3.0046    0.0000 O   0  0
    3.8943    3.7525    0.0000 C   0  0
    2.5964    3.0004    0.0000 C   0  0
    4.8014   -3.1154    0.0000 C   0  0
    6.3014   -3.1102    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 19 11  2  0
 19 20  1  0
 16 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 24 26  1  0
 26 27  2  0
 27 21  1  0
 14 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 28  1  0
  9 34  1  0
 34 35  1  0
 35  6  1  0
M  END
> <name>
UTKinase_V5

> <id>
28593

> <plate>
Kinase v5-2

> <well>
F19

> <supplier_cmpd_name>
GDC-0980 (RG7422)

> <ctcr_id>
4004

> <supplier_cmpd_id>
S2696

> <smiles>
CC(O)C(=O)N1CCN(Cc2sc3c(nc(nc3c2C)c4cnc(N)nc4)N5CCOCC5)CC1

> <pd_targets>
{PIK3CA,PIK3C3,PIK3CD,PIK3CG,SYK,PIK3C2B,PRKDC,PIK3CB,FGR,MAP3K9,MTOR,PIK3C2A,PIK3R1,PIK3R2,PIK3R3,PIK3R5}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","TK protein kinase group","Atypical protein kinase group","TKL protein kinase group","Tyrosine protein kinase Syk family","Atypical protein kinase PIKK fami
ly","Tyrosine protein kinase Src family","TKL protein kinase MLK family","TKL protein kinase MLK subfamily","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","Receptor kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidylinositol 3-ki
nase family","TK: Tyrosine kinase","Phosphatidylinositol-4-phosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","TKL: Tyrosine kinase-like","Non-receptor tyrosine
 kinases (nRTKs)","Other PIKK family kinases","Mixed Lineage Kinase (MLK) family","FRAP subfamily","Syk family","Src family","MLK subfamily"}

> <pathway_reactome>
{Disease,"Signal Transduction","Immune System",Metabolism,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Ty
rosine Kinases","Cytokine Signaling in Immune system","Metabolism of lipids","Infectious disease","Innate Immune System","RNA Polymerase II Transcription","Signaling by FGFR in disease","Signaling by 
Insulin receptor","Signaling by Interleukins","Phospholipid metabolism","Leishmania infection","Cytosolic sensors of pathogen-associated DNA","Generic Transcription Pathway","Signaling by FGFR1 in dis
ease","Insulin receptor signalling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","PI Metabolism","Leishmania parasite growth and survival","STING mediated induction of host immune respon
ses","Transcriptional Regulation by TP53","FGFR1 mutant receptor activation","IRS-mediated signalling","Interleukin receptor SHC signaling","Synthesis of PIPs at the plasma membrane","Anti-inflammator
y response favouring Leishmania parasite infection","IRF3-mediated induction of type I IFN","Regulation of TP53 Activity","Synthesis of PIPs at the early endosome membrane","Signaling by cytosolic FGF
R1 fusion mutants","PI3K Cascade","FCGR3A-mediated IL10 synthesis","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{FGR,MAP3K9,MTOR,PIK3CA,PIK3CB,PIK3CD,PIK3CG,SYK}

> <broad_moa>
{"mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{"DC0980 (RG7422",SCHEMBL466298,CHEBI:93753,HMS3656D15,HMS3672M03,AKOS026750262,NCGC00387831-03,NCGC0038783103,AC-28439,AC28439,AK175458,Q27165444,S2696,"GDC-0980 (RG7422)"}

> <pdid>
PD010882

> <targets>
{mTOR,PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{66694608}

$$$$
UTKinase_V5
  SciTegic11012413002D

 61 68  0  0  0  0            999 V2000
    1.7729   -0.8693    0.0000 C   0  0
    2.3878   -1.6578    0.0000 C   0  0
    3.8744   -1.4513    0.0000 C   0  0
    4.7936   -2.6366    0.0000 C   0  0
    6.2798   -2.4333    0.0000 C   0  0
    7.1972   -3.6211    0.0000 N   0  0
    8.6847   -3.4216    0.0000 C   0  0
    9.2581   -2.0355    0.0000 N   0  0
   10.7452   -1.8391    0.0000 C   0  0
   11.6588   -3.0288    0.0000 C   0  0
   11.0864   -4.4099    0.0000 C   0  0
    9.5983   -4.6112    0.0000 N   0  0
   11.9083   -5.6656    0.0000 C   0  0
   11.3761   -7.0672    0.0000 N   0  0
    9.9776   -7.6096    0.0000 C   0  0
    9.7482   -9.0920    0.0000 C   0  0
   10.9171  -10.0319    0.0000 C   0  0
   12.3156   -9.4895    0.0000 C   0  0
   12.5451   -8.0071    0.0000 C   0  0
   13.7998   -7.1864    0.0000 N   0  0
   13.4065   -5.7389    0.0000 C   0  0
   14.3469   -4.5693    0.0000 C   0  0
   15.8373   -4.6872    0.0000 C   0  0
   16.6866   -3.4507    0.0000 C   0  0
   16.0405   -2.0970    0.0000 C   0  0
   16.8928   -0.8617    0.0000 O   0  0
   18.3880   -0.9811    0.0000 C   0  0
   14.5451   -1.9797    0.0000 C   0  0
   13.6958   -3.2161    0.0000 C   0  0
   13.8958   -0.6266    0.0000 C   0  0
   14.7430    0.6113    0.0000 O   0  0
   12.3994   -0.5113    0.0000 N   0  0
   11.7502    0.8418    0.0000 C   0  0
   10.2547    0.9592    0.0000 C   0  0
    9.4054   -0.2772    0.0000 F   0  0
    9.6086    2.3129    0.0000 C   0  0
   10.4579    3.5493    0.0000 C   0  0
   11.9533    3.4320    0.0000 C   0  0
   12.5994    2.0783    0.0000 C   0  0
   14.0948    1.9611    0.0000 F   0  0
    6.8467   -1.0445    0.0000 C   0  0
    8.3332   -0.8378    0.0000 O   0  0
    8.8981    0.5517    0.0000 C   0  0
    5.9275    0.1409    0.0000 C   0  0
    4.4413   -0.0625    0.0000 C   0  0
    3.5216    1.1234    0.0000 N   0  0
    4.0863    2.5131    0.0000 C   0  0
    3.1652    3.6970    0.0000 C   0  0
    1.6794    3.4913    0.0000 C   0  0
    1.1146    2.1016    0.0000 C   0  0
    2.0357    0.9177    0.0000 C   0  0
    0.7578    4.6757    0.0000 N   0  0
    1.3202    6.0664    0.0000 C   0  0
    0.3973    7.2488    0.0000 C   0  0
   -1.0882    7.0407    0.0000 N   0  0
   -1.6508    5.6501    0.0000 C   0  0
   -0.7278    4.4677    0.0000 C   0  0
   -2.0117    8.2237    0.0000 S   0  0
   -3.4972    8.0151    0.0000 C   0  0
   -1.4501    9.6146    0.0000 O   0  0
   -2.9353    9.4057    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 14  1  0
 19 20  2  0
 20 21  1  0
 21 13  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  1  0
 25 28  1  0
 28 29  2  0
 29 22  1  0
 28 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 34 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 39 33  1  0
 39 40  1  0
  5 41  2  0
 41 42  1  0
 42 43  1  0
 41 44  1  0
 44 45  2  0
 45  3  1  0
 45 46  1  0
 46 47  1  0
 47 48  1  0
 48 49  1  0
 49 50  1  0
 50 51  1  0
 51 46  1  0
 49 52  1  0
 52 53  1  0
 53 54  1  0
 54 55  1  0
 55 56  1  0
 56 57  1  0
 57 52  1  0
 55 58  1  0
 58 59  1  0
 58 60  2  0
 58 61  2  0
M  END
> <name>
UTKinase_V5

> <id>
28594

> <plate>
Kinase v5-2

> <well>
F21

> <supplier_cmpd_name>
GSK1904529A

> <ctcr_id>
5764

> <supplier_cmpd_id>
S1093

> <smiles>
CCc1cc(Nc2nccc(n2)c3n4ccccc4nc3c5ccc(OC)c(c5)C(=O)Nc6c(F)cccc6F)c(OC)cc1N7CCC(CC7)N8CCN(CC8)[S](C)(=O)=O

> <pd_targets>
{INSR,IGF1R,AURKB,MAPK14,FER,FRK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","CMGC protein kinase group","Tyrosine protein kinase InsR family","Other protein kinase AUR family","CMGC protein
 kinase MAPK family","Tyrosine protein kinase Fer family","Tyrosine protein kinase Src family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Other protein kinases","Mitogen-activated prot
ein kinases (MAP kinases)","Receptor tyrosine kinases (RTKs)","Aurora kinase (Aur) family","p38 subfamily","Non-receptor tyrosine kinases (nRTKs)","Type II RTKs: Insulin receptor family","Fer family",
"Src family"}

> <pathway_reactome>
{"Signal Transduction","Cell Cycle","Immune System","Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases",Mitotic,"Innate Immune System","PIP3 activates AKT signaling
","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","M Phase","Toll-like Receptor Cascades","Signaling by SCF-KIT","Negative regulation of the PI3K/AKT network","IGF1R signaling casc
ade","Mitotic Metaphase and Anaphase","Toll Like Receptor 5 (TLR5) Cascade","PTEN Regulation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","IRS-related events triggered by IGF1R","Mitotic Anaphase
","MyD88 cascade initiated on plasma membrane","Regulation of PTEN stability and activity","Separation of Sister Chromatids","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinas
es","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{IGF1R,INSR}

> <broad_moa>
{"IGF-1 inhibitor","insulin growth factor receptor inhibitor","insulin receptor ligand"}

> <synonyms>
{GSK1904529A,1089283-49-7,1089283497,GSK-1904529A,"GSK 1904529A",CHEMBL466397,PubChem22431,cc-35,cc35,MLS006010966,SCHEMBL309890,C44H47F2N9O5S,CHEBI:91401,DTXSID70648776,EX-A008,EXA008,HMS3295G13,HMS3
654G19,AMY24202,AOB87389,"IGF-1R inhibitor GS1904529A","IGF1R inhibitor GS1904529A",ABP000158,BD,T6003,S1093}

> <pdid>
PD011145

> <targets>
{IGF-1R}

> <classes>
{}

> <pubchem_cids>
{25124816}

$$$$
UTKinase_V5
  SciTegic11012413002D

 11 12  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  2  1  0
 11  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28595

> <plate>
Kinase v5-2

> <well>
H03

> <supplier_cmpd_name>
3-Methyladenine

> <ctcr_id>
1181

> <supplier_cmpd_id>
S2767

> <smiles>
Cn1cnc(N)c2ncnc12

> <pd_targets>
{ADORA2A,ADORA1,ADORA2B}

> <pathway_gtopdb>
{"Membrane receptor","Family A G protein-coupled receptor","Small molecule receptor (family A GPCR)","Nucleotide-like receptor (family A GPCR)","Adenosine receptor"}

> <pathway_chembl>
{Receptors,"G protein-coupled receptors","Adenosine receptors"}

> <pathway_reactome>
{Disease,"Signal Transduction","Infectious disease","Signaling by GPCR","Leishmania infection","GPCR ligand binding","Leishmania parasite growth and survival","Class A/1 (Rhodopsin-like receptors)","A
nti-inflammatory response favouring Leishmania parasite infection","Nucleotide-like (purinergic) receptors","ADORA2B mediated anti-inflammatory cytokines production","Adenosine P1 receptors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{3Methyladenine,3-MA,3MA,S2767,T1879,SY-3MA,3-Methyladenine}

> <pdid>
PD006476

> <targets>
{PI3K,autophagy,Autophagy,"Endogenous Metabolite",Mitophagy}

> <classes>
{PI3K/Akt/mTOR,Autophagy,Metabolic Enzyme/Protease}

> <pubchem_cids>
{1673}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 37  0  0  0  0            999 V2000
    1.3000    2.2500    0.0000 C   0  0
    1.3000    0.7500    0.0000 S   0  0
    0.0007    0.0004    0.0000 O   0  0
    2.5993    0.0004    0.0000 O   0  0
    1.3000   -0.7500    0.0000 O   0  0
   11.5904    0.3824    0.0000 O   0  0
   12.8907    1.1301    0.0000 C   0  0
   12.8928    2.6309    0.0000 N   0  0
   11.5946    3.3840    0.0000 C   0  0
   11.5946    4.8840    0.0000 C   0  0
   10.2956    5.6340    0.0000 C   0  0
    8.9965    4.8840    0.0000 C   0  0
    8.9965    3.3840    0.0000 C   0  0
   10.2956    2.6340    0.0000 C   0  0
    7.6963    5.6345    0.0000 C   0  0
    8.9090    6.4540    0.0000 C   0  0
    8.4439    7.8801    0.0000 C   0  0
    6.9439    7.8784    0.0000 C   0  0
    6.4819    6.4513    0.0000 C   0  0
    6.3982    4.8813    0.0000 C   0  0
    5.1007    4.1286    0.0000 N   0  0
   14.1889    0.3770    0.0000 C   0  0
   15.4881    1.1270    0.0000 C   0  0
   16.7871    0.3769    0.0000 C   0  0
   16.7870   -1.1231    0.0000 C   0  0
   15.4880   -1.8730    0.0000 N   0  0
   14.1890   -1.1230    0.0000 C   0  0
   12.8908   -1.8761    0.0000 N   0  0
   12.8929   -3.3769    0.0000 C   0  0
   11.5947   -4.1300    0.0000 C   0  0
   11.5947   -5.6301    0.0000 C   0  0
   10.2957   -6.3801    0.0000 C   0  0
    8.9966   -5.6301    0.0000 N   0  0
    8.9965   -4.1301    0.0000 C   0  0
   10.2956   -3.3801    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  2  0
  2  5  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 12 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 15  1  0
 15 20  1  0
 20 21  3  0
  7 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28596

> <plate>
Kinase v5-2

> <well>
H05

> <supplier_cmpd_name>
Apatinib (YN968D1)

> <ctcr_id>
4550

> <supplier_cmpd_id>
S2221

> <smiles>
CS(=O)(=O)O.O=C(Nc1ccc(cc1)C2(CCCC2)C#N)c3cccnc3NCc4ccncc4

> <pd_targets>
{KDR,KIT,RET,CSK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Cs
k family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type IV RTKs: VEGF (vascular endothelial growth fa
ctor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIV RTKs: RET","Csk family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Developmental Biology","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Nervous system devel
opment","Signaling by VEGF","Signaling by KIT in disease","Axon guidance","Oncogenic MAPK signaling","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","RET signaling","Signaling by RAS mutants",
"VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","Signaling downstream of RAS mutants"}

> <broad_targets>
{CSK,KDR,KIT,RET}

> <broad_moa>
{"RET tyrosine kinase inhibitor"}

> <synonyms>
{Apatinib,"Apatinib Mesylate",1218779-75-9,1218779759,"1218779 75 9","Rivoceranib mesylate",YN968D1,YN-968D1,"YN 968D1",UNII-TK02X14ASJ,UNIITK02X14ASJ,"UNII TK02X14ASJ",TK02X14ASJ,Apatinib?mesylate,"A
litan (TN)","Apatinib (YN968D1)","Apatinib - YN968D1","Apatinib  YN968D1","Apatinib   YN968D1","Rivoceranib mesylate (USAN)",cc-605,cc605,"cc 605",MLS006011286,CHEMB,T5153,T2582,S2221,"Apatinib mesyla
te"}

> <pdid>
PD057121

> <targets>
{VEGFR,c-RET}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{45139106}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1953   -1.5031    0.0000 N   0  0
   -5.1932   -3.0039    0.0000 C   0  0
   -3.8915   -3.7495    0.0000 C   0  0
   -3.8863   -5.2495    0.0000 C   0  0
   -2.5855   -5.9981    0.0000 N   0  0
   -2.5825   -7.4989    0.0000 C   0  0
   -3.8802   -8.2512    0.0000 O   0  0
   -1.2817   -8.2475    0.0000 C   0  0
   -1.2764   -9.7476    0.0000 C   0  0
    0.0252  -10.4931    0.0000 C   0  0
    1.3216   -9.7386    0.0000 C   0  0
    1.3165   -8.2386    0.0000 C   0  0
    0.0149   -7.4931    0.0000 C   0  0
    2.6137   -7.4838    0.0000 C   0  0
    2.6080   -5.9838    0.0000 C   0  0
    3.9097   -6.7287    0.0000 C   0  0
    3.9164   -8.2289    0.0000 C   0  0
    5.2185   -8.9736    0.0000 N   0  0
   -5.1828   -6.0040    0.0000 C   0  0
   -6.4844   -5.2585    0.0000 C   0  0
   -6.4896   -3.7585    0.0000 C   0  0
   -7.7912   -3.0131    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 20 22  1  0
 22 23  1  0
 22 24  1  0
 22 25  1  0
 25 26  3  0
 12 27  2  0
 27 28  1  0
 28 29  2  0
 29 10  1  0
 29 30  1  0
  8 31  1  0
 31 32  2  0
 32  5  1  0
 32 33  1  0
 33  2  1  0
 33 34  2  0
M  END
> <name>
UTKinase_V5

> <id>
28597

> <plate>
Kinase v5-2

> <well>
H07

> <supplier_cmpd_name>
AZ628

> <ctcr_id>
3889

> <supplier_cmpd_id>
S2746

> <smiles>
CN1C=Nc2ccc(Nc3cc(NC(=O)c4cccc(c4)C(C)(C)C#N)ccc3C)cc2C1=O

> <pd_targets>
{BRAF,YES1,RAF1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TK protein kinase group","TKL protein kinase RAF family","Tyrosine protein kinase Src family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","RAF family","Non-receptor tyrosine kinases (nRTKs)","Src family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Signaling by Receptor Tyrosine Kinases","Infectious disease","MAPK family signaling cascades","Signaling by NTRKs","Leishmania infection","MAPK1/MAPK3 signaling","Signa
ling by NTRK1 (TRKA)","Leishmania parasite growth and survival","RAF/MAP kinase cascade","Signalling to ERKs","Anti-inflammatory response favouring Leishmania parasite infection","Negative regulation 
of MAPK pathway","Prolonged ERK activation events","FCGR3A-mediated IL10 synthesis","Negative feedback regulation of MAPK pathway","ARMS-mediated activation"}

> <broad_targets>
{BRAF,RAF1}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{878739-06-1,878739061,AZ-628,AZ628,"AZ 628",UNII-560S6B5D79,UNII560S6B5D79,AZD628,CHEMBL2144069,560S6B5D79,C27H25N5O2,B1E,cc-82,cc82,MLS006010314,GTPL8475,SCHEMBL4209241,CHEBI:91354,DTXSID70236677,EX
-A302,EXA302,QCR-186,QCR186,HMS3265I11,HMS3265I12,HMS3265J11,HMS3265J12,HMS3656F21,HMS3743G19,S2746}

> <pdid>
PD010687

> <targets>
{Raf}

> <classes>
{MAPK}

> <pubchem_cids>
{11676786}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    9.0685    5.2795    0.0000 C   0  0
    9.0758    3.7795    0.0000 N   0  0
    7.7802    3.0220    0.0000 C   0  0
    6.4773    3.7652    0.0000 O   0  0
    7.7876    1.5211    0.0000 C   0  0
    6.4920    0.7636    0.0000 N   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2982    3.7531    0.0000 N   0  0
    1.2960    5.2539    0.0000 C   0  0
   -0.0056    5.9995    0.0000 C   0  0
   -0.0108    7.4995    0.0000 C   0  0
    1.2856    8.2540    0.0000 C   0  0
    2.5873    7.5085    0.0000 C   0  0
    3.8837    8.2630    0.0000 Cl  0  0
    2.5924    6.0085    0.0000 C   0  0
    3.8941    5.2631    0.0000 F   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11  6  1  0
  9 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 24 18  1  0
 24 25  1  0
 16 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 15  1  0
 29 30  1  0
 30 31  2  0
 31 13  1  0
 31 32  1  0
 32 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28598

> <plate>
Kinase v5-2

> <well>
H09

> <supplier_cmpd_name>
AZD8931

> <ctcr_id>
1497

> <supplier_cmpd_id>
S2192

> <smiles>
CNC(=O)CN1CCC(CC1)Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC

> <pd_targets>
{ERBB3,EGFR,ERBB2,ERBB4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Neuronal System","Intracellular signaling by second messengers","Signaling by GPCR","Nervous system development","Transmission across Chemical Synapses"
,"PIP3 activates AKT signaling","GPCR downstream signalling","Axon guidance","Neurotransmitter receptors and postsynaptic signal transmission","Negative regulation of the PI3K/AKT network","G alpha (q
) signalling events","Semaphorin interactions","Activation of NMDA receptors and postsynaptic events",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Gastrin-CREB signalling pathway via PKC and MAPK
","Sema4D in semaphorin signaling","Post NMDA receptor activation events","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone collapse","Long-term potentiation"}

> <broad_targets>
{EGFR,ERBB2,ERBB3}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{Sapitinib,AZD8931,848942-61-0,848942610,AZD-8931,"AZD8931 (Sapitinib)",Sapitinib(AZD8931),UNII-3499328002,UNII3499328002,CHEMBL2408045,"Sapitinib (AZD-8931)","Sapitinib (AZD8931)","Sapitinib (INN)","
Sapitinib (WHO-DD)","Sapitinib (WHODD)",sapitinibum,"AZD 8931",AZD-8931(Sapitinib),AZD8931(Sapitinib),cc-427,cc427,MLS006011283,SCHEMBL202358,T6092,S2192}

> <pdid>
PD010834

> <targets>
{EGFR,HER2}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{11488320}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    7.7996   -1.4883    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 N   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.5972    1.5031    0.0000 C   0  0
    3.8976    0.7554    0.0000 O   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8915    3.7585    0.0000 C   0  0
    5.1932    3.0131    0.0000 F   0  0
    3.8863    5.2585    0.0000 C   0  0
    2.5847    6.0040    0.0000 C   0  0
    2.5795    7.5040    0.0000 C   0  0
    1.2883    5.2495    0.0000 C   0  0
    1.2934    3.7495    0.0000 C   0  0
   -0.0030    2.9951    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14  6  1  0
 14 10  2  0
  7 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 17  1  0
 24 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28599

> <plate>
Kinase v5-2

> <well>
H11

> <supplier_cmpd_name>
BMS-265246

> <ctcr_id>
5763

> <supplier_cmpd_id>
S2014

> <smiles>
CCCCOc1c(cnc2[nH]ncc12)C(=O)c3c(F)cc(C)cc3F

> <pd_targets>
{CCNE1,CCNE2,CDK2,CCND1,CDK4,CDK1,CCNB1,CCNB2,CCNB3,CCND2,CCND3,CCNA2,CCNT1,CDK9,CDK5,CDK5R1,CCNH,CDK7,MNAT1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK7 subfami
ly"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK1 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","Regulation of mitotic cell cycle","Transcriptional Regulation by TP53","APC/C
-mediated degradation of cell cycle proteins","Regulation of TP53 Activity","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Expression and Degradatio
n","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cd
c20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MS26524,UNII-4GF4A623RF,UNII4GF4A623RF,4GF4A623RF,GTPL8051,CCG-267974,CCG267974,AS-56200,AS56200,S2014,BMS-265246}

> <pdid>
PD003264

> <targets>
{CDK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{5329775}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    6.4760   -2.2250    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.1557   -4.4845    0.0000 C   0  0
    3.8551   -5.2334    0.0000 C   0  0
    3.8250   -6.7319    0.0000 C   0  0
    2.5111   -7.4555    0.0000 C   0  0
    1.2275   -6.6794    0.0000 C   0  0
   -0.0864   -7.4030    0.0000 Cl  0  0
    1.2578   -5.1797    0.0000 C   0  0
    2.5717   -4.4561    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16  8  1  0
 16 12  2  0
  2 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28600

> <plate>
Kinase v5-2

> <well>
H13

> <supplier_cmpd_name>
CCT128930

> <ctcr_id>
6324

> <supplier_cmpd_id>
S2635

> <smiles>
NC1(CCN(CC1)c2ncnc3[nH]ccc23)Cc4ccc(Cl)cc4

> <pd_targets>
{AKT2,RPS6KB1,CYP2C9,CYP2D6,GSK3B,AKT1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 2","AGC protein kinase group","Cytochrome P450 family 2C","Cytochrome P450 family 2D","CMGC protein kinase group","AGC protein
 kinase AKT family","AGC protein kinase RSK family","Cytochrome P450 2C9","Cytochrome P450 2D6","CMGC protein kinase GSK family","AGC protein kinase p70 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Cytochrome P450","AGC: Containing PKA",PKG,"PKC families","CYP2 family: drug metabolising subset","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Akt (Protein kinase 
B","PKB) family","RSK family","Glycogen synthase kinase (GSK) family","p70 subfamily","GSK subfamily"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,Disease,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","MTOR signalling","Biological oxidations","Infectious disease","RNA Polymerase II T
ranscription","Signaling by Insulin receptor","mTORC1-mediated signalling","Phase I - Functionalization of compounds","SARS-CoV Infections","Generic Transcription Pathway","Insulin receptor signalling
 cascade","Cytochrome P450 - arranged by substrate type","SARS-CoV-1 Infection","Transcriptional Regulation by TP53","IRS-mediated signalling",Xenobiotics,"SARS-CoV-1 Genome Replication and Transcript
ion","Regulation of TP53 Activity","PI3K Cascade","CYP2E1 reactions","Replication of the SARS-CoV-1 genome","Regulation of TP53 Expression and Degradation","PKB-mediated events","Regulation of TP53 De
gradation","PDE3B signalling"}

> <broad_targets>
{}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{CCT128930,885499-61-6,885499616,CCT-128930,"4-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-amine","4(4chlorobenzyl)1(7Hpyrrolo(2,3d)pyrimidin4yl)piperidin4amine","CCT 128930",CHEMB
L263664,C18H20ClN5,M05,cc-512,cc512,MLS006010998,SCHEMBL1002126,DTXSID80590818,HMS3656J07,HMS3750O13,BCP02903,BDBM50237622,MFC,S2635}

> <pdid>
PD010906

> <targets>
{Akt}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{17751819}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -2.6078    5.9988    0.0000 N   0  0
   -2.6109    7.4996    0.0000 C   0  0
   -3.9100    8.2496    0.0000 N   0  0
   -3.9100    9.7496    0.0000 C   0  0
   -2.6110   10.4997    0.0000 C   0  0
   -2.6111   12.0004    0.0000 N   0  0
   -3.8232   12.8622    0.0000 C   0  0
   -3.3575   14.2880    0.0000 C   0  0
   -1.8575   14.2857    0.0000 N   0  0
   -1.3962   12.8584    0.0000 C   0  0
   -1.3119    9.7497    0.0000 C   0  0
   -1.3119    8.2497    0.0000 N   0  0
   -0.0123   10.5001    0.0000 C   0  0
    1.2857    9.7482    0.0000 C   0  0
    2.5859   10.4961    0.0000 C   0  0
    2.5882   11.9961    0.0000 C   0  0
    3.8884   12.7441    0.0000 Cl  0  0
    1.2904   12.7482    0.0000 C   0  0
   -0.0099   12.0002    0.0000 C   0  0
   -0.8751   12.5016    0.0000 Cl  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  3
    1.2947   -3.7531    0.0000 O   0  5
   -1.3032   -3.7490    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 13  1  0
 12 18  1  0
 18 19  2  0
 19  9  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 20  1  0
 26 27  1  0
  4 28  2  0
 28 29  1  0
 29 30  2  0
 30  2  1  0
 30 31  1  0
 31 32  1  0
 31 33  2  0
M  CHG  2  31   1  32  -1
M  END
> <name>
UTKinase_V5

> <id>
28601

> <plate>
Kinase v5-2

> <well>
H15

> <supplier_cmpd_name>
CHIR-98014

> <ctcr_id>
5756

> <supplier_cmpd_id>
S2745

> <smiles>
Nc1nc(NCCNc2ncc(n3ccnc3)c(n2)c4ccc(Cl)cc4Cl)ccc1[N+]([O-])=O

> <pd_targets>
{CDK1,GSK3B,GSK3A}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase GSK family","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","Glycogen synthase kinase (GSK) family","CDK1 subfamily","GSK subfamily"}

> <pathway_reactome>
{"Cell Cycle",Disease,Mitotic,"Infectious disease","Regulation of mitotic cell cycle","SARS-CoV Infections","APC/C-mediated degradation of cell cycle proteins","SARS-CoV-1 Infection","Activation of AP
C/C and APC/C:Cdc20 mediated degradation of mitotic proteins","SARS-CoV-1 Genome Replication and Transcription","APC/C:Cdc20 mediated degradation of mitotic proteins","Replication of the SARS-CoV-1 ge
nome","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{GSK3A,GSK3B}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{HIR9801,CHIR-98014,CHIR98014,252935-94-7,252935947,CT-98014,CT98014,CHEMBL3185148,cc-83,cc83,GTPL8016,"Chir98014, 20",SCHEMBL14672557,BDBM92356,AOB6865,DTXSID50694251,CHEBI:167657,BCP01900,EX-A1079,E
XA1079,BDBM50243389,MFCD10565922,s2745,ZINC42856088,AKOS015994559,BCP9000519,CCG-269591,CCG269591,CS-312,CS312,T2608,S2745,"CHIR 98014"}

> <pdid>
PD012780

> <targets>
{GSK-3,GSK3}

> <classes>
{}

> <pubchem_cids>
{53396311}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 45  0  0  0  0            999 V2000
   16.8691   10.2322    0.0000 C   0  0
   15.4464    9.7570    0.0000 N   0  0
   15.1454    8.2867    0.0000 C   0  0
   16.2680    7.2918    0.0000 O   0  0
   13.7219    7.8112    0.0000 C   0  0
   13.4190    6.3421    0.0000 C   0  0
   11.9952    5.8698    0.0000 C   0  0
   11.6892    4.4005    0.0000 O   0  0
   10.2640    3.9300    0.0000 C   0  0
    9.9560    2.4620    0.0000 C   0  0
    8.5307    1.9947    0.0000 C   0  0
    7.4132    2.9954    0.0000 C   0  0
    5.9880    2.5249    0.0000 N   0  0
    5.6819    1.0557    0.0000 C   0  0
    6.8010    0.0568    0.0000 O   0  0
    4.2567    0.5852    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    4.8082   -4.6653    0.0000 C   0  0
    6.2996   -4.8254    0.0000 C   0  0
    3.9242   -5.8772    0.0000 C   0  0
    5.4155   -6.0369    0.0000 C   0  0
    7.7213    4.4634    0.0000 C   0  0
    6.6039    5.4642    0.0000 F   0  0
    9.1466    4.9307    0.0000 C   0  0
   10.8744    6.8668    0.0000 C   0  0
   11.1773    8.3359    0.0000 C   0  0
   12.6010    8.8081    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 17  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 25  1  0
 30 31  2  0
 31 22  1  0
 19 32  1  0
 32 33  1  0
 32 34  1  0
 32 35  1  0
 12 36  1  0
 36 37  1  0
 36 38  2  0
 38  9  1  0
  7 39  2  0
 39 40  1  0
 40 41  2  0
 41  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28602

> <plate>
Kinase v5-2

> <well>
H17

> <supplier_cmpd_name>
DCC-2036 (Rebastinib)

> <ctcr_id>
6197

> <supplier_cmpd_id>
S2634

> <smiles>
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3c4ccc5ncccc5c4)C(C)(C)C)c(F)c2)ccn1

> <pd_targets>
{YES1,ABL1,FLT3,TEK,KDR,LYN,BCR,NTRK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Atypical protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR famil
y","Tyrosine protein kinase Tie family","Tyrosine protein kinase VEGFR family","Atypical protein kinase BCR family","Tyrosine protein kinase Trk family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases",Atypical,"TK: Tyrosine kinase","BCR family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)
","Src family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Type IV RTKs: VEGF (vascular endothelial growth factor) recept
or family","Type VII RTKs: Neurotrophin receptor/Trk family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Infectious disease","Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","Diseases of signal transduction by growth factor receptors and second mes
sengers","Leishmania infection","Signaling by Insulin receptor","MAPK1/MAPK3 signaling","Signaling by VEGF","Signaling by FGFR in disease","Signaling by NTRKs","Leishmania parasite growth and survival
","Parasite infection","Insulin receptor signalling cascade","RAF/MAP kinase cascade","VEGFA-VEGFR2 Pathway","Signaling by FGFR1 in disease","Signaling by NTRK1 (TRKA)","Anti-inflammatory response fav
ouring Leishmania parasite infection","Leishmania phagocytosis","IRS-mediated signalling","VEGFR2 mediated cell proliferation","FGFR1 mutant receptor activation","Signalling to ERKs","FCGR3A-mediated 
IL10 synthesis","FCGR3A-mediated phagocytosis","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Prolonged ERK activation events","ARMS-mediated activation"}

> <broad_targets>
{ABL1,BCR,FGR,FLT3,HCK,LYN,SRC}

> <broad_moa>
{"Bcr-Abl kinase inhibitor","TIE tyrosine kinase inhibitor","VEGFR inhibitor"}

> <synonyms>
{"DCC-2036 (Rebastinib)","DCC2036 (Rebastinib)","DCC 2036",REBASTINIB,DCC-2036,DCC2036,1020172-07-9,1020172079,CHEBI:62166,UNII-75017Q6I97,UNII75017Q6I97,DP-1919,DP1919,75017Q6I97,"Rebastinib (USAN:IN
N)",3qri,3qrj,"Rebastinib (USAN)","DP 1919",Rebastinib/DCC-2036,Rebastinib/DCC2036,"DCC-2036; Rebastinib","DCC2036; Rebastinib",Rebastinib(DCC-2036),Rebastinib(DCC2036),cc-606,cc606,T2640,S2634}

> <pdid>
PD010907

> <targets>
{Bcr-Abl,Apoptosis,FLT3,Src}

> <classes>
{Angiogenesis,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{25066467}

$$$$
UTKinase_V5
  SciTegic11012413002D

 46 51  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -6.5018    3.7420    0.0000 C   0  0
   -6.5068    5.2419    0.0000 O   0  0
   -7.7993    2.9876    0.0000 N   0  0
   -9.1017    3.7333    0.0000 C   0  0
  -10.3996    2.9813    0.0000 C   0  0
  -11.6999    3.7292    0.0000 C   0  0
  -13.0000    2.9793    0.0000 O   0  0
  -14.2999    3.7295    0.0000 C   0  0
  -15.6004    2.9819    0.0000 C   0  0
  -16.8980    3.7343    0.0000 C   0  0
  -16.8953    5.2343    0.0000 C   0  0
  -18.1952    5.9845    0.0000 N   0  0
  -19.4952    5.2346    0.0000 C   0  0
  -19.4954    3.7346    0.0000 O   0  0
  -20.7952    5.9847    0.0000 C   0  0
  -21.5452    7.1505    0.0000 C   0  0
  -20.0452    7.1506    0.0000 C   0  0
  -22.0953    5.2343    0.0000 C   0  0
  -22.0950    3.7343    0.0000 O   0  0
  -23.3955    5.9840    0.0000 N   0  0
  -24.6953    5.2337    0.0000 C   0  0
  -25.9959    5.9812    0.0000 C   0  0
  -27.2935    5.2287    0.0000 C   0  0
  -27.2906    3.7287    0.0000 C   0  0
  -28.5882    2.9761    0.0000 F   0  0
  -25.9901    2.9812    0.0000 C   0  0
  -24.6925    3.7337    0.0000 C   0  0
  -15.5948    5.9819    0.0000 C   0  0
  -15.5921    7.4819    0.0000 F   0  0
  -14.2972    5.2295    0.0000 C   0  0
  -11.7023    5.2292    0.0000 C   0  0
  -10.4045    5.9813    0.0000 C   0  0
   -9.1042    5.2334    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 30 28  1  0
 28 31  1  0
 31 32  2  0
 31 33  1  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 38  1  0
 37 39  1  0
 39 40  2  0
 40 34  1  0
 24 41  1  0
 41 42  1  0
 41 43  2  0
 43 21  1  0
 19 44  2  0
 44 45  1  0
 45 46  2  0
 46 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28603

> <plate>
Kinase v5-2

> <well>
H19

> <supplier_cmpd_name>
Golvatinib (E7050)

> <ctcr_id>
2506

> <supplier_cmpd_id>
S2859

> <smiles>
CN1CCN(CC1)C2CCN(CC2)C(=O)Nc3cc(Oc4ccc(NC(=O)C5(CC5)C(=O)Nc6ccc(F)cc6)c(F)c4)ccn3

> <pd_targets>
{KDR,MET}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type X RTKs: HGF
 (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Signaling by Receptor Tyrosine Kinases","Nervous system development","Signaling by VEGF","Axon guidance","VEGFA-VEGFR2 Pathway","Semaphorin interactions
","VEGFR2 mediated cell proliferation","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{KDR,MET}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{Golvatinib,928037-13-2,928037132,"Golvatinib (E7050)",E-7050,E7050,UNII-516Z3YP58E,UNII516Z3YP58E,516Z3YP58E,"Golvatinib (USAN)","Golvatinib (USAN:INN)",E7050;Golvatinib,GolvatinibE7050),"E 7050",cc-
653,cc653,GTPL7956,SCHEMBL1727298,CHEMBL3039525,DTXSID40239155,EX-,EX,T6517,S2859}

> <pdid>
PD010544

> <targets>
{c-Met,VEGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{16118392}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 26  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
    1.2947   -3.7531    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 N   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6060   -6.0003    0.0000 C   0  0
   -2.6060   -7.5003    0.0000 C   0  0
   -1.3070   -8.2503    0.0000 C   0  0
   -0.0080   -7.5003    0.0000 C   0  0
   -0.0079   -6.0003    0.0000 C   0  0
    1.2918   -8.2508    0.0000 C   0  0
    1.2927   -9.7508    0.0000 F   0  0
    2.5906   -7.5004    0.0000 F   0  0
    2.5911   -9.0002    0.0000 F   0  0
   -3.9058   -8.2507    0.0000 C   0  0
   -5.2053   -7.5015    0.0000 F   0  0
   -3.9054   -9.7507    0.0000 F   0  0
   -5.2045   -9.0013    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 16 18  1  0
 18 19  1  0
 18 20  1  0
 18 21  1  0
 14 22  1  0
 22 23  1  0
 22 24  1  0
 22 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28604

> <plate>
Kinase v5-2

> <well>
H21

> <supplier_cmpd_name>
IMD 0354

> <ctcr_id>
1228

> <supplier_cmpd_id>
S2864

> <smiles>
Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F

> <pd_targets>
{TMPRSS4,RORC,KMT2A,MEN1,FLT3,KDR,IKBKB}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator",Protease,"Nuclear receptor",Reader,Kinase,"Serine protease","Nuclear hormone receptor subfamily 1",Bromodomain,"Protein Kinase","Nuclear hormone r
eceptor subfamily 1 group F","TK protein kinase group","Other protein kinase group","Nuclear hormone receptor subfamily 1 group F member 3","Tyrosine protein kinase PDGFR family","Tyrosine protein kin
ase VEGFR family","Other protein kinase IKK family"}

> <pathway_chembl>
{Receptors,"Nuclear hormone receptors","Catalytic receptors","1F. Retinoic acid-related orphans","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kinases (RTKs)","IK
K family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Immune System","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Generic Transcription Pathwa
y","Signaling by Insulin receptor","Signaling by VEGF","Toll-like Receptor Cascades","Transcriptional regulation by RUNX3","Insulin receptor signalling cascade","VEGFA-VEGFR2 Pathway","Toll Like Recep
tor 4 (TLR4) Cascade","RUNX3 Regulates Immune Response and Cell Migration","IRS-mediated signalling","VEGFR2 mediated cell proliferation","MyD88-independent TLR4 cascade","PI3K Cascade","TRIF(TICAM1)-
mediated TLR4 signaling","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
{IKBKB}

> <broad_moa>
{"IKK inhibitor","NFkB pathway inhibitor"}

> <synonyms>
{IMD-0354,IMD0354,978-62-1,978621,"IMD 0354","IKK-2 Inhibitor V","IKK2 Inhibitor V","N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide","N(3,5bis(trifluoromethyl)phenyl)5chloro2hydroxyben
zamide",TCMDC-125465,TCMDC125465,UNII-76145IS906,UNII76145IS906,CHEMBL536151,"N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide","N(3,5Bistrifluoromethylphenyl)5chloro2hydroxybenzamide",MF
CD00218820,761,T6141,2611,"EMD 401482",S2864,401482}

> <pdid>
PD010541

> <targets>
{IKK,"IKK-2 Inhibitor V"}

> <classes>
{}

> <pubchem_cids>
{5081913}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
   -2.1571   -9.0669    0.0000 O   0  0
   -3.5959   -8.6430    0.0000 C   0  0
   -4.6824   -9.6772    0.0000 C   0  0
   -6.1213   -9.2533    0.0000 C   0  0
   -6.4737   -7.7953    0.0000 C   0  0
   -5.3872   -6.7611    0.0000 C   0  0
   -3.9482   -7.1849    0.0000 C   0  0
   -2.8628   -6.1485    0.0000 C   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 C   0  0
   -3.2175   -4.6910    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 C   0  0
   -3.8978    2.2504    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  2  3
 22 23  1  0
 22 24  1  0
 24 14  1  0
 24 17  2  0
 21 25  1  0
 25 26  3  0
M  END
> <name>
UTKinase_V5

> <id>
28605

> <plate>
Kinase v5-2

> <well>
J03

> <supplier_cmpd_name>
A-769662

> <ctcr_id>
6722

> <supplier_cmpd_id>
S2697

> <smiles>
Oc1ccccc1c2ccc(cc2)c3csc4NC(=O)C(=C(O)c34)C#N

> <pd_targets>
{PRKAA1,PRKAA2,PRKAB1,PRKAB2,PRKAG1,PRKAG2,PRKAG3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase CAMK1 family","CAMK protein kinase AMPK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","CAMK-like (CAMKL) family","AMPK subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by TP53","Regulation of TP53 Activity","Regulation of TP53 Activity thr
ough Phosphorylation"}

> <broad_targets>
{}

> <broad_moa>
{"AMPK activator"}

> <synonyms>
{76966,844499-71-4,844499714,A-769662,A769662,"A 769662",UNII-P68477CD2C,UNIIP68477CD2C,CHEMBL512504,C20H12N2O3S,P68477CD2C,4cff,PubChem16661,cc-24,cc24,MLS006011221,SCHEMBL2669403,SCHEMBL15008545,CHE
BI:91429,GTPL10069,AOB1779,DTXSID30233425,EX-A380,EXA380,BCPP000450,HMS3295O03,HMS3413J08,T2468,S2697}

> <pdid>
PD010881

> <targets>
{AMPK,"AMPK agonist"}

> <classes>
{}

> <pubchem_cids>
{54708532}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 33  0  0  0  0            999 V2000
    2.5840   -8.2829    0.0000 O   0  0
    2.8570   -6.8080    0.0000 C   0  0
    4.2107   -6.1619    0.0000 N   0  0
    4.0146   -4.6747    0.0000 C   0  0
    5.0960   -3.6352    0.0000 O   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.8242   -5.7201    0.0000 C   0  0
    0.3349   -5.9052    0.0000 C   0  0
   -0.5693   -4.7231    0.0000 C   0  0
   -1.9763   -5.2432    0.0000 N   0  0
   -1.9162   -6.7412    0.0000 C   0  0
   -2.9899   -7.7886    0.0000 C   0  0
   -2.6197   -9.2422    0.0000 C   0  0
   -1.1758   -9.6484    0.0000 C   0  0
   -0.1020   -8.6010    0.0000 C   0  0
   -0.4722   -7.1474    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5085   -1.7165    0.0000 C   0  0
   -2.3518   -3.2083    0.0000 C   0  0
   -0.9815   -3.8184    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  8  1  0
 16 11  1  0
  6 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 17  1  0
 27 28  2  0
 28 19  1  0
 28 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28606

> <plate>
Kinase v5-2

> <well>
J05

> <supplier_cmpd_name>
ARQ 197 (Tivantinib)

> <ctcr_id>
5618

> <supplier_cmpd_id>
S2753

> <smiles>
O=C1NC(=O)C(C1c2c[nH]c3ccccc23)c4cn5CCCc6cccc4c56

> <pd_targets>
{MET}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Semaphorin interactions","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{MET}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{1239986-50-5,1239986505,"Tivantinib (ARQ 197)",905853-99-8,905853998,SCHEMBL1395795,CS-M1129,CSM1129,3211AH,MFCD18917093,AKOS015994983,VA12017,NCGC00387836-01,NCGC0038783601,AK-77515,AK77515,AS-74295
,AS74295,S2753,"ARQ 197 (Tivantinib)"}

> <pdid>
PD003457

> <targets>
{c-Met}

> <classes>
{}

> <pubchem_cids>
{57355660}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    2.5814   -7.4998    0.0000 C   0  0
    2.5868   -5.9998    0.0000 N   0  0
    3.8888   -5.2533    0.0000 C   0  0
    5.1854   -6.0076    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968   -1.5004    0.0000 N   0  0
   -5.1945   -3.0005    0.0000 C   0  0
   -6.4924   -3.7525    0.0000 C   0  0
   -7.7926   -3.0046    0.0000 O   0  0
   -7.7950   -1.5046    0.0000 C   0  0
   -6.4971   -0.7525    0.0000 C   0  0
   -6.4996    0.7475    0.0000 C   0  0
   -2.5981    3.0007    0.0000 N   0  0
   -3.8983    3.7488    0.0000 C   0  0
   -3.9007    5.2488    0.0000 C   0  0
   -2.6029    6.0009    0.0000 O   0  0
   -1.3026    5.2529    0.0000 C   0  0
   -1.3003    3.7529    0.0000 C   0  0
    0.0000    3.0050    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 14  1  0
 19 20  2  0
 20 11  1  0
 17 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 26 27  1  0
 15 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 28  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28607

> <plate>
Kinase v5-2

> <well>
J07

> <supplier_cmpd_name>
AZD2014

> <ctcr_id>
4665

> <supplier_cmpd_id>
S2783

> <smiles>
CNC(=O)c1cccc(c1)c2ccc3c(nc(nc3n2)N4CCOCC4C)N5CCOCC5C

> <pd_targets>
{MTOR,PIK3CG,PIK3CB,KCNH2,PIK3CD,PIK3CA,PIK3C3,PIK3R1,MLST8,RPTOR}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,Transferase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","Atypical protein kinase group","Voltage-gated potassium channel","Atypical protein kinase PI
KK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels","Kinases (EC 2.7.x.x)","Voltage-gated ion channels",Atypical,"Lipid modifying kinases","Potassium channels","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phos
phatidylinositol-4,"5-bisphosphate 3-kinase family","Voltage-gated potassium channels","Phosphatidylinositol 3-kinase family","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Metabolism,"Signal Transduction","Muscle contraction","Immune System",Disease,"RNA Polymerase II Transcription","Metabolism of lipids","Signaling by Receptor Tyrosin
e Kinases","Cardiac conduction","Cytokine Signaling in Immune system","Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","Phospholipid m
etabolism","Signaling by Insulin receptor","Phase 3 - rapid repolarisation","Signaling by Interleukins","Signaling by FGFR in disease","Transcriptional Regulation by TP53","PI Metabolism","Insulin rec
eptor signalling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Signaling by FGFR1 in disease","Regulation of TP53 Activity","Synthesis of PIPs at the plasma membrane","IRS-mediated sign
alling","Interleukin receptor SHC signaling","FGFR1 mutant receptor activation","Regulation of TP53 Expression and Degradation","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation
 of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{SCHEMBL1214881,HMS3656H08,HMS3674E19,AKOS026750285,AK163424,DA-35312,DA35312,FT-0773699,FT0773699,S2783,AZD2014}

> <pdid>
PD003275

> <targets>
{mTOR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{44200550}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    9.9949    2.8884    0.0000 C   0  0
    9.3803    1.5201    0.0000 C   0  0
    7.8873    1.3671    0.0000 S   0  0
    7.0092    2.5832    0.0000 O   0  0
    8.5012    2.7357    0.0000 O   0  0
    7.2749    0.0036    0.0000 N   0  0
    5.8727   -0.5294    0.0000 C   0  0
    6.4440   -1.8462    0.0000 C   0  0
    7.3224   -3.0632    0.0000 C   0  0
    8.8156   -2.9119    0.0000 C   0  0
   10.3080   -2.7606    0.0000 N   0  0
    7.8079   -1.3985    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  2  0
  3  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  3  0
  8 12  1  0
 12  6  1  0
  8 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 13  1  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 18  1  0
 26 22  2  0
M  END
> <name>
UTKinase_V5

> <id>
28608

> <plate>
Kinase v5-2

> <well>
J09

> <supplier_cmpd_name>
Baricitinib (LY3009104)

> <ctcr_id>
6687

> <supplier_cmpd_id>
S2851

> <smiles>
CCS(=O)(=O)N1CC(CC#N)(C1)n2cc(cn2)c3ncnc4[nH]ccc34

> <pd_targets>
{JAK2,TYK2,JAK3,AAK1,JAK1,BMP2K,GAK,PTK2B}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","Tyrosine protein kinase JakA family","Other protein kinase NAK family","Tyrosine protein kinase Fak family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Non-receptor tyrosine kinases (nRTKs)","NAK family","Numb-associated kinase (NAK) family","Janus kina
se (JakA) family","Fak family"}

> <pathway_reactome>
{"Cell Cycle","Immune System","Vesicle-mediated transport",Mitotic,"Cytokine Signaling in Immune system","Membrane Trafficking","Mitotic G1 phase and G1/S transition","Interferon Signaling","Signaling
 by Interleukins","Clathrin-mediated endocytosis","trans-Golgi Network Vesicle Budding","G1 Phase","Interferon alpha/beta signaling","Interleukin-2 family signaling","Cargo recognition for clathrin-me
diated endocytosis","Antiviral mechanism by IFN-stimulated genes","Golgi Associated Vesicle Biogenesis","Cyclin D associated events in G1","Regulation of IFNA signaling","Interleukin-15 signaling","IS
G15 antiviral mechanism","Interleukin-2 signaling"}

> <broad_targets>
{JAK1,JAK2}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{Baricitinib,1187594-09-7,1187594097,INCB028050,olumiant,LY3009104,"INCB 028050",INCB-028050,UNII-ISP4442I3Y,UNIIISP4442I3Y,"Baricitinib (LY3009104, INCB028050)",LY-3009104,ISP4442I3Y,"LY 3009104","11
87594-09-7 (free base)","1187594097 (free base)","LY3009104 (phosphate);INCB02805",T2485,S2851,"Baricitinib (LY3009104)"}

> <pdid>
PD010550

> <targets>
{JAK}

> <classes>
{}

> <pubchem_cids>
{44205240}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  1  0            999 V2000
    4.0613   -7.0156    0.0000 C   0  0
    4.8090   -5.7153    0.0000 C   0  0  1  0  0  0
    6.3090   -5.7131    0.0000 O   0  0
    4.0559   -4.4171    0.0000 C   0  0
    2.5551   -4.4192    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 O   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -3.8939    0.7546    0.0000 C   0  0
   -5.1904    1.5090    0.0000 C   0  0
   -6.4920    0.7635    0.0000 C   0  0
   -7.9161    1.2320    0.0000 N   0  0
   -8.8020    0.0215    0.0000 C   0  0
  -10.3020    0.0267    0.0000 C   0  0
   -7.9245   -1.1951    0.0000 C   0  0
   -6.4971   -0.7365    0.0000 C   0  0
   -5.2007   -1.4909    0.0000 C   0  0
   -5.2059   -2.9909    0.0000 F   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6923   -4.0811    0.0000 C   0  0
  2  1  1  6
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  2  0
 21 22  1  0
 22 17  1  0
 22 23  2  0
 23 14  1  0
 23 24  1  0
 12 25  1  0
 25  8  1  0
 25 26  2  0
 26  6  1  0
 26 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28609

> <plate>
Kinase v5-2

> <well>
J11

> <supplier_cmpd_name>
Brivanib (BMS-540215)

> <ctcr_id>
694

> <supplier_cmpd_id>
S1084

> <smiles>
C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C

> <pd_targets>
{BLK,TIE1,KDR,FGFR1,PDGFRA,STK33,ABL1,FLT1,EPHA6,KIT,RIPK2,EPHB6,CYP3A4,RET,EGFR,KCNH2,MAP3K19,MAP4K4,SRC,STK10,DDR1,SLK,TEK,EPHA7,STK32B,TNIK,FLT4,STK35,LCK,FGFR3,ABL2,HCK,MINK1,MAP2K5,MAP4K5,FGFR4,F
GFR2,PDGFRB,CSF1R}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Ion channel",Kinase,"Cytochrome P450","Voltage-gated ion channel","Protein Kinase","Cytochrome P450 family 3","Potassium channels","TK protein kinase group","CAMK prote
in kinase group","TKL protein kinase group","Cytochrome P450 family 3A","Voltage-gated potassium channel","STE protein kinase group","AGC protein kinase group","Other protein kinase group","Tyrosine p
rotein kinase Src family","Tyrosine protein kinase Tie family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family","CAMK protein kinase 
unique family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Eph family","TKL protein kinase RIPK family","Cytochrome P450 3A4","Tyrosine protein kinase Ret family","Tyrosine protein k
inase EGFR family","STE protein kinase STE11 family","STE protein kinase STE20 family","Tyrosine protein kinase DDR family","AGC protein kinase YANK family","Other protein kinase NKF4 family","STE pro
tein kinase STE7 family","STE protein kinase MSN subfamily","STE protein kinase SLK subfamily","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","Voltage-gated ion channels","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","C
YP3 family","Potassium channels","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","TK: Tyrosine kinase","CAMK-unique family","TKL: Tyrosine
 kinase-like","Voltage-gated potassium channels","STE20 family","YANK family","Other protein kinases","STE7 family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Receptor
 interacting protein kinase (RIPK) family","STE20 subfamily","MSN subfamily","SLK subfamily","NKF4 family","KHS subfamily","Src family","Type XII RTKs: TIE family of angiopoietin receptors","Type IV R
TKs: VEGF (vascular endothelial growth factor) receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Abl family","Type 
XIII RTKs: Ephrin receptor family","Type XIV RTKs: RET","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XVI RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction",Disease,"Developmental Biology","Immune System",Metabolism,"Muscle contraction","Cellular responses to external stimuli","Extracellular matrix 
organization","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Infectious disease","Nervou
s system development","Innate Immune System","Metabolism of lipids","Signaling by GPCR","Cardiac conduction","Cellular responses to stress","Non-integrin membrane-ECM interactions","MAPK family signal
ing cascades","Intracellular signaling by second messengers","Generic Transcription Pathway","Signaling by VEGF","Signaling by FGFR in disease","Signaling by PDGFR in disease","Leishmania infection","
Axon guidance","Signaling by KIT in disease","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving mediators (SPMs)","GPCR downstream signalling","Phase 3 - rapid repolarisation","Ce
llular Senescence","Signaling by NTRKs","Neutrophil degranulation","MAPK1/MAPK3 signaling","HIV Infection","Signaling by FGFR","PIP3 activates AKT signaling","Transcriptional regulation by RUNX1","VEG
FA-VEGFR2 Pathway","Signaling by FGFR1 in disease","Drug resistance of PDGFR mutants","Parasite infection","VEGF ligand-receptor interactions","EPH-Ephrin signaling","Drug resistance of KIT mutants","
Toll Like Receptor 5 (TLR5) Cascade","Biosynthesis of DHA-derived SPMs","RET signaling","G alpha (q) signalling events","Oxidative Stress Induced Senescence","Signaling by NTRK1 (TRKA)","RAF/MAP kinas
e cascade","Host Interactions of HIV factors","Signaling by FGFR3 in disease","Signaling by ROBO receptors","Signaling by FGFR4","Signaling by FGFR2 in disease","Negative regulation of the PI3K/AKT ne
twork","Transcriptional Regulation by VENTX","RUNX1 regulates transcription of genes involved in BCR signaling","VEGFR2 mediated cell proliferation","FGFR1 mutant receptor activation","Imatinib-resist
ant PDGFR mutants","Leishmania phagocytosis","VEGF binds to VEGFR leading to receptor dimerization","EPHA-mediated growth cone collapse","Dasatinib-resistant KIT mutants","MyD88 cascade initiated on p
lasma membrane","EPHB-mediated forward signaling","Biosynthesis of maresins","Gastrin-CREB signalling pathway via PKC and MAPK","Signalling to ERKs","The role of Nef in HIV-1 replication and disease p
athogenesis","Signaling by FGFR3 point mutants in cancer","Role of ABL in ROBO-SLIT signaling","Signalling to ERK5","Downstream signaling of activated FGFR4","FGFR2 mutant receptor activation",PI5P,"P
P2A and IER3 Regulate PI3K/AKT Signaling","Signaling by activated point mutants of FGFR1","FCGR3A-mediated phagocytosis","MAP kinase activation","Biosynthesis of maresin-like SPMs","EGFR Transactivati
on by Gastrin","Signalling to RAS","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","FGFR3 mutant receptor activation","Nef and signal transduction","FR
S-mediated FGFR4 signaling","Activated point mutants of FGFR2","activated TAK1 mediates p38 MAPK activation","p38MAPK events","Nef Mediated CD4 Down-regulation","Signaling by activated point mutants o
f FGFR3"}

> <broad_targets>
{CYP3A4,FGFR1,FLT1,KCNH2,KDR}

> <broad_moa>
{"FGFR inhibitor","VEGFR inhibitor"}

> <synonyms>
{Brivanib,649735-46-6,649735466,BMS-540215,BMS540215,"Brivanib (BMS-540215)","Brivanib (BMS540215)","BMS 540215",UNII-DDU33B674I,UNIIDDU33B674I,"Brivanib (USAN)",CHEMBL377300,DDU33B674I,cc-87,cc87,"Br
ivanib,BMS-540215","Brivanib,BMS540215","Brivanib, BMS 540215",MLS006011288,"Brivanib - BMS-540215","Brivanib  BMS540215",S1084,brivanib}

> <pdid>
PD003474

> <targets>
{VEGFR,FGFR,EGFR}

> <classes>
{}

> <pubchem_cids>
{11234052}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 41  0  0  0  0            999 V2000
    6.4434  -12.5363    0.0000 C   0  0
    5.7954  -11.1835    0.0000 N   0  0
    6.6430   -9.9459    0.0000 C   0  0
    5.9950   -8.5931    0.0000 C   0  0
    4.4994   -8.4778    0.0000 N   0  0
    3.6519   -9.7154    0.0000 C   0  0
    4.2999  -11.0683    0.0000 C   0  0
    3.8490   -7.1253    0.0000 C   0  0
    4.6946   -5.8864    0.0000 C   0  0
    4.0445   -4.5346    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.7031   -5.6606    0.0000 C   0  0
    2.3532   -7.0124    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Br  0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5987   -1.5004    0.0000 N   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 N   0  0
   -6.4915   -3.7597    0.0000 C   0  0
   -6.4870   -5.2605    0.0000 C   0  0
   -7.6961   -6.1265    0.0000 C   0  0
   -7.2254   -7.5507    0.0000 C   0  0
   -8.1009   -8.7687    0.0000 C   0  0
   -5.7254   -7.5431    0.0000 O   0  0
   -5.2691   -6.1142    0.0000 N   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 29 31  1  0
 31 32  1  0
 32 27  2  0
 25 33  1  0
 33 34  1  0
 34 22  1  0
 21 35  2  0
 35 16  1  0
 35 36  1  0
 36 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28610

> <plate>
Kinase v5-2

> <well>
J13

> <supplier_cmpd_name>
CCT137690

> <ctcr_id>
4339

> <supplier_cmpd_id>
S2744

> <smiles>
CN1CCN(CC1)c2ccc(cc2)c3nc4ncc(Br)c(N5CCN(Cc6cc(C)on6)CC5)c4[nH]3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{AURKA,AURKB,AURKC}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{1095382-05-0,1095382050,CCT137690,"CCT 137690",CCT-137690,CHEMBL1236904,cc-66,cc66,C26H31BrN8O,MLS006010283,SCHEMBL4755249,AOB2477,DTXSID30648898,HMS3656D21,BCP02554,EX-A2038,EXA2038,BDBM50335609,s27
44,ZINC58661275,AKOS024458076,AKOS026750563,BCP9000498,CCG-270006,CCG270006,CS-0706,CS0706,T2611,S2744}

> <pdid>

> <targets>
{Aurora Kinase,Apoptosis}

> <classes>
{Cell Cycle,Apoptosis,Cell Cycle/DNA Damage,Epigenetics}

> <pubchem_cids>
{25154041}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  0  0            999 V2000
   13.2944   -1.5781    0.0000 C   0  0
   11.8261   -1.8848    0.0000 O   0  0
   10.8251   -0.7666    0.0000 C   0  0
    9.3560   -1.0736    0.0000 C   0  0
    8.3549    0.0446    0.0000 O   0  0
    6.8858   -0.2623    0.0000 C   0  0
    5.8837    0.8539    0.0000 C   0  0
    4.4160    0.5441    0.0000 C   0  0
    3.9504   -0.8818    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    2.7345   -2.9814    0.0000 C   0  0
    4.2013   -3.2954    0.0000 N   0  0
    4.9525   -1.9980    0.0000 C   0  0
    6.4202   -1.6882    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0008    0.0000 N   0  0
   -3.8959   -3.7529    0.0000 C   0  0
   -3.8935   -5.2529    0.0000 C   0  0
   -2.5933   -6.0009    0.0000 C   0  0
   -2.5909   -7.5009    0.0000 N   0  0
   -1.2954   -5.2488    0.0000 C   0  0
   -1.2978   -3.7488    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  9  1  0
 13 14  2  0
 14  6  1  0
 10 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 26 28  1  0
 28 29  1  0
 29 23  1  0
 22 30  1  0
 30 18  1  0
 30 31  2  0
 31 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28611

> <plate>
Kinase v5-2

> <well>
J15

> <supplier_cmpd_name>
CP 673451

> <ctcr_id>
3726

> <supplier_cmpd_id>
S1536

> <smiles>
COCCOc1ccc2n(cnc2c1)c3ccc4cccc(N5CCC(N)CC5)c4n3

> <pd_targets>
{KIT,PDGFRA,PDGFRB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Diseases of signal transduction by growth factor receptors and second messengers","Intracellular signaling by second messengers","Signaling by KIT in disease","Signalin
g by PDGFR in disease","PIP3 activates AKT signaling","Drug resistance of KIT mutants","Drug resistance of PDGFR mutants","Negative regulation of the PI3K/AKT network","Dasatinib-resistant KIT mutants
","Imatinib-resistant PDGFR mutants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling"}

> <broad_targets>
{KIT,PDGFRA,PDGFRB}

> <broad_moa>
{"PDGFR tyrosine kinase receptor inhibitor"}

> <synonyms>
{CP-673451,CP673451,343787-29-1,343787291,"CP 673451",UNII-0AM0WWD90A,UNII0AM0WWD90A,"CP-673,451","CP673,451",0AM0WWD90A,1-(2-(5-(2-methoxyethoxy)benzimidazol-1-yl)quinolin-8-yl)piperidin-4-amine,1(2(
5(2methoxyethoxy)benzimidazol1yl)quinolin8yl)piperidin4amine,34U,cc-529,cc529,MLS006010955,SCHEMBL859537,GTPL8069,CHEMBL4303508,DTXSID20187948,EX-A284,EXA284,C,T6091,S1536}

> <pdid>
PD003232

> <targets>
{Others,PDGFR}

> <classes>
{Protein Tyrosine Kinase,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{10158940}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
    7.7996   -1.4883    0.0000 C   0  0
    6.4990   -0.7409    0.0000 O   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -6.4842    5.2598    0.0000 C   0  0
   -6.4790    6.7598    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6071   -5.9984    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 18 20  1  0
 20 21  3  0
 12 22  2  0
 22  8  1  0
 22 23  1  0
 23 24  2  0
 24  6  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28612

> <plate>
Kinase v5-2

> <well>
J17

> <supplier_cmpd_name>
Desmethyl Erlotinib (CP-473420)

> <ctcr_id>
1361

> <supplier_cmpd_id>
S2826

> <smiles>
COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCO

> <pd_targets>
{EGFR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by GPCR","GPCR downstream signalling","G alpha (q) signalling events","Gastrin-CREB signalling pathway via PKC and MAPK","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{183321860,"183321 86 0","Desmethyl Erlotinib","OSI-420, Free Base (Desmethyl Erlotinib)","OSI420, Free Base (Desmethyl Erlotinib)","OSI 420, Free Base (Desmethyl Erlotinib)","CP 373420",OSI420,"OSI 4
20",2-(4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxyethanol,2(4(3ethynylanilino)7(2methoxyethoxy)quinazolin6yl)oxyethanol,"2 (4 (3 ethynylanilino) 7 (2 methoxyethoxy)quinazolin 6 yl)oxye
thanol",2-(4-(3-ethynylphenylamino)-7-(2-methoxyethoxy)quinazolin-6-yloxy)ethanol,2(4(3ethynylphenylamino)7(2methoxyethoxy)quinazolin6yloxy)ethanol,"2 (4 (3 ethynylphenylamino) 7 (2 methoxyethoxy)quin
azolin 6 yloxy)ethanol",S2826,"Desmethyl Erlotinib (CP-473420)","Desmethyl Erlotinib (CP-473420, OSI-774)"}

> <pdid>
PD016649

> <targets>
{EGFR}

> <classes>
{}

> <pubchem_cids>
{10317566}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  0  0            999 V2000
    6.3028   -4.8211    0.0000 C   0  0
    4.8111   -4.6641    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    2.7343   -2.9815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5536   -4.4230    0.0000 C   0  0
   -4.0444   -4.5346    0.0000 C   0  0
   -4.6946   -5.8864    0.0000 C   0  0
   -3.8489   -7.1253    0.0000 C   0  0
   -2.3532   -7.0124    0.0000 C   0  0
   -1.5045   -8.2503    0.0000 C   0  0
   -0.0081   -8.1352    0.0000 N   0  0
    0.8400   -9.3724    0.0000 C   0  0
    0.6396   -6.7823    0.0000 C   0  0
   -1.7031   -5.6606    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    5.5263    4.9023    0.0000 N   0  0
    6.9849    5.2556    0.0000 C   0  0
    8.0193    4.1692    0.0000 O   0  0
    7.4092    6.6952    0.0000 N   0  0
    8.8671    7.0482    0.0000 C   0  0
    6.3749    7.7815    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14  6  1  0
 14 10  2  0
 12 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 21 23  1  0
 19 24  2  0
 24 15  1  0
  5 25  1  0
 25 26  2  0
 26  3  1  0
 25 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  1  0
 32 33  2  0
 32 34  1  0
 34 35  1  0
 34 36  1  0
 30 37  1  0
 37 38  2  0
 38 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28613

> <plate>
Kinase v5-2

> <well>
J19

> <supplier_cmpd_name>
GSK1070916

> <ctcr_id>
2447

> <supplier_cmpd_id>
S2740

> <smiles>
CCn1cc(c2ccnc3[nH]c(cc23)c4cccc(CN(C)C)c4)c(n1)c5ccc(NC(=O)N(C)C)cc5

> <pd_targets>
{AURKB,TPX2,FGFR1,AURKA,AURKC,SIK1,CYP2D6,CYP3A4,INCENP,FLT4,FLT1,CYP2C9,CYP2C19,TEK}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 2","Cytochrome P450 family 3","Other protein kinase group","TK protein kinase group","CAMK protein kina
se group","Cytochrome P450 family 2D","Cytochrome P450 family 3A","Cytochrome P450 family 2C","Other protein kinase AUR family","Tyrosine protein kinase FGFR family","CAMK protein kinase CAMK1 family"
,"Cytochrome P450 2D6","Cytochrome P450 3A4","Tyrosine protein kinase VEGFR family","Cytochrome P450 2C9","Cytochrome P450 2C19","Tyrosine protein kinase Tie family","CAMK protein kinase QIK subfamily
"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Cytochrome P450","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CYP2 family: drug metabolising subset","CYP3 
family","Other protein kinases","TK: Tyrosine kinase","CAMK-like (CAMKL) family","Aurora kinase (Aur) family","Receptor tyrosine kinases (RTKs)","QIK subfamily","Type V RTKs: FGF (fibroblast growth fa
ctor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Disease,"Circadian Clock",Metabolism,"Signal Transduction",Mitotic,"RNA Polymerase II Transcription","Diseases of signal transduction by growth factor r
eceptors and second messengers","Biological oxidations","Metabolism of lipids","Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","M Phase","Generic Transcription Pathway","Sign
aling by FGFR in disease","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","Signaling by VEGF","MAPK1/MAPK3 signaling","Mitotic Metaphase and Anap
hase","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","Cytochrome P450 - arranged by substrate type","Biosynthesis of DHA-derived SPMs","VEGF ligand-receptor interactions","RAF/MA
P kinase cascade","Mitotic Anaphase","Regulation of TP53 Activity","FGFR1 mutant receptor activation",Xenobiotics,"Biosynthesis of maresins","VEGF binds to VEGFR leading to receptor dimerization","Sep
aration of Sister Chromatids","Regulation of TP53 Activity through Phosphorylation","Signaling by activated point mutants of FGFR1","CYP2E1 reactions","Biosynthesis of maresin-like SPMs"}

> <broad_targets>
{AURKA,AURKB,AURKC,CYP2D6,CYP3A4}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{"GSK 1070916A",BDBM50315769,GSK1070916,942918-07-2,942918072,GSK-1070916,GSK-1070916A,GSK1070916A,"GSK 1070916",UNII-8VLB51V7HO,UNII8VLB51V7HO,8VLB51V7HO,CHEMBL1090479,"compound 17k (PMID 20420387)",
cc-423,cc423,GTPL8358,SCHEMBL4305006,CHEBI:91362,DTXSID70241403,EX-A021,EXA021,HMS3265K13,HMS3265K14,S2740}

> <pdid>
PD012206

> <targets>
{"Aurora Kinase",Apoptosis}

> <classes>
{Cell Cycle,Apoptosis,Cell Cycle/DNA Damage,Epigenetics}

> <pubchem_cids>
{46885626}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  0  0            999 V2000
   14.6162   -4.2584    0.0000 C   0  0
   13.1478   -4.5647    0.0000 N   0  0
   12.1471   -3.4462    0.0000 C   0  0
   12.6155   -2.0212    0.0000 O   0  0
   10.6779   -3.7527    0.0000 C   0  0
   10.2119   -5.1785    0.0000 C   0  0
    8.7441   -5.4878    0.0000 C   0  0
    7.7422   -4.3714    0.0000 C   0  0
    8.2083   -2.9456    0.0000 C   0  0
    9.6761   -2.6362    0.0000 C   0  0
   10.1421   -1.2105    0.0000 F   0  0
    6.2733   -4.6785    0.0000 C   0  0
    5.8050   -6.1036    0.0000 C   0  0
    4.3368   -6.4106    0.0000 N   0  0
    3.3368   -5.2925    0.0000 C   0  0
    1.8376   -5.2878    0.0000 N   0  0
    1.3788   -3.8597    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8050   -3.8675    0.0000 N   0  0
    5.2733   -3.5605    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 10 11  1  0
  8 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 23  1  0
 28 29  2  0
 29 20  1  0
 18 30  1  0
 30 15  1  0
 30 31  1  0
 31 12  2  0
M  END
> <name>
UTKinase_V5

> <id>
28614

> <plate>
Kinase v5-2

> <well>
J21

> <supplier_cmpd_name>
INCB28060

> <ctcr_id>
1678

> <supplier_cmpd_id>
S2788

> <smiles>
CNC(=O)c1ccc(cc1F)c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2

> <pd_targets>
{MET}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Semaphorin interactions","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{MET}

> <broad_moa>
{"c-Met inhibitor"}

> <synonyms>
{capmatinib,1029712-80-8,1029712808,INCB28060,INC-280,INC280,UNII-TY34L4F9OZ,UNIITY34L4F9OZ,INCB-28060,"Capmatinib (INCB28060)",INC28060,NVP-INC280-NX,NVPINC280NX,NVP-INC280,NVPINC280,TY34L4F9OZ,"INCB
 28060","1029712-80-8 (free base)","1029712808 (free base)",C23H17FN6O,Tabrecta,"benzamide hcl","Capmatinib (USAN)",Capmat,T4260,T1963,S2788,"Capmatinib 2HCl",Capmatinib}

> <pdid>
PD012871

> <targets>
{c-Met,Apoptosis,c-Met/HGFR}

> <classes>
{Protein Tyrosine Kinase,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{25145656}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 42  0  0  0  0            999 V2000
    4.8089   -4.6669    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -3.8916    3.7585    0.0000 C   0  0
   -3.8864    5.2585    0.0000 C   0  0
   -2.5847    6.0040    0.0000 C   0  0
   -2.5765    7.5048    0.0000 O   0  0
   -1.2731    8.2489    0.0000 C   0  0
    0.0208    7.4899    0.0000 N   0  0
    1.3250    8.2309    0.0000 C   0  0
    1.3354    9.7309    0.0000 C   0  0
    0.0416   10.4898    0.0000 C   0  0
   -1.2626    9.7488    0.0000 C   0  0
   -2.5571   10.5082    0.0000 C   0  0
   -3.8625    9.7693    0.0000 C   0  0
   -5.1552   10.5304    0.0000 C   0  0
   -5.1424   12.0303    0.0000 N   0  0
   -3.8370   12.7692    0.0000 C   0  0
   -3.8243   14.2692    0.0000 N   0  0
   -2.5444   12.0082    0.0000 N   0  0
   -1.2883    5.2495    0.0000 C   0  0
   -1.2935    3.7495    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 27 29  2  0
 29 23  1  0
 15 30  1  0
 30 31  2  0
 31 12  1  0
 10 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37  7  1  0
 37 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28615

> <plate>
Kinase v5-2

> <well>
L03

> <supplier_cmpd_name>
AMG 900

> <ctcr_id>
3938

> <supplier_cmpd_id>
S2719

> <smiles>
Cc1csc(c1)c2nnc(Nc3ccc(Oc4ncccc4c5ccnc(N)n5)cc3)c6ccccc26

> <pd_targets>
{AURKC,AURKB,AURKA}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Aurora kinase (Aur) family"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Mitotic,"RNA Polymerase II Transcription","M Phase","Generic Transcription Pathway","Mitotic Metaphase and Anaphase","Transcriptional Regulation by TP53
","Mitotic Anaphase","Regulation of TP53 Activity","Separation of Sister Chromatids","Regulation of TP53 Activity through Phosphorylation"}

> <broad_targets>
{AURKA,AURKB,AURKC}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{AMG-900,AMG900,"AMG 900",945595-80-2,945595802,UNII-9R2G075611,UNII9R2G075611,9R2G075611,ZINC43208325,cc-2,cc2,MLS006011192,SCHEMBL503564,C28H21N7OS,GTPL8060,CHEMBL2140408,AMG900/AMG-900,AMG900/AMG90
0,DTXSID90241526,HMS3656H17,BCP02552,EX-A1793,EXA1793,ABP000946,BDBM50466803,NSC761069,NSC799331,T6380,S2719}

> <pdid>
PD003228

> <targets>
{"Aurora Kinase"}

> <classes>
{Cell Cycle,Cell Cycle/DNA Damage,Epigenetics}

> <pubchem_cids>
{24856041}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 36  0  0  0  0            999 V2000
    0.9513   -6.4982    0.0000 C   0  0
    1.8372   -5.2877    0.0000 C   0  0
    3.3372   -5.2929    0.0000 C   0  0
    3.8056   -3.8679    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.3786   -3.8595    0.0000 N   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.6011   -3.0008    0.0000 N   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -7.8061   -5.9891    0.0000 O   0  0
   -7.8091   -7.4899    0.0000 C   0  0
   -9.1099   -8.2385    0.0000 C   0  0
   -9.2529   -9.7188    0.0000 S   0  0
  -10.7212  -10.0256    0.0000 C   0  0
  -11.4667   -8.7240    0.0000 C   0  0
  -10.4592   -7.6128    0.0000 N   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -7.7966   -2.9860    0.0000 Cl  0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  3
  6  2  1  0
  5  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 23  2  0
 20 28  1  0
 28 29  1  0
 28 30  2  0
 30 17  1  0
 15 31  1  0
 31 11  1  0
 31 32  2  0
 32  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28616

> <plate>
Kinase v5-2

> <well>
L05

> <supplier_cmpd_name>
ARRY334543

> <ctcr_id>
3076

> <supplier_cmpd_id>
S2755

> <smiles>
CC1COC(=N1)Nc2ccc3ncnc(Nc4ccc(OCc5sccn5)c(Cl)c4)c3c2

> <pd_targets>
{EGFR,ERBB2,ERBB4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Neuronal System","Signaling by GPCR","Nervous system development","Transmission across Chemical Synapses","GPCR downstream signalling","Axon guidance","
Neurotransmitter receptors and postsynaptic signal transmission","G alpha (q) signalling events","Semaphorin interactions","Activation of NMDA receptors and postsynaptic events","Gastrin-CREB signalli
ng pathway via PKC and MAPK","Sema4D in semaphorin signaling","Post NMDA receptor activation events","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone collapse","Long-te
rm potentiation"}

> <broad_targets>
{ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{"ARRY-334543; ASLAN001","ARRY334543; ASLAN001",SCHEMBL1384041,HMS3656D04,BCP02574,NCGC00389540-02,NCGC0038954002,FT-0772190,FT0772190,Y0288,S2755,ARRY334543,Varlitinib}

> <pdid>
PD010682

> <targets>
{EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{11655699}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -2.5205    6.1100    0.0000 C   0  0
   -2.0570    7.5366    0.0000 C   0  0
   -2.9352    8.7505    0.0000 N   0  0
   -2.3228   10.1207    0.0000 C   0  0
   -0.8307   10.2749    0.0000 O   0  0
   -3.2024   11.3367    0.0000 C   0  0
   -2.5923   12.7071    0.0000 C   0  0
   -3.4740   13.9207    0.0000 C   0  0
   -4.9658   13.7639    0.0000 C   0  0
   -5.5759   12.3936    0.0000 C   0  0
   -4.6943   11.1801    0.0000 C   0  0
   -5.8479   14.9781    0.0000 N   0  0
   -5.2400   16.3494    0.0000 C   0  0
   -6.1235   17.5616    0.0000 C   0  0
   -5.5155   18.9329    0.0000 C   0  0
   -7.6151   17.4025    0.0000 N   0  0
   -8.2230   16.0312    0.0000 C   0  0
   -9.7146   15.8721    0.0000 C   0  0
   -7.3395   14.8191    0.0000 C   0  0
   -0.5570    7.5366    0.0000 N   0  0
   -0.0935    6.1100    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 O   0  0
   -2.5951   -3.0031    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 24 25  1  0
 25 26  1  0
 25 27  1  0
 27 20  1  0
 10 28  2  0
 28 29  1  0
 29  8  1  0
  5 30  2  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 31 34  2  0
 34  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28617

> <plate>
Kinase v5-2

> <well>
L07

> <supplier_cmpd_name>
AZD4547

> <ctcr_id>
7249

> <supplier_cmpd_id>
S2801

> <smiles>
COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N4CC(C)NC(C)C4)n[nH]2)cc(OC)c1

> <pd_targets>
{FGFR1,FGFR2,FGFR4,FGFR3,KDR,AURKA,IGF1R}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","Tyrosine protein kinase FGFR family","Tyrosine protein kinase VEGFR family","Other protein kinase AUR family","T
yrosine protein kinase InsR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kinases (RTKs)","Aurora kinase (Aur) family","Type V RTKs: FGF (fibroblast growth f
actor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","RNA Polyme
rase II Transcription","Signaling by FGFR in disease","Signaling by FGFR","Signaling by VEGF","Generic Transcription Pathway","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Signa
ling by FGFR1 in disease","Signaling by FGFR2 in disease","Signaling by FGFR4","Signaling by FGFR3 in disease","VEGFA-VEGFR2 Pathway","Transcriptional Regulation by TP53","IGF1R signaling cascade","FG
FR1 mutant receptor activation","FGFR2 mutant receptor activation","Downstream signaling of activated FGFR4","Signaling by FGFR3 point mutants in cancer","VEGFR2 mediated cell proliferation","Regulati
on of TP53 Activity","IRS-related events triggered by IGF1R","Signaling by activated point mutants of FGFR1","Activated point mutants of FGFR2","FRS-mediated FGFR4 signaling","FGFR3 mutant receptor ac
tivation","Regulation of TP53 Activity through Phosphorylation","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{AZD4547,1035270-39-3,1035270393,AZD-4547,"AZD 4547",UNII-2167OG1EKJ,UNII2167OG1EKJ,2167OG1EKJ,CHEBI:63453,66T,KB-74810,KB74810,Tube729,SCHEMBL63884,GTPL7707,QCR-89,QCR89,SCHEMBL15250892,DTXSID8014588
7,AMY16612,AOB87745,EX-A1578,EXA1578,2240AH,ABP000893,MFCD22580423,NSC764239,NSC765338,NSC799346,T1948,13111,S2801}

> <pdid>
PD003475

> <targets>
{FGFR}

> <classes>
{}

> <pubchem_cids>
{51039095}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 41  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -6.5018    3.7420    0.0000 N   0  0
   -7.7993    2.9876    0.0000 C   0  0
   -9.1021    3.7310    0.0000 C   0  0
  -10.3974    2.9744    0.0000 C   0  0
  -10.3898    1.4745    0.0000 N   0  0
   -9.0870    0.7310    0.0000 C   0  0
   -7.7918    1.4876    0.0000 N   0  0
  -11.7024    3.7156    0.0000 N   0  0
  -11.7126    5.2156    0.0000 C   0  0
  -12.9973    2.9568    0.0000 C   0  0
  -12.9871    1.4568    0.0000 O   0  0
  -14.3024    3.6979    0.0000 N   0  0
  -15.5972    2.9391    0.0000 C   0  0
  -16.9027    3.6780    0.0000 C   0  0
  -16.9155    5.1779    0.0000 Cl  0  0
  -18.1953    2.9170    0.0000 C   0  0
  -19.5029    3.6536    0.0000 O   0  0
  -20.7944    2.8907    0.0000 C   0  0
  -18.1825    1.4170    0.0000 C   0  0
  -16.8771    0.6781    0.0000 C   0  0
  -16.8675   -0.8227    0.0000 O   0  0
  -18.1612   -1.5819    0.0000 C   0  0
  -15.5845    1.4391    0.0000 C   0  0
  -14.2792    0.7002    0.0000 Cl  0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  6  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 16 20  1  0
 20 21  1  0
 20 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 28 31  2  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 32 35  2  0
 35 25  1  0
 35 36  1  0
 12 37  1  0
 37 38  2  0
 38  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28618

> <plate>
Kinase v5-2

> <well>
L09

> <supplier_cmpd_name>
BGJ398 (NVP-BGJ398)

> <ctcr_id>
6221

> <supplier_cmpd_id>
S2183

> <smiles>
CCN1CCN(CC1)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)cc2

> <pd_targets>
{FYN,LCK,KDR,ABL1,FGFR4,LYN,YES1,FGFR2,FGFR3,JAK2,KIT,FGFR1,BMX,TYK2,NTRK2,INSR,SRC,RET,MET,TEK,MST1R,ROS1,SMO,SYK,EPHB1,FLT1,FLT4,ALK,PDGFRA,FLT3,BRAF}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor",Kinase,"Frizzled family G protein-coupled receptor","Protein Kinase","Smoothened receptor (frizzled family GPCR)","TK protein kinase group","TKL protein kinase group","Tyro
sine protein kinase Src family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Abl family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase JakA family","Tyrosine protei
n kinase PDGFR family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Trk family","Tyrosine protein kinase InsR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Met
 family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Sev family","Tyrosine protein kinase Syk family","Tyrosine protein kinase Eph family","TKL protein kinase STKR family","TKL prote
in kinase RAF family","Tyrosine protein kinase SrcA","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","G protein-coupled receptors","Receptor kinases","Class Frizzled GPCRs","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Non-receptor tyrosine kinases (nRTKs)","Rece
ptor tyrosine kinases (RTKs)","RAF family","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Abl family","Type V RTKs: FGF (fibroblast growth factor) receptor fam
ily","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Tec family","Type VII RTKs: Neurotrophin receptor/Trk family","Type II RTKs: Insulin receptor family","Type XI
V RTKs: RET","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Type XVII RTKs: ROS receptors","Syk family","Type XIII RTKs: Ephrin re
ceptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Cell Cycle",Metabolism,"Immune System","Developmental Biology","Organelle biogenesis and maintenance","Infectious disease","Signaling by Receptor Tyrosine Kinases","Dis
eases of signal transduction by growth factor receptors and second messengers",Mitotic,"Metabolism of lipids","Cytokine Signaling in Immune system","Intracellular signaling by second messengers","Nerv
ous system development","MAPK family signaling cascades","Cilium Assembly","HIV Infection","Signaling by VEGF","Leishmania infection","Signaling by FGFR","Signaling by FGFR in disease","Mitotic G1 pha
se and G1/S transition","Signaling by KIT in disease","Phospholipid metabolism","Interferon Signaling","Signaling by NTRKs","PIP3 activates AKT signaling","Axon guidance","MAPK1/MAPK3 signaling","Sign
aling by MST1","Cargo trafficking to the periciliary membrane","Signaling by PDGFR in disease","Signaling by Insulin receptor","Host Interactions of HIV factors","VEGFA-VEGFR2 Pathway","Parasite infec
tion","Signaling by FGFR4","Leishmania parasite growth and survival","Signaling by FGFR2 in disease","Signaling by FGFR3 in disease","G1 Phase","Drug resistance of KIT mutants","Signaling by FGFR1 in 
disease","PI Metabolism","Interferon alpha/beta signaling","Signaling by NTRK1 (TRKA)","Negative regulation of the PI3K/AKT network","RET signaling","Semaphorin interactions","RAF/MAP kinase cascade",
"BBSome-mediated cargo-targeting to cilium","EPH-Ephrin signaling","VEGF ligand-receptor interactions","Drug resistance of PDGFR mutants","Insulin receptor signalling cascade","The role of Nef in HIV-
1 replication and disease pathogenesis","VEGFR2 mediated cell proliferation","Leishmania phagocytosis","Downstream signaling of activated FGFR4","Anti-inflammatory response favouring Leishmania parasi
te infection","FGFR2 mutant receptor activation","Signaling by FGFR3 point mutants in cancer","Cyclin D associated events in G1","Dasatinib-resistant KIT mutants","FGFR1 mutant receptor activation","S
ynthesis of PIPs at the plasma membrane","Regulation of IFNA signaling","Activation of TRKA receptors",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signalling to ERKs","Sema4D in semaphorin signa
ling","EPHB-mediated forward signaling","VEGF binds to VEGFR leading to receptor dimerization","Imatinib-resistant PDGFR mutants","IRS-mediated signalling","Nef and signal transduction","Nef-mediates 
down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated phagocytosis","FRS-mediated FGFR4 signaling","FCGR3A-mediated IL10 synthesis","Activated point mutan
ts of FGFR2","FGFR3 mutant receptor activation","Signaling by activated point mutants of FGFR1","NGF-independant TRKA activation","Signalling to RAS","Sema4D mediated inhibition of cell attachment and
 migration","PI3K Cascade","Prolonged ERK activation events","Nef Mediated CD4 Down-regulation","Signaling by activated point mutants of FGFR3","p38MAPK events","ARMS-mediated activation"}

> <broad_targets>
{FGFR1,FGFR2,FGFR3,FGFR4,KDR}

> <broad_moa>
{"FGFR inhibitor"}

> <synonyms>
{"GJ398 (NVPBGJ398",NVP-BGJ398,NVPBGJ398,Infigratinib,872511-34-7,872511347,BGJ398,BGJ-398,"BGJ 398","BGJ398 (NVP-BGJ398)","BGJ398 (NVPBGJ398)",UNII-A4055ME1VK,UNIIA4055ME1VK,"Infigratinib free base",
MVP-BGJ398,MVPBGJ398,A4055ME1VK,CHEBI:63451,"872511-34-7 (free base)","872511347 (free base)",C26H31Cl2N7O3,CHEMBL1834657,"Infigratinib (INN)",T1975,S2183}

> <pdid>
PD003222

> <targets>
{FGFR,Apoptosis}

> <classes>
{Angiogenesis,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{53235510}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    9.3115   -5.7088    0.0000 C   0  0
    8.5637   -7.0091    0.0000 C   0  0
    9.3164   -8.3066    0.0000 N   0  0
    7.0629   -7.0113    0.0000 C   0  0
    6.3152   -8.3117    0.0000 O   0  0
    6.3098   -5.7131    0.0000 O   0  0
    4.8090   -5.7153    0.0000 C   0  0
    4.0613   -7.0156    0.0000 C   0  0
    4.0559   -4.4171    0.0000 C   0  0
    2.5551   -4.4192    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 O   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -3.8939    0.7546    0.0000 C   0  0
   -5.1904    1.5090    0.0000 C   0  0
   -6.4920    0.7635    0.0000 C   0  0
   -7.9161    1.2320    0.0000 N   0  0
   -8.8020    0.0215    0.0000 C   0  0
  -10.3020    0.0267    0.0000 C   0  0
   -7.9245   -1.1951    0.0000 C   0  0
   -6.4971   -0.7365    0.0000 C   0  0
   -5.2007   -1.4909    0.0000 C   0  0
   -5.2059   -2.9909    0.0000 F   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6923   -4.0811    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 26 27  1  0
 27 22  1  0
 27 28  2  0
 28 19  1  0
 28 29  1  0
 17 30  1  0
 30 13  1  0
 30 31  2  0
 31 11  1  0
 31 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28619

> <plate>
Kinase v5-2

> <well>
L11

> <supplier_cmpd_name>
Brivanib alaninate (BMS-582664)

> <ctcr_id>
5616

> <supplier_cmpd_id>
S1138

> <smiles>
CC(N)C(=O)OC(C)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C

> <pd_targets>
{FLT1,FLT4,KDR,FGFR1,FGFR2,FGFR3,FGFR4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase FGFR family"}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
{FGFR3}

> <broad_moa>
{"FGFR inhibitor","VEGFR inhibitor"}

> <synonyms>
{SCHEMBL2263525,HMS3651K03,AKOS026750544,NCGC00389340-01,NCGC0038934001,DB-073559,DB073559,FT-0663602,FT0663602,T2576,S1138,"Brivanib Alaninate","Brivanib alaninate (BMS-582664)","Brivanib Alaninate (
BMS-582664)"}

> <pdid>
PD011119

> <targets>
{VEGFR,FGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{22508903}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
   -6.4580   -6.9843    0.0000 C   0  0
   -4.9580   -6.9919    0.0000 N   0  0
   -4.2146   -8.2947    0.0000 C   0  0
   -2.7146   -8.3023    0.0000 C   0  0
   -1.9579   -7.0071    0.0000 N   0  0
   -2.7015   -5.7043    0.0000 C   0  0
   -4.2014   -5.6967    0.0000 C   0  0
   -0.4572   -7.0123    0.0000 C   0  0
    0.2883   -8.3139    0.0000 C   0  0
    1.7883   -8.3192    0.0000 C   0  0
    2.5428   -7.0227    0.0000 C   0  0
    1.7974   -5.7210    0.0000 C   0  0
    2.5497   -4.4224    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.3114   -2.9665    0.0000 N   0  0
    2.5987    1.5004    0.0000 C   0  0
    3.8991    0.7525    0.0000 C   0  0
    5.1969    1.5046    0.0000 C   0  0
    5.1945    3.0046    0.0000 C   0  0
    3.8943    3.7525    0.0000 C   0  0
    2.5964    3.0004    0.0000 C   0  0
    6.4931    3.7571    0.0000 S   0  0
    7.7938    3.0100    0.0000 O   0  0
    6.4902    5.2571    0.0000 O   0  0
    7.7905    4.5098    0.0000 C   0  0
    0.2973   -5.7159    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 16  1  0
 21 22  1  0
 22 14  2  0
 17 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 26 29  1  0
 29 30  2  0
 29 31  2  0
 29 32  1  0
 12 33  2  0
 33  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28620

> <plate>
Kinase v5-2

> <well>
L13

> <supplier_cmpd_name>
CEP33779

> <ctcr_id>
3263

> <supplier_cmpd_id>
S2806

> <smiles>
CN1CCN(CC1)c2cccc(Nc3nc4c(cccn4n3)c5ccc(cc5)S(=O)(=O)C)c2

> <pd_targets>
{JAK2,JAK3,PTK2,CYP3A4,JAK1,ABCB1}

> <pathway_gtopdb>
{Enzyme,Transporter,Kinase,"Cytochrome P450","Primary active transporter","Protein Kinase","Cytochrome P450 family 3","ATP-binding cassette","TK protein kinase group","Cytochrome P450 family 3A","ABCB
 subfamily","Tyrosine protein kinase JakA family","Tyrosine protein kinase Fak family","Cytochrome P450 3A4"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Catalytic receptors","Cytochrome P450","ATP-binding cassette transporter family","Receptor kinases","CYP3 family","ABCB subfamily","TK: Tyrosine kinase","Non-receptor 
tyrosine kinases (nRTKs)","Janus kinase (JakA) family","Fak family"}

> <pathway_reactome>
{"Cell Cycle","Immune System",Disease,Metabolism,Mitotic,"Cytokine Signaling in Immune system","Infectious disease","Metabolism of lipids","Abacavir transport and metabolism","Mitotic G1 phase and G1/
S transition","Signaling by Interleukins","Leishmania infection","Biosynthesis of specialized proresolving mediators (SPMs)","Interferon Signaling","Abacavir transmembrane transport","G1 Phase","Inter
leukin-2 family signaling","Parasite infection","Biosynthesis of DHA-derived SPMs","Antiviral mechanism by IFN-stimulated genes","Cyclin D associated events in G1","Interleukin-15 signaling","Leishman
ia phagocytosis","Biosynthesis of maresins","ISG15 antiviral mechanism","FCGR3A-mediated phagocytosis","Biosynthesis of maresin-like SPMs"}

> <broad_targets>
{JAK2}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{CEP-33779,CEP33779,1257704-57-6,1257704576,CHEMBL2062804,C24H26N6O2S,1346168-57-7,1346168577,MLS006011248,GTPL9387,SCHEMBL2634485,BDBM99537,DTXSID30720926,SYN1156,HMS3651D13,BCP27756,EX-A1032,EXA1032
,2311AH,MFCD22683932,s2806,ZINC84727467,AKOS025404934,CCG-265001,CCG265001,CS-3439,CS3439,SB19,T6122,T2426,S2806}

> <pdid>
PD010563

> <targets>
{JAK}

> <classes>
{JAK/STAT}

> <pubchem_cids>
{57336812}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 38  0  0  0  0            999 V2000
   11.8252   -1.8845    0.0000 C   0  0
   10.8251   -0.7666    0.0000 C   0  0
   10.1194    0.4833    0.0000 C   0  0
   11.4581    1.1599    0.0000 O   0  0
   12.1347   -0.1789    0.0000 C   0  0
    9.3560   -1.0736    0.0000 C   0  0
    8.3549    0.0446    0.0000 O   0  0
    6.8858   -0.2623    0.0000 C   0  0
    5.8837    0.8539    0.0000 C   0  0
    4.4160    0.5441    0.0000 C   0  0
    3.9504   -0.8818    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    2.7345   -2.9814    0.0000 C   0  0
    4.2013   -3.2954    0.0000 N   0  0
    4.9525   -1.9980    0.0000 C   0  0
    6.4202   -1.6882    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0008    0.0000 N   0  0
   -3.8959   -3.7529    0.0000 C   0  0
   -3.8935   -5.2529    0.0000 C   0  0
   -2.5933   -6.0009    0.0000 C   0  0
   -2.5909   -7.5009    0.0000 N   0  0
   -1.2954   -5.2488    0.0000 C   0  0
   -1.2978   -3.7488    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  2  1  0
  2  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 11  1  0
 15 16  2  0
 16  8  1  0
 12 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 30 31  1  0
 31 25  1  0
 24 32  1  0
 32 20  1  0
 32 33  2  0
 33 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28621

> <plate>
Kinase v5-2

> <well>
L15

> <supplier_cmpd_name>
Crenolanib (CP-868596)

> <ctcr_id>
6853

> <supplier_cmpd_id>
S2730

> <smiles>
CC1(COC1)COc2ccc3n(cnc3c2)c4ccc5cccc(N6CCC(N)CC6)c5n4

> <pd_targets>
{FLT3,CSF1R,KIT,PDGFRB,PDGFRA}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Disease,"Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors 
and second messengers","Intracellular signaling by second messengers","Signaling by Insulin receptor","Generic Transcription Pathway","Signaling by KIT in disease","PIP3 activates AKT signaling","Sign
aling by PDGFR in disease","Insulin receptor signalling cascade","Transcriptional Regulation by VENTX","Drug resistance of KIT mutants","Negative regulation of the PI3K/AKT network","Drug resistance o
f PDGFR mutants","IRS-mediated signalling","Dasatinib-resistant KIT mutants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Imatinib-resistant PDGFR mutants","PI3K Cascade"}

> <broad_targets>
{CSF1R,FLT3,KIT,PDGFRA,PDGFRB}

> <broad_moa>
{"PDGFR tyrosine kinase receptor inhibitor"}

> <synonyms>
{"RENOLANIB (CP 868596",Crenolanib,670220-88-9,670220889,"670220 88 9","Crenolanib (CP-868596)","Crenolanib (CP868596)","Crenolanib (CP 868596)",CP-868596,CP868596,"CP 868596",ARO-002,ARO002,"ARO 002"
,UNII-LQF7I567TQ,UNIILQF7I567TQ,"UNII LQF7I567TQ","CP-868,596","CP868,596","CP 868,596","Crenolanib (USAN)",LQF7I567TQ,CP868569,"CP-868596 (Crenolanib)","CP868596 (Crenolanib)","CP 868596 (Crenolanib)
",MFCD21609260,"Crenolanib (USAN:INN)",cr,T2677,S2730}

> <pdid>
PD010692

> <targets>
{PDGFR,Autophagy,FLT3}

> <classes>
{Protein Tyrosine Kinase,Autophagy,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{10366136}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8933    3.7570    0.0000 C   0  0
    3.8933    5.2571    0.0000 C   0  0
    5.1924    6.0071    0.0000 C   0  0
    6.4914    5.2571    0.0000 C   0  0
    6.4915    3.7571    0.0000 N   0  3
    7.7905    3.0072    0.0000 O   0  5
    5.1925    3.0071    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 N   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -3.9014    3.7484    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -1.3042    3.7556    0.0000 C   0  0
   -1.3088    5.2564    0.0000 C   0  0
   -0.0126    6.0112    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 14 16  2  0
 16 10  1  0
  7 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20  3  2  0
 20  6  1  0
 18 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
M  CHG  2  14   1  15  -1
M  END
> <name>
UTKinase_V5

> <id>
28622

> <plate>
Kinase v5-2

> <well>
L17

> <supplier_cmpd_name>
Dinaciclib (SCH727965)

> <ctcr_id>
6449

> <supplier_cmpd_id>
S2768

> <smiles>
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N4CCCCC4CCO

> <pd_targets>
{CCND1,CDK4,CCNA2,CDK2,CDK1,CDK5,BRD4,CCNT1,CDK9,BRDT,CDK5R1,CCNH,CDK7,MNAT1,CCNB1,CCNE1,HSF1,CDK6,TAOK1,GSK3A,GSK3B,DYRK1B,CLK4}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein",Kinase,Reader,"Protein Kinase",Bromodomain,"CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","C
MGC protein kinase CDK5 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase group","STE protein kinase STE20 family","CMGC protein kinase GSK famil
y","CMGC protein kinase DYRK family","CMGC protein kinase CLK family","STE protein kinase TAO subfamily","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Bromodomain-containing proteins","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Enzymatic bromodomain-containin
g proteins","Non-enzymatic BRD containing proteins","Cyclin-dependent kinase (CDK) family","Bromodomain kinase (BRDK) family","CDK1 subfamily","CDK5 subfamily","CDK9 subfamily","CDK4 subfamily","STE: 
Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","STE20 family","Glycogen synthase kinase (GSK) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CL
K family","TAO subfamily","GSK subfamily","CDK7 subfamily","Dyrk1 subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Disease,"Cellular responses to external stimuli",Mitotic,"RNA Polymerase II Transcription","Infectious disease","Cellular responses to stress","Regulati
on of mitotic cell cycle","Generic Transcription Pathway","SARS-CoV Infections","HIV Infection","Mitotic G1 phase and G1/S transition","Cellular response to heat stress","APC/C-mediated degradation of
 cell cycle proteins","Transcriptional Regulation by TP53","Potential therapeutics for SARS","HIV Life Cycle","G1 Phase","HSF1-dependent transactivation","Activation of APC/C and APC/C:Cdc20 mediated 
degradation of mitotic proteins","Regulation of TP53 Activity","Late Phase of HIV Life Cycle","Cyclin D associated events in G1","Attenuation phase","APC/C:Cdc20 mediated degradation of mitotic protei
ns","Regulation of TP53 Activity through Phosphorylation","Regulation of TP53 Expression and Degradation","Transcription of the HIV genome","APC:Cdc20 mediated degradation of cell cycle proteins prior
 to satisfation of the cell cycle checkpoint","Regulation of TP53 Degradation","HIV Transcription Elongation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-mediated elongation of the HIV
-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat","M Phase","Mitotic Metaphase and Anaphase","SARS-CoV-1 Infection","Mitotic Anaphase","SARS-CoV-1 Genome Replication and Tran
scription","Separation of Sister Chromatids","Replication of the SARS-CoV-1 genome"}

> <broad_targets>
{CDK1,CDK2,CDK5,CDK9}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{"SCH 727965",Kinome_3849,Kinome3849,Kinome-3849,"Kinome 3849",CHEMBL2006674,SCHEMBL15637863,HMS3656B06,HMS3672I09,BCP03473,AKOS026750260,NCGC00387827-02,NCGC0038782702,AK547961,LS-14909,LS14909,T1912
,S2768,Dinaciclib,"Dinaciclib (SCH727965)"}

> <pdid>
PD003528

> <targets>
{CDK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{16048554}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -5.1968   -1.5004    0.0000 C   0  0
   -6.6177   -1.4570    0.0000 C   0  0
   -5.8657   -2.7548    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 N   0  0
    1.3039   -3.7494    0.0000 C   0  0
    2.6005   -2.9949    0.0000 C   0  0
    3.9021   -3.7404    0.0000 C   0  0
    3.9073   -5.2404    0.0000 C   0  0
    5.2089   -5.9859    0.0000 I   0  0
    2.6108   -5.9949    0.0000 C   0  0
    1.3092   -5.2494    0.0000 C   0  0
    0.0128   -6.0039    0.0000 F   0  0
   -2.5981    3.0007    0.0000 C   0  0
   -1.3003    3.7529    0.0000 C   0  0
   -1.3026    5.2529    0.0000 C   0  0
   -2.6029    6.0009    0.0000 C   0  0
   -3.9007    5.2488    0.0000 C   0  0
   -5.2032    5.9944    0.0000 N   0  0
   -6.5007    5.2401    0.0000 C   0  0
   -6.4957    3.7401    0.0000 C   0  0
   -7.8025    5.9854    0.0000 O   0  0
   -3.8983    3.7488    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 11  1  0
 10 14  1  0
 14 15  2  0
 14 16  1  0
 16  6  1  0
 16 17  2  3
 17  2  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
 25 26  1  0
  7 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 33 35  2  0
 31 36  2  0
 36 27  1  0
  5 37  1  0
M  END
> <name>
UTKinase_V5

> <id>
28623

> <plate>
Kinase v5-2

> <well>
L19

> <supplier_cmpd_name>
GSK1120212 (Trametinib)

> <ctcr_id>
311

> <supplier_cmpd_id>
S2673

> <smiles>
CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1Nc4ccc(I)cc4F)c5cccc(NC(C)=O)c5)C

> <pd_targets>
{MAP2K1,MAP2K2,ABCB1,BRAF}

> <pathway_gtopdb>
{Enzyme,Transporter,Kinase,"Primary active transporter","Protein Kinase","ATP-binding cassette","STE protein kinase group","ABCB subfamily","TKL protein kinase group","STE protein kinase STE7 family",
"TKL protein kinase RAF family"}

> <pathway_chembl>
{Enzymes,Transporters,Receptors,"Kinases (EC 2.7.x.x)","ATP-binding cassette transporter family","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","ABCB subfam
ily","Receptor kinases","STE7 family","TKL: Tyrosine kinase-like","RAF family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,"Signaling by Receptor Tyrosine Kinases","Abacavir transport and metabolism","Signaling by NTRKs","Abacavir transmembrane transport","Signaling by NTRK1 (TRKA)","Sign
alling to ERKs","Prolonged ERK activation events","Frs2-mediated activation","ARMS-mediated activation"}

> <broad_targets>
{MAP2K1,MAP2K2}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{Trametinib,871700-17-3,871700173,GSK1120212,Mekinist,GSK-1120212,"JTP 74057",JTP-74057,JTP74057,"GSK 1120212","Trametinib (GSK1120212)",GSK212,UNII-33E86K87QN,UNII33E86K87QN,TMT212,CHEBI:75998,TMT-21
2,33E86K87QN,"Trametinib (USAN:INN)",trametinibum,QOM,"Trametinib (USAN)",T2125,758246,S2673,trametinib,"GSK1120212 (Trametinib)"}

> <pdid>
PD003250

> <targets>
{MEK}

> <classes>
{MAPK,"Kinase inhibitor"}

> <pubchem_cids>
{11707110}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    4.9619   -2.4739    0.0000 C   0  0
    6.4015   -2.0524    0.0000 C   0  0
    6.7561   -0.5949    0.0000 C   0  0
    8.0760    0.1161    0.0000 O   0  0
    7.8072    1.5919    0.0000 C   0  0
    8.8431    2.6767    0.0000 N   0  0
    6.3207    1.7923    0.0000 N   0  0
    5.6713    0.4410    0.0000 C   0  0
    4.2318    0.0194    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 14 15  1  0
 15 10  1  0
 15 16  2  0
 16  7  1  0
  6 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23  4  1  0
 23 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28624

> <plate>
Kinase v5-2

> <well>
L21

> <supplier_cmpd_name>
INK 128

> <ctcr_id>
2906

> <supplier_cmpd_id>
S2811

> <smiles>
CC(C)n1nc(c2ccc3oc(N)nc3c2)c4c(N)ncnc14

> <pd_targets>
{PIK3CD,MTOR,PIK3CA,PIK3C3,PIK3CB,PIK3CG,MLST8,RPTOR,MAPKAP1,RICTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Phosphatidyl
inositol 3-kinase family","FRAP subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)",Disease,"Signal Transduction",Metabolism,"Cytokine Signaling in Immune system","RNA Polymerase II Transcription","Diseases of signal transduction by 
growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","Signaling by Interleukins","Generic Transcription Pathway","Signaling by FGFR in disease
","Signaling by Insulin receptor","Phospholipid metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","Insulin receptor si
gnalling cascade","PI Metabolism","Interleukin receptor SHC signaling","Regulation of TP53 Activity","FGFR1 mutant receptor activation","IRS-mediated signalling","Synthesis of PIPs at the plasma membr
ane","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR,PIK3CA,PIK3CD,PIK3CG}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{1224844-38-5,1224844385,Sapanisertib,INK-128,INK128,MLN0128,"INK 128","INK 128 (MLN0128)",TAK-228,TAK228,MLN-0128,UNII-JGH0DF1U03,UNIIJGH0DF1U03,"Sapanisertib (MLN0128)",JGH0DF1U03,C15H15N7O,"Sapanis
ertib; INK128","Sapanisertib (USAN/INN)","Sapanisertib (USAN:INN)",MLS006011012,T1838,S2811}

> <pdid>
PD010560

> <targets>
{mTOR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{45375953}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.6012    3.0008    0.0000 O   0  0
   -3.9020    3.7494    0.0000 C   0  0
   -3.9051    5.2502    0.0000 C   0  0
   -2.6918    6.1103    0.0000 N   0  0
   -3.1555    7.5368    0.0000 N   0  0
   -4.6547    7.5362    0.0000 C   0  0
   -5.6586    8.6508    0.0000 C   0  0
   -7.1258    8.3387    0.0000 C   0  0
   -7.5891    6.9120    0.0000 C   0  0
   -6.5852    5.7975    0.0000 N   0  0
   -5.1180    6.1096    0.0000 N   0  0
   -9.0570    6.5997    0.0000 C   0  0
  -10.0627    7.7126    0.0000 C   0  0
  -11.5294    7.3982    0.0000 C   0  0
  -11.9904    5.9708    0.0000 C   0  0
  -10.9848    4.8578    0.0000 C   0  0
   -9.5181    5.1723    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 10  1  0
 18 13  1  0
 16 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
  7 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28  6  1  0
 28 29  2  0
 29  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28625

> <plate>
Kinase v5-2

> <well>
N03

> <supplier_cmpd_name>
AMG-208

> <ctcr_id>
6105

> <supplier_cmpd_id>
S1316

> <smiles>
COc1ccc2c(OCc3nnc4ccc(nn34)c5ccccc5)ccnc2c1

> <pd_targets>
{MET,CYP3A4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 3","TK protein kinase group","Cytochrome P450 family 3A","Tyrosine protein kinase Met family","Cytochrome P450 3A4"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Cytochrome P450","Receptor kinases","CYP3 family","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) recept
or family"}

> <pathway_reactome>
{"Developmental Biology",Metabolism,"Nervous system development","Metabolism of lipids","Axon guidance","Biosynthesis of specialized proresolving mediators (SPMs)","Semaphorin interactions","Biosynthe
sis of DHA-derived SPMs","Sema4D in semaphorin signaling","Biosynthesis of maresins","Sema4D mediated inhibition of cell attachment and migration","Biosynthesis of maresin-like SPMs"}

> <broad_targets>
{MET}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{MG20,AMG-208,AMG208,1002304-34-8,1002304348,"AMG 208",UNII-Y2SR66P7VM,UNIIY2SR66P7VM,Y2SR66P7VM,CHEBI:90626,C22H17N5O2,"Triazolopyridazine, 4",3cd8,cc-218,cc218,CHEMBL496102,SCHEMBL9910136,BDBM24470,
AMG-208/AMG208,AMG208/AMG208,DTXSID70143039,QCR-184,QCR184,BCP01384,EX-A4656,EXA4656,ABP000136,NSC766288,NSC801016,T6260,S1316}

> <pdid>
PD004808

> <targets>
{c-Met,c-Met/HGFR,"Cytochrome P450"}

> <classes>
{Metabolic Enzyme/Protease,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{24864821}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 46  0  0  0  0            999 V2000
    7.7988   -1.4819    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 C   0  0
   -2.5112   -6.1125    0.0000 O   0  0
   -2.0454   -7.5384    0.0000 C   0  0
   -2.9216   -8.7537    0.0000 C   0  0
   -2.3070  -10.1229    0.0000 N   0  0
   -3.1847  -11.3404    0.0000 C   0  0
   -2.5701  -12.7096    0.0000 C   0  0
   -3.4478  -13.9270    0.0000 S   0  0
   -2.8335  -15.2954    0.0000 O   0  0
   -4.9401  -13.7752    0.0000 O   0  0
   -4.3256  -15.1433    0.0000 C   0  0
   -0.5454   -7.5360    0.0000 C   0  0
   -0.0841   -6.1087    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    7.7876    1.5211    0.0000 O   0  0
    7.7802    3.0220    0.0000 C   0  0
    9.0740    3.7810    0.0000 C   0  0
    9.0637    5.2810    0.0000 C   0  0
    7.7595    6.0220    0.0000 N   0  0
    7.4379    7.4863    0.0000 N   0  0
    5.9450    7.6327    0.0000 C   0  0
    5.3444    6.2582    0.0000 N   0  0
    6.4656    5.2630    0.0000 C   0  0
    6.4760    3.7630    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
 13 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  2  0
 23 26  1  0
 18 27  2  0
 27 28  1  0
 28 16  2  0
  4 29  2  0
 29 30  1  0
 30 31  2  0
 31  2  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  1  0
 37 38  2  0
 38 39  1  0
 39 40  2  0
 40 36  1  0
 40 41  1  0
 41 33  2  0
M  END
> <name>
UTKinase_V5

> <id>
28626

> <plate>
Kinase v5-2

> <well>
N05

> <supplier_cmpd_name>
Arry-380

> <ctcr_id>
5591

> <supplier_cmpd_id>
S2752

> <smiles>
Cc1cc(Nc2ncnc3ccc(cc23)c4oc(CNCCS(=O)(=O)C)cc4)ccc1Oc5ccn6ncnc6c5

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{ER2INHIBITOR,Arry-380,Arry380,937265-83-3,937265833,HER2-Inhibitor-1,HER2Inhibitor1,"ARRY-380 (analog )","ARRY380 (analog )","ARRY-380 Analog","ARRY380 Analog",UNII-H32S1659ED,UNIIH32S1659ED,"Arry 38
0",H32S1659ED,"937265-83-3 (ARRY-380 analog)","937265833 (ARRY380 analog)","HER2 Inhibitor 1",cc-595,cc595,CHEMBL4303303,SCHEMBL10169911,C29H27N7O4S,DTXSID00239555,T2518,S2752,ARRY380}

> <pdid>
PD012935

> <targets>
{HER2,EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{42598643}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    3.1284    1.5817    0.0000 C   0  0
    4.2506    0.5865    0.0000 C   0  0
    5.6735    1.0612    0.0000 C   0  0
    3.9511   -0.8815    0.0000 N   0  0
    4.9531   -1.9978    0.0000 C   0  0
    6.4451   -1.8434    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    2.7343   -2.9815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
   -2.5795   -7.5048    0.0000 S   0  0
   -1.2776   -8.2499    0.0000 C   0  0
   -3.8755   -8.2601    0.0000 O   0  0
   -2.5736   -9.0048    0.0000 O   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 19 22  1  0
 22 23  1  0
 22 24  2  0
 22 25  2  0
 14 26  2  0
 26 10  1  0
M  END
> <name>
UTKinase_V5

> <id>
28627

> <plate>
Kinase v5-2

> <well>
N07

> <supplier_cmpd_name>
AZD5438

> <ctcr_id>
3657

> <supplier_cmpd_id>
S2621

> <smiles>
CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)[S](C)(=O)=O)n2

> <pd_targets>
{CCNT1,KCNH2,CDK1,CCNA2,CCND3,CDK4,CDK9,CCNE1,CDK2,CCNB1,CDK10,CDK11B,CDK12,CDK13,CDK14,CDK15,CDK16,CDK17,CDK18,CDK19,CDK20,CDK3,CDK5,CDK6,CDK7,CDK8}

> <pathway_gtopdb>
{"Other cytosolic protein","Ion channel",Enzyme,"Voltage-gated ion channel",Kinase,"Potassium channels","Protein Kinase","Voltage-gated potassium channel","CMGC protein kinase group","CMGC protein kin
ase CDK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{"Ion channels",Enzymes,"Voltage-gated ion channels","Kinases (EC 2.7.x.x)","Potassium channels","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Voltage-gated potassium channels","Cyclin-dependent ki
nase (CDK) family","CDK1 subfamily","CDK4 subfamily","CDK9 subfamily"}

> <pathway_reactome>
{Disease,"Muscle contraction","Cell Cycle","Gene expression (Transcription)","Infectious disease","Cardiac conduction",Mitotic,"RNA Polymerase II Transcription","HIV Infection","Phase 3 - rapid repola
risation","Regulation of mitotic cell cycle","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","M Phase","HIV Life Cycle","APC/C-mediated degradation of cell cycle proteins","G1 P
hase","G1/S Transition","Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase","Late Phase of HIV Life Cycle","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic protei
ns","Cyclin D associated events in G1","Cyclin E associated events during G1/S transition","Regulation of TP53 Activity","Mitotic Anaphase","Transcription of the HIV genome","APC/C:Cdc20 mediated degr
adation of mitotic proteins","Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes","Regulation of TP53 Expression and Degradation","Nuclear Envelope (NE) Reassemb
ly","HIV Transcription Elongation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Regulation of TP53 Degradation","Initiation of Nuclear Env
elope (NE) Reformation","Tat-mediated elongation of the HIV-1 transcript","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{KCNH2}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{602306-29-6,602306296,AZD5438,"AZD 5438",AZD-5438,CHEMBL488436,UNII-276Z913G29,UNII276Z913G29,MMV676604,276Z913G29,C18H21N5O2S,PubChem19336,cc-215,cc215,MLS006011033,GTPL8473,SCHEMBL5092360,CHEBI:914
19,AMY2766,AOB2219,EX-A069,EXA069,BCPP000368,HMS3295K15,HMS3656B05,HMS3750K15,ACT06825,T2506,S2621}

> <pdid>
PD010916

> <targets>
{CDK}

> <classes>
{Cell Cycle,Cell Cycle/DNA Damage}

> <pubchem_cids>
{16747683}

$$$$
UTKinase_V5
  SciTegic11012413002D

 45 50  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    2.6003    1.4978    0.0000 C   0  0
    3.8983    0.7459    0.0000 C   0  0
    2.6029    2.9978    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -1.3022    5.2508    0.0000 N   0  0
   -2.6030    5.9994    0.0000 C   0  0
   -3.8995    5.2449    0.0000 C   0  0
   -5.2011    5.9904    0.0000 C   0  0
   -5.2063    7.4904    0.0000 C   0  0
   -3.9099    8.2449    0.0000 C   0  0
   -2.6083    7.4994    0.0000 C   0  0
   -1.3127    8.2570    0.0000 O   0  0
   -1.3201    9.7570    0.0000 C   0  0
   -6.5071    8.2390    0.0000 C   0  0
   -7.8049    7.4868    0.0000 O   0  0
   -6.5102    9.7398    0.0000 N   0  0
   -7.8110   10.4884    0.0000 C   0  0
   -7.8163   11.9884    0.0000 C   0  0
   -9.1179   12.7339    0.0000 C   0  0
  -10.4143   11.9795    0.0000 C   0  0
  -10.4092   10.4795    0.0000 C   0  0
   -9.1076    9.7340    0.0000 C   0  0
  -11.7166   12.7254    0.0000 N   0  0
  -11.7242   14.2254    0.0000 C   0  0
  -13.0270   14.9689    0.0000 C   0  0
  -14.3223   14.2124    0.0000 N   0  0
  -14.3147   12.7124    0.0000 C   0  0
  -13.0119   11.9689    0.0000 C   0  0
  -15.6273   14.9536    0.0000 C   0  0
  -16.9222   14.1948    0.0000 C   0  0
  -18.3434   14.2283    0.0000 C   0  0
  -17.5823   12.9357    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  5  7  1  0
  4  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 17 18  1  0
 18 19  1  0
 15 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 23  1  0
 26 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 29  1  0
 32 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 36  1  0
 10 39  2  0
 39 40  1  0
 40 41  2  0
 41  8  1  0
 41 42  1  0
 42 43  1  0
 42 44  1  0
 44  3  1  0
 44 45  2  0
M  END
> <name>
UTKinase_V5

> <id>
28628

> <plate>
Kinase v5-2

> <well>
N09

> <supplier_cmpd_name>
BI6727 (Volasertib)

> <ctcr_id>
1622

> <supplier_cmpd_id>
S2235

> <smiles>
CCC1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)ncc2N(C)C1=O

> <pd_targets>
{PLK1,BRD4}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,"Protein Kinase",Bromodomain,"Other protein kinase group","Other protein kinase PLK family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Chromatin modifying enzymes","Receptor kinases","Enzymatic bromodomain-containing proteins","Other protein kinases","Bromodomain kinase (BRDK) family","Polo-l
ike kinase (PLK) family"}

> <pathway_reactome>
{"Cell Cycle",Disease,Mitotic,"Infectious disease","Mitotic G2-G2/M phases","SARS-CoV Infections","G2/M Transition","Potential therapeutics for SARS","Centrosome maturation","Loss of proteins required
 for interphase microtubule organization from the centrosome","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{PLK1}

> <broad_moa>
{"PLK inhibitor"}

> <synonyms>
{"BI 6727; Volasertib",Bi6727(volasertib),CHEMBL2134625,SCHEMBL14136759,SCHEMBL18636896,SCHEMBL18636919,SCHEMBL18637304,HMS3655J14,HMS3673G19,HMS3745K21,VA12006,NCGC00387812-03,NCGC0038781203,FT-07705
19,FT0770519,T6019,S2235,Volasertib,"BI6727 (Volasertib)","Volasertib (BI 6727)"}

> <pdid>
PD010810

> <targets>
{PLK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{71080313}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 32  0  0  0  0            999 V2000
    4.2566    0.5871    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.8054   -4.6666    0.0000 N   0  0
    3.9195   -5.8781    0.0000 C   0  0
    2.4283   -5.7163    0.0000 O   0  0
    4.5250   -7.2514    0.0000 N   0  0
    5.9828   -7.5456    0.0000 C   0  0
    6.1372   -9.0377    0.0000 C   0  0
    4.7659   -9.6456    0.0000 C   0  0
    3.7640   -8.5292    0.0000 C   0  0
    2.2730   -8.6751    0.0000 C   0  0
    1.6521  -10.0406    0.0000 O   0  0
    1.4005   -7.4550    0.0000 N   0  0
    2.7343   -2.9815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988   -1.5004    0.0000 C   0  0
   -2.5983   -3.0004    0.0000 C   0  0
   -1.2996   -2.2502    0.0000 C   0  0
   -3.8990   -0.7508    0.0000 C   0  0
   -5.1981   -1.5008    0.0000 F   0  0
   -3.8995    0.7492    0.0000 F   0  0
   -5.1982   -0.0010    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  8  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
  4 16  1  0
 16 17  1  0
 17  2  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 22 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
 27 28  1  0
 27 29  1  0
 27 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28629

> <plate>
Kinase v5-2

> <well>
N11

> <supplier_cmpd_name>
BYL719

> <ctcr_id>
3900

> <supplier_cmpd_id>
S2814

> <smiles>
Cc1nc(NC(=O)N2CCCC2C(=O)N)sc1c3ccnc(c3)C(C)(C)C(F)(F)F

> <pd_targets>
{PIK3CA,PIK3CG,PIK3CD,PIK3CB}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{Disease,Metabolism,"Immune System","Signal Transduction","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","Cytokine Signaling in Immune system
","Signaling by Receptor Tyrosine Kinases","Signaling by FGFR in disease","Phospholipid metabolism","Signaling by Interleukins","Signaling by Insulin receptor","Signaling by FGFR1 in disease","PI Meta
bolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membrane","Interleukin receptor SHC
 signaling","IRS-mediated signalling","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade"}

> <broad_targets>
{PIK3CA,PIK3CB,PIK3CD,PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{SCHEMBL16933192,HMS3656J12,HMS3672E21,BCP06730,AKOS026750265,NCGC00389618-01,NCGC0038961801,AK146107,FT-0700120,FT0700120,S2814,BYL719}

> <pdid>
PD003252

> <targets>
{PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{75163532}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 41  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 O   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.7124    4.0029    0.0000 N   0  0
   -3.1023    5.3733    0.0000 C   0  0
   -3.7126    6.7423    0.0000 C   0  0
   -2.8309    7.9559    0.0000 C   0  0
   -1.3391    7.7991    0.0000 C   0  0
   -0.7290    6.4288    0.0000 C   0  0
   -1.6105    5.2165    0.0000 C   0  0
   -3.4413    9.3269    0.0000 C   0  0
   -4.0514   10.6972    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8791    2.2804    0.0000 C   0  0
   -2.5628    0.0004    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 N   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
    0.0072   -7.5016    0.0000 N   0  0
   -1.2895   -8.2559    0.0000 C   0  0
   -1.2847   -9.7558    0.0000 C   0  0
    0.0167  -10.5017    0.0000 O   0  0
    1.3133   -9.7476    0.0000 C   0  0
    1.3086   -8.2476    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  8  1  0
 16 11  1  0
 13 17  1  0
 17 18  3  0
  9 19  1  0
 19 20  1  0
 19 21  1  0
 19 22  1  0
 22  5  2  0
 22 23  1  0
 23 24  2  0
 24  3  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 25  1  0
 28 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28630

> <plate>
Kinase v5-2

> <well>
N13

> <supplier_cmpd_name>
CH5424802

> <ctcr_id>
584

> <supplier_cmpd_id>
S2762

> <smiles>
CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N5CCC(CC5)N6CCOCC6

> <pd_targets>
{KDR,MET,ROS1,ALK,SRPK1,RET,EML4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","CMGC protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Met family","Tyrosine p
rotein kinase Sev family","TKL protein kinase STKR family","CMGC protein kinase SRPK family","Tyrosine protein kinase Ret family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","SRPK family","Receptor tyrosine kinases (RTKs)
","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XVII RTKs: ROS receptors","Type XIX RTKs: Leukocyte tyro
sine kinase (LTK) receptor family","Type XIV RTKs: RET"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Signaling by Receptor Tyrosine Kinases","Nervous system development","Signaling by VEGF","Axon guidance","VEGFA-VEGFR2 Pathway","Semaphorin interactions
","RET signaling","VEGFR2 mediated cell proliferation","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{ALK,MET}

> <broad_moa>
{"ALK tyrosine kinase receptor inhibitor"}

> <synonyms>
{Alectinib,1256580-46-7,1256580467,CH5424802,Alecensa,"CH 5424802",AF-802,AF802,UNII-LIJ4CT1Z3Y,UNIILIJ4CT1Z3Y,"Alectinib (CH5424802)",RO5424802,"Alectinib free base","AF 802",LIJ4CT1Z3Y,CH-5424802,CH
EMBL1738797,"1256580-46-7 (free base)","1256580467 (free base)",C30H34N4O2,"Alectinib (USAN:INN)",EMH,T1936,764040,S2762}

> <pdid>
PD003223

> <targets>
{ALK}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{49806720}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 38  0  0  0  0            999 V2000
    3.9254   -5.8780    0.0000 C   0  0
    4.8082   -4.6653    0.0000 C   0  0
    6.2998   -4.8240    0.0000 C   0  0
    5.4168   -6.0363    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 N   0  0
   -3.8990   -0.7455    0.0000 S   0  0
   -3.8964    0.7545    0.0000 O   0  0
   -2.5988    0.0025    0.0000 O   0  0
   -5.2003   -1.4932    0.0000 C   0  0
   -5.2034   -2.9932    0.0000 C   0  0
   -3.9059   -3.7459    0.0000 F   0  0
   -6.5040   -3.7406    0.0000 C   0  0
   -7.8015   -2.9879    0.0000 C   0  0
   -7.7984   -1.4879    0.0000 C   0  0
   -6.4978   -0.7406    0.0000 C   0  0
   -6.4947    0.7594    0.0000 F   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 F   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 S   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 N   0  0
    6.1382    2.3782    0.0000 C   0  0
    7.5955    2.7333    0.0000 N   0  0
    5.7171    0.9385    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  2  0
 14 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 17  1  0
 23 24  1  0
 12 25  2  0
 25  8  1  0
 25 26  1  0
  7 27  2  0
 27 28  1  0
 28  5  1  0
 27 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  1  0
 33 35  2  0
 35 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28631

> <plate>
Kinase v5-2

> <well>
N15

> <supplier_cmpd_name>
Dabrafenib (GSK2118436)

> <ctcr_id>
6573

> <supplier_cmpd_id>
S2807

> <smiles>
CC(C)(C)c1nc(c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)c4ccnc(N)n4

> <pd_targets>
{RIPK1,BRAF,DSTYK,RIPK2,RIPK3,ARAF,KRAS,TGFBR1,RAF1,SIK1,NEK11,LIMK1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","TKL protein kinase group","CAMK protein kinase group","Other protein kinase group","TKL protein kinase RIPK family","TKL protein kinase RAF fami
ly","TKL protein kinase STKR family","CAMK protein kinase CAMK1 family","Other protein kinase NEK family","TKL protein kinase LISK family","TKL protein kinase STKR Type 1 subfamily","CAMK protein kina
se QIK subfamily","Other protein kinase Nek11","TKL protein kinase LIMK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","3.6.5.2 Small monomeric GTPases","Kinases (EC 2.7.x.x)","Receptor kinases","RAS subfamily","CAMK: Calcium/calmodulin-dependent protein kinases","TKL: Tyrosine
 kinase-like","Other protein kinases","CAMK-like (CAMKL) family","Receptor interacting protein kinase (RIPK) family","RAF family","Other-unique family","Receptor serine/threonine kinase (RSTK) family"
,"QIK subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","LIM domain kinase (LISK) family","Type I receptor serine/threonine kinases","LIMK subfamily"}

> <pathway_reactome>
{"Immune System","Signal Transduction",Disease,"Neuronal System","Circadian Clock","Developmental Biology","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduct
ion by growth factor receptors and second messengers","Transmission across Chemical Synapses","MAPK family signaling cascades","Nervous system development","Toll-like Receptor Cascades","Signaling by 
NTRKs","Oncogenic MAPK signaling","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by TGF-beta Receptor Complex in Cancer","MAPK1/MAPK3 signaling","Axon guidance","Toll Lik
e Receptor 4 (TLR4) Cascade","Signaling by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) Cascade","Signaling by RAS mutants","Activation of NMDA receptors and postsynaptic events","Loss of Function of SM
AD2/3 in Cancer","RAF/MAP kinase cascade","Semaphorin interactions","MyD88-independent TLR4 cascade","Signalling to ERKs","MyD88 cascade initiated on plasma membrane","Signaling downstream of RAS muta
nts","Post NMDA receptor activation events","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Negative regulation of MAPK pathway","Sema4D in semaphorin signaling","TRIF(TICAM1)-mediated TLR4 signali
ng","Prolonged ERK activation events","MAP kinase activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Negative feedback regulation of MAPK pathway","Sema4D 
induced cell migration and growth-cone collapse","IKK complex recruitment mediated by RIP1","ARMS-mediated activation","activated TAK1 mediates p38 MAPK activation","Ras activation upon Ca2+ influx th
rough NMDA receptor"}

> <broad_targets>
{BRAF,LIMK1,NEK11,RAF1,SIK1}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{Dabrafenib,1195765-45-7,1195765457,Tafinlar,"Dabrafenib (GSK2118436)",GSK2118436A,UNII-QGP4HA4G1B,UNIIQGP4HA4G1B,"Dabrafenib (Free Base)",QGP4HA4G1B,"GSK 2118436","1195765-45-7 (free base)","11957654
57 (free base)",CHEBI:75045,Dabrafenib-d9,Dabrafenibd9,GSK-2118436,GSK2118436,GSK-2118436A,"Dabrafenib Mesylate (GSK-2118436)","Dabrafenib Mesylate (GSK2118436)",T1903,16989,S2807,dabrafenib}

> <pdid>
PD003542

> <targets>
{Raf}

> <classes>
{MAPK}

> <pubchem_cids>
{44462760}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    1.2879   -5.2349    0.0000 C   0  0
    2.5834   -5.9910    0.0000 C   0  0
    2.5758   -7.4910    0.0000 C   0  0
    3.8871   -5.2475    0.0000 N   0  0
    5.1833   -6.0040    0.0000 C   0  0
    6.4870   -5.2605    0.0000 C   0  0
    6.4916   -3.7596    0.0000 C   0  0
    7.7931   -3.0140    0.0000 O   0  0
    5.1945   -3.0045    0.0000 N   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 C   0  0
   -3.8805   -1.4410    0.0000 O   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6924   -4.0811    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    7.7841   -6.0156    0.0000 C   0  0
    9.0880   -5.2740    0.0000 C   0  0
   10.3822   -6.0322    0.0000 C   0  0
   10.3726   -7.5322    0.0000 C   0  0
   11.6668   -8.2905    0.0000 Cl  0  0
    9.0688   -8.2739    0.0000 C   0  0
    7.7746   -7.5156    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14  9  1  0
 12 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 25 15  1  0
 25 19  2  0
  6 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 29 31  1  0
 31 32  2  0
 32 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28632

> <plate>
Kinase v5-2

> <well>
N17

> <supplier_cmpd_name>
GDC-0068

> <ctcr_id>
6785

> <supplier_cmpd_id>
S2808

> <smiles>
CC(C)NCC(C(=O)N1CCN(CC1)c2ncnc3C(O)CC(C)c23)c4ccc(Cl)cc4

> <pd_targets>
{AKT2,AKT3,AKT1,PRKG1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase AKT family","AGC protein kinase PKG family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Akt (Protein kinase B","PKB) family","Protein kinase G (PKG) family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Hemostasis,"Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Platelet homeostasis","Signaling by Insulin receptor","G
eneric Transcription Pathway","Nitric oxide stimulates guanylate cyclase","Insulin receptor signalling cascade","Transcriptional Regulation by TP53","cGMP effects","IRS-mediated signalling","Regulatio
n of TP53 Activity","PI3K Cascade","Regulation of TP53 Expression and Degradation","PKB-mediated events","Regulation of TP53 Degradation","PDE3B signalling"}

> <broad_targets>
{AKT1,AKT2,AKT3,PRKG1}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{MFCD22124514,SCHEMBL19867534,HMS3656F12,HMS3672G19,NCGC00387830-03,NCGC0038783003,AK174371,DA-33608,DA33608,SY272632,FT-0773211,FT0773211,T6252,S2808,Ipatasertib,GDC-0068}

> <pdid>
PD017093

> <targets>
{Akt}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{74078320}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
    3.9068   -5.2448    0.0000 C   0  0
    3.9047   -3.7448    0.0000 N   0  0
    5.2029   -2.9917    0.0000 C   0  0
    6.5032   -3.7395    0.0000 O   0  0
    5.2007   -1.4909    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    7.7988   -1.4819    0.0000 F   0  0
    6.4920    0.7636    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -5.3262    3.2720    0.0000 N   0  0
   -6.2121    4.4824    0.0000 C   0  0
   -5.3346    5.6990    0.0000 C   0  0
   -3.9073    5.2404    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -0.0136    6.0070    0.0000 O   0  0
   -0.0210    7.5070    0.0000 C   0  0
   -5.7870    1.8463    0.0000 C   0  0
   -4.7811    0.7335    0.0000 O   0  0
   -7.2543    1.5310    0.0000 C   0  0
   -7.7158    0.1029    0.0000 N   0  0
   -9.1823   -0.2122    0.0000 C   0  0
   -6.7100   -1.0099    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  5  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 19  2  0
 23 24  1  0
 24 25  2  0
 25 17  1  0
 25 26  1  0
 26 27  1  0
 20 28  1  0
 28 29  2  0
 28 30  1  0
 30 31  1  0
 31 32  1  0
 31 33  1  0
 15 34  2  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  2  0
 38 39  1  0
 39 13  1  0
 39 35  2  0
M  END
> <name>
UTKinase_V5

> <id>
28633

> <plate>
Kinase v5-2

> <well>
N19

> <supplier_cmpd_name>
GSK1838705A

> <ctcr_id>
6349

> <supplier_cmpd_id>
S2703

> <smiles>
CNC(=O)c1c(F)cccc1Nc2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN(C)C)nc5[nH]ccc25

> <pd_targets>
{STK33,DYRK1A,PTK2B,MYLK,MAPK8,MAPK10,PHKG2,CAMK4,PRKD1,JAK2,RPS6KA1,CLK1,RPS6KA2,ERBB4,AXL,CSNK1E,INSR,DCLK1,HIPK3,PHKG1,MAP3K19,HIPK1,OXSR1,EGFR,FLT3,PLK1,RIOK2,TAOK1,MAP2K4,CLK2,HIPK2,LRRK2,CLK4,PT
K2,IGF1R,STK16,TSSK1B,ALK,CHEK2,IRAK1,ROS1,GRK7,HIPK4,PRKD3,CSNK2A1,TAOK3,MAP2K3,INSRR,FES,GRK1,MAP3K7,LTK,DYRK1B,DAPK2,TNK1,RPS6KA3,MERTK,TTK,RPS6KA6,GAK,DSTYK,DAPK3,CSNK1D,DAPK1,JAK3,FER,MAPK9}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CMGC protein kinase group","TK protein kinase group","AGC protein kinase group","CK1 protein kinase group","STE protein kinase group","Othe
r protein kinase group","Atypical protein kinase group","TKL protein kinase group","CAMK protein kinase unique family","CMGC protein kinase DYRK family","Tyrosine protein kinase Fak family","CAMK prot
ein kinase MLCK family","CMGC protein kinase MAPK family","CAMK protein kinase PHk family","CAMK protein kinase CAMK1 family","CAMK protein kinase PKD family","Tyrosine protein kinase JakA family","AG
C protein kinase RSK family","CMGC protein kinase CLK family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Axl family","CK1 protein kinase CK1 family","Tyrosine protein kinase InsR f
amily","CAMK protein kinase DCAMK1 family","STE protein kinase STE11 family","STE protein kinase STE20 family","Tyrosine protein kinase PDGFR family","Other protein kinase PLK family","Atypical protei
n kinase RIO family","STE protein kinase STE7 family","TKL protein kinase LRRK family","Other protein kinase NAK family","CAMK protein kinase TSSK family","TKL protein kinase STKR family","CAMK protei
n kinase RAD53 family","TKL protein kinase IRAK family","Tyrosine protein kinase Sev family","AGC protein kinase GRK family","Other protein kinase CK2 family","Tyrosine protein kinase Fer family","TKL
 protein kinase MLK family","Tyrosine protein kinase Alk family","CAMK protein kinase DAPK family","Tyrosine protein kinase Ack family","Other protein kinase TTK family","CMGC protein kinase Dyrk1 sub
family","CMGC protein kinase JNK subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase FRAY subfamily","Atypical protein kinase RIO2 subfamily","STE pr
otein kinase TAO subfamily","TKL protein kinase STKR Type 1 subfamily","AGC protein kinase GRK subfamily","TKL protein kinase TAK1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","AGC: Containing
 PKA",PKG,"PKC families","CK1: Casein kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Atypical,"CAMK-unique family","Dual-specificity tyrosine-(Y)-phosphorylation regula
ted kinase (DYRK) family","TK: Tyrosine kinase","Myosin Light Chain Kinase (MLCK) family","Mitogen-activated protein kinases (MAP kinases)","Phosphorylase kinase (PHK) family","CAMK1 family","Protein 
kinase D (PKD) family","RSK family","CLK family","Casein kinase 1 (CK1) family","DCAMKL family","STE20 family","Other protein kinases","RIO family","STE7 family","TKL: Tyrosine kinase-like","Testis sp
ecific kinase (TSSK) family","CAMK-like (CAMKL) family","G protein-coupled receptor kinases (GRKs)","Death-associated kinase (DAPK) family","Dyrk1 subfamily","Non-receptor tyrosine kinases (nRTKs)","J
NK subfamily","RSK subfamily","Receptor tyrosine kinases (RTKs)","HIPK subfamily","STE20 subfamily","FRAY subfamily","Polo-like kinase (PLK) family","RIO2 subfamily","TAO subfamily","Leucine-rich repe
at kinase (LRRK) family","NAK family","CHK1 subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","Opsin/rhodopsin kinases","Casein kinase 2 (CK2) family","Mixed Lineage Kinase (MLK) fam
ily","TTK family","Numb-associated kinase (NAK) family","Other-unique family","Fak family","Janus kinase (JakA) family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XI RTKs: TAM
 (TYRO3-","AXL- and MER-TK) receptor family","Type II RTKs: Insulin receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor fam
ily","Type XVII RTKs: ROS receptors","Fer family","TAK1 subfamily","Ack family"}

> <pathway_reactome>
{"Cell Cycle","Immune System","Signal Transduction",Metabolism,Disease,"Neuronal System","Gene expression (Transcription)","Metabolism of RNA","Developmental Biology","Programmed Cell Death",Hemostasi
s,"Vesicle-mediated transport",Mitotic,"Cytokine Signaling in Immune system","Signaling by Rho GTPases","Innate Immune System","Metabolism of carbohydrates","Disorders of Developmental Biology","Metab
olism of lipids","Transmission across Chemical Synapses","Signaling by Receptor Tyrosine Kinases","Intracellular signaling by second messengers","RNA Polymerase II Transcription","Signaling by GPCR","
rRNA processing","Signaling by Non-Receptor Tyrosine Kinases","Infectious disease","Nervous system development",Apoptosis,"Cell surface interactions at the vascular wall","Membrane Trafficking","Mitot
ic G1 phase and G1/S transition","Signaling by Interleukins","RHO GTPase Effectors","Toll-like Receptor Cascades","Glycogen metabolism","Disorders of Nervous System Development","Sphingolipid metaboli
sm","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by VEGF","Mitotic G2-G2/M phases","PIP3 activates AKT signaling","Generic Transcription Pathway","GPCR downstream signa
lling","Signaling by Insulin receptor","rRNA processing in the nucleus and cytosol","M Phase","Signaling by PTK6","Leishmania infection","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF
1R)","Axon guidance","Caspase activation via extrinsic apoptotic signalling pathway","trans-Golgi Network Vesicle Budding","Signaling by SCF-KIT","G0 and Early G1","Interleukin-2 family signaling","RH
O GTPases activate PAKs","Toll Like Receptor 5 (TLR5) Cascade","Glycogen breakdown (glycogenolysis)","Pervasive developmental disorders","Sphingolipid de novo biosynthesis","G1 Phase","Activation of N
MDA receptors and postsynaptic events","VEGFA-VEGFR2 Pathway","G2/M Transition","Negative regulation of the PI3K/AKT network","Transcriptional Regulation by TP53","G alpha (q) signalling events","Insu
lin receptor signalling cascade","Major pathway of rRNA processing in the nucleolus and cytosol","Mitotic Metaphase and Anaphase","PTK6 promotes HIF1A stabilization","Parasite infection","IGF1R signal
ing cascade","G alpha (i) signalling events","Semaphorin interactions","Toll Like Receptor 4 (TLR4) Cascade","Caspase activation via Dependence Receptors in the absence of ligand","Golgi Associated Ve
sicle Biogenesis","Interleukin-2 signaling","MyD88 cascade initiated on plasma membrane","Loss of function of MECP2 in Rett syndrome","Cyclin D associated events in G1","Post NMDA receptor activation 
events","Centrosome maturation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Regulation of TP53 Activity","Gastrin-CREB signalling pathway via PKC and MAPK","IRS-mediated signalling","Mitotic Ana
phase","Leishmania phagocytosis","IRS-related events triggered by IGF1R","Visual phototransduction","CRMPs in Sema3A signaling","MyD88-independent TLR4 cascade","Interleukin-15 signaling","MAP kinase 
activation","Loss of phosphorylation of MECP2 at T308","Long-term potentiation","Loss of proteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Activity thr
ough Phosphorylation","EGFR Transactivation by Gastrin","PI3K Cascade","Separation of Sister Chromatids","FCGR3A-mediated phagocytosis","Regulation of TP53 Expression and Degradation","The phototransd
uction cascade","TRIF(TICAM1)-mediated TLR4 signaling","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","MAPK targets/ Nuclear events mediated by MAP kinases","Loss o
f Nlp from mitotic centrosomes","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","Regulation of TP53 Degradation","activated TAK1 mediates p38 MAPK activation",In
activation,"recovery and regulation of the phototransduction cascade","TRAF6-mediated induction of TAK1 complex within TLR4 complex","RSK activation","Activation of the AP-1 family of transcription fa
ctors","CREB phosphorylation"}

> <broad_targets>
{ALK,IGF1R,INSR,RPS6KA1}

> <broad_moa>
{"insulin growth factor receptor inhibitor"}

> <synonyms>
{GSK1838705A,1116235-97-2,1116235972,GSK-1838705A,"GSK 1838705A",GSK1838705,"GSK 1838705",cc-268,cc268,MLS006010967,CHEMBL464552,GTPL5683,SCHEMBL2205605,SCHEMBL12428872,BDBM27817,C27H29FN8O3,CHEBI:937
68,AOB5716,DTXSID50648971,EX-A301,EXA301,HMS3656L15,BCP02847,MFCD194,T3079,S2703}

> <pdid>
PD010878

> <targets>
{IGF-1,ALK,IGF-1R}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{25182616}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    1.2948   -3.7516    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -6.5018    3.7420    0.0000 O   0  0
   -7.7993    2.9876    0.0000 C   0  0
   -9.1017    3.7333    0.0000 C   0  0
  -10.3992    2.9790    0.0000 N   0  0
  -11.7021    3.7223    0.0000 C   0  0
  -12.9973    2.9658    0.0000 C   0  0
  -12.9898    1.4658    0.0000 O   0  0
  -11.6870    0.7224    0.0000 C   0  0
  -10.3917    1.4789    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
    3.8933   -3.7570    0.0000 N   0  0
    3.8912   -5.2578    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    5.1895   -7.5109    0.0000 C   0  0
    6.4885   -8.2610    0.0000 C   0  0
    7.7875   -7.5110    0.0000 C   0  0
    7.7876   -6.0110    0.0000 C   0  0
    6.4885   -5.2610    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 17  1  0
 13 23  1  0
 23 24  2  0
 24 10  1  0
  2 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28634

> <plate>
Kinase v5-2

> <well>
N21

> <supplier_cmpd_name>
KX2-391

> <ctcr_id>
700

> <supplier_cmpd_id>
S2700

> <smiles>
O=C(Cc1ccc(cn1)c2ccc(OCCN3CCOCC3)cc2)NCc4ccccc4

> <pd_targets>
{SRC,LYN,ABL1,BCR,TUBB5}

> <pathway_gtopdb>
{Enzyme,"Structural protein",Kinase,"Protein Kinase","TK protein kinase group","Atypical protein kinase group","Tyrosine protein kinase Src family","Atypical protein kinase BCR family"}

> <pathway_chembl>
{Receptors,"Other protein targets","Catalytic receptors",Tubulins,"Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Src family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Cell Cycle","Signaling by Receptor Tyrosine Kinases","Infectious disease",Mitotic,"Signaling by NTRKs","Leishmania infection","Mitotic G2-G2/M phases","Signaling by NTR
K1 (TRKA)","Leishmania parasite growth and survival","G2/M Transition","Signalling to ERKs","Anti-inflammatory response favouring Leishmania parasite infection","Centrosome maturation","Signalling to 
RAS","FCGR3A-mediated IL10 synthesis","Loss of proteins required for interphase microtubule organization from the centrosome","p38MAPK events","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
{SRC}

> <broad_moa>
{"SRC inhibitor","tubulin polymerization inhibitor"}

> <synonyms>
{KX-2-391,KX2391,KX2-391,897016-82-9,897016829,Tirbanibulin,KX-01,KX01,UNII-4V9848RS5G,UNII4V9848RS5G,N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide,Nbenzyl2(5(4(2morpholinoethoxy)
phenyl)pyridin2yl)acetamide,KX-2391,CHEMBL571546,4V9848RS5G,KX2-391;KX-01,KX2391;KX01,2-Pyridineacetamide,2Pyridineacetamide,5-(4-(2-(4-morpholinyl)ethoxy)phenyl)-N-(phe,5(4(2(4morpholinyl)ethoxy)phen
yl)N(phe,T6345,S2700}

> <pdid>
PD003466

> <targets>
{Src}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{23635314}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  1  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7545    0.0000 O   0  0
   -5.2003    1.4932    0.0000 N   0  0
   -6.4990    0.7409    0.0000 C   0  0
   -6.4939   -0.7591    0.0000 C   0  0
   -7.7903   -1.5136    0.0000 C   0  0
   -7.7851   -3.0136    0.0000 Br  0  0
   -9.0919   -0.7681    0.0000 C   0  0
  -10.3884   -1.5226    0.0000 C   0  0
   -9.0971    0.7319    0.0000 C   0  0
   -7.8007    1.4864    0.0000 C   0  0
   -7.8090    2.9872    0.0000 O   0  0
   -9.1125    3.7312    0.0000 C   0  0
   -9.1208    5.2320    0.0000 C   0  0  2  0  0  0
  -10.4224    5.9775    0.0000 C   0  0
  -10.4277    7.4775    0.0000 N   0  0
   -9.1313    8.2321    0.0000 C   0  0
   -7.8297    7.4866    0.0000 C   0  0
   -7.8244    5.9866    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  2  0
 17 10  1  0
 17 18  1  0
 18 19  1  0
 20 19  1  6
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
  5 26  1  0
 26 27  2  0
 27  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28635

> <plate>
Kinase v5-2

> <well>
P03

> <supplier_cmpd_name>
LY2603618 (IC-83)

> <ctcr_id>
7524

> <supplier_cmpd_id>
S2626

> <smiles>
Cc1cnc(NC(=O)Nc2cc(Br)c(C)cc2OC[C@@H]3CNCCO3)cn1

> <pd_targets>
{CHEK1,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","CAMK protein kinase group","Voltage-gated potassium channel","CAMK protein kinase CAMK1 family","CAMK pr
otein kinase CHK1 subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels","Kinases (EC 2.7.x.x)","Voltage-gated ion channels","CAMK: Calcium/calmodulin-dependent protein kinases","Potassium channels","CAMK-like (CAMKL) family","Voltage-gated potassiu
m channels","CHK1 subfamily"}

> <pathway_reactome>
{"DNA Repair","Muscle contraction","DNA Double-Strand Break Repair","Cardiac conduction","Homology Directed Repair","Phase 3 - rapid repolarisation","HDR through Homologous Recombination (HRR) or Sing
le Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Homologous DNA Pairing and Strand Exchange","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{CHEK1}

> <broad_moa>
{"CHK inhibitor"}

> <synonyms>
{Rabusertib,LY2603618,911222-45-2,911222452,"LY 2603618",LY-2603618,IC-83,IC83,UNII-3S9L1NU6U7,UNII3S9L1NU6U7,"ly2603618  IC-83","ly2603618  IC83","Rabusertib (LY2603618)",3S9L1NU6U7,"Rabusertib (USAN
:INN)",LY2603618(IC-83),LY2603618(IC83),"LY2603618 (IC-83)","LY2603618 (IC83)","Rabusertib (USAN/INN)",cc-579,cc579,MLS006011026,SCHEMB,S2626}

> <pdid>
PD010913

> <targets>
{Chk}

> <classes>
{}

> <pubchem_cids>
{11955855}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    1.2934    3.7495    0.0000 C   0  0
    1.2883    5.2495    0.0000 C   0  0
    2.5847    6.0040    0.0000 C   0  0
    3.8863    5.2585    0.0000 C   0  0
    3.8915    3.7585    0.0000 C   0  0
    5.1932    3.0131    0.0000 C   0  0
   -0.0126    5.9981    0.0000 C   0  0
   -1.3103    5.2459    0.0000 O   0  0
   -0.0156    7.4989    0.0000 N   0  0
   -1.3164    8.2475    0.0000 C   0  0
   -1.3217    9.7475    0.0000 C   0  0
   -2.6233   10.4931    0.0000 C   0  0
   -3.9197    9.7386    0.0000 C   0  0
   -3.9146    8.2386    0.0000 C   0  0
   -2.6130    7.4931    0.0000 C   0  0
   -5.2117    7.4838    0.0000 C   0  0
   -6.5138    8.2285    0.0000 F   0  0
   -5.2061    5.9838    0.0000 F   0  0
   -6.5078    6.7287    0.0000 F   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -5.1969    1.4963    0.0000 N   0  0
   -3.8967    0.7484    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 10 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 22 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
  6 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31  2  1  0
 31  5  1  0
 29 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28636

> <plate>
Kinase v5-2

> <well>
P05

> <supplier_cmpd_name>
NVP-BHG712

> <ctcr_id>
6320

> <supplier_cmpd_id>
S2202

> <smiles>
Cn1ncc2c(Nc3cc(ccc3C)C(=O)Nc4cccc(c4)C(F)(F)F)nc(nc12)c5cccnc5

> <pd_targets>
{KDR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","VEGFA-VEGFR2 Pathway","VEGFR2 mediated cell proliferation"}

> <broad_targets>
{EPHB4}

> <broad_moa>
{"ephrin inhibitor"}

> <synonyms>
{NVP-BHG712,NVPBHG712,940310-85-0,940310850,DXH,cc-540,cc540,MLS006011050,NVP-BHG712/,NVPBHG712/,BHG712,SCHEMBL4699731,CHEMBL3752910,C26H20F3N7O,CHEBI:91447,"BHG 712",BHG-712,DTXSID90587779,EX-A160,EX
A160,QCR-258,QCR258,HMS3655D10,HMS3672C11,HMS3747I03,BCP02362,ABP000887,HY-13258A,HY13258A,MFCD20272,T6348,S2202}

> <pdid>
PD010828

> <targets>
{VEGFR,Src,Raf,Bcr-Abl,"Ephrin receptor"}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{16747388}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 30  0  0  0  0            999 V2000
   10.3003    0.3809    0.0000 Cl  0  0
    7.7996   -1.4883    0.0000 C   0  0
    6.4990   -0.7409    0.0000 O   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -6.4842    5.2598    0.0000 C   0  0
   -6.4790    6.7598    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6071   -5.9984    0.0000 O   0  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 19 21  1  0
 21 22  3  0
 13 23  2  0
 23  9  1  0
 23 24  1  0
 24 25  2  0
 25  7  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28637

> <plate>
Kinase v5-2

> <well>
P07

> <supplier_cmpd_name>
OSI-420 (Desmethyl Erlotinib)

> <ctcr_id>
6243

> <supplier_cmpd_id>
S2205

> <smiles>
Cl.COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCO

> <pd_targets>
{EGFR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by GPCR","GPCR downstream signalling","G alpha (q) signalling events","Gastrin-CREB signalling pathway via PKC and MAPK","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{P47342,OSI-420,OSI420,183320-51-6,183320516,"Desmethyl Erlotinib",CP-473420,CP473420,"Desmethyl Erlotinib (hydrochloride)","OSI 420",OSI-420;CP-473420,OSI420;CP473420,"OSI420 HCl",MLS006011273,"OSI-4
20 (cGMP)","OSI420 (cGMP)",SCHEMBL1507689,DTXSID50596524,"OSI-420 (Desmethyl Erlotinib)","OSI420 (Desmethyl Erlotinib)",BCP28007,s2205,CCG-268,CCG268,S2205}

> <pdid>
PD016649

> <targets>
{EGFR}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{18924996}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 31  0  0  0  0            999 V2000
   15.5573  -24.0417    0.0000 C   0  0
   14.2598  -23.2891    0.0000 C   0  0
   14.2619  -21.7882    0.0000 C   0  0
   12.9637  -21.0352    0.0000 C   0  0
   12.9658  -19.5343    0.0000 C   0  0
   11.6676  -18.7813    0.0000 C   0  0
   11.6698  -17.2804    0.0000 C   0  0
   10.3716  -16.5273    0.0000 C   0  0
   10.3737  -15.0265    0.0000 C   0  0
    9.0755  -14.2734    0.0000 C   0  0
    9.0776  -12.7726    0.0000 C   0  0
    7.7794  -12.0195    0.0000 C   0  0
    7.7815  -10.5187    0.0000 C   0  0
    6.4833   -9.7656    0.0000 C   0  0
    6.4855   -8.2648    0.0000 C   0  0
    5.1873   -7.5117    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 O   0  0
    2.5951   -3.0039    0.0000 P   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5923   -4.5039    0.0000 O   0  5
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  3
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2636    2.2496    0.0000 C   0  0
   -2.5801   -0.0303    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 20 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 27 30  1  0
 27 31  1  0
M  CHG  2  22  -1  27   1
M  END
> <name>
UTKinase_V5

> <id>
28638

> <plate>
Kinase v5-2

> <well>
P09

> <supplier_cmpd_name>
Perifosine

> <ctcr_id>
3857

> <supplier_cmpd_id>
S1037

> <smiles>
CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

> <pd_targets>
{AKT1,MAPK14}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","CMGC protein kinase group","AGC protein kinase AKT family","CMGC protein kinase MAPK family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Akt (Protein kinase B","PKB) family","Mitogen-activated protein kinases (MAP k
inases)","p38 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System","RNA Polymerase II Transcription","Innate Immune System","Generic Transcription Pathway","Toll-like Receptor Cascades","Transcriptional Regulation by
 TP53","Toll Like Receptor 5 (TLR5) Cascade","Regulation of TP53 Activity","MyD88 cascade initiated on plasma membrane","Regulation of TP53 Expression and Degradation","MAP kinase activation","Regulat
ion of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Perifosine,157716-52-4,157716524,"157716 52 4","1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate","1,1Dimethylpiperidin1ium4yl octadecyl phosphate","1,1 Dimethylpiperidin 1 ium 4 yl octadecyl pho
sphate",KRX-0401,KRX0401,"KRX 0401",(1,1-dim,1dim,S1037}

> <pdid>
PD012222

> <targets>
{Akt,PI3K}

> <classes>
{}

> <pubchem_cids>
{148177}

$$$$
UTKinase_V5
  SciTegic11012413002D

 43 48  0  0  1  0            999 V2000
    2.4192   -8.3243    0.0000 C   0  0
    1.2028   -7.4466    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.0059   -1.5004    0.0000 C   0  0
   -1.3785   -0.8955    0.0000 O   0  0
    1.2903   -0.7456    0.0000 N   0  0
    2.4080   -1.7447    0.0000 C   0  0
    3.8992   -1.5823    0.0000 C   0  0
    4.7854   -2.7925    0.0000 C   0  0
    4.1805   -4.1651    0.0000 C   0  0
    2.6893   -4.3275    0.0000 C   0  0
    1.8030   -3.1173    0.0000 C   0  0
    5.0672   -5.3760    0.0000 S   0  0
    4.4618   -6.7484    0.0000 O   0  0
    5.9528   -6.5866    0.0000 O   0  0
    6.5593   -5.2145    0.0000 C   0  0
    7.4460   -6.4253    0.0000 C   0  0
    8.9376   -6.2660    0.0000 C   0  0
    9.5453   -4.8947    0.0000 Cl  0  0
    9.8213   -7.4780    0.0000 C   0  0
    9.2136   -8.8494    0.0000 C   0  0
    7.7221   -9.0088    0.0000 C   0  0
    6.8383   -7.7968    0.0000 C   0  0
    5.3468   -7.9562    0.0000 Cl  0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6079   -6.7003    0.0000 C   0  0
   -0.2222   -7.9149    0.0000 C   0  0
   -0.6776   -9.3422    0.0000 C   0  0
   -2.1432   -9.6615    0.0000 O   0  0
    0.3320  -10.4528    0.0000 N   0  0
    1.8079  -10.2697    0.0000 C   0  0
    2.4273  -11.6359    0.0000 C   0  0
    1.3194  -12.6471    0.0000 C   0  0
    0.0153  -11.9060    0.0000 C   0  0  2  0  0  0
   -1.3526  -12.5170    0.0000 C   0  0
   -1.5087  -14.0096    0.0000 N   0  0
   -2.8035  -14.7413    0.0000 C   0  0
   -2.4879  -16.2077    0.0000 C   0  0
   -0.9957  -16.3606    0.0000 C   0  0
   -0.3891  -14.9887    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
 13 16  1  0
 16 17  2  0
 16 18  2  0
 16 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 20  1  0
 26 27  1  0
  4 28  2  0
 28 29  1  0
 28 30  1  0
 30  2  2  0
 30 31  1  0
 31 32  2  0
 31 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 33  1  0
 37 38  1  6
 38 39  1  0
 39 40  1  0
 40 41  1  0
 41 42  1  0
 42 43  1  0
 43 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28639

> <plate>
Kinase v5-2

> <well>
P11

> <supplier_cmpd_name>
PHA-665752

> <ctcr_id>
7744

> <supplier_cmpd_id>
S1070

> <smiles>
Cc1[nH]c(\C=C/2\C(=O)Nc3ccc(cc23)S(=O)(=O)Cc4c(Cl)cccc4Cl)c(C)c1C(=O)N5CCC[C@@H]5CN6CCCC6

> <pd_targets>
{CLK3,HIPK2,NUAK2,DCLK3,MAP2K5,MET,SRC,CLK1,NTRK3,CDK4,DDR1,PAK1,TYK2,CAMK1,CASK,PRPF4B,FLT3,MST1R,KDR,ABL1,KIT,STK10,CDK16,CAMKK2,CDK14,INSRR,BMP2K,PAK5,HIPK1,GAK,YES1,RPS6KA6,MYLK,CDK15,MAP4K4,EIF2A
K4,BMPR2,CDK7,PDGFRB,GRK1,MAP4K3,RIPK1,RPS6KA3,DCLK1,ROCK2,NTRK1,MAP4K1,PIP5K1A,CSNK2A2,JAK1,NEK2,PIP4K2B,FGFR1,FGFR3,INSR,AURKC,DDR2,STK3,MAP4K5,HUNK,SLK,RET,NIM1K,CAMK2G,MAK,PRKAA2,TBK1,NUAK1,TNIK,M
AP3K19,CAMKK1,MYLK2,CSNK1D,GRK7,HIPK4,MAP3K7,CAMK2A,PTK2B,CSNK1E,MAP3K3,CDK18,ULK1,STK17B,ABL2,PHKG2,MAPK7,MAP2K1,RIOK3,CDKL2,RPS6KA5,CSF1R,NTRK2,PHKG1,PLK2,CILK1,TAOK3,TAOK1,MAP2K2,AURKB,JAK3,TEK,CDK
9,AXL,BLK,PAK3,ROS1,ALK,EPHB6,STK17A,MAP3K4,PDGFRA,IRAK3,IKBKE,SRPK3,ULK2,IRAK4,EPHA8,RIOK1,TSSK1B,SRPK2,STK16,STK11,TYRO3,MAP3K2,PLK4,MARK2,FGFR2,STK33,PTK2,MINK1,DCLK2,IRAK1,FLT4,RPS6KB1,CLK2,MAP3K1
3,JAK2,FGR,SRPK1,MAP4K2,EGFR,MERTK,CAMK2D,PRKAA1,CDK17,LCK,TIE1,HIPK3,MAP3K12,AAK1,SIK2,TAOK2,STK26,CAMK1D,GRK4}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,"Protein Kinase","CMGC protein kinase group","CAMK protein kinase group","STE protein kinase group","TK protein kinase group","Other protein kinase group","AGC pr
otein kinase group","TKL protein kinase group","CK1 protein kinase group","Atypical protein kinase group","CMGC protein kinase CLK family","CMGC protein kinase DYRK family","CAMK protein kinase CAMK1 
family","CAMK protein kinase DCAMK1 family","STE protein kinase STE7 family","Tyrosine protein kinase Met family","Tyrosine protein kinase Src family","Tyrosine protein kinase Trk family","Tyrosine pr
otein kinase DDR family","STE protein kinase STE20 family","Tyrosine protein kinase JakA family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase 
Abl family","CMGC protein kinase CDK family","Other protein kinase CAMKK family","Tyrosine protein kinase InsR family","Other protein kinase NAK family","AGC protein kinase RSK family","CAMK protein k
inase MLCK family","Other protein kinase PEK family","TKL protein kinase STKR family","AGC protein kinase GRK family","TKL protein kinase RIPK family","AGC protein kinase DMPK family","Other protein k
inase CK2 family","Other protein kinase NEK family","Tyrosine protein kinase FGFR family","Other protein kinase AUR family","Tyrosine protein kinase Ret family","CAMK protein kinase CAMK2 family","CMG
C protein kinase RCK family","Other protein kinase IKK family","STE protein kinase STE11 family","CK1 protein kinase CK1 family","TKL protein kinase MLK family","Tyrosine protein kinase Fak family","O
ther protein kinase ULK family","CAMK protein kinase DAPK family","CAMK protein kinase PHk family","CMGC protein kinase MAPK family","Atypical protein kinase RIO family","CMGC protein kinase CDKL fami
ly","Other protein kinase PLK family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Sev family","TKL protein kinase IRAK family","CMGC protein kina
se SRPK family","Tyrosine protein kinase Eph family","CAMK protein kinase TSSK family","CAMK protein kinase unique family","Tyrosine protein kinase EGFR family","CMGC protein kinase HIPK subfamily","C
AMK protein kinase NuaK subfamily","STE protein kinase PAKA subfamily","STE protein kinase SLK subfamily","CMGC protein kinase TAIRE subfamily","Other protein kinase Meta subfamily","CMGC protein kina
se PFTAIRE","STE protein kinase PAKB subfamily","AGC protein kinase RSK subfamily","STE protein kinase MSN subfamily","Other protein kinase GCN2 subfamily","TKL protein kinase STKR Type 2 subfamily","
CMGC protein kinase CDK7 subfamily","AGC protein kinase GRK subfamily","STE protein kinase KHS subfamily","AGC protein kinase ROCK subfamily","STE protein kinase MST subfamily","CAMK protein kinase NI
M1 subfamily","CMGC protein kinase MAK","CAMK protein kinase AMPK subfamily","TKL protein kinase TAK1 subfamily","STE protein kinase MEKK2","CMGC protein kinase PCTAIRE","CMGC protein kinase ERK5","At
ypical protein kinase RIO3 subfamily","AGC protein kinase MSK subfamily","Other protein kinase PLK2","STE protein kinase TAO subfamily","CMGC protein kinase CDK9 subfamily","TKL protein kinase STKR Ty
pe 1 subfamily","Atypical protein kinase RIO1 subfamily","CAMK protein kinase LKB subfamily","CAMK protein kinase MARK subfamily","AGC protein kinase p70 subfamily","TKL protein kinase LZK subfamily",
"CAMK protein kinase QIK subfamily","STE protein kinase YSK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7",
"Sterile 11","Sterile 20 kinases","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","Lipid modifying kinases","CK1: Casein kinase 1",Atypical,"CLK family","Dual-specificity tyrosine-(Y)-phos
phorylation regulated kinase (DYRK) family","CAMK-like (CAMKL) family","DCAMKL family","STE7 family","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","STE20 family","CAMK1 family","CASK fa
mily","Other protein kinases","RSK family","Myosin Light Chain Kinase (MLCK) family","TKL: Tyrosine kinase-like","G protein-coupled receptor kinases (GRKs)","DMPK family","Type I PIP kinases (1-phosph
atidylinositol-4-phosphate 5-kinase family)","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","CAMK2 family","RCK family","Casein kinase 1 (CK1) family","STE11 family","Death
-associated kinase (DAPK) family","Phosphorylase kinase (PHK) family","Mitogen-activated protein kinases (MAP kinases)","RIO family","Cyclin-dependent kinase-like (CDKL) family","SRPK family","Testis 
specific kinase (TSSK) family","CAMK-unique family","HIPK subfamily","NuaK subfamily","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","CDK4 subfamily","PAKA subfamily","PRP4
 subfamily","SLK subfamily","TAIRE subfamily","CAMKK family","Numb-associated kinase (NAK) family","PAKB subfamily","RSK subfamily","MSN subfamily","PEK family","Receptor serine/threonine kinase (RSTK
) family","CDK7 subfamily","Opsin/rhodopsin kinases","KHS subfamily","Receptor interacting protein kinase (RIPK) family","Rho kinase","Casein kinase 2 (CK2) family","NIMA (never in mitosis gene a)- re
lated kinase (NEK) family","Aurora kinase (Aur) family","MST subfamily","HUNK subfamily","NIM1 subfamily","AMPK subfamily","IKK family","STE20 subfamily","Mixed Lineage Kinase (MLK) family","Unc-51-li
ke kinase (ULK) family","ERK subfamily","RIO3 subfamily","MSK subfamily","Polo-like kinase (PLK) family","TAO subfamily","CDK9 subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","RIO1
 subfamily","NAK family","LKB subfamily","MARK subfamily","p70 subfamily","QIK subfamily","YSK subfamily","GRK4 subfamily","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Src family","T
ype VII RTKs: Neurotrophin receptor/Trk family","Type XVI RTKs: DDR (collagen receptor) family","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF 
(vascular endothelial growth factor) receptor family","Abl family","Meta subfamily","Type II RTKs: Insulin receptor family","GCN2 subfamily","Type II receptor serine/threonine kinases","Type V RTKs: F
GF (fibroblast growth factor) receptor family","Type XIV RTKs: RET","TAK1 subfamily","Fak family","Type XII RTKs: TIE family of angiopoietin receptors","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) re
ceptor family","Type XVII RTKs: ROS receptors","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XIII RTKs: Ephrin receptor family","LZK subfamily","Type I RTKs: ErbB (epidermal g
rowth factor) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Developmental Biology","Cell Cycle","Extracellular matrix organization","Immune System","Neuronal System",Disease,"Vesicle-mediated transport"
,"Cellular responses to external stimuli",Metabolism,Autophagy,"Metabolism of RNA",Hemostasis,"Programmed Cell Death","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Nervou
s system development",Mitotic,"Non-integrin membrane-ECM interactions","Cytokine Signaling in Immune system","Transmission across Chemical Synapses","Infectious disease","Diseases of signal transducti
on by growth factor receptors and second messengers","Innate Immune System","Membrane Trafficking","Signaling by Rho GTPases","Cellular responses to stress","Signaling by TGFB family members","Intrace
llular signaling by second messengers","Signaling by GPCR","Metabolism of lipids","Signaling by Hippo",Macroautophagy,"Metabolism of carbohydrates","rRNA processing","MAPK family signaling cascades","
MTOR signalling","Cell surface interactions at the vascular wall",Apoptosis,"Generic Transcription Pathway","Signaling by NTRKs","Axon guidance","Mitotic G1 phase and G1/S transition","Interferon Sign
aling","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by Insulin receptor","Signaling by MST1","Signaling by VEGF","Leishmania infection","Signaling by KIT in disease","N
eutrophil degranulation","trans-Golgi Network Vesicle Budding","RHO GTPase Effectors","Cellular Senescence","Response of EIF2AK4 (GCN2) to amino acid deficiency","Signaling by BMP","HIV Infection","PI
P3 activates AKT signaling","GPCR downstream signalling","Toll-like Receptor Cascades","Phospholipid metabolism","Regulation of mitotic cell cycle","Signaling by FGFR in disease","Mitotic G2-G2/M phas
es","Signaling by Interleukins","Selective autophagy","Glycogen metabolism","rRNA processing in the nucleus and cytosol","M Phase","MAPK1/MAPK3 signaling","Signaling by PDGFR in disease","mTORC1-media
ted signalling","Clathrin-mediated endocytosis","Apoptotic execution phase","Transcriptional Regulation by TP53","Signaling by NTRK1 (TRKA)","Semaphorin interactions","Signaling by NTRK3 (TRKC)","G1 P
hase","EPH-Ephrin signaling","Interferon alpha/beta signaling","Activation of NMDA receptors and postsynaptic events","Insulin receptor signalling cascade","VEGFA-VEGFR2 Pathway","Parasite infection",
"Drug resistance of KIT mutants","Signaling by ROBO receptors","Golgi Associated Vesicle Biogenesis","Leishmania parasite growth and survival","RHO GTPases activate PAKs","Oxidative Stress Induced Sen
escence","HIV Life Cycle","Negative regulation of the PI3K/AKT network","G alpha (i) signalling events","Toll Like Receptor 4 (TLR4) Cascade","Toll Like Receptor 5 (TLR5) Cascade","PI Metabolism","Ant
iviral mechanism by IFN-stimulated genes","APC/C-mediated degradation of cell cycle proteins","Signaling by FGFR1 in disease","Signaling by FGFR3 in disease","RET signaling","G2/M Transition","Interle
ukin-2 family signaling","Interleukin-1 family signaling",Mitophagy,"Glycogen breakdown (glycogenolysis)","Major pathway of rRNA processing in the nucleolus and cytosol","Transcriptional Regulation by
 VENTX","Mitotic Metaphase and Anaphase","RAF/MAP kinase cascade","Transcriptional regulation by RUNX1","Drug resistance of PDGFR mutants","Toll Like Receptor 2 (TLR2) Cascade","Signaling by FGFR2 in 
disease","VEGF ligand-receptor interactions","G alpha (q) signalling events","Host Interactions of HIV factors","Cargo recognition for clathrin-mediated endocytosis","Apoptotic cleavage of cellular pr
oteins","Regulation of TP53 Activity","Signalling to ERK5","Sema4D in semaphorin signaling","Signalling to ERKs","Activated NTRK3 signals through PI3K","Cyclin D associated events in G1","EPHB-mediate
d forward signaling","Regulation of IFNA signaling","Post NMDA receptor activation events","Assembly and cell surface presentation of NMDA receptors","IRS-mediated signalling","VEGFR2 mediated cell pr
oliferation","Leishmania phagocytosis","Dasatinib-resistant KIT mutants","Activation of RAC1","Anti-inflammatory response favouring Leishmania parasite infection","Late Phase of HIV Life Cycle",PI5P,"
PP2A and IER3 Regulate PI3K/AKT Signaling","Visual phototransduction","MyD88-independent TLR4 cascade","MyD88 cascade initiated on plasma membrane","Synthesis of PIPs at the plasma membrane","ISG15 an
tiviral mechanism","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","FGFR1 mutant receptor activation","Signaling by FGFR3 point mutants in cancer","Centrosome maturation
","Interleukin-2 signaling","Interleukin-1 signaling","Receptor Mediated Mitophagy","Role of ABL in ROBO-SLIT signaling","Activation of TRKA receptors","Mitotic Anaphase","Interleukin-15 signaling","R
UNX1 regulates transcription of genes involved in BCR signaling","Ephrin signaling","Imatinib-resistant PDGFR mutants","Toll Like Receptor TLR6:TLR2 Cascade","EPHA-mediated growth cone collapse","FGFR
2 mutant receptor activation","VEGF binds to VEGFR leading to receptor dimerization","Gastrin-CREB signalling pathway via PKC and MAPK","The role of Nef in HIV-1 replication and disease pathogenesis",
"Regulation of TP53 Activity through Phosphorylation","Sema4D mediated inhibition of cell attachment and migration","Signalling to RAS","Activation of RAC1 downstream of NMDARs","PI3K Cascade","FCGR3A
-mediated phagocytosis","Activation of AMPK downstream of NMDARs","FCGR3A-mediated IL10 synthesis","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Transcription of 
the HIV genome","The phototransduction cascade","TRIF(TICAM1)-mediated TLR4 signaling","MAP kinase activation","Sema4D induced cell migration and growth-cone collapse","Prolonged ERK activation events
","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Acetylation","Signaling by activated point mutants of FGFR1","FGFR3 mutant receptor activation","Loss of p
roteins required for interphase microtubule organization from the centrosome","NGF-independant TRKA activation","CD163 mediating an anti-inflammatory response","Separation of Sister Chromatids","MyD88
:MAL(TIRAP) cascade initiated on plasma membrane","Activated point mutants of FGFR2","EGFR Transactivation by Gastrin","Nef-mediates down modulation of cell surface receptors by recruiting them to cla
thrin adapters","p38MAPK events","RSK activation","HIV Transcription Elongation",Inactivation,"recovery and regulation of the phototransduction cascade","IKK complex recruitment mediated by RIP1","MAP
K targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","PI5P Regulates 
TP53 Acetylation","Signaling by activated point mutants of FGFR3","Ras activation upon Ca2+ influx through NMDA receptor","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Loss of Nlp from mitot
ic centrosomes","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Frs2-mediated activation","activated TAK1 mediates p38 MAPK activation","Nef Mediated CD4 Down-regulation","Tat-mediated
 elongation of the HIV-1 transcript","CREB phosphorylation","APC-Cdc20 mediated degradation of Nek2A","ERK/MAPK targets","Formation of HIV-1 elongation complex containing HIV-1 Tat","ERKs are inactiva
ted"}

> <broad_targets>
{MET}

> <broad_moa>
{"c-Met inhibitor"}

> <synonyms>
{SCHEMBL93657,CHEBI:91394,ZINC33359844,S1070,PHA-665752}

> <pdid>
PD013025

> <targets>
{c-Met}

> <classes>
{}

> <pubchem_cids>
{87065666}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 28  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 N   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.6929   -4.0817    0.0000 C   0  0
    0.3385   -5.5341    0.0000 C   0  0
    1.4233   -6.5700    0.0000 N   0  0
    2.8629   -6.1484    0.0000 C   0  0
    4.1386   -6.9360    0.0000 N   0  0
    5.2822   -5.9653    0.0000 C   0  0
    4.7125   -4.5777    0.0000 C   0  0
    3.2176   -4.6910    0.0000 C   0  0
    2.1327   -3.6551    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.8813   -1.4408    0.0000 C   0  0
   -4.5721   -0.1292    0.0000 C   0  0
   -6.0471   -0.4022    0.0000 C   0  0
   -6.2433   -1.8893    0.0000 C   0  0
   -4.8896   -2.5354    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 13  1  0
 17 18  2  0
 18 10  1  0
  9 19  1  0
 19  2  1  0
 19  6  2  0
  7 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28640

> <plate>
Kinase v5-2

> <well>
P13

> <supplier_cmpd_name>
PP-121

> <ctcr_id>
6342

> <supplier_cmpd_id>
S2622

> <smiles>
Nc1ncnc2n(nc(c3cnc4[nH]ccc4c3)c12)C5CCCC5

> <pd_targets>
{CSF1R,PIK3CD,PDGFRA,PIK3CB,ABL1,EPHB4,MARK3,JAK2,PAK4,PRKACA,PRKD3,BCR,DAPK3,MTOR,HCK,KDR,LTK,MAP2K2,MAPK14,ROCK2,FYN,LCK,MAP4K2,MST1R,PI4KB,PIK3CG,MAPK8,PIK3CA,EGFR,LIMK1,CDK5,ACVR1,CLK4,ATR,PDGFRB,
PRKDC,SRC,FLT1,GSK3A,MAP4K4,MAP4K5,ROCK1,IKBKE,ALK,IGF1R,MAP2K1,TYRO3,LRRK2,RET,BTK,TNK2,PTK2,PRKCQ,PRKAA1,FGFR1,CLK2,CSNK1A1,TAOK1,MAPK9,CDK8}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","TK protein kinase group","CAMK protein kinase group","STE protein kinase group","AGC protein kinase group","Atypical protein kinase group","CMGC protein ki
nase group","TKL protein kinase group","Other protein kinase group","CK1 protein kinase group","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Eph 
family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase JakA family","STE protein kinase STE20 family","AGC protein kinase PKA family","CAMK protein kinase PKD family","Atypical protein ki
nase BCR family","CAMK protein kinase DAPK family","Atypical protein kinase PIKK family","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Alk family
","STE protein kinase STE7 family","CMGC protein kinase MAPK family","AGC protein kinase DMPK family","Tyrosine protein kinase Met family","Tyrosine protein kinase EGFR family","TKL protein kinase LIS
K family","CMGC protein kinase CDK family","TKL protein kinase STKR family","CMGC protein kinase CLK family","CMGC protein kinase GSK family","Tyrosine protein kinase InsR family","Tyrosine protein ki
nase Axl family","TKL protein kinase LRRK family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Ack family","Tyrosine protein kinase Fak family","A
GC protein kinase PKC family","Tyrosine protein kinase FGFR family","CK1 protein kinase CK1 family","CAMK protein kinase MARK subfamily","STE protein kinase PAKB subfamily","Atypical protein kinase FR
AP subfamily","CMGC protein kinase p38 subfamily","AGC protein kinase ROCK subfamily","Tyrosine protein kinase SrcA","STE protein kinase KHS subfamily","CMGC protein kinase JNK subfamily","TKL protein
 kinase LIMK subfamily","CMGC protein kinase CDK5 subfamily","TKL protein kinase STKR1","STE protein kinase MSN subfamily","TKL protein kinase STKR Type 1 subfamily","AGC protein kinase PKC delta subf
amily","CAMK protein kinase AMPK subfamily","STE protein kinase TAO subfamily","CMGC protein kinase CDK8 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","Lipid modifying kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","St
erile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families",Atypical,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","TK: Tyrosine kinase",Phosphatidylinositol-4,"5-
bisphosphate 3-kinase family","CAMK-like (CAMKL) family","STE20 family","Protein kinase A (PKA) family","Protein kinase D (PKD) family","Death-associated kinase (DAPK) family","Phosphatidyl inositol 3
' kinase-related kinases (PIKK) family","STE7 family","Mitogen-activated protein kinases (MAP kinases)","DMPK family","1-phosphatidylinositol 4-kinase family","TKL: Tyrosine kinase-like","Cyclin-depen
dent kinase (CDK) family","CLK family","Glycogen synthase kinase (GSK) family","Other protein kinases","Protein kinase C (PKC) family","Casein kinase 1 (CK1) family","Receptor tyrosine kinases (RTKs)"
,"Non-receptor tyrosine kinases (nRTKs)","MARK subfamily","PAKB subfamily","FRAP subfamily","p38 subfamily","Rho kinase","KHS subfamily","JNK subfamily","LIM domain kinase (LISK) family","CDK5 subfami
ly","Receptor serine/threonine kinase (RSTK) family","ATR subfamily","Other PIKK family kinases","GSK subfamily","MSN subfamily","IKK family","Leucine-rich repeat kinase (LRRK) family","Delta subfamil
y","AMPK subfamily","TAO subfamily","CDK8 subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Abl family","Type XIII RTKs: Ephrin receptor family","Janus kinase (JakA) family","Src fami
ly","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor fam
ily","Type I RTKs: ErbB (epidermal growth factor) receptor family","LIMK subfamily","Type I receptor serine/threonine kinases","Type II RTKs: Insulin receptor family","Type XI RTKs: TAM (TYRO3-","AXL-
 and MER-TK) receptor family","Type XIV RTKs: RET","Tec family","Ack family","Fak family","Type V RTKs: FGF (fibroblast growth factor) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System",Disease,"Signal Transduction","Developmental Biology","Cell Cycle",Metabolism,"Programmed Cell Death","DNA Repair","Cellular responses to external st
imuli","RNA Polymerase II Transcription","Cytokine Signaling in Immune system","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinase
s","Infectious disease","Nervous system development",Mitotic,"Metabolism of lipids",Apoptosis,"Innate Immune System","Signaling by GPCR","DNA Double-Strand Break Repair","Intracellular signaling by se
cond messengers","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases","Generic Transcription Pathway","Signaling by Interleukins","Signaling by PDGFR in disease","Signaling by I
nsulin receptor","Leishmania infection","Axon guidance","Oncogenic MAPK signaling","Mitotic G1 phase and G1/S transition","Mitotic G2-G2/M phases","Sphingolipid metabolism","Caspase activation via ext
rinsic apoptotic signalling pathway","HIV Infection","Signaling by VEGF","Signaling by NTRKs","Toll-like Receptor Cascades","Signaling by MST1","Phospholipid metabolism","Signaling by FGFR in disease"
,"GPCR downstream signalling","Homology Directed Repair","PIP3 activates AKT signaling","Cytosolic sensors of pathogen-associated DNA","SARS-CoV Infections","Cellular Senescence","Signaling by Type 1 
Insulin-like Growth Factor 1 Receptor (IGF1R)","Signaling by PTK6","Signaling by WNT in cancer","M Phase","Signaling by NOTCH1 in Cancer","Transcriptional Regulation by VENTX",Interleukin-3,"Interleuk
in-5 and GM-CSF signaling","Drug resistance of PDGFR mutants","Insulin receptor signalling cascade","Parasite infection","EPH-Ephrin signaling","Signaling by RAS mutants","G1 Phase","Signaling by ROBO
 receptors","G2/M Transition","Sphingolipid de novo biosynthesis","Caspase activation via Dependence Receptors in the absence of ligand","Transcriptional Regulation by TP53","Host Interactions of HIV 
factors","VEGFA-VEGFR2 Pathway","Signaling by NTRK1 (TRKA)","Toll Like Receptor 5 (TLR5) Cascade","Semaphorin interactions","PI Metabolism","Signaling by FGFR1 in disease","G alpha (q) signalling even
ts","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Negative regulation of the PI3K/AKT network","STING mediated induction of host immune responses","VEGF ligand-recepto
r interactions","SARS-CoV-1 Infection","Oxidative Stress Induced Senescence","Toll Like Receptor 4 (TLR4) Cascade","IGF1R signaling cascade","PTK6 promotes HIF1A stabilization","RET signaling","G alph
a (i) signalling events","Signaling by AMER1 mutants","Mitotic Metaphase and Anaphase","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Interleukin receptor SHC signaling","Imatinib-resistant P
DGFR mutants","IRS-mediated signalling","Leishmania phagocytosis","EPHB-mediated forward signaling","Signaling downstream of RAS mutants","Cyclin D associated events in G1","Activation of RAC1","Centr
osome maturation","Regulation of TP53 Activity","The role of Nef in HIV-1 replication and disease pathogenesis","VEGFR2 mediated cell proliferation","Signalling to ERKs","MyD88 cascade initiated on pl
asma membrane","Sema4D in semaphorin signaling","Synthesis of PIPs at the Golgi membrane","Synthesis of PIPs at the plasma membrane","FGFR1 mutant receptor activation","Gastrin-CREB signalling pathway
 via PKC and MAPK","HDR through Homologous Recombination (HRR)",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","IRF3-mediated induction of type I IFN","VEGF binds to VEGFR leading to receptor dimeri
zation","SARS-CoV-1 Genome Replication and Transcription","MyD88-independent TLR4 cascade","IRS-related events triggered by IGF1R","Visual phototransduction","Truncations of AMER1 destabilize the dest
ruction complex","Mitotic Anaphase","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","PI3K Cascade","FCGR3A-mediated phagocytosis","Loss of proteins required for interphase microtubule organi
zation from the centrosome","Regulation of TP53 Expression and Degradation","Nef and signal transduction","Prolonged ERK activation events","MAP kinase activation","Sema4D induced cell migration and g
rowth-cone collapse","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Signaling by cytosolic FGFR1 fusion mutants","EGFR Transactivation by Gastrin","R
egulation of TP53 Activity through Phosphorylation","Homologous DNA Pairing and Strand Exchange","Signalling to RAS","Replication of the SARS-CoV-1 genome","TRIF(TICAM1)-mediated TLR4 signaling","The 
phototransduction cascade","Signaling by activated point mutants of FGFR1","Separation of Sister Chromatids","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","Frs2-mediated acti
vation","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","Presynaptic phase of homologous DNA pairing and strand exchange","p38MAPK events","Activation of IRF3
/IRF7 mediated by TBK1/IKK epsilon",Inactivation,"recovery and regulation of the phototransduction cascade","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{ABL1,EGFR,HCK,KDR,MTOR,PDGFRA,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC,SRC}

> <broad_moa>
{"protein tyrosine kinase inhibitor"}

> <synonyms>
{PP121,1092788-83-4,1092788834,PP-121,"PP 121",CHEMBL1081312,UNII-5B9VB06146,UNII5B9VB06146,CHEBI:50915,5B9VB06146,KS1,Kinome_2001,Kinome2001,Kinome-2001,"Kinome 2001",B2172,cc-496,cc496,MLS006010957,
pp121/pp-121,pp121/pp121,GTPL8013,SCHEMBL12265009,AOB4424,DTXSID00648002,HMS3656D05,BCP02256,C17H17N7,EX-A2139,EXA2139,ABP000938,BDBM503136,T2415,S2622,Pp121}

> <pdid>
PD005215

> <targets>
{DNA-PK,mTOR,PDGF,"PI3K AND TKI",Apoptosis,PDGFR,Src,VEGFR}

> <classes>
{Apoptosis,PI3K/Akt/mTOR,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{24905142}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 41  0  0  0  0            999 V2000
    0.1711  -10.9062    0.0000 C   0  0
   -1.2966  -10.5966    0.0000 C   0  0
   -0.8307  -12.0224    0.0000 C   0  0
   -2.2982  -11.7132    0.0000 O   0  0
   -1.7622   -9.1698    0.0000 C   0  0
   -0.7600   -8.0526    0.0000 C   0  0
    0.7077   -8.3622    0.0000 O   0  0
   -1.2256   -6.6258    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 N   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -5.2007   -1.4909    0.0000 C   0  0
   -6.4972   -0.7365    0.0000 C   0  0
   -6.4920    0.7635    0.0000 C   0  0
   -7.7907    1.5158    0.0000 O   0  0
   -9.0920    0.7680    0.0000 C   0  0
  -10.3911    1.5179    0.0000 C   0  0
  -11.6901    0.7679    0.0000 C   0  0
  -11.6901   -0.7321    0.0000 C   0  0
  -10.3911   -1.4821    0.0000 C   0  0
   -9.0920   -0.7321    0.0000 C   0  0
  -10.3911   -2.9829    0.0000 C   0  0
  -11.6896   -3.7337    0.0000 F   0  0
   -9.0918   -3.7325    0.0000 F   0  0
  -10.3903   -4.4829    0.0000 F   0  0
   -5.1903    1.5090    0.0000 C   0  0
   -5.1852    3.0090    0.0000 Cl  0  0
   -3.8939    0.7546    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 29 31  1  0
 31 32  1  0
 31 33  1  0
 31 34  1  0
 23 35  1  0
 35 36  1  0
 35 37  2  0
 37 20  1  0
 18 38  2  0
 38 11  1  0
 38 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28641

> <plate>
Kinase v5-2

> <well>
P15

> <supplier_cmpd_name>
TAK-285

> <ctcr_id>
6326

> <supplier_cmpd_id>
S2784

> <smiles>
CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12

> <pd_targets>
{ERBB4,ERBB2,EGFR,LYN,MET,MAP2K1,LCK,ERBB3,MAP2K5,CSK,AURKB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","STE protein kinase group","Other protein kinase group","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Src family","Tyrosine p
rotein kinase Met family","STE protein kinase STE7 family","Tyrosine protein kinase Csk family","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","STE7 family","Other prote
in kinases","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Aurora kinase (Aur) family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Src family","Type X R
TKs: HGF (hepatocyte growth factor) receptor family","Csk family"}

> <pathway_reactome>
{"Neuronal System","Developmental Biology","Signal Transduction",Disease,"Cell Cycle","Transmission across Chemical Synapses","Nervous system development","Signaling by GPCR","Infectious disease","Sig
naling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Neurotransmitter receptors and postsynaptic signal transmission","Axon 
guidance","GPCR downstream signalling","Leishmania infection","Signaling by NTRKs","HIV Infection","Oncogenic MAPK signaling","M Phase","Activation of NMDA receptors and postsynaptic events","Semaphor
in interactions","G alpha (q) signalling events","Leishmania parasite growth and survival","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Signaling by RAS mutants","Mitotic Metaphase 
and Anaphase","Post NMDA receptor activation events","Sema4D in semaphorin signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Anti-inflammatory response favouring Leishmania parasite infec
tion","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis","Signalling to ERK5","Signaling downstream of RAS mutants","Mitotic Anaphase","Long-term potentiation","Sema4
D induced cell migration and growth-cone collapse","EGFR Transactivation by Gastrin","FCGR3A-mediated IL10 synthesis","Sema4D mediated inhibition of cell attachment and migration","Prolonged ERK activ
ation events","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Separation of Sister Chromatids","Frs2-mediated activation","Nef Mediated CD4 Down-regul
ation"}

> <broad_targets>
{ERBB2}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{AK28,TAK-285,TAK285,871026-44-7,871026447,"TAK 285",UNII-70CCB438L6,UNII70CCB438L6,CHEMBL1614725,70CCB438L6,C26H25ClF3N5O3,3poz,3rcd,03P,3w2o,cc-290,cc290,MLS006011276,SCHEMBL982278,DTXSID10236136,EX
-A088,EXA088,SYN1153,TAK285/TAK-285,TAK285/TAK285,HMS3656J08,HMS3750E17,BCP04168,2741AH,BDBM50358430,MFCD,S2784}

> <pdid>
PD010574

> <targets>
{EGFR,HER2}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{11620908}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    4.8089   -4.6669    0.0000 O   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2566    0.5871    0.0000 O   0  0
    4.9531   -1.9978    0.0000 N   0  0
    6.4437   -1.8466    0.0000 C   0  0
    7.3222   -3.0635    0.0000 C   0  0
    8.8147   -2.9143    0.0000 C   0  0
    9.6903   -4.1323    0.0000 C   0  0
    9.0732   -5.4995    0.0000 C   0  0
    7.5807   -5.6488    0.0000 C   0  0
    6.7052   -4.4308    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
  4 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 15  1  0
 24 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28642

> <plate>
Kinase v5-2

> <well>
P17

> <supplier_cmpd_name>
Tideglusib

> <ctcr_id>
2398

> <supplier_cmpd_id>
S2823

> <smiles>
O=C1SN(C(=O)N1Cc2ccccc2)c3cccc4ccccc34

> <pd_targets>
{GSK3B,REP}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase GSK family"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Kinases (EC 2.7.x.x)","Anti-infective targets","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Viral protein targets","Glycogen synthase kinase (GSK) family","Corona
virus (CoV) proteins","GSK subfamily"}

> <pathway_reactome>
{Disease,"Infectious disease","SARS-CoV Infections","SARS-CoV-1 Infection","SARS-CoV-2 Infection","SARS-CoV-1 Genome Replication and Transcription","SARS-CoV-2 Genome Replication and Transcription","R
eplication of the SARS-CoV-1 genome","Replication of the SARS-CoV-2 genome"}

> <broad_targets>
{GSK3B}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{Tideglusib(NP-031112),Tideglusib(NP031112),Tideglusib,865854-05-3,865854053,NP031112,NP-12,NP12,"4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione","4Benzyl2(naphthalen1yl)1,2,4thiadiazoli
dine3,5dione",UNII-Q747Y6TT42,UNIIQ747Y6TT42,"NP 031112",NP-031112,Q747Y6TT42,"1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-","1,2,4Thiadiazolidine3,5dione, 2(1naphthalenyl)4(p
henylmethyl)",T3067,S2823}

> <pdid>
PD012719

> <targets>
{GSK-3}

> <classes>
{PI3K/Akt/mTOR,Stem Cell/Wnt}

> <pubchem_cids>
{11313622}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    7.0503  -11.0244    0.0000 C   0  0
    5.5827  -10.7143    0.0000 C   0  0
    5.1163   -9.2878    0.0000 C   0  0
    3.6479   -8.9775    0.0000 S   0  0
    2.6459  -10.0938    0.0000 O   0  0
    4.1134  -10.4035    0.0000 O   0  0
    3.1815   -7.5510    0.0000 N   0  0
    1.7131   -7.2408    0.0000 C   0  0
    0.7130   -8.3588    0.0000 C   0  0
   -0.7552   -8.0517    0.0000 C   0  0
   -1.2234   -6.6267    0.0000 C   0  0
   -2.6917   -6.3197    0.0000 F   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
   -2.1567   -3.7722    0.0000 O   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -6.4995    3.7442    0.0000 Cl  0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
    1.2449   -5.8157    0.0000 C   0  0
    2.2449   -4.6977    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  2  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 16  1  0
 24 19  1  0
 22 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 28 30  1  0
 30 31  2  0
 31 25  1  0
 13 32  2  0
 32  8  1  0
 32 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28643

> <plate>
Kinase v5-2

> <well>
P19

> <supplier_cmpd_name>
Vemurafenib (PLX4032)

> <ctcr_id>
503

> <supplier_cmpd_id>
S1267

> <smiles>
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)c4ccc(Cl)cc4)c1F

> <pd_targets>
{BRAF,MAP2K1,MAP2K2,ARAF,CHRM1,RAF1,KDR,CHRM3,MAP3K20,CHRM2,FECH,KRAS}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Unclassified protein",Kinase,"Family A G protein-coupled receptor","Protein Kinase","Small molecule receptor (family A GPCR)","TKL protein kinase group","STE protein kinas
e group","Monoamine receptor","TK protein kinase group","TKL protein kinase RAF family","STE protein kinase STE7 family","Acetylcholine receptor","Tyrosine protein kinase VEGFR family","TKL protein ki
nase MLK family","TKL protein kinase MLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","G protein-coupled receptors","3.6.5.2 Small monomeric GTPases","Receptor kinases","Acetylcholine receptors (muscarinic)","RAS subfamily","TKL: Tyrosine kinase
-like","TK: Tyrosine kinase","RAF family","Receptor tyrosine kinases (RTKs)","Mixed Lineage Kinase (MLK) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","MLK subfamil
y"}

> <pathway_reactome>
{"Signal Transduction",Disease,Metabolism,"Neuronal System","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by GP
CR","MAPK family signaling cascades","Metabolism of porphyrins","Transmission across Chemical Synapses","Signaling by NTRKs","Oncogenic MAPK signaling","GPCR ligand binding","MAPK1/MAPK3 signaling","S
ignaling by VEGF","Heme biosynthesis","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by NTRK1 (TRKA)","Signaling by RAS mutants","Class A/1 (Rhodopsin-like receptors)","R
AF/MAP kinase cascade","VEGFA-VEGFR2 Pathway","Activation of NMDA receptors and postsynaptic events","Signalling to ERKs","Signaling downstream of RAS mutants","Amine ligand-binding receptors","Negati
ve regulation of MAPK pathway","VEGFR2 mediated cell proliferation","Post NMDA receptor activation events","Prolonged ERK activation events","Muscarinic acetylcholine receptors","Negative feedback reg
ulation of MAPK pathway","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","ARMS-mediated activation","Ras activation upon Ca2+ influx through NMDA receptor"}

> <broad_targets>
{BRAF,RAF1}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{Vemurafenib,918504-65-1,918504651,PLX4032,Zelboraf,1029872-54-5,1029872545,PLX-4032,RG7204,"PLX 4032","RG 7204","Vemurafenib (PLX4032, RG7204)",RO5185426,"RO 5185426",UNII-207SMY3FQT,UNII207SMY3FQT,"
Vemurafenib (PLX4032)",RG-7204,207SMY3FQT,CHEBI:63637,MFCD18074504,NSC761431,Ve,T2382,761431,S1267,"NSC 761431",vemurafenib}

> <pdid>
PD003414

> <targets>
{Raf,"B-RafV600E kinase Inhibitor",Autophagy}

> <classes>
{BRAF inhibitor,Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{42611257}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 44  0  0  0  0            999 V2000
   -1.2253  -11.9476    0.0000 C   0  0
    0.2010  -11.4832    0.0000 N   0  0
    0.5130  -10.0151    0.0000 C   0  0
   -0.6020   -9.0118    0.0000 O   0  0
    1.9401   -9.5505    0.0000 N   0  0
    2.2522   -8.0824    0.0000 C   0  0
    3.6778   -7.6159    0.0000 C   0  0
    3.9866   -6.1481    0.0000 C   0  0
    2.8699   -5.1466    0.0000 C   0  0
    1.4442   -5.6132    0.0000 C   0  0
    1.1354   -7.0810    0.0000 C   0  0
    3.1765   -3.6775    0.0000 C   0  0
    4.6014   -3.2088    0.0000 N   0  0
    4.9079   -1.7404    0.0000 C   0  0
    6.3335   -1.2714    0.0000 N   0  0
    7.4952   -1.3078    0.0000 C   0  0
    8.8665   -2.4552    0.0000 C   0  0
    8.7535   -4.0973    0.0000 C   0  0
    8.3168   -2.8279    0.0000 C   0  0
    8.6444   -1.4129    0.0000 C   0  0
    7.4084   -0.3312    0.0000 C   0  0
   10.0108   -1.4857    0.0000 O   0  0
    3.7896   -0.7408    0.0000 C   0  0
    3.7843    0.7584    0.0000 C   0  0
    2.3561    1.2167    0.0000 N   0  0
    1.5007    0.0000    0.0000 N   0  0
    0.0000    0.0000    0.0000 C   0  0
   -0.7540    1.2970    0.0000 C   0  0
   -2.2621    1.2970    0.0000 C   0  0
   -3.0162    0.0000    0.0000 C   0  0
   -2.2621   -1.2970    0.0000 C   0  0
   -0.7540   -1.2970    0.0000 C   0  0
   -3.8909    1.2065    0.0000 O   0  0
   -5.3236    0.7390    0.0000 C   0  0
   -5.3236   -0.7540    0.0000 C   0  0
   -3.8909   -1.2065    0.0000 O   0  0
    2.3647   -1.2095    0.0000 C   0  0
    2.0582   -2.6779    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 15  1  0
 20 22  1  0
 22 17  1  0
 14 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 27  1  0
 30 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 30  1  0
 26 37  1  0
 37 23  1  0
 37 38  2  0
 38 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28644

> <plate>
Kinase v5-2

> <well>
P21

> <supplier_cmpd_name>
WYE-125132

> <ctcr_id>
3214

> <supplier_cmpd_id>
S2661

> <smiles>
CNC(=O)Nc1ccc(cc1)c2nc(N3CC4CCC(C3)O4)c5cnn(C6CCC7(CC6)OCCO7)c5n2

> <pd_targets>
{MTOR,PIK3CA}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Lipid modifying kinases","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","FRAP subfami
ly"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,"RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","Signali
ng by FGFR in disease","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","Regulation of TP53 Activity","FGFR1 mutant receptor activation","Regulation of TP53 Expression and Degradat
ion","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{"YE125132 (WYE132",1144068-46-1,1144068461,WYE-125132,WYE125132,WYE-132,WYE132,"WYE 125132","WYE-125132 (WYE-132)","WYE125132 (WYE132)",CHEMBL601661,cc-15,cc15,SCHEMBL54355,MLS006011010,CHEBI:91364,D
TXSID70649521,HMS3265K19,HMS3265K20,HMS3265L19,HMS3265L20,HMS3656J09,AOB87378,BCP02227,EX,S2661}

> <pdid>
PD010899

> <targets>
{mTOR}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{25260757}

$$$$
UTKinase_V5
  SciTegic11012413002D

 11 12  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  2  1  0
 11  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28645

> <plate>
Kinase v5-2

> <well>
B04

> <supplier_cmpd_name>
3MA

> <ctcr_id>
1181

> <supplier_cmpd_id>
SY-3MA

> <smiles>
Cn1cnc(N)c2ncnc12

> <pd_targets>
{ADORA2A,ADORA1,ADORA2B}

> <pathway_gtopdb>
{"Membrane receptor","Family A G protein-coupled receptor","Small molecule receptor (family A GPCR)","Nucleotide-like receptor (family A GPCR)","Adenosine receptor"}

> <pathway_chembl>
{Receptors,"G protein-coupled receptors","Adenosine receptors"}

> <pathway_reactome>
{Disease,"Signal Transduction","Infectious disease","Signaling by GPCR","Leishmania infection","GPCR ligand binding","Leishmania parasite growth and survival","Class A/1 (Rhodopsin-like receptors)","A
nti-inflammatory response favouring Leishmania parasite infection","Nucleotide-like (purinergic) receptors","ADORA2B mediated anti-inflammatory cytokines production","Adenosine P1 receptors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{3Methyladenine,3-MA,3MA,S2767,T1879,SY-3MA,3-Methyladenine}

> <pdid>
PD006476

> <targets>
{PI3K,autophagy,Autophagy,"Endogenous Metabolite",Mitophagy}

> <classes>
{PI3K/Akt/mTOR,Autophagy,Metabolic Enzyme/Protease}

> <pubchem_cids>
{1673}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    3.8794   -1.4442    0.0000 C   0  0
    4.8823   -2.5608    0.0000 C   0  0
    4.5513   -4.0107    0.0000 C   0  0
    3.1755   -4.6084    0.0000 O   0  0
    5.8480   -4.7648    0.0000 N   0  0
    6.9651   -3.7649    0.0000 C   0  0
    8.4564   -3.9264    0.0000 C   0  0
    9.3418   -2.7156    0.0000 C   0  0
    8.7360   -1.3434    0.0000 C   0  0
    7.2447   -1.1820    0.0000 N   0  0
    6.3593   -2.3927    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21  2  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28646

> <plate>
Kinase v5-2

> <well>
B06

> <supplier_cmpd_name>
GW441756

> <ctcr_id>
7732

> <supplier_cmpd_id>
SY-GW441756

> <smiles>
Cn1cc(\C=C2/C(=O)Nc3cccnc23)c4ccccc14

> <pd_targets>
{FLT4,STK17A,MAP3K20,IRAK1,NEK4,CLK4,CSNK1A1,MAPK9,AURKA,MINK1,NTRK1,IRAK4,CAMK2G,FFP,CHEK2,IGF1R,RET,KMT2A,MEN1,PRKD2,SGK2,MARK2,ALK,LCK,CDK5,CLK2,MAP4K4,PHKG2,PIM1,PIM3,DYRK1A,MAP4K2,CSNK1D,NTRK2,NT
RK3,PKN2,MAP4K5,MAPT,RPS6KA3,BRSK1,INSR,LYN,SYK,ROCK1,PRKAA1,ITK,KDR,CDK1,AURKB,HIPK2,HIPK4,NEK2,STK3,PRKD3,ROCK2,MARK3,FER,FRK,SRC,GSK3B,SLK,BLK,FGFR1,CDK2,CSNK2A1,RPS6KB1,CAMK2D}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein",Kinase,Transferase,Reader,"Protein Kinase",Bromodomain,"TK protein kinase group","CAMK protein kinase group","TKL protein kinase group","Other 
protein kinase group","CMGC protein kinase group","CK1 protein kinase group","STE protein kinase group","AGC protein kinase group","Tyrosine protein kinase VEGFR family","CAMK protein kinase DAPK fami
ly","TKL protein kinase MLK family","TKL protein kinase IRAK family","Other protein kinase NEK family","CMGC protein kinase CLK family","CK1 protein kinase CK1 family","CMGC protein kinase MAPK family
","Other protein kinase AUR family","STE protein kinase STE20 family","Tyrosine protein kinase Trk family","CAMK protein kinase CAMK2 family","CAMK protein kinase RAD53 family","Tyrosine protein kinas
e InsR family","Tyrosine protein kinase Ret family","CAMK protein kinase PKD family","AGC protein kinase SGK family","CAMK protein kinase CAMK1 family","TKL protein kinase STKR family","Tyrosine prote
in kinase Src family","CMGC protein kinase CDK family","CAMK protein kinase PHk family","CAMK protein kinase PIM family","CMGC protein kinase DYRK family","AGC protein kinase PKN family","AGC protein 
kinase RSK family","Tyrosine protein kinase Syk family","AGC protein kinase DMPK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Fer family","CMGC protein kinase GSK family","Tyr
osine protein kinase FGFR family","Other protein kinase CK2 family","TKL protein kinase MLK subfamily","CMGC protein kinase JNK subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MARK 
subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase Dyrk1 subfamily","STE protein kinase KHS subfamily","AGC protein kinase RSK subfamily","
CAMK protein kinase BRSK subfamily","AGC protein kinase ROCK subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase HIPK subfamily","STE protein kina
se MST subfamily","STE protein kinase SLK subfamily","AGC protein kinase p70 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kin
ase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","TK: Tyrosine kinase","Death-associated kinase (DAPK) family","TKL: Tyrosine kinase
-like","Other protein kinases","CLK family","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","STE20 family","CAMK2 family","CAMK-like (CAMKL) family","Protein kinase D 
(PKD) family","SGK family","Cyclin-dependent kinase (CDK) family","Phosphorylase kinase (PHK) family","PIM family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Prote
in kinase N (PKN) family","RSK family","DMPK family","Glycogen synthase kinase (GSK) family","Receptor tyrosine kinases (RTKs)","Mixed Lineage Kinase (MLK) family","Interleukin-1 receptor-associated k
inase (IRAK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","JNK subfamily","Aurora kinase (Aur) family","MSN subfamily","CHK1 subfamily","MARK subfamily","Non-receptor tyrosine
 kinases (nRTKs)","CDK5 subfamily","Dyrk1 subfamily","KHS subfamily","RSK subfamily","BRSK subfamily","Rho kinase","AMPK subfamily","CDK1 subfamily","HIPK subfamily","MST subfamily","GSK subfamily","S
LK subfamily","Casein kinase 2 (CK2) family","p70 subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","MLK subfamily","Type VII RTKs: Neurotrophin receptor/Trk family"
,"Type II RTKs: Insulin receptor family","Type XIV RTKs: RET","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Src family","Syk family","Tec family","Fer family","Type V RTKs: FGF (fi
broblast growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Disease,"Gene expression (Transcription)","Cellular responses to external stimuli","Neuronal System","Developmental Biology",Metabolism,"Transport of small molec
ules","Cell Cycle","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription",
"Cellular responses to stress","Transmission across Chemical Synapses","Nervous system development","Metabolism of lipids","Ion channel transport","Infectious disease","Metabolism of carbohydrates",Mi
totic,"Signaling by Rho GTPases","Intracellular signaling by second messengers","Adaptive Immune System","Signaling by Hippo","MTOR signalling","Signaling by VEGF","Toll-like Receptor Cascades","Signa
ling by WNT in cancer","Generic Transcription Pathway","Cellular Senescence","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by Type 1 Insulin-like Gr
owth Factor 1 Receptor (IGF1R)","Axon guidance","Sphingolipid metabolism","Stimuli-sensing channels","HIV Infection","Glycogen metabolism","FLT3 signaling in disease","Mitotic G1 phase and G1/S transi
tion","Mitotic G2-G2/M phases","RHO GTPase Effectors","PIP3 activates AKT signaling","Leishmania infection","TCR signaling","Regulation of mitotic cell cycle","M Phase","Oncogenic MAPK signaling","Sig
naling by SCF-KIT","SARS-CoV Infections","Signaling by FGFR in disease","mTORC1-mediated signalling","VEGF ligand-receptor interactions","Toll Like Receptor 5 (TLR5) Cascade","Signaling by AMER1 mutan
ts","Transcriptional Regulation by TP53","Oxidative Stress Induced Senescence","Signaling by NTRK1 (TRKA)","Toll Like Receptor 2 (TLR2) Cascade","Activation of NMDA receptors and postsynaptic events",
"IGF1R signaling cascade","RET signaling","Sphingolipid de novo biosynthesis","Host Interactions of HIV factors","Glycogen breakdown (glycogenolysis)","Signaling by FLT3 ITD and TKD mutants","G0 and E
arly G1","G2/M Transition","Signaling by NTRK3 (TRKC)","RHO GTPases activate PKNs","Negative regulation of the PI3K/AKT network","Leishmania parasite growth and survival","Semaphorin interactions","Ge
neration of second messenger molecules","VEGFA-VEGFR2 Pathway","APC/C-mediated degradation of cell cycle proteins","Mitotic Metaphase and Anaphase","Signaling by RAS mutants","PTEN Regulation","SARS-C
oV-1 Infection","Transcriptional regulation by RUNX1","Signaling by FGFR1 in disease","VEGF binds to VEGFR leading to receptor dimerization","MyD88 cascade initiated on plasma membrane","Truncations o
f AMER1 destabilize the destruction complex","Regulation of TP53 Activity","Signalling to ERKs","Toll Like Receptor TLR6:TLR2 Cascade","Post NMDA receptor activation events","IRS-related events trigge
red by IGF1R","The role of Nef in HIV-1 replication and disease pathogenesis","STAT5 activation downstream of FLT3 ITD mutants","Centrosome maturation","Activation of TRKA receptors","Activated NTRK3 
signals through PI3K",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Anti-inflammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","VEGFR2 mediated cell proli
feration","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Mitotic Anaphase","Signaling downstream of RAS mutants","Regulation of PTEN stability and activity","SARS-CoV-
1 Genome Replication and Transcription","RUNX1 regulates transcription of genes involved in BCR signaling","FGFR1 mutant receptor activation","MAP kinase activation","Regulation of TP53 Activity throu
gh Phosphorylation","Prolonged ERK activation events","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Regula
tion of TP53 Expression and Degradation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Loss of proteins required for interphase microtubule organiza
tion from the centrosome","NGF-independant TRKA activation","Activation of AMPK downstream of NMDARs","FCGR3A-mediated IL10 synthesis","Sema4D induced cell migration and growth-cone collapse","APC/C:C
dc20 mediated degradation of mitotic proteins","Separation of Sister Chromatids","Signalling to RAS","Replication of the SARS-CoV-1 genome","Signaling by activated point mutants of FGFR1","activated T
AK1 mediates p38 MAPK activation","MAPK targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","Ras activation upon Ca2+ influx through NMDA receptor","Regulation of TP53 Degradat
ion","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","p38MAPK events
","Activation of the AP-1 family of transcription factors","CREB phosphorylation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","APC-Cdc20 mediated degradation of Nek2A"}

> <broad_targets>
{NTRK1}

> <broad_moa>
{"growth factor receptor inhibitor"}

> <synonyms>
{"GW 441756",504433-23-2,504433232,GW441756,GW-441756,CHEMBL176544,"(3Z)-3-((1-methylindol-3-yl)methylidene)-1H-pyrrolo(3,2-b)pyridin-2-one","(3Z)3((1methylindol3yl)methylidene)1Hpyrrolo(3,2b)pyridin2
one",C17H13N3O,QCR-77,QCR77,SCHEMBL5787769,CHEBI:92072,SYN1044,HMS3303P17,HMS3305D02,HMS3884D22,504433-24-3,504433243,EX-A1842,EXA1842,ZINC398,SY-GW441756}

> <pdid>
PD003852

> <targets>
{"Trk receptor"}

> <classes>
{}

> <pubchem_cids>
{9943465}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 29  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7238   -3.9526    0.0000 C   0  0
   -3.8385   -4.9563    0.0000 N   0  0
   -5.1376   -4.2063    0.0000 C   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -7.1983   -1.3700    0.0000 C   0  0
   -7.5102    0.0973    0.0000 C   0  0
   -8.9356    0.5610    0.0000 C   0  0
  -10.0503   -0.4427    0.0000 C   0  0
   -9.7384   -1.9099    0.0000 C   0  0
   -8.3118   -2.3734    0.0000 C   0  0
   -6.2112    0.8473    0.0000 N   0  0
   -5.0972   -0.1561    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9  5  1  0
  9 10  2  3
 10  2  1  0
  8 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  3
 14 15  1  0
 15 11  1  0
 15 16  2  3
 16 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 21  1  0
 21 22  1  0
 22 17  1  0
 18 23  1  0
 23 24  2  3
 24  7  1  0
 24 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28647

> <plate>
Kinase v5-2

> <well>
B08

> <supplier_cmpd_name>
K-252c

> <ctcr_id>
5614

> <supplier_cmpd_id>
SY-K-252c

> <smiles>
O=C1CCC2=NC3=C(C2=C1)C4=CN=CC4=C5C6=C(C=CCC6)N=C35

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{K252c,SY-K-252c,K-252c}

> <pdid>

> <targets>
{PKC/PKA}

> <classes>
{}

> <pubchem_cids>
{44450656}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.9511   -0.8815    0.0000 N   0  0
   -4.9530   -1.9978    0.0000 C   0  0
   -4.2010   -3.2957    0.0000 N   0  0
   -2.7343   -2.9815    0.0000 C   0  0
   -1.6115   -3.9772    0.0000 C   0  0
   -0.1605   -3.6178    0.0000 C   0  0
    0.8791   -4.6991    0.0000 C   0  0
    0.4626   -6.1401    0.0000 C   0  0
    1.5022   -7.2213    0.0000 F   0  0
   -0.9936   -6.4998    0.0000 C   0  0
   -2.0333   -5.4186    0.0000 C   0  0
   -4.2568    0.5878    0.0000 C   0  0
   -3.2235    1.6679    0.0000 C   0  0
   -3.6446    3.1076    0.0000 C   0  0
   -5.1020    3.4627    0.0000 N   0  0
   -6.1382    2.3782    0.0000 C   0  0
   -5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  9  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 14  1  0
 10 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28648

> <plate>
Kinase v5-2

> <well>
B10

> <supplier_cmpd_name>
SB242235

> <ctcr_id>
5194

> <supplier_cmpd_id>
SY-SB242235

> <smiles>
COc1nccc(n1)c2n(cnc2c3ccc(F)cc3)C4CCNCC4

> <pd_targets>
{CSNK1D,PRKACA,PRKCB,MAP4K5,MAPK14,PRKCA,MAP4K4,MINK1,CSNK1A1,PRKD3,HSPB1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein",Kinase,"Protein Kinase","CK1 protein kinase group","AGC protein kinase group","STE protein kinase group","CMGC protein kinase group","CAMK protein kinase group","CK1 
protein kinase CK1 family","AGC protein kinase PKA family","AGC protein kinase PKC family","STE protein kinase STE20 family","CMGC protein kinase MAPK family","CAMK protein kinase PKD family","AGC pro
tein kinase PKC alpha subfamily","STE protein kinase KHS subfamily","CMGC protein kinase p38 subfamily","STE protein kinase MSN subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"C
LK families","CAMK: Calcium/calmodulin-dependent protein kinases","Casein kinase 1 (CK1) family","Protein kinase A (PKA) family","Protein kinase C (PKC) family","STE20 family","Mitogen-activated prote
in kinases (MAP kinases)","Protein kinase D (PKD) family","Alpha subfamily","KHS subfamily","p38 subfamily","Delta subfamily","MSN subfamily"}

> <pathway_reactome>
{"Cell Cycle","Immune System","Signal Transduction","Cellular responses to external stimuli",Disease,Metabolism,Mitotic,"Innate Immune System","Signaling by GPCR","Cellular responses to stress","Disea
ses of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","Signaling by Nuclear Receptors","Mitotic G2-G2/M phases","M Phase","Toll-like Receptor Cascades","G
PCR downstream signalling","Cellular Senescence","Signaling by WNT in cancer","Sphingolipid metabolism","ESR-mediated signaling","G2/M Transition","Mitotic Prophase","Toll Like Receptor 5 (TLR5) Casca
de","G alpha (i) signalling events","Oxidative Stress Induced Senescence","Signaling by AMER1 mutants","Sphingolipid de novo biosynthesis","Extra-nuclear estrogen signaling","Centrosome maturation","N
uclear Envelope Breakdown","MyD88 cascade initiated on plasma membrane","Visual phototransduction","Truncations of AMER1 destabilize the destruction complex","Loss of proteins required for interphase 
microtubule organization from the centrosome","Depolymerisation of the Nuclear Lamina","MAP kinase activation","The phototransduction cascade","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuc
lear events mediated by MAP kinases",Inactivation,"recovery and regulation of the phototransduction cascade","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{HSPB1,MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{193746-75-7,193746757,SB242235,SB-242235,"SB 242235",4-(5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl)-2-methoxypyrimidine,4(5(4fluorophenyl)3piperidin4ylimidazol4yl)2methoxypyrimidine,CHEMBL95692
,Kinome_3169,Kinome3169,Kinome-3169,"Kinome 3169",SCHEMBL2267209,BDBM15458,SYN1076,HMS3244I17,HMS3244I18,HMS3244J17,BCP05992,EX-A1881,EXA1881,ZINC1487129,3254AH,AKO,T4078,SY-SB242235}

> <pdid>
PD012436

> <targets>
{"p38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{9863367}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    1.2948   -3.7516    0.0000 C   0  0
    2.5951   -3.0039    0.0000 S   0  0
    3.8926   -3.7566    0.0000 O   0  0
    2.5923   -4.5039    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -7.7891   -1.5185    0.0000 S   0  0
   -7.7834   -3.0185    0.0000 O   0  0
   -9.0852   -2.2736    0.0000 O   0  0
   -9.0919   -0.7734    0.0000 C   0  0
  -10.3891   -1.5283    0.0000 C   0  0
  -11.8101   -1.4906    0.0000 C   0  0
  -11.0529   -2.7854    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  2  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 14 17  1  0
 17 18  2  0
 17 19  2  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 21  1  0
  9 24  1  0
 24 25  2  0
 25  6  1  0
M  END
> <name>
UTKinase_V5

> <id>
28649

> <plate>
Kinase v5-2

> <well>
B12

> <supplier_cmpd_name>
MMP-2 Inhibitor II

> <ctcr_id>
4943

> <supplier_cmpd_id>
SY-MMP-2 Inhibitor II

> <smiles>
C[S](=O)(=O)Nc1ccc(Oc2ccc(cc2)[S](=O)(=O)CC3CO3)cc1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"MP2 INHIBITOR I","MMP-2 Inhibitor II","MMP2 Inhibitor II",869577-51-5,869577515,N-(4-(4-(oxiran-2-ylmethylsulfonyl)phenoxy)phenyl)methanesulfonamide,N(4(4(oxiran2ylmethylsulfonyl)phenoxy)phenyl)meth
anesulfonamide,SCHEMBL314080,(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane,(4(4(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane,N-(4-(4-((2-oxiranylmethyl)sulfonyl)phenoxy)phe
nyl)-met,N(4(4((2oxiranylmethyl)sulfonyl)phenoxy)phenyl)met,"SY-MMP-2 Inhibitor II"}

> <pdid>
PD017845

> <targets>
{MMP2}

> <classes>
{}

> <pubchem_cids>
{15940371}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    1.6317   -2.2458    0.0000 C   0  0
    0.7500   -1.0323    0.0000 C   0  0
    1.2135    0.3943    0.0000 N   0  0
    0.0000    1.2760    0.0000 C   0  0
   -0.0031    2.7742    0.0000 N   0  0
   -1.3040    3.5228    0.0000 C   0  0
   -2.6017    2.7705    0.0000 O   0  0
   -1.3071    5.0236    0.0000 N   0  0
   -0.0936    5.8834    0.0000 C   0  0
   -0.5571    7.3100    0.0000 C   0  0
   -2.0571    7.3100    0.0000 C   0  0
   -2.5206    5.8834    0.0000 C   0  0
   -3.9429    5.4124    0.0000 C   0  0
   -5.0639    6.4090    0.0000 O   0  0
   -4.2459    3.9433    0.0000 N   0  0
   -1.2135    0.3943    0.0000 S   0  0
   -0.7500   -1.0323    0.0000 C   0  0
   -1.6321   -2.2464    0.0000 C   0  0
   -3.1114   -2.3441    0.0000 C   0  0
   -3.4619   -3.8026    0.0000 S   0  0
   -2.1831   -4.5866    0.0000 C   0  0
   -1.0423   -3.6127    0.0000 N   0  0
   -2.0659   -6.0803    0.0000 C   0  0
   -3.3018   -6.9304    0.0000 C   0  0
   -0.7120   -6.7259    0.0000 C   0  0
   -1.9479   -7.5756    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  8  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
  4 16  1  0
 16 17  1  0
 17  2  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 18  1  0
 21 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28650

> <plate>
Kinase v5-2

> <well>
B14

> <supplier_cmpd_name>
A66

> <ctcr_id>
1915

> <supplier_cmpd_id>
SY-A66

> <smiles>
Cc1nc(NC(=O)N2CCCC2C(=O)N)sc1c3csc(n3)C(C)(C)C

> <pd_targets>
{PIK3CB,PIK3CG,PIK3C2B,PIK3CA,PIK3CD}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidylinositol-4-phosphate 3-kinase family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,Disease,"Immune System","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second messeng
ers","Cytokine Signaling in Immune system","Signaling by Insulin receptor","Phospholipid metabolism","Signaling by FGFR in disease","Signaling by Interleukins","Insulin receptor signalling cascade","P
I Metabolism","Signaling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","IRS-mediated signalling","Synthesis of PIPs at the plasma membrane","FGFR1 mutant receptor activation"
,"Interleukin receptor SHC signaling","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
{PIK3CA}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{SCHEMBL12700770,HMS3656L07,HMS3672C17,AKOS026750475,NCGC00389613-01,NCGC0038961301,AK279970,SY-A66,S2636,A66}

> <pdid>
PD010905

> <targets>
{PI3K,PIK3,"alpha PIK3CA"}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{74832860}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    6.4924   -3.7566    0.0000 C   0  0
    5.1945   -3.0045    0.0000 N   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    3.9015    0.7475    0.0000 O   0  0
    5.1969   -1.5045    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
    0.0036   -7.4988    0.0000 C   0  0
   -1.2942   -8.2509    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 C   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -3.8971   -5.2550    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  2  1  0
  5  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  1  0
 21  9  1  0
 21 15  2  0
 19 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28651

> <plate>
Kinase v5-2

> <well>
B16

> <supplier_cmpd_name>
Flavopiridol (HMR-1275, Alvocidib, L868275)

> <ctcr_id>
576

> <supplier_cmpd_id>
SY-Flavopiridol

> <smiles>
CN1CCC(C(O)C1)c2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccccc4Cl

> <pd_targets>
{PIP5K1C,DSTYK,EGFR,PYGM,CAMKK1,CDK16,CDK2,CAMK2A,RPS6KA2,MKNK2,CLK1,CAMK2B,CDK14,AXL,RPS6KA6,STK3,CIT,CSF1R,CDK3,NUAK2,EPHA1,CCNE1,CCNE2,CCNB1,CCNB2,CCNB3,CDK1,CCND1,CDK4,PRKCE,PRKCH,KIT,ACVR2B,ALK,A
CVRL1,MAP4K1,ULK2,IRAK4,CDK15,LRRK2,DYRK1A,PRKCD,PIM3,GSK3A,ABL1,PRKCQ,MAPK7,RPS6KA4,AAK1,EIF2AK2,STK32A,IRAK1,CDK6,CAMKK2,CRK2,GAK,EPHA5,STK17B,FLT3,CDK17,CDK18,PHKG1,CDK19,CDK8,MAP3K9,CDC42BPB,DCLK1
,DCLK3,CDK13,MAPK3,CDK7,CDK9,CCND2,CCND3,CDK5,CDK5R1,PIM1,CLK2,PHKG2,MAP3K10,SRMS,PKN1,TBK1,TAOK3,CCNT1,CCNA2,PRKCA,PRKCB,PRKCG,PRKCI,PRKCZ,PRKD1,PRKD3,LCK,PDGFRA,MERTK,TAOK2,TAOK1,MAP3K7,CSNK1A1L,DYR
K1B,MAP2K3,MAPK15,PRKD2,RPS6KA1,MINK1,IKBKE,ACVR1,MAPK10,GRK1,CDKL5,CCNA1,CAMK2G,DMPK,STK17A,HIPK2,GRK7,GSK3-BETA,CCNH,PIM2,EPHB1,PRKAA1,FRK,PTK2B,CDC42BPA,EPHA3,MAPK8,JAK3,RPS6KA3,CSNK1A1,MAP4K2,TYK2
,JAK2,MAP4K3,ROCK1,CILK1,STK35,PLK4,CAMK4,CSNK1G1,SRC,GSK3B,BMPR1B,MAP3K3,RPS6KB1,STK33,TNNI3K,LTK,MAP2K4,VRK2,EIF2AK1,PIP4K2C,HIPK4,MAP2K5,HIPK1,ERBB4,ERBB3,ROCK2,CLK3,RPS6KA5,CAMK2D,TGFBR2,EPHA2,LAR
P7,ERBB2,ACVR2A,HIPK3,MAK,MAP3K2,MNAT1,GRK5,MAPK13,CLK4,MATK,MAPK14,SRPK1,MAPK12,MAP4K5,PKN2,SYK,ROS1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Transferase,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","CMGC protein kinase group","CAMK protein kinase group","AGC protein kinase gr
oup","STE protein kinase group","TKL protein kinase group","CK1 protein kinase group","Tyrosine protein kinase EGFR family","Other protein kinase CAMKK family","CMGC protein kinase CDK family","CAMK p
rotein kinase CAMK2 family","AGC protein kinase RSK family","CAMK protein kinase MAPKAPK family","CMGC protein kinase CLK family","Tyrosine protein kinase Axl family","STE protein kinase STE20 family"
,"AGC protein kinase DMPK family","Tyrosine protein kinase PDGFR family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Eph family","AGC protein kinase PKC family","TKL protein kinase STK
R family","Other protein kinase ULK family","TKL protein kinase IRAK family","TKL protein kinase LRRK family","CMGC protein kinase DYRK family","CAMK protein kinase PIM family","CMGC protein kinase GS
K family","Tyrosine protein kinase Abl family","CMGC protein kinase MAPK family","Other protein kinase NAK family","Other protein kinase PEK family","AGC protein kinase YANK family","CAMK protein kina
se DAPK family","CAMK protein kinase PHk family","TKL protein kinase MLK family","CAMK protein kinase DCAMK1 family","Tyrosine protein kinase Src family","AGC protein kinase PKN family","Other protein
 kinase IKK family","CK1 protein kinase CK1 family","STE protein kinase STE7 family","CAMK protein kinase PKD family","AGC protein kinase GRK family","CMGC protein kinase CDKL family","Tyrosine protei
n kinase Fak family","Tyrosine protein kinase JakA family","CMGC protein kinase RCK family","Other protein kinase NKF4 family","Other protein kinase PLK family","STE protein kinase STE11 family","CAMK
 protein kinase unique family","Tyrosine protein kinase Alk family","Other protein kinase Meta subfamily","CMGC protein kinase TAIRE subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase
 RSK subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase PFTAIRE","STE protein kinase MST subfamily","AGC protein kinase CRIK subfamily","CAMK protein kinase NuaK subfamily","AGC prote
in kinase PKC eta subfamily","TKL protein kinase STKR Type 2 subfamily","TKL protein kinase STKR Type 1 subfamily","STE protein kinase KHS subfamily","CMGC protein kinase Dyrk1 subfamily","AGC protein
 kinase PKC delta subfamily","CMGC protein kinase ERK5","AGC protein kinase MSK subfamily","Other protein kinase PKR","CMGC protein kinase PCTAIRE","CMGC protein kinase CDK8 subfamily","TKL protein ki
nase MLK subfamily","AGC protein kinase GEK subfamily","CMGC protein kinase ERK1","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK5 subfamily","Tyrosi
ne protein kinase Srm","STE protein kinase TAO subfamily","AGC protein kinase PKC alpha subfamily","TKL protein kinase TAK1 subfamily","CK1 protein kinase CK1-a","STE protein kinase MSN subfamily","TK
L protein kinase STKR1","CMGC protein kinase JNK subfamily","AGC protein kinase GRK subfamily","CMGC protein kinase HIPK subfamily","CAMK protein kinase AMPK subfamily","AGC protein kinase ROCK subfam
ily","CMGC protein kinase MAK","STE protein kinase MEKK2","AGC protein kinase p70 subfamily","TKL protein kinase HH498 subfamily","Other protein kinase HRI","Tyrosine protein kinase Csk family","CMGC 
protein kinase SRPK family","Tyrosine protein kinase Syk family","Tyrosine protein kinase Sev family","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein
 kinases","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5
-kinase family)","Other protein kinases","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","CAMK2 family","RSK family","MAPK-Activated Protein Kinase (MAPKAPK) family","CLK family","STE20 f
amily","DMPK family","CAMK-like (CAMKL) family","Protein kinase C (PKC) family","TKL: Tyrosine kinase-like","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","PIM family",
"Glycogen synthase kinase (GSK) family","Mitogen-activated protein kinases (MAP kinases)","YANK family","Death-associated kinase (DAPK) family","Phosphorylase kinase (PHK) family","DCAMKL family","Pro
tein kinase N (PKN) family","Casein kinase 1 (CK1) family","STE7 family","Protein kinase D (PKD) family","G protein-coupled receptor kinases (GRKs)","Cyclin-dependent kinase-like (CDKL) family","RCK f
amily","CAMK1 family","STE11 family","CAMK-unique family","Vaccina related kinase (VRK) family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Other-unique family","Recept
or tyrosine kinases (RTKs)","CAMKK family","TAIRE subfamily","CDK1 subfamily","RSK subfamily","MKN subfamily","MST subfamily","Other DMPK family kinases","NuaK subfamily","Eta subfamily","Receptor ser
ine/threonine kinase (RSTK) family","KHS subfamily","Unc-51-like kinase (ULK) family","Interleukin-1 receptor-associated kinase (IRAK) family","Leucine-rich repeat kinase (LRRK) family","Dyrk1 subfami
ly","CDK4 subfamily","Delta subfamily","GSK subfamily","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","MSK subfamily","NAK family","PEK family","Numb-associated kinase (NAK) family","CDK8 sub
family","Mixed Lineage Kinase (MLK) family","GEK subfamily","CRK7 subfamily","CDK7 subfamily","CDK9 subfamily","CDK5 subfamily","IKK family","TAO subfamily","Erk7 subfamily","MSN subfamily","JNK subfa
mily","Opsin/rhodopsin kinases","HIPK subfamily","AMPK subfamily","Rho kinase","NKF4 family","Polo-like kinase (PLK) family","p70 subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor famil
y","Meta subfamily","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIII RTKs: Ephrin receptor family","Type II receptor ser
ine/threonine kinases","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type I receptor serine/threonine kinases","Abl family","Other PEK family kinases","MLK subfamily","Src family",
"TAK1 subfamily","Fak family","Janus kinase (JakA) family","HH498 subfamily","SRPK family","GRK4 subfamily","p38 subfamily","Csk family","Syk family","Type XVII RTKs: ROS receptors"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction",Metabolism,"Neuronal System","Gene expression (Transcription)","Immune System",Disease,"Cell Cycle","Vesicle-mediated transport",Hemostasis,"Cellular res
ponses to external stimuli","Muscle contraction","Nervous system development","Signaling by GPCR","Metabolism of carbohydrates","Transmission across Chemical Synapses","RNA Polymerase II Transcription
","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Signaling by Hippo","Signaling by Rho GTPases","Diseases of signal transduction by growth factor receptors and second messengers","Si
gnaling by NODAL","Signaling by TGFB family members","Signaling by Non-Receptor Tyrosine Kinases",Mitotic,"Intracellular signaling by second messengers","Infectious disease","Membrane Trafficking","Me
tabolism of lipids","Cell surface interactions at the vascular wall","Cellular responses to stress","Cardiac conduction","Cytokine Signaling in Immune system","Disorders of Developmental Biology","MTO
R signalling","Axon guidance","GPCR downstream signalling","Glycogen metabolism","Neurotransmitter receptors and postsynaptic signal transmission","Generic Transcription Pathway","Toll-like Receptor C
ascades","Signaling by VEGF","RHO GTPase Effectors","Fcgamma receptor (FCGR) dependent phagocytosis","Signaling by KIT in disease","Regulation of signaling by NODAL","Signaling by BMP","Signaling by P
TK6","Mitotic G1 phase and G1/S transition","DAG and IP3 signaling","SARS-CoV Infections","Leishmania infection","Clathrin-mediated endocytosis","Influenza Infection","trans-Golgi Network Vesicle Budd
ing","Signaling by Insulin receptor","Regulation of lipid metabolism by PPARalpha","Signaling by NOTCH1 in Cancer","HIV Infection","FLT3 signaling in disease","Signaling by PDGFR in disease","M Phase"
,"Sphingolipid metabolism","Cellular Senescence","Regulation of mitotic cell cycle","Ion homeostasis","PIP3 activates AKT signaling","Signaling by Interleukins","Signaling by WNT in cancer","Interfero
n Signaling","Mitotic G2-G2/M phases","Disorders of Nervous System Development","Signaling by NTRKs","mTORC1-mediated signalling","Response of EIF2AK1 (HRI) to heme deficiency","Signaling by TGF-beta 
Receptor Complex in Cancer","Semaphorin interactions","G alpha (q) signalling events","Glycogen breakdown (glycogenolysis)","Activation of NMDA receptors and postsynaptic events","Transcriptional Regu
lation by TP53","Toll Like Receptor 5 (TLR5) Cascade","VEGFA-VEGFR2 Pathway","RHO GTPases activate CIT","Transcriptional Regulation by VENTX","EPH-Ephrin signaling","Role of phospholipids in phagocyto
sis","G alpha (z) signalling events","Drug resistance of KIT mutants","Toll Like Receptor 2 (TLR2) Cascade","PTK6 promotes HIF1A stabilization","G0 and Early G1","G1 Phase","CaM pathway","SARS-CoV-1 I
nfection","Parasite infection","G alpha (i) signalling events","L1CAM interactions","Cargo recognition for clathrin-mediated endocytosis","NS1 Mediated Effects on Host Pathways","Golgi Associated Vesi
cle Biogenesis","Insulin receptor signalling cascade","PPARA activates gene expression","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","HIV Life Cycle","Signaling by FLT3 ITD and TKD mutants",
"PTK6 Down-Regulation","RHO GTPases activate PKNs","Toll Like Receptor 4 (TLR4) Cascade","Host Interactions of HIV factors","Drug resistance of PDGFR mutants","Mitotic Metaphase and Anaphase","Sphingo
lipid de novo biosynthesis","Oxidative Stress Induced Senescence","APC/C-mediated degradation of cell cycle proteins","PTEN Regulation","Interleukin-2 family signaling","Signaling by AMER1 mutants","I
nterferon alpha/beta signaling","G2/M Transition","Pervasive developmental disorders","Signaling by NTRK1 (TRKA)","Interleukin-1 family signaling","Negative regulation of the PI3K/AKT network","Loss o
f Function of SMAD2/3 in Cancer","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Gastrin-CREB signalling pathway via PKC and MAPK","Post NMDA receptor activation events","Regulati
on of TP53 Activity","MyD88 cascade initiated on plasma membrane","EPHA-mediated growth cone collapse","Dasatinib-resistant KIT mutants","Toll Like Receptor TLR6:TLR2 Cascade","Cyclin D associated eve
nts in G1","Calmodulin induced events","SARS-CoV-1 Genome Replication and Transcription","Leishmania phagocytosis","Visual phototransduction","Recycling pathway of L1","Inhibition of PKR","IRS-mediate
d signalling","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","TP53 Regulates Transcription of DNA Repair Genes","Late Phase of HIV Life Cycle","STAT5 activation downstream of FLT3 ITD mutan
ts","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","MyD88-independent TLR4 cascade","The role of Nef in HIV-1 replication and disease pathogenesis","
Imatinib-resistant PDGFR mutants","Mitotic Anaphase","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","EPHB-mediated forward signaling","Regulation of PTEN stability and 
activity","Interleukin-2 signaling","Interleukin-15 signaling","Truncations of AMER1 destabilize the destruction complex","Regulation of IFNA signaling","Sema4D in semaphorin signaling","Centrosome ma
turation","Loss of function of MECP2 in Rett syndrome","Signalling to ERKs","Interleukin-1 signaling","Signalling to ERK5",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","SMAD2/3 Phosphorylation Mot
if Mutants in Cancer","EGFR Transactivation by Gastrin","Activation of RAC1 downstream of NMDARs","Regulation of TP53 Expression and Degradation","CREB1 phosphorylation through NMDA receptor-mediated 
activation of RAS signaling","MAP kinase activation","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Replication of the SARS-CoV-1 genome","FCGR3A-mediated phagocytosis","The phototransductio
n cascade","Activation of AMPK downstream of NMDARs","PI3K Cascade","Transcription of the HIV genome","Regulation of TP53 Activity through Phosphorylation","TRIF(TICAM1)-mediated TLR4 signaling","Nef-
mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Separation of Sister Chromatids","APC/C:Cdc20 mediated degradation of mitotic proteins","Sema4D induced cel
l migration and growth-cone collapse","Loss of proteins required for interphase microtubule organization from the centrosome","Loss of phosphorylation of MECP2 at T308","Signalling to RAS","Nuclear En
velope (NE) Reassembly","Regulation of TP53 Activity through Acetylation","Long-term potentiation","Regulation of TP53 Degradation","Ras activation upon Ca2+ influx through NMDA receptor","MAPK target
s/ Nuclear events mediated by MAP kinases","RSK activation",Inactivation,"recovery and regulation of the phototransduction cascade","activated TAK1 mediates p38 MAPK activation","HIV Transcription Elo
ngation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Nef Mediated CD4 Down-regulation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","APC:Cdc20 mediated degradation of cel
l cycle proteins prior to satisfation of the cell cycle checkpoint","Loss of Nlp from mitotic centrosomes","p38MAPK events","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated h
uman TAK1","Initiation of Nuclear Envelope (NE) Reformation","PI5P Regulates TP53 Acetylation","CREB phosphorylation","ERK/MAPK targets","Tat-mediated elongation of the HIV-1 transcript","Activation o
f the AP-1 family of transcription factors","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERKs are inactivated","Formation of HIV-1 elongation complex containing HIV-1 Tat","Signaling by ERB
B2","Downregulation of ERBB2 signaling","Leishmania parasite growth and survival","Anti-inflammatory response favouring Leishmania parasite infection","FCGR3A-mediated IL10 synthesis"}

> <broad_targets>
{CDK1,CDK2,CDK4,CDK5,CDK6,CDK7,CDK8,CDK9,EGFR,PYGM}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{Flavopiridol,146426-40-6,146426406,Kinome_3211,Kinome3211,Kinome-3211,"Kinome 3211",Kinome_3213,Kinome3213,Kinome-3213,"Kinome 3213",Neuro_000356,Neuro000356,Neuro-000356,"Neuro 000356",CHEMBL422897,
SCHEMBL5868074,BDBM384357,HMS3244M03,HMS3244M04,HMS3244N03,HMS3265A23,HMS3265A24,HMS3265B23,HMS3265B24,NSC642740,"US9932327, Compound Flavopiridol",AKOS0329,T2615,SY-Flavopiridol,S1230,"Flavopiridol h
ydrochloride","Flavopiridol (HMR-1275, Alvocidib, L868275)",Flavopiridol(Alvocidib)}

> <pdid>
PD003362

> <targets>
{CDK}

> <classes>
{}

> <pubchem_cids>
{5466794}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 31  0  0  0  0            999 V2000
    7.6082   -1.1203    0.0000 H   0  3
    5.1082   -1.1203    0.0000 Cl  0  5
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0049   -5.9994    0.0000 C   0  0
    0.0102   -7.4994    0.0000 C   0  0
    1.3118   -8.2449    0.0000 C   0  0
    2.6082   -7.4904    0.0000 O   0  0
    2.6030   -5.9904    0.0000 C   0  0
    1.3014   -5.2449    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 O   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -3.9073    5.2404    0.0000 C   0  0
   -5.2089    5.9859    0.0000 F   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -0.0128    6.0039    0.0000 F   0  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
 12 20  1  0
 20 21  2  0
 21  4  1  0
 21  9  1  0
  7 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  2  0
 29 23  1  0
 29 30  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28652

> <plate>
Kinase v5-2

> <well>
B18

> <supplier_cmpd_name>
R1487  (SY-R1487)

> <ctcr_id>
1000

> <supplier_cmpd_id>
SY-R1487

> <smiles>
[H+].[Cl-].CN1C(=O)C(=Cc2cnc(NC3CCOCC3)nc12)Oc4ccc(F)cc4F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"1487 (SYR1487",449808-64-4,449808644,"R1487 (Hydrochloride)","R1487 HCl",R1487,"R1487 Hydrochloride","R-1487 Hydrochloride",C19H18F2N4O3.HCl,CHEMBL1766582,SCHEMBL20582726,DTXSID60712354,EX-A670,EXA6
70,SYN1101,BCP01963,MFCD18711690,AKOS030622859,CS-5860,CS5860,QC-6149,QC6149,HY-1497,HY1497,SY-R1487,"R1487  (SY-R1487)"}

> <pdid>

> <targets>
{MAPK(p38MAP),"p38 MAPK",Autophagy}

> <classes>
{Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{54580957}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0049   -5.9994    0.0000 C   0  0
    0.0102   -7.4994    0.0000 C   0  0
    1.3118   -8.2449    0.0000 C   0  0
    2.6082   -7.4904    0.0000 C   0  0
    2.6030   -5.9904    0.0000 C   0  0
    1.3014   -5.2449    0.0000 C   0  0
    3.8986   -5.2328    0.0000 C   0  0
    5.2016   -5.9761    0.0000 O   0  0
    3.8913   -3.7329    0.0000 O   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2978    3.7529    0.0000 C   0  0
    2.5981    3.0050    0.0000 Cl  0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 C   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -2.5981    2.9968    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 16 18  1  0
 18 19  1  0
 18 20  2  0
 10 21  1  0
 21 22  2  0
 22  2  1  0
 22  7  1  0
  5 23  1  0
 23 24  2  0
 24 25  1  0
 24 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 23  1  0
 29 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28653

> <plate>
Kinase v5-2

> <well>
B20

> <supplier_cmpd_name>
PD173955-Analogue 1

> <ctcr_id>
5394

> <supplier_cmpd_id>
SY-PD173955-Analogue 1

> <smiles>
CN1C(=O)C(=Cc2cnc(Nc3cccc(c3)C(O)=O)nc12)c4c(Cl)cccc4Cl

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{D173955ANALOGUE,185039-99-0,185039990,PD173955-Analog1,PD173955Analog1,"PD-173955 Analogue 1","PD173955 Analogue 1",C21H14Cl2N4O3,"2-aminopyrido(2,3-d)pyrimidin-7(8H)-one 70","2aminopyrido(2,3d)pyrim
idin7(8H)one 70",BDBM3103,CHEMBL109631,SCHEMBL5764437,SYN1062,ZINC3815299,NCGC00345830-01,NCGC0034583001,NCGC00345830-02,NCGC0034583002,AS-16218,AS16218,DB-065507,DB065507,FT-0741994,FT0741994,J-5107,
J5107,"SY-PD173955-Analogue 1","PD173955-Analogue 1"}

> <pdid>

> <targets>
{c-Src}

> <classes>
{}

> <pubchem_cids>
{5327916}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 34  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
   -2.5764   -7.5048    0.0000 N   0  0
   -1.2730   -8.2489    0.0000 C   0  0
    0.0221   -7.4921    0.0000 O   0  0
   -1.2647   -9.7497    0.0000 N   0  0
    0.0387  -10.4937    0.0000 C   0  0
    0.0491  -11.9937    0.0000 C   0  0
    1.3533  -12.7347    0.0000 C   0  0
    2.6472  -11.9757    0.0000 C   0  0
    2.6368  -10.4758    0.0000 C   0  0
    1.3326   -9.7348    0.0000 C   0  0
    3.9514  -12.7167    0.0000 Cl  0  0
    1.3637  -14.2355    0.0000 C   0  0
    0.0704  -14.9953    0.0000 F   0  0
    2.6682  -14.9761    0.0000 F   0  0
    1.3748  -15.7355    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  3
 10  5  1  0
  9 11  1  0
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  3
 15 16  1  0
 16 17  2  3
 17 12  1  0
 15 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  2  3
 23 24  1  0
 24 25  2  3
 25 26  1  0
 26 27  2  3
 27 22  1  0
 25 28  1  0
 24 29  1  0
 29 30  1  0
 29 31  1  0
 29 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28654

> <plate>
Kinase v5-2

> <well>
B22

> <supplier_cmpd_name>
Sorafenib    (Nexavar,    BAY43-9006)

> <ctcr_id>
1772

> <supplier_cmpd_id>
SY-Sorafenib

> <smiles>
CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

> <pd_targets>
{EPHA6,RAF1,MKNK2,EPHA5,FLT4,FLT3,MAPK12,HTR7,BRAF,CSF1R,CDK17,CDK14,AURKA,AXL,CAMK2B,RET,FGR,MAP2K5,ARAF,KDR,CDK8,KIT,MAPK14,FRK,EPHA8,ABL2,EPHA4,SLK,FGFR1,RIPK2,NTRK1,STK36,LCK,MAPK13,STK33,TNNI3K,D
DR2,LYN,AURKC,TAOK3,PDGFRB,MYLK3,ABL1,STK10,CLK1,TTK,MAPK15,CIT,TEK,HTR6,CDK7,SRMS,MINK1,KMT2A,MEN1,FGFR2,EPHA2,FGFR3,TAOK1,CDK19,DDR1,EPHB4,FLT1,MYLK2,CDK2,HIPK2,MAPK11,EPHA7,MAP4K5,LIMK1,MAPK9,HIPK4
,EPHA3,MKNK1,SRPK1,TNK1,AURKB,CDKL2,CDKL3,HIPK1,CCNC,MAPK1,EGFR,TGFBR2,HTR2B,CDK5,MAP3K20,MAP4K4,PDGFRA,TIE1,RPS6KA6,FYN,EPHB1,EPHB2,NTRK2,TNIK,NTRK3,MUSK,HIPK3,EPHA1,IRAK1,RORC,MERTK,EPHB6,NLK,MAPK3,
DYRK3,CDK3,NTSR1,RPS6KB1,PLK2,MAP3K7,LIMK2,HCK,HTR2C,CDK15,HTR2A,EPHX2,PLK4,MAP4K1,CDPK1,HTR5A,MYO3B,ABCB11,CSNK1A1,MAP3K19,MET,TAOK2,CSK,JAK3,BLK,RIPK1,CCNA2,HTR1A,SRC,GSK3B,INSR,CA7,CYP19A1,MAP2K1,R
IPK3,PAX8,LMP1,MC4R}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Epigenetic regulator","Transcription factor","Unclassified protein",Transporter,Kinase,"Family A G protein-coupled receptor",Reader,"Nuclear receptor",Protease,"Primary ac
tive transporter",Lyase,"Cytochrome P450","Protein Kinase","Small molecule receptor (family A GPCR)",Bromodomain,"Nuclear hormone receptor subfamily 1","Peptide receptor (family A GPCR)","Serine prote
ase","ATP-binding cassette","Cytochrome P450 family 19","TK protein kinase group","TKL protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Monoamine receptor","Other protein
 kinase group","STE protein kinase group","AGC protein kinase group","Nuclear hormone receptor subfamily 1 group F","Short peptide receptor (family A GPCR)","Serine protease SC clan","ABCB subfamily",
"CK1 protein kinase group","Cytochrome P450 family 19A","Tyrosine protein kinase Eph family","TKL protein kinase RAF family","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase VEGFR family"
,"Tyrosine protein kinase PDGFR family","CMGC protein kinase MAPK family","Serotonin receptor","CMGC protein kinase CDK family","Other protein kinase AUR family","Tyrosine protein kinase Axl family","
CAMK protein kinase CAMK2 family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Src family","STE protein kinase STE7 family","Tyrosine protein kinase Abl family","STE protein kinase ST
E20 family","Tyrosine protein kinase FGFR family","TKL protein kinase RIPK family","Tyrosine protein kinase Trk family","Other protein kinase ULK family","CAMK protein kinase unique family","TKL prote
in kinase MLK family","Tyrosine protein kinase DDR family","CAMK protein kinase MLCK family","CMGC protein kinase CLK family","Other protein kinase TTK family","AGC protein kinase DMPK family","Tyrosi
ne protein kinase Tie family","CMGC protein kinase DYRK family","TKL protein kinase LISK family","CMGC protein kinase SRPK family","Tyrosine protein kinase Ack family","CMGC protein kinase CDKL family
","Tyrosine protein kinase EGFR family","TKL protein kinase STKR family","AGC protein kinase RSK family","Tyrosine protein kinase Musk family","TKL protein kinase IRAK family","Nuclear hormone recepto
r subfamily 1 group F member 3","Neurotensin receptor","Other protein kinase PLK family","Serine protease S33 family","CK1 protein kinase CK1 family","STE protein kinase STE11 family","Tyrosine protei
n kinase Met family","Tyrosine protein kinase Csk family","Tyrosine protein kinase JakA family","CMGC protein kinase GSK family","Tyrosine protein kinase InsR family","Cytochrome P450 19A1","Melanocor
tin receptor","CAMK protein kinase MNK subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase PCTAIRE","CMGC protein kinase PFTAIRE","CMGC protein kinase CDK8 subfamily","STE protein kina
se SLK subfamily","TKL protein kinase HH498 subfamily","STE protein kinase TAO subfamily","AGC protein kinase CRIK subfamily","CMGC protein kinase CDK7 subfamily","Tyrosine protein kinase Srm","STE pr
otein kinase MSN subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase KHS subfamily","TKL protein kinase LIMK subfamily","CMGC protein kinase JNK su
bfamily","CMGC protein kinase ERK1","TKL protein kinase STKR Type 2 subfamily","CMGC protein kinase CDK5 subfamily","TKL protein kinase MLK subfamily","AGC protein kinase RSK subfamily","Tyrosine prot
ein kinase SrcA","CMGC protein kinase nmo subfamily","CMGC protein kinase Dyrk2 subfamily","AGC protein kinase p70 subfamily","Other protein kinase PLK2","TKL protein kinase TAK1 subfamily","STE prote
in kinase NinaC subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)","G protein-coupled receptors","Nuclear hormone receptors",Hydrolases,"ATP-binding cassette transporter family","Carbonic an
hydrases","Cytochrome P450","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","5-Hydroxytryptamine receptors","STE: Homologs of ye
ast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","1F. Retinoic acid-related orphans","Neurotensin receptors","ABCB subfamily","CK1: Casein kinase 1",CYP11,CYP1
7,CYP19,"CYP20 and CYP21 families","Melanocortin receptors","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","Mitogen-activated protein kinases (MAP k
inases)","Cyclin-dependent kinase (CDK) family","Other protein kinases","CAMK2 family","STE7 family","STE20 family","CAMK-unique family","Myosin Light Chain Kinase (MLCK) family","CLK family","DMPK fa
mily","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","SRPK family","Cyclin-dependent kinase-like (CDKL) family","RSK family","Casein kinase 1 (CK1) family","Glycogen sy
nthase kinase (GSK) family","Receptor tyrosine kinases (RTKs)","RAF family","MKN subfamily","p38 subfamily","TAIRE subfamily","Aurora kinase (Aur) family","Non-receptor tyrosine kinases (nRTKs)","CDK8
 subfamily","SLK subfamily","Receptor interacting protein kinase (RIPK) family","Unc-51-like kinase (ULK) family","Mixed Lineage Kinase (MLK) family","TAO subfamily","TTK family","Erk7 subfamily","Oth
er DMPK family kinases","CDK7 subfamily","MSN subfamily","CDK1 subfamily","HIPK subfamily","KHS subfamily","LIM domain kinase (LISK) family","JNK subfamily","ERK subfamily","Receptor serine/threonine 
kinase (RSTK) family","CDK5 subfamily","RSK subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","nmo subfamily","Dyrk2 subfamily","p70 subfamily","Polo-like kinase (PLK) family","NinaC
 subfamily","STE20 subfamily","GSK subfamily","Type XIII RTKs: Ephrin receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 r
eceptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type XIV RTKs: RET","Src family","Abl family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type VII RT
Ks: Neurotrophin receptor/Trk family","HH498 subfamily","Type XVI RTKs: DDR (collagen receptor) family","Type XII RTKs: TIE family of angiopoietin receptors","LIMK subfamily","Ack family","Type I RTKs
: ErbB (epidermal growth factor) receptor family","Type II receptor serine/threonine kinases","MLK subfamily","Type IX RTKs: MuSK","TAK1 subfamily","Type X RTKs: HGF (hepatocyte growth factor) recepto
r family","Csk family","Janus kinase (JakA) family","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction",Disease,"Gene expression (Transcription)","Neuronal System","Immune System","Extracellular matrix organization","Cellular responses to external stimuli",
"Cell Cycle",Metabolism,Hemostasis,"Nervous system development","MAPK family signaling cascades","Signaling by Receptor Tyrosine Kinases","Infectious disease","RNA Polymerase II Transcription","Transm
ission across Chemical Synapses","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System","Intracellular signaling by second messengers","Non-integrin 
membrane-ECM interactions","Signaling by Rho GTPases","Signaling by Non-Receptor Tyrosine Kinases","Cellular responses to stress",Mitotic,"Metabolism of lipids","Signaling by GPCR","ECM proteoglycans"
,"Cell surface interactions at the vascular wall","Signaling by WNT","MTOR signalling","Cytokine Signaling in Immune system","Reversible hydration of carbon dioxide","Biological oxidations","Axon guid
ance","MAPK1/MAPK3 signaling","Signaling by VEGF","Signaling by Insulin receptor","Signaling by NTRKs","Leishmania infection","Generic Transcription Pathway","Neurotransmitter receptors and postsynapt
ic signal transmission","Oncogenic MAPK signaling","Signaling by NOTCH1 in Cancer","Signaling by KIT in disease","Toll-like Receptor Cascades","PIP3 activates AKT signaling","Signaling by FGFR in dise
ase","HIV Infection","Neutrophil degranulation","RHO GTPase Effectors","Signaling by PTK6","Cellular Senescence","M Phase","Regulation of lipid metabolism by PPARalpha","Signaling by FGFR","GPCR downs
tream signalling","Signaling by TGF-beta Receptor Complex in Cancer","GPCR ligand binding","Signaling by PDGFR in disease","Beta-catenin independent WNT signaling","mTORC1-mediated signalling","Biosyn
thesis of specialized proresolving mediators (SPMs)","Mitotic G2-G2/M phases","Metabolism of steroids","Signaling by WNT in cancer","Signaling by Interleukins","SARS-CoV Infections","Phase I - Functio
nalization of compounds","EPH-Ephrin signaling","RAF/MAP kinase cascade","VEGF ligand-receptor interactions","Insulin receptor signalling cascade","Signaling by NTRK1 (TRKA)","Leishmania parasite grow
th and survival","Transcriptional Regulation by VENTX","Transcriptional Regulation by TP53","VEGFA-VEGFR2 Pathway","Activation of NMDA receptors and postsynaptic events","RET signaling","Signaling by 
RAS mutants","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Drug resistance of KIT mutants","Toll Like Receptor 5 (TLR5) Cascade","PTEN Regulation","Signaling by ROBO receptors","Signaling by
 FGFR1 in disease","Host Interactions of HIV factors","Negative regulation of the PI3K/AKT network","Parasite infection","RHO GTPases activate CIT","HIV Life Cycle","PTK6 Down-Regulation","Oxidative S
tress Induced Senescence","Signaling by FGFR2 in disease","Signaling by FGFR3 in disease","Mitotic Metaphase and Anaphase","PPARA activates gene expression","Semaphorin interactions","Signaling by FGF
R4","G alpha (q) signalling events","Loss of Function of SMAD2/3 in Cancer","Class A/1 (Rhodopsin-like receptors)","Drug resistance of PDGFR mutants","Signaling by NTRK3 (TRKC)","Transcriptional regul
ation by RUNX3","Ca2+ pathway","Toll Like Receptor 4 (TLR4) Cascade","Biosynthesis of DHA-derived SPMs","G2/M Transition","Bile acid and bile salt metabolism","Signaling by AMER1 mutants","Interleukin
-2 family signaling","Transcriptional regulation by RUNX1","SARS-CoV-1 Infection","Cytochrome P450 - arranged by substrate type","EPHA-mediated growth cone collapse","Negative regulation of MAPK pathw
ay","VEGF binds to VEGFR leading to receptor dimerization","IRS-mediated signalling","Signalling to ERKs","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of TP53 Activ
ity","Post NMDA receptor activation events","Signalling to ERK5","Signaling downstream of RAS mutants","VEGFR2 mediated cell proliferation","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","D
asatinib-resistant KIT mutants","MyD88 cascade initiated on plasma membrane","Regulation of PTEN stability and activity","Role of ABL in ROBO-SLIT signaling","FGFR1 mutant receptor activation","The ro
le of Nef in HIV-1 replication and disease pathogenesis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Leishmania phagocytosis","Late Phase of HIV Life Cycle","FGFR2 mutant receptor activation","S
ignaling by FGFR3 point mutants in cancer","Mitotic Anaphase","EPHB-mediated forward signaling","Sema4D in semaphorin signaling","Negative regulation of FGFR4 signaling","Gastrin-CREB signalling pathw
ay via PKC and MAPK","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Amine ligand-binding receptors","Imatinib-resistant PDGFR mutants","Activation of TRKA receptors","Activated NTRK3 signals throu
gh PI3K","RUNX3 Regulates Immune Response and Cell Migration","Peptide ligand-binding receptors","MyD88-independent TLR4 cascade","Biosynthesis of maresins","Centrosome maturation","Synthesis of bile 
acids and bile salts","Truncations of AMER1 destabilize the destruction complex","Interleukin-15 signaling","RUNX1 regulates transcription of genes involved in BCR signaling","SARS-CoV-1 Genome Replic
ation and Transcription","Endogenous sterols","Negative feedback regulation of MAPK pathway","PI3K Cascade","Signalling to RAS","ADORA2B mediated anti-inflammatory cytokines production","Prolonged ERK
 activation events","Regulation of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","FCGR3A-mediated IL10 synthesis","MAP kinas
e activation","Signaling by activated point mutants of FGFR1","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated phagocytosis","Transcrip
tion of the HIV genome","Activated point mutants of FGFR2","FGFR3 mutant receptor activation","Separation of Sister Chromatids","Regulation of TP53 Expression and Degradation","Sema4D induced cell mig
ration and growth-cone collapse","Spry regulation of FGF signaling","EGFR Transactivation by Gastrin","Serotonin receptors","Nef and signal transduction","NGF-independant TRKA activation","CD163 media
ting an anti-inflammatory response","TRIF(TICAM1)-mediated TLR4 signaling","Loss of proteins required for interphase microtubule organization from the centrosome","Synthesis of bile acids and bile sal
ts via 7alpha-hydroxycholesterol","Sema4D mediated inhibition of cell attachment and migration","Replication of the SARS-CoV-1 genome","p38MAPK events","ARMS-mediated activation","Ras activation upon 
Ca2+ influx through NMDA receptor","MAPK targets/ Nuclear events mediated by MAP kinases","activated TAK1 mediates p38 MAPK activation","Nef Mediated CD4 Down-regulation","HIV Transcription Elongation
","Signaling by activated point mutants of FGFR3","Regulation of TP53 Degradation","RSK activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Loss of Nlp from mitotic centrosomes
","IKK complex recruitment mediated by RIP1","Activation of the AP-1 family of transcription factors","Tat-mediated elongation of the HIV-1 transcript","ERK/MAPK targets","Formation of HIV-1 elongatio
n complex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
{BRAF,DDR2,FGFR1,FLT1,FLT3,FLT4,KDR,KIT,PDGFRB,RAF1,RET}

> <broad_moa>
{"FLT3 inhibitor","KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","RAF inhibitor","RET tyrosine kinase inhibitor","VEGFR inhibitor"}

> <synonyms>
{SCHEMBL10324287,4-(4-(3-(4-chloro-3-methylphenyl)ureido)phenoxy)-N-methylpicolinamide,4(4(3(4chloro3methylphenyl)ureido)phenoxy)Nmethylpicolinamide,SY-Sorafenib,"Sorafenib    (Nexavar,    BAY43-9006)
"}

> <pdid>
PD003493

> <targets>
{B-Raf,Erk,B-raf,Mek}

> <classes>
{}

> <pubchem_cids>
{59772862}

$$$$
UTKinase_V5
  SciTegic11012413002D

 11 11  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.1996    1.4928    0.0000 Br  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28655

> <plate>
Kinase v5-2

> <well>
D04

> <supplier_cmpd_name>
PTP-1

> <ctcr_id>
6336

> <supplier_cmpd_id>
SY-PTP-1

> <smiles>
Oc1ccc(cc1)C(=O)CBr

> <pd_targets>
{PTPN1}

> <pathway_gtopdb>
{Enzyme,Phosphatase,"Protein Phosphatase","Tyrosine protein phosphatase"}

> <pathway_chembl>
{Enzymes,Phosphatases,"Protein tyrosine phosphatases non-receptor type (PTPN)"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by MECP2","MECP2 regulates neuronal receptors and channels"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{TP,2-BROMO-4'-HYDROXYACETOPHENONE,2BROMO4'HYDROXYACETOPHENONE,2491-38-5,2491385,2-bromo-1-(4-hydroxyphenyl)ethanone,2bromo1(4hydroxyphenyl)ethanone,"4-Hydroxyphenacyl bromide","4Hydroxyphenacyl bromi
de","Ethanone, 2-bromo-1-(4-hydroxyphenyl)-","Ethanone, 2bromo1(4hydroxyphenyl)",2-Bromo-1-(4-hydroxyphenyl)ethan-1-one,2Bromo1(4hydroxyphenyl)ethan1one,"Busan 90",UNII-6H0QU4I6BA,UNII6H0QU4I6BA,alpha
-Bromo-4-hydroxyacetophenone,alphaBromo4hydroxyacetophenone,6H0,T7084,SY-PTP-1,"PTP Inhibitor I",PTP-1}

> <pdid>
PD044329

> <targets>
{PTP,SHP-2,PTP1B}

> <classes>
{}

> <pubchem_cids>
{4964}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1047   -0.0031    0.0000 C   0  0
   -5.8570    1.2946    0.0000 O   0  0
   -5.8532   -1.3040    0.0000 C   0  0
   -7.3336   -1.4470    0.0000 N   0  0
   -7.6399   -2.9146    0.0000 C   0  0
   -8.9363   -3.6692    0.0000 C   0  0
   -8.9310   -5.1692    0.0000 C   0  0
   -7.6294   -5.9146    0.0000 C   0  0
   -6.3330   -5.1600    0.0000 C   0  0
   -6.3382   -3.6601    0.0000 C   0  0
   -5.2275   -2.6532    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9  5  1  0
  9 10  2  0
 10  2  1  0
  7 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 20 21  1  0
 21 13  2  0
M  END
> <name>
UTKinase_V5

> <id>
28656

> <plate>
Kinase v5-2

> <well>
D06

> <supplier_cmpd_name>
D-64406 (PDGFR TK Inbtr 1)

> <ctcr_id>
3325

> <supplier_cmpd_id>
SY-D-64406

> <smiles>
Oc1ccc2[nH]c(cc2c1)C(=O)c3[nH]c4ccccc4c3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"64406 (PDGFR TK INBTR 1",(5-hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanone,(5hydroxy1Hindol2yl)(1Hindol2yl)methanone,CHEMBL7735,"PDGF Receptor Tyrosine Kinase Inhibitor I",(5-Hydroxy-1H-2-indolyl)(
1H-2-indolyl)-methanone,(5Hydroxy1H2indolyl)(1H2indolyl)methanone,249762-62-7,249762627,D-64406,D64406,BDBM6581,SCHEMBL4456469,CHEBI:92486,ZINC24261,Bis(,SY-D-64406,"D-64406 (PDGFR TK Inbtr 1)"}

> <pdid>

> <targets>
{"PDGFR tyrosine kinase"}

> <classes>
{}

> <pubchem_cids>
{5330535}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  1  0            999 V2000
    5.2059   -2.9909    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0  2  0  0  0
    6.4972   -0.7364    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    5.1903    1.5091    0.0000 N   0  0
    3.8939    0.7546    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    2.6030   -2.9977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.1821    3.0099    0.0000 C   0  0
    6.4772    3.7666    0.0000 O   0  0
    3.8787    3.7539    0.0000 C   0  0
    3.8704    5.2547    0.0000 C   0  0
    3.8621    6.7547    0.0000 N   0  0
  2  1  1  1
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 10  1  0
 18 14  2  0
  5 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  3  0
M  END
> <name>
UTKinase_V5

> <id>
28657

> <plate>
Kinase v5-2

> <well>
D08

> <supplier_cmpd_name>
CP690550 (Tofacitinib)

> <ctcr_id>
7729

> <supplier_cmpd_id>
SY-CP690550

> <smiles>
C[C@@H]1CCN(CC1N(C)c2ncnc3[nH]ccc23)C(=O)CC#N

> <pd_targets>
{RPS6KA1,ULK3,CAMK2A,CAMK2D,JAK1,TYK2,JAK3,PKN1,JAK2,ROCK2,RPS6KA6,PRKCD,NUAK2,TNK1,CAMK1,ABL1,MAP4K2,DCLK3,RPS6KA2,FYN,LCK,PKNB,LRRK2,STK3,MKNK2,PKN2,GRK7,DMPK,DCLK1,CAMK1D,RET,ROCK1,BMP2K}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","Other protein kinase group","CAMK protein kinase group","TK protein kinase group","STE protein kinase group","TKL protein kinase group","AGC
 protein kinase RSK family","Other protein kinase ULK family","CAMK protein kinase CAMK2 family","Tyrosine protein kinase JakA family","AGC protein kinase PKN family","AGC protein kinase DMPK family",
"AGC protein kinase PKC family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Ack family","Tyrosine protein kinase Abl family","STE protein kinase STE20 family","CAMK protein kinase DCAM
K1 family","Tyrosine protein kinase Src family","TKL protein kinase LRRK family","CAMK protein kinase MAPKAPK family","AGC protein kinase GRK family","Tyrosine protein kinase Ret family","Other protei
n kinase NAK family","AGC protein kinase RSK subfamily","AGC protein kinase ROCK subfamily","AGC protein kinase PKC delta subfamily","CAMK protein kinase NuaK subfamily","STE protein kinase KHS subfam
ily","Tyrosine protein kinase SrcA","STE protein kinase MST subfamily","CAMK protein kinase MNK subfamily","AGC protein kinase GRK subfamily","AGC protein kinase GEK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast
 Sterile 7","Sterile 11","Sterile 20 kinases","RSK family","Other protein kinases","CAMK2 family","TK: Tyrosine kinase","Protein kinase N (PKN) family","DMPK family","Protein kinase C (PKC) family","C
AMK-like (CAMKL) family","CAMK1 family","STE20 family","DCAMKL family","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","G protein-coupled receptor kinases (GRKs)","RSK sub
family","Unc-51-like kinase (ULK) family","Non-receptor tyrosine kinases (nRTKs)","Rho kinase","Delta subfamily","NuaK subfamily","KHS subfamily","Leucine-rich repeat kinase (LRRK) family","MST subfam
ily","MKN subfamily","Opsin/rhodopsin kinases","GEK subfamily","Receptor tyrosine kinases (RTKs)","Numb-associated kinase (NAK) family","Janus kinase (JakA) family","Ack family","Abl family","Src fami
ly","Type XIV RTKs: RET"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Neuronal System","Cell Cycle","Developmental Biology",Disease,"Muscle contraction","Innate Immune System","Signaling by Hedgehog","Transmission across Chemical 
Synapses","Cytokine Signaling in Immune system","Signaling by Rho GTPases",Mitotic,"Nervous system development","Intracellular signaling by second messengers","Infectious disease","Signaling by Non-Re
ceptor Tyrosine Kinases","Signaling by Hippo","Signaling by GPCR","Cardiac conduction","Toll-like Receptor Cascades","Hedgehog 'on' state","Neurotransmitter receptors and postsynaptic signal transmiss
ion","Interferon Signaling","Signaling by Interleukins","RHO GTPase Effectors","Mitotic G1 phase and G1/S transition","Axon guidance","DAG and IP3 signaling","Leishmania infection","HIV Infection","Si
gnaling by PTK6","GPCR downstream signalling","Ion homeostasis","Toll Like Receptor 5 (TLR5) Cascade","Activation of NMDA receptors and postsynaptic events","Antiviral mechanism by IFN-stimulated gene
s","Interferon alpha/beta signaling","Interleukin-2 family signaling","RHO GTPases activate PKNs","G1 Phase","Semaphorin interactions","CaM pathway","Parasite infection","Host Interactions of HIV fact
ors","PTK6 promotes HIF1A stabilization","G alpha (i) signalling events","RET signaling","MyD88 cascade initiated on plasma membrane","Post NMDA receptor activation events","ISG15 antiviral mechanism"
,"Regulation of IFNA signaling","Interleukin-15 signaling","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Cyclin D associated events in G1","Sema4D 
in semaphorin signaling","Calmodulin induced events","Leishmania phagocytosis","The role of Nef in HIV-1 replication and disease pathogenesis","Visual phototransduction","MAP kinase activation","CREB1
 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Sema4D induced cell migration and growth-cone collapse","Activation of RAC1 downstream of NMDARs","FCGR3A-mediated phagocy
tosis","Nef and signal transduction","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","The phototransduction cascade","MAPK targets/ Nuclear events medi
ated by MAP kinases","Ras activation upon Ca2+ influx through NMDA receptor","RSK activation","Nef Mediated CD4 Down-regulation",Inactivation,"recovery and regulation of the phototransduction cascade"
,"CREB phosphorylation"}

> <broad_targets>
{JAK1,JAK2,JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{C16H20N6O,SCHEMBL11949309,SYN1032,AS-16199,AS16199,SY-Tofacitinib,"CP690550 (Tofacitinib)"}

> <pdid>
PD003234

> <targets>
{JAK3}

> <classes>
{}

> <pubchem_cids>
{25009830}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    3.8964    0.7545    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.4469    5.2298    0.0000 C   0  0
    2.9152    5.5365    0.0000 C   0  0
    3.5301    6.9047    0.0000 C   0  0
    3.6607    4.2349    0.0000 N   0  0
    2.6531    3.1237    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
    0.0000   -4.5008    0.0000 N   0  0
    5.2003   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    7.7985   -1.4932    0.0000 C   0  0
    7.7985   -2.9932    0.0000 C   0  0
    9.0976   -3.7432    0.0000 F   0  0
    6.4995   -3.7432    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13  8  2  0
  6 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  2  0
 17  4  1  0
 17 18  1  0
 18 19  3  0
  2 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28658

> <plate>
Kinase v5-2

> <well>
D10

> <supplier_cmpd_name>
AZ-960

> <ctcr_id>
5030

> <supplier_cmpd_id>
SY-AZ-960

> <smiles>
CC(Nc1nc(Nc2cc(C)[nH]n2)c(F)cc1C#N)c3ccc(F)cc3

> <pd_targets>
{JAK3,JAK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase JakA family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Immune System","Cell Cycle","Cytokine Signaling in Immune system",Mitotic,"Signaling by Interleukins","Mitotic G1 phase and G1/S transition","Interleukin-2 family signaling","G1 Phase","Interleukin-
15 signaling","Cyclin D associated events in G1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Z96,SCHEMBL14840366,HMS3244K15,HMS3244K16,HMS3244L15,HMS3655L10,NCGC00389417-01,NCGC0038941701,AK471620,FT-0774424,FT0774424,SY-AZ-960,S2214,AZ-960,"AZ 960"}

> <pdid>
PD010824

> <targets>
{JAKS,JAK}

> <classes>
{JAK/STAT}

> <pubchem_cids>
{56965903}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    3.9015    0.7475    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    6.4924   -3.7566    0.0000 N   0  0
    3.8943   -3.7525    0.0000 N   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 S   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1047    0.0000    0.0000 C   0  0
   -5.8543   -1.2993    0.0000 C   0  0
   -6.6047   -0.0008    0.0000 C   0  0
   -5.8555    1.2985    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 12  1  0
 11 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 18  1  0
 22 23  2  0
 23  9  1  0
 20 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28659

> <plate>
Kinase v5-2

> <well>
D12

> <supplier_cmpd_name>
GNE-490

> <ctcr_id>
5860

> <supplier_cmpd_id>
SY-GNE-490

> <smiles>
Cc1nc(N)ncc1c2nc(N3CCOCC3)c4sc(cc4n2)C(C)(C)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NE49,GNE-490,GNE490,1033739-92-2,1033739922,CHEMBL1085178,SCHEMBL4447773,"GNE490;GNE 490",SYN1114,HMS3244F04,HMS3244F08,HMS3244F12,BCP21623,EX-A1841,EXA1841,BDBM50312605,ZINC49112903,NCGC00345837-01,
NCGC0034583701,NCGC00345837-02,NCGC0034583702,AS-16258,AS16258,DB-098031,DB098031,SY-GNE-490}

> <pdid>

> <targets>
{"pan PI3K"}

> <classes>
{}

> <pubchem_cids>
{46180666}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
    4.9133   -1.1373    0.0000 Cl  0  0
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 N   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -6.4939    0.7411    0.0000 O   0  0
   -6.4894   -0.7597    0.0000 C   0  0
   -7.7864   -1.5148    0.0000 C   0  0
   -9.0879   -0.7692    0.0000 N   0  0
   -7.7819   -3.0157    0.0000 C   0  0
   -9.0789   -3.7708    0.0000 C   0  0
   -9.0766   -5.2708    0.0000 C   0  0
  -10.3744   -6.0229    0.0000 C   0  0
  -11.6746   -5.2750    0.0000 C   0  0
  -11.6770   -3.7750    0.0000 C   0  0
  -10.3792   -3.0229    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  3  1  0
 11  6  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 16 28  2  0
 28 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28660

> <plate>
Kinase v5-2

> <well>
D14

> <supplier_cmpd_name>
A-674563

> <ctcr_id>
2968

> <supplier_cmpd_id>
SY-A674563

> <smiles>
Cl.Cc1n[nH]c2ccc(cc12)c3cncc(OCC(N)Cc4ccccc4)c3

> <pd_targets>
{PRKCD,AKT1,JAK3,CDKL3,DAPK3,CDK18,GSK3A,PAK6,MAP3K19,STK33,CDK15,MAP4K4,KIT,PRKX,HIPK3,PRKD3,PRKG1,PRPF4B,FLT3,DMPK,DYRK1B,PRKCE,PHKG1,PKN2,PRKG2,CAMKK2,DAPK2,TNIK,CDC42BPG,ROCK1,CDK17,PIM3,RPS6KA4,A
KT2,SRPK1,CDK13,PAK5,HIPK4,LRRK2,MAPK1,CHEK2,MYLK4,PIP5K1A,CAMK2B,CAMK4,CDK7,CSNK2A1,PRKACA,PIP4K2B,CSNK1G1,CAMKK1,DYRK1A,MYLK3,CDKL2,CLK3,STK17B,CDK16,STK3,SGK3,ULK2,CDK19,TAOK2,TAOK3,MKNK2,CSNK1G3,S
TK17A,AKT3,AAK1,IRAK4,SRC,GSK3B,CDK2,PRKACB,PRKACG,KCNH2,CLK1,PAK4,MINK1,PAK2,PIM1,EIF2AK2,DYRK2,CDC42BPA,RIOK3,CAMK1D,HIPK1,CHEK1,MAPKAPK2,AURKC,CAMK2D,MAP2K3,CDKL5,RPS6KB1,ULK1,HIPK2,CSNK1D,GRK7,CAM
K2G,GRK4,PRKCQ,SRPK3,LATS2,MELK,CILK1,PRKCG,CSNK1G2,NUAK2,CSNK1A1L,MAP3K7,DAPK1,CDC42BPB,PRKCH,PIM2,BMP2K,RPS6KA3,LATS1,GAK,VRK2,CIT,CDK14,RIOK2,CSNK2A2,CSNK2B,PHKG2,CDK3,CSNK1A1,CSNK1E,PAK1,RET,TAOK1
,MYLK,MAPK15,CAMK2A,SRPK2,CDK8,CDK9,IRAK1,PI4KB,CLK4,RIOK1,PKN1,CLK2,MAP4K2,RPS6KA5}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Voltage-gated ion channel",Transferase,"Protein Kinase","Potassium channels","AGC protein kinase group","TK protein kinase group","CMGC protein kinase group","CAMK protei
n kinase group","STE protein kinase group","Other protein kinase group","TKL protein kinase group","CK1 protein kinase group","Voltage-gated potassium channel","Atypical protein kinase group","AGC pro
tein kinase PKC family","AGC protein kinase AKT family","Tyrosine protein kinase JakA family","CMGC protein kinase CDKL family","CAMK protein kinase DAPK family","CMGC protein kinase CDK family","CMGC
 protein kinase GSK family","STE protein kinase STE20 family","STE protein kinase STE11 family","CAMK protein kinase unique family","Tyrosine protein kinase PDGFR family","AGC protein kinase PKA famil
y","CMGC protein kinase DYRK family","CAMK protein kinase PKD family","AGC protein kinase PKG family","AGC protein kinase DMPK family","CAMK protein kinase PHk family","AGC protein kinase PKN family",
"Other protein kinase CAMKK family","CAMK protein kinase PIM family","AGC protein kinase RSK family","CMGC protein kinase SRPK family","TKL protein kinase LRRK family","CMGC protein kinase MAPK family
","CAMK protein kinase RAD53 family","CAMK protein kinase MLCK family","CAMK protein kinase CAMK2 family","CAMK protein kinase CAMK1 family","Other protein kinase CK2 family","CK1 protein kinase CK1 f
amily","CMGC protein kinase CLK family","AGC protein kinase SGK family","Other protein kinase ULK family","CAMK protein kinase MAPKAPK family","Other protein kinase NAK family","TKL protein kinase IRA
K family","Tyrosine protein kinase Src family","Other protein kinase PEK family","Atypical protein kinase RIO family","Other protein kinase AUR family","STE protein kinase STE7 family","AGC protein ki
nase GRK family","AGC protein kinase NDR family","CMGC protein kinase RCK family","TKL protein kinase MLK family","Tyrosine protein kinase Ret family","AGC protein kinase PKC delta subfamily","CMGC pr
otein kinase PCTAIRE","STE protein kinase PAKB subfamily","CMGC protein kinase PFTAIRE","STE protein kinase MSN subfamily","CMGC protein kinase HIPK subfamily","AGC protein kinase GEK subfamily","CMGC
 protein kinase Dyrk1 subfamily","AGC protein kinase PKC eta subfamily","Other protein kinase Meta subfamily","AGC protein kinase ROCK subfamily","AGC protein kinase MSK subfamily","CMGC protein kinas
e ERK1","CMGC protein kinase CDK7 subfamily","CMGC protein kinase TAIRE subfamily","STE protein kinase MST subfamily","CMGC protein kinase CDK8 subfamily","STE protein kinase TAO subfamily","CAMK prot
ein kinase MNK subfamily","CK1 protein kinase CK1-g","CMGC protein kinase CDC2 subfamily","STE protein kinase PAKA subfamily","Other protein kinase PKR","CMGC protein kinase Dyrk2 subfamily","Atypical
 protein kinase RIO3 subfamily","CAMK protein kinase CHK1 subfamily","CAMK protein kinase MAPKAPK subfamily","AGC protein kinase p70 subfamily","AGC protein kinase GRK subfamily","CAMK protein kinase 
MELK subfamily","CMGC protein kinase MAK","AGC protein kinase PKC alpha subfamily","CAMK protein kinase NuaK subfamily","CK1 protein kinase CK1-a","TKL protein kinase TAK1 subfamily","AGC protein kina
se RSK subfamily","AGC protein kinase CRIK subfamily","Atypical protein kinase RIO2 subfamily","CMGC protein kinase CDK9 subfamily","Atypical protein kinase RIO1 subfamily","STE protein kinase KHS sub
family"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Catalytic receptors","Voltage-gated ion channels","AGC: Containing PKA",PKG,"PKC families","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3
,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Lipid modifying kinases","CK1: Casein kinase 1","Potassium ch
annels",Atypical,"Protein kinase C (PKC) family","Akt (Protein kinase B","PKB) family","TK: Tyrosine kinase","Cyclin-dependent kinase-like (CDKL) family","Death-associated kinase (DAPK) family","Cycli
n-dependent kinase (CDK) family","Glycogen synthase kinase (GSK) family","STE20 family","CAMK-unique family","Protein kinase A (PKA) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated ki
nase (DYRK) family","Protein kinase D (PKD) family","Protein kinase G (PKG) family","DMPK family","Phosphorylase kinase (PHK) family","Protein kinase N (PKN) family","Other protein kinases","PIM famil
y","RSK family","SRPK family","TKL: Tyrosine kinase-like","Mitogen-activated protein kinases (MAP kinases)","CAMK-like (CAMKL) family","Myosin Light Chain Kinase (MLCK) family","Type I PIP kinases (1-
phosphatidylinositol-4-phosphate 5-kinase family)","CAMK2 family","CAMK1 family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Casein kinase 1 (CK1) family","CLK family",
"SGK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Voltage-gated potassium channels","RIO family","STE7 family","G protein-coupled receptor kinases (GRKs)","NDR family","RCK family","Vacci
na related kinase (VRK) family","1-phosphatidylinositol 4-kinase family","Delta subfamily","Non-receptor tyrosine kinases (nRTKs)","TAIRE subfamily","GSK subfamily","PAKB subfamily","STE20 subfamily",
"MSN subfamily","Receptor tyrosine kinases (RTKs)","HIPK subfamily","PRP4 subfamily","GEK subfamily","Dyrk1 subfamily","Eta subfamily","CAMKK family","Rho kinase","MSK subfamily","CRK7 subfamily","Leu
cine-rich repeat kinase (LRRK) family","ERK subfamily","CHK1 subfamily","CDK7 subfamily","Casein kinase 2 (CK2) family","MST subfamily","Unc-51-like kinase (ULK) family","CDK8 subfamily","TAO subfamil
y","MKN subfamily","NAK family","Interleukin-1 receptor-associated kinase (IRAK) family","CDK1 subfamily","PAKA subfamily","PEK family","Dyrk2 subfamily","RIO3 subfamily","MAPKAPK subfamily","Aurora k
inase (Aur) family","p70 subfamily","Opsin/rhodopsin kinases","GRK4 subfamily","MELK subfamily","Alpha subfamily","NuaK subfamily","Mixed Lineage Kinase (MLK) family","Numb-associated kinase (NAK) fam
ily","RSK subfamily","Other DMPK family kinases","RIO2 subfamily","Erk7 subfamily","CDK9 subfamily","RIO1 subfamily","KHS subfamily","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 
receptor family","Meta subfamily","Src family","Other PEK family kinases","TAK1 subfamily","Type XIV RTKs: RET"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Immune System","Programmed Cell Death",Disease,"Developmental Biology","Cellular responses to external stimuli",Metabolism,Hemostasis,"Muscle 
contraction","Neuronal System","Cell Cycle","Transport of small molecules","Vesicle-mediated transport","Metabolism of RNA","DNA Repair",Autophagy,"Intracellular signaling by second messengers","RNA P
olymerase II Transcription","Cytokine Signaling in Immune system",Apoptosis,"Infectious disease","Nervous system development","Cellular responses to stress","Diseases of signal transduction by growth 
factor receptors and second messengers","Metabolism of lipids","Platelet homeostasis","Signaling by Receptor Tyrosine Kinases","Cardiac conduction","Innate Immune System","Metabolism of carbohydrates"
,"Signaling by Rho GTPases","MAPK family signaling cascades","Transmission across Chemical Synapses","Signaling by Non-Receptor Tyrosine Kinases","Disorders of Developmental Biology",Mitotic,"Signalin
g by Hippo","Ion channel transport","Membrane Trafficking","rRNA processing","DNA Double-Strand Break Repair","MTOR signalling",Macroautophagy,"Signaling by GPCR","DAG and IP3 signaling","Generic Tran
scription Pathway","Signaling by Interleukins","Caspase activation via extrinsic apoptotic signalling pathway","SARS-CoV Infections","Axon guidance","Cellular Senescence","Signaling by KIT in disease"
,"Leishmania infection","Sphingolipid metabolism","Nitric oxide stimulates guanylate cyclase","Signaling by Insulin receptor","Ion homeostasis","Fcgamma receptor (FCGR) dependent phagocytosis","Glycog
en metabolism","RHO GTPase Effectors","MAPK1/MAPK3 signaling","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by PTK6","Toll-like Receptor Cascades","Phospholipid metaboli
sm","Disorders of Nervous System Development","HIV Infection","Mitotic G2-G2/M phases","Mitotic G1 phase and G1/S transition","Stimuli-sensing channels","Regulation of lipid metabolism by PPARalpha","
Clathrin-mediated endocytosis","Signaling by NTRKs","Phase 3 - rapid repolarisation","FLT3 signaling in disease","Influenza Infection","rRNA processing in the nucleus and cytosol","Homology Directed R
epair","mTORC1-mediated signalling","Selective autophagy","GPCR downstream signalling","trans-Golgi Network Vesicle Budding","M Phase","Signaling by WNT in cancer","Signaling by NOTCH1 in Cancer","CaM
 pathway","Transcriptional Regulation by TP53","Interleukin-2 family signaling","Caspase activation via Dependence Receptors in the absence of ligand","SARS-CoV-1 Infection","Signaling by ROBO recepto
rs","Oxidative Stress Induced Senescence","Drug resistance of KIT mutants","Leishmania parasite growth and survival","Sphingolipid de novo biosynthesis","cGMP effects","Insulin receptor signalling cas
cade","Role of phospholipids in phagocytosis","Glycogen breakdown (glycogenolysis)","RHO GTPases activate PKNs","RAF/MAP kinase cascade","Activation of NMDA receptors and postsynaptic events","Semapho
rin interactions","L1CAM interactions","PTK6 promotes HIF1A stabilization","Toll Like Receptor 5 (TLR5) Cascade","PI Metabolism","Pervasive developmental disorders","HIV Life Cycle","G2/M Transition",
"G0 and Early G1","PPARA activates gene expression","Cargo recognition for clathrin-mediated endocytosis","Toll Like Receptor 2 (TLR2) Cascade","Signaling by NTRK1 (TRKA)","Host Interactions of HIV fa
ctors","Signaling by FLT3 ITD and TKD mutants","NS1 Mediated Effects on Host Pathways","Major pathway of rRNA processing in the nucleolus and cytosol","HDR through Homologous Recombination (HRR) or Si
ngle Strand Annealing (SSA)",Mitophagy,"G alpha (i) signalling events","Glutamate binding","activation of AMPA receptors and synaptic plasticity","Toll Like Receptor 4 (TLR4) Cascade","G alpha (z) sig
nalling events","Golgi Associated Vesicle Biogenesis","Mitotic Metaphase and Anaphase","RHO GTPases activate CIT","Signaling by AMER1 mutants","EPH-Ephrin signaling","RET signaling","RHO GTPases activ
ate PAKs","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Calmodulin induced events","Regulation of TP53 Activity","Interleukin-15 signaling","SARS-CoV-1 Genome Replication and Transcription",
"Activation of RAC1","Dasatinib-resistant KIT mutants","Anti-inflammatory response favouring Leishmania parasite infection","IRS-mediated signalling","RAS processing","Post NMDA receptor activation ev
ents","Sema4D in semaphorin signaling","Recycling pathway of L1","TP53 Regulates Transcription of DNA Repair Genes","MyD88 cascade initiated on plasma membrane","Synthesis of PIPs at the plasma membra
ne","Loss of function of MECP2 in Rett syndrome","Late Phase of HIV Life Cycle","Centrosome maturation","Toll Like Receptor TLR6:TLR2 Cascade","Signalling to ERKs","The role of Nef in HIV-1 replicatio
n and disease pathogenesis","STAT5 activation downstream of FLT3 ITD mutants","Inhibition of PKR","HDR through Homologous Recombination (HRR)","Receptor Mediated Mitophagy","Visual phototransduction",
"Trafficking of AMPA receptors","MyD88-independent TLR4 cascade","Mitotic Anaphase","Truncations of AMER1 destabilize the destruction complex","EPHB-mediated forward signaling","Constitutive Signaling
 by NOTCH1 HD+PEST Domain Mutants","Synthesis of PIPs at the Golgi membrane","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Regulation of TP53 Expre
ssion and Degradation","Replication of the SARS-CoV-1 genome","ADORA2B mediated anti-inflammatory cytokines production","PI3K Cascade","Activation of AMPK downstream of NMDARs","Sema4D induced cell mi
gration and growth-cone collapse","MAP kinase activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Loss of phosphorylation of MECP2 at T308","Transcription o
f the HIV genome","Regulation of TP53 Activity through Phosphorylation","Loss of proteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Activity through Ace
tylation","Activation of RAC1 downstream of NMDARs","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Signalling to RAS","Nef and signal transduction","Homologous DNA Pairing and Strand Exchang
e","The phototransduction cascade","Trafficking of GluR2-containing AMPA receptors","TRIF(TICAM1)-mediated TLR4 signaling","Nuclear Envelope (NE) Reassembly","PKA-mediated phosphorylation of CREB","Se
paration of Sister Chromatids","Regulation of TP53 Degradation","PKB-mediated events","MAPK targets/ Nuclear events mediated by MAP kinases","Ras activation upon Ca2+ influx through NMDA receptor","HI
V Transcription Elongation","Loss of Nlp from mitotic centrosomes","PI5P Regulates TP53 Acetylation","p38MAPK events","Presynaptic phase of homologous DNA pairing and strand exchange","activated TAK1 
mediates p38 MAPK activation",Inactivation,"recovery and regulation of the phototransduction cascade","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Initiation of Nuclear Envelope (NE
) Reformation","PKA activation","PDE3B signalling","ERK/MAPK targets","Tat-mediated elongation of the HIV-1 transcript","CREB phosphorylation","ERKs are inactivated","Formation of HIV-1 elongation com
plex containing HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{67456,"A-674563 HCl","A674563 HCl",C22H22N4O.HCl,SYN1110,AS-16254,AS16254,SY-A674563,A-674563}

> <pdid>
PD004321

> <targets>
{AKT,CDK,PKA}

> <classes>
{}

> <pubchem_cids>
{91895222}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    0.0038  -10.5176    0.0000 C   0  0
    1.3013   -9.7649    0.0000 N   0  0
    2.6016  -10.5126    0.0000 C   0  0
    1.2991   -8.2640    0.0000 C   0  0
    2.5973   -7.5109    0.0000 C   0  0
    2.5952   -6.0101    0.0000 O   0  0
    3.8934   -5.2570    0.0000 C   0  0
    5.1924   -6.0070    0.0000 C   0  0
    6.4915   -5.2571    0.0000 C   0  0
    6.4915   -3.7571    0.0000 C   0  0
    5.1925   -3.0070    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 O   0  0
    7.7911   -6.0075    0.0000 C   0  0
    7.9313   -7.4881    0.0000 C   0  0
    9.3991   -7.7977    0.0000 N   0  0
   10.1470   -6.4975    0.0000 N   0  0
    9.1416   -5.3843    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 24 25  1  0
 25 16  1  0
  9 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 30 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28661

> <plate>
Kinase v5-2

> <well>
D16

> <supplier_cmpd_name>
SR3677

> <ctcr_id>
5326

> <supplier_cmpd_id>
SY-SR3677

> <smiles>
CN(C)CCOc1cc(ccc1NC(=O)C2COc3ccccc3O2)c4c[nH]nc4

> <pd_targets>
{ROCK1,ROCK2,AKT1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase DMPK family","AGC protein kinase AKT family","AGC protein kinase ROCK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","DMPK family","Akt (Protein kinase B","PKB) family","Rho kinase"}

> <pathway_reactome>
{"Developmental Biology","Gene expression (Transcription)","Nervous system development","RNA Polymerase II Transcription","Axon guidance","Generic Transcription Pathway","Semaphorin interactions","Tra
nscriptional Regulation by TP53","Sema4D in semaphorin signaling","Regulation of TP53 Activity","Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Expression and Degradation"
,"Regulation of TP53 Degradation"}

> <broad_targets>
{ROCK2}

> <broad_moa>
{"rho associated kinase inhibitor"}

> <synonyms>
{1072959-67-1,1072959671,SR3677,SR-3677,"SR 3677","JMC516642 Compound 5",SCHEMBL453528,CHEMBL521179,BDBM25474,DTXSID50648693,SYN1083,HMS3244C09,HMS3244C10,HMS3244D09,BCP01976,EX-A1752,EXA1752,3897AH,A
BP000281,AKOS027422764,CS-1726,CS1726,NCGC00345833-01,NCGC0034583301,NCGC00345833-06,NCGC0034583306,AC-33,AC33,SY-SR3677}

> <pdid>
PD012906

> <targets>
{"ROCK II",Autophagy,ROCK}

> <classes>
{Autophagy,Cell Cycle/DNA Damage,Cytoskeleton,Stem Cell/Wnt,TGF-beta/Smad}

> <pubchem_cids>
{25093235}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
   -7.5015    1.9935    0.0000 C   0  0
   -8.5899    0.9613    0.0000 C   0  0
   -8.2402   -0.4974    0.0000 C   0  0
   -6.8021   -0.9240    0.0000 N   0  0
   -5.7137    0.1083    0.0000 C   0  0
   -6.0634    1.5669    0.0000 C   0  0
   -6.4493   -2.3828    0.0000 C   0  0
   -5.0098   -2.8075    0.0000 C   0  0
   -4.6570   -4.2663    0.0000 O   0  0
   -3.2175   -4.6910    0.0000 C   0  0
   -2.8628   -6.1485    0.0000 C   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.7390    2.9810    0.0000 N   0  0
   -4.2067    3.2905    0.0000 N   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  4  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 16  1  0
 24 19  1  0
 22 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 25  2  0
M  END
> <name>
UTKinase_V5

> <id>
28662

> <plate>
Kinase v5-2

> <well>
D18

> <supplier_cmpd_name>
CC-401

> <ctcr_id>
2339

> <supplier_cmpd_id>
SY-CC-401

> <smiles>
C1CCN(CC1)CCOc2cccc(c2)c3n[nH]c4ccc(cc34)c5[nH]ncn5

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{C40,CC-401,CC401,395104-30-0,395104300,UNII-NOE38VQA1W,UNIINOE38VQA1W,NOE38VQA1W,"3-(3-(2-(1-PIPERIDINYL)ETHOXY)PHENYL)-5-(1H-1,2,4-TRIAZOL-5-YL)-1H-INDAZOLE","3(3(2(1PIPERIDINYL)ETHOXY)PHENYL)5(1H1,
2,4TRIAZOL5YL)1HINDAZOLE","862832-38-0 (free base)","862832380 (free base)","CC 401","3-(3-(2-piperidin-1-ylethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole","3(3(2piperidin1ylethoxy)phenyl)5(1H1,
2,4triazol5yl)1Hindazole",C22H24N6O,CC,SY-CC-401}

> <pdid>

> <targets>
{JNK}

> <classes>
{}

> <pubchem_cids>
{10430360}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.1905    2.6376    0.0000 C   0  0
   -4.6589    2.9478    0.0000 C   0  0
   -5.1253    4.3743    0.0000 C   0  0
   -6.5938    4.6845    0.0000 N   0  0
   -7.0600    6.1102    0.0000 C   0  0
   -7.5957    3.5682    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.1884   -2.6409    0.0000 C   0  0
   -4.5650   -3.1911    0.0000 C   0  0
   -4.4475   -4.6865    0.0000 C   0  0
   -5.5882   -5.6605    0.0000 O   0  0
   -2.9890   -5.0368    0.0000 N   0  0
   -2.2051   -3.7579    0.0000 C   0  0
   -0.7106   -3.6291    0.0000 O   0  0
   -5.8396   -2.3989    0.0000 C   0  0
   -7.1567   -3.0918    0.0000 C   0  0
   -8.2151   -2.0288    0.0000 N   0  0
   -7.5314   -0.6946    0.0000 C   0  0
   -8.0659    0.7069    0.0000 C   0  0
   -7.1194    1.8706    0.0000 C   0  0
   -5.6383    1.6327    0.0000 C   0  0
   -5.1038    0.2312    0.0000 C   0  0
   -6.0503   -0.9325    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
  7 14  1  0
 14 15  2  0
 15 16  1  0
 16  6  1  0
 16 17  2  0
 17  3  1  0
 15 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 18  1  0
 23 24  2  0
 19 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 25  1  0
 33 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28663

> <plate>
Kinase v5-2

> <well>
D20

> <supplier_cmpd_name>
Go6983

> <ctcr_id>
1001

> <supplier_cmpd_id>
SY-Go6983

> <smiles>
COc1ccc2n(CCCN(C)C)cc(c2c1)C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45

> <pd_targets>
{PRKCD,PRKCG,PRKCB,PRKCZ,PRKCA,CACNA1C,CACNB2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Voltage-gated ion channel","Protein Kinase","Voltage-gated calcium channel","AGC protein kinase group","AGC protein kinase PKC family","AGC protein kinase PKC delta subfa
mily","AGC protein kinase PKC alpha subfamily","AGC protein kinase PKC iota subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Protein kinase C (PKC) family","Delta subfamily","Alpha subfamily","Iota subfamily"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System","Cell Cycle","Intracellular signaling by second messengers","Transmission across Chemical Synapses",Mitotic,"Signaling by Nuclear Receptors","Signaling by GPCR
","DAG and IP3 signaling","Neurotransmitter receptors and postsynaptic signal transmission","M Phase","ESR-mediated signaling","GPCR downstream signalling","CaM pathway","Glutamate binding","activatio
n of AMPA receptors and synaptic plasticity","Mitotic Prophase","Extra-nuclear estrogen signaling","G alpha (i) signalling events","Calmodulin induced events","Trafficking of AMPA receptors","Nuclear 
Envelope Breakdown","Estrogen-stimulated signaling through PRKCZ","Visual phototransduction","Trafficking of GluR2-containing AMPA receptors","Depolymerisation of the Nuclear Lamina","The phototransdu
ction cascade",Inactivation,"recovery and regulation of the phototransduction cascade"}

> <broad_targets>
{PRKCA,PRKCB,PRKCD,PRKCG,PRKCZ}

> <broad_moa>
{"protein kinase inhibitor"}

> <synonyms>
{Go6983,Go-6983,"Go 6983","Goe 6983",Go-6893,Go6893,"Go 6893",Goe-6983,Goe6983,"Go 6983;Goe 6983","G? 6983",MFCD04040031,"G&ouml; 6983","Gouml 6983",MLS006011225,CHEMBL261491,GTPL5192,SCHEMBL1680253,C
HEBI:91455,DTXSID60274402,HMS3229E15,HMS3650B11,HMS3651D10,BCP06669,EX-A1221,EXA1221,"EX A1221",ZINC252,T6313,"EMD 365251",SY-Go6983,365251}

> <pdid>
PD010518

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{3499}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  0  0            999 V2000
    9.4468   -3.9308    0.0000 C   0  0
    9.1386   -5.3988    0.0000 N   0  0
   10.1384   -6.5170    0.0000 N   0  0
    9.3839   -7.8135    0.0000 C   0  0
    9.9893   -9.1859    0.0000 C   0  0
    7.9178   -7.4965    0.0000 C   0  0
    7.7850   -6.0152    0.0000 C   0  0
    6.4863   -5.2630    0.0000 C   0  0
    6.4889   -3.7630    0.0000 O   0  0
    5.1851   -6.0107    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.1905    2.6376    0.0000 C   0  0
   -4.6589    2.9478    0.0000 C   0  0
   -5.1253    4.3743    0.0000 C   0  0
   -6.5925    4.6864    0.0000 C   0  0
   -7.0558    6.1131    0.0000 C   0  0
   -6.0520    7.2277    0.0000 C   0  0
   -4.5848    6.9156    0.0000 C   0  0
   -4.1215    5.4889    0.0000 N   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    2.5795   -7.5040    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  4  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 18  1  0
 22 23  1  0
 23 15  2  0
 19 24  1  0
 24 25  2  3
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
 13 32  2  0
 32 33  1  0
 33 34  2  0
 34 11  1  0
 34 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
28664

> <plate>
Kinase v5-2

> <well>
D22

> <supplier_cmpd_name>
AG13958

> <ctcr_id>
6352

> <supplier_cmpd_id>
SY-AG13958

> <smiles>
Cn1nc(C)cc1C(=O)Nc2cc(Nc3ccc4c([nH]nc4c3)C=Cc5ccccn5)ccc2F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{DTXSID20953842,HMS3244C17,HMS3244C18,HMS3244D17,913966-92-4,913966924,DB-079007,DB079007,FT-0740003,FT0740003,FT-0772089,FT0772089,SY-AG13958,AG13958}

> <pdid>

> <targets>
{"VEGFR INHIBITOR"}

> <classes>
{}

> <pubchem_cids>
{56965895}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 20  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.8470    1.0097    0.0000 N   0  0
   -3.5970   -0.2893    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  2  1  0
 16 17  1  0
 17  9  2  0
 17 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28665

> <plate>
Kinase v5-2

> <well>
F04

> <supplier_cmpd_name>
SP600125 (JNK Inhibitor II)

> <ctcr_id>
5328

> <supplier_cmpd_id>
SY-SP600125

> <smiles>
O=C1c2ccccc2c3[nH]nc4cccc1c34

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{MAPK10,MAPK8,MAPK8IP1,MAPK9,TTK}

> <broad_moa>
{"JNK inhibitor"}

> <synonyms>
{129-56-6,129566,"1,9-Pyrazoloanthrone","1,9Pyrazoloanthrone",SP600125,Pyrazolanthrone,"Dibenzo(cd,g)indazol-6(2H)-one","Dibenzo(cd,g)indazol6(2H)one",Pyrazoleanthrone,"SP 600125","Anthra(1,9-cd)pyraz
ol-6(2H)-one","Anthra(1,9cd)pyrazol6(2H)one",SP-600125,"Anthra-1,9-pyrazol-6-none","Anthra1,9pyrazol6none","JNK Inhibitor II",2H-Dibenzo(cd,2HDibenzo(cd,S1460,"EMD 420119",SY-SP600125,1496,EI-305,"SP6
00125 (pyrazolanthrone)",420119,"SP600125 (JNK Inhibitor II)"}

> <pdid>

> <targets>
{"JNK kinases",JNK,Apoptosis,Autophagy,Ferroptosis}

> <classes>
{Apoptosis,Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{8515}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 25  0  0  0  0            999 V2000
    6.0537    5.7632    0.0000 O   0  5
    4.6350    5.2759    0.0000 N   0  3
    3.5040    6.2612    0.0000 O   0  0
    4.3480    3.8028    0.0000 C   0  0
    5.4777    2.8159    0.0000 C   0  0
    5.1878    1.3442    0.0000 C   0  0
    3.7691    0.8603    0.0000 C   0  0
    3.1796   -0.5190    0.0000 N   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.5242    2.0130    0.0000 O   0  0
   -1.6852   -0.3847    0.0000 N   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.5000   -2.8577    0.0000 C   0  0
   -0.7500   -4.1567    0.0000 C   0  0
    0.7500   -4.1567    0.0000 C   0  0
    1.5000   -2.8577    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    2.6395    1.8472    0.0000 C   0  0
    2.9286    3.3180    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20  9  1  0
 20 15  1  0
 10 21  1  0
 21  7  1  0
 21 22  2  0
 22  4  1  0
M  CHG  2   1  -1   2   1
M  END
> <name>
UTKinase_V5

> <id>
28666

> <plate>
Kinase v5-2

> <well>
F06

> <supplier_cmpd_name>
Alsterpaullone, 2-cyethyl

> <ctcr_id>
6930

> <supplier_cmpd_id>
SY-Alsterpaullone

> <smiles>
[O-][N+](=O)c1ccc2[nH]c3c(CC(=O)Nc4ccccc34)c2c1

> <pd_targets>
{CDC7,MARK2,PKN2,CDK5,CDK5R1,GSK3B,GSK3A,MST1R,CDK1,CDK2,NIN,BLK,IKBKB,PRKCD,LYN,FGFR1,MINK1,CDK19,CDK9,CCNB1,CCNB2,CCNB3,PFMRK,PIM1,PLK4,SRC,ABL1,CSF1R,ROCK1,MAP4K5,ROCK2,CSNK1D,BRSK1,MAP4K2,FLT4,PAK
4,PDPK1,MAP4K4,IRAK1,ACVR1,CAMK2D,CDK8,LCK,MAPK1,MARK3,CSNK1G2,PASK,CSNK1G1,MAP3K20,CSNK2A1,RPS6KB1,CHEK2,STK3,CDC42BPA,PHKG2,TSSK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","CAMK protein kinase group","AGC protein kinase group","CMGC protein kinase group","TK protein kinase group","STE protein kinase group","CK
1 protein kinase group","TKL protein kinase group","Other protein kinase CDC7 family","CAMK protein kinase CAMK1 family","AGC protein kinase PKN family","CMGC protein kinase CDK family","CMGC protein 
kinase GSK family","Tyrosine protein kinase Met family","Tyrosine protein kinase Src family","Other protein kinase IKK family","AGC protein kinase PKC family","Tyrosine protein kinase FGFR family","ST
E protein kinase STE20 family","CAMK protein kinase PIM family","Other protein kinase PLK family","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR family","AGC protein kinase DMPK f
amily","CK1 protein kinase CK1 family","Tyrosine protein kinase VEGFR family","AGC protein kinase PDK1 subfamily","TKL protein kinase IRAK family","TKL protein kinase STKR family","CAMK protein kinase
 CAMK2 family","CMGC protein kinase MAPK family","TKL protein kinase MLK family","Other protein kinase CK2 family","AGC protein kinase RSK family","CAMK protein kinase RAD53 family","CAMK protein kina
se PHk family","CAMK protein kinase TSSK family","CAMK protein kinase MARK subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily","AGC protein kinase PKC delta subfamily"
,"STE protein kinase MSN subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase CDK9 subfamily","AGC protein kinase ROCK subfamily","STE protein kinase KHS subfamily","CAMK protein kinas
e BRSK subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR1","CMGC protein kinase ERK1","CAMK protein kinase PASK subfamily","TKL protein kinase MLK subfamily","AGC protein kinase 
p70 subfamily","STE protein kinase MST subfamily","AGC protein kinase GEK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC families","CMGC: Containing CDK",
MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CK1: Casein kinase 1","Other protein kinases","CAMK-like (CAMKL) family","Protein kinase N (PKN) family",
"Glycogen synthase kinase (GSK) family","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","Protein kinase C (PKC) family","STE20 family","PIM family","DMPK family","Casein kinase 1 (CK1) fa
mily","PDK1 family","TKL: Tyrosine kinase-like","CAMK2 family","Mitogen-activated protein kinases (MAP kinases)","RSK family","Phosphorylase kinase (PHK) family","Testis specific kinase (TSSK) family"
,"CDC7 family","MARK subfamily","GSK subfamily","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","CDK5 subfamily","Non-receptor tyrosine kinases (nRTKs)","IKK family","Delta subfamily","MSN subfami
ly","CDK8 subfamily","CDK9 subfamily","Polo-like kinase (PLK) family","Rho kinase","KHS subfamily","BRSK subfamily","PAKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","Receptor 
serine/threonine kinase (RSTK) family","ERK subfamily","PASK subfamily","Mixed Lineage Kinase (MLK) family","Casein kinase 2 (CK2) family","p70 subfamily","CHK1 subfamily","MST subfamily","GEK subfami
ly","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Src family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor
 family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type I receptor serine/threonine kinases","MLK subfamily"}

> <pathway_reactome>
{"Cell Cycle","Signal Transduction",Disease,"Gene expression (Transcription)","Immune System","Cellular responses to external stimuli",Metabolism,"Developmental Biology","Neuronal System",Mitotic,"Sig
naling by Rho GTPases","Infectious disease","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Innate Immune System","Intracellular signaling by second messengers","Diseases o
f signal transduction by growth factor receptors and second messengers","Cellular responses to stress","Metabolism of lipids","Nervous system development","Transmission across Chemical Synapses","MTOR
 signalling","Signaling by Hippo","Metabolism of carbohydrates","Mitotic G1 phase and G1/S transition","RHO GTPase Effectors","SARS-CoV Infections","Signaling by MST1","Regulation of mitotic cell cycl
e","Generic Transcription Pathway","Toll-like Receptor Cascades","DAG and IP3 signaling","Leishmania infection","Signaling by FGFR in disease","Cellular Senescence","Regulation of lipid metabolism by 
PPARalpha","HIV Infection","FLT3 signaling in disease","Mitotic G2-G2/M phases","Signaling by NTRKs","Axon guidance","Signaling by VEGF","Neurotransmitter receptors and postsynaptic signal transmissio
n","Signaling by NOTCH1 in Cancer","Oncogenic MAPK signaling","Sphingolipid metabolism","mTORC1-mediated signalling","Glycogen metabolism","G1/S Transition","RHO GTPases activate PKNs","SARS-CoV-1 Inf
ection","APC/C-mediated degradation of cell cycle proteins","Transcriptional Regulation by TP53","Transcriptional regulation by RUNX1","Toll Like Receptor 4 (TLR4) Cascade","CaM pathway","Leishmania p
arasite growth and survival","Signaling by FGFR1 in disease","Oxidative Stress Induced Senescence","PPARA activates gene expression","HIV Life Cycle","Signaling by FLT3 ITD and TKD mutants","G2/M Tran
sition","Signaling by NTRK1 (TRKA)","Parasite infection","Transcriptional Regulation by VENTX","Semaphorin interactions","VEGF ligand-receptor interactions","Signaling by ROBO receptors","Toll Like Re
ceptor 5 (TLR5) Cascade","Activation of NMDA receptors and postsynaptic events","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Host Interactions of HIV factors","Signaling by RAS mutants","Sp
hingolipid de novo biosynthesis","Glycogen breakdown (glycogenolysis)","Activation of the pre-replicative complex","SARS-CoV-1 Genome Replication and Transcription","Activation of APC/C and APC/C:Cdc2
0 mediated degradation of mitotic proteins","Regulation of TP53 Activity","RUNX1 regulates transcription of genes involved in BCR signaling","MyD88-independent TLR4 cascade","Calmodulin induced events
","Anti-inflammatory response favouring Leishmania parasite infection","FGFR1 mutant receptor activation","Late Phase of HIV Life Cycle","STAT5 activation downstream of FLT3 ITD mutants","Centrosome m
aturation","Signalling to ERKs","Leishmania phagocytosis","Sema4D in semaphorin signaling","VEGF binds to VEGFR leading to receptor dimerization","Activation of RAC1","MyD88 cascade initiated on plasm
a membrane","Post NMDA receptor activation events","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","The role of Nef in HIV-1 replication and disease pathogenesis","Signaling downstream of RA
S mutants","Replication of the SARS-CoV-1 genome","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Expression and Degradation","Regulation of TP53 Activity through Phosphoryl
ation","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3A-mediated IL10 synthesis","Signaling by activated point mutants of FGFR1","Transcription of the HIV genome","Loss of proteins required for interpha
se microtubule organization from the centrosome","Signalling to RAS","FCGR3A-mediated phagocytosis","Sema4D induced cell migration and growth-cone collapse","MAP kinase activation","CREB1 phosphorylat
ion through NMDA receptor-mediated activation of RAS signaling","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","APC:Cdc20 mediated degradation of cell
 cycle proteins prior to satisfation of the cell cycle checkpoint","Regulation of TP53 Degradation","IKK complex recruitment mediated by RIP1","HIV Transcription Elongation","Loss of Nlp from mitotic 
centrosomes","p38MAPK events","activated TAK1 mediates p38 MAPK activation","Ras activation upon Ca2+ influx through NMDA receptor","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events med
iated by MAP kinases","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-mediated elongation of the HIV-1 transcript","ERK/MAPK targets","Formation of HIV-1 elongation complex containing HIV-
1 Tat","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{alsterpaullone,237430-03-4,237430034,9-Nitropaullone,9Nitropaullone,"7,12-Dihydro-9-nitroindolo(3,2-d)(1)benzazepin-6(5H)-one","7,12Dihydro9nitroindolo(3,2d)(1)benzazepin6(5H)one","NSC 705701",NSC-70
5701,NSC705701,CHEMBL50894,MLS002702475,"9-Nitro-7,12-dihydroindolo(3,2-d)(1)benzazepin-6(5H)-one","9Nitro7,12dihydroindolo(3,2d)(1)benzazepin6(5H)one",MFCD02683579,9-Nitro-7,9Nitro7,12-dih,12dih,"EMD
 126870",SY-Alsterpaullone,126870,"Alsterpaullone, 2-cyethyl"}

> <pdid>
PD006558

> <targets>
{}

> <classes>
{}

> <pubchem_cids>
{5005498}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 22  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 C   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 C   0  0
    3.8975   -2.2510    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -1.3101    6.7502    0.0000 N   0  0
   -2.6039    2.9994    0.0000 C   0  0
   -2.6039    1.4994    0.0000 N   0  0
   -3.9032    3.7490    0.0000 S   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.5988   -1.5004    0.0000 C   0  0
   -3.8983   -0.7513    0.0000 C   0  0
   -2.5983   -3.0004    0.0000 C   0  0
   -3.8975   -2.2510    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  1  0
 10 11  3  0
  9 12  2  0
 12 13  1  0
 12 14  1  0
  7 15  1  0
 15 16  2  3
 16 17  1  0
 17  5  1  0
 17 18  2  0
 16 19  1  0
 19 20  1  0
 19 21  1  0
 19 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28667

> <plate>
Kinase v5-2

> <well>
F08

> <supplier_cmpd_name>
AG879

> <ctcr_id>
7743

> <supplier_cmpd_id>
SY-AG879

> <smiles>
CC(C)(C)C1=CC(=C\C(C#N)=C(/N)S)C=C(C1=O)C(C)(C)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{AG879,SY-AG879}

> <pdid>
PD015793

> <targets>
{PTK}

> <classes>
{}

> <pubchem_cids>
{5353385}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -6.4842    5.2590    0.0000 Br  0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17 11  1  0
  9 18  2  0
 18  5  1  0
 18 19  1  0
 19 20  2  0
 20  3  1  0
 20 21  1  0
 21 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28668

> <plate>
Kinase v5-2

> <well>
F10

> <supplier_cmpd_name>
AG1517 (PD153035)

> <ctcr_id>
3007

> <supplier_cmpd_id>
SY-AG1517

> <smiles>
COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC

> <pd_targets>
{ABL1,ABL2,MAPT,EGFR,MAPK1,KDM4E,ALOX15,LEF,BLM,HPGD,NFKB1,HSD17B10,PMP22,CYP3A4,GMNN,FBP1,PKMYT1,LMNA,RAF1,HIF1A,CYP2D6,CYP1A2,MAPK14,CHRM1,FFP,GLA,TP53,KMT2A,MEN1,ALDH1A1,MKNK1,SRC,LCK,KDR,EPHB2,TSH
R,ERBB2,CYP2C19,MAPK11,MAPK12,MAPK13,ALD,RORC,CDK1,ABL,ERBB4,CYP2C9,PDGFRB,ABCG2,GAK}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Epigenetic regulator","Unclassified protein","Other nuclear protein","Transcription factor","Membrane receptor",Kinase,Eraser,Oxidoreductase,Protease,"Cytochrome P45
0","Family A G protein-coupled receptor",Transferase,Hydrolase,Reader,"Protein Kinase","Lysine demethylase","Metallo protease","Cytochrome P450 family 3","Cytochrome P450 family 2","Cytochrome P450 fa
mily 1","Small molecule receptor (family A GPCR)",Bromodomain,"TK protein kinase group","CMGC protein kinase group","Jumonji domain-containing","Metallo protease MAE clan","Cytochrome P450 family 3A",
"Other protein kinase group","TKL protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 1A","Monoamine receptor","CAMK protein kinase group","Tyrosine protein kinase Abl family","T
yrosine protein kinase EGFR family","CMGC protein kinase MAPK family","Metallo protease M34 family","Cytochrome P450 3A4","Other protein kinase WEE family","TKL protein kinase RAF family","Cytochrome 
P450 2D6","Cytochrome P450 1A1","Acetylcholine receptor","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Src family","CMGC protein kinase ERK1","CMGC protein kinase p38 subfamily","CAMK 
protein kinase MNK subfamily",Transporter,"Nuclear receptor","Primary active transporter","Peptide receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","ATP-binding cassette","Glycohormone
 receptor","Cytochrome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","ABCG subfamily","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Eph family","Cytochrome P450 2C19
","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase CDK family","Cytochrome P450 2C9","Tyrosine protein kinase PDGFR family","Other protein kinase NAK family","CMGC protein 
kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","G protein-coupled receptors","Receptor kinases","CMGC: Containing
 CDK",MAPK,GSK3,"CLK families","1.14.11.- Histone demethylases",Lipoxygenases,"Prostaglandin synthases","CYP3 family","CYP2 family: drug metabolising subset","CYP1 family","Acetylcholine receptors (mu
scarinic)","CAMK: Calcium/calmodulin-dependent protein kinases","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Other protein kinases","TKL: Tyrosine kinase-like","MAPK-Activa
ted Protein Kinase (MAPKAPK) family","Receptor tyrosine kinases (RTKs)","ERK subfamily","WEE family","RAF family","p38 subfamily","MKN subfamily","Non-receptor tyrosine kinases (nRTKs)","Type I RTKs: 
ErbB (epidermal growth factor) receptor family","Src family",Transporters,"Nuclear hormone receptors","ATP-binding cassette transporter family","Glycoprotein hormone receptors","1F. Retinoic acid-rela
ted orphans","ABCG subfamily","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","Numb-associated kinase (NAK) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","T
ype XIII RTKs: Ephrin receptor family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Neuronal System","Signal Transduction","Immune System",Metabolism,Disease,"DNA Repair","Developmental Biology","Cell Cycle","Cellular responses to external stimuli","Transmission across Chemical Syn
apses","Signaling by GPCR","Innate Immune System","Metabolism of lipids","Infectious disease","DNA Double-Strand Break Repair","Cytokine Signaling in Immune system","Metabolism of amino acids and deri
vatives","Nervous system development",Mitotic,"Metabolism of carbohydrates","MAPK family signaling cascades","Cellular responses to stress","Biological oxidations","Cell Cycle Checkpoints","Signaling 
by Receptor Tyrosine Kinases","Neurotransmitter receptors and postsynaptic signal transmission","GPCR downstream signalling","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving med
iators (SPMs)","Uptake and actions of bacterial toxins","Homology Directed Repair","Signaling by Interleukins","Branched-chain amino acid catabolism","EGR2 and SOX10-mediated initiation of Schwann cel
l myelination","Mitotic G1 phase and G1/S transition","Glucose metabolism","Mitotic G2-G2/M phases","M Phase","MAPK1/MAPK3 signaling","Cellular response to hypoxia","Phase I - Functionalization of com
pounds","GPCR ligand binding","Sphingolipid metabolism","G1/S DNA Damage Checkpoints","Signaling by FGFR","Signaling by NTRKs","HIV Infection","Activation of NMDA receptors and postsynaptic events","G
 alpha (q) signalling events","Toll Like Receptor 5 (TLR5) Cascade","Biosynthesis of DPA-derived SPMs","Uptake and function of anthrax toxins","HDR through Homologous Recombination (HRR) or Single Str
and Annealing (SSA)","Biosynthesis of DHA-derived SPMs","Interleukin-1 family signaling","G1/S Transition",Gluconeogenesis,"G2/M Transition","Mitotic Metaphase and Anaphase","RAF/MAP kinase cascade","
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Cytochrome P450 - arranged by substrate type","Class A/1 (Rhodopsin-like receptors)","Glycosphingolipid metabolism","p53-Depe
ndent G1/S DNA damage checkpoint","Ethanol oxidation","Signaling by FGFR4","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Post NMDA receptor activation events","Gastrin-CREB signallin
g pathway via PKC and MAPK","MyD88 cascade initiated on plasma membrane","Biosynthesis of DPAn-3 SPMs","HDR through Homologous Recombination (HRR)","Biosynthesis of D-series resolvins","Interleukin-1 
signaling","Biosynthesis of maresins","Activation of the pre-replicative complex","Cyclin A/B1/B2 associated events during G2/M transition","Mitotic Anaphase","Negative regulation of MAPK pathway",Xen
obiotics,"Amine ligand-binding receptors","p53-Dependent G1 DNA Damage Response","Negative regulation of FGFR4 signaling","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathoge
nesis","Activation of AMPK downstream of NMDARs","EGFR Transactivation by Gastrin","MAP kinase activation","Biosynthesis of DPAn-3-derived protectins and resolvins","Homologous DNA Pairing and Strand 
Exchange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Biosynthesis of maresin-like SPMs","Nuclear Envelope (NE) Reassembly","Negative feedback regulation of MAPK pathway","CYP2E1 reactions","Aromati
c amines can be N-hydroxylated or N-dealkylated by CYP1A2","Muscarinic acetylcholine receptors","Stabilization of p53","Spry regulation of FGF signaling","Signalling to RAS","Nef-mediates down modulat
ion of cell surface receptors by recruiting them to clathrin adapters","MAPK targets/ Nuclear events mediated by MAP kinases","Presynaptic phase of homologous DNA pairing and strand exchange","Initiat
ion of Nuclear Envelope (NE) Reformation","Autodegradation of the E3 ubiquitin ligase COP1","p38MAPK events","Nef Mediated CD4 Down-regulation","ERK/MAPK targets","Activation of the AP-1 family of tra
nscription factors","ERKs are inactivated","Gene expression (Transcription)","Vesicle-mediated transport","RNA Polymerase II Transcription","Intracellular signaling by second messengers","Abacavir tra
nsport and metabolism","Membrane Trafficking","Signaling by VEGF","Axon guidance","Leishmania infection","Generic Transcription Pathway","Regulation of mitotic cell cycle","PIP3 activates AKT signalin
g","Abacavir transmembrane transport","trans-Golgi Network Vesicle Budding","VEGFA-VEGFR2 Pathway","EPH-Ephrin signaling","Leishmania parasite growth and survival","Semaphorin interactions","Transcrip
tional regulation by RUNX3","APC/C-mediated degradation of cell cycle proteins","Parasite infection","Negative regulation of the PI3K/AKT network","Golgi Associated Vesicle Biogenesis","VEGFR2 mediate
d cell proliferation","EPHB-mediated forward signaling","Anti-inflammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","RUNX3 Regulates Immune Response and Cell 
Migration","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Leishmania phagocytosis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","ADORA2B mediated anti-inflammatory
 cytokines production","Sema4D induced cell migration and growth-cone collapse","APC/C:Cdc20 mediated degradation of mitotic proteins","Long-term potentiation","FCGR3A-mediated phagocytosis","APC:Cdc2
0 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{EGFR,MAPK14}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{153436-54-5,153436545,"N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine","N(3bromophenyl)6,7dimethoxyquinazolin4amine",PD153035,PD-153035,"pd 153035",UNII-TC62B68RSL,UNIITC62B68RSL,"4-(3-BROMOANILIN
O)-6,7-DIMETHOXYQUINAZOLINE","4(3BROMOANILINO)6,7DIMETHOXYQUINAZOLINE",AG-1517,AG1517,"SU 5271","4-(3-bromophenylamino)-6,7-dimethoxyquinazoline","4(3bromophenylamino)6,7dimethoxyquinazoline","AG 1517
",NSC-6693,NSC6693,T2041,T2047,T1761,T2034,SY-AG1517,AG-1478,"PD153035 hydrochloride",AG-1557,"AG1517 (PD153035)","PD 153035"}

> <pdid>
PD002607

> <targets>
{EGFR,PTK}

> <classes>
{}

> <pubchem_cids>
{4705}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -2.6191    7.4957    0.0000 N   0  0
   -3.9225    8.2398    0.0000 C   0  0
   -5.2176    7.4830    0.0000 O   0  0
   -3.9308    9.7406    0.0000 C   0  0
   -5.2325   10.4861    0.0000 C   0  0
   -6.5289    9.7316    0.0000 Cl  0  0
   -5.2377   11.9861    0.0000 C   0  0
   -3.9413   12.7406    0.0000 C   0  0
   -2.6396   11.9952    0.0000 C   0  0
   -2.6344   10.4952    0.0000 C   0  0
   -1.3327    9.7498    0.0000 Cl  0  0
   -3.9073    5.2404    0.0000 C   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -2.6005    2.9949    0.0000 N   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 12  1  0
 18 19  1  0
  8 20  2  0
 20 21  1  0
 21 22  2  0
 22  6  1  0
  4 23  2  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 26  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28669

> <plate>
Kinase v5-2

> <well>
F12

> <supplier_cmpd_name>
RO495

> <ctcr_id>
4371

> <supplier_cmpd_id>
SY-RO495

> <smiles>
Cc1cc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)ccn2)nc(N)n1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{RO495,1258296-60-4,1258296604,C17H14Cl2N6O,SCHEMBL3514972,CHEMBL2142114,SYN1128,HMS3741O19,BCP21626,EX-A1857,EXA1857,ZINC95567045,"RO-495;RO 495","RO495;RO 495",NCGC00263200-01,NCGC0026320001,NCGC002
63200-02,NCGC0026320002,AS-16267,AS16267,DB-109762,DB109762,SY-RO495}

> <pdid>
PD144412

> <targets>
{TYK2}

> <classes>
{}

> <pubchem_cids>
{57519505}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  1  0            999 V2000
   -0.0034   -3.0047    0.0000 O   0  0
    1.2956   -3.7547    0.0000 C   0  0
    1.2951   -5.2547    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0  1  0  0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8933   -3.7570    0.0000 N   0  0
    3.8912   -5.2578    0.0000 S   0  0
    2.5909   -6.0056    0.0000 O   0  0
    2.5933   -4.5058    0.0000 O   0  0
    5.1894   -6.0109    0.0000 C   0  0
    5.1863   -7.5109    0.0000 C   0  0
    6.4838   -8.2636    0.0000 C   0  0
    7.7844   -7.5162    0.0000 C   0  0
    7.7875   -6.0162    0.0000 C   0  0
    6.4900   -5.2636    0.0000 C   0  0
    9.0825   -8.2693    0.0000 C   0  0
    9.0819   -9.7693    0.0000 C   0  0
   10.3806  -10.5199    0.0000 C   0  0
   11.6800   -9.7706    0.0000 C   0  0
   11.6807   -8.2706    0.0000 C   0  0
   10.3820   -7.5199    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  1
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  4 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  2  0
 13 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 19 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28670

> <plate>
Kinase v5-2

> <well>
F14

> <supplier_cmpd_name>
24BPSAP (MMP2/MMP-9 Inhibitor I)

> <ctcr_id>
7741

> <supplier_cmpd_id>
SY-24BPSAP

> <smiles>
OC(=O)[C@@H](Cc1ccccc1)N[S](=O)(=O)c2ccc(cc2)c3ccccc3

> <pd_targets>
{MMP9,MMP2,ADAMTS4}

> <pathway_gtopdb>
{Enzyme,Protease,"Metallo protease","Metallo protease MAM clan","Metallo protease M10A subfamily","Metallo protease M12B subfamily"}

> <pathway_chembl>
{Enzymes,"Peptidases and proteinases","MA: Metallo (M) Peptidases","M10: Matrix metallopeptidase","M12: Astacin/Adamalysin"}

> <pathway_reactome>
{"Developmental Biology",Disease,"Nervous system development","Diseases of metabolism","Axon guidance","Diseases of glycosylation","EPH-Ephrin signaling","Diseases associated with O-glycosylation of p
roteins","EPH-ephrin mediated repulsion of cells","Defective B3GALTL causes Peters-plus syndrome (PpS)"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"MP2/MMP9 INHIBITOR","MP 2/MMP 9 INHIBITOR","mmp-2/mmp-9 inhibitor i","mmp2/mmp9 inhibitor i","mmp 2/mmp 9 inhibitor i",CHEMBL49411,"(2R)-2-((4-Biphenylylsulfonyl)amino)-3-phenylpropionic Acid","(2R)
2((4Biphenylylsulfonyl)amino)3phenylpropionic Acid",(2R)2((4Biphenylylsulfonyl)amino)3p,SY-24BPSAP,"24BPSAP (MMP2/MMP-9 Inhibitor I)"}

> <pdid>
PD044247

> <targets>
{MMP/MMP9,gelatinases}

> <classes>
{}

> <pubchem_cids>
{10667540}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  0  0            999 V2000
   -1.7616   -9.1692    0.0000 C   0  0
   -0.7600   -8.0526    0.0000 N   0  0
    0.7077   -8.3622    0.0000 C   0  0
   -1.2256   -6.6258    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8813   -1.4408    0.0000 C   0  0
    5.0460   -2.3579    0.0000 C   0  0
    6.2823   -1.5084    0.0000 C   0  0
    7.6962   -2.0093    0.0000 O   0  0
    5.8565   -0.0701    0.0000 N   0  0
    4.3570   -0.0307    0.0000 C   0  0
    3.4982    1.1992    0.0000 O   0  0
    4.9973   -3.8578    0.0000 C   0  0
    6.2559   -4.6520    0.0000 C   0  0
    5.8646   -6.1001    0.0000 N   0  0
    4.3672   -6.1750    0.0000 C   0  0
    3.4207   -7.3387    0.0000 C   0  0
    1.9397   -7.1008    0.0000 C   0  0
    1.4052   -5.6993    0.0000 C   0  0
    2.3517   -4.5356    0.0000 C   0  0
    3.8327   -4.7735    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  7  1  0
 15 10  1  0
  9 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 16  1  0
 21 22  2  0
 17 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 23  1  0
 31 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28671

> <plate>
Kinase v5-2

> <well>
F16

> <supplier_cmpd_name>
GF109203X (Bisindolylmaleimide I)

> <ctcr_id>
200

> <supplier_cmpd_id>
SY-GF109203X

> <smiles>
CN(C)CCCn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45

> <pd_targets>
{PRKCE,RECQL,SMN1,MAPT,FFP,FTL,PHKA1,PRKCA,PIM1,SIRT2,PRKCZ,CYP3A4,PRKACA,PRKCB,PRKCH,SIRT1,MAPK1,TSHR,CYP2C9,GSK3B,PRKCQ,PRKCG,CCND1,CDK4,CCNB1,CCNB2,CCNB3,CDK1,KMT2A,MEN1,CYP1A2,PFMRK,PRKCD,CCNE1,CC
NE2,CDK2,LEF,TP53,PRKCI,KCNH2,LMTK3}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Unclassified protein","Membrane receptor","Transcription factor","Ion channel",Kinase,Reader,Transferase,Eraser,"Cytochrome P450","Family A G 
protein-coupled receptor",Protease,"Voltage-gated ion channel","Protein Kinase","Methyl-lysine/arginine binding protein","Histone deacetylase","Cytochrome P450 family 3","Peptide receptor (family A GP
CR)","Cytochrome P450 family 2",Bromodomain,"Cytochrome P450 family 1","Metallo protease","Potassium channels","AGC protein kinase group","Tudor domain","CAMK protein kinase group","HDAC class III","C
ytochrome P450 family 3A","CMGC protein kinase group","Glycohormone receptor","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Metallo protease MAE clan","Voltage-gated potassium channel","AGC
 protein kinase PKC family","CAMK protein kinase PIM family","Cytochrome P450 3A4","AGC protein kinase PKA family","CMGC protein kinase MAPK family","Cytochrome P450 2C9","CMGC protein kinase GSK fami
ly","CMGC protein kinase CDK family","Cytochrome P450 1A1","Metallo protease M34 family","AGC protein kinase PKC eta subfamily","AGC protein kinase PKC alpha subfamily","AGC protein kinase PKC iota su
bfamily","CMGC protein kinase ERK1","AGC protein kinase PKC delta subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Cytochrome P450","G protein-coupled receptors","Voltage-gated ion channels","Catalytic receptors","AGC: Containi
ng PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","3.5.1.- Histone deacetylases (HDACs)","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Glycoprotein hormo
ne receptors","CYP2 family: drug metabolising subset","CYP1 family","Potassium channels","Receptor kinases","Protein kinase C (PKC) family","PIM family","Protein kinase A (PKA) family","Mitogen-activa
ted protein kinases (MAP kinases)","Glycogen synthase kinase (GSK) family","Voltage-gated potassium channels","TK: Tyrosine kinase","Eta subfamily","Delta subfamily","Iota subfamily","Alpha subfamily"
,"ERK subfamily","GSK subfamily","Receptor tyrosine kinases (RTKs)","Type XVIII RTKs: LMR family"}

> <pathway_reactome>
{"Immune System","Metabolism of RNA","Neuronal System","Vesicle-mediated transport","Signal Transduction",Disease,"Cell Cycle",Metabolism,"Gene expression (Transcription)","Muscle contraction","Innate
 Immune System","Metabolism of non-coding RNA","Transmission across Chemical Synapses","Membrane Trafficking","Signaling by GPCR","Diseases of signal transduction by growth factor receptors and second
 messengers",Mitotic,"Signaling by Nuclear Receptors","Metabolism of lipids","RNA Polymerase II Transcription","Infectious disease","Biological oxidations","Intracellular signaling by second messenger
s","Cell Cycle Checkpoints","Death Receptor Signalling","Cardiac conduction","Fcgamma receptor (FCGR) dependent phagocytosis","snRNP Assembly","Neurotransmitter receptors and postsynaptic signal trans
mission","trans-Golgi Network Vesicle Budding","GPCR downstream signalling","FLT3 signaling in disease","M Phase","ESR-mediated signaling","Biosynthesis of specialized proresolving mediators (SPMs)","
Mitotic G2-G2/M phases","Generic Transcription Pathway","Toll-like Receptor Cascades","Leishmania infection","Phase I - Functionalization of compounds","SARS-CoV Infections","DAG and IP3 signaling","U
ptake and actions of bacterial toxins","G1/S DNA Damage Checkpoints","p75 NTR receptor-mediated signalling","Phase 3 - rapid repolarisation","Role of phospholipids in phagocytosis","Activation of NMDA
 receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis","G alpha (i) signalling events","Signaling by FLT3 ITD and TKD mutants","Mitotic Metaphase and Anaphase","Extra-nuclear estrog
en signaling","Biosynthesis of DHA-derived SPMs","G2/M Transition","Mitotic Prophase","G alpha (z) signalling events","FOXO-mediated transcription","Toll Like Receptor 5 (TLR5) Cascade","Leishmania pa
rasite growth and survival","Cytochrome P450 - arranged by substrate type","SARS-CoV-1 Infection","Glutamate binding","activation of AMPA receptors and synaptic plasticity","CaM pathway","Uptake and f
unction of anthrax toxins","p53-Dependent G1/S DNA damage checkpoint","p75NTR signals via NF-kB","Post NMDA receptor activation events","Visual phototransduction","STAT5 activation downstream of FLT3 
ITD mutants","Mitotic Anaphase","Estrogen-stimulated signaling through PRKCZ","Biosynthesis of maresins","Centrosome maturation","Nuclear Envelope Breakdown","Regulation of FOXO transcriptional activi
ty by acetylation","MyD88 cascade initiated on plasma membrane","Anti-inflammatory response favouring Leishmania parasite infection",Xenobiotics,"SARS-CoV-1 Genome Replication and Transcription","Traf
ficking of AMPA receptors","Calmodulin induced events","p53-Dependent G1 DNA Damage Response","p75NTR recruits signalling complexes","Activation of AMPK downstream of NMDARs","The phototransduction ca
scade","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","Loss of proteins required for interphase microtubule organization from the centrosome","Depolymerisation of the Nuclear L
amina","MAP kinase activation","ADORA2B mediated anti-inflammatory cytokines production","CYP2E1 reactions","Replication of the SARS-CoV-1 genome","Trafficking of GluR2-containing AMPA receptors","Aro
matic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Stabilization of p53",Inactivation,"recovery and regulation of the phototransduction cascade","Initiation of Nuclear Envelope (NE) Refor
mation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Autodegradation of the E3 ubiquitin ligase COP1","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{PDPK1,PIM1,PRKCI,PRKCZ}

> <broad_moa>
{"PKC inhibitor"}

> <synonyms>
{"bisindolylmaleimide i",133052-90-1,133052901,"GF 109203X",GF109203X,"Go 6850",GF-109203X,Go-6850,Go6850,UNII-L79H6N0V6C,UNIIL79H6N0V6C,2-(1-(3-dimethylaminopropyl)indol-3-yl)-3-(indol-3-yl)maleimide
,2(1(3dimethylaminopropyl)indol3yl)3(indol3yl)maleimide,"G&ouml; 6850",CHEMBL7463,L79H6N0V6C,2-(1-(3-Dimethylaminopropyl)indol-3-y,2(1(3Dimethylaminopropyl)indol3y,T6513,"EMD 203290",SY-GF109203X,741,
EI-246,"Bisindolylmaleimide I",203290,"GF109203X (Bisindolylmaleimide I)"}

> <pdid>
PD007247

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{2396}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
   -0.2237   -5.5078    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 O   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -5.2003   -1.4932    0.0000 C   0  0
   -6.4994   -0.7433    0.0000 C   0  0
   -7.7985   -1.4932    0.0000 C   0  0
   -7.7985   -2.9932    0.0000 C   0  0
   -6.4995   -3.7433    0.0000 N   0  0
   -5.2004   -2.9933    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.5988    1.5004    0.0000 C   0  0
    3.8985    2.2508    0.0000 C   0  0
    5.1983    3.0013    0.0000 C   0  0
    5.1978    4.5013    0.0000 C   0  0
    6.4970    3.7519    0.0000 C   0  0
    6.4978    2.2521    0.0000 O   0  0
    2.5536   -4.4230    0.0000 C   0  0
    4.0417   -4.4398    0.0000 N   0  0
    4.4674   -5.8782    0.0000 O   0  0
    3.2310   -6.7275    0.0000 N   0  0
    2.0412   -5.8141    0.0000 C   0  0
    0.6003   -6.2309    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 13  1  0
 10 19  2  0
 19  3  1  0
 19  6  1  0
  7 20  1  0
 20 21  3  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 22 25  1  0
  4 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 30 26  1  0
 30 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28672

> <plate>
Kinase v5-2

> <well>
F18

> <supplier_cmpd_name>
GSK690693

> <ctcr_id>
5019

> <supplier_cmpd_id>
SY-GSK690693

> <smiles>
CCn1c(nc2c(ncc(OCC3CCCNC3)c12)C#CC(C)(C)O)c4nonc4N

> <pd_targets>
{PRKACB,ULK1,KIT,RPS6KA4,PRKD1,PKNB,PKN2,ULK2,PRKG2,MAP3K19,PRKACA,PRKD3,TAOK3,NUAK2,PIM2,MELK,LATS2,HIPK1,PAK5,AKT1,PRKCH,PRKCE,PRKAA2,DAPK3,ROCK1,AKT2,ROCK2,AKT3,GSK3B,DAPK1,HIPK3,RET,PRKCI,PAK1,PDG
FRB,PRKG1,PAK4,PRKX,EIF2AK2,CLK2,CAMK4,MAP3K3,PIM1,SGK3,CAMK1D,HIPK2,STK36,NLK,PAK6,TAOK1,PIM3,PIP5K1C,CIT,TAOK2,STK26,GSK3A,GRK7,PKN1,PRKCD,RPS6KA5,RPS6KA1,GRK1,DCLK1,PAK2,DCLK3,CHEK2,MAP3K2,NUAK1,PR
KCQ,MARK2,SIK2,PRKCB,PRKCA,PRKCG,PRKCZ,PRKACG}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","AGC protein kinase group","Other protein kinase group","TK protein kinase group","CAMK protein kinase group","STE protein kinase group","CMGC protein kinas
e group","AGC protein kinase PKA family","Other protein kinase ULK family","Tyrosine protein kinase PDGFR family","AGC protein kinase RSK family","CAMK protein kinase PKD family","AGC protein kinase P
KN family","AGC protein kinase PKG family","STE protein kinase STE11 family","STE protein kinase STE20 family","CAMK protein kinase CAMK1 family","CAMK protein kinase PIM family","AGC protein kinase N
DR family","CMGC protein kinase DYRK family","AGC protein kinase AKT family","AGC protein kinase PKC family","CAMK protein kinase DAPK family","AGC protein kinase DMPK family","CMGC protein kinase GSK
 family","Tyrosine protein kinase Ret family","Other protein kinase PEK family","CMGC protein kinase CLK family","AGC protein kinase SGK family","CMGC protein kinase MAPK family","AGC protein kinase G
RK family","CAMK protein kinase DCAMK1 family","CAMK protein kinase RAD53 family","AGC protein kinase MSK subfamily","STE protein kinase TAO subfamily","CAMK protein kinase NuaK subfamily","CAMK prote
in kinase MELK subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase PAKB subfamily","AGC protein kinase PKC eta subfamily","CAMK protein kinase AMPK subfamily","AGC protein kinase ROCK 
subfamily","AGC protein kinase PKC iota subfamily","STE protein kinase PAKA subfamily","Other protein kinase PKR","STE protein kinase MEKK2","CMGC protein kinase nmo subfamily","AGC protein kinase CRI
K subfamily","STE protein kinase YSK subfamily","AGC protein kinase GRK subfamily","AGC protein kinase PKC delta subfamily","AGC protein kinase RSK subfamily","CAMK protein kinase MARK subfamily","CAM
K protein kinase QIK subfamily","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast
 Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Lipid modifying kinases","Protein kinase A (PKA) family","Other protein kinases","TK: Tyrosine kinase","R
SK family","Protein kinase D (PKD) family","Protein kinase N (PKN) family","Protein kinase G (PKG) family","STE20 family","CAMK-like (CAMKL) family","PIM family","NDR family","Dual-specificity tyrosin
e-(Y)-phosphorylation regulated kinase (DYRK) family","Akt (Protein kinase B","PKB) family","Protein kinase C (PKC) family","Death-associated kinase (DAPK) family","DMPK family","Glycogen synthase kin
ase (GSK) family","CLK family","CAMK1 family","STE11 family","SGK family","Mitogen-activated protein kinases (MAP kinases)","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","G
 protein-coupled receptor kinases (GRKs)","DCAMKL family","Unc-51-like kinase (ULK) family","Receptor tyrosine kinases (RTKs)","MSK subfamily","STE20 subfamily","TAO subfamily","NuaK subfamily","MELK 
subfamily","HIPK subfamily","PAKB subfamily","Eta subfamily","AMPK subfamily","Rho kinase","GSK subfamily","Iota subfamily","PAKA subfamily","PEK family","nmo subfamily","Other DMPK family kinases","Y
SK subfamily","Opsin/rhodopsin kinases","Delta subfamily","RSK subfamily","CHK1 subfamily","MARK subfamily","QIK subfamily","Alpha subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Ty
pe XIV RTKs: RET","Other PEK family kinases"}

> <pathway_reactome>
{"Signal Transduction",Autophagy,Disease,"Developmental Biology",Metabolism,"Cell Cycle","Gene expression (Transcription)","Immune System","Programmed Cell Death",Hemostasis,"Transport of small molecu
les","Intracellular signaling by second messengers",Macroautophagy,"Diseases of signal transduction by growth factor receptors and second messengers","Nervous system development","Metabolism of lipids
","Signaling by Rho GTPases","MAPK family signaling cascades",Mitotic,"Signaling by Hippo","RNA Polymerase II Transcription","Signaling by GPCR","Innate Immune System",Apoptosis,"Signaling by Receptor
 Tyrosine Kinases","Infectious disease","Death Receptor Signalling","Platelet homeostasis","Disorders of Developmental Biology","Cytokine Signaling in Immune system","Ion channel transport","Signaling
 by WNT","DAG and IP3 signaling","Selective autophagy","Signaling by KIT in disease","Axon guidance","Sphingolipid metabolism","RHO GTPase Effectors","MAPK1/MAPK3 signaling","Mitotic G2-G2/M phases","
Generic Transcription Pathway","GPCR downstream signalling","Fcgamma receptor (FCGR) dependent phagocytosis","Caspase activation via extrinsic apoptotic signalling pathway","Signaling by Insulin recep
tor","SARS-CoV Infections","p75 NTR receptor-mediated signalling","PIP3 activates AKT signaling","Nitric oxide stimulates guanylate cyclase","Leishmania infection","Influenza Infection","Disorders of 
Nervous System Development","Signaling by Interleukins","FLT3 signaling in disease","Stimuli-sensing channels","Beta-catenin independent WNT signaling","M Phase","Apoptotic execution phase","Toll-like
 Receptor Cascades","HIV Infection","CaM pathway",Mitophagy,"Drug resistance of KIT mutants","L1CAM interactions","Sphingolipid de novo biosynthesis","RHO GTPases activate PKNs","RAF/MAP kinase cascad
e","G2/M Transition","Transcriptional Regulation by TP53","Signaling by ROBO receptors","G alpha (z) signalling events","Role of phospholipids in phagocytosis","Caspase activation via Dependence Recep
tors in the absence of ligand","Semaphorin interactions","Insulin receptor signalling cascade","SARS-CoV-1 Infection","RET signaling","p75NTR signals via NF-kB","EPH-Ephrin signaling","Negative regula
tion of the PI3K/AKT network","cGMP effects","Leishmania parasite growth and survival","NS1 Mediated Effects on Host Pathways","Pervasive developmental disorders","Interleukin-1 family signaling","Sig
naling by FLT3 ITD and TKD mutants","Ca2+ pathway","Mitotic Metaphase and Anaphase","RHO GTPases activate CIT","Apoptotic cleavage of cellular proteins","G alpha (i) signalling events","Toll Like Rece
ptor 5 (TLR5) Cascade","Host Interactions of HIV factors","Mitotic Prophase","Calmodulin induced events","Receptor Mediated Mitophagy","Dasatinib-resistant KIT mutants","Recycling pathway of L1","RAS 
processing","Centrosome maturation","Regulation of TP53 Activity","Activation of RAC1","Sema4D in semaphorin signaling","IRS-mediated signalling","SARS-CoV-1 Genome Replication and Transcription","p75
NTR recruits signalling complexes","EPHB-mediated forward signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Anti-inflammatory response favouring Leishmania parasite infection","Inhibition o
f PKR","Loss of function of MECP2 in Rett syndrome","Interleukin-1 signaling","STAT5 activation downstream of FLT3 ITD mutants","Mitotic Anaphase","SEMA3A-Plexin repulsion signaling by inhibiting Inte
grin adhesion","Visual phototransduction","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","MyD88 cascade initiated on plasma membrane","The role of Ne
f in HIV-1 replication and disease pathogenesis","Nuclear Envelope Breakdown","PKA-mediated phosphorylation of CREB","Loss of proteins required for interphase microtubule organization from the centros
ome","Regulation of TP53 Activity through Phosphorylation","Regulation of TP53 Expression and Degradation","Sema4D induced cell migration and growth-cone collapse","PI3K Cascade","Replication of the S
ARS-CoV-1 genome","ADORA2B mediated anti-inflammatory cytokines production","Loss of phosphorylation of MECP2 at T308","Separation of Sister Chromatids","The phototransduction cascade","MAP kinase act
ivation","Nef and signal transduction","Depolymerisation of the Nuclear Lamina","PKA activation","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","PKB-mediated events",Inactivat
ion,"recovery and regulation of the phototransduction cascade","MAPK targets/ Nuclear events mediated by MAP kinases","PDE3B signalling","CREB phosphorylation"}

> <broad_targets>
{AKT1,AKT2,AKT3,PAK4,PAK6,PAK7,PRKCQ,PRKG1,PRKX}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{SCHEMBL2195376,CHEMBL2140607,CHEBI:91396,HMS3244O05,HMS3244O06,HMS3244P05,HMS3295E23,HMS3654K04,AKOS032947266,NCGC00387843-03,NCGC0038784303,AK103308,FT-0770878,FT0770878,S-7812,S7812,BRD-A87137733-0
01-01-5,BRDA87137733001015,Q27163256,T6285,SY-690693,S1113,GSK690693}

> <pdid>
PD011131

> <targets>
{AKT1,2,3,Akt}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{16048642}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
   -1.3109   -5.2364    0.0000 C   0  0
   -0.0156   -5.9927    0.0000 S   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -3.9015    3.7525    0.0000 Cl  0  0
   -6.4995    3.7483    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -6.4948    0.7483    0.0000 C   0  0
   -6.4924   -0.7517    0.0000 Cl  0  0
    1.2935   -3.7495    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  3
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 17 19  1  0
 19 12  1  0
 19 20  2  0
 20  9  1  0
 14 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 21  1  0
 27 28  1  0
  7 29  2  0
 29  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28673

> <plate>
Kinase v5-2

> <well>
F20

> <supplier_cmpd_name>
PD173955

> <ctcr_id>
526

> <supplier_cmpd_id>
SY-PD173955

> <smiles>
CSc1cccc(Nc2ncc3C=C(C(=O)N(C)c3n2)c4c(Cl)cccc4Cl)c1

> <pd_targets>
{FGFR1,PDGFRA,PDGFRB,ABL1,TEC,FLT3,EPHB3,AURKC,ACVR1,ACVR2A,DDR1,TNK1,CSF1R,EGFR,EPHA1,TIE1,NEK1,CDC42BPG,TAOK1,FGFR4,MAP3K4,BRAF,RET,TESK1,TAOK3,STK26,MAP3K19,NEK11,PKMYT1,NEK5,WEE2,FGFR3,STK32A,MARK
3,SMO,TYRO3,STK25,FLT1,MAP3K11,LCK,MARK2,MAP3K9,NIM1K,PTK2B,DDR2,KIT,TNK2,ACVR2B,BLK,BMX,HCK,LYN,PTK6,MAP3K2,LIMK1,EPHB1,JAK2,MAPK14,SRC,YES1,NLK,MAP2K3,RIPK1,STK35,MAP4K1,MAP2K1,MAP2K6,RIPK2,MAP2K4,C
DPK1,STK24,PLK3,EPHA2,TGFBR1,SIK1,RAF1,SYK,CDC42BPB,STK3,SIK2,MAP2K5,MINK1,ABL2,LIMK2,TAOK2,EPHB2,MYLK2,BRSK1,LRRK2,JAK1,BTK,MET,EIF2AK4,MAPK4,MAP3K3,EPHB4,CSK,FER,COQ8A,FGFR2,PIP4K2C,ACVRL1,TEK,STK4,
NEK2,EPHA3,ACVR1B,EPHA5,MYLK3,SBK3,JAK3,ERBB3,FES,TXK,CDC42BPA,MAP4K3,SLK,TNNI3K,MAP2K2,SRMS,BCR,MAPK8,TYK2,MAP4K2,ERBB4,TGFBR2,BRSK2,MST1R,FGR,STK36,STK32B,COQ8B,EPHA6,MAPK11,BMPR1A,EPHB6,GAK,STK10,M
AP3K20,FYN,FLT4,KDR,MAP3K10,MAPK6,EPHA4,MAP4K4,BMPR1B,FRK,EPHA8,WEE1,NTRK3,TNIK,MAP4K5,SIK3,ALK,NPM1}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Unclassified protein",Kinase,"Frizzled family G protein-coupled receptor",Transferase,"Protein Kinase","Smoothened receptor (frizzled family GPCR)","TK protein kinase grou
p","Other protein kinase group","TKL protein kinase group","AGC protein kinase group","STE protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Atypical protein kinase group"
,"Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Eph family","Other prot
ein kinase AUR family","TKL protein kinase STKR family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Ack family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Tie fam
ily","Other protein kinase NEK family","AGC protein kinase DMPK family","STE protein kinase STE20 family","STE protein kinase STE11 family","TKL protein kinase RAF family","Tyrosine protein kinase Ret
 family","TKL protein kinase LISK family","Other protein kinase WEE family","AGC protein kinase YANK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Axl family","Tyrosine protein k
inase VEGFR family","TKL protein kinase MLK family","Tyrosine protein kinase Src family","Tyrosine protein kinase Fak family","Tyrosine protein kinase JakA family","CMGC protein kinase MAPK family","S
TE protein kinase STE7 family","TKL protein kinase RIPK family","Other protein kinase NKF4 family","Other protein kinase PLK family","Tyrosine protein kinase Syk family","CAMK protein kinase MLCK fami
ly","TKL protein kinase LRRK family","Tyrosine protein kinase Met family","Other protein kinase PEK family","Tyrosine protein kinase Csk family","Tyrosine protein kinase Fer family","Other protein kin
ase NKF1 family","Atypical protein kinase BCR family","Other protein kinase ULK family","Atypical protein kinase ABC1 family","Other protein kinase NAK family","Tyrosine protein kinase Trk family","TK
L protein kinase STKR1","TKL protein kinase STKR Type 2 subfamily","AGC protein kinase GEK subfamily","STE protein kinase TAO subfamily","TKL protein kinase TESK subfamily","STE protein kinase YSK sub
family","Other protein kinase Nek11","Other protein kinase WEE1","CAMK protein kinase MARK subfamily","TKL protein kinase MLK subfamily","CAMK protein kinase NIM1 subfamily","STE protein kinase MEKK2"
,"TKL protein kinase LIMK subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase nmo subfamily","STE protein kinase KHS subfamily","TKL protein kinase STKR Type 1 subfamily","CAMK protein
 kinase QIK subfamily","STE protein kinase MST subfamily","STE protein kinase MSN subfamily","CAMK protein kinase BRSK subfamily","Other protein kinase GCN2 subfamily","CMGC protein kinase ERK3","STE 
protein kinase SLK subfamily","TKL protein kinase HH498 subfamily","Tyrosine protein kinase Srm","CMGC protein kinase JNK subfamily","Atypical protein kinase ABC1-A subfamily","Tyrosine protein kinase
 SrcA"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","G protein-coupled receptors","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11
","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Class Frizzled GPCRs","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"Lipid modifying kinases","TK: Tyrosine kina
se","Other protein kinases","TKL: Tyrosine kinase-like","DMPK family","STE20 family","STE11 family","YANK family","CAMK-like (CAMKL) family","Mitogen-activated protein kinases (MAP kinases)","STE7 fam
ily","Myosin Light Chain Kinase (MLCK) family","ABC1 family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinase
s (nRTKs)","Aurora kinase (Aur) family","Receptor serine/threonine kinase (RSTK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","GEK subfamily","TAO subfamily","RAF family","LIM
 domain kinase (LISK) family","YSK subfamily","STE20 subfamily","WEE family","MARK subfamily","Mixed Lineage Kinase (MLK) family","NIM1 subfamily","p38 subfamily","nmo subfamily","Receptor interacting
 protein kinase (RIPK) family","NKF4 family","KHS subfamily","Polo-like kinase (PLK) family","QIK subfamily","MST subfamily","MSN subfamily","BRSK subfamily","Leucine-rich repeat kinase (LRRK) family"
,"PEK family","ERK subfamily","ABC1-B subfamily","NKF1 family","SLK subfamily","JNK subfamily","Unc-51-like kinase (ULK) family","Numb-associated kinase (NAK) family","Type V RTKs: FGF (fibroblast gro
wth factor) receptor family","Abl family","Tec family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIII RTKs: Ephrin receptor family","Type I receptor serine/threonine kinases","Type 
II receptor serine/threonine kinases","Type XVI RTKs: DDR (collagen receptor) family","Ack family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XII RTKs: TIE family of angiopoie
tin receptors","Type XIV RTKs: RET","TESK subfamily","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","MLK subfa
mily","Src family","Fak family","LIMK subfamily","Janus kinase (JakA) family","Syk family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","GCN2 subfamily","Csk family","Fer family","HH4
98 subfamily","Type VII RTKs: Neurotrophin receptor/Trk family"}

> <pathway_reactome>
{Disease,"Immune System","Signal Transduction","Developmental Biology","Extracellular matrix organization","Gene expression (Transcription)","Cell Cycle","Cell-Cell communication","Programmed Cell Dea
th","Organelle biogenesis and maintenance",Metabolism,"Circadian Clock","Cellular responses to external stimuli","Neuronal System","Vesicle-mediated transport","Diseases of signal transduction by grow
th factor receptors and second messengers","Infectious disease","Cytokine Signaling in Immune system","Signaling by Receptor Tyrosine Kinases","Nervous system development","Signaling by NODAL","Non-in
tegrin membrane-ECM interactions","RNA Polymerase II Transcription","Signaling by GPCR",Mitotic,"Intracellular signaling by second messengers","Cell junction organization",Apoptosis,"Cilium Assembly",
"Metabolism of lipids","Innate Immune System","Signaling by WNT","MAPK family signaling cascades","Signaling by Hippo","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases","Sign
aling by TGFB family members","Transmission across Chemical Synapses","Membrane Trafficking","Cell Cycle Checkpoints","Signaling by FGFR in disease","Leishmania infection","Signaling by Interleukins",
"Signaling by Insulin receptor","Axon guidance","Regulation of signaling by NODAL","Generic Transcription Pathway","GPCR downstream signalling","M Phase","Signaling by FGFR","PIP3 activates AKT signal
ing","Signaling by NTRKs","Cell-extracellular matrix interactions","Apoptotic execution phase","Mitotic G2-G2/M phases","Oncogenic MAPK signaling","Cargo trafficking to the periciliary membrane","Sign
aling by VEGF","Signaling by PDGFR in disease","HIV Infection","Signaling by KIT in disease","Phospholipid metabolism","Mitotic G1 phase and G1/S transition","Toll-like Receptor Cascades","Beta-cateni
n independent WNT signaling","Signaling by TGF-beta Receptor Complex in Cancer","MAPK1/MAPK3 signaling","Cellular Senescence","Signaling by PTK6","Interferon Signaling","Response of EIF2AK4 (GCN2) to 
amino acid deficiency","MAPK6/MAPK4 signaling","Signaling by SCF-KIT","Signaling by BMP","Regulation of mitotic cell cycle","Fc epsilon receptor (FCERI) signaling","Neurotransmitter receptors and post
synaptic signal transmission","Signaling by MST1","trans-Golgi Network Vesicle Budding","Neutrophil degranulation","G2/M Checkpoints","Signaling by FGFR1 in disease","Parasite infection",Interleukin-3
,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","EPH-Ephrin signaling","Transcriptional Regulation by VENTX","G alpha (q) signalling events","Mitotic Metaphase and Anaphase
","Signaling by FGFR4","Negative regulation of the PI3K/AKT network","Signaling by NTRK1 (TRKA)","RET signaling","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","A
poptotic cleavage of cellular proteins","G2/M Transition","Signaling by FGFR3 in disease","Signaling by RAS mutants","BBSome-mediated cargo-targeting to cilium","VEGF ligand-receptor interactions","Dr
ug resistance of PDGFR mutants","Host Interactions of HIV factors","Interleukin-2 family signaling","Drug resistance of KIT mutants","Transcriptional regulation by RUNX1","PI Metabolism","Leishmania p
arasite growth and survival","G1 Phase","Semaphorin interactions","Toll Like Receptor 5 (TLR5) Cascade","Ca2+ pathway","Toll Like Receptor 4 (TLR4) Cascade","Transcriptional Regulation by TP53","Loss 
of Function of SMAD2/3 in Cancer","RAF/MAP kinase cascade","Oxidative Stress Induced Senescence","Signaling by ROBO receptors","PTK6 promotes HIF1A stabilization","Antiviral mechanism by IFN-stimulate
d genes","Interleukin-1 family signaling","Signaling by FGFR2 in disease","APC/C-mediated degradation of cell cycle proteins","FCERI mediated Ca+2 mobilization","PTK6 Down-Regulation","Interferon alph
a/beta signaling","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis","VEGFA-VEGFR2 Pathway","PTEN Regulation","G2/M DNA damage checkpoint","Signaling by NTRK3
 (TRKC)","FGFR1 mutant receptor activation","Leishmania phagocytosis","IRS-mediated signalling","EPHB-mediated forward signaling","Gastrin-CREB signalling pathway via PKC and MAPK","EPHA-mediated grow
th cone collapse","Mitotic Anaphase","Downstream signaling of activated FGFR4",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signalling to ERKs","Cyclin A/B1/B2 associated events during G2/M trans
ition","Signaling by FGFR3 point mutants in cancer","Signaling downstream of RAS mutants","VEGF binds to VEGFR leading to receptor dimerization","Imatinib-resistant PDGFR mutants","The role of Nef in 
HIV-1 replication and disease pathogenesis","Interleukin-2 signaling","Dasatinib-resistant KIT mutants","RUNX1 regulates transcription of genes involved in BCR signaling","Synthesis of PIPs at the pla
sma membrane","Anti-inflammatory response favouring Leishmania parasite infection","Cyclin D associated events in G1","Sema4D in semaphorin signaling","MyD88 cascade initiated on plasma membrane","MyD
88-independent TLR4 cascade","Regulation of TP53 Activity","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Negative regulation of MAPK pathway","Signalling to ERK5","Role of ABL in ROBO-SLIT signal
ing","ISG15 antiviral mechanism","Interleukin-1 signaling","FGFR2 mutant receptor activation","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Interleukin-15 signaling",
"CRMPs in Sema3A signaling","Regulation of IFNA signaling","Post NMDA receptor activation events","VEGFR2 mediated cell proliferation","Regulation of PTEN stability and activity","Chk1/Chk2(Cds1) medi
ated inactivation of Cyclin B:Cdk1 complex","Activated NTRK3 signals through PI3K","Signaling by activated point mutants of FGFR1","FCGR3A-mediated phagocytosis","PI3K Cascade","EGFR Transactivation b
y Gastrin","Separation of Sister Chromatids","FRS-mediated FGFR4 signaling","Prolonged ERK activation events","FGFR3 mutant receptor activation","Nef-mediates down modulation of cell surface receptors
 by recruiting them to clathrin adapters","Nef and signal transduction","FCGR3A-mediated IL10 synthesis","Sema4D induced cell migration and growth-cone collapse","MAP kinase activation","Signalling to
 RAS","TRIF(TICAM1)-mediated TLR4 signaling","Regulation of TP53 Activity through Acetylation","Regulation of TP53 Activity through Phosphorylation","Negative feedback regulation of MAPK pathway","Sem
a4D mediated inhibition of cell attachment and migration","Activated point mutants of FGFR2","APC/C:Cdc20 mediated degradation of mitotic proteins","Long-term potentiation","ARMS-mediated activation",
"Signaling by activated point mutants of FGFR3","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","activated TAK1 mediates p38 MAPK activation"
,"IKK complex recruitment mediated by RIP1","Frs2-mediated activation","PI5P Regulates TP53 Acetylation","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","APC:Cdc
20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Activation of the AP-1 family of transcription factors","APC-Cdc20 mediated degradation of Nek2A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{BDBM6568,GTPL5699,DTXSID90332241,SYN1061,BCPP000124,BCP02294,EX-A2125,EXA2125,ZINC2047743,AKOS026750643,BCP9001059,PD173955,260415-63-2,260415632,PD-173955,"Pd 173955",CHEMBL386051,PD-0173955,PD01739
55,CHEBI:49791,C21H16cl2N4OS,PubChem22476,PD-17395,PD17395,SCHEMBL256712,CS-3550,CS3550,DB025,T3063,SY-PD173955,S7269}

> <pdid>
PD007860

> <targets>
{BCR-ABL,c-Src,Bcr-Abl}

> <classes>
{}

> <pubchem_cids>
{447077}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 40  0  0  0  0            999 V2000
    2.5741  -12.0007    0.0000 N   0  0
    2.5766  -10.5007    0.0000 C   0  0
    1.2787   -9.7486    0.0000 C   0  0
    1.2811   -8.2486    0.0000 C   0  0
    2.5814   -7.5006    0.0000 C   0  0
    3.8792   -8.2528    0.0000 C   0  0
    3.8768   -9.7528    0.0000 N   0  0
    2.5868   -5.9998    0.0000 C   0  0
    1.2903   -5.2455    0.0000 O   0  0
    3.8888   -5.2533    0.0000 N   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 O   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 N   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
 19 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 33 34  1  0
 34 26  1  0
 34 35  2  0
 35 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28674

> <plate>
Kinase v5-2

> <well>
F22

> <supplier_cmpd_name>
YM201636

> <ctcr_id>
1416

> <supplier_cmpd_id>
SY-YM201636

> <smiles>
Nc1ccc(cn1)C(=O)Nc2cccc(c2)c3nc(N4CCOCC4)c5oc6ncccc6c5n3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{371942-69-7,371942697,YM201636,YM-201636,"YM 201636",PubChem22459,cc-386,cc386,MLS006010997,SCHEMBL258416,CHEMBL2178735,CHEBI:91382,AOB1919,DTXSID90433303,EX-A037,EXA037,QCR-257,QCR257,BCPP000006,HMS
3229J15,HMS3295C07,HMS3654F03,AMY23718,BCP01972,ABP000099,MFCD16038303,s1219,ZI,T6110,SY-YM201636,"EMD 524611",524611}

> <pdid>
PD011051

> <targets>
{PIKfyve,"PIKfyve Inhibitor",Autophagy,"Influenza Virus",PI3K}

> <classes>
{Anti-infection,Autophagy,PI3K/Akt/mTOR}

> <pubchem_cids>
{9956222}

$$$$
UTKinase_V5
  SciTegic11012413002D

 15 15  0  0  0  0            999 V2000
    7.3090   -2.1076    0.0000 Cl  0  0
    4.8086   -5.7146    0.0000 C   0  0
    4.0559   -4.4171    0.0000 N   0  0
    4.8036   -3.1167    0.0000 C   0  0
    2.5551   -4.4192    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6923   -4.0811    0.0000 O   0  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14  6  1  0
 14 15  2  0
M  END
> <name>
UTKinase_V5

> <id>
28675

> <plate>
Kinase v5-2

> <well>
H04

> <supplier_cmpd_name>
TER14687

> <ctcr_id>
5373

> <supplier_cmpd_id>
SY-TER14687

> <smiles>
Cl.CN(C)CC1Cc2ccccc2C1=O

> <pd_targets>
{MAP,METAP1}

> <pathway_gtopdb>
{Enzyme,Protease,"Metallo protease","Metallo protease MG clan","Metallo protease M24A subfamily"}

> <pathway_chembl>
{Enzymes,"Peptidases and proteinases","MG: Metallo (M) Peptidases","M24: Methionyl aminopeptidase"}

> <pathway_reactome>
{"Signal Transduction","Signaling by GPCR","GPCR downstream signalling","G alpha (i) signalling events","Visual phototransduction","The phototransduction cascade",Inactivation,"recovery and regulation
 of the phototransduction cascade"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ter14687,16931-84-3,16931843,"2-((Dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride","2((Dimethylamino)methyl)2,3dihydro1Hinden1one hydrochloride",CHEMBL3337638,"(+/-)-2-N,N-Dimethylamin
omethyl-1-indanone, HCl","(+/)2N,NDimethylaminomethyl1indanone, HCl","1H-Inden-1-one, 2,3-dihydro-2-((dimethylamino)methyl)-, hydrochloride","1HInden1one, 2,3dihydro2((dimethylamino)methyl), hydrochlo
ride",SCHEMBL2124625,NSC266,SY-TER14687,TER14687}

> <pdid>
PD136828

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{204802}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
   -0.6811   -9.3430    0.0000 C   0  0
   -0.2222   -7.9149    0.0000 C   0  0
    1.2028   -7.4466    0.0000 C   0  0
    1.1979   -5.9466    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5532   -4.4223    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.1079   -6.7042    0.0000 C   0  0
   -2.6061   -6.7008    0.0000 C   0  0
   -3.3604   -7.9983    0.0000 C   0  0
   -4.8612   -7.9948    0.0000 C   0  0
   -5.6077   -6.6938    0.0000 O   0  0
   -5.6151   -9.2916    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  7  1  0
 16 11  1  0
  5 17  2  0
 17  2  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 20 22  2  0
M  END
> <name>
UTKinase_V5

> <id>
28676

> <plate>
Kinase v5-2

> <well>
H06

> <supplier_cmpd_name>
SU-5402

> <ctcr_id>
7738

> <supplier_cmpd_id>
SY-SU-5402

> <smiles>
Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O

> <pd_targets>
{FGFR1,PDGFRB,SRC,KDR,FLT1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase VEG
FR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type V RTKs: FGF (fibroblast growth factor) recept
or family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Diseases of signal transduction by growth factor receptors and second messengers","Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases
","Signaling by FGFR in disease","PIP3 activates AKT signaling","Signaling by NTRKs","Signaling by VEGF","Signaling by FGFR1 in disease","Negative regulation of the PI3K/AKT network","Signaling by NTR
K1 (TRKA)","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","FGFR1 mutant receptor activation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signalling to ERKs","VEGFR2 mediated cell pro
liferation","VEGF binds to VEGFR leading to receptor dimerization","Signaling by activated point mutants of FGFR1","Signalling to RAS","p38MAPK events"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{su5402,215543-92-3,215543923,SU-5402,SU5402,"SU 5402",3-((3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE)-2-INDOLINONE,3((3(2CARBOXYETHYL)4METHYLPYRROL2YL)METHYLENE)2INDOLINONE,3-(3-(2-Carboxyethyl
)-4-methylpyrrol-2-methylidenyl)-2-indolinone,3(3(2Carboxyethyl)4methylpyrrol2methylidenyl)2indolinone,CHEMBL89363,3-((3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene)-2-indolinone,3((3(2carboxyethyl
)4methylpyrrol2yl)methylene)2indolinone,SY-SU-5402}

> <pdid>
PD004312

> <targets>
{FGFR}

> <classes>
{}

> <pubchem_cids>
{5289418}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 26  0  0  0  0            999 V2000
    2.5532   -4.4223    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7554    0.0000 C   0  0
   -3.8938   -2.2554    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -5.2029    2.9932    0.0000 O   0  0
   -6.4990    0.7409    0.0000 C   0  0
   -7.8007    1.4864    0.0000 C   0  0
   -9.0971    0.7319    0.0000 C   0  0
   -9.0919   -0.7681    0.0000 C   0  0
  -10.3884   -1.5226    0.0000 O   0  0
   -7.7903   -1.5136    0.0000 C   0  0
   -7.7851   -3.0136    0.0000 O   0  0
   -6.4939   -0.7591    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10  2  2  0
  7 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  3  0
 12 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 22 23  1  0
 22 24  2  0
 24 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28677

> <plate>
Kinase v5-2

> <well>
H08

> <supplier_cmpd_name>
AGL2263

> <ctcr_id>
1630

> <supplier_cmpd_id>
SY-AGL2263

> <smiles>
Oc1oc2ccc(cc2n1)C=C(C#N)C(=O)c3ccc(O)c(O)c3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"AGL 2263",SY-AGL2263,AGL2263}

> <pdid>

> <targets>
{}

> <classes>
{}

> <pubchem_cids>
{57370123}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.5496   -4.4224    0.0000 N   0  0
   -1.7973   -5.7210    0.0000 C   0  0
   -0.2973   -5.7184    0.0000 O   0  0
   -2.5450   -7.0224    0.0000 C   0  0
   -1.7950   -8.3214    0.0000 C   0  0
   -2.5450   -9.6205    0.0000 C   0  0
   -4.0450   -9.6206    0.0000 C   0  0
   -4.7951   -8.3216    0.0000 N   0  0
   -4.0451   -7.0225    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2985    3.7517    0.0000 F   0  0
   -1.2993    3.7504    0.0000 F   0  0
   -0.0007    4.5008    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 11 21  2  0
 21 22  1  0
 22  5  1  0
 22  9  1  0
  7 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28678

> <plate>
Kinase v5-2

> <well>
H10

> <supplier_cmpd_name>
S-99

> <ctcr_id>
4588

> <supplier_cmpd_id>
SY-S-99

> <smiles>
CC(C)Nc1cc(cc2nc(NC(=O)c3cccnc3)nn12)C(F)(F)F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{9,S-99,S99,1124381-69-6,1124381696,C16H15F3N6O,SCHEMBL2812561,CHEMBL3183131,SYN1119,BCP29577,LT0083,ZINC90408699,NCGC00345841-01,NCGC0034584101,NCGC00345841-02,NCGC0034584102,AS-16261,AS16261,"S 99; 
S99",X5890,SY-S-99}

> <pdid>

> <targets>
{ASK}

> <classes>
{}

> <pubchem_cids>
{59437537}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
   11.8498    3.9328    0.0000 C   0  0
   10.3498    3.9230    0.0000 C   0  0
    9.5901    5.2174    0.0000 C   0  0
   10.3335    6.5202    0.0000 C   0  0
    9.5769    7.8154    0.0000 N   0  0
    8.0769    7.8078    0.0000 C   0  0
    7.3335    6.5050    0.0000 N   0  0
    8.0900    5.2096    0.0000 C   0  0
    7.3442    3.9074    0.0000 N   0  0
    8.0987    2.6109    0.0000 C   0  0
    7.3533    1.3093    0.0000 C   0  0
    5.8532    1.3040    0.0000 N   0  0
    5.1047    0.0031    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.7248    1.2135    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 C   0  0
   -2.5998    3.0004    0.0000 F   0  0
   -3.8976    0.7500    0.0000 F   0  0
   -3.8982    2.2498    0.0000 F   0  0
    5.0987    2.6005    0.0000 C   0  0
    5.8442    3.9021    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 14  1  0
 17 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 16  1  0
 20 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
 12 27  1  0
 27 28  1  0
 28  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28679

> <plate>
Kinase v5-2

> <well>
H12

> <supplier_cmpd_name>
PF-4708671

> <ctcr_id>
11434

> <supplier_cmpd_id>
SY-PF-4708671

> <smiles>
CCc1cncnc1N1CCN(Cc2nc3c([nH]2)cc(cc3)C(F)(F)F)CC1

> <pd_targets>
{RPS6KB1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase RSK family","AGC protein kinase p70 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","RSK family","p70 subfamily"}

> <pathway_reactome>
{"Signal Transduction","MTOR signalling","mTORC1-mediated signalling"}

> <broad_targets>
{RPS6KB1}

> <broad_moa>
{"ribosomal protein inhibitor"}

> <synonyms>
{F470867,PF-4708671,PF4708671,1255517-76-0,1255517760,"PF 4708671",PF-04708671,PF04708671,MFCD18086922,C19H21F3N6,5FI,MLS006011193,GTPL8036,CHEMBL2134202,SCHEMBL17714406,AOB5417,DTXSID10680074,EX-A248
,EXA248,SYN1177,HMS3263P20,HMS3651E14,HMS3673K17,BCP07961,Tox21_501279,Tox21501279,Tox21-501279,"Tox21 501279",2644AH,s216,T2002}

> <pdid>
PD003285

> <targets>
{"p70 S6K"}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{51371303}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -4.9546    1.9903    0.0000 N   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.8193    4.6606    0.0000 C   0  0
   -6.2907    4.9251    0.0000 C   0  0
   -6.7982    6.3366    0.0000 C   0  0
   -5.8296    7.4819    0.0000 C   0  0
   -6.3371    8.8934    0.0000 Cl  0  0
   -4.3534    7.2156    0.0000 C   0  0
   -3.8459    5.8041    0.0000 C   0  0
   -2.7390    2.9810    0.0000 C   0  0
   -1.6193    3.9803    0.0000 C   0  0
   -0.1673    3.6256    0.0000 C   0  0
    0.8689    4.7101    0.0000 C   0  0
    0.4478    6.1498    0.0000 N   0  0
   -1.0096    6.5049    0.0000 C   0  0
   -2.0458    5.4204    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10  5  1  0
  8 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 15  1  0
 14 22  1  0
 22 11  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28680

> <plate>
Kinase v5-2

> <well>
H14

> <supplier_cmpd_name>
SD-06

> <ctcr_id>
3255

> <supplier_cmpd_id>
SY-SD-06

> <smiles>
OCC(=O)N1CCC(CC1)c2[nH]nc(c3ccc(Cl)cc3)c2c4ccncn4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{D0,SD-06,SD06,271576-80-8,271576808,SD-0006,SD0006,"SD 0006",UNII-C57VF8YO91,UNIIC57VF8YO91,C57VF8YO91,CHEMBL1090173,CHEBI:82712,"SD 06;SD06",3hl7,SCHEMBL4891685,SCHEMBL21067779,DTXSID60432080,SYN107
8,HMS3244I19,HMS3244I20,HMS3244J19,BCP21625,EX-A2504,EXA2504,ZINC6718469,4033AH,BDBM50315123,s6502,SY-SD-06}

> <pdid>

> <targets>
{"p38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{9865587}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 35  0  0  0  0            999 V2000
    7.7950   -1.5087    0.0000 O   0  0
    6.4971   -0.7566    0.0000 C   0  0
    6.4995    0.7434    0.0000 C   0  0
    5.2017    1.4955    0.0000 C   0  0
    3.9014    0.7475    0.0000 O   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 S   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.6837   -4.3363    0.0000 C   0  0
   -4.1755   -4.1795    0.0000 C   0  0
   -4.7856   -2.8092    0.0000 C   0  0
   -3.9040   -1.5957    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 C   0  0
    5.2040    2.9962    0.0000 N   0  0
    6.5031    3.7463    0.0000 C   0  0
    6.5031    5.2463    0.0000 C   0  0
    5.2040    5.9963    0.0000 O   0  0
    3.9050    5.2463    0.0000 C   0  0
    3.9050    3.7463    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 16  1  0
 24 19  1  0
  4 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28681

> <plate>
Kinase v5-2

> <well>
H16

> <supplier_cmpd_name>
KU57788    (NU7441)

> <ctcr_id>
4863

> <supplier_cmpd_id>
SY-KU57788

> <smiles>
O=C1C=C(Oc2c1cccc2c3cccc4c3sc5ccccc45)N6CCOCC6

> <pd_targets>
{PIK3CG,BRDT,BRD4,PRKDC,MTOR,PIK3CB,PIK3CA,PIK3CD,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Ion channel",Transferase,Reader,Kinase,"Voltage-gated ion channel",Bromodomain,"Protein Kinase","Potassium channels","Atypical protein kinase group","Voltage-gated pota
ssium channel","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Ion channels","Kinases (EC 2.7.x.x)","Bromodomain-containing proteins","Chromatin modifying enzymes","Voltage-gated ion channels","Lipid modifying kinases","Non-enzym
atic BRD containing proteins","Enzymatic bromodomain-containing proteins",Atypical,"Potassium channels",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Bromodomain kinase (BRDK) family","Phos
phatidyl inositol 3' kinase-related kinases (PIKK) family","Voltage-gated potassium channels","Other PIKK family kinases","FRAP subfamily"}

> <pathway_reactome>
{Metabolism,Disease,"Immune System","Gene expression (Transcription)","Signal Transduction","Muscle contraction","Metabolism of lipids","Infectious disease","Innate Immune System","RNA Polymerase II T
ranscription","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Immune system","Cardiac conduction","Ph
ospholipid metabolism","SARS-CoV Infections","Cytosolic sensors of pathogen-associated DNA","Generic Transcription Pathway","Signaling by Insulin receptor","Signaling by FGFR in disease","Signaling by
 Interleukins","Phase 3 - rapid repolarisation","PI Metabolism","Potential therapeutics for SARS","STING mediated induction of host immune responses","Transcriptional Regulation by TP53","Insulin rece
ptor signalling cascade","Signaling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Synthesis of PIPs at the plasma membrane","IRF3-mediated induction of type I IFN","Regulati
on of TP53 Activity","IRS-mediated signalling","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","Regulation of TP53 Expression and Degradation","PI3K Cascade","Signaling by cyto
solic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
{PRKDC}

> <broad_moa>
{"DNA dependent protein kinase inhibitor"}

> <synonyms>
{503468-95-9,503468959,NU7441,NU-7441,"NU 7441",KU-57788,KU57788,"NU7441 (KU-57788)","NU7441 (KU57788)",8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one,8(4Dibenzothienyl)2(4morpholinyl)4H
1benzopyran4one,NU-7432,NU7432,"KU 57788",8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one,8dibenzothiophen4yl2morpholin4ylchromen4one,8-dibenzothiophen-4-yl-2-morp,8dibenzothiophen4yl2morp,T6276,
SY-KU57788,S2638,"KU57788    (NU7441)"}

> <pdid>
PD010903

> <targets>
{DNA-PK,PI3K}

> <classes>
{"DNA Damage"}

> <pubchem_cids>
{11327430}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    8.1250   -8.9408    0.0000 O   0  0
    7.5170   -7.5696    0.0000 C   0  0
    6.0248   -7.4094    0.0000 C   0  0
    5.4165   -6.0373    0.0000 C   0  0
    4.8082   -4.6653    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    6.4437   -1.8466    0.0000 C   0  0
    7.3222   -3.0635    0.0000 C   0  0
    8.8153   -2.9121    0.0000 C   0  0
    9.6938   -4.1289    0.0000 C   0  0
   11.1864   -3.9798    0.0000 C   0  0
   12.0619   -5.1977    0.0000 C   0  0
   11.4449   -6.5649    0.0000 C   0  0
    9.9523   -6.7142    0.0000 C   0  0
    9.0768   -5.4962    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 N   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  3  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15  9  1  0
  8 16  2  0
 16 17  1  0
 17  6  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 16 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28682

> <plate>
Kinase v5-2

> <well>
H18

> <supplier_cmpd_name>
RWJ-67657

> <ctcr_id>
6291

> <supplier_cmpd_id>
SY-RWJ-67657

> <smiles>
OCCC#Cc1nc(c2ccc(F)cc2)c(n1CCCc3ccccc3)c4ccncc4

> <pd_targets>
{MAPK-1,MAPK14,MAPK11}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase ERK1","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK14,PTGS2}

> <broad_moa>
{"MAP kinase inhibitor"}

> <synonyms>
{WJ6765,RWJ-67657,RWJ67657,215303-72-3,215303723,"RWJ 67657","JNJ 3026582",C27H24FN3O,CHEMBL190333,SCHEMBL162010,DTXSID40175867,SYN1072,HMS3244I11,HMS3244I12,HMS3244J11,BCP01966,ZINC1546302,ABP000280,
BDBM50295553,AKOS024457373,RWJ-67657/RWJ67657,RWJ67657/RWJ67657,NCGC00241112-01,NCGC0024111201,N,SY-RWJ-67657}

> <pdid>
PD017418

> <targets>
{"p38 MAPK"}

> <classes>
{}

> <pubchem_cids>
{3008319}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
   -2.6933   -6.3162    0.0000 C   0  0
   -1.2256   -6.6258    0.0000 N   0  0
   -0.2234   -5.5086    0.0000 N   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Br  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -0.7600   -8.0526    0.0000 S   0  0
    0.2421   -6.9365    0.0000 O   0  0
    0.7077   -8.3622    0.0000 O   0  0
   -1.7622   -9.1698    0.0000 C   0  0
   -1.2960  -10.5955    0.0000 C   0  0
   -2.2976  -11.7121    0.0000 C   0  0
   -3.7654  -11.4030    0.0000 C   0  0
   -4.2316   -9.9773    0.0000 C   0  0
   -3.2300   -8.8607    0.0000 C   0  0
   -3.6962   -7.4350    0.0000 C   0  0
   -1.8341  -13.1396    0.0000 N   0  3
   -0.3668  -13.4513    0.0000 O   0  5
   -2.8373  -14.2548    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14  5  1  0
 14  8  1  0
  2 15  1  0
 15 16  2  0
 15 17  2  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 20 25  1  0
 25 26  1  0
 25 27  2  0
M  CHG  2  25   1  26  -1
M  END
> <name>
UTKinase_V5

> <id>
28683

> <plate>
Kinase v5-2

> <well>
H20

> <supplier_cmpd_name>
PIK-75

> <ctcr_id>
5272

> <supplier_cmpd_id>
SY-PIK-75

> <smiles>
CN(N=Cc1cnc2ccc(Br)cn12)[S](=O)(=O)c3cc(ccc3C)[N+]([O-])=O

> <pd_targets>
{PIK3CA,PIK3CD,CDK7,CDK9,PIK3CB,PIK3C2B,FLT3,CDK2,PIK3CG,GSK3B,PRKDC,CCNT1}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","CMGC protein kinase group","TK protein kinase group","Atypical protein kinase group","CMGC protein kinase CDK family","Tyrosine protein kinase PDGFR family
","CMGC protein kinase GSK family","Atypical protein kinase PIKK family","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases",Atypical,Phosphatidylinositol-4,"5-bisphosp
hate 3-kinase family","Cyclin-dependent kinase (CDK) family","Phosphatidylinositol-4-phosphate 3-kinase family","TK: Tyrosine kinase","Glycogen synthase kinase (GSK) family","Phosphatidyl inositol 3' 
kinase-related kinases (PIKK) family","CDK7 subfamily","CDK9 subfamily","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","GSK subfamily","Other PIKK family kinases","Type III RTKs: PDGFR",CSFR,Kit,
"FLT3 receptor family"}

> <pathway_reactome>
{Disease,"Immune System","Signal Transduction",Metabolism,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Im
mune system","Infectious disease","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","RNA Polymerase II Transcription","Innate Immune System","Signaling by FGFR in disease","Signaling by 
Interleukins","HIV Infection","Signaling by Insulin receptor","Phospholipid metabolism","Generic Transcription Pathway","SARS-CoV Infections","Cytosolic sensors of pathogen-associated DNA","Signaling 
by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","HIV Life Cycle","Insulin receptor signalling cascade","PI Metabolism","Transcriptional Regulation by TP53","SARS-CoV-1 Infectio
n","STING mediated induction of host immune responses","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","Late Phase of HIV Life Cycle","IRS-mediated signalling","Synthesis of PI
Ps at the plasma membrane","Regulation of TP53 Activity","SARS-CoV-1 Genome Replication and Transcription","IRF3-mediated induction of type I IFN","Signaling by cytosolic FGFR1 fusion mutants","Transc
ription of the HIV genome","PI3K Cascade","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-1 genome","HIV Transcription Elongation","Regulation of TP53 Degradation","Tat-me
diated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC}

> <broad_moa>
{"DNA protein kinase inhibitor","PI3K inhibitor"}

> <synonyms>
{372196-67-3,372196673,PIK-75,PIK75,"PIK-75 (hydrochloride)","PIK75 (hydrochloride)",HMS3244E07,HMS3244E08,HMS3244F07,ZINC33971596,AKOS026750590,NCGC00346500-01,NCGC0034650001,Q27166591,SY-PIK-75,"PIK
 75"}

> <pdid>
PD016738

> <targets>
{PIK75,"PI3K ALPHA",alpha,PIK3}

> <classes>
{}

> <pubchem_cids>
{56965896}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 F   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 F   0  0
    3.8975   -2.2510    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.5517    0.8722    0.0000 O   0  0
   -7.5554    1.9869    0.0000 C   0  0
   -6.8054    3.2859    0.0000 C   0  0
   -7.4120    4.6559    0.0000 C   0  0
   -6.5281    5.8688    0.0000 O   0  0
   -7.1357    7.2412    0.0000 C   0  0
   -6.2540    8.4547    0.0000 C   0  0
   -6.8641    9.8251    0.0000 C   0  0
   -8.3559    9.9819    0.0000 C   0  0
   -8.9691   11.3517    0.0000 C   0  0
  -10.4619   11.5065    0.0000 C   0  0
  -11.0751   12.8764    0.0000 C   0  0
  -12.5680   13.0312    0.0000 C   0  0
  -13.1812   14.4010    0.0000 N   0  0
  -14.6395   14.6930    0.0000 C   0  0
  -14.7962   16.1847    0.0000 C   0  0
  -13.4259   16.7948    0.0000 N   0  0
  -12.4222   15.6801    0.0000 N   0  0
   -9.2376    8.7684    0.0000 C   0  0
   -8.6275    7.3981    0.0000 C   0  0
   -5.3382    2.9741    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 25  1  0
 20 30  1  0
 30 31  2  0
 31 17  1  0
 14 32  1  0
 32 11  2  0
  8 33  1  0
 33 34  2  0
 34  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28684

> <plate>
Kinase v5-2

> <well>
H22

> <supplier_cmpd_name>
Mubritinib   (TAK-165)

> <ctcr_id>
4591

> <supplier_cmpd_id>
SY-Mubritinib

> <smiles>
FC(F)(F)c1ccc(C=Cc2occ(COc3ccc(CCCCn4ccnn4)cc3)n2)cc1

> <pd_targets>
{ERBB2,EGFR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction","Nervous system development","Signaling by GPCR","Axon guidance","GPCR downstream signalling","Semaphorin interactions","G alpha (q) signalling events","
Sema4D in semaphorin signaling","Gastrin-CREB signalling pathway via PKC and MAPK","Sema4D induced cell migration and growth-cone collapse","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR,ERBB2}

> <broad_moa>
{"protein tyrosine kinase inhibitor"}

> <synonyms>
{CHEMBL3186716,HMS3655P10,HMS3744I11,NCGC00346582-01,NCGC0034658201,AK326132,SY-Mubritinib,S2216,"Mubritinib   (TAK-165)","Mubritinib (TAK 165)"}

> <pdid>
PD010822

> <targets>
{HER2}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{204100}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -3.8933    3.7570    0.0000 C   0  0
   -3.8912    5.2578    0.0000 C   0  0
   -5.1894    6.0109    0.0000 C   0  0
   -5.1895    7.5109    0.0000 C   0  0
   -6.4885    8.2609    0.0000 C   0  0
   -7.7876    7.5110    0.0000 C   0  0
   -7.7876    6.0110    0.0000 C   0  0
   -6.4886    5.2609    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
  5 16  1  0
 16 17  1  0
 16 18  2  0
 18  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28685

> <plate>
Kinase v5-2

> <well>
J04

> <supplier_cmpd_name>
JSH-23

> <ctcr_id>
1707

> <supplier_cmpd_id>
SY-JSH-23

> <smiles>
Cc1ccc(NCCCc2ccccc2)c(N)c1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{RELA}

> <broad_moa>
{"NFkB pathway inhibitor"}

> <synonyms>
{SH2,JSH-23,JSH23,749886-87-1,749886871,"4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine","4MethylN1(3phenylpropyl)benzene1,2diamine","JSH 23","4-Methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine","4Meth
yl1N(3phenylpropyl)benzene1,2diamine","4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine","4MethylN1(3phenylpropyl)1,2phenylenediamine","NF-kappaB Activation Inhibitor II, JSH-23","NFkappaB Activation
 Inhibitor II, JSH23",NFKB-activation-i,NFKBactivationi,T1930,SY-JSH-23,S7351}

> <pdid>
PD010342

> <targets>
{"Nf-kappa nuclear translocation",NF-?B,NF-??B,NF-ºB}

> <classes>
{NF-?B,NF-ºB}

> <pubchem_cids>
{16760588}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 N   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0875    3.7680    0.0000 O   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -5.1930    3.0045    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  2  0
 17 11  1  0
  9 18  2  0
 18  5  1  0
 18 19  1  0
 19 20  2  0
 20  3  1  0
 20 21  1  0
 21 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28686

> <plate>
Kinase v5-2

> <well>
J06

> <supplier_cmpd_name>
WHI-P131 (JAK3 Inhibitor 1)

> <ctcr_id>
6128

> <supplier_cmpd_id>
SY-WHI-P131

> <smiles>
COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC

> <pd_targets>
{RET,LCK,ALK,EGFR,KDR,JAK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Tyrosine protein kinase Ret family","Tyrosine protein kinase Src family","TKL protein kinase STKR family","Tyrosin
e protein kinase EGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase JakA family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type XIV RTKs: RET","Src family","Type XIX RTKs: L
eukocyte tyrosine kinase (LTK) receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Janus kinase (J
akA) family"}

> <pathway_reactome>
{"Developmental Biology",Disease,"Signal Transduction","Immune System","Nervous system development","Infectious disease","Signaling by GPCR","Signaling by Receptor Tyrosine Kinases","Cytokine Signalin
g in Immune system","Axon guidance","HIV Infection","GPCR downstream signalling","Signaling by VEGF","Signaling by Interleukins","RET signaling","Host Interactions of HIV factors","G alpha (q) signall
ing events","VEGFA-VEGFR2 Pathway","Interleukin-2 family signaling","The role of Nef in HIV-1 replication and disease pathogenesis","Gastrin-CREB signalling pathway via PKC and MAPK","VEGFR2 mediated 
cell proliferation","Interleukin-15 signaling","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","EGFR Transactivation by Gastrin","Nef Mediated CD4 Down
-regulation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"HIP131 (JAK3 INHIBITOR 1",JANEX-1,JANEX1,202475-60-3,202475603,WHI-P131,WHIP131,"jak3 inhibitor i","4-(6,7-dimethoxyquinazolin-4-ylamino)phenol","4(6,7dimethoxyquinazolin4ylamino)phenol","4-((6,7-di
methoxyquinazolin-4-yl)amino)phenol","4((6,7dimethoxyquinazolin4yl)amino)phenol","Janex 1",CHEMBL405130,"4-((6,7-dimethoxy-4-quinazolinyl)amino)-phenol","4((6,7dimethoxy4quinazolinyl)amino)phenol",Phe
nol,4-,4,T2045,SY-WHI-P131,"WHI-P131 (JAK3 Inhibitor 1)"}

> <pdid>
PD012567

> <targets>
{JAK3,JAK}

> <classes>
{Epigenetics,JAK/STAT Signaling,Stem Cell/Wnt}

> <pubchem_cids>
{3794}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    5.1852    3.0091    0.0000 Br  0  0
    5.1903    1.5091    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0049   -5.9994    0.0000 C   0  0
    1.3026   -5.2471    0.0000 O   0  0
    0.0080   -7.5002    0.0000 C   0  0
    1.3081   -8.2484    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  2  0
 15 21  1  0
 21 22  2  0
 22  8  1  0
 22 12  1  0
  6 23  2  0
 23  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28687

> <plate>
Kinase v5-2

> <well>
J10

> <supplier_cmpd_name>
PD168393

> <ctcr_id>
3834

> <supplier_cmpd_id>
SY-PD168393

> <smiles>
Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1

> <pd_targets>
{EGFR,FYN,BTK,SRC,ERBB4,JAK3,BMX,ERBB2,BLK,ERBB3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Tec family","Tyrosine protein kinase JakA 
family","Tyrosine protein kinase SrcA"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type I RTKs: ErbB (epidermal growth factor) recept
or family","Src family","Tec family","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Neuronal System","Immune System",Metabolism,"Developmental Biology","Gene expression (Transcription)","Signaling by GPCR","Infectious disease","Signaling by Receptor Ty
rosine Kinases","Transmission across Chemical Synapses","Cytokine Signaling in Immune system","Metabolism of lipids","Nervous system development","RNA Polymerase II Transcription","GPCR downstream sig
nalling","HIV Infection","Leishmania infection","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by Interleukins","Phospholipid metabolism","Axon guida
nce","Generic Transcription Pathway","G alpha (q) signalling events","Host Interactions of HIV factors","Parasite infection","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic 
events","Interleukin-2 family signaling","PI Metabolism","Semaphorin interactions","Transcriptional regulation by RUNX1","Gastrin-CREB signalling pathway via PKC and MAPK","The role of Nef in HIV-1 re
plication and disease pathogenesis","Leishmania phagocytosis","Signalling to ERKs","Post NMDA receptor activation events","Interleukin-15 signaling","Synthesis of PIPs at the plasma membrane","Sema4D 
in semaphorin signaling","RUNX1 regulates transcription of genes involved in BCR signaling","EGFR Transactivation by Gastrin","Nef and signal transduction","FCGR3A-mediated phagocytosis","Signalling t
o RAS","Long-term potentiation","Sema4D induced cell migration and growth-cone collapse","p38MAPK events"}

> <broad_targets>
{EGFR,ERBB2,SRC}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{194423-15-9,194423159,PD168393,PD-168393,"pd 168393",4-((3-Bromophenyl)amino)-6-acrylamidoquinazoline,4((3Bromophenyl)amino)6acrylamidoquinazoline,UNII-3R996Y9T0I,UNII3R996Y9T0I,n-(4-((3-bromophenyl)
amino)quinazolin-6-yl)prop-2-enamide,n(4((3bromophenyl)amino)quinazolin6yl)prop2enamide,N-(4-(3-bromoanilino)quinazolin-6-yl)prop-2-enamide,N(4(3bromoanilino)quinazolin6yl)prop2enamide,N-(4-((3-bromop
henyl)amino)quin,N(4((3bromophenyl)amino)quin,T6932,SY-PD168393,S7039}

> <pdid>
PD005576

> <targets>
{EGFR,PTK}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{4708}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 29  0  0  0  0            999 V2000
    7.7965   -1.5150    0.0000 C   0  0
    6.4990   -0.7623    0.0000 C   0  0
    6.5025    0.7377    0.0000 C   0  0
    7.7997   -0.0152    0.0000 C   0  0
    5.1972   -1.5092    0.0000 N   0  0
    3.8990   -0.7562    0.0000 C   0  0
    3.9026    0.7438    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 N   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -2.5795   -7.5040    0.0000 F   0  0
   -1.2883   -5.2495    0.0000 C   0  0
    0.0156   -5.9927    0.0000 N   0  0
    1.3117   -5.2360    0.0000 C   0  0
    1.3039   -3.7360    0.0000 C   0  0
    0.0089   -4.4925    0.0000 C   0  0
    2.6156   -5.9792    0.0000 C   0  0
    3.9109   -5.2229    0.0000 O   0  0
   -1.2935   -3.7495    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 22 25  1  0
 25 26  1  0
 20 27  2  0
 27 15  1  0
 13 28  2  0
 28  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28688

> <plate>
Kinase v5-2

> <well>
J12

> <supplier_cmpd_name>
Bayer-18

> <ctcr_id>
6199

> <supplier_cmpd_id>
SY-Bayer18

> <smiles>
CC(C)(C)NC(=O)Nc1cccc(Nc2ncc(F)c(NC(C)(C)CO)n2)c1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{AYER1,Bayer-18,Bayer18,1251752-12-1,1251752121,"Bayer18;Bayer 18",SCHEMBL16156862,C19H27FN6O2,SYN1130,BCP21620,ZINC95627126,NCGC00345844-01,NCGC0034584401,NCGC00345844-02,NCGC0034584402,NCGC00345844-
03,NCGC0034584403,AS-16269,AS16269,SY-Bayer18}

> <pdid>

> <targets>
{TYK2}

> <classes>
{}

> <pubchem_cids>
{73265273}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    6.8167   -0.8257    0.0000 C   0  0
    6.3509   -2.2515    0.0000 C   0  0
    7.3532   -3.3675    0.0000 O   0  0
    4.8823   -2.5608    0.0000 O   0  0
    3.8794   -1.4442    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    4.0417   -4.4401    0.0000 C   0  0
    4.9463   -3.2436    0.0000 O   0  0
    4.4671   -5.8785    0.0000 N   0  0
    3.2311   -6.7270    0.0000 C   0  0
    3.0348   -8.2141    0.0000 C   0  0
    1.6487   -8.7875    0.0000 C   0  0
    1.4523  -10.2746    0.0000 Br  0  0
    0.4590   -7.8739    0.0000 C   0  0
    0.6554   -6.3869    0.0000 C   0  0
    2.0415   -5.8134    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12  7  1  0
 12 13  2  3
 13 14  1  0
 14  6  1  0
 14 15  2  3
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 21 23  2  0
 23 24  1  0
 24 25  2  0
 25 15  1  0
 25 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28689

> <plate>
Kinase v5-2

> <well>
J14

> <supplier_cmpd_name>
BIO-Ac (GSK-3 Inhibitor X)

> <ctcr_id>
2285

> <supplier_cmpd_id>
SY-BIO-Ac

> <smiles>
CC(=O)ONC1=C2C=CC=CC2=NC1=C3C(=O)Nc4cc(Br)ccc34

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"BIO-Ac (GSK-3 Inhibitor X)",SY-BIO-Ac}

> <pdid>
PD046995

> <targets>
{GSK-3alpha/beta}

> <classes>
{}

> <pubchem_cids>
{24906283}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 24  0  0  0  0            999 V2000
    4.8903  -10.1311    0.0000 C   0  0
    5.5071   -8.7638    0.0000 C   0  0
    6.9997   -8.6148    0.0000 C   0  0
    4.6332   -7.5468    0.0000 C   0  0
    5.1017   -6.1218    0.0000 S   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7545    0.0000 C   0  0
   -5.1996    1.4928    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.6747   -6.1134    0.0000 N   0  0
    3.1332   -7.5416    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 15 20  1  0
 20 21  2  0
 21 12  1  0
  6 22  2  0
 22 23  1  0
 23  4  2  0
M  END
> <name>
UTKinase_V5

> <id>
28690

> <plate>
Kinase v5-2

> <well>
J08

> <supplier_cmpd_name>
PHA690509

> <ctcr_id>
4243

> <supplier_cmpd_id>
SY-PHA690509

> <smiles>
CC(C)c1sc(NC(=O)C(C)c2ccc(NC(C)=O)cc2)nc1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SCHEMBL5726403,CHEMBL2143507,HMS3244M05,HMS3244M06,HMS3244N05,"2-(4-acetamidophenyl)-N-(5-propan-2-yl-1,3-thiazol-2-yl)propanamide","2(4acetamidophenyl)N(5propan2yl1,3thiazol2yl)propanamide",SY-PHA69
0509,PHA690509}

> <pdid>
PD161799

> <targets>
{CDK}

> <classes>
{}

> <pubchem_cids>
{9923630}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8891   -6.7578    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -6.4939    0.7411    0.0000 N   0  0
   -6.4894   -0.7597    0.0000 C   0  0
   -7.7846   -1.5163    0.0000 C   0  0
   -7.7770   -3.0163    0.0000 C   0  0
   -6.4742   -3.7597    0.0000 C   0  0
   -5.1790   -3.0032    0.0000 C   0  0
   -5.1866   -1.5032    0.0000 C   0  0
   -6.4667   -5.2605    0.0000 N   0  0
   -7.7607   -6.0192    0.0000 C   0  0
   -7.7507   -7.5192    0.0000 C   0  0
   -6.4467   -8.2605    0.0000 O   0  0
   -5.1527   -7.5019    0.0000 C   0  0
   -5.1627   -6.0019    0.0000 C   0  0
   -3.8967    0.7484    0.0000 N   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  3  0
  2  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 10 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 22 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 25  1  0
 17 31  2  0
 31 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28691

> <plate>
Kinase v5-2

> <well>
J16

> <supplier_cmpd_name>
CYT387

> <ctcr_id>
6247

> <supplier_cmpd_id>
SY-CYT387

> <smiles>
O=C(NCC#N)c1ccc(cc1)c2ccnc(Nc3ccc(cc3)N4CCOCC4)n2

> <pd_targets>
{JAK2,JAK3,ACVR1,JAK1,BMPR1B,TGFBR1,BMPR1A}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Tyrosine protein kinase JakA family","TKL protein kinase STKR family","TKL protein kinase STKR1","TKL protein kina
se STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Non-receptor tyrosine kinases (nRTKs)","Receptor serine/threonine kinase (RSTK) family","Janus ki
nase (JakA) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{"Cell Cycle","Immune System","Signal Transduction",Disease,Mitotic,"Cytokine Signaling in Immune system","Signaling by TGFB family members","Diseases of signal transduction by growth factor receptors
 and second messengers","Mitotic G1 phase and G1/S transition","Signaling by Interleukins","Interferon Signaling","Signaling by BMP","Signaling by TGF-beta Receptor Complex in Cancer","G1 Phase","Inte
rleukin-2 family signaling","Antiviral mechanism by IFN-stimulated genes","Loss of Function of SMAD2/3 in Cancer","Cyclin D associated events in G1","Interleukin-15 signaling","ISG15 antiviral mechani
sm","SMAD2/3 Phosphorylation Motif Mutants in Cancer"}

> <broad_targets>
{JAK1,JAK2,JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{Cyt387,1056634-68-4,1056634684,MOMELOTINIB,Cyt-387,"CYT 387",N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide,N(Cyanomethyl)4(2((4morpholinophenyl)amino)pyrimidin4yl)benzamide
,"CYT 11387",UNII-6O01GMS00P,UNII6O01GMS00P,N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide,N(cyanomethyl)4(2(4morpholinophenylamino)pyrimidin4yl)benzamide,"Momelotinib free bas
",T1849,S2219,SY-CYT387,Momelotinib,momelotinib,CYT387}

> <pdid>
PD003635

> <targets>
{JAK2,JAK1,JAK,Apoptosis,Autophagy}

> <classes>
{JAK/STAT,Apoptosis,Autophagy,Epigenetics,JAK/STAT Signaling,Stem Cell/Wnt}

> <pubchem_cids>
{25062766}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    9.8970    5.1387    0.0000 C   0  0
   10.8104    3.9489    0.0000 C   0  0
    9.3959    3.8084    0.0000 C   0  0
    8.2035    2.8969    0.0000 C   0  0
    8.3970    1.4094    0.0000 O   0  0
    6.8176    3.4729    0.0000 N   0  0
    5.6273    2.5630    0.0000 C   0  0
    4.1890    2.9887    0.0000 N   0  0
    3.3397    1.7523    0.0000 C   0  0
    4.2568    0.5878    0.0000 C   0  0
    5.6669    1.0635    0.0000 S   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
    2.5981    1.5000    0.0000 Cl  0  0
    4.8054   -4.6666    0.0000 C   0  0
    3.9200   -5.8774    0.0000 F   0  0
    6.2966   -4.8284    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  1  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11  7  1  0
 10 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  3
 15 16  1  0
 16 12  1  0
 16 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 21  1  0
 21 22  2  3
 22 17  1  0
 22 23  1  0
 18 24  1  0
 14 25  1  0
 25 26  1  0
 25 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28692

> <plate>
Kinase v5-2

> <well>
J18

> <supplier_cmpd_name>
BMS-3

> <ctcr_id>
7727

> <supplier_cmpd_id>
SY-BMS-3

> <smiles>
C1CC1C(=O)NC2=NC=C(S2)C3=CC(=NN3C4=C(C=CC=C4Cl)Cl)C(F)F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MS,BMS-3,BMS3,1338247-30-5,1338247305,C17H12Cl2F2N4OS,CHEMBL3182065,EX-A935,EXA935,SYN1023,BCP17224,MFCD17019326,ZINC72232825,AKOS030526418,CS-5616,CS5616,NCGC00345825-01,NCGC0034582501,NCGC00345825-
02,NCGC0034582502,NCGC00345825-03,NCGC0034582503,AK547235,AS-16194,AS16194,HY-18304,HY18304,FT-0700441,FT0700441,J-523082,J523082,SY-BMS-3}

> <pdid>
PD016994

> <targets>
{LIMK}

> <classes>
{}

> <pubchem_cids>
{73265272}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
   11.3674  -11.3569    0.0000 C   0  0
   10.6553  -10.0368    0.0000 N   0  0
   11.4429   -8.7602    0.0000 C   0  0
    9.1551   -9.9924    0.0000 C   0  0
    8.4426   -8.6715    0.0000 C   0  0
    6.9424   -8.6271    0.0000 O   0  0
    6.2299   -7.3062    0.0000 C   0  0
    4.7306   -7.2597    0.0000 C   0  0
    4.0212   -5.9381    0.0000 C   0  0
    4.8092   -4.6676    0.0000 C   0  0
    6.3104   -4.7094    0.0000 C   0  0
    7.0198   -6.0310    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.1905    2.6376    0.0000 N   0  0
   -4.6581    2.9476    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 N   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 10 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 19  1  0
 23 24  2  3
 24 25  1  0
 20 26  2  0
 26 16  1  0
 15 27  2  0
 27 28  1  0
 28 13  2  0
 27 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28693

> <plate>
Kinase v5-2

> <well>
J20

> <supplier_cmpd_name>
SB590885

> <ctcr_id>
659

> <supplier_cmpd_id>
SY-SB-590885

> <smiles>
CN(C)CCOc1ccc(cc1)c2[nH]c(c3ccc4c(CCC4=NO)c3)c(n2)c5ccncc5

> <pd_targets>
{BRAF,RAF1,RIPK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase RAF family","TKL protein kinase RIPK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","RAF family","Receptor interacting protein kinase (RIPK) family"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","Innate Immune System","Signaling by NTRKs","MAPK1/MAPK3 signaling","Toll-like Receptor
 Cascades","Signaling by NTRK1 (TRKA)","RAF/MAP kinase cascade","Toll Like Receptor 5 (TLR5) Cascade","Signalling to ERKs","Negative regulation of MAPK pathway","MyD88 cascade initiated on plasma memb
rane","Prolonged ERK activation events","Negative feedback regulation of MAPK pathway","MAP kinase activation","ARMS-mediated activation","activated TAK1 mediates p38 MAPK activation"}

> <broad_targets>
{BRAF}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{405554-55-4,405554554,UNII-ISE5ATW631,UNIIISE5ATW631,SB-590885,SB590885,ISE5ATW631,CHEMBL1891617,C27H27N5O2,SB-590885-AAD,SB590885AAD,GTPL9389,SYN1077,CHEBI:131880,HMS3244C05,HMS3244C06,HMS3244D05,HM
S3265I03,HMS3265I04,HMS3265J03,HMS3265J04,HMS3655F12,BCP01889,AKOS024457220,ZINC1107870,SY-SB-590885,S2220}

> <pdid>
PD010819

> <targets>
{B-Raf,Raf}

> <classes>
{MAPK}

> <pubchem_cids>
{135564599}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 33  0  0  0  0            999 V2000
    9.9949    2.8884    0.0000 C   0  0
    9.3803    1.5201    0.0000 C   0  0
    7.8873    1.3671    0.0000 S   0  0
    7.0092    2.5832    0.0000 O   0  0
    8.5012    2.7357    0.0000 O   0  0
    7.2749    0.0036    0.0000 N   0  0
    5.8727   -0.5294    0.0000 C   0  0
    6.4440   -1.8462    0.0000 C   0  0
    7.3224   -3.0632    0.0000 C   0  0
    8.8156   -2.9119    0.0000 C   0  0
   10.3080   -2.7606    0.0000 N   0  0
    7.8079   -1.3985    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   12.8095   -0.9528    0.0000 O   0  0
   14.1088   -0.2033    0.0000 P   0  0
   15.4080   -0.9528    0.0000 O   0  0
   14.1088    1.2967    0.0000 O   0  0
   14.1088   -1.7033    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  2  0
  3  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  3  0
  8 12  1  0
 12  6  1  0
  8 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 13  1  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 18  1  0
 26 22  2  0
 27 28  1  0
 28 29  2  0
 28 30  1  0
 28 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28694

> <plate>
Kinase v5-2

> <well>
J22

> <supplier_cmpd_name>
INCB424-Analogue

> <ctcr_id>
202

> <supplier_cmpd_id>
SY-INCB424-Analogue

> <smiles>
CCS(=O)(=O)N1CC(CC#N)(C1)n2cc(cn2)c3ncnc4[nH]ccc34.OP(=O)(O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NCB424ANALOGU,"Baricitinib phosphate",1187595-84-1,1187595841,"Baricitinib (phosphate)","Baricitinib phosphate salt","1187595-84-1 (phosphate)","1187595841 (phosphate)",UNII-XIB47S8NNB,UNIIXIB47S8NNB
,XIB47S8NNB,INCB-28050,INCB28050,SCHEMBL871037,DTXSID30657980,SYN1117,C16H17N7O2S.H3PO4,BCP15527,HY-1531,HY1531,T2360,SY-INCB424-Analogue,Baricitinib Phosphate,INCB424-Analogue}

> <pdid>

> <targets>
{JAK,JAK2,JAK1}

> <classes>
{}

> <pubchem_cids>
{44231848}

$$$$
UTKinase_V5
  SciTegic11012413002D

 15 15  0  0  0  0            999 V2000
    5.1937   -3.0093    0.0000 O   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.1996    1.4928    0.0000 Br  0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28695

> <plate>
Kinase v5-2

> <well>
L04

> <supplier_cmpd_name>
PTP-3

> <ctcr_id>
6892

> <supplier_cmpd_id>
SY-PTP-3

> <smiles>
OC(=O)COc1ccc(cc1)C(=O)CBr

> <pd_targets>
{PTPN1}

> <pathway_gtopdb>
{Enzyme,Phosphatase,"Protein Phosphatase","Tyrosine protein phosphatase"}

> <pathway_chembl>
{Enzymes,Phosphatases,"Protein tyrosine phosphatases non-receptor type (PTPN)"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by MECP2","MECP2 regulates neuronal receptors and channels"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{TP,"PTP Inhibitor III",29936-81-0,29936810,"2-(4-(2-bromoacetyl)phenoxy)acetic Acid","2(4(2bromoacetyl)phenoxy)acetic Acid",CHEMBL104927,"2-(4-(2-bromoacetyl)phenoxy)acetic acid","2(4(2bromoacetyl)ph
enoxy)acetic acid","4-(Carboxymethoxy)phenacyl Br","4(Carboxymethoxy)phenacyl Br","4-(bromoacetyl)phenoxyacetic acid","4(bromoacetyl)phenoxyacetic acid","(4-(bromoacetyl)phenoxy)acetic acid","(4(bromo
acetyl)phenoxy)acetic acid","protein tyrosi",SY-PTP-3,PTP-3}

> <pdid>
PD044729

> <targets>
{PTP/SHP-1}

> <classes>
{}

> <pubchem_cids>
{4966}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 22  0  0  0  0            999 V2000
    5.0987    1.4988    0.0000 Cl  0  0
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -3.8978    3.7504    0.0000 C   0  0
   -3.9003    5.2504    0.0000 C   0  0
   -5.2005    5.9983    0.0000 C   0  0
   -6.4984    5.2463    0.0000 C   0  0
   -7.7986    5.9942    0.0000 O   0  0
   -6.4960    3.7463    0.0000 C   0  0
   -7.7938    2.9942    0.0000 O   0  0
   -5.1957    2.9983    0.0000 C   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 10 11  1  0
 11 12  2  0
 12  3  1  0
 12 13  1  0
  8 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 19 21  2  0
 21 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28696

> <plate>
Kinase v5-2

> <well>
L06

> <supplier_cmpd_name>
AG1433

> <ctcr_id>
1514

> <supplier_cmpd_id>
SY-AG1433

> <smiles>
Cl.Cc1cc2ncc(nc2cc1C)c3ccc(O)c(O)c3

> <pd_targets>
{CSF1R,PDGFRA,PDGFRB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by VENTX"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"SU 1433","AG 1433","2-(3,4-Dihydroxyphenyl)-6,7-dimethylquinoxaline, HCl","2(3,4Dihydroxyphenyl)6,7dimethylquinoxaline, HCl","4-(6,7-Dimethylquinoxalin-2-yl)benzene-1,2-diol hydrochloride","4(6,7Dim
ethylquinoxalin2yl)benzene1,2diol hydrochloride",SY-AG1433,AG1433}

> <pdid>
PD127565

> <targets>
{"PDGF-ß receptor kinase & KDR/Flk-1/VEGF Receptor 2 kinase"}

> <classes>
{}

> <pubchem_cids>
{135665295}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 24  0  0  0  0            999 V2000
    9.7860   -6.6602    0.0000 H   0  3
    7.2860   -6.6602    0.0000 Cl  0  5
    4.0497   -4.4250    0.0000 O   0  0
    2.5497   -4.4224    0.0000 C   0  0
    1.7974   -5.7210    0.0000 N   0  0
    2.5451   -7.0223    0.0000 C   0  0
    1.7928   -8.3210    0.0000 C   0  0
    2.5405   -9.6223    0.0000 C   0  0
    1.7882  -10.9210    0.0000 C   0  0
    2.5359  -12.2223    0.0000 N   0  0
    1.7859  -13.5214    0.0000 C   0  0
    2.5359  -14.8204    0.0000 C   0  0
    4.0359  -14.8205    0.0000 O   0  0
    4.7860  -13.5215    0.0000 C   0  0
    4.0360  -12.2224    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 10  1  0
  4 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 16  2  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28697

> <plate>
Kinase v5-2

> <well>
L08

> <supplier_cmpd_name>
CL82198

> <ctcr_id>
1485

> <supplier_cmpd_id>
SY-CL82198

> <smiles>
[H+].[Cl-].O=C(NCCCCN1CCOCC1)c2oc3ccccc3c2

> <pd_targets>
{MMP13}

> <pathway_gtopdb>
{Enzyme,Protease,"Metallo protease","Metallo protease MAM clan","Metallo protease M10A subfamily"}

> <pathway_chembl>
{Enzymes,"Peptidases and proteinases","MA: Metallo (M) Peptidases","M10: Matrix metallopeptidase"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional regulation by RUNX2","RUNX2 regulates genes involved in cell migration"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"CL 82198 hydrochloride",1188890-36-9,1188890369,"N-(4-morpholinobutyl)benzofuran-2-carboxamide hydrochloride","N(4morpholinobutyl)benzofuran2carboxamide hydrochloride",N-(4-morpholin-4-ylbutyl)-1-be
nzofuran-2-carboxamide;hydrochloride,N(4morpholin4ylbutyl)1benzofuran2carboxamide;hydrochloride,"N-(4-(4-Morpholinyl)butyl)-2-benzofurancarboxamide hydrochlori","N(4(4Morpholinyl)butyl)2benzofurancarb
oxamide hydrochlori",SY-CL82198,CL82198}

> <pdid>
PD018150

> <targets>
{MMP-13}

> <classes>
{}

> <pubchem_cids>
{16760373}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    1.8019   -5.7196    0.0000 C   0  0
    2.5524   -4.4208    0.0000 C   0  0
    3.3017   -5.7202    0.0000 C   0  0
    4.0524   -4.4217    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5987   -1.5004    0.0000 N   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 O   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 S   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 N   0  0
   -0.0048    6.0009    0.0000 C   0  0
   -0.0072    7.5009    0.0000 N   0  0
   -1.3026    5.2488    0.0000 N   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 12  1  0
 11 18  2  0
 18  7  1  0
 18 19  1  0
 19  5  1  0
  9 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28698

> <plate>
Kinase v5-2

> <well>
L10

> <supplier_cmpd_name>
GNE-493

> <ctcr_id>
6069

> <supplier_cmpd_id>
SY-GNE-493

> <smiles>
CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)c4cnc(N)nc4

> <pd_targets>
{PIK3CA,PIK3CD,SYK,MAP3K9,PIK3CB,MTOR,PIK3CG}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Atypical protein kinase group","Tyrosine protein kinase Syk family","TKL protein kinase MLK family","A
typical protein kinase PIKK family","TKL protein kinase MLK subfamily","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","Receptor kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","TK: Tyrosine kinase","TKL
: Tyrosine kinase-like","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Non-receptor tyrosine kinases (nRTKs)","Mixed Lineage Kinase (MLK) family","FRAP subfamily","Syk family","MLK s
ubfamily"}

> <pathway_reactome>
{Disease,"Immune System","Signal Transduction","Gene expression (Transcription)",Metabolism,"Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Im
mune system","Infectious disease","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Metabolism of lipids","Signaling by FGFR in disease","Signaling by Interleukins","Leishman
ia infection","Signaling by Insulin receptor","Generic Transcription Pathway","Phospholipid metabolism","Signaling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Leishmania p
arasite growth and survival","Insulin receptor signalling cascade","Transcriptional Regulation by TP53","PI Metabolism","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","Anti-in
flammatory response favouring Leishmania parasite infection","IRS-mediated signalling","Regulation of TP53 Activity","Synthesis of PIPs at the plasma membrane","Signaling by cytosolic FGFR1 fusion mut
ants","FCGR3A-mediated IL10 synthesis","PI3K Cascade","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NE49,GNE-493,GNE493,1033735-94-2,1033735942,UNII-0L843LS9YK,UNII0L843LS9YK,0L843LS9YK,CHEMBL1084926,SCHEMBL4438862,SYN1115,HMS3244E03,HMS3244E04,HMS3244F03,AOB87746,BCP06045,EX-A1073,EXA1073,BDBM5031
2613,MFCD18251526,s6517,ZINC43208700,AKOS030526212,CS-3358,CS3358,NCGC00345838-01,NCGC0034583801,NCGC00345838,SY-GNE-493}

> <pdid>
PD102636

> <targets>
{"pan PI3K/mTOR"}

> <classes>
{}

> <pubchem_cids>
{25242324}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
    6.4983   -0.7414    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2029   -2.9932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0049   -5.9994    0.0000 C   0  0
    0.0102   -7.4994    0.0000 C   0  0
    1.3118   -8.2449    0.0000 C   0  0
    1.3170   -9.7449    0.0000 F   0  0
    2.6082   -7.4904    0.0000 C   0  0
    3.9099   -8.2359    0.0000 O   0  0
    2.6030   -5.9904    0.0000 C   0  0
    3.8995   -5.2359    0.0000 F   0  0
    1.3014   -5.2449    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 20 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  1  0
 24 26  2  0
 26 18  1  0
 16 27  1  0
 27 28  2  0
 28  6  1  0
 28 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28699

> <plate>
Kinase v5-2

> <well>
L12

> <supplier_cmpd_name>
BI-D1870

> <ctcr_id>
4314

> <supplier_cmpd_id>
SY-BI-D1870

> <smiles>
CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12

> <pd_targets>
{RPS6KA6,CSNK1A1,RPS6KA1,RPS6KA2,RPS6KA3,JAK2,VRK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","CK1 protein kinase group","TK protein kinase group","AGC protein kinase RSK family","CK1 protein kinase CK1 family","Tyrosine protein kinase
 JakA family","CK1 protein kinase VRK family","AGC protein kinase RSK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase 1","Receptor kinases","RSK family","Casein kinase 1 (CK1) family","TK: Tyro
sine kinase","Vaccina related kinase (VRK) family","RSK subfamily","Non-receptor tyrosine kinases (nRTKs)","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Neuronal System",Disease,"Immune System","Cell Cycle","Transmission across Chemical Synapses","Diseases of signal transduction by growth factor receptors and second messengers","Innate Immune System
",Mitotic,"Neurotransmitter receptors and postsynaptic signal transmission","Signaling by WNT in cancer","Toll-like Receptor Cascades","Mitotic G1 phase and G1/S transition","M Phase","Activation of N
MDA receptors and postsynaptic events","Signaling by AMER1 mutants","Toll Like Receptor 5 (TLR5) Cascade","G1 Phase","Mitotic Metaphase and Anaphase","Post NMDA receptor activation events","Truncation
s of AMER1 destabilize the destruction complex","MyD88 cascade initiated on plasma membrane","Cyclin D associated events in G1","Mitotic Anaphase","CREB1 phosphorylation through NMDA receptor-mediated
 activation of RAS signaling","MAP kinase activation","Nuclear Envelope (NE) Reassembly","RSK activation","MAPK targets/ Nuclear events mediated by MAP kinases","Initiation of Nuclear Envelope (NE) Re
formation","CREB phosphorylation"}

> <broad_targets>
{RPS6KA1,RPS6KA2,RPS6KA3,RPS6KA6}

> <broad_moa>
{"ribosomal protein inhibitor"}

> <synonyms>
{BI-D1870,BID1870,501437-28-1,501437281,C19H23F2N5O2,cc-687,cc687,CHEMBL573107,GTPL8038,SCHEMBL13881333,BDBM25017,DTXSID40648506,SYN1020,BCPP000343,HMS3244C11,HMS3244C12,HMS3244D11,HMS3651D17,HMS3674C
15,BCP01977,EX-A2471,EXA2471,ABP000282,BI-D-1870,MFCD11223662,NSC747342,s2,T6171,SY-BI-D1870,S2843}

> <pdid>
PD003280

> <targets>
{RSK,"S6 Kinase"}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{25023738}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    7.7858   -9.1806    0.0000 N   0  0
    6.3110   -8.9071    0.0000 C   0  0
    5.3370  -10.0479    0.0000 O   0  0
    5.8106   -7.4921    0.0000 C   0  0
    6.7829   -6.3499    0.0000 C   0  0
    6.2798   -4.9368    0.0000 C   0  0
    4.8092   -4.6676    0.0000 C   0  0
    3.8322   -5.8080    0.0000 C   0  0
    4.3352   -7.2212    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    5.7171    0.9385    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 12 19  2  0
 19 20  1  0
 20 10  2  0
 19 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 29 30  2  0
 30 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28700

> <plate>
Kinase v5-2

> <well>
L14

> <supplier_cmpd_name>
D4476

> <ctcr_id>
2337

> <supplier_cmpd_id>
SY-D4476

> <smiles>
NC(=O)c1ccc(cc1)c2[nH]c(c3ccccn3)c(n2)c4ccc5OCCOc5c4

> <pd_targets>
{CSNK1A1,CSNK1D,MAPK14,CKA1,CSNK1E,PRKD1,CSNK1G1,CSNK1G2,TGFBR1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CK1 protein kinase group","CMGC protein kinase group","CAMK protein kinase group","TKL protein kinase group","CK1 protein kinase CK1 family","CMGC protein kinase MAPK 
family","CMGC protein kinase CK subfamily","CAMK protein kinase PKD family","TKL protein kinase STKR family","CMGC protein kinase p38 subfamily","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CK1: Casein kinase 1","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor ki
nases","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase D (PKD) family","TKL: Tyrosine kinase-like","p38 subfamily","Receptor serine/threonine kinase (R
STK) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{Disease,"Cell Cycle","Immune System",Metabolism,"Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Innate Immune System","Metabolism of lipids","Signaling by 
WNT in cancer","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Sphingolipid metabolism","Signaling by TGF-beta Receptor Complex in Cancer","Signaling by AMER1 mutants","G2/M Transition","Toll 
Like Receptor 5 (TLR5) Cascade","Sphingolipid de novo biosynthesis","Loss of Function of SMAD2/3 in Cancer","Truncations of AMER1 destabilize the destruction complex","Centrosome maturation","MyD88 ca
scade initiated on plasma membrane","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Loss of proteins required for interphase microtubule organization from the centrosome","MAP kinase activation","L
oss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{301836-43-1,301836431,D4476,"CK1 Inhibitor","casein kinase I inhibitor","D 4476",D-4476,"Casein Kinase I Inhibitor, D4476",CHEMBL410456,C23H18N4O3,K00227,MLS006010815,SCHEMBL373737,"InSolution&trade;
 Casein Kinase I Inhibitor, D4476",GTPL5940,SCHEMBL22857113,T2449,"EMD 218696",SY-D4476,2902,218696}

> <pdid>
PD012959

> <targets>
{"Casein Kinase 1",CK1}

> <classes>
{}

> <pubchem_cids>
{6419753}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  1  0            999 V2000
    3.9075   -3.7444    0.0000 C   0  0
    2.6060   -2.9986    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0  2  0  0  0
    3.8990   -0.7455    0.0000 N   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2004   -2.9933    0.0000 N   0  0
    6.4995   -3.7432    0.0000 C   0  0
    7.7985   -2.9932    0.0000 N   0  0
    7.7985   -1.4932    0.0000 C   0  0
    8.9127   -0.4902    0.0000 N   0  0
    8.3026    0.8801    0.0000 C   0  0
    6.8108    0.7233    0.0000 N   0  0
    6.4994   -0.7432    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 F   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
  1  2  1  0
  3  2  1  1
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  5  1  0
 13  9  2  0
  3 14  1  0
 14 15  2  3
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 20 22  2  0
 22 16  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 14  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28701

> <plate>
Kinase v5-2

> <well>
L16

> <supplier_cmpd_name>
CAL101

> <ctcr_id>
7581

> <supplier_cmpd_id>
SY-CAL101

> <smiles>
CC[C@H](Nc1ncnc2[nH]cnc12)C3=Nc4cccc(F)c4C(=O)N3c5ccccc5

> <pd_targets>
{PIK3C3,PIK3CD,PIK3CG,PIK3CB,PIK3CA,PIK3R1,PRKDC,PIK3R2}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,"Phosphatidylinositol 3-kinase family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-relat
ed kinases (PIKK) family","Other PIKK family kinases"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Metabolism,Disease,"Signaling by Receptor Tyrosine Kinases","Cytokine Signaling in Immune system","Metabolism of lipids","Diseases of signal transduction by grow
th factor receptors and second messengers","Innate Immune System","Signaling by Insulin receptor","Signaling by Interleukins","Phospholipid metabolism","Signaling by FGFR in disease","Cytosolic sensor
s of pathogen-associated DNA","Insulin receptor signalling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","PI Metabolism","Signaling by FGFR1 in disease","STING mediated induction of host
 immune responses","IRS-mediated signalling","Interleukin receptor SHC signaling","Synthesis of PIPs at the plasma membrane","FGFR1 mutant receptor activation","IRF3-mediated induction of type I IFN",
"PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"AL101 (IDELALISIB",GS-1101,GS1101,SCHEMBL356400,Idelalisib,870281-82-6,870281826,CAL-101,CAL101,Zydelig,"CAL 101",1146702-54-6,1146702546,UNII-YG57I8T5M0,UNIIYG57I8T5M0,"CAL-101 (Idelalisib, GS-1101
)","CAL101 (Idelalisib, GS1101)","Idelalisib (CAL-101)","Idelalisib (CAL101)","GS 1101",(S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinaz,(S)2(1(9Hpurin6ylamino)propyl)5fluoro3phenylquinaz,
T1894,759224,S2226,SY-CAL101}

> <pdid>
PD003400

> <targets>
{PI3K-delta,PI3K}

> <classes>
{}

> <pubchem_cids>
{11625818}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
   13.2231    5.8529    0.0000 Cl  0  0
   13.8427    4.4868    0.0000 C   0  0
   15.3355    4.3404    0.0000 C   0  0
   15.9551    2.9744    0.0000 C   0  0
   15.0819    1.7548    0.0000 C   0  0
   13.5890    1.9011    0.0000 C   0  0
   12.7129    0.6826    0.0000 N   0  0
   11.2194    0.8311    0.0000 C   0  0
   10.6021    2.1982    0.0000 O   0  0
   10.3432   -0.3874    0.0000 N   0  0
    8.8523   -0.2390    0.0000 C   0  0
    7.8525   -1.3573    0.0000 S   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 C   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 S   0  0
    0.0000   -1.5000    0.0000 C   0  0
    6.6317    0.7404    0.0000 C   0  0
    8.0978    1.0574    0.0000 N   0  0
   12.9695    3.2672    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 17  1  0
 25 21  2  0
 13 26  2  0
 26 27  1  0
 27 11  2  0
  6 28  2  0
 28  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28702

> <plate>
Kinase v5-2

> <well>
L18

> <supplier_cmpd_name>
SNS-314

> <ctcr_id>
5311

> <supplier_cmpd_id>
SY-SNS-314

> <smiles>
Clc1cccc(NC(=O)Nc2sc(CCNc3ncnc4ccsc34)cn2)c1

> <pd_targets>
{CSF1R,DDR2,NTRK1,NTRK2,AURKB,RAF1,FLT4,AURKA,AXL,KIT,CAMK2G,CDK8,PLK4,NTRK3,PDGFRB,SRPK1,MINK1,IRAK1,CAMK2B,HIPK4,SLK,PTK2,PRKCD,EPHA2,MELK,CAMK2D,CDK1,PRKD2,FRK,RPS6KB1,MKNK2,DYRK3,MAPK13,MET,ROCK2,
IRAK4,ROS1,CHEK2,CDK19,TYRO3,RET,CSNK1G2,BRSK1,MAP3K20,NEK4,KDR,CLK4,AURKC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","TKL protein kinase group","CAMK protein kinase group","CMGC protein kinase group","STE protein kinase group","AG
C protein kinase group","CK1 protein kinase group","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Trk family","Other protein kinase AUR family","T
KL protein kinase RAF family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Axl family","CAMK protein kinase CAMK2 family","CMGC protein kinase CDK family","Other protein kinase PLK 
family","CMGC protein kinase SRPK family","STE protein kinase STE20 family","TKL protein kinase IRAK family","CMGC protein kinase DYRK family","Tyrosine protein kinase Fak family","AGC protein kinase 
PKC family","Tyrosine protein kinase Eph family","CAMK protein kinase CAMK1 family","CAMK protein kinase PKD family","Tyrosine protein kinase Src family","AGC protein kinase RSK family","CAMK protein 
kinase MAPKAPK family","CMGC protein kinase MAPK family","Tyrosine protein kinase Met family","AGC protein kinase DMPK family","Tyrosine protein kinase Sev family","CAMK protein kinase RAD53 family","
Tyrosine protein kinase Ret family","CK1 protein kinase CK1 family","TKL protein kinase MLK family","Other protein kinase NEK family","CMGC protein kinase CLK family","CMGC protein kinase CDK8 subfami
ly","STE protein kinase MSN subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase SLK subfamily","AGC protein kinase PKC delta subfamily","CAMK protein kinase MELK subfamily","CMGC prote
in kinase CDC2 subfamily","AGC protein kinase p70 subfamily","CAMK protein kinase MNK subfamily","CMGC protein kinase Dyrk2 subfamily","CMGC protein kinase p38 subfamily","AGC protein kinase ROCK subf
amily","CAMK protein kinase BRSK subfamily","TKL protein kinase MLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs o
f yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CK1: Casein kinase 1","TK: Tyrosine kinase","Other protein kinases","TKL: Tyrosine kinase-like","CAMK2 fa
mily","Cyclin-dependent kinase (CDK) family","SRPK family","STE20 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Protein kinase C (PKC) family","CAMK-like (CAM
KL) family","Protein kinase D (PKD) family","RSK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Mitogen-activated protein kinases (MAP kinases)","DMPK family","Casein kinase 1 (CK1) family"
,"CLK family","Receptor tyrosine kinases (RTKs)","Aurora kinase (Aur) family","RAF family","CDK8 subfamily","Polo-like kinase (PLK) family","MSN subfamily","Interleukin-1 receptor-associated kinase (I
RAK) family","HIPK subfamily","SLK subfamily","Non-receptor tyrosine kinases (nRTKs)","Delta subfamily","MELK subfamily","CDK1 subfamily","p70 subfamily","MKN subfamily","Dyrk2 subfamily","p38 subfami
ly","Rho kinase","CHK1 subfamily","BRSK subfamily","Mixed Lineage Kinase (MLK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor fami
ly","Type XVI RTKs: DDR (collagen receptor) family","Type VII RTKs: Neurotrophin receptor/Trk family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XI RTKs: TAM (TYRO
3-","AXL- and MER-TK) receptor family","Fak family","Type XIII RTKs: Ephrin receptor family","Src family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XVII RTKs: ROS receptors",
"Type XIV RTKs: RET","MLK subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Extracellular matrix organization","Signal Transduction","Cell Cycle",Disease,"Neuronal System","Cellular responses to external stimuli","Immune System","Developmen
tal Biology",Metabolism,"RNA Polymerase II Transcription","Non-integrin membrane-ECM interactions","Signaling by Receptor Tyrosine Kinases",Mitotic,"MAPK family signaling cascades","Diseases of signal
 transduction by growth factor receptors and second messengers","Transmission across Chemical Synapses","Intracellular signaling by second messengers","Cellular responses to stress","Innate Immune Sys
tem","Infectious disease","Nervous system development","Metabolism of lipids","MTOR signalling","Generic Transcription Pathway","Signaling by NTRKs","M Phase","MAPK1/MAPK3 signaling","Signaling by VEG
F","Signaling by KIT in disease","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by NOTCH1 in Cancer","Mitotic G2-G2/M phases","PIP3 activates AKT signaling","Cellular Sen
escence","Toll-like Receptor Cascades","Leishmania infection","DAG and IP3 signaling","Axon guidance","Regulation of mitotic cell cycle","Sphingolipid metabolism","mTORC1-mediated signalling","Regulat
ion of lipid metabolism by PPARalpha","Transcriptional Regulation by VENTX","Signaling by NTRK1 (TRKA)","Mitotic Metaphase and Anaphase","RAF/MAP kinase cascade","VEGF ligand-receptor interactions","T
ranscriptional Regulation by TP53","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","Activation of NMDA receptors and postsynaptic events","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer"
,"G2/M Transition","Signaling by NTRK3 (TRKC)","Negative regulation of the PI3K/AKT network","Oxidative Stress Induced Senescence","Toll Like Receptor 5 (TLR5) Cascade","Parasite infection","CaM pathw
ay","EPH-Ephrin signaling","APC/C-mediated degradation of cell cycle proteins","Sphingolipid de novo biosynthesis","PTEN Regulation","Semaphorin interactions","Toll Like Receptor 2 (TLR2) Cascade","PP
ARA activates gene expression","RET signaling","Signalling to ERKs","Activation of TRKA receptors","Mitotic Anaphase","Negative regulation of MAPK pathway","VEGF binds to VEGFR leading to receptor dim
erization","Regulation of TP53 Activity","Dasatinib-resistant KIT mutants","Post NMDA receptor activation events","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Centrosome maturation","Act
ivated NTRK3 signals through PI3K",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","MyD88 cascade initiated on plasma membrane","Leishmania phagocytosis","Calmodulin induced events","EPHA-mediated gr
owth cone collapse","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of PTEN stability and activity","Sema4D in semaphorin signaling","Toll Like Receptor TLR6
:TLR2 Cascade","VEGFR2 mediated cell proliferation","Prolonged ERK activation events","NGF-independant TRKA activation","Separation of Sister Chromatids","Negative feedback regulation of MAPK pathway"
,"Regulation of TP53 Activity through Phosphorylation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Loss of proteins required for interphase microtubule organiza
tion from the centrosome","MAP kinase activation","FCGR3A-mediated phagocytosis","APC/C:Cdc20 mediated degradation of mitotic proteins","Signalling to RAS","Sema4D mediated inhibition of cell attachme
nt and migration","Sema4D induced cell migration and growth-cone collapse","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Regulation of TP53 Expression and Degradation","ARMS-mediated activa
tion","Ras activation upon Ca2+ influx through NMDA receptor","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK activation","APC:Cdc20 mediated degradation of cell cycle protein
s prior to satisfation of the cell cycle checkpoint","p38MAPK events","Regulation of TP53 Degradation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{AURKA,AURKB,AURKC}

> <broad_moa>
{"Aurora kinase inhibitor"}

> <synonyms>
{NS31,SNS-314,SNS314,1057249-41-8,1057249418,"SNS 314",UNII-802IFJ0Z8X,UNII802IFJ0Z8X,802IFJ0Z8X,"1057249-41-8 (free base)","1057249418 (free base)",C18H15ClN6OS2,SN-314,SN314,Kinome_3712,Kinome3712,K
inome-3712,"Kinome 3712",CHEMBL482767,GTPL9397,SCHEMBL3415843,BDBM26326,CHEBI:94720,AOB4643,DTXSID20147269,EX-A181,EXA181,SNS-314/SNS314,SNS314/SNS314,SYN1081,HMS3244O1,SY-SNS-314}

> <pdid>
PD005309

> <targets>
{"Aurora Kinases A",B,"& C"}

> <classes>
{}

> <pubchem_cids>
{24995524}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
   18.1924   -1.4596    0.0000 F   0  0
   16.8920   -0.7119    0.0000 C   0  0
   16.8892    0.7881    0.0000 C   0  0
   15.5888    1.5357    0.0000 C   0  0
   14.2910    0.7833    0.0000 C   0  0
   14.2939   -0.7167    0.0000 C   0  0
   15.5943   -1.4643    0.0000 C   0  0
   12.9888    1.5292    0.0000 N   0  0
   12.9836    3.0292    0.0000 C   0  0
   11.6820    3.7748    0.0000 C   0  0
   10.3856    3.0203    0.0000 C   0  0
   10.3907    1.5203    0.0000 C   0  0
    9.0920    0.7680    0.0000 C   0  0
    9.0945   -0.7320    0.0000 O   0  0
    7.7907    1.5158    0.0000 N   0  0
    6.4920    0.7636    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    5.2059   -2.9909    0.0000 F   0  0
    6.4972   -0.7364    0.0000 C   0  0
   11.6923    0.7748    0.0000 C   0  0
   11.6975   -0.7252    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 21  1  0
 29 25  2  0
 19 30  1  0
 30 31  1  0
 30 32  2  0
 32 16  1  0
 12 33  1  0
 33  8  1  0
 33 34  2  0
M  END
> <name>
UTKinase_V5

> <id>
28703

> <plate>
Kinase v5-2

> <well>
L20

> <supplier_cmpd_name>
BMS-2

> <ctcr_id>
462

> <supplier_cmpd_id>
SY-BMS-2

> <smiles>
Fc1ccc(cc1)N2C=CC=C(C(=O)Nc3ccc(Oc4ccnc5[nH]ccc45)c(F)c3)C2=O

> <pd_targets>
{FLT3,KIT,KDR,LCK,RIPK3,MET,RIPK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src family",
"Tyrosine protein kinase Met family","TKL protein kinase RIPK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Receptor interacting p
rotein kinase (RIPK) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Src family","Type X RTKs: HGF (hepatocyte
 growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System","Developmental Biology","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Infe
ctious disease","Innate Immune System","Nervous system development","Signaling by Insulin receptor","Signaling by KIT in disease","Signaling by VEGF","HIV Infection","Toll-like Receptor Cascades","Axo
n guidance","Insulin receptor signalling cascade","Drug resistance of KIT mutants","VEGFA-VEGFR2 Pathway","Host Interactions of HIV factors","Toll Like Receptor 4 (TLR4) Cascade","Semaphorin interacti
ons","IRS-mediated signalling","Dasatinib-resistant KIT mutants","VEGFR2 mediated cell proliferation","The role of Nef in HIV-1 replication and disease pathogenesis","MyD88-independent TLR4 cascade","
Sema4D in semaphorin signaling","PI3K Cascade","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","TRIF(TICAM1)-mediated TLR4 signaling","Sema4D mediated 
inhibition of cell attachment and migration","Nef Mediated CD4 Down-regulation","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MS,BMS-2,BMS2,888719-03-7,888719037,1FN,3ce3,"2-pyridone analogue, 2","2pyridone analogue, 2","JMC521251 Compound 1",CHEMBL509101,SCHEMBL4817260,BDBM24440,DTXSID50610618,SYN1022,C25H16F2N4O3,BCPP0003
29,MFCD16619360,ZINC20148998,BCP9000423,DB06896,NCGC00345824-01,NCGC0034582401,NCGC00345824-02,NCGC0034582402,FT-0729495,FT0729495,7,SY-BMS-2}

> <pdid>
PD005804

> <targets>
{Met/Flt-3/VEGFR2,MET}

> <classes>
{}

> <pubchem_cids>
{21081761}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
   -3.9323   -9.7235    0.0000 C   0  0
   -2.6374  -10.4807    0.0000 O   0  0
   -1.3331   -9.7383    0.0000 C   0  0
   -1.3269   -8.2383    0.0000 C   0  0
   -0.0248   -7.4935    0.0000 C   0  0
   -0.0156   -5.9927    0.0000 N   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    5.1932   -3.0130    0.0000 F   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1781   -0.0305    0.0000 C   0  0
   -3.8619    2.2496    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    1.2935   -3.7495    0.0000 N   0  0
    1.2712   -8.2490    0.0000 C   0  0
    1.2650   -9.7490    0.0000 C   0  0
    2.5632  -10.5020    0.0000 O   0  0
    3.8643   -9.7555    0.0000 C   0  0
   -0.0371  -10.4936    0.0000 C   0  0
   -0.0464  -11.9944    0.0000 O   0  0
   -1.3495  -12.7372    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  1  0
 19 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 17  1  0
 25 26  2  0
 26 14  1  0
 12 27  2  0
 27  7  1  0
  5 28  2  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 29 32  2  0
 32  3  1  0
 32 33  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28704

> <plate>
Kinase v5-2

> <well>
L22

> <supplier_cmpd_name>
R406

> <ctcr_id>
4240

> <supplier_cmpd_id>
SY-R406

> <smiles>
COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC

> <pd_targets>
{MARK3,PAK1,PDPK1,MAPK8,RAF1,ROS1,MAP2K4,TEC,TTK,PIP4K2B,CAMK1,ACVR1B,EPHA2,EPHA7,DYRK4,SYK,ROCK2,ABL1,EGFR,MUSK,PRKCD,MAPK12,PRKAA1,DDR2,JAK3,KIT,HIPK2,MAP2K2,MET,MYLK4,MAP4K1,CDK2,CSNK2A1,GSK3B,TLK1
,PIP5K1C,INSRR,TNIK,TAOK3,MKNK2,RET,PKNB,MAPK9,NEK11,AURKB,AAK1,FLT3,TYK2,JAK1,SLK,DAPK2,CDKL2,MAP4K3,EPHB1,EPHB6,MAPK14,PIK3CD,SRC,TIE1,DCLK3,STK35,RPS6KA5,DAPK1,PLK1,ROCK1,PTK6,MAP3K2,LIMK1,MAP3K11,
NEK2,STK16,MAPK13,RPS6KA1,DYRK2,PLK3,ALK,LRRK2,WEE2,PRKCG,MAPK1,MAPK3,MAP3K3,PRKACA,MAP2K1,PTK2B,EPHA5,ZAP70,AURKC,NTRK3,TNK2,PIP5K1A,DDR1,COQ8A,CAMK1G,COQ8B,MAP3K19,MARK1,LYN,MAP3K10,GRK1,NEK4,RPS6KB
1,TGFBR2,STK17B,BRAF,EIF2AK2,ULK1,ANKK1,SBK3,BTK,STK32A,ULK3,CAMK1D,RIOK1,NEK9,IGF1R,PIM3,PAK4,ERBB4,ACVR1,BMX,KDR,NEK1,TNNI3K,GSK3A,RIPK4,FGFR1,TSSK1B,MAP3K7,HIPK1,FYN,EPHA6,STK38,SRPK3,NEK6,IRAK4,PR
KG2,PRKAA2,NEK7,MAP3K9,PI4KB,MAP2K3,MAP2K6,WEE1,PTK2,GRK4,NEK5,CLK1,TEK,SBK1,CSNK2A2,IRAK1,STK33,RIOK2,TAOK1,MARK4,TLK2,NUAK2,FGFR3,EIF2AK4,CHEK1,CHUK,DAPK3,FLT1,FRK,PLK4,LATS2,SIK2,EPHA8,FGFR2,PIP4K2
C,MAPK15,CIT,EPHB2,TESK1,RIPK2,OXSR1,FER,YES1,DYRK1A,STK17A,JAK2,ABL2,CSF1R,LCK,ITK,PRKD3,MAP3K4,PDGFRA,LIMK2,HIPK3,NTRK2,NEK3,SRPK1,AURKA,EPHB4,CAMK2A,CAMK2G,LTK,CDK1,STK11,PAK5,PAK3,MAPK10,SIK1,HIPK
4,CAMK2D,HCK,CDK7,ERN1,BMP2K,PAK6,MKNK1,BLK,STK36,CLK4,EPHA1,TBK1,IKBKE,TAOK2,STK3,RIOK3,CLK3,EPHA3,PAK2,PDGFRB,STK10,PKN2,MYLK,MERTK,RPS6KA4,IKBKB,NUAK1,MARK2,GRK7,FLT4,INSR,MST1R,ULK2,RPS6KA3,GAK,PR
KACB,CLK2,CDKL1,NIM1K,MAP2K5,CDK17,AXL,FES,CDK5,PLK2,ERBB2,NTRK1,BMPR1B,IRAK3,TNK1,CSK,MAP4K2,EPHA4,PKN1,FGFR4,TYRO3,STK25,TXK,CDC7,PHKG2,PRKD2,FGR,SRMS,TGFBR1}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Kinase,Transferase,"Protein Kinase","CAMK protein kinase group","STE protein kinase group","AGC protein kinase group","CMGC protein kinase group","TKL protein kinase gro
up","TK protein kinase group","Other protein kinase group","Atypical protein kinase group","CAMK protein kinase CAMK1 family","STE protein kinase STE20 family","AGC protein kinase PDK1 subfamily","CMG
C protein kinase MAPK family","TKL protein kinase RAF family","Tyrosine protein kinase Sev family","STE protein kinase STE7 family","Tyrosine protein kinase Tec family","Other protein kinase TTK famil
y","TKL protein kinase STKR family","Tyrosine protein kinase Eph family","CMGC protein kinase DYRK family","Tyrosine protein kinase Syk family","AGC protein kinase DMPK family","Tyrosine protein kinas
e Abl family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Musk family","AGC protein kinase PKC family","Tyrosine protein kinase DDR family","Tyrosine protein kinase JakA family","Ty
rosine protein kinase PDGFR family","Tyrosine protein kinase Met family","CAMK protein kinase MLCK family","CMGC protein kinase CDK family","Other protein kinase CK2 family","CMGC protein kinase GSK f
amily","Other protein kinase TLK family","Tyrosine protein kinase InsR family","CAMK protein kinase MAPKAPK family","Tyrosine protein kinase Ret family","Other protein kinase NEK family","Other protei
n kinase AUR family","Other protein kinase NAK family","CAMK protein kinase DAPK family","CMGC protein kinase CDKL family","Tyrosine protein kinase Src family","Tyrosine protein kinase Tie family","CA
MK protein kinase DCAMK1 family","Other protein kinase NKF4 family","AGC protein kinase RSK family","Other protein kinase PLK family","STE protein kinase STE11 family","TKL protein kinase LISK family"
,"TKL protein kinase MLK family","TKL protein kinase LRRK family","Other protein kinase WEE family","AGC protein kinase PKA family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Trk fa
mily","Tyrosine protein kinase Ack family","Atypical protein kinase ABC1 family","AGC protein kinase GRK family","Other protein kinase PEK family","Other protein kinase ULK family","TKL protein kinase
 RIPK family","Other protein kinase NKF1 family","AGC protein kinase YANK family","Atypical protein kinase RIO family","CAMK protein kinase PIM family","Tyrosine protein kinase VEGFR family","Tyrosine
 protein kinase FGFR family","CAMK protein kinase TSSK family","AGC protein kinase NDR family","CMGC protein kinase SRPK family","TKL protein kinase IRAK family","AGC protein kinase PKG family","CMGC 
protein kinase CLK family","CAMK protein kinase unique family","Other protein kinase IKK family","Tyrosine protein kinase Fer family","CAMK protein kinase PKD family","CAMK protein kinase CAMK2 family
","Tyrosine protein kinase Alk family","AGC protein kinase PKN family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Csk family","Other protein kinase CDC7 family","CAMK protein kinase
 PHk family","CAMK protein kinase MARK subfamily","STE protein kinase PAKA subfamily","CMGC protein kinase JNK subfamily","TKL protein kinase STKR Type 1 subfamily","AGC protein kinase ROCK subfamily"
,"AGC protein kinase PKC delta subfamily","CMGC protein kinase p38 subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase KHS subfamily","CMGC protein
 kinase CDC2 subfamily","STE protein kinase MSN subfamily","STE protein kinase TAO subfamily","CAMK protein kinase MNK subfamily","Other protein kinase Nek11","STE protein kinase SLK subfamily","AGC p
rotein kinase MSK subfamily","STE protein kinase MEKK2","TKL protein kinase LIMK subfamily","TKL protein kinase MLK subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase Dyrk2 subfamily",
"Other protein kinase WEE1","AGC protein kinase PKC alpha subfamily","CMGC protein kinase ERK1","Atypical protein kinase ABC1-A subfamily","AGC protein kinase GRK subfamily","AGC protein kinase p70 su
bfamily","TKL protein kinase STKR Type 2 subfamily","Other protein kinase PKR","Atypical protein kinase RIO1 subfamily","STE protein kinase PAKB subfamily","TKL protein kinase STKR1","TKL protein kina
se HH498 subfamily","TKL protein kinase TAK1 subfamily","Tyrosine protein kinase SrcA","Atypical protein kinase RIO2 subfamily","CAMK protein kinase NuaK subfamily","Other protein kinase GCN2 subfamil
y","CAMK protein kinase CHK1 subfamily","CAMK protein kinase QIK subfamily","AGC protein kinase CRIK subfamily","TKL protein kinase TESK subfamily","STE protein kinase FRAY subfamily","CMGC protein ki
nase Dyrk1 subfamily","Other protein kinase Nek1","CAMK protein kinase LKB subfamily","CMGC protein kinase CDK7 subfamily","STE protein kinase MST subfamily","Atypical protein kinase RIO3 subfamily","
CAMK protein kinase NIM1 subfamily","CMGC protein kinase PCTAIRE","CMGC protein kinase CDK5 subfamily","Other protein kinase PLK2","STE protein kinase YSK subfamily","Tyrosine protein kinase Srm"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CAMK: Calcium/calmodulin-dependent protein kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containi
ng PKA",PKG,"PKC families","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","Lipid modifying kinases",Atypical,"CAMK-like (CAMKL) family","STE20 family","PDK1 family","Mitogen-activa
ted protein kinases (MAP kinases)","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","STE7 family","Other protein kinases","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","C
AMK1 family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","DMPK family","Protein kinase C (PKC) family","Myosin Light Chain Kinase (MLCK) family","Cyclin-dependent ki
nase (CDK) family","Glycogen synthase kinase (GSK) family","Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","MAPK-Activated Protein Kinase (MAPKAPK) family","Death-associated 
kinase (DAPK) family","Cyclin-dependent kinase-like (CDKL) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","DCAMKL family","RSK family","STE11 family","Protein kinase A (PKA) family","
ABC1 family","G protein-coupled receptor kinases (GRKs)","YANK family","RIO family","PIM family","Testis specific kinase (TSSK) family","NDR family","SRPK family","Protein kinase G (PKG) family","1-ph
osphatidylinositol 4-kinase family","CLK family","CAMK-unique family","Protein kinase D (PKD) family","CAMK2 family","Protein kinase N (PKN) family","Phosphorylase kinase (PHK) family","MARK subfamily
","PAKA subfamily","JNK subfamily","RAF family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","TTK family","Receptor serine/threonine kinase (RSTK) family","Dyrk1 subfamil
y","Rho kinase","Delta subfamily","p38 subfamily","AMPK subfamily","HIPK subfamily","KHS subfamily","CDK1 subfamily","Casein kinase 2 (CK2) family","GSK subfamily","Tousled-like kinase (TLK) family","
MSN subfamily","TAO subfamily","MKN subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","Aurora kinase (Aur) family","NAK family","SLK subfamily","NKF4 family","MSK subfamily","Po
lo-like kinase (PLK) family","LIM domain kinase (LISK) family","Mixed Lineage Kinase (MLK) family","RSK subfamily","Dyrk2 subfamily","Leucine-rich repeat kinase (LRRK) family","WEE family","Alpha subf
amily","ABC1-B subfamily","STE20 subfamily","Opsin/rhodopsin kinases","p70 subfamily","PEK family","Unc-51-like kinase (ULK) family","Receptor interacting protein kinase (RIPK) family","NKF1 family","
RIO1 subfamily","PAKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","GRK4 subfamily","RIO2 subfamily","NuaK subfamily","CHK1 subfamily","IKK family","QIK subfamily","Erk7 subfami
ly","Other DMPK family kinases","FRAY subfamily","LKB subfamily","CDK7 subfamily","IRE family","Numb-associated kinase (NAK) family","MST subfamily","RIO3 subfamily","NIM1 subfamily","TAIRE subfamily"
,"CDK5 subfamily","YSK subfamily","CDC7 family","Type XVII RTKs: ROS receptors","Tec family","Type I receptor serine/threonine kinases","Type XIII RTKs: Ephrin receptor family","Syk family","Abl famil
y","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IX RTKs: MuSK","Type XVI RTKs: DDR (collagen receptor) family","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3
 receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type II RTKs: Insulin receptor family","Type XIV RTKs: RET","Src family","Type XII RTKs: TIE family of angiopoietin rec
eptors","LIMK subfamily","MLK subfamily","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Fak family","Type VII RTKs: Neurotrophin receptor/Trk family","Ack family","Type II receptor 
serine/threonine kinases","Other PEK family kinases","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","HH498 subfamily","Type V RTKs: FGF (fibroblast growth factor) receptor f
amily","TAK1 subfamily","GCN2 subfamily","TESK subfamily","Fer family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Csk family"}

> <pathway_reactome>
{Disease,"Developmental Biology","Gene expression (Transcription)","Immune System","Signal Transduction","Neuronal System","Extracellular matrix organization","Cellular responses to external stimuli",
"Cell Cycle","Vesicle-mediated transport","Programmed Cell Death",Metabolism,Autophagy,"Metabolism of RNA","Organelle biogenesis and maintenance","DNA Repair","Cell-Cell communication","Circadian Cloc
k","Metabolism of proteins",Hemostasis,"Diseases of signal transduction by growth factor receptors and second messengers","Nervous system development","RNA Polymerase II Transcription","Innate Immune 
System","MAPK family signaling cascades","Cytokine Signaling in Immune system","Transmission across Chemical Synapses","Signaling by NODAL","Infectious disease","Signaling by GPCR","ECM proteoglycans"
,"Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases","Non-integrin membrane-ECM interactions","Cellular responses to stress",Mitotic,"Membrane Trafficking",Apoptosi
s,"Signaling by Non-Receptor Tyrosine Kinases","Adaptive Immune System","Metabolism of lipids","MTOR signalling",Macroautophagy,"Signaling by Hedgehog","rRNA processing","Cell Cycle Checkpoints","Cili
um Assembly","DNA Double-Strand Break Repair","Signaling by Hippo","Signaling by Rho GTPases","Cell junction organization","Unfolded Protein Response (UPR)","Cell surface interactions at the vascular 
wall","Signaling by TGFB family members","Metabolism of carbohydrates","Oncogenic MAPK signaling","Axon guidance","Generic Transcription Pathway","Toll-like Receptor Cascades","MAPK1/MAPK3 signaling",
"Signaling by Interleukins","Neurotransmitter receptors and postsynaptic signal transmission","Regulation of signaling by NODAL","Leishmania infection","GPCR downstream signalling","DAG and IP3 signal
ing","Signaling by NTRKs","Signaling by KIT in disease","SARS-CoV Infections","Cellular Senescence","M Phase","Clathrin-mediated endocytosis","Signaling by Insulin receptor","Interferon Signaling","Ca
spase activation via extrinsic apoptotic signalling pathway","Mitotic G2-G2/M phases","Mitotic G1 phase and G1/S transition","Regulation of mitotic cell cycle","Signaling by PTK6","TCR signaling","Pho
spholipid metabolism","mTORC1-mediated signalling","Signaling by TGF-beta Receptor Complex in Cancer","Influenza Infection","Selective autophagy","Hedgehog 'on' state","rRNA processing in the nucleus 
and cytosol","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Signaling by VEGF","Signaling by FGFR in disease","HIV Infection","G2/M Checkpoints","Anchoring of the basal body to t
he plasma membrane","Response of EIF2AK4 (GCN2) to amino acid deficiency","Homology Directed Repair","PIP3 activates AKT signaling","RHO GTPase Effectors","Cell-extracellular matrix interactions","Sig
naling by SCF-KIT","Sphingolipid metabolism","Signaling by PDGFR in disease","IRE1alpha activates chaperones","Signaling by FGFR","Neutrophil degranulation","Signaling by MST1","trans-Golgi Network Ve
sicle Budding","Signaling by BMP","Fc epsilon receptor (FCERI) signaling","Glycogen metabolism","Signaling by RAS mutants","EPH-Ephrin signaling","Transcriptional Regulation by TP53","Toll Like Recept
or 5 (TLR5) Cascade","RAF/MAP kinase cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Activation of NMDA receptors and postsynaptic events","Leishmania parasite growth and survival","Semap
horin interactions","Parasite infection","G alpha (q) signalling events","CaM pathway","Signaling by NTRK1 (TRKA)","Interleukin-2 family signaling","Drug resistance of KIT mutants","SARS-CoV-1 Infecti
on","Oxidative Stress Induced Senescence","RET signaling","Mitotic Metaphase and Anaphase","Cargo recognition for clathrin-mediated endocytosis","Insulin receptor signalling cascade","Interferon alpha
/beta signaling","Antiviral mechanism by IFN-stimulated genes","Caspase activation via Dependence Receptors in the absence of ligand","G2/M Transition","G1 Phase","APC/C-mediated degradation of cell c
ycle proteins","PTK6 promotes HIF1A stabilization","Glutamate binding","activation of AMPA receptors and synaptic plasticity","Interleukin-1 family signaling","Generation of second messenger molecules
","Signaling by NTRK3 (TRKC)","PI Metabolism","G alpha (i) signalling events","Loss of Function of SMAD2/3 in Cancer","NS1 Mediated Effects on Host Pathways",Mitophagy,"Major pathway of rRNA processin
g in the nucleolus and cytosol","Mitotic Prophase","IGF1R signaling cascade","Signaling by ROBO receptors","VEGFA-VEGFR2 Pathway","Signaling by FGFR1 in disease","Toll Like Receptor 4 (TLR4) Cascade",
"Host Interactions of HIV factors","Toll Like Receptor 2 (TLR2) Cascade","G2/M DNA damage checkpoint","Signaling by FGFR3 in disease","HDR through Homologous Recombination (HRR) or Single Strand Annea
ling (SSA)","VEGF ligand-receptor interactions","PTEN Regulation","Signaling by FGFR2 in disease","RHO GTPases activate CIT","Regulation of cytoskeletal remodeling and cell spreading by IPP complex co
mponents","G0 and Early G1","Transcriptional Regulation by VENTX","Sphingolipid de novo biosynthesis","Drug resistance of PDGFR mutants","HIV Life Cycle","Signaling by FGFR4","Transcriptional regulati
on by RUNX1","Negative regulation of the PI3K/AKT network","RHO GTPases activate PKNs","RHO GTPases activate PAKs","L1CAM interactions","Golgi Associated Vesicle Biogenesis","FCERI mediated Ca+2 mobil
ization","G1/S Transition","Glycogen breakdown (glycogenolysis)","PTK6 Down-Regulation","Signaling downstream of RAS mutants","EPHB-mediated forward signaling","Regulation of TP53 Activity","MyD88 cas
cade initiated on plasma membrane","Negative regulation of MAPK pathway","Post NMDA receptor activation events","EPHA-mediated growth cone collapse","Anti-inflammatory response favouring Leishmania pa
rasite infection","Sema4D in semaphorin signaling","Leishmania phagocytosis","Gastrin-CREB signalling pathway via PKC and MAPK","Calmodulin induced events","Signalling to ERKs","Interleukin-15 signali
ng","Dasatinib-resistant KIT mutants","SARS-CoV-1 Genome Replication and Transcription","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Mitotic Anaphase","IRS-mediated signalling"
,"Regulation of IFNA signaling","ISG15 antiviral mechanism","Interleukin receptor SHC signaling","Centrosome maturation","Cyclin D associated events in G1","Activation of APC/C and APC/C:Cdc20 mediate
d degradation of mitotic proteins","Trafficking of AMPA receptors","Interleukin-1 signaling","Interleukin-2 signaling","Activated NTRK3 signals through PI3K","Synthesis of PIPs at the plasma membrane"
,"Visual phototransduction","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Inhibition of PKR","Receptor Mediated Mitophagy","Nuclear Envelope Breakdown","IRS-related events triggered by IGF1R","Ac
tivation of RAC1","VEGFR2 mediated cell proliferation","FGFR1 mutant receptor activation","MyD88-independent TLR4 cascade","The role of Nef in HIV-1 replication and disease pathogenesis","Toll Like Re
ceptor TLR6:TLR2 Cascade","RAS processing","Synthesis of PIPs at the Golgi membrane","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Signaling by FGFR3 point mutants in cancer","HDR 
through Homologous Recombination (HRR)","VEGF binds to VEGFR leading to receptor dimerization","Regulation of PTEN stability and activity","FGFR2 mutant receptor activation","Role of ABL in ROBO-SLIT 
signaling","Imatinib-resistant PDGFR mutants","Activation of TRKA receptors","Ephrin signaling","Late Phase of HIV Life Cycle","Negative regulation of FGFR4 signaling","RUNX1 regulates transcription o
f genes involved in BCR signaling",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Recycling pathway of L1","Signalling to ERK5","CRMPs in Sema3A signaling","Activated PKN1 stimulates transcription 
of AR (androgen receptor) regulated genes KLK2 and KLK3","Downstream signaling of activated FGFR4","Activation of the pre-replicative complex","Regulation of TP53 Expression and Degradation","MAP kina
se activation","Negative feedback regulation of MAPK pathway","Regulation of TP53 Activity through Acetylation","Activation of RAC1 downstream of NMDARs","FCGR3A-mediated IL10 synthesis","Sema4D induc
ed cell migration and growth-cone collapse","FCGR3A-mediated phagocytosis","EGFR Transactivation by Gastrin","Signalling to RAS","Regulation of TP53 Activity through Phosphorylation","Prolonged ERK ac
tivation events","Sema4D mediated inhibition of cell attachment and migration","Replication of the SARS-CoV-1 genome","Separation of Sister Chromatids","PI3K Cascade","Loss of proteins required for in
terphase microtubule organization from the centrosome","APC/C:Cdc20 mediated degradation of mitotic proteins","Trafficking of GluR2-containing AMPA receptors","The phototransduction cascade","Activati
on of NIMA Kinases NEK9",NEK6,NEK7,"Long-term potentiation","Signaling by activated point mutants of FGFR1","TRIF(TICAM1)-mediated TLR4 signaling","Nef and signal transduction","MyD88:MAL(TIRAP) casca
de initiated on plasma membrane","FGFR3 mutant receptor activation","Homologous DNA Pairing and Strand Exchange","Activated point mutants of FGFR2","Nef-mediates down modulation of cell surface recept
ors by recruiting them to clathrin adapters","NGF-independant TRKA activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Transcription of the HIV genome","Spr
y regulation of FGF signaling","PKA-mediated phosphorylation of CREB","CD163 mediating an anti-inflammatory response","FRS-mediated FGFR4 signaling","Regulation of TP53 Degradation","MAPK targets/ Nuc
lear events mediated by MAP kinases","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","PI5P Regulates TP53 Acetylation","p38MAPK events","Frs2-mediated activation
","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",Inactivation,"recovery and regulation of the phototra
nsduction cascade","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","activated TAK1 mediates p38 MAPK activation","Signaling by activated point mutants of FGFR
3","Presynaptic phase of homologous DNA pairing and strand exchange","IKK complex recruitment mediated by RIP1","Nef Mediated CD4 Down-regulation","Ras activation upon Ca2+ influx through NMDA recepto
r","HIV Transcription Elongation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","PKA activation","Activation of the AP-1 family of transcription factors","CREB phosphorylation","APC-Cdc20 med
iated degradation of Nek2A","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{RET,SYK}

> <broad_moa>
{"SYK inhibitor"}

> <synonyms>
{"Tamatinib free base",841290-80-0,841290800,"841290 80 0",R-406,R406,"R 406","R406 (free base)",tamatinib,"R406 free base","R406(free base)",UNII-RC3A285J2G,UNIIRC3A285J2G,"UNII RC3A285J2G",CHEMBL475
251,RC3A285J2G,"841290-80-0 (free base)","841290800 (free base)","841290 80 0 (free base)",C22H23FN6O5,BDBM50249542,3fqs,3piy,Kinome_1211,Kinome1211,Kinome-1211,"Kinome 1211",PubChem22483,QCR-9,QCR9,"
QCR 9",c,T2467,SY-R406,S1533}

> <pdid>
PD003501

> <targets>
{Syk}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{11213558}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 F   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 F   0  0
    3.8975   -2.2510    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.3786   -3.8595    0.0000 S   0  0
   -1.8371   -5.2877    0.0000 C   0  0
   -0.9513   -6.4982    0.0000 O   0  0
   -3.3371   -5.2929    0.0000 N   0  0
   -3.8056   -3.8680    0.0000 C   0  0
   -5.2311   -3.4009    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
  9 18  2  0
 18  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28705

> <plate>
Kinase v5-2

> <well>
N04

> <supplier_cmpd_name>
SMI-4a

> <ctcr_id>
7363

> <supplier_cmpd_id>
SY-SMI-4a

> <smiles>
FC(F)(F)c1cccc(/C=C/2SC(=O)NC2=O)c1

> <pd_targets>
{PIM1,PIM2,TTR,CISD1}

> <pathway_gtopdb>
{Enzyme,"Secreted protein","Unclassified protein",Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase PIM family"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Kinases (EC 2.7.x.x)",Transthyretin,"CAMK: Calcium/calmodulin-dependent protein kinases","PIM family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by GPCR","FLT3 signaling in disease","GPCR downstream signalling","Signalin
g by FLT3 ITD and TKD mutants","G alpha (i) signalling events","STAT5 activation downstream of FLT3 ITD mutants","Visual phototransduction","The canonical retinoid cycle in rods (twilight vision)"}

> <broad_targets>
{PIM1}

> <broad_moa>
{"Pim kinase inhibitor"}

> <synonyms>
{"CS PIM1 4",438190-29-5,438190295,SMI-4a,SMI4a,"SMI 4a","TCS PIM-1 4a","TCS PIM1 4a",(Z)-SMI-4a,(Z)SMI4a,"(Z)-5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione","(Z)5(3(trifluoromethyl)benzyli
dene)thiazolidine2,4dione","(5Z)-5-(3-(trifluoromethyl)benzylidene)-1,3-thiazolidine-2,4-dione","(5Z)5(3(trifluoromethyl)benzylidene)1,3thiazolidine2,4dione",CHEMBL183906,(5Z)-5-((3-(TRIFLUOROMETHYL)P
HENYL)METHY,(5Z)5((3(TRIFLUOROMETHYL)PHENYL)METHY,SY-SMI-4a,"EMD 526523",nan,S8005,526523}

> <pdid>
PD010270

> <targets>
{PIM,Pim}

> <classes>
{}

> <pubchem_cids>
{1361334}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    6.0921   -5.7983    0.0000 N   0  0
    6.7064   -4.4299    0.0000 C   0  0
    7.3211   -3.0607    0.0000 C   0  0
    6.4434   -1.8433    0.0000 C   0  0
    7.0565   -0.4733    0.0000 C   0  0
    6.3038    0.8093    0.0000 C   0  0
    7.3128    1.9192    0.0000 C   0  0
    8.6802    1.3025    0.0000 C   0  0
    8.5162   -0.1885    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  3  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  5  1  0
  4 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 10  1  0
 12 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 15  1  0
 23 19  2  0
M  END
> <name>
UTKinase_V5

> <id>
28706

> <plate>
Kinase v5-2

> <well>
N06

> <supplier_cmpd_name>
INCB018424  (Ruxolitinib)

> <ctcr_id>
1339

> <supplier_cmpd_id>
SY-INCB018424

> <smiles>
N#CCC(C1CCCC1)n2cc(cn2)c3ncnc4[nH]ccc34

> <pd_targets>
{IKBKE,ABL1,JAK2,RET,MAP4K4,LCK,GRK5,GSK3A,AURKB,JAK3,DYRK1B,FGFR1,CSNK1A1,CDK8,NTRK2,ALK,PRKAA1,DYRK1A,TAOK1,DAPK3,CLK2,LTK,PTK2,ROCK1,FYN,LRRK2,TNK2,PAK4,GSK3B,PRKACA,CAMK1D,CAMK2A,NTRK3,AURKA,PRKD3
,CLK4,MAP3K2,IKBKB,GRK7,CAMK2G,KIT,DCLK2,RPS6KA6,MKNK2,JAK1,PRKCE,VRK2,PLK4,PAK5,MAP3K19,TYK2,BMPR1B,CDK7,NEK7,MAP2K4,TTK,BRAF,ROCK2,BMPR2,STK26,RIPK4,RIOK1,BMP2K,MAP4K2,HDAC6,PI4KB,MAP2K1,CASK,CAMK2D
,SBK1,DCLK3,ANKK1,NTRK1,ULK3,CSNK2A1,PKNB,GAK,SRPK3,ULK2,MAST1,TAOK2,MARK2,TAOK3,RIOK3,PLK3,EPHB6,DCLK1,OXSR1,MAPK8,GRK1,CAMK1,STK17B,DMPK,CAMK2B,ERN1,CSNK2A2,NEK3,HIPK1,RIOK2,PAK6,AURKC,MAP3K15,RPS6K
A2,IRAK1,MAP2K3,ULK1,PLK1,EPHA3,NR1H2,HIPK3,MAP3K1,PHKG1,STK25,DAPK2,AAK1,CAMK1G,HIPK2,NUAK2,SIK3,PHKG2,MAP3K3,GRK4,PRKG2,PLK2,STK39,TBK1,MELK,MAP2K2,RPS6KA1,SRPK1,DYRK2,STK17A,RPS6KA5,DAPK1,STK16,RPS
6KA4,MYLK,MAP3K7,SBK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","TK protein kinase group","STE protein kinase group","AGC protein kinase group","CMGC protein kinase group","CK1 protein kinase group","TKL
 protein kinase group","CAMK protein kinase group","Tyrosine protein kinase Abl family","Tyrosine protein kinase JakA family","Tyrosine protein kinase Ret family","STE protein kinase STE20 family","Ty
rosine protein kinase Src family","AGC protein kinase GRK family","CMGC protein kinase GSK family","Other protein kinase AUR family","CMGC protein kinase DYRK family","Tyrosine protein kinase FGFR fam
ily","CK1 protein kinase CK1 family","CMGC protein kinase CDK family","Tyrosine protein kinase Trk family","TKL protein kinase STKR family","CAMK protein kinase CAMK1 family","CAMK protein kinase DAPK
 family","CMGC protein kinase CLK family","Tyrosine protein kinase Alk family","Tyrosine protein kinase Fak family","AGC protein kinase DMPK family","TKL protein kinase LRRK family","Tyrosine protein 
kinase Ack family","AGC protein kinase PKA family","CAMK protein kinase CAMK2 family","CAMK protein kinase PKD family","STE protein kinase MSN subfamily","AGC protein kinase GRK subfamily","CMGC prote
in kinase Dyrk1 subfamily","CMGC protein kinase CDK8 subfamily","TKL protein kinase STKR Type 1 subfamily","CAMK protein kinase AMPK subfamily","STE protein kinase TAO subfamily","AGC protein kinase R
OCK subfamily","Tyrosine protein kinase SrcA","STE protein kinase PAKB subfamily","Epigenetic regulator","Unclassified protein","Transcription factor",Eraser,Transferase,"Nuclear receptor","Histone de
acetylase","Nuclear hormone receptor subfamily 1","Atypical protein kinase group","HDAC class IIb","Nuclear hormone receptor subfamily 1 group H","STE protein kinase STE11 family","Other protein kinas
e IKK family","Tyrosine protein kinase PDGFR family","CAMK protein kinase DCAMK1 family","AGC protein kinase RSK family","CAMK protein kinase MAPKAPK family","AGC protein kinase PKC family","Other pro
tein kinase PLK family","Other protein kinase NEK family","STE protein kinase STE7 family","Other protein kinase TTK family","TKL protein kinase RAF family","TKL protein kinase RIPK family","Atypical 
protein kinase RIO family","Other protein kinase NAK family","Other protein kinase NKF1 family","Other protein kinase ULK family","Other protein kinase CK2 family","CMGC protein kinase SRPK family","A
GC protein kinase MAST family","CMGC protein kinase MAPK family","TKL protein kinase IRAK family","Tyrosine protein kinase Eph family","Nuclear hormone receptor subfamily 1 group H member 3","CAMK pro
tein kinase PHk family","AGC protein kinase PKG family","CAMK protein kinase MLCK family","TKL protein kinase MLK family","STE protein kinase MEKK2","AGC protein kinase RSK subfamily","CAMK protein ki
nase MNK subfamily","AGC protein kinase PKC eta subfamily","CMGC protein kinase CDK7 subfamily","TKL protein kinase STKR Type 2 subfamily","STE protein kinase YSK subfamily","Atypical protein kinase R
IO1 subfamily","STE protein kinase KHS subfamily","CAMK protein kinase MARK subfamily","Atypical protein kinase RIO3 subfamily","STE protein kinase FRAY subfamily","CMGC protein kinase JNK subfamily",
"AGC protein kinase GEK subfamily","Other protein kinase Nek1","CMGC protein kinase HIPK subfamily","Atypical protein kinase RIO2 subfamily","STE protein kinase ASK","CAMK protein kinase NuaK subfamil
y","CAMK protein kinase QIK subfamily","Other protein kinase PLK2","CAMK protein kinase MELK subfamily","CMGC protein kinase Dyrk2 subfamily","AGC protein kinase MSK subfamily","TKL protein kinase TAK
1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CMGC: 
Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","TK: Tyrosine kinase","STE20 family","G protein-coupled rec
eptor kinases (GRKs)","Glycogen synthase kinase (GSK) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Casein kinase 1 (CK1) family","Cyclin-dependent kinase (CD
K) family","CAMK-like (CAMKL) family","Death-associated kinase (DAPK) family","CLK family","DMPK family","TKL: Tyrosine kinase-like","Protein kinase A (PKA) family","CAMK1 family","CAMK2 family","Prot
ein kinase D (PKD) family","IKK family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","MSN subfamily","GRK4 subfamily","GSK subfamily","Aurora kinase (Aur) family","Dyrk1 
subfamily","CDK8 subfamily","AMPK subfamily","TAO subfamily","Rho kinase","Leucine-rich repeat kinase (LRRK) family","PAKB subfamily","Abl family","Janus kinase (JakA) family","Type XIV RTKs: RET","Sr
c family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Fak family",
"Ack family","Chromatin modifying enzymes","Nuclear hormone receptors",Atypical,"3.5.1.- Histone deacetylases (HDACs)","Lipid modifying kinases","1H. Liver X receptor-like receptors","STE11 family","D
CAMKL family","RSK family","MAPK-Activated Protein Kinase (MAPKAPK) family","Protein kinase C (PKC) family","Vaccina related kinase (VRK) family","STE7 family","RIO family","1-phosphatidylinositol 4-k
inase family","CASK family","SRPK family","MAST family","Mitogen-activated protein kinases (MAP kinases)","Phosphorylase kinase (PHK) family","Protein kinase G (PKG) family","Myosin Light Chain Kinase
 (MLCK) family","Opsin/rhodopsin kinases","RSK subfamily","MKN subfamily","Eta subfamily","Polo-like kinase (PLK) family","STE20 subfamily","Receptor serine/threonine kinase (RSTK) family","CDK7 subfa
mily","NIMA (never in mitosis gene a)- related kinase (NEK) family","TTK family","RAF family","YSK subfamily","Receptor interacting protein kinase (RIPK) family","RIO1 subfamily","Numb-associated kina
se (NAK) family","KHS subfamily","NKF1 family","Unc-51-like kinase (ULK) family","Casein kinase 2 (CK2) family","MARK subfamily","RIO3 subfamily","FRAY subfamily","JNK subfamily","GEK subfamily","IRE 
family","HIPK subfamily","RIO2 subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","NAK family","NuaK subfamily","QIK subfamily","MELK subfamily","Dyrk2 subfamily","MSK subfamily","Mix
ed Lineage Kinase (MLK) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type I receptor serine/threonine kinases","Type II receptor serine/threonine kinases","Type XIII RTKs: Ephrin re
ceptor family","TAK1 subfamily"}

> <pathway_reactome>
{"Immune System",Disease,"Cell Cycle","Developmental Biology","Cellular responses to external stimuli","Signal Transduction","Gene expression (Transcription)","Programmed Cell Death","Neuronal System"
,Metabolism,"Innate Immune System","Infectious disease",Mitotic,"Nervous system development","Cellular responses to stress","Signaling by GPCR","Cytokine Signaling in Immune system","Diseases of signa
l transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription",Apoptosis,"Signaling by Non-Receptor Tyrosine Kinases","Tran
smission across Chemical Synapses","Metabolism of lipids","Toll-like Receptor Cascades","Leishmania infection","Mitotic G1 phase and G1/S transition","Axon guidance","Cellular Senescence","HIV Infecti
on","GPCR downstream signalling","SARS-CoV Infections","M Phase","Signaling by Interleukins","Signaling by FGFR in disease","Signaling by WNT in cancer","Signaling by NOTCH1 in Cancer","Signaling by N
TRKs","Generic Transcription Pathway","Caspase activation via extrinsic apoptotic signalling pathway","Signaling by PTK6","Mitotic G2-G2/M phases","Neurotransmitter receptors and postsynaptic signal t
ransmission","Sphingolipid metabolism","Toll Like Receptor 4 (TLR4) Cascade","Parasite infection","G1 Phase","RET signaling","Oxidative Stress Induced Senescence","Host Interactions of HIV factors","G
 alpha (q) signalling events","SARS-CoV-1 Infection","Mitotic Metaphase and Anaphase","Interleukin-2 family signaling","Signaling by FGFR1 in disease","Signaling by AMER1 mutants","Signaling by NOTCH1
 HD+PEST Domain Mutants in Cancer","Signaling by NTRK1 (TRKA)","Transcriptional Regulation by TP53","G0 and Early G1","Caspase activation via Dependence Receptors in the absence of ligand","Semaphorin
 interactions","PTK6 promotes HIF1A stabilization","Signaling by ROBO receptors","G2/M Transition","Activation of NMDA receptors and postsynaptic events","Signaling by NTRK3 (TRKC)","Sphingolipid de n
ovo biosynthesis","MyD88-independent TLR4 cascade","Leishmania phagocytosis","Cyclin D associated events in G1","The role of Nef in HIV-1 replication and disease pathogenesis","SARS-CoV-1 Genome Repli
cation and Transcription","Mitotic Anaphase","Interleukin-15 signaling","FGFR1 mutant receptor activation","Truncations of AMER1 destabilize the destruction complex","Constitutive Signaling by NOTCH1 
HD+PEST Domain Mutants","Activation of TRKA receptors","Regulation of TP53 Activity","Sema4D in semaphorin signaling","Activation of RAC1","Centrosome maturation","Post NMDA receptor activation events
","Activated NTRK3 signals through PI3K","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3A-mediated phagocytosis","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin ad
apters","Replication of the SARS-CoV-1 genome","Separation of Sister Chromatids","Signaling by activated point mutants of FGFR1","NGF-independant TRKA activation","Regulation of TP53 Activity through 
Phosphorylation","Sema4D induced cell migration and growth-cone collapse","Nef and signal transduction","Loss of proteins required for interphase microtubule organization from the centrosome","CREB1 p
hosphorylation through NMDA receptor-mediated activation of RAS signaling","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosom
es","Ras activation upon Ca2+ influx through NMDA receptor","Metabolism of RNA","Vesicle-mediated transport","Muscle contraction","Metabolism of proteins",Autophagy,"Signaling by TGFB family members",
"rRNA processing","Signaling by Hedgehog","Membrane Trafficking","Cardiac conduction","Unfolded Protein Response (UPR)",Macroautophagy,"Post-translational protein modification","Metabolism of carbohyd
rates","MAPK family signaling cascades","Signaling by Rho GTPases","Signaling by KIT in disease","Interferon Signaling","Fcgamma receptor (FCGR) dependent phagocytosis","Signaling by BMP","Apoptotic e
xecution phase","rRNA processing in the nucleus and cytosol","Phospholipid metabolism","Hedgehog 'on' state","trans-Golgi Network Vesicle Budding","Ion homeostasis","IRE1alpha activates chaperones","S
elective autophagy",SUMOylation,"Glycogen metabolism","Clathrin-mediated endocytosis","MAPK1/MAPK3 signaling","RHO GTPase Effectors","G alpha (i) signalling events","Drug resistance of KIT mutants","A
ntiviral mechanism by IFN-stimulated genes","Role of phospholipids in phagocytosis","Interferon alpha/beta signaling","HIV Life Cycle","Mitotic Prophase","Toll Like Receptor 5 (TLR5) Cascade","Apoptot
ic cleavage of cellular proteins","Major pathway of rRNA processing in the nucleolus and cytosol","Transcriptional regulation by RUNX2","PI Metabolism","Golgi Associated Vesicle Biogenesis","EPH-Ephri
n signaling",Mitophagy,"SUMO E3 ligases SUMOylate target proteins","Toll Like Receptor 2 (TLR2) Cascade","Glycogen breakdown (glycogenolysis)","Cargo recognition for clathrin-mediated endocytosis","In
terleukin-1 family signaling","RAF/MAP kinase cascade","Leishmania parasite growth and survival","L1CAM interactions","RHO GTPases activate PAKs","Visual phototransduction","Dasatinib-resistant KIT mu
tants","ISG15 antiviral mechanism","Regulation of IFNA signaling","Late Phase of HIV Life Cycle","Nuclear Envelope Breakdown","MyD88 cascade initiated on plasma membrane","Signalling to ERKs","RUNX2 r
egulates bone development","Synthesis of PIPs at the Golgi membrane","Assembly and cell surface presentation of NMDA receptors","EPHB-mediated forward signaling","Receptor Mediated Mitophagy","EPHA-me
diated growth cone collapse","SUMOylation of intracellular receptors","Toll Like Receptor TLR6:TLR2 Cascade","Interleukin-1 signaling","RAS processing","Anti-inflammatory response favouring Leishmania
 parasite infection","Recycling pathway of L1","The phototransduction cascade","Nuclear Envelope (NE) Reassembly","Transcription of the HIV genome","Activation of NIMA Kinases NEK9",NEK6,NEK7,"MAP kin
ase activation","Prolonged ERK activation events","RUNX2 regulates osteoblast differentiation","Activation of RAC1 downstream of NMDARs","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","CD163 
mediating an anti-inflammatory response","IKK complex recruitment mediated by RIP1",Inactivation,"recovery and regulation of the phototransduction cascade","RSK activation","Initiation of Nuclear Enve
lope (NE) Reformation","HIV Transcription Elongation","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","ARMS-mediated activation","Frs2-mediated activation","MAPK
 targets/ Nuclear events mediated by MAP kinases","activated TAK1 mediates p38 MAPK activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Tat-mediated elongation of the HIV-1 tra
nscript","Activation of the AP-1 family of transcription factors","CREB phosphorylation","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{JAK1,JAK2}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{"RUXOLITINIB (INCB018424",941688-05-7,941688057,"INCB018424 Racemic","Ruxotinib Racemate",1160597-27-2,1160597272,(R)-ruxolitinib,(R)ruxolitinib,INCB18424,(S)-Ruxolitinib,(S)Ruxolitinib,Kinome_3200,K
inome3200,Kinome-3200,"Kinome 3200",Kinome_3203,Kinome3203,Kinome-3203,"Kinome 3203",SCHEMBL101279,"US10561657, Ruxolitinib",CHEMBL2002099,SCHEMBL20439527,CHEBI:91405,BDBM433323,SY-INCB018424,S2902,S1
378,"INCB018424  (Ruxolitinib)","S-Ruxolitinib (INCB018424)","Ruxolitinib (INCB018424)"}

> <pdid>
PD003235

> <targets>
{JAK1,JAK2,JAK}

> <classes>
{JAK/STAT}

> <pubchem_cids>
{17754772}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
   10.2945   -1.1254    0.0000 Cl  0  0
    6.4902   -5.2570    0.0000 C   0  0
    6.4931   -3.7570    0.0000 C   0  0
    7.7906   -4.5097    0.0000 C   0  0
    7.7938   -3.0099    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  3  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  2  0
 21 12  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28707

> <plate>
Kinase v5-2

> <well>
N08

> <supplier_cmpd_name>
Akt-I-1,2   (Akti-1/2)

> <ctcr_id>
5980

> <supplier_cmpd_id>
SY-AKT-I-1,2

> <smiles>
Cl.CC(C)(N)c1ccc(cc1)c2nc3ccccc3nc2c4ccccc4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{KTI1,"2 (AKTI-1/2","2 (AKTI1/2",473382-50-2,473382502,"Akt-I-1,2 HCl","AktI1,2 HCl",2-(4-(3-Phenylquinoxalin-2-yl)phenyl)propan-2-amine;hydrochloride,2(4(3Phenylquinoxalin2yl)phenyl)propan2amine;hydr
ochloride,"Akt-I-2 HCl","AktI2 HCl",C23H21N3.HCl,SYN1006,BCP18315,"2-(4-(3-phenylquinoxalin-2-yl)phenyl)propan-2-amine hydrochloride","2(4(3phenylquinoxalin2yl)phenyl)propan2amine hydrochloride",LT007
9,AS-16181,AS16181,Akt-I-1,AktI1,2,"SY-AKT-I-1,2","Akt-I-1,2   (Akti-1/2)"}

> <pdid>

> <targets>
{"AKT 1/2"}

> <classes>
{}

> <pubchem_cids>
{73014064}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
   -1.1509   -2.6325    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    0.7960   -4.3861    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -2.6017    2.9971    0.0000 O   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -0.0080    6.0003    0.0000 C   0  0
   -0.0080    7.5003    0.0000 C   0  0
   -1.3071    8.2503    0.0000 C   0  0
   -2.6061    7.5003    0.0000 N   0  0
   -2.6061    6.0003    0.0000 C   0  0
   -3.9074    5.2525    0.0000 N   0  0
   -5.2060    6.0048    0.0000 C   0  0
   -6.5073    5.2571    0.0000 C   0  0
   -7.8064    6.0070    0.0000 C   0  0
   -9.1055    5.2571    0.0000 C   0  0
   -9.1055    3.7571    0.0000 N   0  0
   -7.8065    3.0070    0.0000 C   0  0
   -6.5075    3.7570    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
  8 26  2  0
 26 27  1  0
 27 28  2  0
 28  2  1  0
 28  6  1  0
M  END
> <name>
UTKinase_V5

> <id>
28708

> <plate>
Kinase v5-2

> <well>
N10

> <supplier_cmpd_name>
Motesanib   (AMG-706)

> <ctcr_id>
2084

> <supplier_cmpd_id>
SY-Motesanib

> <smiles>
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc4ccncc4)ccc12

> <pd_targets>
{KDR,ABL1,FGR,FLT1,FLT4,FLT3,EGFR,SLK,BLK,BRAF,MAP3K19,MAP3K7,MAP3K20,AURKC,RET,FRK,KIT,PDGFRB,YES1,LYN,PDGFRA,STK10,EPHA6,CIT,LCK,FYN,EIF2AK4,ABL2,CSF1R,RIPK2,JAK1,MAP3K2,HCK,PTK6,RAF1,FGFR1,MAP4K4,T
NNI3K,FGFR4,STK35,MAP3K3,DDR1,EPHA7}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","STE protein kinase group","TKL protein kinase group","Other protein kinase group","AGC protein kinase group","Tyrosine protein kinase VEGFR f
amily","Tyrosine protein kinase Abl family","Tyrosine protein kinase Src family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase EGFR family","STE protein kinase STE20 family","TKL pro
tein kinase RAF family","STE protein kinase STE11 family","TKL protein kinase MLK family","Other protein kinase AUR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Eph family","A
GC protein kinase DMPK family","Other protein kinase PEK family","TKL protein kinase RIPK family","Tyrosine protein kinase JakA family","Tyrosine protein kinase FGFR family","Other protein kinase NKF4
 family","Tyrosine protein kinase DDR family","STE protein kinase SLK subfamily","TKL protein kinase TAK1 subfamily","TKL protein kinase MLK subfamily","AGC protein kinase CRIK subfamily","Tyrosine pr
otein kinase SrcA","Other protein kinase GCN2 subfamily","STE protein kinase MEKK2","STE protein kinase MSN subfamily","TKL protein kinase HH498 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","TK: Ty
rosine kinase","STE20 family","TKL: Tyrosine kinase-like","Other protein kinases","DMPK family","STE11 family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","SLK subfamily
","RAF family","STE20 subfamily","Mixed Lineage Kinase (MLK) family","Aurora kinase (Aur) family","Other DMPK family kinases","PEK family","Receptor interacting protein kinase (RIPK) family","MSN subf
amily","NKF4 family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Abl family","Src family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type I RTKs: ErbB (epid
ermal growth factor) receptor family","TAK1 subfamily","MLK subfamily","Type XIV RTKs: RET","Type XIII RTKs: Ephrin receptor family","GCN2 subfamily","Janus kinase (JakA) family","Type V RTKs: FGF (fi
broblast growth factor) receptor family","HH498 subfamily","Type XVI RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Gene expression (Transcription)","Immune System","Developmental Biology","Cellular responses to external stimuli","Cell Cycle","Extracellular matrix organization","Sign
aling by Receptor Tyrosine Kinases","Infectious disease","Signaling by GPCR","RNA Polymerase II Transcription","Innate Immune System","Nervous system development","Intracellular signaling by second me
ssengers","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Rho GTPases","Cellular responses to stress","Cytokine Signaling in Immune system",Mitotic,"MA
PK family signaling cascades","Non-integrin membrane-ECM interactions","Signaling by VEGF","Leishmania infection","Signaling by Insulin receptor","GPCR downstream signalling","Generic Transcription Pa
thway","Signaling by NTRKs","Toll-like Receptor Cascades","Axon guidance","PIP3 activates AKT signaling","Signaling by KIT in disease","Signaling by PDGFR in disease","Neutrophil degranulation","RHO G
TPase Effectors","HIV Infection","Response of EIF2AK4 (GCN2) to amino acid deficiency","Interferon Signaling","Mitotic G1 phase and G1/S transition","MAPK1/MAPK3 signaling","Signaling by FGFR in disea
se","Cellular Senescence","Signaling by FGFR","Signaling by Interleukins","VEGFA-VEGFR2 Pathway","Parasite infection","Leishmania parasite growth and survival","VEGF ligand-receptor interactions","Ins
ulin receptor signalling cascade","G alpha (q) signalling events","Transcriptional regulation by RUNX1","Signaling by NTRK1 (TRKA)","Toll Like Receptor 4 (TLR4) Cascade","RET signaling","PTEN Regulati
on","Drug resistance of KIT mutants","Negative regulation of the PI3K/AKT network","Drug resistance of PDGFR mutants","EPH-Ephrin signaling","RHO GTPases activate CIT","Host Interactions of HIV factor
s","Signaling by ROBO receptors","Transcriptional Regulation by VENTX","Toll Like Receptor 5 (TLR5) Cascade","Antiviral mechanism by IFN-stimulated genes","G1 Phase","RAF/MAP kinase cascade","Signalin
g by FGFR1 in disease","Oxidative Stress Induced Senescence","Signaling by FGFR4","Interleukin-1 family signaling","VEGFR2 mediated cell proliferation","Leishmania phagocytosis","Anti-inflammatory res
ponse favouring Leishmania parasite infection","VEGF binds to VEGFR leading to receptor dimerization","IRS-mediated signalling","Gastrin-CREB signalling pathway via PKC and MAPK","RUNX1 regulates tran
scription of genes involved in BCR signaling","Signalling to ERKs","MyD88-independent TLR4 cascade","Regulation of PTEN stability and activity","Dasatinib-resistant KIT mutants",PI5P,"PP2A and IER3 Re
gulate PI3K/AKT Signaling","Imatinib-resistant PDGFR mutants","EPHA-mediated growth cone collapse","The role of Nef in HIV-1 replication and disease pathogenesis","Role of ABL in ROBO-SLIT signaling",
"MyD88 cascade initiated on plasma membrane","ISG15 antiviral mechanism","Cyclin D associated events in G1","Negative regulation of MAPK pathway","FGFR1 mutant receptor activation","Downstream signali
ng of activated FGFR4","Interleukin-1 signaling","FCGR3A-mediated phagocytosis","FCGR3A-mediated IL10 synthesis","PI3K Cascade","EGFR Transactivation by Gastrin","Prolonged ERK activation events","TRI
F(TICAM1)-mediated TLR4 signaling","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Nef and signal transduction","MAP kinase activation","Negative feed
back regulation of MAPK pathway","Signaling by activated point mutants of FGFR1","FRS-mediated FGFR4 signaling","ARMS-mediated activation","TRAF6-mediated induction of TAK1 complex within TLR4 complex
","Nef Mediated CD4 Down-regulation","activated TAK1 mediates p38 MAPK activation"}

> <broad_targets>
{FLT1,FLT4,KDR,KIT}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{"OTESANIB (AMG706",Motesanib,453562-69-1,453562691,"AMG 706","N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide","N(3,3dimethylindolin6yl)2(pyridin4ylmethylamino)nicotinamide",AMG7
06,UNII-U1JK633AYI,UNIIU1JK633AYI,U1JK633AYI,CHEBI:51098,"453562-69-1 (free base)","453562691 (free base)",C22H23N5O,"Motesanib (USAN:INN)","Motesanib (AMG-706)","Motesanib (AMG706)",Mo,T2288,SY-Motes
anib,"Motesanib   (AMG-706)",MOTESANIB}

> <pdid>
PD012969

> <targets>
{c-Kit,PDGFR,VEGFR,KIT,VEGFR1/2/3}

> <classes>
{}

> <pubchem_cids>
{11667893}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 24  0  0  0  0            999 V2000
   12.1347   -0.9887    0.0000 Cl  0  0
    9.6347   -0.9887    0.0000 Cl  0  0
    2.4090    1.3091    0.0000 C   0  0
    3.8022    0.7533    0.0000 C   0  0
    4.9024    1.7729    0.0000 C   0  0
    6.3855    1.5484    0.0000 N   0  0
    7.1347    0.2489    0.0000 C   0  0
    6.5858   -1.1471    0.0000 C   0  0
    5.1522   -1.5883    0.0000 C   0  0
    3.8990   -0.7508    0.0000 N   0  0
    2.5988   -1.5004    0.0000 S   0  0
    2.5983   -3.0004    0.0000 O   0  0
    3.8975   -2.2510    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    1.2991   -3.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10  4  1  0
 10 11  1  0
 11 12  2  0
 11 13  2  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 24 14  1  0
 24 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28709

> <plate>
Kinase v5-2

> <well>
N12

> <supplier_cmpd_name>
H1152P (Rho Kinase Inhibitor)

> <ctcr_id>
2897

> <supplier_cmpd_id>
SY-H1152P

> <smiles>
Cl.Cl.CC1CNCCCN1S(=O)(=O)c2cccc3cncc(C)c23

> <pd_targets>
{ROCK1,PRKACA,PRKACB,PRKACG,MYLK,LRRK2,ROCK2,CDK2,AURKB,MAP4K2,PDPK1,DCLK1,BRSK1,PLK4,MAP4K4,PHKG2,KDR,AURKA,PRKX,CDK5,SGK2,MARK3,EPHA2,PRKD2,PRKCZ,PRKAA1,PRKG1,MKNK2,CLK4,STK3,LCK,FGFR1,PRKD3,CHEK2,M
ARK2,PRKG2,PRKCD,MINK1,IRAK1,SLK,CLK2,AKT3,PKN2,LIMK1,FLT4,CDK1,AKT1,MAP4K5}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","CAMK protein kinase group","TKL protein kinase group","CMGC protein kinase group","Other protein kinase group","STE protein kinase group","T
K protein kinase group","AGC protein kinase DMPK family","AGC protein kinase PKA family","CAMK protein kinase MLCK family","TKL protein kinase LRRK family","CMGC protein kinase CDK family","Other prot
ein kinase AUR family","STE protein kinase STE20 family","AGC protein kinase PDK1 subfamily","CAMK protein kinase DCAMK1 family","CAMK protein kinase CAMK1 family","Other protein kinase PLK family","C
AMK protein kinase PHk family","Tyrosine protein kinase VEGFR family","AGC protein kinase SGK family","Tyrosine protein kinase Eph family","CAMK protein kinase PKD family","AGC protein kinase PKC fami
ly","AGC protein kinase PKG family","CAMK protein kinase MAPKAPK family","CMGC protein kinase CLK family","Tyrosine protein kinase Src family","Tyrosine protein kinase FGFR family","CAMK protein kinas
e RAD53 family","TKL protein kinase IRAK family","AGC protein kinase AKT family","AGC protein kinase PKN family","TKL protein kinase LISK family","AGC protein kinase ROCK subfamily","CMGC protein kina
se CDC2 subfamily","STE protein kinase KHS subfamily","CAMK protein kinase BRSK subfamily","STE protein kinase MSN subfamily","CMGC protein kinase CDK5 subfamily","CAMK protein kinase MARK subfamily",
"AGC protein kinase PKC iota subfamily","CAMK protein kinase AMPK subfamily","CAMK protein kinase MNK subfamily","STE protein kinase MST subfamily","AGC protein kinase PKC delta subfamily","STE protei
n kinase SLK subfamily","TKL protein kinase LIMK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","CMGC: Containing CDK",
MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","DMPK family","Myosin Light Chain Kinase (MLCK) family","TKL: Tyrosine kinase-like","Cyclin-dependent kina
se (CDK) family","Other protein kinases","STE20 family","PDK1 family","DCAMKL family","CAMK-like (CAMKL) family","Phosphorylase kinase (PHK) family","TK: Tyrosine kinase","Protein kinase A (PKA) famil
y","SGK family","Protein kinase D (PKD) family","Protein kinase C (PKC) family","Protein kinase G (PKG) family","MAPK-Activated Protein Kinase (MAPKAPK) family","CLK family","Akt (Protein kinase B","P
KB) family","Protein kinase N (PKN) family","Rho kinase","Leucine-rich repeat kinase (LRRK) family","CDK1 subfamily","Aurora kinase (Aur) family","KHS subfamily","BRSK subfamily","Polo-like kinase (PL
K) family","MSN subfamily","Receptor tyrosine kinases (RTKs)","CDK5 subfamily","MARK subfamily","Iota subfamily","AMPK subfamily","MKN subfamily","MST subfamily","Non-receptor tyrosine kinases (nRTKs)
","CHK1 subfamily","Delta subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","SLK subfamily","LIM domain kinase (LISK) family","Type IV RTKs: VEGF (vascular endothelial growth factor)
 receptor family","Type XIII RTKs: Ephrin receptor family","Src family","Type V RTKs: FGF (fibroblast growth factor) receptor family","LIMK subfamily"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction","Gene expression (Transcription)","Cell Cycle","Cellular responses to external stimuli",Metabolism,Disease,"Transport of small molecules",Hemostasis,"Imm
une System","Nervous system development","Signaling by Rho GTPases","Signaling by Non-Receptor Tyrosine Kinases","RNA Polymerase II Transcription",Mitotic,"Cellular responses to stress","Metabolism of
 carbohydrates","Signaling by Receptor Tyrosine Kinases","Infectious disease","Ion channel transport","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of 
lipids","Signaling by Nuclear Receptors","Platelet homeostasis","Signaling by Hippo","MAPK family signaling cascades","Intracellular signaling by second messengers","Innate Immune System","Axon guidan
ce","RHO GTPase Effectors","Signaling by PTK6","Generic Transcription Pathway","M Phase","Mitotic G2-G2/M phases","Cellular Senescence","Glycogen metabolism","Signaling by VEGF","Leishmania infection"
,"Stimuli-sensing channels","Oncogenic MAPK signaling","Sphingolipid metabolism","ESR-mediated signaling","Nitric oxide stimulates guanylate cyclase","HIV Infection","Signaling by FGFR in disease","MA
PK1/MAPK3 signaling","DAG and IP3 signaling","Toll-like Receptor Cascades","Regulation of mitotic cell cycle","Semaphorin interactions","RHO GTPases activate PAKs","PTK6 promotes HIF1A stabilization",
"Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase","G2/M Transition","Oxidative Stress Induced Senescence","Glycogen breakdown (glycogenolysis)","VEGFA-VEGFR2 Pathway","Leishmania p
arasite growth and survival","Signaling by RAS mutants","EPH-Ephrin signaling","Sphingolipid de novo biosynthesis","Extra-nuclear estrogen signaling","cGMP effects","Host Interactions of HIV factors",
"Signaling by FGFR1 in disease","RAF/MAP kinase cascade","CaM pathway","Toll Like Receptor 5 (TLR5) Cascade","RHO GTPases activate PKNs","VEGF ligand-receptor interactions","APC/C-mediated degradation
 of cell cycle proteins","Sema4D in semaphorin signaling","Regulation of TP53 Activity","Mitotic Anaphase","Centrosome maturation","VEGFR2 mediated cell proliferation","Anti-inflammatory response favo
uring Leishmania parasite infection","Signaling downstream of RAS mutants","EPHA-mediated growth cone collapse","Estrogen-stimulated signaling through PRKCZ","The role of Nef in HIV-1 replication and 
disease pathogenesis","FGFR1 mutant receptor activation","RAS processing","Calmodulin induced events","MyD88 cascade initiated on plasma membrane","VEGF binds to VEGFR leading to receptor dimerization
","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Expression and Degradation","Separation of
 Sister Chromatids","Loss of proteins required for interphase microtubule organization from the centrosome","Regulation of TP53 Activity through Phosphorylation","ADORA2B mediated anti-inflammatory cy
tokines production","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Signaling by activated point mutants of FGFR1","MAP kinase activation","APC/C:Cdc2
0 mediated degradation of mitotic proteins","Regulation of TP53 Degradation","Loss of Nlp from mitotic centrosomes","Nef Mediated CD4 Down-regulation","activated TAK1 mediates p38 MAPK activation","AP
C:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{871543-07-6,871543076,SCHEMBL507872,HMS3746C07,MFCD06411451,SY-H1152P,"H1152P (Rho Kinase Inhibitor)"}

> <pdid>
PD004930

> <targets>
{ROCK}

> <classes>
{}

> <pubchem_cids>
{66707179}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  1  0            999 V2000
   13.1886   -3.6010    0.0000 Cl  0  0
    4.6388   -8.1760    0.0000 N   0  0
    3.2151   -7.7040    0.0000 C   0  0
    2.0947   -8.7014    0.0000 O   0  0
    2.9122   -6.2341    0.0000 N   0  0
    4.0312   -5.2378    0.0000 C   0  0
    5.4984   -5.5497    0.0000 C   0  0
    6.2484   -4.2507    0.0000 C   0  0
    5.2447   -3.1359    0.0000 S   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    7.7410   -4.0938    0.0000 C   0  0
    8.7076   -5.2343    0.0000 C   0  0
   10.1833   -4.9657    0.0000 C   0  0
   10.6886   -3.5534    0.0000 C   0  0
    9.7181   -2.4097    0.0000 C   0  0
   10.2234   -0.9973    0.0000 F   0  0
    8.2423   -2.6783    0.0000 C   0  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10  6  2  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 14 13  1  6
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
  8 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 26 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28710

> <plate>
Kinase v5-2

> <well>
N14

> <supplier_cmpd_name>
AZD7762

> <ctcr_id>
7726

> <supplier_cmpd_id>
SY-AZD7762

> <smiles>
Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)c3cccc(F)c3

> <pd_targets>
{CHEK1,CHEK2,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","CAMK protein kinase group","Voltage-gated potassium channel","CAMK protein kinase CAMK1 family","CAMK pr
otein kinase RAD53 family","CAMK protein kinase CHK1 subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels","Kinases (EC 2.7.x.x)","Voltage-gated ion channels","CAMK: Calcium/calmodulin-dependent protein kinases","Potassium channels","CAMK-like (CAMKL) family","Voltage-gated potassiu
m channels","CHK1 subfamily"}

> <pathway_reactome>
{"DNA Repair","Gene expression (Transcription)","Muscle contraction","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Cardiac conduction","Homology Directed Repair","Generic Transcr
iption Pathway","Phase 3 - rapid repolarisation","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Transcriptional Regulation by TP53","HDR through Homologous Recombinatio
n (HRR)","Regulation of TP53 Activity","Homologous DNA Pairing and Strand Exchange","Regulation of TP53 Expression and Degradation","Presynaptic phase of homologous DNA pairing and strand exchange","R
egulation of TP53 Degradation"}

> <broad_targets>
{CHEK1,CHEK2}

> <broad_moa>
{"CHK inhibitor"}

> <synonyms>
{"AZD 7762 hydrochloride","AZD7762 HCl",1246094-78-9,1246094789,"1246094-78-9 (HCl)","1246094789 (HCl)",C17H19FN4O2S,MLS006010750,SCHEMBL19457662,BCP25387,1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluor
ophenyl)thiophen-3-yl)urea,1(2((S)piperidin3ylcarbamoyl)5(3fluorophenyl)thiophen3yl)urea,AKOS024458535,SMR004701703,AZD-77,AZD77,SY-AZD7762,AZD7762}

> <pdid>
PD003297

> <targets>
{CHK}

> <classes>
{}

> <pubchem_cids>
{56972142}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 27  0  0  0  0            999 V2000
   17.4297   -5.4876    0.0000 H   0  3
   14.9297   -5.4876    0.0000 Cl  0  5
   12.4289  -10.2253    0.0000 C   0  0
   11.1294  -10.9745    0.0000 C   0  0
   11.1290  -12.4745    0.0000 C   0  0
   12.4281  -11.7250    0.0000 C   0  0
    9.8319  -10.2254    0.0000 C   0  0
    9.6751   -8.7336    0.0000 O   0  0
    8.2168   -8.4417    0.0000 C   0  0
    7.6035   -7.0719    0.0000 C   0  0
    6.1107   -6.9172    0.0000 S   0  0
    5.4984   -5.5497    0.0000 C   0  0
    4.0312   -5.2378    0.0000 S   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.2447   -3.1359    0.0000 N   0  0
    6.2484   -4.2507    0.0000 C   0  0
    7.4579   -9.7208    0.0000 N   0  0
    8.4616  -10.8355    0.0000 C   0  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  4  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
 14 24  2  0
 24 25  1  0
 25 12  2  0
  9 26  2  0
 26 27  1  0
 27  7  2  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28711

> <plate>
Kinase v5-2

> <well>
N16

> <supplier_cmpd_name>
SNS-032 (BMS387032)

> <ctcr_id>
771

> <supplier_cmpd_id>
SY-SNS-032

> <smiles>
[H+].[Cl-].CC(C)(C)c1oc(CSc2sc(NC(=O)C3CCNCC3)nc2)nc1

> <pd_targets>
{MAPK6,BRSK2,MAK,HIPK2,CDK1,CIT,CDK9,CCNB1,FLT3,CSNK1E,AURKA,CDKL2,MAP3K7,CCNE1,CDK2,MKNK1,CDK19,CDK8,AURKC,CLK1,CDK7,CLK2,CDK5,CDK3,CDK16,CDK14,DCLK3,DCLK1,STK17A,DYRK1B,MAPK4,CCNH,CSNK1D,DYRK2,DYRK1
A,MYLK3,CCND1,CDK4,IRAK3,CCNE2,PRKD1,CDKL5,HIPK3,RIOK2,PRKD3,GSK3A,MELK,MAPK10,CDK11A,CLK4,DCLK2,STK36,GAK,CDK17,PAK3,CDK15,HIPK1,PHKG2,MKNK2,MYLK2,COQ8B,TAOK3,NUAK2,MAPK15,PRKD2,TGFBR2,PHKG1,MYLK4,PR
KAA1,BRAF,CASK,TAOK2,MYLK,CSNK1A1,CCND2,CCND3,MAPK7,GSK3B,MAST1,TAOK1,RPS6KA5,CDK11B,CCNB2,CCNB3,CDKL3,CCNT1,ULK1,CILK1,CDK13,FLT1,CDK18,CCNA2,MNAT1,CDK5R1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CAMK protein kinase group","AGC protein kinase group","TK protein kinase group","CK1 protein kinase group","Other protein kinase group","TK
L protein kinase group","Atypical protein kinase group","STE protein kinase group","CMGC protein kinase MAPK family","CAMK protein kinase CAMK1 family","CMGC protein kinase RCK family","CMGC protein k
inase DYRK family","CMGC protein kinase CDK family","AGC protein kinase DMPK family","Tyrosine protein kinase PDGFR family","CK1 protein kinase CK1 family","Other protein kinase AUR family","CMGC prot
ein kinase CDKL family","TKL protein kinase MLK family","CAMK protein kinase MAPKAPK family","CMGC protein kinase CLK family","CAMK protein kinase DCAMK1 family","CAMK protein kinase DAPK family","CAM
K protein kinase MLCK family","TKL protein kinase IRAK family","CAMK protein kinase PKD family","Atypical protein kinase RIO family","CMGC protein kinase GSK family","Other protein kinase ULK family",
"Other protein kinase NAK family","STE protein kinase STE20 family","CAMK protein kinase PHk family","Atypical protein kinase ABC1 family","TKL protein kinase STKR family","TKL protein kinase RAF fami
ly","AGC protein kinase MAST family","AGC protein kinase RSK family","Tyrosine protein kinase VEGFR family","CMGC protein kinase ERK3","CAMK protein kinase BRSK subfamily","CMGC protein kinase MAK","C
MGC protein kinase HIPK subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase CRIK subfamily","CMGC protein kinase CDK9 subfamily","TKL protein kinase TAK1 subfamily","CAMK protein kinas
e MNK subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase TAIRE subfamily","CMGC protein kinase PFTAIRE","CMG
C protein kinase Dyrk1 subfamily","CMGC protein kinase Dyrk2 subfamily","Atypical protein kinase RIO2 subfamily","CAMK protein kinase MELK subfamily","CMGC protein kinase JNK subfamily","CMGC protein 
kinase PITSLRE subfamily","CMGC protein kinase PCTAIRE","STE protein kinase PAKA subfamily","Atypical protein kinase ABC1-A subfamily","STE protein kinase TAO subfamily","CAMK protein kinase NuaK subf
amily","TKL protein kinase STKR Type 2 subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase ERK5","AGC protein kinase MSK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","AGC: Containing PKA",PKG,"PKC fami
lies","Receptor kinases","CK1: Casein kinase 1",Atypical,"STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Mitogen-activated protein kinases (MAP kinases)","CAMK-like (CAMKL) famil
y","RCK family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Cyclin-dependent kinase (CDK) family","DMPK family","TK: Tyrosine kinase","Casein kinase 1 (CK1) family"
,"Other protein kinases","Cyclin-dependent kinase-like (CDKL) family","TKL: Tyrosine kinase-like","MAPK-Activated Protein Kinase (MAPKAPK) family","CLK family","DCAMKL family","Death-associated kinase
 (DAPK) family","Myosin Light Chain Kinase (MLCK) family","Protein kinase D (PKD) family","RIO family","Glycogen synthase kinase (GSK) family","STE20 family","Phosphorylase kinase (PHK) family","ABC1 
family","CASK family","MAST family","RSK family","ERK subfamily","BRSK subfamily","HIPK subfamily","CDK1 subfamily","Other DMPK family kinases","CDK9 subfamily","Receptor tyrosine kinases (RTKs)","Aur
ora kinase (Aur) family","Mixed Lineage Kinase (MLK) family","MKN subfamily","CDK8 subfamily","CDK7 subfamily","CDK5 subfamily","TAIRE subfamily","Dyrk1 subfamily","Dyrk2 subfamily","Interleukin-1 rec
eptor-associated kinase (IRAK) family","CDK4 subfamily","RIO2 subfamily","GSK subfamily","MELK subfamily","JNK subfamily","PITSLRE subfamily","Unc-51-like kinase (ULK) family","Numb-associated kinase 
(NAK) family","PAKA subfamily","ABC1-B subfamily","TAO subfamily","NuaK subfamily","Erk7 subfamily","Receptor serine/threonine kinase (RSTK) family","AMPK subfamily","RAF family","MSK subfamily","CRK7
 subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","TAK1 subfamily","Type II receptor serine/threonine kinases","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family
"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Cell Cycle",Disease,"Immune System",Metabolism,"Metabolism of RNA","Vesicle-mediated transport","Developmental Biology","Neuronal System",Auto
phagy,"MAPK family signaling cascades","RNA Polymerase II Transcription",Mitotic,"Signaling by Rho GTPases","Infectious disease","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Metabo
lism of lipids","Diseases of signal transduction by growth factor receptors and second messengers","rRNA processing","Membrane Trafficking","Nervous system development","Metabolism of carbohydrates","
Transmission across Chemical Synapses",Macroautophagy,"MAPK6/MAPK4 signaling","Generic Transcription Pathway","Regulation of mitotic cell cycle","RHO GTPase Effectors","HIV Infection","Signaling by In
sulin receptor","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Signaling by FGFR","Regulation of lipid metabolism by PPARalpha","Signaling by NOTCH1 in Cancer","Mitotic G1 phase and G1/S tran
sition","Sphingolipid metabolism","rRNA processing in the nucleus and cytosol","SARS-CoV Infections","trans-Golgi Network Vesicle Budding","Axon guidance","Glycogen metabolism","Signaling by TGF-beta 
Receptor Complex in Cancer","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by WNT in cancer","M Phase","Selective autophagy","Signaling by VEGF","Tra
nscriptional Regulation by TP53","APC/C-mediated degradation of cell cycle proteins","RHO GTPases activate CIT","HIV Life Cycle","Insulin receptor signalling cascade","G2/M Transition","Toll Like Rece
ptor 4 (TLR4) Cascade","Signaling by FGFR4","PPARA activates gene expression","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","G0 and Early G1","Toll Like Receptor 2 (TLR2) Cascade","Sphingolip
id de novo biosynthesis","G1 Phase","Major pathway of rRNA processing in the nucleolus and cytosol","SARS-CoV-1 Infection","Toll Like Receptor 5 (TLR5) Cascade","Golgi Associated Vesicle Biogenesis","
EPH-Ephrin signaling","Glycogen breakdown (glycogenolysis)","Loss of Function of SMAD2/3 in Cancer","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","RHO GTPases acti
vate PAKs","Signaling by AMER1 mutants","Mitotic Metaphase and Anaphase",Mitophagy,"VEGF ligand-receptor interactions","Regulation of TP53 Activity","Activation of APC/C and APC/C:Cdc20 mediated degra
dation of mitotic proteins","Late Phase of HIV Life Cycle","IRS-mediated signalling","Centrosome maturation","MyD88-independent TLR4 cascade","Negative regulation of FGFR4 signaling","Constitutive Sig
naling by NOTCH1 HD+PEST Domain Mutants","Toll Like Receptor TLR6:TLR2 Cascade","Cyclin D associated events in G1","SARS-CoV-1 Genome Replication and Transcription","MyD88 cascade initiated on plasma 
membrane","Ephrin signaling","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Signalling to ERKs","Assembly and cell surface presentation of NMDA receptors","Truncations of AMER1 destabilize the des
truction complex","Mitotic Anaphase","Receptor Mediated Mitophagy","TP53 Regulates Transcription of DNA Repair Genes","VEGF binds to VEGFR leading to receptor dimerization","Regulation of TP53 Activit
y through Phosphorylation","APC/C:Cdc20 mediated degradation of mitotic proteins","Transcription of the HIV genome","PI3K Cascade","Loss of proteins required for interphase microtubule organization fr
om the centrosome","TRIF(TICAM1)-mediated TLR4 signaling","Spry regulation of FGF signaling","Regulation of TP53 Expression and Degradation","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Re
plication of the SARS-CoV-1 genome","MAP kinase activation","Recruitment of mitotic centrosome proteins and complexes","Prolonged ERK activation events","Separation of Sister Chromatids","APC:Cdc20 me
diated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","HIV Transcription Elongation","Loss of Nlp from mitotic centrosomes","TRAF6-mediated induction of TAK1 com
plex within TLR4 complex","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Tat
-mediated elongation of the HIV-1 transcript","Activation of the AP-1 family of transcription factors","ERK/MAPK targets","CREB phosphorylation","Formation of HIV-1 elongation complex containing HIV-1
 Tat","ERKs are inactivated"}

> <broad_targets>
{CDK2,CDK7,CDK9}

> <broad_moa>
{"CDK inhibitor","cell cycle inhibitor","MCL1 inhibitor"}

> <synonyms>
{"NS032 (BMS387032",345627-90-9,345627909,"SNS-032 HCl","SNS032 HCl","BMS387032 HCl","SNS-032 hydrochloride","SNS032 hydrochloride",C17H24N4O2S2.HCl,SNS-032.HCL/,SNS032.HCL/,SCHEMBL20583046,SYN1080,BC
P02418,ABP000851,AS-16235,AS16235,"SNS-032 (BMS387032)","SNS032 (BMS387032)",FT-0765829,FT0765829,Z-3204,Z3204,627D909,J-523351,J523351,"SNS032 HCl;SNS-032 HCl;BMS3","SNS032 HCl;SNS032 HCl;BMS3",SY-SN
S-032}

> <pdid>
PD003662

> <targets>
{CDK}

> <classes>
{}

> <pubchem_cids>
{9823239}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
   10.7810    3.2327    0.0000 C   0  0
    9.3959    3.8084    0.0000 C   0  0
    9.2023    5.2958    0.0000 C   0  0
    8.2035    2.8969    0.0000 C   0  0
    8.3970    1.4094    0.0000 O   0  0
    6.8176    3.4729    0.0000 N   0  0
    5.6273    2.5630    0.0000 C   0  0
    4.1890    2.9887    0.0000 N   0  0
    3.3397    1.7523    0.0000 C   0  0
    4.2568    0.5878    0.0000 C   0  0
    5.6669    1.0635    0.0000 S   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 Cl  0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
    4.8054   -4.6666    0.0000 C   0  0
    3.9200   -5.8774    0.0000 F   0  0
    6.2966   -4.8284    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  7  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 12  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 17  1  0
 23 24  1  0
 14 25  1  0
 25 26  1  0
 25 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28712

> <plate>
Kinase v5-2

> <well>
N18

> <supplier_cmpd_name>
BMS-5

> <ctcr_id>
3545

> <supplier_cmpd_id>
SY-BMS-5

> <smiles>
CC(C)C(=O)Nc1ncc(s1)c2cc(nn2c3c(Cl)cccc3Cl)C(F)F

> <pd_targets>
{LIMK1,LIMK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase LISK family","TKL protein kinase LIMK subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","LIM domain kinase (LISK) family","LIMK subfamily"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Semaphorin interactions","Sema4D in semaphorin signaling","Sema4D induced cell migration and growth-cone collapse"}

> <broad_targets>
{LIMK1}

> <broad_moa>
{"LIM kinase inhibitor"}

> <synonyms>
{MS,BMS-5,BMS5,1338247-35-0,1338247350,"LIMKi 3","BMS 5","LIMKI-3 (BMS-5)","LIMKI3 (BMS5)",LIMKi3,LIMKi-3,"LIM Kinase Inhibitor I",C17H14Cl2F2N4OS,GTPL9839,CHEMBL2141887,SCHEMBL15543888,EX-A934,EXA934
,SYN1024,CHEBI:138670,HMS3244I07,HMS3244I08,HMS3244J07,HMS3743I19,BCP17223,MFCD17019327,ZINC,T4598,SY-BMS-5}

> <pdid>
PD038518

> <targets>
{LIMK,"LIM Kinase (LIMK)"}

> <classes>
{Cell Cycle/DNA Damage}

> <pubchem_cids>
{56965901}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    9.6354    0.1696    0.0000 Cl  0  0
    1.3223    0.6304    0.0000 C   0  0
    2.4802    1.5840    0.0000 N   0  0
    3.9173    1.2212    0.0000 C   0  0
    4.7442    2.4586    0.0000 C   0  0
    3.7980    3.6215    0.0000 C   0  0
    4.0294    5.1036    0.0000 C   0  0
    2.8617    6.0450    0.0000 C   0  0
    1.4625    5.5045    0.0000 C   0  0
    1.2310    4.0224    0.0000 C   0  0
    2.3988    3.0810    0.0000 C   0  0
    4.5721   -0.1292    0.0000 C   0  0
    6.0299   -0.3989    0.0000 C   0  0
    6.2649   -1.8685    0.0000 C   0  0
    7.5973   -2.5575    0.0000 O   0  0
    4.9193   -2.5313    0.0000 N   0  0
    3.8731   -1.4563    0.0000 C   0  0
    2.3885   -1.6709    0.0000 O   0  0
    7.1840    0.5604    0.0000 C   0  0
    7.0865    2.0564    0.0000 C   0  0
    5.9087    2.9853    0.0000 C   0  0
    6.1243    4.4697    0.0000 C   0  0
    4.9478    5.4015    0.0000 C   0  0
    5.1654    6.8857    0.0000 N   0  0
    7.5176    5.0252    0.0000 C   0  0
    8.6954    4.0964    0.0000 C   0  0
    8.4798    2.6119    0.0000 N   0  0
    9.4384    1.4592    0.0000 C   0  0
   10.9362    1.4007    0.0000 C   0  0
   11.6344    0.0731    0.0000 C   0  0
   10.8337   -1.1953    0.0000 C   0  0
    9.3348   -1.1361    0.0000 C   0  0
    8.6378    0.1908    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  3  1  0
 11  6  1  0
  4 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 12  1  0
 17 18  2  0
 13 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 22 25  1  0
 25 26  1  0
 26 27  1  0
 27 20  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 19  1  0
 33 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28713

> <plate>
Kinase v5-2

> <well>
N20

> <supplier_cmpd_name>
Bisindoylmaleimide X  (Ro 31-8425)

> <ctcr_id>
1387

> <supplier_cmpd_id>
SY-Bisindoylmaleimide X

> <smiles>
Cl.Cn1c(cc2ccccc12)C3=C(C(=O)NC3=O)c4c5CC(CN)CCn5c6ccccc46

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{24172587,1241725-87-0,1241725870,"Bisindoylmaleimide X - HCl salt (RO 31-8425)","Bisindoylmaleimide X  HCl salt (RO 318425)",J-510782,J510782,"SY-Bisindolylmaleimide X","Bisindoylmaleimide X  (Ro 31-
8425)"}

> <pdid>

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{73357693}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Br  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -7.8010    1.4796    0.0000 N   0  0
   -9.0971    0.7229    0.0000 C   0  0
   -9.0893   -0.7771    0.0000 O   0  0
  -10.4010    1.4661    0.0000 N   0  0
  -11.7502    0.8404    0.0000 C   0  0
  -12.7578    1.9516    0.0000 C   0  0
  -12.0123    3.2533    0.0000 C   0  0
  -10.5440    2.9465    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.7508   -7.4791    0.0000 C   0  0
   -4.2191   -7.7859    0.0000 N   0  0
   -4.9646   -6.4843    0.0000 C   0  0
   -3.9570   -5.3730    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 13  1  0
  9 18  2  0
 18 19  1  0
 19 20  2  0
 20  7  1  0
  5 21  1  0
 21 22  2  0
 22  2  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28714

> <plate>
Kinase v5-2

> <well>
N22

> <supplier_cmpd_name>
BX912

> <ctcr_id>
11409

> <supplier_cmpd_id>
SY-BX912

> <smiles>
Brc1cnc(Nc2cc(NC(=O)N3CCCC3)ccc2)nc1NCCc1cnc[nH]1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{CDK2,CHEK1,GSK3B,KDR,PDK1,PDPK1}

> <broad_moa>
{"pyruvate dehydrogenase kinase inhibitor"}

> <synonyms>
{BRD-K49669041-001-01-9,BRDK49669041001019,Q27075611,BX-912,BX912,702674-56-4,702674564,"BX 912",C20H23BrN8O,"CID 11754511",cc-391,cc391,MLS006011015,GTPL8007,SCHEMBL3869633,CHEMBL3916849,SCHEMBL15825
412,BDBM17052,CHEBI:91357,AOB2905,DTXSID30471901,EX-A945,EXA945,SYN1027,BCPP000309,HMS3244G1,T1837}

> <pdid>

> <targets>
{CDK2/CyclinE,Chk1,PDK1,PKA,VEGFR2?(KDR)}

> <classes>
{Angiogenesis,"Cell Cycle/Checkpoint","GPCR/G Protein","PI3K/Akt/mTOR signaling","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{11754511}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 21  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -6.4996    5.2432    0.0000 O   0  0
   -7.7985    2.9932    0.0000 C   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -6.4994   -0.7568    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 16 17  2  0
 17 11  1  0
 17 18  1  0
  8 19  1  0
 19 20  2  0
 20  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28715

> <plate>
Kinase v5-2

> <well>
P04

> <supplier_cmpd_name>
AG957

> <ctcr_id>
3175

> <supplier_cmpd_id>
SY-AG957

> <smiles>
COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1

> <pd_targets>
{HKDC1}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{140674-76-6,140674766,"140674 76 6","Tyrphostin AG957","methyl 4-((2,5-dihydroxyphenyl)methylamino)benzoate","methyl 4((2,5dihydroxyphenyl)methylamino)benzoate","methyl 4 ((2,5 dihydroxyphenyl)methyl
amino)benzoate",ag957,"Benzoic acid",4-(((2,4(((2,5-dihy,5dihy,NSC654705,SY-AG957,"NSC 654705",AG957,"AG 957"}

> <pdid>
PD011488

> <targets>
{PTK}

> <classes>
{}

> <pubchem_cids>
{2064}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 N   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -7.7884   -1.5181    0.0000 F   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -5.1821   -3.0099    0.0000 N   0  0
   -3.8787   -3.7540    0.0000 C   0  0
   -3.8682   -5.2539    0.0000 C   0  0
   -2.5640   -5.9949    0.0000 C   0  0
   -1.2702   -5.2360    0.0000 C   0  0
   -1.2805   -3.7360    0.0000 C   0  0
   -2.5847   -2.9950    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 13 21  2  0
 21  8  1  0
  6 22  1  0
 22 23  2  0
 23  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28716

> <plate>
Kinase v5-2

> <well>
P06

> <supplier_cmpd_name>
Dianilinopyrimidine_01

> <ctcr_id>
6211

> <supplier_cmpd_id>
SY-Dianilinopyrimidine_01

> <smiles>
NCc1ccc(Nc2ncc(F)c(Nc3ccccc3)n2)cc1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{IANILINOPYRIMIDINE0,IANILINOPYRIMIDINE-0,"IANILINOPYRIMIDINE 0",916603-07-1,916603071,"N2-(4-(Aminomethyl)phenyl)-5-fluoro-N4-phenylpyrimidine-2,4-diamine","N2(4(Aminomethyl)phenyl)5fluoroN4phenylpyr
imidine2,4diamine",CZC-8004,CZC8004,Dianilinopyrimidine_01,Dianilinopyrimidine01,Dianilinopyrimidine-01,"Dianilinopyrimidine 01","2-N-(4-(aminomethyl)phenyl)-5-fluoro-4-N-phenylpyrimidine-2,4-diamine"
,"2N(4(aminomethyl)phenyl)5fluoro4Nphenylpyrimidine2,4diamine",CZC-00008004,CZC00008004,N(2)-(4-(aminomethyl)phe,N(2)(4(aminomethyl)phe,SY-Dianilinopyrimidine_01}

> <pdid>
PD017965

> <targets>
{pan-TK}

> <classes>
{}

> <pubchem_cids>
{15980598}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    2.5951   -3.0031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1953   -1.5031    0.0000 N   0  0
   -5.1932   -3.0039    0.0000 C   0  0
   -6.4896   -3.7585    0.0000 C   0  0
   -6.4844   -5.2585    0.0000 C   0  0
   -5.1828   -6.0040    0.0000 C   0  0
   -3.8863   -5.2495    0.0000 C   0  0
   -2.5847   -5.9950    0.0000 Cl  0  0
   -3.8915   -3.7495    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -5.1962    3.0000    0.0000 C   0  0
   -3.8971    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 19 13  1  0
 11 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25  7  1  0
 25 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28717

> <plate>
Kinase v5-2

> <well>
P08

> <supplier_cmpd_name>
CX-4945

> <ctcr_id>
4306

> <supplier_cmpd_id>
SY-CX-4945

> <smiles>
OC(=O)c1ccc2c(c1)nc(Nc3cccc(Cl)c3)c4ccncc24

> <pd_targets>
{CSNK2A1,CSNK2A2,CSNK2A3,CSNK2B,DYRK1A,DYRK1B,TBK1,PIM1,CCNB1,CCNB2,CCNB3,CDK1,DAPK3,CLK2,PIM2,CLK3,HIPK3,FLT3,CCNE1,CDK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Protein kinase regulatory subunit","Other protein kinase group","CMGC protein kinase group","CAMK protein kinase group","TK protein kinase group","Other protein kinase
 CK2 family","CMGC protein kinase DYRK family","Other protein kinase IKK family","CAMK protein kinase PIM family","CMGC protein kinase CDK family","CAMK protein kinase DAPK family","CMGC protein kinas
e CLK family","Tyrosine protein kinase PDGFR family","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase HIPK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Dual-specificit
y tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Other protein kinases","PIM family","Death-associated kinase (DAPK) family","CLK family","TK: Tyrosine kinase","Dyrk1 subfamily","Casein
 kinase 2 (CK2) family","IKK family","HIPK subfamily","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)","Immune System",Disease,"Programmed Cell Death","Signal Transduction",Mitotic,"RNA Polymerase II Transcription","Innate Immune System","Diseases of sign
al transduction by growth factor receptors and second messengers",Apoptosis,"Signaling by Receptor Tyrosine Kinases","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Toll-like R
eceptor Cascades","FLT3 signaling in disease","Caspase activation via extrinsic apoptotic signalling pathway","Signaling by Insulin receptor","G0 and Early G1","Transcriptional Regulation by TP53","To
ll Like Receptor 4 (TLR4) Cascade","Signaling by FLT3 ITD and TKD mutants","Caspase activation via Dependence Receptors in the absence of ligand","Insulin receptor signalling cascade","Regulation of T
P53 Activity","MyD88-independent TLR4 cascade","STAT5 activation downstream of FLT3 ITD mutants","IRS-mediated signalling","Regulation of TP53 Activity through Phosphorylation","TRIF(TICAM1)-mediated 
TLR4 signaling","PI3K Cascade","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"}

> <broad_targets>
{CSNK2A1,CSNK2A2,DAPK3,HIPK3}

> <broad_moa>
{"casein kinase inhibitor"}

> <synonyms>
{X494,Silmitasertib,1009820-21-6,1009820216,CX-4945,CX4945,"5-((3-Chlorophenyl)amino)benzo(c)(2,6)naphthyridine-8-carboxylic acid","5((3Chlorophenyl)amino)benzo(c)(2,6)naphthyridine8carboxylic acid","
CX-4945 (Silmitasertib)","CX4945 (Silmitasertib)","CX 4945",UNII-C6RWP0N0L2,UNIIC6RWP0N0L2,"5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid","5(3chlorophenylamino)benzo(c)(2,6)naph
thyridine8carboxylic acid",5-((3-chlo,5((3chlo,T2259,S2248,SY-CX-4945,silmitasertib}

> <pdid>
PD003261

> <targets>
{"Casein Kinase",Others,PKC,CK2}

> <classes>
{Others}

> <pubchem_cids>
{24748573}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    9.0983   -0.7368    0.0000 C   0  0
    7.8003   -1.4887    0.0000 N   0  0
    7.8029   -2.9887    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    6.5005   -2.2411    0.0000 C   0  0
    5.2029   -2.9932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.0591   -4.0114    0.0000 C   0  0
    0.0033   -5.0704    0.0000 C   0  0
    1.0623   -4.0081    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -0.3115    2.9665    0.0000 C   0  0
    0.6928    4.0817    0.0000 C   0  0
    0.3384    5.5341    0.0000 C   0  0
    1.4233    6.5700    0.0000 C   0  0
    2.8628    6.1485    0.0000 C   0  0
    3.2175    4.6910    0.0000 C   0  0
    2.1327    3.6551    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  5  7  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 16  1  0
 13 20  2  0
 20 21  1  0
 21 22  2  0
 22 12  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28718

> <plate>
Kinase v5-2

> <well>
P10

> <supplier_cmpd_name>
Akt-I-1  (Akti-1)

> <ctcr_id>
1566

> <supplier_cmpd_id>
SYAKT-I-1

> <smiles>
CN(C)CC(C)(C)CNc1nn2c(cc1C3CCC3)nnc2c4ccccc4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"KTI1 (AKTI1",AS-16180,AS16180,BCP01941,ABP000412,ZINC38446036,NCGC00345822-01,NCGC0034582201,NCGC00345822-02,NCGC0034582202,AKT-I-1,AKTI1,473382-39-7,473382397,Akt-l-1,Aktl1,C22H30N6,PubChem22402,Ak
t-l-1/,Aktl1/,SCHEMBL5846931,CHEMBL3184502,DTXSID80437693,SYN1005,HMS3244P04,HMS3244P08,HMS3244P12,FT-0710211,FT0710211,Y0276,Z-,Z,SYAKT-I-1,"Akt-I-1  (Akti-1)"}

> <pdid>
PD118827

> <targets>
{AKT-1}

> <classes>
{}

> <pubchem_cids>
{10271028}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
    9.4342   -9.8030    0.0000 C   0  0
    8.6883   -8.5016    0.0000 N   0  0
    9.4424   -7.2050    0.0000 C   0  0
    8.6966   -5.9036    0.0000 C   0  0
    7.1965   -5.8987    0.0000 N   0  0
    6.4425   -7.1955    0.0000 C   0  0
    7.1883   -8.4969    0.0000 C   0  0
    6.4482   -4.5978    0.0000 C   0  0
    7.2003   -3.3000    0.0000 C   0  0
    6.4523   -1.9997    0.0000 C   0  0
    4.9523   -1.9974    0.0000 C   0  0
    3.9511   -0.8815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    4.2003   -3.2952    0.0000 C   0  0
    4.9482   -4.5954    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 F   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 11  1  0
 15 16  2  0
 16  8  1  0
 13 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 20  1  0
 26 27  1  0
 27 28  2  0
 28 17  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28719

> <plate>
Kinase v5-2

> <well>
P12

> <supplier_cmpd_name>
CHIR-258 (TKI258, Dovitinib)

> <ctcr_id>
4809

> <supplier_cmpd_id>
SY-CHIR-258

> <smiles>
CN1CCN(CC1)c2ccc3nc([nH]c3c2)c4c(N)c5c(F)cccc5nc4O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Dovitinib,405169-16-6,405169166,"405169 16 6",CHIR-258,CHIR258,"CHIR 258",TKI-258,TKI258,"TKI 258","Dovitinib (TKI-258, CHIR-258)","Dovitinib (TKI258, CHIR258)","Dovitinib (TKI 258, CHIR 258)","Chir 
258","Dovitinib free base",CHEMBL522892,UNII-I35H5,UNIII35H5,SY-CHIR-258,S1018,"CHIR-258 (TKI258, Dovitinib)","Dovitinib (TKI-258) Dilactic Acid"}

> <pdid>

> <targets>
{Flt,FGFR,Multi Kinase Inhibitors (c-Kit,VEGFR,c-Kit,FMS,FLT3,VEGFR),PDGFR}

> <classes>
{Angiogenesis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{135398510}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
    6.3028   -4.8211    0.0000 C   0  0
    4.8111   -4.6641    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 S   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.2948   -3.7517    0.0000 O   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    4.2567    0.5878    0.0000 C   0  0
    3.2235    1.6679    0.0000 C   0  0
    3.6446    3.1076    0.0000 C   0  0
    5.1019    3.4627    0.0000 C   0  0
    6.1382    2.3782    0.0000 C   0  0
    7.5955    2.7333    0.0000 C   0  0
    5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 10 20  2  0
 20  6  1  0
  5 21  2  0
 21 22  1  0
 22  3  2  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 27 29  2  0
 29 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28720

> <plate>
Kinase v5-2

> <well>
P14

> <supplier_cmpd_name>
TAK-715

> <ctcr_id>
4971

> <supplier_cmpd_id>
SY-TAK-715

> <smiles>
CCc1sc(c2ccnc(NC(=O)c3ccccc3)c2)c(n1)c4cccc(C)c4

> <pd_targets>
{MAPK9,MAPK11,SLK,MAPK14,KDR,CSNK1D,EGFR,PRKD3,CSNK1A1,MAP4K5,ALK,MAP4K4,CSNK1G3,MAP3K20,CSNK1G1,MAPK8,IKBKB,CSNK1G2,FRK,MINK1,PTK6,FLT4,ERBB4,PRKD2,MAPK12,MAPK13}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","STE protein kinase group","TK protein kinase group","CK1 protein kinase group","CAMK protein kinase group","TKL protein kinase group","Othe
r protein kinase group","CMGC protein kinase MAPK family","STE protein kinase STE20 family","Tyrosine protein kinase VEGFR family","CK1 protein kinase CK1 family","Tyrosine protein kinase EGFR family"
,"CAMK protein kinase PKD family","TKL protein kinase STKR family","TKL protein kinase MLK family","Other protein kinase IKK family","Tyrosine protein kinase Src family","CMGC protein kinase JNK subfa
mily","CMGC protein kinase p38 subfamily","STE protein kinase SLK subfamily","STE protein kinase KHS subfamily","TKL protein kinase STKR Type 1 subfamily","STE protein kinase MSN subfamily","CK1 prote
in kinase CK1-g","TKL protein kinase MLK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases",
"CK1: Casein kinase 1","CAMK: Calcium/calmodulin-dependent protein kinases","Mitogen-activated protein kinases (MAP kinases)","STE20 family","TK: Tyrosine kinase","Casein kinase 1 (CK1) family","Prote
in kinase D (PKD) family","TKL: Tyrosine kinase-like","Other protein kinases","JNK subfamily","p38 subfamily","SLK subfamily","Receptor tyrosine kinases (RTKs)","KHS subfamily","MSN subfamily","Mixed 
Lineage Kinase (MLK) family","IKK family","Non-receptor tyrosine kinases (nRTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type I RTKs: ErbB (epidermal growth factor)
 receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","MLK subfamily","Src family"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Cell Cycle",Metabolism,Disease,"Cellular responses to external stimuli","Neuronal System","Innate Immune System","Signaling by Receptor Tyrosine Kinases",Mitoti
c,"Signaling by GPCR","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second messengers","Cellular responses to stress","Intracellular signaling by second messen
gers","Transmission across Chemical Synapses","Toll-like Receptor Cascades","Signaling by VEGF","Mitotic G2-G2/M phases","GPCR downstream signalling","Sphingolipid metabolism","Signaling by WNT in can
cer","Cellular Senescence","PIP3 activates AKT signaling","Mitotic G1 phase and G1/S transition","Neurotransmitter receptors and postsynaptic signal transmission","Toll Like Receptor 5 (TLR5) Cascade"
,"VEGFA-VEGFR2 Pathway","G2/M Transition","G alpha (q) signalling events","Sphingolipid de novo biosynthesis","Signaling by AMER1 mutants","Oxidative Stress Induced Senescence","Toll Like Receptor 4 (
TLR4) Cascade","PTEN Regulation","G1 Phase","VEGF ligand-receptor interactions","Activation of NMDA receptors and postsynaptic events","MyD88 cascade initiated on plasma membrane","VEGFR2 mediated cel
l proliferation","Centrosome maturation","Gastrin-CREB signalling pathway via PKC and MAPK","Truncations of AMER1 destabilize the destruction complex","MyD88-independent TLR4 cascade","Regulation of P
TEN stability and activity","Cyclin D associated events in G1","VEGF binds to VEGFR leading to receptor dimerization","Post NMDA receptor activation events","MAP kinase activation","Loss of proteins r
equired for interphase microtubule organization from the centrosome","EGFR Transactivation by Gastrin","TRIF(TICAM1)-mediated TLR4 signaling","Long-term potentiation","MAPK targets/ Nuclear events med
iated by MAP kinases","Loss of Nlp from mitotic centrosomes","IKK complex recruitment mediated by RIP1","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{AK71,TAK-715,TAK715,303162-79-0,303162790,"TAK 715",N-(4-(2-ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide,N(4(2ethyl4(mtolyl)thiazol5yl)pyridin2yl)benzamide,UNII-WE92U03C5Z,UNIIWE92U03C5Z,"Ben
zamide, N-(4-(2-ethyl-4-(3-methylphenyl)-5-thiazolyl)-2-pyridinyl)-","Benzamide, N(4(2ethyl4(3methylphenyl)5thiazolyl)2pyridinyl)",N-(4-(2-ethyl-4-(3-methylphenyl)-1,N(4(2ethyl4(3methylphenyl)1,3-thia
zol-5-yl)pyridin-2,3thiazol5yl)pyridin2,T6150,SY-TAK-715,S2928}

> <pdid>
PD010510

> <targets>
{"p38 MAPK","Casein Kinase"}

> <classes>
{MAPK,Cell Cycle/DNA Damage,MAPK/ERK Pathway,Stem Cell/Wnt}

> <pubchem_cids>
{9952773}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Cl  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Cl  0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 C   0  0
   -1.2946   -3.7531    0.0000 O   0  0
    1.3039   -3.7494    0.0000 N   0  0
    1.3070   -5.2502    0.0000 C   0  0
    0.0935   -6.1101    0.0000 C   0  0
    0.5570   -7.5366    0.0000 N   0  0
    2.0570   -7.5366    0.0000 N   0  0
    2.5205   -6.1100    0.0000 C   0  0
    3.9428   -5.6391    0.0000 C   0  0
    4.2459   -4.1700    0.0000 O   0  0
    5.0644   -6.6363    0.0000 N   0  0
    6.4891   -6.1645    0.0000 C   0  0
    7.6116   -7.1595    0.0000 C   0  0
    9.0346   -6.6851    0.0000 C   0  0
    9.3352   -5.2155    0.0000 N   0  0
    8.2128   -4.2204    0.0000 C   0  0
    6.7898   -4.6948    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 12  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28721

> <plate>
Kinase v5-2

> <well>
P16

> <supplier_cmpd_name>
AT-7519

> <ctcr_id>
2199

> <supplier_cmpd_id>
SY-AT-7519

> <smiles>
Clc1cccc(Cl)c1C(=O)Nc2c[nH]nc2C(=O)NC3CCNCC3

> <pd_targets>
{TLK1,TAOK2,TAOK3,CLK2,DYRK1B,CDK2,CDK7,CDK9,CCNA1,CCNA2,DMPK,CDK17,DCLK3,CDK16,TAOK1,CDK5,SLK,CDK3,DYRK2,DCLK2,CCND1,CDK4,CDK5R1,CDK11B,DYRK1A,CAMKK2,CILK1,CLK4,MAK,CDK14,CDK19,CDK13,MAPK7,GSK3B,CDK1
1A,MAPK15,CLK1,CDK18,CASK,CLK3,CCNY,CDKL2,GSK3A,CDKL5,CCND3,CDK6,CDK15,CCNB1,CDK1,CCNE1,CCNH,MNAT1,CDK10,CDK12,CDK20,CDK8}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","STE protein kinase group","CMGC protein kinase group","AGC protein kinase group","CAMK protein kinase group","Other protein kinase TLK fam
ily","STE protein kinase STE20 family","CMGC protein kinase CLK family","CMGC protein kinase DYRK family","CMGC protein kinase CDK family","AGC protein kinase DMPK family","CAMK protein kinase DCAMK1 
family","Other protein kinase CAMKK family","CMGC protein kinase RCK family","CMGC protein kinase MAPK family","CMGC protein kinase GSK family","CMGC protein kinase CDKL family","STE protein kinase TA
O subfamily","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily","AGC protein kinase GEK subfamily","CM
GC protein kinase PCTAIRE","CMGC protein kinase TAIRE subfamily","CMGC protein kinase CDK5 subfamily","STE protein kinase SLK subfamily","CMGC protein kinase Dyrk2 subfamily","CMGC protein kinase PITS
LRE subfamily","Other protein kinase Meta subfamily","CMGC protein kinase MAK","CMGC protein kinase PFTAIRE","CMGC protein kinase CDK8 subfamily","CMGC protein kinase ERK5"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families",
"AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","STE20 family","CLK family","Dual-specificity tyrosine-(Y)-phosphorylation regulat
ed kinase (DYRK) family","Cyclin-dependent kinase (CDK) family","DMPK family","DCAMKL family","RCK family","Mitogen-activated protein kinases (MAP kinases)","Glycogen synthase kinase (GSK) family","CA
SK family","Cyclin-dependent kinase-like (CDKL) family","Tousled-like kinase (TLK) family","TAO subfamily","Dyrk1 subfamily","CDK1 subfamily","CDK7 subfamily","CDK9 subfamily","GEK subfamily","TAIRE s
ubfamily","CDK5 subfamily","SLK subfamily","Dyrk2 subfamily","PITSLRE subfamily","CDK4 subfamily","CAMKK family","CDK8 subfamily","CRK7 subfamily","ERK subfamily","GSK subfamily","Erk7 subfamily","Met
a subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,"Muscle contraction","Cell Cycle","Neuronal System",Metabolism,"Immune System","RNA Polymerase II Transcription","Infectious disease","Cardiac conduction",Mi
totic,"Transmission across Chemical Synapses","Metabolism of lipids","Innate Immune System","Generic Transcription Pathway","HIV Infection","Ion homeostasis","M Phase","Mitotic G2-G2/M phases","Mitoti
c G1 phase and G1/S transition","Neurotransmitter receptors and postsynaptic signal transmission","Regulation of lipid metabolism by PPARalpha","Toll-like Receptor Cascades","SARS-CoV Infections","Reg
ulation of mitotic cell cycle","Transcriptional Regulation by TP53","HIV Life Cycle","Mitotic Metaphase and Anaphase","G2/M Transition","G1 Phase","G0 and Early G1","Activation of NMDA receptors and p
ostsynaptic events","PPARA activates gene expression","Toll Like Receptor 5 (TLR5) Cascade","SARS-CoV-1 Infection","APC/C-mediated degradation of cell cycle proteins","Regulation of TP53 Activity","La
te Phase of HIV Life Cycle","Mitotic Anaphase","Centrosome maturation","Cyclin D associated events in G1","Post NMDA receptor activation events","TP53 Regulates Transcription of DNA Repair Genes","MyD
88 cascade initiated on plasma membrane","SARS-CoV-1 Genome Replication and Transcription","Assembly and cell surface presentation of NMDA receptors","Activation of APC/C and APC/C:Cdc20 mediated degr
adation of mitotic proteins","Regulation of TP53 Expression and Degradation","Transcription of the HIV genome","Separation of Sister Chromatids","Regulation of TP53 Activity through Phosphorylation","
Recruitment of mitotic centrosome proteins and complexes","Activation of AMPK downstream of NMDARs","MAP kinase activation","Replication of the SARS-CoV-1 genome","APC/C:Cdc20 mediated degradation of 
mitotic proteins","Regulation of TP53 Degradation","HIV Transcription Elongation","MAPK targets/ Nuclear events mediated by MAP kinases","APC:Cdc20 mediated degradation of cell cycle proteins prior to
 satisfation of the cell cycle checkpoint","Tat-mediated elongation of the HIV-1 transcript","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Formation of HIV-1 elongation co
mplex containing HIV-1 Tat","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{LZE,AT7519,844442-38-2,844442382,AT-7519,"AT 7519","4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide","4(2,6dichlorobenzamido)N(piperidin4yl)1Hpyrazole3carboxamide",UNII-X1BF92P
W9T,UNIIX1BF92PW9T,"N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide","N(4Piperidinyl)4(2,6dichlorobenzoylamino)1Hpyrazole3carboxamide","AT-7519 free base","AT7519 free base",X
1BF92PW9T,4-((2,4((2,6-dic,6dic,S1524,SY-AT-7519}

> <pdid>
PD004706

> <targets>
{CDK}

> <classes>
{"Cell Cycle"}

> <pubchem_cids>
{11338033}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    6.4994    0.7568    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    6.4995   -3.7432    0.0000 C   0  0
    7.7985   -2.9932    0.0000 C   0  0
    9.0976   -3.7432    0.0000 O   0  0
    7.7985   -1.4932    0.0000 N   0  0
    3.9008   -3.7437    0.0000 C   0  0
    2.6004   -2.9959    0.0000 C   0  0
    1.3026   -3.7480    0.0000 C   0  0
    1.3050   -5.2480    0.0000 C   0  0
    2.6053   -5.9959    0.0000 C   0  0
    3.9031   -5.2438    0.0000 C   0  0
    0.0065   -6.0005    0.0000 C   0  0
   -1.2942   -5.2534    0.0000 F   0  0
    0.0094   -7.5005    0.0000 F   0  0
   -1.2910   -6.7532    0.0000 F   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 O   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 F   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  2  1  0
  4  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 12 15  1  0
 15 16  1  0
 15 17  1  0
 15 18  1  0
  3 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 24  2  0
 28 29  1  0
 29 30  2  0
 30 22  1  0
 30 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28722

> <plate>
Kinase v5-2

> <well>
P18

> <supplier_cmpd_name>
RHO-15   (GSK429286A)

> <ctcr_id>
3127

> <supplier_cmpd_id>
SY-RHO-15

> <smiles>
CC1=C(C(CC(=O)N1)c2ccc(cc2)C(F)(F)F)C(=O)Nc3cc4cn[nH]c4cc3F

> <pd_targets>
{RPS6KA1,ROCK1,RPS6KB1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase RSK family","AGC protein kinase DMPK family","AGC protein kinase RSK subfamily","AGC protein kinase ROCK subfamily","AGC 
protein kinase p70 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","RSK family","DMPK family","RSK subfamily","Rho kinase","p70 subfamily"}

> <pathway_reactome>
{"Immune System","Developmental Biology","Signal Transduction","Innate Immune System","Nervous system development","MTOR signalling","Toll-like Receptor Cascades","Axon guidance","mTORC1-mediated sign
alling","Toll Like Receptor 5 (TLR5) Cascade","Semaphorin interactions","MyD88 cascade initiated on plasma membrane","Sema4D in semaphorin signaling","MAP kinase activation","Sema4D induced cell migra
tion and growth-cone collapse","MAPK targets/ Nuclear events mediated by MAP kinases","CREB phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{AS-16226,AS16226,HY-11000,HY11000,FT-0735355,FT0735355,GSK429286A,864082-47-3,864082473,RHO-15,RHO15,"GSK 429286",C21H16F4N4O2,cc-634,cc634,CHEMBL375312,GTPL9356,SCHEMBL2801740,BDBM14055,CHEBI:91332,
"dihydropyridone indazole amide 15",DTXSID70463946,SYN1071,BCPP000217,HMS3244C07,HMS3244C08,H,T2633,SY-RHO-15,S1474,"RHO-15   (GSK429286A)"}

> <pdid>
PD011177

> <targets>
{ROCK1,ROCK}

> <classes>
{Cell Cycle,Cell Cycle/DNA Damage,Cytoskeleton,Stem Cell/Wnt,TGF-beta/Smad}

> <pubchem_cids>
{11373846}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 37  0  0  0  0            999 V2000
    4.1820    5.0721    0.0000 C   0  0
    3.7973    3.6223    0.0000 N   0  0
    4.7439    2.4588    0.0000 C   0  0
    3.9173    1.2212    0.0000 C   0  0
    2.4810    1.5838    0.0000 C   0  0
    1.2248    0.7640    0.0000 C   0  0
   -0.1132    1.4419    0.0000 C   0  0
   -0.1952    2.9396    0.0000 C   0  0
    1.0609    3.7595    0.0000 C   0  0
    2.3990    3.0816    0.0000 C   0  0
    4.5721   -0.1292    0.0000 C   0  0
    6.0299   -0.3989    0.0000 C   0  0
    6.2649   -1.8685    0.0000 C   0  0
    7.5973   -2.5575    0.0000 O   0  0
    4.9193   -2.5313    0.0000 N   0  0
    3.8731   -1.4563    0.0000 C   0  0
    2.3885   -1.6709    0.0000 O   0  0
    7.1840    0.5604    0.0000 C   0  0
    7.0865    2.0564    0.0000 C   0  0
    5.9087    2.9853    0.0000 C   0  0
    6.1243    4.4697    0.0000 C   0  0
    4.9478    5.4015    0.0000 C   0  0
    5.1654    6.8857    0.0000 N   0  0
    7.5176    5.0252    0.0000 C   0  0
    8.6954    4.0964    0.0000 C   0  0
    8.4798    2.6119    0.0000 N   0  0
    9.4384    1.4592    0.0000 C   0  0
   10.9362    1.4007    0.0000 C   0  0
   11.6344    0.0731    0.0000 C   0  0
   10.8337   -1.1953    0.0000 C   0  0
    9.3348   -1.1361    0.0000 C   0  0
    8.6378    0.1908    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10  5  1  0
  4 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 12 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 21 24  1  0
 24 25  1  0
 25 26  1  0
 26 19  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 18  1  0
 32 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28723

> <plate>
Kinase v5-2

> <well>
P20

> <supplier_cmpd_name>
Ro-31-8425

> <ctcr_id>
3678

> <supplier_cmpd_id>
SY-Ro-31-8425

> <smiles>
Cn1cc(c2ccccc12)C3=C(C(=O)NC3=O)c4c5CC(CN)CCn5c6ccccc46

> <pd_targets>
{MYLK,PRKCA,PRKCB,PRKCG,PRKCD,PRKCE,PRKCH,PRKCQ,PRKD1,PRKD3,PRKACA,PRKACB,PRKACG,PRKCZ}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","AGC protein kinase group","CAMK protein kinase MLCK family","AGC protein kinase PKC family","AGC protein kinase PKA family","AGC protein ki
nase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","Myosin Light Chain Kinase (MLCK) family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Rho GTPases","RHO GTPase Effectors","RHO GTPases activate PAKs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{O31842,131848-97-0,131848970,Ro-31-8425,Ro318425,"Ro 31-8425","Ro 318425",Ro31.8425,ACMC-20ckvd,ACMC20ckvd,BDBM2700,CHEMBL421565,SCHEMBL4360666,DTXSID60927365,BCP27621,HSCI1_000343,HSCI1000343,HSCI1-
000343,"HSCI1 000343",NSC767242,"BIM 10; Bisindolylmaleimide X, HCl",ES-0009,ES0009,NSC-767242,NCGC00262061-02,NCGC0026206102,K00205,"Ro-31-8425 - CAS 13184","Ro318425  CAS 13184",SY-Ro-31-8425}

> <pdid>
PD045241

> <targets>
{PKC}

> <classes>
{}

> <pubchem_cids>
{2404}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    7.6994    4.5206    0.0000 C   0  0
    6.1994    4.5163    0.0000 N   0  0
    5.3212    3.3003    0.0000 N   0  0
    3.8941    3.7597    0.0000 C   0  0
    2.5972    3.0060    0.0000 C   0  0
    1.2961    3.7523    0.0000 C   0  0
    1.2918    5.2523    0.0000 C   0  0
    2.5887    6.0060    0.0000 C   0  0
    3.8898    5.2597    0.0000 C   0  0
    5.3143    5.7273    0.0000 C   0  0
    5.7736    7.1552    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -0.0014    1.5008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 N   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -5.1977    2.9828    0.0000 N   0  0
   -5.1903    1.4820    0.0000 C   0  0
   -6.4841    0.7230    0.0000 C   0  0
   -6.4738   -0.7770    0.0000 C   0  0
   -5.1696   -1.5180    0.0000 C   0  0
   -5.1592   -3.0180    0.0000 C   0  0
   -3.8757   -0.7590    0.0000 C   0  0
   -3.8861    0.7409    0.0000 C   0  0
   -2.5708   -1.5004    0.0000 S   0  0
   -1.2773   -0.7410    0.0000 N   0  0
   -2.5595   -3.0004    0.0000 O   0  0
   -1.2663   -2.2408    0.0000 O   0  0
   -2.6005    2.9949    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9  4  1  0
  9 10  2  0
 10  2  1  0
 10 11  1  0
  6 12  1  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 20  1  0
 25 27  1  0
 27 28  1  0
 27 29  2  0
 27 30  2  0
 18 31  2  0
 31 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28724

> <plate>
Kinase v5-2

> <well>
P22

> <supplier_cmpd_name>
Pazopanib (GW786034, Votrient)

> <ctcr_id>
2306

> <supplier_cmpd_id>
SY-Pazopanib

> <smiles>
Cn1nc2cc(ccc2c1C)N(C)c3ccnc(Nc4ccc(C)c(c4)[S](N)(=O)=O)n3

> <pd_targets>
{RET,ABL1,ABL2,JAK3,MAPK10,DDR2,LCK,EIF2AK2,PTK6,RAF1,MAP4K2,FGR,FYN,MYLK2,ROS1,STK36,PLK4,MAP2K4,EPHB6,FGFR3,MAP3K11,TXK,LIMK1,MAP3K10,CAMK1G,LIMK2,STK10,KIT,FLT4,FGFR1,FLT1,CDK16,PDGFRB,FRK,TNIK,MAP
K8,NEK2,DDR1,TGFBR2,KDR,MAP4K1,MAP4K3,BMP2K,MAP2K6,CDK11A,MAP3K9,LYN,FLT3,PI4KB,RIPK1,BLK,AURKC,SIK1,TIE1,ACHE,IGF1R,JAK2,GAK,RIOK2,ALK,FER,FGFR2,RIPK2,BRAF,CAMK1,NLK,TTK,PDGFRA,AAK1,ACVR2B,FGFR4,YES1
,MAP3K2,SYK,PTK2,EGFR,CSF1R,CDPK1,MERTK,STK16,MAP4K4,MAP4K5,CDK11B,PIP5K1C,PIP4K2C,MAP3K19,IRAK3,MET,BMPR1B,CDK7,TNK1,TAOK3,TAOK2,MAPK9,FES,HCK,TAOK1,LTK,IRAK1,TYK2,AURKA,TEK,MARK3,AURKB,MAP3K1,MAP2K5
,SRC,SRMS,SIK2,SLK,TNK2,NEK5,ABCB11,ABCC4,ITK,FGF1,SH2B3}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein",Transporter,"Secreted protein",Kinase,Transferase,Hydrolase,"Primary active transporter","Protein Kinase","ATP-binding cassette","TK protein kinase group","CMGC protein 
kinase group","Other protein kinase group","TKL protein kinase group","STE protein kinase group","CAMK protein kinase group","Atypical protein kinase group","ABCB subfamily","ABCC subfamily","Tyrosine
 protein kinase Ret family","Tyrosine protein kinase Abl family","Tyrosine protein kinase JakA family","CMGC protein kinase MAPK family","Tyrosine protein kinase DDR family","Tyrosine protein kinase S
rc family","Other protein kinase PEK family","TKL protein kinase RAF family","STE protein kinase STE20 family","CAMK protein kinase MLCK family","Tyrosine protein kinase Sev family","Other protein kin
ase ULK family","Other protein kinase PLK family","STE protein kinase STE7 family","Tyrosine protein kinase FGFR family","TKL protein kinase MLK family","Tyrosine protein kinase Tec family","TKL prote
in kinase LISK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","CMGC protein kinase CDK family","Other protein kinase NEK famil
y","TKL protein kinase STKR family","Other protein kinase NAK family","TKL protein kinase RIPK family","Other protein kinase AUR family","Tyrosine protein kinase Tie family","Tyrosine protein kinase I
nsR family","Atypical protein kinase RIO family","Tyrosine protein kinase Fer family","Other protein kinase TTK family","STE protein kinase STE11 family","Tyrosine protein kinase Syk family","Tyrosine
 protein kinase Fak family","Tyrosine protein kinase Axl family","TKL protein kinase IRAK family","Tyrosine protein kinase Met family","Tyrosine protein kinase Ack family","Tyrosine protein kinase Alk
 family","CMGC protein kinase JNK subfamily","Other protein kinase PKR","STE protein kinase KHS subfamily","Tyrosine protein kinase SrcA","TKL protein kinase MLK subfamily","TKL protein kinase LIMK su
bfamily","STE protein kinase SLK subfamily","CMGC protein kinase TAIRE subfamily","STE protein kinase MSN subfamily","TKL protein kinase STKR Type 2 subfamily","CMGC protein kinase PITSLRE subfamily",
"CAMK protein kinase QIK subfamily","Atypical protein kinase RIO2 subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase nmo subfamily","STE protein kinase MEKK2","CMGC protein kin
ase CDK7 subfamily","STE protein kinase TAO subfamily","CAMK protein kinase MARK subfamily","Tyrosine protein kinase Srm"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"Catalytic receptors","Kinases (EC 2.7.x.x)","Acetylcholine turnover","ATP-binding cassette transporter family","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK
 families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Lipid modifying kinases",Atypical,"ABCB subfamily","ABCC subfamily
","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Other protein kinases","TKL: Tyrosine kinase-like","STE20 family","Myosin Light Chain Kinase (MLCK) family","STE7 family","CA
MK1 family","Cyclin-dependent kinase (CDK) family","1-phosphatidylinositol 4-kinase family","CAMK-like (CAMKL) family","RIO family","STE11 family","Type I PIP kinases (1-phosphatidylinositol-4-phospha
te 5-kinase family)","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","JNK subfamily","PEK family",
"RAF family","KHS subfamily","Unc-51-like kinase (ULK) family","Polo-like kinase (PLK) family","Mixed Lineage Kinase (MLK) family","LIM domain kinase (LISK) family","SLK subfamily","TAIRE subfamily","
MSN subfamily","NIMA (never in mitosis gene a)- related kinase (NEK) family","Receptor serine/threonine kinase (RSTK) family","Numb-associated kinase (NAK) family","PITSLRE subfamily","Receptor intera
cting protein kinase (RIPK) family","Aurora kinase (Aur) family","QIK subfamily","RIO2 subfamily","nmo subfamily","TTK family","NAK family","STE20 subfamily","Interleukin-1 receptor-associated kinase 
(IRAK) family","CDK7 subfamily","TAO subfamily","MARK subfamily","Type XIV RTKs: RET","Abl family","Janus kinase (JakA) family","Type XVI RTKs: DDR (collagen receptor) family","Src family","Other PEK 
family kinases","Type XVII RTKs: ROS receptors","Type XIII RTKs: Ephrin receptor family","Type V RTKs: FGF (fibroblast growth factor) receptor family","MLK subfamily","Tec family","LIMK subfamily","Ty
pe III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type II receptor serine/threonine kinases","Type XII RTKs: TIE family of 
angiopoietin receptors","Type II RTKs: Insulin receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Fer family","Syk family","Fak family","Type XI RTKs: TAM (TYRO3-","AXL
- and MER-TK) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type I receptor serine/threonine kinases","Ack family"}

> <pathway_reactome>
{"Developmental Biology",Disease,"Immune System","Extracellular matrix organization","Cell Cycle","Signal Transduction","Cellular responses to external stimuli","Gene expression (Transcription)",Metab
olism,"Circadian Clock","Vesicle-mediated transport","Metabolism of RNA","Neuronal System",Hemostasis,"Nervous system development","Infectious disease","Cytokine Signaling in Immune system","Innate Im
mune System","Non-integrin membrane-ECM interactions",Mitotic,"MAPK family signaling cascades","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor
 Tyrosine Kinases","Intracellular signaling by second messengers","Cellular responses to stress","RNA Polymerase II Transcription","Metabolism of lipids","Membrane Trafficking","rRNA processing","Tran
smission across Chemical Synapses","Signaling by WNT","Signaling by NODAL","Cell surface interactions at the vascular wall","Signaling by TGFB family members","Signaling by Non-Receptor Tyrosine Kinas
es","Platelet activation","signaling and aggregation","Adaptive Immune System","Axon guidance","Leishmania infection","Signaling by Interleukins","Toll-like Receptor Cascades","HIV Infection","Influen
za Infection","Mitotic G1 phase and G1/S transition","MAPK1/MAPK3 signaling","Mitotic G2-G2/M phases","Signaling by FGFR in disease","Oncogenic MAPK signaling","Fc epsilon receptor (FCERI) signaling",
"Neutrophil degranulation","Signaling by KIT in disease","Signaling by VEGF","PIP3 activates AKT signaling","Cellular Senescence","Regulation of mitotic cell cycle","Signaling by TGF-beta Receptor Com
plex in Cancer","Generic Transcription Pathway","Signaling by Insulin receptor","Phospholipid metabolism","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","trans-Golgi Network Vesic
le Budding","rRNA processing in the nucleus and cytosol","Signaling by SCF-KIT","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Beta-catenin independent WNT sig
naling","Signaling by PDGFR in disease","Clathrin-mediated endocytosis","Regulation of signaling by NODAL","Signaling by FGFR","Signaling by BMP","M Phase","Interferon Signaling","Signaling by PTK6","
Metabolism of steroids","Response to elevated platelet cytosolic Ca2+","TCR signaling","FLT3 Signaling","RET signaling","Parasite infection","Signaling by ROBO receptors","Interleukin-2 family signali
ng","Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","NS1 Mediated Effects on Host Pathways","G1 Phase","RAF/MAP kinase cascade","Leishmania parasite growth and survival","G2/M
 Transition","EPH-Ephrin signaling","Signaling by FGFR3 in disease","Signaling by RAS mutants","FCERI mediated Ca+2 mobilization","Semaphorin interactions","Drug resistance of KIT mutants","VEGF ligan
d-receptor interactions","Signaling by FGFR1 in disease","Negative regulation of the PI3K/AKT network","PTEN Regulation","Oxidative Stress Induced Senescence","APC/C-mediated degradation of cell cycle
 proteins","Loss of Function of SMAD2/3 in Cancer","VEGFA-VEGFR2 Pathway","Transcriptional Regulation by TP53","Insulin receptor signalling cascade","PI Metabolism","Toll Like Receptor 4 (TLR4) Cascad
e","Transcriptional regulation by RUNX1","Glycerophospholipid biosynthesis","IGF1R signaling cascade","Golgi Associated Vesicle Biogenesis","Major pathway of rRNA processing in the nucleolus and cytos
ol","Signaling by FGFR2 in disease","Signaling by NTRK1 (TRKA)","Activation of NMDA receptors and postsynaptic events","Ca2+ pathway","Drug resistance of PDGFR mutants","Cargo recognition for clathrin
-mediated endocytosis","Signaling by FGFR4","Transcriptional Regulation by VENTX","Toll Like Receptor 2 (TLR2) Cascade","HIV Life Cycle","Mitotic Metaphase and Anaphase","Interferon alpha/beta signali
ng","PTK6 Down-Regulation","Bile acid and bile salt metabolism","Platelet degranulation","Generation of second messenger molecules","Negative regulation of FLT3","Leishmania phagocytosis","Role of ABL
 in ROBO-SLIT signaling","Interleukin-15 signaling","MyD88 cascade initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Inhibition of PKR","Cyclin D associate
d events in G1","Negative regulation of MAPK pathway","Anti-inflammatory response favouring Leishmania parasite infection","Centrosome maturation","EPHB-mediated forward signaling","Signaling by FGFR3
 point mutants in cancer","Signaling downstream of RAS mutants","Sema4D in semaphorin signaling","Dasatinib-resistant KIT mutants","VEGF binds to VEGFR leading to receptor dimerization","FGFR1 mutant 
receptor activation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Regulation of PTEN stability and activity","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","SMAD2/
3 Phosphorylation Motif Mutants in Cancer","VEGFR2 mediated cell proliferation","Regulation of TP53 Activity","IRS-mediated signalling","Synthesis of PIPs at the Golgi membrane","MyD88-independent TLR
4 cascade","RUNX1 regulates transcription of genes involved in BCR signaling","Synthesis of PC","IRS-related events triggered by IGF1R","FGFR2 mutant receptor activation","Signalling to ERKs","Post NM
DA receptor activation events","Imatinib-resistant PDGFR mutants","Downstream signaling of activated FGFR4","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","Toll Like Receptor TLR6
:TLR2 Cascade","Late Phase of HIV Life Cycle","CRMPs in Sema3A signaling","Mitotic Anaphase","Regulation of IFNA signaling","Signalling to ERK5","Synthesis of bile acids and bile salts","FCGR3A-mediat
ed phagocytosis","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Negative feedback regulation of MAPK pathway","FCGR3A-mediate
d IL10 synthesis","Nef and signal transduction","Loss of proteins required for interphase microtubule organization from the centrosome","FGFR3 mutant receptor activation","Sema4D induced cell migratio
n and growth-cone collapse","Signaling by activated point mutants of FGFR1","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity through Acetylation","Recruitment of mit
otic centrosome proteins and complexes","PI3K Cascade","TRIF(TICAM1)-mediated TLR4 signaling","Activated point mutants of FGFR2","Prolonged ERK activation events","Activation of RAC1 downstream of NMD
ARs","FRS-mediated FGFR4 signaling","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Sema4D mediated inhibition of cell attachment and migration","Transcription of the HIV genome","Separation 
of Sister Chromatids","Regulation of TP53 Activity through Phosphorylation","Signalling to RAS","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol","MAPK targets/ Nuclear events med
iated by MAP kinases","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","Signaling by act
ivated point mutants of FGFR3","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","PI5P Regulates TP53 Acetylation","IKK complex recruitment medi
ated by RIP1","activated TAK1 mediates p38 MAPK activation","ARMS-mediated activation","HIV Transcription Elongation","p38MAPK events","Activation of the AP-1 family of transcription factors","APC-Cdc
20 mediated degradation of Nek2A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{CSF1R,FGF1,FGFR1,FGFR3,FLT1,FLT4,ITK,KDR,KIT,PDGFRA,PDGFRB,SH2B3}

> <broad_moa>
{"KIT inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{Pazopanib,444731-52-6,444731526,GW786034,UNII-7RN5DR86CK,UNII7RN5DR86CK,"Pazopanib (GW-786034)","Pazopanib (GW786034)","GW 786034",790713-33-6,790713336,7RN5DR86CK,"GW 78603",CHEBI:71219,MFCD11616589
,NCGC00188865-01,NCGC0018886501,DSSTox_CID_28659,DSSToxCID28659,DSSTox-CID-28659,"DSSTox CID 28659",DSSTox_RID_82929,DSSToxRID82929,DSSTox-RID-82929,"DSSTox RID 82929",DSSTox_GSID_48733,DSSToxGSID4873
3,DSSTox-GSID-48733,"DSSTox GSID 48733",GW-786034,C21H23N7O2S,CAS-444731-52,CAS44473152,T0097L,SY-Pazopanib,"Pazopanib (GW786034, Votrient)",PAZOPANIB}

> <pdid>
PD003339

> <targets>
{VEGFR,"VEGFR KIT PDGFR"}

> <classes>
{}

> <pubchem_cids>
{10113978}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 34  0  0  0  0            999 V2000
   10.1964   -3.3806    0.0000 Cl  0  0
    7.6964   -3.3806    0.0000 Cl  0  0
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    1.2997   -3.7504    0.0000 C   0  0
    1.3022   -5.2504    0.0000 C   0  0
    2.6024   -5.9984    0.0000 C   0  0
    3.9003   -5.2463    0.0000 C   0  0
    3.8979   -3.7463    0.0000 C   0  0
    5.1957   -2.9942    0.0000 Br  0  0
    2.5976   -2.9984    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.8977   -3.7504    0.0000 C   0  0
   -5.1981   -3.0025    0.0000 C   0  0
   -6.4959   -3.7546    0.0000 C   0  0
   -6.4935   -5.2546    0.0000 C   0  0
   -5.1933   -6.0025    0.0000 N   0  0
   -3.8955   -5.2505    0.0000 C   0  0
   -7.7920   -6.0070    0.0000 N   0  0
   -9.0935   -5.2612    0.0000 C   0  0
  -10.3902   -6.0154    0.0000 C   0  0
  -10.3854   -7.5153    0.0000 O   0  0
   -9.0840   -8.2612    0.0000 C   0  0
   -7.7874   -7.5071    0.0000 C   0  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 19 13  1  0
 12 20  2  0
 20  4  1  0
 20  8  1  0
 10 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 24 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28725

> <plate>
Kinase v5-3

> <well>
J04

> <supplier_cmpd_name>
116890

> <ctcr_id>
998

> <supplier_cmpd_id>
EMD 116890

> <smiles>
Cl.Cl.Nc1ncnc2nc(cc(c3cccc(Br)c3)c12)c4ccc(nc4)N5CCOCC5

> <pd_targets>
{ADK,OPRD1,CHRM1,TACR2,OPRK1,SLC6A3}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor",Transporter,Transferase,"Family A G protein-coupled receptor","Electrochemical transporter","Peptide receptor (family A GPCR)","Small molecule receptor (family A GPCR)","SL
C superfamily of solute carriers","Short peptide receptor (family A GPCR)","Monoamine receptor","SLC06 neurotransmitter transporter family","Opioid receptor","Acetylcholine receptor","Neurokinin recep
tor"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Adenosine turnover","G protein-coupled receptors","SLC superfamily of solute carriers","Opioid receptors","Acetylcholine receptors (muscarinic)","Tachykinin receptors"
,"SLC6 neurotransmitter transporter family","Monoamine transporter subfamily"}

> <pathway_reactome>
{Metabolism,"Signal Transduction","Gene expression (Transcription)",Disease,"Metabolism of nucleotides","Signaling by GPCR","RNA Polymerase II Transcription","Disorders of transmembrane transporters",
"Nucleotide salvage","GPCR ligand binding","Generic Transcription Pathway","SLC transporter disorders","Purine salvage","Class A/1 (Rhodopsin-like receptors)","Transcriptional Regulation by MECP2","De
fective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)","Peptide ligand-binding receptors","Amine ligand-binding receptors","MECP2 regulates neuronal receptors and channels","Muscarinic acetylc
holine receptors","Tachykinin receptors bind tachykinins"}

> <broad_targets>
{ADK}

> <broad_moa>
{"adenosine kinase inhibitor"}

> <synonyms>
{"ABT 702 dihydrochloride","Adenosine Kinase Inhibitor","ABT-702 dihydrochloride","ABT702 dihydrochloride",1188890-28-9,1188890289,214697-26-4,214697264,"ABT702 2HCl","ABT-702 HCl","ABT702 HCl","ABT-7
02 2HCl","1188890-28-9 (HCl)","1188890289 (HCl)",DTXSID901017168,HMS3229B01,BCP20900,BCP26047,EX-A2617,EXA2617,T4668,"EMD 116890",116890}

> <pdid>
PD016398

> <targets>
{"Adenosine Kinase Inhibitor","Adenosine Kinase"}

> <classes>
{Metabolic Enzyme/Protease,Neuronal Signaling}

> <pubchem_cids>
{16760265}

$$$$
UTKinase_V5
  SciTegic11012413002D

 13 14  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 Br  0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 Br  0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 Br  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Br  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11  7  1  0
 11 12  2  0
 12  2  1  0
 12 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28726

> <plate>
Kinase v5-3

> <well>
L04

> <supplier_cmpd_name>
218697

> <ctcr_id>
1346

> <supplier_cmpd_id>
EMD 218697

> <smiles>
Brc1c(Br)c(Br)c2nn[nH]c2c1Br

> <pd_targets>
{CSNK2A1,CSNK2A2,CSNK2B,FTL,LMNA,KDM4E,ALOX15,HPGD,CYP3A4,DYRK1A,NQO2,REP,KMT2A,MEN1,THPO,NS3,GMNN,RECQL,NFKB1,ALDH1A1,BLM,CSNK2A3,MAPT,HSD17B10}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Other nuclear protein","Epigenetic regulator","Other cytosolic protein",Kinase,Eraser,Oxidoreductase,"Cytochrome P450",Transferase,Reader,Protease,"Protein Kinase","Lys
ine demethylase","Cytochrome P450 family 3",Bromodomain,"Serine protease","Other protein kinase group","Jumonji domain-containing","Cytochrome P450 family 3A","CMGC protein kinase group","Serine prote
ase PA clan","Other protein kinase CK2 family","Cytochrome P450 3A4","CMGC protein kinase DYRK family","Serine protease S29 family","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","Anti-infective targets","Receptor kinases
","1.14.11.- Histone demethylases",Lipoxygenases,"Prostaglandin synthases","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Viral protein targets","Other protein kinases","Dual-specifici
ty tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Coronavirus (CoV) proteins","Casein kinase 2 (CK2) family","Dyrk1 subfamily"}

> <pathway_reactome>
{"Vesicle-mediated transport","Gene expression (Transcription)","Cell Cycle",Metabolism,Disease,Hemostasis,"Immune System","DNA Repair","Neuronal System","Membrane Trafficking","RNA Polymerase II Tran
scription",Mitotic,"Metabolism of lipids","Biological oxidations","Infectious disease","Platelet activation","signaling and aggregation","Cytokine Signaling in Immune system","DNA Double-Strand Break 
Repair","Transmission across Chemical Synapses","Metabolism of amino acids and derivatives","trans-Golgi Network Vesicle Budding","Generic Transcription Pathway","M Phase","Biosynthesis of specialized
 proresolving mediators (SPMs)","Mitotic G1 phase and G1/S transition","Phase I - Functionalization of compounds","SARS-CoV Infections","Platelet Aggregation (Plug Formation)","Signaling by Interleuki
ns","Homology Directed Repair","Neurotransmitter receptors and postsynaptic signal transmission","Branched-chain amino acid catabolism","Golgi Associated Vesicle Biogenesis","Transcriptional Regulatio
n by TP53","Mitotic Metaphase and Anaphase","Biosynthesis of DPA-derived SPMs","Biosynthesis of DHA-derived SPMs","G0 and Early G1","SARS-CoV-2 Infection","G1/S Transition","Interleukin-1 family signa
ling","Ethanol oxidation","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Activation of NMDA receptors and postsynaptic events","Regulation of TP53 Activity","Mitotic An
aphase","Biosynthesis of DPAn-3 SPMs","Biosynthesis of D-series resolvins","Biosynthesis of maresins","SARS-CoV-2 Genome Replication and Transcription","Activation of the pre-replicative complex","Int
erleukin-1 signaling","HDR through Homologous Recombination (HRR)","Post NMDA receptor activation events","Regulation of TP53 Activity through Phosphorylation","Nuclear Envelope (NE) Reassembly","Bios
ynthesis of DPAn-3-derived protectins and resolvins","Biosynthesis of maresin-like SPMs","Replication of the SARS-CoV-2 genome","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Homologous DNA Pairing and
 Strand Exchange","Activation of AMPK downstream of NMDARs","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{17374-26-4,17374264,"4,5,6,7-tetrabromobenzotriazole","4,5,6,7tetrabromobenzotriazole",TBB,"4,5,6,7-Tetrabromo-1H-benzotriazole","4,5,6,7Tetrabromo1Hbenzotriazole",TBBt,"4,5,6,7-tetrabromo-2H-benzotr
iazole","4,5,6,7tetrabromo2Hbenzotriazole","4,5,6,7-Tetrabromo-1H-benzo(d)(1,2,3)triazole","4,5,6,7Tetrabromo1Hbenzo(d)(1,2,3)triazole",TETRABROMO-2-BENZOTRIAZOLE,TETRABROMO2BENZOTRIAZOLE,"4,5,6,7-Tet
rabromo-2-azabenzimidazole","4,5,6,7Tetrabromo2azabenzimidazole",Ca,2275,"EMD 218697",218697}

> <pdid>
PD002647

> <targets>
{"Casein Kinase II Inhibitor I",CK2}

> <classes>
{}

> <pubchem_cids>
{1694}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 30  0  0  0  0            999 V2000
    8.5188  -12.2439    0.0000 I   0  5
    5.4020  -25.9871    0.0000 C   0  0
    6.0188  -24.6197    0.0000 C   0  0
    5.1434  -23.4007    0.0000 C   0  0
    5.7605  -22.0326    0.0000 C   0  0
    4.8851  -20.8136    0.0000 C   0  0
    5.5023  -19.4455    0.0000 C   0  0
    4.6269  -18.2264    0.0000 C   0  0
    5.2441  -16.8584    0.0000 C   0  0
    4.3686  -15.6393    0.0000 C   0  0
    4.9858  -14.2713    0.0000 C   0  0
    4.1104  -13.0522    0.0000 C   0  0
    4.7276  -11.6841    0.0000 C   0  0
    3.8522  -10.4651    0.0000 C   0  0
    4.4693   -9.0970    0.0000 C   0  0
    3.5939   -7.8779    0.0000 C   0  0
    4.2111   -6.5099    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    1.8372   -5.2877    0.0000 C   0  0
    1.3786   -3.8595    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  3
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8056   -3.8679    0.0000 C   0  0
    5.2311   -3.4009    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 21 29  2  0
 29 18  1  0
 29 30  1  0
M  CHG  2   1  -1  21   1
M  END
> <name>
UTKinase_V5

> <id>
28727

> <plate>
Kinase v5-3

> <well>
N04

> <supplier_cmpd_name>
324515

> <ctcr_id>
1996

> <supplier_cmpd_id>
EMD 324515

> <smiles>
[I-].CCCCCCCCCCCCCCCCn1cc[n+](Cc2ccccc2)c1C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NH125,278603-08-0,278603080,"eEF-2 Kinase Inhibitor, NH125","eEF2 Kinase Inhibitor, NH125","1-Benzyl-3-cetyl-2-methylimidazolium iodide","1Benzyl3cetyl2methylimidazolium iodide","NH 125",nh-125,nh125
,"1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide","1Hexadecyl2methyl3(phenylmethyl)1Himidazolium iodide",MFCD07370143,"3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide","3Benzyl1hex
adecyl2methyl1Himidazol3ium iodide",CH,"EMD 324515",3439,324515}

> <pdid>

> <targets>
{"eEF-2 Kinase Inhibitor",NH125,"CaM Kinase III"}

> <classes>
{}

> <pubchem_cids>
{10436839}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 19  0  0  0  0            999 V2000
    6.1718    0.7439    0.0000 N   0  0
    7.0537   -0.4695    0.0000 C   0  0
    8.5454   -0.3119    0.0000 O   0  0
    6.4430   -1.8405    0.0000 N   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 S   0  0
    4.2010   -3.2956    0.0000 C   0  0
    4.8054   -4.6666    0.0000 C   0  0
    6.2966   -4.8284    0.0000 N   0  0
    3.9200   -5.8774    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9  5  2  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
  7 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
28728

> <plate>
Kinase v5-3

> <well>
P04

> <supplier_cmpd_name>
401490

> <ctcr_id>
4357

> <supplier_cmpd_id>
EMD 401490

> <smiles>
NC(=O)Nc1cc(sc1C(N)=O)c2ccccc2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{3-(Carbamoylamino)-5-Phenylthiophene-2-Carboxamide,3(Carbamoylamino)5Phenylthiophene2Carboxamide,CHEMBL1831214,SCHEMBL1382301,HMS3229H01,BDBM50353366,Q27458786,3-((Aminocarbonyl)amino)-5-phenyl-2-thi
ophenecarboxamide,3((Aminocarbonyl)amino)5phenyl2thiophenecarboxamide,"EMD 401490",401490}

> <pdid>

> <targets>
{"IKK-2 Inhibitor XI"}

> <classes>
{}

> <pubchem_cids>
{10220851}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 19  0  0  1  0            999 V2000
    8.8990    0.3702    0.0000 Cl  0  0
    6.3990    0.3702    0.0000 Cl  0  0
    2.5953   -3.0022    0.0000 C   0  0
    2.5978   -1.5022    0.0000 C   0  0  2  0  0  0
    3.8983   -0.7547    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0  2  0  0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0  2  0  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -7.7985    2.9932    0.0000 N   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
  4  3  1  1
  4  5  1  0
  4  6  1  0
  6  7  1  1
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11  6  1  0
  9 12  1  6
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28729

> <plate>
Kinase v5-3

> <well>
B06

> <supplier_cmpd_name>
Y-27632 2HCl

> <ctcr_id>
7714

> <supplier_cmpd_id>
S1049

> <smiles>
Cl.Cl.C[C@H](N)[C@@H]1CC[C@H](CC1)C(=O)Nc2ccncc2

> <pd_targets>
{PKN2,ROCK1,ROCK2,KCNH2,PRKCE,LMNA,CYP3A4,ALOX15,RPS6KA5,CCL2,PRKCQ,CDK5,CDK8,PRKD3,LTK,STK3,CLK4,CDC42BPA,PRKCD,CDK2,BRSK1,PRKG2,PRKX,LRRK2,CHUK,CDK1}

> <pathway_gtopdb>
{Enzyme,"Ion channel","Other nuclear protein","Membrane receptor",Kinase,"Voltage-gated ion channel","Cytochrome P450",Oxidoreductase,"Family A G protein-coupled receptor","Protein Kinase","Potassium 
channels","Cytochrome P450 family 3","Peptide receptor (family A GPCR)","AGC protein kinase group","Voltage-gated potassium channel","Cytochrome P450 family 3A","Chemokine receptor","CMGC protein kina
se group","CAMK protein kinase group","TK protein kinase group","STE protein kinase group","TKL protein kinase group","Other protein kinase group","AGC protein kinase PKN family","AGC protein kinase D
MPK family","AGC protein kinase PKC family","Cytochrome P450 3A4","AGC protein kinase RSK family","CC chemokine receptor","CMGC protein kinase CDK family","CAMK protein kinase PKD family","Tyrosine pr
otein kinase Alk family","STE protein kinase STE20 family","CMGC protein kinase CLK family","CAMK protein kinase CAMK1 family","AGC protein kinase PKG family","AGC protein kinase PKA family","TKL prot
ein kinase LRRK family","Other protein kinase IKK family","AGC protein kinase ROCK subfamily","AGC protein kinase PKC eta subfamily","AGC protein kinase MSK subfamily","AGC protein kinase PKC delta su
bfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK8 subfamily","STE protein kinase MST subfamily","AGC protein kinase GEK subfamily","CMGC protein kinase CDC2 subfamily","CAMK prot
ein kinase BRSK subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels",Receptors,"Kinases (EC 2.7.x.x)","Voltage-gated ion channels","Cytochrome P450","Eicosanoid turnover","Catalytic receptors","AGC: Containing PKA",PKG,"PKC families","Potassium 
channels","CYP3 family",Lipoxygenases,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","Receptor kinases","STE: Homologs of yeast Sterile 7","Steril
e 11","Sterile 20 kinases","Protein kinase N (PKN) family","DMPK family","Voltage-gated potassium channels","Protein kinase C (PKC) family","RSK family","Cyclin-dependent kinase (CDK) family","Protein
 kinase D (PKD) family","TK: Tyrosine kinase","STE20 family","CLK family","CAMK-like (CAMKL) family","Protein kinase G (PKG) family","Protein kinase A (PKA) family","TKL: Tyrosine kinase-like","Other 
protein kinases","Rho kinase","Eta subfamily","MSK subfamily","Delta subfamily","CDK5 subfamily","CDK8 subfamily","Receptor tyrosine kinases (RTKs)","MST subfamily","GEK subfamily","CDK1 subfamily","B
RSK subfamily","Leucine-rich repeat kinase (LRRK) family","IKK family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Muscle contraction","Immune System","Cell Cycle",Metabolism,"Gene expression (Transcription)",Disease,"Signaling by Rho GTPases","Nervous system develop
ment","Cardiac conduction","Innate Immune System",Mitotic,"Metabolism of lipids","Signaling by GPCR","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and s
econd messengers","Signaling by Hippo","Intracellular signaling by second messengers","MAPK family signaling cascades","Infectious disease","Signaling by Non-Receptor Tyrosine Kinases","RHO GTPase Eff
ectors","Axon guidance","Phase 3 - rapid repolarisation","Fcgamma receptor (FCGR) dependent phagocytosis","M Phase","Biosynthesis of specialized proresolving mediators (SPMs)","Toll-like Receptor Casc
ades","GPCR ligand binding","GPCR downstream signalling","Generic Transcription Pathway","Signaling by NOTCH1 in Cancer","Sphingolipid metabolism","DAG and IP3 signaling","MAPK1/MAPK3 signaling","Leis
hmania infection","Signaling by PTK6","Regulation of mitotic cell cycle","RHO GTPases activate PKNs","Semaphorin interactions","Role of phospholipids in phagocytosis","Mitotic Metaphase and Anaphase",
"Biosynthesis of DHA-derived SPMs","Biosynthesis of DPA-derived SPMs","Toll Like Receptor 5 (TLR5) Cascade","Class A/1 (Rhodopsin-like receptors)","G alpha (i) signalling events","Transcriptional Regu
lation by TP53","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","Sphingolipid de novo biosynthesis","CaM pathway","RAF/MAP kinase cascade","Leishmania parasite growth and survival","PTK6 promot
es HIF1A stabilization","Toll Like Receptor 4 (TLR4) Cascade","APC/C-mediated degradation of cell cycle proteins","Sema4D in semaphorin signaling","Mitotic Anaphase","Biosynthesis of maresins","Biosyn
thesis of DPAn-3 SPMs","MyD88 cascade initiated on plasma membrane","Peptide ligand-binding receptors","Visual phototransduction","Regulation of TP53 Activity","Constitutive Signaling by NOTCH1 HD+PES
T Domain Mutants","Calmodulin induced events","RAS processing","Anti-inflammatory response favouring Leishmania parasite infection","MyD88-independent TLR4 cascade","Activation of APC/C and APC/C:Cdc2
0 mediated degradation of mitotic proteins","Sema4D induced cell migration and growth-cone collapse","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","Biosynthesis of DPAn-3-deri
ved protectins and resolvins","MAP kinase activation","Chemokine receptors bind chemokines","The phototransduction cascade","Regulation of TP53 Activity through Phosphorylation","Regulation of TP53 Ex
pression and Degradation","ADORA2B mediated anti-inflammatory cytokines production","TRIF(TICAM1)-mediated TLR4 signaling","APC/C:Cdc20 mediated degradation of mitotic proteins","Initiation of Nuclear
 Envelope (NE) Reformation","MAPK targets/ Nuclear events mediated by MAP kinases",Inactivation,"recovery and regulation of the phototransduction cascade","Regulation of TP53 Degradation","IKK complex
 recruitment mediated by RIP1","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","CREB phosphorylation","Cdc20:Phospho-APC/C mediated degradatio
n of Cyclin A"}

> <broad_targets>
{PKIA,PKN2,PRKACA,PRKCE,ROCK1,ROCK2}

> <broad_moa>
{"rho associated kinase inhibitor"}

> <synonyms>
{"Cyclohexanecarboxamide, 4-(1-aminoethyl)-N-4-pyridinyl-, dihydrochloride",138381-45-0,CHEMBL540097,SCHEMBL2834049,EI-299,"Y-27632 2HCl"}

> <pdid>
PD004560

> <targets>
{Autophagy,ROCK}

> <classes>
{}

> <pubchem_cids>
{45265665}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  1  0            999 V2000
    6.0344    8.8940    0.0000 C   0  0
    5.6832    7.4357    0.0000 C   0  0
    6.7704    6.4012    0.0000 C   0  0  2  0  0  0
    7.8571    5.3671    0.0000 C   0  0
    8.2099    6.8259    0.0000 C   0  0
    9.2965    5.7919    0.0000 O   0  0
    8.5627    8.2847    0.0000 N   0  0
   10.0022    8.7094    0.0000 C   0  0
   10.3550   10.1682    0.0000 C   0  0
   11.7936   10.5927    0.0000 F   0  0
   10.7069   11.6263    0.0000 F   0  0
    9.2683   11.2022    0.0000 F   0  0
    6.4176    4.9424    0.0000 N   0  0
    4.9781    4.5176    0.0000 C   0  0
    4.6234    3.0602    0.0000 N   0  0
    3.1884    2.6409    0.0000 C   0  0
    2.0990    3.6745    0.0000 N   0  0
    2.4537    5.1320    0.0000 C   0  0
    3.8933    5.5535    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  1
  3  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
  9 12  1  0
  3 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 16 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 20  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28730

> <plate>
Kinase v5-3

> <well>
A19

> <supplier_cmpd_name>
Decernotinib (VX-509)

> <ctcr_id>
11520

> <supplier_cmpd_id>
S7541

> <smiles>
CC[C@](C)(C(=O)NCC(F)(F)F)Nc1nc(ncc1)c1c[nH]c2c1cccn2

> <pd_targets>
{JAK3,JAK1,JAK2,TYK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase JakA family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Immune System","Cell Cycle","Cytokine Signaling in Immune system",Mitotic,"Signaling by Interleukins","Interferon Signaling","Mitotic G1 phase and G1/S transition","Interleukin-2 family signaling","
Antiviral mechanism by IFN-stimulated genes","G1 Phase","Interferon alpha/beta signaling","Interleukin-15 signaling","ISG15 antiviral mechanism","Cyclin D associated events in G1","Regulation of IFNA 
signaling"}

> <broad_targets>
{JAK3}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{Decernotinib,944842-54-0,944842540,"944842 54 0",Adelatinib,VX-509,VX509,"VX 509","Decernotinib (VX-509)","Decernotinib (VX509)","Decernotinib (VX 509)",UNII-MZK2GP0RHK,UNIIMZK2GP0RHK,"UNII MZK2GP0RH
K",Decernotinib(VX-509),Decernotinib(VX509),T2636}

> <pdid>
PD016973

> <targets>
{JAK,JAK1,JAK2,JAK3,Tyk2}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors",Chromatin/Epigenetic,"JAK/STAT signaling","Stem Cells"}

> <pubchem_cids>
{59422203}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  1  0            999 V2000
    2.5988   -1.5004    0.0000 C   0  0  2  0  0  0
    2.5983   -3.0004    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
    3.8990   -0.7508    0.0000 C   0  0
    5.1976   -1.5016    0.0000 C   0  0
    6.4971   -0.7525    0.0000 C   0  0
    6.4980    0.7475    0.0000 C   0  0
    5.1995    1.4984    0.0000 C   0  0
    3.9000    0.7492    0.0000 C   0  0
    7.7982    1.4971    0.0000 C   0  0
    9.1502    0.8774    0.0000 C   0  0
   10.1528    1.9930    0.0000 N   0  0
    9.4016    3.2914    0.0000 N   0  0
    7.9347    2.9781    0.0000 C   0  0
    1.2718   -2.2619    0.0000 C   0  0
    1.2670   -3.7619    0.0000 N   0  0
  1  2  1  6
  1  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  6  9  1  0
  1 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 13 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 16  2  0
  1 21  1  0
 21 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28731

> <plate>
Kinase v5-3

> <well>
A21

> <supplier_cmpd_name>
AT13148

> <ctcr_id>
11741

> <supplier_cmpd_id>
S7563

> <smiles>
[C@](O)(c1ccc(cc1)Cl)(c1ccc(cc1)c1cn[nH]c1)CN

> <pd_targets>
{AKT3,AKT1,AKT2,RPS6KA1,RPS6KA2,RPS6KA3,RPS6KA4,RPS6KA5,RPS6KA6,RPS6KB1,RPS6KB2,MAPKAPK2,ROCK1,ROCK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","CAMK protein kinase group","AGC protein kinase AKT family","AGC protein kinase RSK family","CAMK protein kinase MAPKAPK family","AGC protein
 kinase DMPK family","AGC protein kinase MSK subfamily","CAMK protein kinase MAPKAPK subfamily","AGC protein kinase ROCK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","Akt (Protein kinase B","PKB) family","MAPK-Activated Protein Kinase (MAPK
APK) family","MAPKAPK subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Immune System","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Generic Transcription Pathwa
y","Signaling by Insulin receptor","Toll-like Receptor Cascades","Transcriptional Regulation by TP53","Insulin receptor signalling cascade","Toll Like Receptor 5 (TLR5) Cascade","Regulation of TP53 Ac
tivity","IRS-mediated signalling","MyD88 cascade initiated on plasma membrane","Regulation of TP53 Expression and Degradation","PI3K Cascade","MAP kinase activation","Regulation of TP53 Degradation","
PKB-mediated events","MAPK targets/ Nuclear events mediated by MAP kinases","PDE3B signalling","CREB phosphorylation"}

> <broad_targets>
{AKT1,AKT2,AKT3,ROCK1,ROCK2,SGK3}

> <broad_moa>
{"protein kinase inhibitor"}

> <synonyms>
{AT13148,1056901-62-2,1056901622,AT-13148,UNII-A49037RP1E,UNIIA49037RP1E,(S)-1-(4-(1H-Pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol,(S)1(4(1HPyrazol4yl)phenyl)2amino1(4chlorophenyl)ethanol,A4
9037RP1E,(1S)-2-amino-1-(4-chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethanol,(1S)2amino1(4chlorophenyl)1(4(1Hpyrazol4yl)phenyl)ethanol,SCHEMBL851471,CHEMBL3544960,BCP08961,EX-A1797,EXA1797,2231AH,T24
82}

> <pdid>
PD021580

> <targets>
{Akt,"S6 Kinase",ROCK,PKA,Akt1,Akt2,Akt3,ROCK1,ROCK2,"p70 S6K",RSK1,SGK3,"Ribosomal S6 Kinase (RSK)"}

> <classes>
{Cytoskeletal Signaling,Cell Cycle/Checkpoint,GPCR/G Protein,Metabolism,PI3K/Akt/mTOR signaling,Stem Cells,Cell Cycle/DNA Damage,Cytoskeleton,MAPK/ERK Pathway,PI3K/Akt/mTOR,Protein Tyrosine Kinase/RTK
,Stem Cell/Wnt,TGF-beta/Smad}

> <pubchem_cids>
{24905401}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    1.6317   -2.2458    0.0000 C   0  0
    0.7500   -1.0323    0.0000 C   0  0
    1.2135    0.3943    0.0000 N   0  0
    0.0000    1.2760    0.0000 C   0  0
   -0.0031    2.7742    0.0000 N   0  0
   -1.3040    3.5228    0.0000 C   0  0
   -2.6017    2.7705    0.0000 O   0  0
   -1.3071    5.0236    0.0000 N   0  0
   -0.0936    5.8834    0.0000 C   0  0
   -0.5571    7.3100    0.0000 C   0  0
   -2.0571    7.3100    0.0000 C   0  0
   -2.5206    5.8834    0.0000 C   0  0
   -3.9429    5.4124    0.0000 C   0  0
   -5.0639    6.4090    0.0000 O   0  0
   -4.2459    3.9433    0.0000 N   0  0
   -1.2135    0.3943    0.0000 S   0  0
   -0.7500   -1.0323    0.0000 C   0  0
   -1.6321   -2.2464    0.0000 C   0  0
   -3.1114   -2.3441    0.0000 C   0  0
   -3.4619   -3.8026    0.0000 S   0  0
   -2.1831   -4.5866    0.0000 C   0  0
   -1.0423   -3.6127    0.0000 N   0  0
   -2.0659   -6.0803    0.0000 C   0  0
   -3.3018   -6.9304    0.0000 C   0  0
   -0.7120   -6.7259    0.0000 C   0  0
   -1.9479   -7.5756    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  8  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
  4 16  1  0
 16 17  1  0
 17  2  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 18  1  0
 21 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28732

> <plate>
Kinase v5-3

> <well>
A03

> <supplier_cmpd_name>
A66

> <ctcr_id>
1915

> <supplier_cmpd_id>
S2636

> <smiles>
Cc1nc(NC(=O)N2CCCC2C(=O)N)sc1c3csc(n3)C(C)(C)C

> <pd_targets>
{PIK3CB,PIK3CG,PIK3C2B,PIK3CA,PIK3CD}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidylinositol-4-phosphate 3-kinase family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,Disease,"Immune System","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second messeng
ers","Cytokine Signaling in Immune system","Signaling by Insulin receptor","Phospholipid metabolism","Signaling by FGFR in disease","Signaling by Interleukins","Insulin receptor signalling cascade","P
I Metabolism","Signaling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","IRS-mediated signalling","Synthesis of PIPs at the plasma membrane","FGFR1 mutant receptor activation"
,"Interleukin receptor SHC signaling","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
{PIK3CA}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{SCHEMBL12700770,HMS3656L07,HMS3672C17,AKOS026750475,NCGC00389613-01,NCGC0038961301,AK279970,SY-A66,S2636,A66}

> <pdid>
PD010905

> <targets>
{PI3K,PIK3,"alpha PIK3CA"}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{74832860}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  1  0            999 V2000
    2.5800    0.0305    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    3.7500    0.0000 C   0  0
   -5.1962    3.0000    0.0000 C   0  0  2  0  0  0
   -5.1962    1.5000    0.0000 C   0  0
   -6.4959    3.7503    0.0000 C   0  0
   -7.7962    3.0025    0.0000 C   0  0
   -9.0940    3.7545    0.0000 C   0  0
   -9.0917    5.2545    0.0000 C   0  0
   -7.7914    6.0025    0.0000 C   0  0
   -6.4936    5.2504    0.0000 C   0  0
  -10.3895    6.0066    0.0000 O   0  0
   -7.7986    1.5025    0.0000 O   0  0
    1.2638   -2.2496    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  2  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  5  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 10  1  0
 14 16  1  6
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 19 22  1  0
 17 23  1  0
  2 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28733

> <plate>
Kinase v5-3

> <well>
A05

> <supplier_cmpd_name>
Glabridin

> <ctcr_id>
12683

> <supplier_cmpd_id>
S3786

> <smiles>
CC1(C=Cc2c(O1)ccc1c2OC[C@H](C1)c1c(cc(cc1)O)O)C

> <pd_targets>
{TYR,CYP3A4,PTPN1}

> <pathway_gtopdb>
{Enzyme,Oxidoreductase,"Cytochrome P450",Phosphatase,"Cytochrome P450 family 3","Protein Phosphatase","Cytochrome P450 family 3A","Tyrosine protein phosphatase","Cytochrome P450 3A4"}

> <pathway_chembl>
{Enzymes,"1.-.-.- Oxidoreductases","Cytochrome P450",Phosphatases,"CYP3 family","Protein tyrosine phosphatases non-receptor type (PTPN)"}

> <pathway_reactome>
{Metabolism,"Gene expression (Transcription)","Metabolism of amino acids and derivatives","Metabolism of lipids","RNA Polymerase II Transcription","Melanin biosynthesis","Biosynthesis of specialized p
roresolving mediators (SPMs)","Generic Transcription Pathway","Biosynthesis of DHA-derived SPMs","Transcriptional Regulation by MECP2","Biosynthesis of maresins","MECP2 regulates neuronal receptors an
d channels","Biosynthesis of maresin-like SPMs"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Glabridin,59870-68-7,59870687,UNII-HOC5567T41,UNIIHOC5567T41,CHEBI:5369,HOC5567T41,MFCD03427694,"4-((3R)-8,8-DIMETHYL-2H,3H,4H,8H-PYRANO(2,3-F)CHROMEN-3-YL)BENZENE-1,3-DIOL","4((3R)8,8DIMETHYL2H,3H,4
H,8HPYRANO(2,3F)CHROMEN3YL)BENZENE1,3DIOL",GlaBioidin,glabridine;,MLS000697609,BIDD:ER0172,"Glabridin, analytical standard",SCHEMBL114869,T3403}

> <pdid>
PD041063

> <targets>
{"GABA Receptor",PPAR,"T1 tyrosinase","T3 tyrosinase"}

> <classes>
{Proteases/Proteasome}

> <pubchem_cids>
{124052}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 25  0  0  0  0            999 V2000
    4.8817   -2.5602    0.0000 O   0  0
    3.8794   -1.4442    0.0000 N   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.8244   -5.7203    0.0000 C   0  0
    0.3359   -5.9054    0.0000 O   0  0
    2.8574   -6.8079    0.0000 N   0  0
    4.2102   -6.1617    0.0000 C   0  0
    5.5962   -6.7352    0.0000 C   0  0
    6.7859   -5.8216    0.0000 C   0  0
    8.1719   -6.3951    0.0000 Br  0  0
    6.5895   -4.3345    0.0000 C   0  0
    5.2035   -3.7610    0.0000 C   0  0
    4.0138   -4.6746    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9  4  1  0
  9 10  2  3
 10 11  1  0
 11  3  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 18 20  2  0
 20 21  1  0
 21 22  2  0
 22 12  1  0
 22 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28736

> <plate>
Kinase v5-3

> <well>
A11

> <supplier_cmpd_name>
BIO

> <ctcr_id>
8357

> <supplier_cmpd_id>
Se S7198

> <smiles>
ONC/1=C2C=CC=CC2=NC1=C3/C(=O)Nc4cc(Br)ccc34

> <pd_targets>
{CDK1,CDK5}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","CDK5 subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)",Mitotic,"RNA Polymerase II Transcription","Regulation of mitotic cell cycle","Generic Transcription Pathway","APC/C-mediated degradation of cell cycle p
roteins","Transcriptional Regulation by TP53","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity","APC/C:Cdc20 mediated degradation of mitotic 
proteins","Regulation of TP53 Activity through Phosphorylation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Cdc20:Phospho-APC/C mediated 
degradation of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{CHEMBL243555,667463-62-9,667463629,"667463 62 9",BIO,6-BROMOINDIRUBIN-3'-OXIME,6BROMOINDIRUBIN3'OXIME,"6 BROMOINDIRUBIN 3' OXIME","GSK-3 Inhibitor IX","GSK3 Inhibitor IX","GSK 3 Inhibitor IX",6BIO,6-
bromoindirubin-3-oxime,6bromoindirubin3oxime,6bromoindirubin3oxim,3194}

> <pdid>
PD039018

> <targets>
{}

> <classes>
{}

> <pubchem_cids>
{448949}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.6012    3.0008    0.0000 N   0  0
   -3.9020    3.7494    0.0000 C   0  0
   -3.9073    5.2494    0.0000 C   0  0
   -5.2089    5.9949    0.0000 C   0  0
   -6.5053    5.2404    0.0000 C   0  0
   -6.5002    3.7404    0.0000 C   0  0
   -5.1985    2.9949    0.0000 C   0  0
   -7.8070    5.9859    0.0000 Cl  0  0
   -5.2141    7.4949    0.0000 Cl  0  0
   -2.6109    6.0039    0.0000 F   0  0
    2.5972    1.5031    0.0000 O   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8915    3.7585    0.0000 C   0  0
    3.8863    5.2585    0.0000 C   0  0
    2.5847    6.0040    0.0000 N   0  0
    1.2883    5.2495    0.0000 C   0  0
    1.2934    3.7495    0.0000 C   0  0
    2.5764    7.5048    0.0000 C   0  0
    3.8715    8.2616    0.0000 O   0  0
    1.2730    8.2489    0.0000 C   0  0
    1.2647    9.7488    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  7  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  6  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 16 21  1  0
 15 22  1  0
  4 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 27 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  2  0
M  END
> <name>
UTKinase_V5

> <id>
28738

> <plate>
Kinase v5-3

> <well>
A15

> <supplier_cmpd_name>
Poziotinib (HM781-36B)

> <ctcr_id>
11529

> <supplier_cmpd_id>
Se S7358

> <smiles>
COc1c(cc2c(c1)ncnc2Nc1c(c(c(cc1)Cl)Cl)F)OC1CCN(CC1)C(=O)C=C

> <pd_targets>
{EGFR,ERBB2,ERBB4,ERBB3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology","Neuronal System","Signaling by GPCR","Nervous system development","Transmission across Chemical Synapses","GPCR downstream signalling","Axon guidance","
Neurotransmitter receptors and postsynaptic signal transmission","G alpha (q) signalling events","Semaphorin interactions","Activation of NMDA receptors and postsynaptic events","Gastrin-CREB signalli
ng pathway via PKC and MAPK","Sema4D in semaphorin signaling","Post NMDA receptor activation events","EGFR Transactivation by Gastrin","Sema4D induced cell migration and growth-cone collapse","Long-te
rm potentiation"}

> <broad_targets>
{EGFR,ERBB2,ERBB4}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{Poziotinib,1092364-38-9,1092364389,UNII-OEI6OOU6IK,UNIIOEI6OOU6IK,HM781-36B,HM78136B,NOV120101,OEI6OOU6IK,HM-78136B,NOV-120101,MFCD28044290,"1092364-38-9 (free base)","1092364389 (free base)","HM 781
-36B","HM 78136B",HM-781-36B,"Poziotinib (INN)","Poziotinib (HM781-36B)","Poziotinib (HM78136B)",Tube707,C23H21Cl2FN4O3,GTPL7903,SCHEMBL33917,T2630}

> <pdid>
PD012535

> <targets>
{HER2,EGFR,HER1,HER4,Apoptosis}

> <classes>
{Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors,Apoptosis,JAK/STAT Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{25127713}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
  -10.3879   -5.9453    0.0000 C   0  0
  -10.4003   -7.4453    0.0000 C   0  0
   -9.1074   -8.2073    0.0000 N   0  0
   -9.1177   -9.7073    0.0000 C   0  0
   -7.8238  -10.4662    0.0000 C   0  0
   -6.5196   -9.7252    0.0000 N   0  0
   -6.5093   -8.2252    0.0000 C   0  0
   -7.8032   -7.4663    0.0000 C   0  0
   -5.2235  -10.4819    0.0000 C   0  0
   -3.9196   -9.7386    0.0000 C   0  0
   -2.6232  -10.4931    0.0000 C   0  0
   -1.3216   -9.7476    0.0000 C   0  0
   -1.3163   -8.2475    0.0000 C   0  0
   -2.6129   -7.4931    0.0000 C   0  0
   -3.9145   -8.2387    0.0000 C   0  0
   -0.0155   -7.4989    0.0000 C   0  0
    1.2822   -8.2512    0.0000 O   0  0
   -0.0125   -5.9981    0.0000 N   0  0
    1.2883   -5.2495    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    5.1932   -3.0130    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.5532    4.4223    0.0000 O   0  0
   -0.3115    2.9665    0.0000 C   0  0
   -2.6283  -11.9939    0.0000 C   0  0
   -3.9294  -12.7403    0.0000 F   0  0
   -1.3316  -12.7479    0.0000 F   0  0
   -2.6327  -13.4939    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  6  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 13 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 22 25  1  0
 21 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 30 33  1  0
 33 34  1  0
 34 35  2  0
 34 36  1  0
 36 29  1  0
 11 37  1  0
 37 38  1  0
 37 39  1  0
 37 40  1  0
M  END
> <name>
UTKinase_V5

> <id>
28739

> <plate>
Kinase v5-3

> <well>
A17

> <supplier_cmpd_name>
DDR1-IN-1

> <ctcr_id>
12127

> <supplier_cmpd_id>
S7498

> <smiles>
CCN1CCN(CC1)Cc1c(cc(cc1)C(=O)Nc1cc(c(cc1)C)Oc1cc2c(cc1)NC(=O)C2)C(F)(F)F

> <pd_targets>
{DDR1,DDR2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase DDR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XVI RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Extracellular matrix organization","Non-integrin membrane-ECM interactions"}

> <broad_targets>
{DDR1,DDR2}

> <broad_moa>
{"discoidin domain receptor inhibitor"}

> <synonyms>
{DR1IN,DDR1-IN-1,DDR1IN1,1449685-96-4,1449685964,DDR-IN-1,DDRIN1,GTPL9354,CHEMBL3421914,BDBM104009,"DDR1-IN 1; DDR1-IN1","DDR1IN 1; DDR1IN1",BCP10994,EX-A1313,EXA1313,s7498,ZINC96174842,CCG-270013,CCG
270013,SB19064,NCGC00378613-03,NCGC0037861303,HY-13979,HY13979,J3.552.499A,Q27459290,T3337,Ddr1-In-1}

> <pdid>
PD003241

> <targets>
{Others,DDR1,DDR2}

> <classes>
{"GPCR/G Protein",Neuroscience}

> <pubchem_cids>
{72836888}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 24  0  0  0  0            999 V2000
    1.2948   -3.7516    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 S   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1944   -3.0088    0.0000 C   0  0
    6.4947   -2.2611    0.0000 N   0  0
    3.8912   -5.2578    0.0000 C   0  0
    2.5895   -6.0034    0.0000 C   0  0
    2.5844   -7.5034    0.0000 C   0  0
    3.8808   -8.2579    0.0000 C   0  0
    5.1824   -7.5124    0.0000 C   0  0
    5.1876   -6.0124    0.0000 C   0  0
    6.4900   -5.2665    0.0000 C   0  0
    7.7869   -6.0202    0.0000 F   0  0
    6.4947   -3.7665    0.0000 F   0  0
    7.7913   -4.5204    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  7  9  1  0
  9 10  2  0
 10  4  1  0
  2 11  2  0
 11 12  1  0
 12 13  3  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 20 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28740

> <plate>
Kinase v5-3

> <well>
D06

> <supplier_cmpd_name>
SL-327

> <ctcr_id>
7690

> <supplier_cmpd_id>
S1066

> <smiles>
N\C(Sc1ccc(N)cc1)=C(C#N)/c2ccccc2C(F)(F)F

> <pd_targets>
{MAP2K2,RORC,HSD17B10,JUN,MAPK1,CYP3A4,MAPT,ALOX15,FTL,ALDH1A1,KMT2A,MEN1}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Other cytosolic protein","Unclassified protein","Epigenetic regulator",Kinase,"Nuclear receptor",Oxidoreductase,"Cytochrome P450",Reader,"Protein Kinase","Nuclear hormo
ne receptor subfamily 1","Cytochrome P450 family 3",Bromodomain,"STE protein kinase group","Nuclear hormone receptor subfamily 1 group F","CMGC protein kinase group","Cytochrome P450 family 3A","STE p
rotein kinase STE7 family","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase MAPK family","Cytochrome P450 3A4","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Cytochrome P450","Eicosanoid turnover","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","1F. Retinoic acid-re
lated orphans","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP3 family",Lipoxygenases,"STE7 family","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Metabolism,"Immune System","Neuronal System","Vesicle-mediated transport","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcrip
tion","Metabolism of amino acids and derivatives","Innate Immune System","Metabolism of lipids","Transmission across Chemical Synapses","Membrane Trafficking","Biological oxidations","Signaling by NTR
Ks","Generic Transcription Pathway","Branched-chain amino acid catabolism","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving mediators (SPMs)","Neurotransmitter receptors and pos
tsynaptic signal transmission","trans-Golgi Network Vesicle Budding","Phase I - Functionalization of compounds","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX3","Toll Like Receptor 5 
(TLR5) Cascade","Biosynthesis of DHA-derived SPMs","Activation of NMDA receptors and postsynaptic events","Biosynthesis of DPA-derived SPMs","Golgi Associated Vesicle Biogenesis","Ethanol oxidation","
Signalling to ERKs","RUNX3 Regulates Immune Response and Cell Migration","MyD88 cascade initiated on plasma membrane","Biosynthesis of maresins","Post NMDA receptor activation events","Biosynthesis of
 DPAn-3 SPMs","Prolonged ERK activation events","MAP kinase activation","Biosynthesis of maresin-like SPMs","Activation of AMPK downstream of NMDARs","Biosynthesis of DPAn-3-derived protectins and res
olvins","Frs2-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SL327,305350-87-2,305350872,"305350 87 2",SL-327,"SL 327","MEK1/2 Inhibitor",C16H12F3N3S,MFCD06411432,K00090,SCHEMBL570317,SCHEMBL570318,GTPL6008,CHEBI:92211,AOB5954,DTXSID90429549,HMS3229K18,HMS3414
M21,HMS3678M21,HMS3884G03,BCP05310,EX-A1069,EXA1069,EXA106,"EMD 444939",1969,444939}

> <pdid>
PD011155

> <targets>
{MEK}

> <classes>
{}

> <pubchem_cids>
{9549284}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    2.6030   -2.9977    0.0000 O   0  0
    2.6003   -1.4977    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    3.8939    0.7546    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 C   0  0
   -0.0072    7.5009    0.0000 Cl  0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  3  1  0
  2  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  9  1  0
 18 13  1  0
 11 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28741

> <plate>
Kinase v5-3

> <well>
C19

> <supplier_cmpd_name>
Vacquinol-1

> <ctcr_id>
6502

> <supplier_cmpd_id>
Se S7544

> <smiles>
OC(C1CCCCN1)c2cc(nc3ccccc23)c4ccc(Cl)cc4

> <pd_targets>
{RORC,NPSR1,KMT2A,MEN1,FFP,MAPK1,MAPT}

> <pathway_gtopdb>
{"Transcription factor","Membrane receptor","Epigenetic regulator",Enzyme,"Other cytosolic protein","Nuclear receptor","Family A G protein-coupled receptor",Reader,Transferase,Kinase,"Nuclear hormone 
receptor subfamily 1","Peptide receptor (family A GPCR)",Bromodomain,"Protein Kinase","Nuclear hormone receptor subfamily 1 group F","Short peptide receptor (family A GPCR)","CMGC protein kinase group
","Nuclear hormone receptor subfamily 1 group F member 3","Neuropeptide receptor","CMGC protein kinase MAPK family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","G protein-coupled receptors","Kinases (EC 2.7.x.x)","1F. Retinoic acid-related orphans","Neuropeptide S receptor","CMGC: Containing CDK",MAPK,GSK3,"CLK 
families","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,"Immune System","Neuronal System","RNA Polymerase II Transcription","Infectious disease","Innate Immune System","Transmission across Chemical Synapses","Gene
ric Transcription Pathway","Leishmania infection","Toll-like Receptor Cascades","Neurotransmitter receptors and postsynaptic signal transmission","Transcriptional regulation by RUNX3","Leishmania para
site growth and survival","Toll Like Receptor 5 (TLR5) Cascade","Activation of NMDA receptors and postsynaptic events","RUNX3 Regulates Immune Response and Cell Migration","Anti-inflammatory response 
favouring Leishmania parasite infection","MyD88 cascade initiated on plasma membrane","Post NMDA receptor activation events","ADORA2B mediated anti-inflammatory cytokines production","MAP kinase activ
ation","Activation of AMPK downstream of NMDARs","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{vacquinol-1,vacquinol1,5428-80-8,5428808,NSC13316,(2-(4-chlorophenyl)quinolin-4-yl)-piperidin-2-ylmethanol,(2(4chlorophenyl)quinolin4yl)piperidin2ylmethanol,(2-(4-chlorophenyl)quinolin-4-yl)(piperidi
n-2-yl)methanol,(2(4chlorophenyl)quinolin4yl)(piperidin2yl)methanol,MLS000737413,(2-(4-chlorophenyl)quinolin-4-yl)-(2-piperidyl)methanol,(2(4chlorophenyl)quinolin4yl)(2piperidyl)methanol,(2-(4-chlorop
henyl)-4-quinol,(2(4chlorophenyl)4quinol,T7008,"NSC 13316",Vacquinol-1}

> <pdid>
PD017932

> <targets>
{JNK}

> <classes>
{}

> <pubchem_cids>
{224644}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 46  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -1.2948    3.7516    0.0000 O   0  0
   -3.8933    3.7570    0.0000 O   0  0
   -3.8912    5.2578    0.0000 C   0  0
   -5.1876    6.0124    0.0000 C   0  0
   -6.4893    5.2669    0.0000 C   0  0
   -5.1824    7.5124    0.0000 C   0  0
   -3.8808    8.2579    0.0000 C   0  0
   -2.5844    7.5034    0.0000 C   0  0
   -2.5896    6.0034    0.0000 C   0  0
   -1.2931    5.2490    0.0000 C   0  0
   -3.8982    0.7550    0.0000 C   0  0
   -5.1971    1.5054    0.0000 N   0  0
   -6.4964    0.7559    0.0000 C   0  0
   -7.7975    1.5041    0.0000 N   0  0
   -9.0964    0.7523    0.0000 C   0  0
  -10.3979    1.4982    0.0000 C   0  0
  -11.6946    0.7442    0.0000 C   0  0
  -11.6899   -0.7558    0.0000 C   0  0
  -12.9873   -1.5101    0.0000 N   0  0
  -14.2899   -0.7663    0.0000 C   0  0
  -15.5854   -1.5223    0.0000 C   0  0
  -15.5784   -3.0223    0.0000 N   0  0
  -16.8740   -3.7784    0.0000 C   0  0
  -14.2759   -3.7662    0.0000 C   0  0
  -12.9804   -3.0102    0.0000 C   0  0
  -10.3886   -1.5017    0.0000 C   0  0
   -9.0919   -0.7477    0.0000 C   0  0
   -6.4970   -0.7441    0.0000 N   0  0
   -5.1982   -1.4946    0.0000 C   0  0
   -3.8989   -0.7451    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 O   0  0
   -2.5951   -3.0031    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 11  1  0
 17 18  1  0
  7 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 30 32  1  0
 32 33  1  0
 33 27  1  0
 26 34  1  0
 34 35  2  0
 35 23  1  0
 21 36  2  0
 36 37  1  0
 37 38  2  0
 38 19  1  0
  6 39  1  0
 39 40  1  0
 40 41  1  0
 39 42  2  0
 42  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28742

> <plate>
Kinase v5-3

> <well>
C21

> <supplier_cmpd_name>
WH-4-023

> <ctcr_id>
12359

> <supplier_cmpd_id>
S7565

> <smiles>
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2)c(OC)c1

> <pd_targets>
{SRC,KDR,LCK,MAPK14}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","CMGC protein kinase MAPK family","CMG
C protein kinase p38 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases
)","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","p38 subfamily","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System","Signaling by Receptor Tyrosine Kinases","Infectious disease","Innate Immune System","Signaling by NTRKs","Signaling by VEGF","HIV Infection","Toll-like 
Receptor Cascades","Signaling by NTRK1 (TRKA)","VEGFA-VEGFR2 Pathway","Host Interactions of HIV factors","Toll Like Receptor 5 (TLR5) Cascade","Signalling to ERKs","VEGFR2 mediated cell proliferation"
,"The role of Nef in HIV-1 replication and disease pathogenesis","MyD88 cascade initiated on plasma membrane","Signalling to RAS","Nef-mediates down modulation of cell surface receptors by recruiting 
them to clathrin adapters","MAP kinase activation","p38MAPK events","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcri
ption factors"}

> <broad_targets>
{LCK,SRC}

> <broad_moa>
{"SRC inhibitor"}

> <synonyms>
{H402,WH-4-023,WH4023,837422-57-8,837422578,HMSL10038,KIN001-112,KIN001112,KIN112,"CID 11844351",CHEMBL213100,GTPL8068,SCHEMBL5755186,"2-aminopyrimidine carbamate, 28","2aminopyrimidine carbamate, 28"
,BDBM17729,CHEBI:94644,AOB6574,C32H36N6O4,HMS3265G11,HMS3653D15,HMS3750E09,BCP10090,EX-A1078,EXA1078,2801AH,MFCD28138072,T1811}

> <pdid>
PD003233

> <targets>
{Src,Lck}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{11844351}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2526    1.3618    0.0000 C   0  0
   -6.2524    0.2436    0.0000 C   0  0
   -7.7447    0.3952    0.0000 O   0  0
   -5.4979   -1.0529    0.0000 N   0  0
   -4.0317   -0.7359    0.0000 C   0  0
   -2.9076   -1.7290    0.0000 O   0  0
   -5.5610    2.8305    0.0000 C   0  0
   -7.0220    3.1784    0.0000 C   0  0
   -7.4458    4.6173    0.0000 C   0  0
   -6.4116    5.7038    0.0000 C   0  0
   -4.9536    5.3514    0.0000 C   0  0
   -4.5297    3.9126    0.0000 C   0  0
   -3.0706    3.5612    0.0000 N   0  3
   -2.6461    2.1225    0.0000 O   0  5
   -2.0366    4.6478    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12  7  1  0
 12 13  2  0
  8 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 20 22  2  0
  5 23  1  0
 23 24  2  0
 24  2  1  0
 24 25  1  0
M  CHG  2  20   1  21  -1
M  END
> <name>
UTKinase_V5

> <id>
28743

> <plate>
Kinase v5-3

> <well>
C03

> <supplier_cmpd_name>
SB415286

> <ctcr_id>
2002

> <supplier_cmpd_id>
S2729

> <smiles>
Oc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl

> <pd_targets>
{GSK3B,THPO,GSK3A,ALDH1A1,ALD,CHRM1,CYP3A4,DYRK1A,GAA,CYP2C9,NFKB1,MAPT,CYP2C19,NS1,BLM,LMNA,TGR,FFP,HPGD,RORC,POLB,GMNN,CYP1A2,CCNB1,CCNB2,CCNB3,CDK1,HSD17B10,PMP22,CCNA1,CCNA2,CDK2,KMT2A,MEN1,SMN1,T
SHR,HIF1A,CDK5,CDK5R1,FTL}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Membrane receptor","Other cytosolic protein","Other nuclear protein","Transcription factor","Epigenetic regulator",Kinase,Oxidoreductase,"Family A G protein-coupled rec
eptor","Cytochrome P450",Hydrolase,Transferase,"Nuclear receptor",Reader,"Protein Kinase","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Nuclear hormo
ne receptor subfamily 1","Cytochrome P450 family 1",Bromodomain,"Methyl-lysine/arginine binding protein","Peptide receptor (family A GPCR)","CMGC protein kinase group","Monoamine receptor","Cytochrome
 P450 family 3A","Cytochrome P450 family 2C","Nuclear hormone receptor subfamily 1 group F","Cytochrome P450 family 1A","Tudor domain","Glycohormone receptor","CMGC protein kinase GSK family","Acetylc
holine receptor","Cytochrome P450 3A4","CMGC protein kinase DYRK family","Cytochrome P450 2C9","Cytochrome P450 2C19","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 1A1","CMG
C protein kinase CDK family","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","G protein-coupled receptors","Cytochrome P450","3.2.1.- Glycosidases","Eicosanoid turnover","Nuclear hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK
 families","Acetylcholine receptors (muscarinic)","CYP3 family","CYP2 family: drug metabolising subset","Prostaglandin synthases","1F. Retinoic acid-related orphans","CYP1 family","Glycoprotein hormon
e receptors","Glycogen synthase kinase (GSK) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","GSK subfamily","Dyrk1 subfamily"}

> <pathway_reactome>
{Disease,Hemostasis,Metabolism,"Signal Transduction","Cell Cycle","Immune System","Neuronal System","DNA Repair","Gene expression (Transcription)","Developmental Biology","Metabolism of RNA","Cellular
 responses to external stimuli","Vesicle-mediated transport","Infectious disease","Platelet activation","signaling and aggregation","Biological oxidations","Signaling by GPCR","Metabolism of lipids",M
itotic,"Diseases of metabolism","Cytokine Signaling in Immune system","Transmission across Chemical Synapses","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Base Excision Repair",
"Metabolism of amino acids and derivatives","Nervous system development","Metabolism of non-coding RNA","Cellular responses to stress","Membrane Trafficking","SARS-CoV Infections","Platelet Aggregatio
n (Plug Formation)","Phase I - Functionalization of compounds","GPCR ligand binding","Biosynthesis of specialized proresolving mediators (SPMs)","Mitotic G1 phase and G1/S transition","Diseases of car
bohydrate metabolism","Signaling by Interleukins","Neurotransmitter receptors and postsynaptic signal transmission","Homology Directed Repair","M Phase","Generic Transcription Pathway","Resolution of 
Abasic Sites (AP sites)","Branched-chain amino acid catabolism","EGR2 and SOX10-mediated initiation of Schwann cell myelination","snRNP Assembly","Leishmania infection","Cellular response to hypoxia",
"trans-Golgi Network Vesicle Budding","SARS-CoV-1 Infection","Ethanol oxidation","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","G0 and Early G1","Glycogen storage diseases"
,"Cytochrome P450 - arranged by substrate type","Interleukin-1 family signaling","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Ann
ealing (SSA)","Mitotic Metaphase and Anaphase","Transcriptional regulation by RUNX3","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","G1/S Transition","Leishmania parasi
te growth and survival","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Golgi Associated Vesicle Biogenesis","SARS-CoV-1 Genome Replication and Transcription","Amine ligand
-binding receptors","Biosynthesis of maresins","Glycogen storage disease type II (GAA)",Xenobiotics,"Interleukin-1 signaling","Post NMDA receptor activation events","HDR through Homologous Recombinati
on (HRR)","Mitotic Anaphase","Biosynthesis of D-series resolvins","RUNX3 Regulates Immune Response and Cell Migration","PCNA-Dependent Long Patch Base Excision Repair","Activation of the pre-replicati
ve complex","Anti-inflammatory response favouring Leishmania parasite infection","Replication of the SARS-CoV-1 genome","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","CYP2E1
 reactions","MAP3K8 (TPL2)-dependent MAPK1/3 activation","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","Nuclear Envelope (NE) Reassembly","Aromatic amines can 
be N-hydroxylated or N-dealkylated by CYP1A2","ADORA2B mediated anti-inflammatory cytokines production","Presynaptic phase of homologous DNA pairing and strand exchange","Initiation of Nuclear Envelop
e (NE) Reformation"}

> <broad_targets>
{GSK3A,GSK3B,RPS6KB1}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{264218-23-7,264218237,"SB 415286",SB-415286,SB415286,"3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione","3(3chloro4hydroxyphenylamino)4(2nitrophenyl)1Hpyrrole2,5dione","3-(3-c
hloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione","3(3chloro4hydroxyphenylamino)4(4nitrophenyl)1Hpyrrole2,5dione",CHEMBL322970,3-((3-chloro-4-hydroxyphenyl)amino)-4-(,3((3chloro4hydr
oxyphenyl)amino)4(,T6659,1617,S2729}

> <pdid>
PD002735

> <targets>
{GSK-3}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{4210951}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 15  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.8971    3.7500    0.0000 O   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11  5  2  0
 11 12  1  0
 12 13  2  0
 13  3  1  0
 13 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28744

> <plate>
Kinase v5-3

> <well>
C05

> <supplier_cmpd_name>
Scopoletin

> <ctcr_id>
1099

> <supplier_cmpd_id>
S3881

> <smiles>
COc1cc2C=CC(=O)Oc2cc1O

> <pd_targets>
{HSD17B10,HIF1A,HPGD,CA7,AKR1B1,CASP7,LEF,CA1,CA12,KDM4E,GLA,CASP1,CA9,ALDH1A1,GAA,IMPA1,CA13,ERAP1,RECQL,GFER,KMT2A,MEN1,CYP1A2,ACHE,ALOX15}

> <pathway_gtopdb>
{Enzyme,"Transcription factor","Epigenetic regulator",Oxidoreductase,Lyase,Protease,Eraser,Hydrolase,Reader,"Cytochrome P450","Cysteine protease","Metallo protease","Lysine demethylase",Bromodomain,"C
ytochrome P450 family 1","Cysteine protease CD clan","Metallo protease MAE clan","Jumonji domain-containing","Cysteine protease CA clan","Cytochrome P450 family 1A","Cysteine protease C14 family","Met
allo protease M34 family","Cysteine protease C1A family","Metallo protease M1 family","Cytochrome P450 1A1"}

> <pathway_chembl>
{Enzymes,"Eicosanoid turnover","Carbonic anhydrases","1.-.-.- Oxidoreductases","Peptidases and proteinases","Chromatin modifying enzymes","3.2.1.- Glycosidases","Inositol phosphate turnover","Cytochro
me P450","Acetylcholine turnover","Prostaglandin synthases","CD: Cysteine (C) Peptidases","1.14.11.- Histone demethylases","Inositol monophosphatase","MA: Metallo (M) Peptidases","CYP1 family",Lipoxyg
enases,"C14: Caspase","M1: Aminopeptidase N"}

> <pathway_reactome>
{Metabolism,"Cellular responses to external stimuli","Programmed Cell Death",Disease,"Immune System","Gene expression (Transcription)","Protein localization","Metabolism of amino acids and derivatives
","Cellular responses to stress","Metabolism of lipids","Reversible hydration of carbon dioxide",Apoptosis,"Infectious disease","Cytokine Signaling in Immune system","RNA Polymerase II Transcription",
"Biological oxidations","Diseases of metabolism","Inositol phosphate metabolism","Adaptive Immune System","Mitochondrial protein import","Branched-chain amino acid catabolism","Cellular response to hy
poxia","Biosynthesis of specialized proresolving mediators (SPMs)","Metabolism of steroids","Intrinsic Pathway for Apoptosis","Uptake and actions of bacterial toxins","Signaling by Interleukins","Sphi
ngolipid metabolism","Generic Transcription Pathway","Phase I - Functionalization of compounds","Diseases of carbohydrate metabolism","Synthesis of IP2",IP,"and Ins in the cytosol","Class I MHC mediat
ed antigen processing & presentation","Phospholipid metabolism","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Biosynthesis of DHA-derived SPMs","Metabolism of steroid hor
mones","Apoptotic factor-mediated response","Uptake and function of anthrax toxins","Interleukin-12 family signaling","Glycosphingolipid metabolism","Transcriptional Regulation by TP53","Regulation of
 gene expression by Hypoxia-inducible Factor","Ethanol oxidation","Glycogen storage diseases","Antigen Presentation: Folding","assembly and peptide loading of class I MHC","Cytochrome P450 - arranged 
by substrate type","Glycerophospholipid biosynthesis","Biosynthesis of DPA-derived SPMs","Biosynthesis of D-series resolvins","Pregnenolone biosynthesis","Cytochrome c-mediated apoptotic response","In
terleukin-12 signaling","TP53 Regulates Transcription of Cell Death Genes","Glycogen storage disease type II (GAA)",Xenobiotics,"Synthesis of PC","Biosynthesis of DPAn-3 SPMs","Activation of caspases 
through apoptosome-mediated cleavage","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","TP53 Regulates Transcription of Caspase Activators and Caspases","Aromatic a
mines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of DPAn-3-derived protectins and resolvins"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{92-61-5,92615,"Gelseminic acid",7-Hydroxy-6-methoxy-2H-chromen-2-one,7Hydroxy6methoxy2Hchromen2one,6-Methylesculetin,6Methylesculetin,"Chrysatropic acid",7-Hydroxy-6-methoxycoumarin,7Hydroxy6methoxyc
oumarin,Murrayetin,Scopoletine,Scopoletol,Escopoletin,"2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy-","2H1Benzopyran2one, 7hydroxy6methoxy",6-O-Methyles,6OMethyles,T2984,1502242,Scopoletin,SCOPOLETIN}

> <pdid>
PD001341

> <targets>
{"Immunology & Inflammation related"}

> <classes>
{anticoagulant,"NO synthesis (inducible) inhibitor"}

> <pubchem_cids>
{5280460}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 46  0  0  0  0            999 V2000
    9.0707    5.2796    0.0000 C   0  0
    7.7691    6.0251    0.0000 O   0  0
    9.0758    3.7795    0.0000 C   0  0
   10.3776    3.0341    0.0000 C   0  0
   11.6740    3.7886    0.0000 C   0  0
   11.6688    5.2886    0.0000 C   0  0
   10.3671    6.0341    0.0000 N   0  0
   10.3619    7.5348    0.0000 C   0  0
   11.6571    8.2915    0.0000 C   0  0
   11.6495    9.7915    0.0000 C   0  0
   10.3467   10.5349    0.0000 C   0  0
    9.0515    9.7783    0.0000 C   0  0
    9.0591    8.2783    0.0000 C   0  0
   10.3391   12.0349    0.0000 F   0  0
   12.9652    6.0431    0.0000 C   0  0
    7.7802    3.0220    0.0000 C   0  0
    6.4773    3.7652    0.0000 O   0  0
    7.7876    1.5211    0.0000 N   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2122   -3.8625    0.0000 C   0  0
   -0.7464   -5.2884    0.0000 N   0  0
    0.7536   -5.2860    0.0000 N   0  0
    1.2149   -3.8587    0.0000 C   0  0
   -3.8805    1.4409    0.0000 C   0  0
    5.2059   -2.9909    0.0000 F   0  0
  1  2  2  0
  1  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  1  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
  6 15  1  0
  3 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 22 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  1  0
 32 28  2  0
 32 33  1  0
 33 34  2  0
 34 26  1  0
 34 35  1  0
 35 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  1  0
 39 35  2  0
 31 40  1  0
 21 41  1  0
M  END
> <name>
UTKinase_V5

> <id>
28745

> <plate>
Kinase v5-3

> <well>
C07

> <supplier_cmpd_name>
Merestinib (LY2801653)

> <ctcr_id>
12603

> <supplier_cmpd_id>
S7014

> <smiles>
c1(=O)c(ccc(n1c1ccc(cc1)F)C)C(=O)Nc1cc(c(cc1)Oc1cc2cnn(c2cc1c1cn[nH]c1)C)F

> <pd_targets>
{DDR1,MST1R,MKNK1,AXL,MET,MERTK,FLT3,TEK,TIE1,MKNK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CAMK protein kinase group","Tyrosine protein kinase DDR family","Tyrosine protein kinase Met family","CAMK protein kinase MAPKAPK family","Ty
rosine protein kinase Axl family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Tie family","CAMK protein kinase MNK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","TK: Tyrosine kinase","MAPK-Activated Protein Kinase (MAPKAPK) f
amily","Receptor tyrosine kinases (RTKs)","MKN subfamily","Type XVI RTKs: DDR (collagen receptor) family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XI RTKs: TAM (TYRO3-","AXL
- and MER-TK) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XII RTKs: TIE family of angiopoietin receptors"}

> <pathway_reactome>
{"Extracellular matrix organization","Signal Transduction","Developmental Biology",Hemostasis,"Non-integrin membrane-ECM interactions","Signaling by Receptor Tyrosine Kinases","Nervous system developm
ent","Cell surface interactions at the vascular wall","MAPK family signaling cascades","Signaling by MST1","Signaling by FGFR","Signaling by VEGF","Axon guidance","Signaling by Insulin receptor","MAPK
1/MAPK3 signaling","Signaling by FGFR4","VEGFA-VEGFR2 Pathway","Semaphorin interactions","Insulin receptor signalling cascade","RAF/MAP kinase cascade","Negative regulation of FGFR4 signaling","Sema4D
 in semaphorin signaling","IRS-mediated signalling","Spry regulation of FGF signaling","Sema4D mediated inhibition of cell attachment and migration","PI3K Cascade"}

> <broad_targets>
{MET}

> <broad_moa>
{"MET inhibitor"}

> <synonyms>
{Merestinib,LY2801653,1206799-15-6,1206799156,LY-2801653,UNII-5OGS5K699E,UNII5OGS5K699E,"Merestinib (LY2801653)",5OGS5K699E,"1206799-15-6 (free base)","1206799156 (free base)",C30H22F2N6O3,"Merestinib
 (USAN)",L1X,"Merestinib (USAN/INN)",SCHEMBL679002,"LY2801653 (Merestinib)",GTPL9841,CHEMBL35453,T3455}

> <pdid>
PD071468

> <targets>
{c-Met,Met,c-Met/HGFR,"Discoidin Domain Receptor",FLT3,ROS}

> <classes>
{Tyrosine Kinase/Adaptors,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{44603533}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  1  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6531   -3.1237    0.0000 S   0  0
   -3.6607   -4.2349    0.0000 C   0  0
   -5.1519   -4.0729    0.0000 O   0  0
   -2.9152   -5.5365    0.0000 N   0  0
   -1.4469   -5.2297    0.0000 C   0  0
   -0.3297   -6.2307    0.0000 O   0  0
    2.5987    1.5004    0.0000 C   0  0
    3.8991    0.7525    0.0000 C   0  0
    5.1969    1.5046    0.0000 C   0  0
    5.1945    3.0046    0.0000 C   0  0
    3.8943    3.7525    0.0000 C   0  0
    2.5964    3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0  2  0  0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8919   -5.2525    0.0000 N   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13  8  1  0
 13 14  2  0
  2 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
  1 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 25 27  1  1
M  END
> <name>
UTKinase_V5

> <id>
28746

> <plate>
Kinase v5-3

> <well>
C09

> <supplier_cmpd_name>
AZD1208

> <ctcr_id>
11440

> <supplier_cmpd_id>
S7104

> <smiles>
c1(c(cccc1/C=C/1\SC(=O)NC1=O)c1ccccc1)N1CCC[C@H](C1)N

> <pd_targets>
{PIM1,PIM3,PIM2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase PIM family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","PIM family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","FLT3 signaling in disease","Signaling by FLT3 ITD and TKD mutants","STAT5 activation downstream of FLT3 ITD
 mutants"}

> <broad_targets>
{PIM1,PIM2,PIM3}

> <broad_moa>
{"Pim kinase inhibitor"}

> <synonyms>
{AZD1208,1204144-28-4,1204144284,AZD-1208,UNII-S98NFM1378,UNIIS98NFM1378,CHEMBL2048872,S98NFM1378,"AZD 1208",GTPL7698,SCHEMBL1580644,AOB87151,EX-A1804,EXA1804,2236AH,BDBM50387298,MFCD25976757,NSC77606
6,NSC799343,s7104,ZINC84670255,AKOS025404917,CCG-268400,CCG268400,CS-1668,CS1668,NSC-776066,NSC-799,NSC799,T2300}

> <pdid>
PD010621

> <targets>
{Pim,Pim1,Pim2,Pim3,Apoptosis,Autophagy}

> <classes>
{Chromatin/Epigenetic,JAK/STAT signaling,Apoptosis,Autophagy,JAK/STAT Signaling}

> <pubchem_cids>
{58423153}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 42  0  0  0  0            999 V2000
    3.9068   -0.7607    0.0000 C   0  0
    2.6046   -1.5052    0.0000 O   0  0
    2.5973   -3.0060    0.0000 C   0  0
    3.8942   -3.7597    0.0000 C   0  0
    3.8899   -5.2597    0.0000 C   0  0
    5.1860   -6.0165    0.0000 N   0  0
    5.1795   -7.5173    0.0000 C   0  0
    6.2338   -8.5330    0.0000 C   0  0
    5.1664   -9.5869    0.0000 N   0  0
    5.1537  -11.0815    0.0000 C   0  0
    3.8482  -11.8218    0.0000 C   0  0
    3.8355  -13.3217    0.0000 F   0  0
    4.1125   -8.5195    0.0000 C   0  0
    2.5887   -6.0060    0.0000 C   0  0
    1.2918   -5.2523    0.0000 C   0  0
    1.2961   -3.7523    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 N   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -5.1977   -2.9829    0.0000 N   0  0
   -5.1903   -1.4821    0.0000 C   0  0
   -6.4841   -0.7230    0.0000 C   0  0
   -6.4738    0.7769    0.0000 C   0  0
   -5.1696    1.5179    0.0000 C   0  0
   -3.8758    0.7590    0.0000 C   0  0
   -2.5693    1.4977    0.0000 N   0  0
   -1.2759    0.7365    0.0000 C   0  0
   -1.2888   -0.7634    0.0000 O   0  0
    0.0306    1.4752    0.0000 C   0  0
    1.3233    0.7144    0.0000 C   0  0
   -3.8861   -0.7410    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 N   0  0
   -5.2096   -5.9864    0.0000 C   0  0
   -5.2157   -7.4863    0.0000 F   0  0
   -6.5058   -5.2315    0.0000 F   0  0
   -6.5115   -6.7312    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
  9 13  1  0
 13  7  1  0
  5 14  2  0
 14 15  1  0
 15 16  2  0
 16  3  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  2  0
 28 34  2  0
 34 24  1  0
 22 35  2  0
 35 18  1  0
 21 36  1  0
 36 37  1  0
 36 38  1  0
 36 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28747

> <plate>
Kinase v5-3

> <well>
C11

> <supplier_cmpd_name>
CNX-2006

> <ctcr_id>
3408

> <supplier_cmpd_id>
S7206

> <smiles>
COc1cc(NC2CN(CCF)C2)ccc1Nc3ncc(c(Nc4cccc(NC(=O)C=C)c4)n3)C(F)(F)F

> <pd_targets>
{EGFR,ERBB2,ERBB3,ERBB4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by GPCR","GPCR downstream signalling","G alpha (q) signalling events","Gastrin-CREB signalling pathway via PKC and MAPK","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{NX200,CNX-2006,CNX2006,1375465-09-0,1375465090,cnx2006,SCHEMBL7606842,CHEMBL3985592,C26H27F4N7O2,BDBM238270,HMS3653K17,AOB87152,BCP08863,EX-A1048,EXA1048,2332AH,MFCD26142654,s7206,AKOS027422744,ZINC1
02241092,CCG-269980,CCG269980,SB19367,NCGC00386271-01,NCGC0038627101,NCGC00386271-03,NCGC0038627103,AC-32831,AC32831,DA-45527,DA45527,HY,T6008,S7206}

> <pdid>
PD010393

> <targets>
{EGFR}

> <classes>
{}

> <pubchem_cids>
{56968072}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    3.8933   -3.7570    0.0000 C   0  0
    5.1937   -3.0093    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    5.1876   -6.0124    0.0000 C   0  0
    5.1824   -7.5124    0.0000 C   0  0
    3.8808   -8.2579    0.0000 N   0  0
    2.5844   -7.5034    0.0000 C   0  0
    2.5895   -6.0034    0.0000 C   0  0
  1  2  2  0
  1  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  8 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  7  1  0
  1 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28748

> <plate>
Kinase v5-3

> <well>
C13

> <supplier_cmpd_name>
PFK15

> <ctcr_id>
11733

> <supplier_cmpd_id>
S7289

> <smiles>
C(=O)(/C=C/c1nc2c(cc1)cccc2)c1ccncc1

> <pd_targets>
{PFKFB3}

> <pathway_gtopdb>
{Enzyme}

> <pathway_chembl>
{Enzymes,Phosphatases,"Sugar phosphatases"}

> <pathway_reactome>
{Metabolism,"Metabolism of carbohydrates","Glucose metabolism",Glycolysis,"Regulation of glycolysis by fructose 2","6-bisphosphate metabolism"}

> <broad_targets>
{PFKFB3}

> <broad_moa>
{"phosphofructokinase inhibitor"}

> <synonyms>
{FK01,PFK-015,PFK015,4382-63-2,4382632,PFK15,1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one,1(Pyridin4yl)3(quinolin2yl)prop2en1one,CHEMBL3105836,(E)-1-pyridin-4-yl-3-quinolin-2-ylprop-2-en-1-one,(E
)1pyridin4yl3quinolin2ylprop2en1one,1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one,1(4Pyridinyl)3(2quinolinyl)2propen1one,"PFK 15",SCHEMBL2702934,SCHEMBL16534534,AOB4632,SYN521,T2455}

> <pdid>
PD010364

> <targets>
{Autophagy,PFKFB3}

> <classes>
{Metabolism,Autophagy}

> <pubchem_cids>
{25142799}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 25  0  0  0  0            999 V2000
    5.2311   -3.4009    0.0000 C   0  0
    3.8056   -3.8679    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    1.8372   -5.2877    0.0000 N   0  0
    1.3786   -3.8595    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0031    0.0000 C   0  0
   -2.5988    1.5004    0.0000 C   0  0
   -2.5998    3.0004    0.0000 F   0  0
   -3.8976    0.7500    0.0000 F   0  0
   -3.8982    2.2498    0.0000 F   0  0
    0.9523   -6.4967    0.0000 C   0  0
   -0.5389   -6.3343    0.0000 C   0  0
    0.0659   -7.7068    0.0000 C   0  0
    1.5571   -7.8703    0.0000 C   0  0
    2.1616   -9.2431    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 12 14  1  0
 14 15  1  0
 11 16  1  0
 16 17  1  0
 16 18  1  0
 16 19  1  0
  4 20  1  0
 20 21  1  0
 20 22  1  0
 20 23  1  0
 23 24  3  0
M  END
> <name>
UTKinase_V5

> <id>
28749

> <plate>
Kinase v5-3

> <well>
C15

> <supplier_cmpd_name>
GNE-0877

> <ctcr_id>
11483

> <supplier_cmpd_id>
S7367

> <smiles>
Cc1nn(cc1Nc1ncc(c(n1)NC)C(F)(F)F)C(C)(C)C#N

> <pd_targets>
{LRRK2,TTK,CYP1A2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 1","TKL protein kinase group","Other protein kinase group","Cytochrome P450 family 1A","TKL protein kinase LRRK family","Other
 protein kinase TTK family","Cytochrome P450 1A1"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Cytochrome P450","Receptor kinases","CYP1 family","TKL: Tyrosine kinase-like","Other protein kinases","Leucine-rich repeat kinase (LRRK) family","TTK family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,"Signaling by Non-Receptor Tyrosine Kinases","Biological oxidations","Signaling by PTK6","Phase I - Functionalization of compounds","PTK6 promotes HIF1A stabilization
","Cytochrome P450 - arranged by substrate type",Xenobiotics,"Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NE087,GNE-0877,GNE0877,1374828-69-9,1374828699,UNII-ANGHS285FG,UNIIANGHS285FG,ANGHS285FG,CHEMBL3122113,GTPL9393,SCHEMBL4561063,C14H16F3N7,HMS3653E18,AMY16361,AOB87141,BCP09654,EX-A2062,EXA2062,"GNE 0
877",2434AH,BDBM50448118,MFCD28098661,s7367,AKOS027250747,ZINC103260600,CCG-267909,CCG267909,SB17,T6031}

> <pdid>
PD010334

> <targets>
{LRRK2}

> <classes>
{Autophagy}

> <pubchem_cids>
{69093374}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 46  0  0  0  0            999 V2000
    5.2120    3.6341    0.0000 C   0  0
    6.0996    2.4249    0.0000 N   0  0
    7.5906    2.5895    0.0000 C   0  0
    5.4979    1.0528    0.0000 C   0  0
    6.2524   -0.2436    0.0000 C   0  0
    5.2526   -1.3618    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    4.0317    0.7359    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2986   -3.7517    0.0000 F   0  0
    1.2993   -3.7504    0.0000 F   0  0
    0.0007   -4.5008    0.0000 F   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -7.7985    2.9932    0.0000 C   0  0
   -9.0976    3.7432    0.0000 C   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -6.4965    5.2441    0.0000 N   0  0
   -5.1957    5.9927    0.0000 C   0  0
   -5.1904    7.4927    0.0000 N   0  0
   -3.8888    8.2382    0.0000 C   0  0
   -2.5924    7.4838    0.0000 C   0  0
   -2.5975    5.9838    0.0000 C   0  0
   -3.8991    5.2382    0.0000 N   0  0
   -1.2901    8.2297    0.0000 C   0  0
   -1.2825    9.7297    0.0000 C   0  0
    0.0203   10.4732    0.0000 N   0  0
    1.3156    9.7167    0.0000 C   0  0
    1.3080    8.2167    0.0000 N   0  0
    0.0053    7.4732    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  4  1  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 15 16  1  0
 16 17  1  0
 16 18  1  0
 16 19  1  0
 13 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
 33 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 39 40  1  0
 40 41  2  0
 41 36  1  0
 28 42  2  0
 42 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28751

> <plate>
Kinase v5-3

> <well>
F06

> <supplier_cmpd_name>
Bafetinib (INNO-406)

> <ctcr_id>
5571

> <supplier_cmpd_id>
S1369

> <smiles>
CN(C)C1CCN(C1)Cc2ccc(cc2C(F)(F)F)C(=O)Nc3ccc(C)c(Nc4ncc(cn4)c5cncnc5)c3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{INNO-406;NS-187,INNO406;NS187,"Bafetinib (INNO-406)","Bafetinib (INNO406)",CHEMBL4303396,NCGC00389331-01,NCGC0038933101,AK-64388,AK64388,FT-0774043,FT0774043,S1369}

> <pdid>
PD021634

> <targets>
{Bcr-Abl}

> <classes>
{}

> <pubchem_cids>
{74333653}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    2.5795   -7.5040    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 O   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 Br  0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -2.5764   -7.5048    0.0000 O   0  0
   -1.2730   -8.2489    0.0000 C   0  0
   -1.2625   -9.7489    0.0000 C   0  0
    0.0417  -10.4898    0.0000 C   0  0
    1.3355   -9.7309    0.0000 C   0  0
    1.3251   -8.2309    0.0000 C   0  0
    0.0209   -7.4899    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  3
 17 11  1  0
 17 18  1  0
 12 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  3
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  1  0
 26 27  2  3
 27 28  1  0
 28 29  2  3
 29 30  1  0
 30 31  2  3
 31 26  1  0
 24 32  1  0
 32 33  2  3
 33 21  1  0
 19 34  2  3
 34  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28752

> <plate>
Kinase v5-3

> <well>
E19

> <supplier_cmpd_name>
G-749

> <ctcr_id>
11448

> <supplier_cmpd_id>
S7545

> <smiles>
CN1CCC(CC1)NC1=NC2=C(C(=O)NC=C2Br)C(NC2=CC=C(OC3=CC=CC=C3)C=C2)=N1

> <pd_targets>
{MERTK,FLT3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Axl family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type III RTKs: PDGFR",CSFR,
Kit,"FLT3 receptor family"}

> <pathway_reactome>
{Hemostasis,"Signal Transduction","Cell surface interactions at the vascular wall","Signaling by Receptor Tyrosine Kinases","Signaling by Insulin receptor","Insulin receptor signalling cascade","IRS-m
ediated signalling","PI3K Cascade"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{74,G-749,G749,1457983-28-6,1457983286,UNII-B06W426B66,UNIIB06W426B66,B06W426B66,C25H25BrN6O2,GTPL8108,CHEMBL4544478,SCHEMBL15265027,AOB87764,BCP11201,EX-A1074,EXA1074,2183AH,MFCD28167815,s7545,ZINC95
644293,AKOS026750566,CCG-269863,CCG269863,CS-3343,CS3343,NCGC00386412-04,NCGC0038641204,AC-33000,AC33000,BS-15433,BS15433,DA-33613,DA33613,HY-1,HY1,T2620}

> <pdid>
PD021556

> <targets>
{FLT3,"Aurora B",RET,"FLT3 (D835Y)",Mer}

> <classes>
{"Cell Cycle/Checkpoint",Angiogenesis,Apoptosis,"Tyrosine Kinase/Adaptors",Chromatin/Epigenetic}

> <pubchem_cids>
{78357765}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.5532   -4.4223    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
    0.6929   -4.0817    0.0000 C   0  0
    2.1742   -4.0242    0.0000 C   0  0
    2.6753   -5.4380    0.0000 C   0  0
    4.1136   -5.8636    0.0000 O   0  0
    1.4855   -6.3514    0.0000 N   0  0
    0.2491   -5.5022    0.0000 C   0  0
   -1.1685   -5.9926    0.0000 O   0  0
    1.5252   -7.8509    0.0000 C   0  0
    3.0145   -2.7838    0.0000 N   0  0
    4.5115   -2.8904    0.0000 C   0  0
    5.3531   -1.6477    0.0000 C   0  0
    6.8502   -1.7544    0.0000 C   0  0
    7.6932   -0.5136    0.0000 C   0  0
    9.1892   -0.6232    0.0000 C   0  0
    9.8423   -1.9736    0.0000 C   0  0
    8.9993   -3.2144    0.0000 C   0  0
    7.5034   -3.1048    0.0000 C   0  0
   11.3382   -2.0832    0.0000 F   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  8 10  1  0
 10  5  1  0
  7 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 11  1  0
 16 17  2  0
 15 18  1  0
 12 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 25 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28753

> <plate>
Kinase v5-3

> <well>
E21

> <supplier_cmpd_name>
IM-12

> <ctcr_id>
11416

> <supplier_cmpd_id>
S7566

> <smiles>
c1cccc2c1c(c(C)[nH]2)C1=C(C(=O)N(C1=O)C)NCCc1ccc(cc1)F

> <pd_targets>
{GSK3B}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase GSK family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Glycogen synthase kinase (GSK) family","GSK subfamily"}

> <pathway_reactome>
{Disease,"Infectious disease","SARS-CoV Infections","SARS-CoV-1 Infection","SARS-CoV-1 Genome Replication and Transcription","Replication of the SARS-CoV-1 genome"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{M1,IM-12,IM12,1129669-05-1,1129669051,"IM 12",CHEMBL1254896,GTPL8017,SCHEMBL17378682,AOB4090,DTXSID20649091,CHEBI:125616,HMS3653F15,BCP10769,EX-A2071,EXA2071,2472AH,BDBM50326901,s7566,ZINC59086693,AK
OS026750397,CCG-208085,CCG208085,CS-3399,CS3399,SB19269,NCGC00386352-05,NCGC0038635205,AC-32946,AC32946,AK547017,AS-5,AS5,T2261}

> <pdid>
PD010278

> <targets>
{GSK-3,GSK-3¦Â}

> <classes>
{"PI3K/Akt/mTOR signaling","Stem Cells"}

> <pubchem_cids>
{25209788}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    3.8794   -1.4442    0.0000 C   0  0
    4.8823   -2.5608    0.0000 C   0  0
    4.5513   -4.0107    0.0000 C   0  0
    3.1755   -4.6084    0.0000 O   0  0
    5.8480   -4.7648    0.0000 N   0  0
    6.9651   -3.7649    0.0000 C   0  0
    8.4564   -3.9264    0.0000 C   0  0
    9.3418   -2.7156    0.0000 C   0  0
    8.7360   -1.3434    0.0000 C   0  0
    7.2447   -1.1820    0.0000 N   0  0
    6.3593   -2.3927    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21  2  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28754

> <plate>
Kinase v5-3

> <well>
E03

> <supplier_cmpd_name>
GW441756

> <ctcr_id>
7732

> <supplier_cmpd_id>
S2891

> <smiles>
Cn1cc(\C=C2/C(=O)Nc3cccnc23)c4ccccc14

> <pd_targets>
{FLT4,STK17A,MAP3K20,IRAK1,NEK4,CLK4,CSNK1A1,MAPK9,AURKA,MINK1,NTRK1,IRAK4,CAMK2G,FFP,CHEK2,IGF1R,RET,KMT2A,MEN1,PRKD2,SGK2,MARK2,ALK,LCK,CDK5,CLK2,MAP4K4,PHKG2,PIM1,PIM3,DYRK1A,MAP4K2,CSNK1D,NTRK2,NT
RK3,PKN2,MAP4K5,MAPT,RPS6KA3,BRSK1,INSR,LYN,SYK,ROCK1,PRKAA1,ITK,KDR,CDK1,AURKB,HIPK2,HIPK4,NEK2,STK3,PRKD3,ROCK2,MARK3,FER,FRK,SRC,GSK3B,SLK,BLK,FGFR1,CDK2,CSNK2A1,RPS6KB1,CAMK2D}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein",Kinase,Transferase,Reader,"Protein Kinase",Bromodomain,"TK protein kinase group","CAMK protein kinase group","TKL protein kinase group","Other 
protein kinase group","CMGC protein kinase group","CK1 protein kinase group","STE protein kinase group","AGC protein kinase group","Tyrosine protein kinase VEGFR family","CAMK protein kinase DAPK fami
ly","TKL protein kinase MLK family","TKL protein kinase IRAK family","Other protein kinase NEK family","CMGC protein kinase CLK family","CK1 protein kinase CK1 family","CMGC protein kinase MAPK family
","Other protein kinase AUR family","STE protein kinase STE20 family","Tyrosine protein kinase Trk family","CAMK protein kinase CAMK2 family","CAMK protein kinase RAD53 family","Tyrosine protein kinas
e InsR family","Tyrosine protein kinase Ret family","CAMK protein kinase PKD family","AGC protein kinase SGK family","CAMK protein kinase CAMK1 family","TKL protein kinase STKR family","Tyrosine prote
in kinase Src family","CMGC protein kinase CDK family","CAMK protein kinase PHk family","CAMK protein kinase PIM family","CMGC protein kinase DYRK family","AGC protein kinase PKN family","AGC protein 
kinase RSK family","Tyrosine protein kinase Syk family","AGC protein kinase DMPK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Fer family","CMGC protein kinase GSK family","Tyr
osine protein kinase FGFR family","Other protein kinase CK2 family","TKL protein kinase MLK subfamily","CMGC protein kinase JNK subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MARK 
subfamily","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase Dyrk1 subfamily","STE protein kinase KHS subfamily","AGC protein kinase RSK subfamily","
CAMK protein kinase BRSK subfamily","AGC protein kinase ROCK subfamily","CAMK protein kinase AMPK subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase HIPK subfamily","STE protein kina
se MST subfamily","STE protein kinase SLK subfamily","AGC protein kinase p70 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kin
ase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","TK: Tyrosine kinase","Death-associated kinase (DAPK) family","TKL: Tyrosine kinase
-like","Other protein kinases","CLK family","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","STE20 family","CAMK2 family","CAMK-like (CAMKL) family","Protein kinase D 
(PKD) family","SGK family","Cyclin-dependent kinase (CDK) family","Phosphorylase kinase (PHK) family","PIM family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Prote
in kinase N (PKN) family","RSK family","DMPK family","Glycogen synthase kinase (GSK) family","Receptor tyrosine kinases (RTKs)","Mixed Lineage Kinase (MLK) family","Interleukin-1 receptor-associated k
inase (IRAK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","JNK subfamily","Aurora kinase (Aur) family","MSN subfamily","CHK1 subfamily","MARK subfamily","Non-receptor tyrosine
 kinases (nRTKs)","CDK5 subfamily","Dyrk1 subfamily","KHS subfamily","RSK subfamily","BRSK subfamily","Rho kinase","AMPK subfamily","CDK1 subfamily","HIPK subfamily","MST subfamily","GSK subfamily","S
LK subfamily","Casein kinase 2 (CK2) family","p70 subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","MLK subfamily","Type VII RTKs: Neurotrophin receptor/Trk family"
,"Type II RTKs: Insulin receptor family","Type XIV RTKs: RET","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Src family","Syk family","Tec family","Fer family","Type V RTKs: FGF (fi
broblast growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Disease,"Gene expression (Transcription)","Cellular responses to external stimuli","Neuronal System","Developmental Biology",Metabolism,"Transport of small molec
ules","Cell Cycle","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription",
"Cellular responses to stress","Transmission across Chemical Synapses","Nervous system development","Metabolism of lipids","Ion channel transport","Infectious disease","Metabolism of carbohydrates",Mi
totic,"Signaling by Rho GTPases","Intracellular signaling by second messengers","Adaptive Immune System","Signaling by Hippo","MTOR signalling","Signaling by VEGF","Toll-like Receptor Cascades","Signa
ling by WNT in cancer","Generic Transcription Pathway","Cellular Senescence","Signaling by NTRKs","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by Type 1 Insulin-like Gr
owth Factor 1 Receptor (IGF1R)","Axon guidance","Sphingolipid metabolism","Stimuli-sensing channels","HIV Infection","Glycogen metabolism","FLT3 signaling in disease","Mitotic G1 phase and G1/S transi
tion","Mitotic G2-G2/M phases","RHO GTPase Effectors","PIP3 activates AKT signaling","Leishmania infection","TCR signaling","Regulation of mitotic cell cycle","M Phase","Oncogenic MAPK signaling","Sig
naling by SCF-KIT","SARS-CoV Infections","Signaling by FGFR in disease","mTORC1-mediated signalling","VEGF ligand-receptor interactions","Toll Like Receptor 5 (TLR5) Cascade","Signaling by AMER1 mutan
ts","Transcriptional Regulation by TP53","Oxidative Stress Induced Senescence","Signaling by NTRK1 (TRKA)","Toll Like Receptor 2 (TLR2) Cascade","Activation of NMDA receptors and postsynaptic events",
"IGF1R signaling cascade","RET signaling","Sphingolipid de novo biosynthesis","Host Interactions of HIV factors","Glycogen breakdown (glycogenolysis)","Signaling by FLT3 ITD and TKD mutants","G0 and E
arly G1","G2/M Transition","Signaling by NTRK3 (TRKC)","RHO GTPases activate PKNs","Negative regulation of the PI3K/AKT network","Leishmania parasite growth and survival","Semaphorin interactions","Ge
neration of second messenger molecules","VEGFA-VEGFR2 Pathway","APC/C-mediated degradation of cell cycle proteins","Mitotic Metaphase and Anaphase","Signaling by RAS mutants","PTEN Regulation","SARS-C
oV-1 Infection","Transcriptional regulation by RUNX1","Signaling by FGFR1 in disease","VEGF binds to VEGFR leading to receptor dimerization","MyD88 cascade initiated on plasma membrane","Truncations o
f AMER1 destabilize the destruction complex","Regulation of TP53 Activity","Signalling to ERKs","Toll Like Receptor TLR6:TLR2 Cascade","Post NMDA receptor activation events","IRS-related events trigge
red by IGF1R","The role of Nef in HIV-1 replication and disease pathogenesis","STAT5 activation downstream of FLT3 ITD mutants","Centrosome maturation","Activation of TRKA receptors","Activated NTRK3 
signals through PI3K",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Anti-inflammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","VEGFR2 mediated cell proli
feration","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Mitotic Anaphase","Signaling downstream of RAS mutants","Regulation of PTEN stability and activity","SARS-CoV-
1 Genome Replication and Transcription","RUNX1 regulates transcription of genes involved in BCR signaling","FGFR1 mutant receptor activation","MAP kinase activation","Regulation of TP53 Activity throu
gh Phosphorylation","Prolonged ERK activation events","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Regula
tion of TP53 Expression and Degradation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Loss of proteins required for interphase microtubule organiza
tion from the centrosome","NGF-independant TRKA activation","Activation of AMPK downstream of NMDARs","FCGR3A-mediated IL10 synthesis","Sema4D induced cell migration and growth-cone collapse","APC/C:C
dc20 mediated degradation of mitotic proteins","Separation of Sister Chromatids","Signalling to RAS","Replication of the SARS-CoV-1 genome","Signaling by activated point mutants of FGFR1","activated T
AK1 mediates p38 MAPK activation","MAPK targets/ Nuclear events mediated by MAP kinases","ARMS-mediated activation","Ras activation upon Ca2+ influx through NMDA receptor","Regulation of TP53 Degradat
ion","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","p38MAPK events
","Activation of the AP-1 family of transcription factors","CREB phosphorylation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","APC-Cdc20 mediated degradation of Nek2A"}

> <broad_targets>
{NTRK1}

> <broad_moa>
{"growth factor receptor inhibitor"}

> <synonyms>
{"GW 441756",504433-23-2,504433232,GW441756,GW-441756,CHEMBL176544,"(3Z)-3-((1-methylindol-3-yl)methylidene)-1H-pyrrolo(3,2-b)pyridin-2-one","(3Z)3((1methylindol3yl)methylidene)1Hpyrrolo(3,2b)pyridin2
one",C17H13N3O,QCR-77,QCR77,SCHEMBL5787769,CHEBI:92072,SYN1044,HMS3303P17,HMS3305D02,HMS3884D22,504433-24-3,504433243,EX-A1842,EXA1842,ZINC398,SY-GW441756}

> <pdid>
PD003852

> <targets>
{"Trk receptor"}

> <classes>
{}

> <pubchem_cids>
{9943465}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  1  0            999 V2000
    6.0235   -5.4004    0.0000 C   0  0  1  0  0  0
    6.5240   -3.9863    0.0000 C   0  0  1  0  0  0
    7.9988   -3.7126    0.0000 C   0  0  2  0  0  0
    8.9732   -4.8530    0.0000 C   0  0  1  0  0  0
    8.4729   -6.2671    0.0000 C   0  0  2  0  0  0
    6.9981   -6.5408    0.0000 O   0  0
    9.4502   -7.4061    0.0000 C   0  0
   10.9246   -7.1303    0.0000 O   0  0
   10.4481   -4.5793    0.0000 O   0  0
    8.4992   -2.2985    0.0000 O   0  0
    5.5496   -2.8459    0.0000 O   0  0
    4.5473   -5.6713    0.0000 O   0  0
    3.5740   -4.5289    0.0000 C   0  0
    2.0982   -4.7975    0.0000 C   0  0
    1.1277   -3.6538    0.0000 C   0  0
    1.6321   -2.2464    0.0000 C   0  0
    3.1087   -1.9728    0.0000 C   0  0
    4.0792   -3.1166    0.0000 C   0  0
    0.7500   -1.0323    0.0000 C   0  0  1  0  0  0
    1.2135    0.3943    0.0000 O   0  0
    0.0000    1.2760    0.0000 C   0  0
   -1.2135    0.3943    0.0000 C   0  0  1  0  0  0
   -0.7500   -1.0323    0.0000 C   0  0  2  0  0  0
   -1.9615   -1.9133    0.0000 C   0  0
   -3.1750   -1.0316    0.0000 O   0  0
   -2.7115    0.3949    0.0000 C   0  0  1  0  0  0
   -3.5934    1.6093    0.0000 C   0  0
   -3.0889    3.0166    0.0000 C   0  0
   -4.0593    4.1604    0.0000 C   0  0
   -5.5351    3.8919    0.0000 C   0  0
   -6.0404    2.4796    0.0000 C   0  0
   -5.0700    1.3358    0.0000 C   0  0
   -6.5084    5.0343    0.0000 O   0  0
   -7.9838    4.7637    0.0000 C   0  0
   -3.5508    5.5724    0.0000 O   0  0
   -2.0746    5.8389    0.0000 C   0  0
    1.5897   -6.2096    0.0000 O   0  0
    0.1136   -6.4761    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  5  7  1  1
  7  8  1  0
  4  9  1  6
  3 10  1  1
  2 11  1  6
  1 12  1  1
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 19 16  1  6
 19 20  1  0
 20 21  1  0
 22 21  1  1
 22 23  1  0
 23 19  1  0
 23 24  1  1
 24 25  1  0
 25 26  1  0
 26 22  1  0
 26 27  1  1
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 30 33  1  0
 33 34  1  0
 29 35  1  0
 35 36  1  0
 14 37  1  0
 37 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28755

> <plate>
Kinase v5-3

> <well>
E05

> <supplier_cmpd_name>
Forsythin

> <ctcr_id>
11175

> <supplier_cmpd_id>
S3926

> <smiles>
[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)Oc1c(cc(cc1)[C@H]1OC[C@H]2[C@@H]1CO[C@H]2c1cc(c(cc1)OC)OC)OC

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{UNII-VE9P4964MG,UNIIVE9P4964MG,VE9P4964MG,SCHEMBL710957,"Phillyrin, >=98 (HPLC)",CHEBI:80888,DTXSID40197589,HY-N0482,HYN0482,s3926,ZINC56874329,AKOS037514776,CCG-269935,CCG269935,CS-0009002,CS0009002
,C17048,Q27151384,T2854,Forsythin}

> <pdid>
PD011948

> <targets>
{Others,AMPK}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{101712}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  1  0            999 V2000
    1.2948   -3.7516    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1950   -3.0115    0.0000 C   0  0
    6.4915   -3.7659    0.0000 C   0  0
    6.4864   -5.2659    0.0000 N   0  0
    5.1848   -6.0115    0.0000 C   0  0
    3.8883   -5.2570    0.0000 C   0  0
    2.5867   -6.0026    0.0000 Cl  0  0
    5.2002   -1.5115    0.0000 Cl  0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -0.3115    2.9665    0.0000 C   0  0
    0.6890    4.0818    0.0000 C   0  0
    0.2234    5.5086    0.0000 C   0  0
    1.2256    6.6258    0.0000 C   0  0
    0.8993    8.0768    0.0000 C   0  0
    2.1985    8.8266    0.0000 N   0  0
    3.3130    7.8227    0.0000 N   0  0
    2.7027    6.4525    0.0000 C   0  0
    2.3585   10.3163    0.0000 C   0  0
    3.7305   10.9245    0.0000 C   0  0
    3.8907   12.4159    0.0000 O   0  0
  2  1  1  1
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  4 10  1  0
  2 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  1  0
 19 20  2  0
 20 14  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 23  1  0
 25 28  1  0
 28 29  1  0
 29 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28756

> <plate>
Kinase v5-3

> <well>
E07

> <supplier_cmpd_name>
LY2874455

> <ctcr_id>
12164

> <supplier_cmpd_id>
S7057

> <smiles>
C[C@H](c1c(cncc1Cl)Cl)Oc1cc2c(cc1)[nH]nc2/C=C/c1cn(nc1)CCO

> <pd_targets>
{KDR,FGFR2,FGFR4,FGFR1,FGFR3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase FGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type V RTKs: FGF
 (fibroblast growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by VEGF","Signaling by FGFR in dis
ease","Signaling by FGFR","VEGFA-VEGFR2 Pathway","Signaling by FGFR2 in disease","Signaling by FGFR4","Signaling by FGFR1 in disease","Signaling by FGFR3 in disease","VEGFR2 mediated cell proliferatio
n","FGFR2 mutant receptor activation","Downstream signaling of activated FGFR4","FGFR1 mutant receptor activation","Signaling by FGFR3 point mutants in cancer","Activated point mutants of FGFR2","FRS-
mediated FGFR4 signaling","Signaling by activated point mutants of FGFR1","FGFR3 mutant receptor activation","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Y287445,LY2874455,1254473-64-7,1254473647,LY-2874455,UNII-E9M363811V,UNIIE9M363811V,CHEMBL3828009,"LY 2874455",E9M363811V,C21H19Cl2N5O2,"LY2874455 monohydrate",SCHEMBL298445,SCHEMBL298446,GTPL8104,QC
R-90,QCR90,DTXSID20154776,BCP04756,EX-A1340,EXA1340,2529AH,BDBM50189781,NSC771750,NSC783670,s,T2361}

> <pdid>
PD012905

> <targets>
{FGFR,VEGFR,FGFR1,FGFR2,FGFR3,FGFR4,VEGFR2}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{46944259}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 34  0  0  0  0            999 V2000
    3.8805   -1.4410    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4135   -4.4923    0.0000 C   0  0
    3.8394   -4.9554    0.0000 N   0  0
    5.0531   -4.0770    0.0000 C   0  0
    6.4235   -4.6892    0.0000 C   0  0
    7.6393   -3.8093    0.0000 C   0  0
    8.8545   -2.9299    0.0000 N   0  0
    3.8394   -6.4554    0.0000 C   0  0
    4.9537   -7.4579    0.0000 C   0  0
    4.6418   -8.9251    0.0000 C   0  0
    3.2152   -9.3886    0.0000 C   0  0
    2.1005   -8.3849    0.0000 C   0  0
    2.4128   -6.9189    0.0000 C   0  0
    1.5318   -5.7059    0.0000 C   0  0
    0.0400   -5.5491    0.0000 C   0  0
   -1.0739   -6.5524    0.0000 C   0  0
   -2.3730   -5.8024    0.0000 N   0  0
   -2.0611   -4.3352    0.0000 C   0  0
   -3.0647   -3.2204    0.0000 O   0  0
   -0.5701   -4.1788    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  3  0
 12 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 22 23  1  0
 23 11  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 27 29  1  0
 29  9  1  0
 29 24  2  0
M  END
> <name>
UTKinase_V5

> <id>
28757

> <plate>
Kinase v5-3

> <well>
E09

> <supplier_cmpd_name>
Go6976

> <ctcr_id>
1798

> <supplier_cmpd_id>
S7119

> <smiles>
Cn1c2ccccc2c3c1c4n(CCC#N)c5ccccc5c4c6CNC(=O)c36

> <pd_targets>
{MARK3,GSK3A,MAPK1,PRKCB,MYLK,PRKCA,PIM1,PLK4,CSF1R,LYN,BLK,ERBB2,CDK2,EGFR,CDK1,PRKCD,PRKCE,PRKCG,PRKCH,PRKCQ,PRKCZ,ROCK2,PRKD1,PRKG1,LCK,KDR,MAPK8,MARK2,PAK4,PDPK1,RPS6KB1,FLT3,RPS6KA3,ITK,PRKACA,CH
EK2,DYRK1A,GSK3B,LIMK1,AURKA,TYK2,JAK3,ROCK1,MAPK9,PRKD2,FGFR1,IRAK4,AURKB,IMPA1,CDK5,INSR,FLT4,FLT1}

> <pathway_gtopdb>
{Enzyme,Kinase,Hydrolase,"Protein Kinase","CAMK protein kinase group","CMGC protein kinase group","AGC protein kinase group","Other protein kinase group","TK protein kinase group","STE protein kinase 
group","TKL protein kinase group","CAMK protein kinase CAMK1 family","CMGC protein kinase GSK family","CMGC protein kinase MAPK family","AGC protein kinase PKC family","CAMK protein kinase MLCK family
","CAMK protein kinase PIM family","Other protein kinase PLK family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase EGFR family","CMGC protein kin
ase CDK family","AGC protein kinase DMPK family","CAMK protein kinase PKD family","AGC protein kinase PKG family","Tyrosine protein kinase VEGFR family","STE protein kinase STE20 family","AGC protein 
kinase PDK1 subfamily","AGC protein kinase RSK family","Tyrosine protein kinase Tec family","AGC protein kinase PKA family","CAMK protein kinase RAD53 family","CMGC protein kinase DYRK family","TKL pr
otein kinase LISK family","Other protein kinase AUR family","Tyrosine protein kinase JakA family","Tyrosine protein kinase FGFR family","TKL protein kinase IRAK family","Tyrosine protein kinase InsR f
amily","CAMK protein kinase MARK subfamily","CMGC protein kinase ERK1","AGC protein kinase PKC alpha subfamily","CMGC protein kinase CDC2 subfamily","AGC protein kinase ROCK subfamily","CMGC protein k
inase JNK subfamily","AGC protein kinase PKC delta subfamily","STE protein kinase PAKB subfamily","AGC protein kinase p70 subfamily","AGC protein kinase RSK subfamily","CMGC protein kinase Dyrk1 subfa
mily","TKL protein kinase LIMK subfamily","CMGC protein kinase CDK5 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Inositol phosphate turnover","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC:
 Containing PKA",PKG,"PKC families","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Inositol monophosphatase","CAMK-like (CAMKL) family","Glycogen synthase kin
ase (GSK) family","Mitogen-activated protein kinases (MAP kinases)","Protein kinase C (PKC) family","Myosin Light Chain Kinase (MLCK) family","PIM family","Other protein kinases","TK: Tyrosine kinase"
,"Cyclin-dependent kinase (CDK) family","DMPK family","Protein kinase D (PKD) family","Protein kinase G (PKG) family","STE20 family","PDK1 family","RSK family","Protein kinase A (PKA) family","Dual-sp
ecificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","TKL: Tyrosine kinase-like","MARK subfamily","GSK subfamily","ERK subfamily","Alpha subfamily","Delta subfamily","Polo-like kinas
e (PLK) family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","CDK1 subfamily","Rho kinase","JNK subfamily","PAKB subfamily","p70 subfamily","RSK subfamily","CHK1 subfamil
y","Dyrk1 subfamily","LIM domain kinase (LISK) family","Aurora kinase (Aur) family","Interleukin-1 receptor-associated kinase (IRAK) family","CDK5 subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 rece
ptor family","Src family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Tec family","LIMK subfamily","Janus k
inase (JakA) family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type II RTKs: Insulin receptor family"}

> <pathway_reactome>
{Disease,"Immune System","Cell Cycle","Signal Transduction","Gene expression (Transcription)","Developmental Biology",Metabolism,Hemostasis,"Neuronal System","Diseases of signal transduction by growth
 factor receptors and second messengers","Infectious disease","Innate Immune System",Mitotic,"Signaling by Rho GTPases","Signaling by GPCR","RNA Polymerase II Transcription","Nervous system developmen
t","Metabolism of lipids","Platelet homeostasis","Signaling by Receptor Tyrosine Kinases","Intracellular signaling by second messengers","Transmission across Chemical Synapses","MTOR signalling","Adap
tive Immune System","Cytokine Signaling in Immune system","Inositol phosphate metabolism","Oncogenic MAPK signaling","SARS-CoV Infections","Toll-like Receptor Cascades","M Phase","RHO GTPase Effectors
","GPCR downstream signalling","FLT3 signaling in disease","Mitotic G2-G2/M phases","Generic Transcription Pathway","Leishmania infection","Axon guidance","Regulation of mitotic cell cycle","Sphingoli
pid metabolism","Nitric oxide stimulates guanylate cyclase","HIV Infection","Signaling by VEGF","DAG and IP3 signaling","Neurotransmitter receptors and postsynaptic signal transmission","mTORC1-mediat
ed signalling","Signaling by Insulin receptor","TCR signaling","Mitotic G1 phase and G1/S transition","Interferon Signaling","Signaling by Interleukins","Signaling by FGFR in disease","Synthesis of IP
2",IP,"and Ins in the cytosol","PIP3 activates AKT signaling","Signaling by RAS mutants","SARS-CoV-1 Infection","Toll Like Receptor 5 (TLR5) Cascade","Mitotic Prophase","RHO GTPases activate PAKs","G 
alpha (i) signalling events","Signaling by FLT3 ITD and TKD mutants","G2/M Transition","Transcriptional Regulation by VENTX","Leishmania parasite growth and survival","Transcriptional regulation by RU
NX1","Semaphorin interactions","Transcriptional Regulation by TP53","G alpha (q) signalling events","APC/C-mediated degradation of cell cycle proteins","Sphingolipid de novo biosynthesis","cGMP effect
s","Host Interactions of HIV factors","VEGFA-VEGFR2 Pathway","CaM pathway","Glutamate binding","activation of AMPA receptors and synaptic plasticity","Signaling by ROBO receptors","Insulin receptor si
gnalling cascade","Generation of second messenger molecules","G0 and Early G1","Interferon alpha/beta signaling","Interleukin-2 family signaling","Signaling by FGFR1 in disease","Toll Like Receptor 2 
(TLR2) Cascade","Mitotic Metaphase and Anaphase","Negative regulation of the PI3K/AKT network","VEGF ligand-receptor interactions","Signaling downstream of RAS mutants","SARS-CoV-1 Genome Replication 
and Transcription","MyD88 cascade initiated on plasma membrane","Nuclear Envelope Breakdown","Visual phototransduction","STAT5 activation downstream of FLT3 ITD mutants","Centrosome maturation","Anti-
inflammatory response favouring Leishmania parasite infection","RUNX1 regulates transcription of genes involved in BCR signaling","Sema4D in semaphorin signaling","Regulation of TP53 Activity","Gastri
n-CREB signalling pathway via PKC and MAPK","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","The role of Nef in HIV-1 replication and disease pathogenesis","VEGFR2 media
ted cell proliferation","Calmodulin induced events","Trafficking of AMPA receptors","Activation of RAC1","IRS-mediated signalling","Regulation of IFNA signaling","Interleukin-15 signaling","FGFR1 muta
nt receptor activation","Toll Like Receptor TLR6:TLR2 Cascade","Mitotic Anaphase",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","VEGF binds to VEGFR leading to receptor dimerization","Replication o
f the SARS-CoV-1 genome","MAP kinase activation","Depolymerisation of the Nuclear Lamina","The phototransduction cascade","Loss of proteins required for interphase microtubule organization from the ce
ntrosome","FCGR3A-mediated IL10 synthesis","Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Expression and Degradation","EGFR Transactivation by Gastrin","APC/C:Cdc20 media
ted degradation of mitotic proteins","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Trafficking of GluR2-containing AMPA receptors","PI3K Cascade","R
egulation of TP53 Activity through Phosphorylation","Signaling by activated point mutants of FGFR1","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","Separation of Sister Chromatids","MAPK targ
ets/ Nuclear events mediated by MAP kinases",Inactivation,"recovery and regulation of the phototransduction cascade","Loss of Nlp from mitotic centrosomes","Regulation of TP53 Degradation","APC:Cdc20 
mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Nef Mediated CD4 Down-regulation","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated degradation of Cyclin
 A","Activation of the AP-1 family of transcription factors","CREB phosphorylation","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Go 6976",136194-77-9,136194779,GO6976,Go-6976,Go6976,"Goe 6976",UNII-B9IQO7JZ16,UNIIB9IQO7JZ16,B9IQO7JZ16,CHEMBL302449,C24H18N4O,CHEBI:51913,"G&ouml; 6976","Go 6976, Solution","InSolution&trade; G&o
uml; 6976",ACMC-20cqgs,ACMC20cqgs,Kinome_3630,Kinome3630,Kinome-3630,"Kinome 3630","Gouml 6976",CBiol_001871,CBiol001871,CBiol-001871,"CBiol 001871",BSPBio_001101,BSPBio001101,BSPBio-001101,"BSPBio 00
1101",KBi,"EMD 365250",365250}

> <pdid>
PD017321

> <targets>
{FLT3,JAK,PKC}

> <classes>
{}

> <pubchem_cids>
{3501}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2978    3.7529    0.0000 N   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 C   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -0.0103    7.5017    0.0000 C   0  0
    1.2863    8.2560    0.0000 O   0  0
   -1.3123    8.2482    0.0000 N   0  0
   -1.3178    9.7490    0.0000 C   0  0
   -2.6198   10.4955    0.0000 C   0  0
   -2.6252   11.9955    0.0000 C   0  0
   -3.9214   11.2409    0.0000 C   0  0
   -3.9163    9.7412    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -3.8976   -0.7554    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 N   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -4.5642   -5.0103    0.0000 C   0  0
   -5.3141   -3.7112    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  8 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 15 17  1  0
 15 18  1  0
  4 19  2  0
 19 20  1  0
 20 21  2  0
 21  2  1  0
 20 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 25  1  0
  3 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28758

> <plate>
Kinase v5-3

> <well>
E11

> <supplier_cmpd_name>
Losmapimod (GW856553X)

> <ctcr_id>
11418

> <supplier_cmpd_id>
S7215

> <smiles>
Fc1c(c(c2ncc(cc2)C(=O)NCC(C)(C)C)cc(c1)C(=O)NC1CC1)C

> <pd_targets>
{MAPK14,CYP2C9,MAPK11,MAPK13,MAPK12}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 2","CMGC protein kinase group","Cytochrome P450 family 2C","CMGC protein kinase MAPK family","Cytochrome P450 2C9","CMGC prote
in kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Cytochrome P450","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP2 family: drug metabolising subset","Mitogen-activated protein kinases (MAP kinases)","p38 subfami
ly"}

> <pathway_reactome>
{"Immune System",Metabolism,"Signal Transduction","Innate Immune System","Biological oxidations","Signaling by Receptor Tyrosine Kinases","Toll-like Receptor Cascades","Phase I - Functionalization of 
compounds","Signaling by NTRKs","Toll Like Receptor 5 (TLR5) Cascade","Cytochrome P450 - arranged by substrate type","Signaling by NTRK1 (TRKA)","MyD88 cascade initiated on plasma membrane",Xenobiotic
s,"Signalling to ERKs","MAP kinase activation","CYP2E1 reactions","Signalling to RAS","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","Activation of the AP-1 family of transcri
ption factors"}

> <broad_targets>
{MAPK14}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{Losmapimod,585543-15-3,585543153,GSK-AHAB,GSKAHAB,GW856553,GW856553X,"Losmapimod (GW856553X)",GW-856553,UNII-F2DQF16BXE,UNIIF2DQF16BXE,F2DQF16BXE,GSK-AHAB;GW856553X;SB856553,GSKAHAB;GW856553X;SB85655
3,"Losmapimod (USAN:INN)","GW 856553X","SB 856553","Losmapimod (USAN/INN)",GTPL7835,SCHEMBL107040,T2277}

> <pdid>
PD010391

> <targets>
{"p38 MAPK",p38¦Á,p38¦Â,Autophagy}

> <classes>
{MAPK,Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{11552706}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 39  0  0  0  0            999 V2000
  -14.0594   -9.6208    0.0000 C   0  0
  -12.9718   -8.5878    0.0000 N   0  0
  -13.3230   -7.1295    0.0000 C   0  0
  -11.5323   -9.0126    0.0000 C   0  0
  -10.4441   -7.9791    0.0000 C   0  0
   -9.0046   -8.4038    0.0000 N   0  0
   -8.6534   -9.8621    0.0000 C   0  0
   -7.9164   -7.3703    0.0000 C   0  0
   -8.2701   -5.9126    0.0000 C   0  0
   -7.1846   -4.8774    0.0000 C   0  0
   -5.7452   -5.2998    0.0000 C   0  0
   -5.3916   -6.7576    0.0000 C   0  0
   -6.4771   -7.7928    0.0000 C   0  0
   -6.1201   -9.2506    0.0000 N   0  0
   -4.6795   -9.6712    0.0000 C   0  0
   -3.5958   -8.6341    0.0000 O   0  0
   -4.3225  -11.1290    0.0000 C   0  0
   -2.8827  -11.5494    0.0000 C   0  0
   -4.6570   -4.2663    0.0000 N   0  0
   -3.2175   -4.6910    0.0000 C   0  0
   -2.8628   -6.1485    0.0000 N   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -7.5416   -3.4196    0.0000 O   0  0
   -8.9814   -2.9992    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  2  0
 11 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 24 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 26  1  0
 34 29  1  0
 10 35  1  0
 35 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28759

> <plate>
Kinase v5-3

> <well>
E13

> <supplier_cmpd_name>
AZ5104

> <ctcr_id>
11528

> <supplier_cmpd_id>
S7298

> <smiles>
CN(C)CCN(C)c1cc(c(cc1NC(=O)C=C)Nc1nccc(n1)c1c[nH]c2ccccc12)OC

> <pd_targets>
{KCNH2,EGFR,ERBB2,ERBB3,ERBB4}

> <pathway_gtopdb>
{"Ion channel",Enzyme,"Voltage-gated ion channel",Kinase,"Potassium channels","Protein Kinase","Voltage-gated potassium channel","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{"Ion channels",Receptors,"Voltage-gated ion channels","Catalytic receptors","Potassium channels","Receptor kinases","Voltage-gated potassium channels","TK: Tyrosine kinase","Receptor tyrosine kinases
 (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Muscle contraction","Signal Transduction","Cardiac conduction","Signaling by GPCR","Phase 3 - rapid repolarisation","GPCR downstream signalling","G alpha (q) signalling events","Gastrin-CREB signall
ing pathway via PKC and MAPK","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{AZ5104,1421373-98-9,1421373989,AZ-5104,UNII-2DWZ6SE1E1,UNII2DWZ6SE1E1,2DWZ6SE1E1,CHEMBL3353411,AZD5104,"AZ 5104","Osimertinib metabolite M6",SCHEMBL14663428,EX-A824,EXA824,AMY16678,AOB87166,BCP08428,
HY-B0793,HYB0793,BDBM50029689,MFCD28899992,s7298,AKOS025404698,ZINC147059673,CCG-269587,CCG269587,CS,T2491}

> <pdid>
PD012313

> <targets>
{EGFR,"EGFR (L858R)","EGFR (L858R/T790M)","EGFR (L861Q)","EGFR (wildtype)",HER2/ErbB2}

> <classes>
{Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors,JAK/STAT Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{71496460}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  1  0            999 V2000
    3.8983   -0.7512    0.0000 F   0  0
    2.5988   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2526    1.3618    0.0000 C   0  0
   -5.5608    2.8298    0.0000 Cl  0  0
   -6.2524    0.2436    0.0000 N   0  0
   -7.7454    0.3952    0.0000 C   0  0  2  0  0  0
   -8.4584    1.7093    0.0000 C   0  0  1  0  0  0
   -7.6746    2.9883    0.0000 F   0  0
   -9.9579    1.7482    0.0000 C   0  0
  -10.7413    0.4691    0.0000 N   0  0
  -12.2415    0.5080    0.0000 C   0  0
  -13.2244    1.5929    0.0000 C   0  0
  -14.3106    0.5583    0.0000 O   0  0
  -13.2760   -0.5278    0.0000 C   0  0
  -10.0252   -0.8490    0.0000 C   0  0
   -8.5257   -0.8879    0.0000 C   0  0
   -5.4979   -1.0529    0.0000 N   0  0
   -4.0317   -0.7359    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3032   -3.7490    0.0000 C   0  0
    2.5983   -3.0004    0.0000 F   0  0
    3.8975   -2.2510    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
  9 11  1  0
 12 11  1  1
 12 13  1  0
 13 14  1  6
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 17  1  0
 16 21  1  0
 21 22  1  0
 22 12  1  0
 11 23  1  0
 23 24  2  0
 24  8  1  0
  6 25  1  0
 25 26  2  0
 26  3  1  0
 26 27  1  0
 27 28  1  0
  2 29  1  0
  2 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28760

> <plate>
Kinase v5-3

> <well>
E15

> <supplier_cmpd_name>
GNE-9605

> <ctcr_id>
11462

> <supplier_cmpd_id>
S7368

> <smiles>
FC(c1cnc(Nc2c(Cl)n([C@@H]3[C@@H](F)CN(C4COC4)CC3)nc2)nc1NC)(F)F

> <pd_targets>
{LRRK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase LRRK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","Leucine-rich repeat kinase (LRRK) family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Non-Receptor Tyrosine Kinases","Signaling by PTK6","PTK6 promotes HIF1A stabilization"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{GNE-9605,GNE9605,1536200-31-3,1536200313,CHEMBL3122117,"GNE 9605",GTPL7919,BCP10209,EX-A2064,EXA2064,BDBM50448110,s7368,AKOS032947345,ZINC103260612,CCG-269231,CCG269231,CS-3297,CS3297,SB19412,NCGC003
86367-02,NCGC0038636702,NCGC00386367-03,NCGC0038636703,NCGC00386367-04,NCGC0038636704,BS-15967,BS15967,HY-12282,HY12282,Q27077825,T1770}

> <pdid>
PD021563

> <targets>
{LRRK2}

> <classes>
{Autophagy}

> <pubchem_cids>
{76328936}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
    5.1932   -3.0130    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
   -0.0125   -5.9981    0.0000 N   0  0
   -0.0156   -7.4989    0.0000 C   0  0
    1.2822   -8.2511    0.0000 O   0  0
   -1.3164   -8.2475    0.0000 N   0  0
   -1.3194   -9.7483    0.0000 C   0  0
   -2.6184  -10.4984    0.0000 C   0  0
   -2.6184  -11.9984    0.0000 C   0  0
   -1.3194  -12.7484    0.0000 C   0  0
   -0.0203  -11.9984    0.0000 C   0  0
   -0.0203  -10.4984    0.0000 C   0  0
    1.2794  -12.7488    0.0000 C   0  0
    1.2804  -14.2488    0.0000 F   0  0
    2.5782  -11.9984    0.0000 F   0  0
    2.5788  -13.4982    0.0000 F   0  0
   -3.9175   -9.7485    0.0000 F   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.4133    1.7530    0.0000 C   0  0
   -3.8794    1.4442    0.0000 C   0  0
   -4.8823    2.5608    0.0000 C   0  0
   -6.3600    2.3926    0.0000 C   0  0
   -6.9656    3.7649    0.0000 C   0  0
   -5.8476    4.7650    0.0000 C   0  0
   -4.5510    4.0107    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.5532    4.4223    0.0000 O   0  0
   -0.3115    2.9665    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 16 18  1  0
 18 19  1  0
 18 20  1  0
 18 21  1  0
 13 22  1  0
  3 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 27 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 32  1  0
 30 37  1  0
 37 38  2  0
 37 39  1  0
 39 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28761

> <plate>
Kinase v5-3

> <well>
E17

> <supplier_cmpd_name>
GNF-5837

> <ctcr_id>
12420

> <supplier_cmpd_id>
S7519

> <smiles>
Cc1c(cc(cc1)NC(=O)Nc1c(ccc(c1)C(F)(F)F)F)Nc1cc2c(cc1)/C(=C/c1ccc[nH]1)/C(=O)N2

> <pd_targets>
{NTRK3,NTRK1,FGFR4,NTRK2,EPHB2,LYN,BMX,KIT,INSR,CSF1R,FLT1,FGR,ZAP70,SRC,RET,PDGFRB,FGFR3,ALK,TIE1,FLT3,MET,MAPK9,IGF1R,MST1R,EPHA3,ROS1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","CMGC protein kinase group","Tyrosine protein kinase Trk family","Tyrosine protein kinase FGFR family","Tyrosine pr
otein kinase Eph family","Tyrosine protein kinase Src family","Tyrosine protein kinase Tec family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase InsR family","Tyrosine protein kinase
 VEGFR family","Tyrosine protein kinase Syk family","Tyrosine protein kinase Ret family","TKL protein kinase STKR family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Met family","CMG
C protein kinase MAPK family","Tyrosine protein kinase Sev family","TKL protein kinase STKR Type 1 subfamily","CMGC protein kinase JNK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases
)","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","JNK subfamily","Type VII RTKs: Neurotrophin receptor/Trk family","Type V RTKs: FGF (fibroblast growth factor) receptor fa
mily","Type XIII RTKs: Ephrin receptor family","Src family","Tec family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type II RTKs: Insulin receptor family","Type IV RTKs: VEGF (vascular en
dothelial growth factor) receptor family","Syk family","Type XIV RTKs: RET","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Type
 X RTKs: HGF (hepatocyte growth factor) receptor family","Type XVII RTKs: ROS receptors"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology",Disease,Metabolism,"Gene expression (Transcription)","Immune System","Signaling by Receptor Tyrosine Kinases","Nervous system development","Infectious di
sease","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second messengers","Intracellular signaling by second messengers","RNA Polymerase II Transcription","Adapt
ive Immune System","Innate Immune System","Signaling by NTRKs","Signaling by FGFR","Axon guidance","Leishmania infection","Phospholipid metabolism","Signaling by KIT in disease","PIP3 activates AKT si
gnaling","Generic Transcription Pathway","Signaling by VEGF","TCR signaling","Signaling by FGFR in disease","Signaling by Insulin receptor","Toll-like Receptor Cascades","Signaling by Type 1 Insulin-l
ike Growth Factor 1 Receptor (IGF1R)","Signaling by MST1","Signaling by NTRK3 (TRKC)","Signaling by NTRK1 (TRKA)","Signaling by FGFR4","EPH-Ephrin signaling","Leishmania parasite growth and survival",
"PI Metabolism","Drug resistance of KIT mutants","Negative regulation of the PI3K/AKT network","Transcriptional Regulation by VENTX","VEGF ligand-receptor interactions","Generation of second messenger
 molecules","RET signaling","Signaling by FGFR3 in disease","Insulin receptor signalling cascade","Semaphorin interactions","Toll Like Receptor 5 (TLR5) Cascade","IGF1R signaling cascade","Activated N
TRK3 signals through PI3K","Signalling to ERKs","Downstream signaling of activated FGFR4","Activation of TRKA receptors","EPHB-mediated forward signaling","Anti-inflammatory response favouring Leishma
nia parasite infection","Synthesis of PIPs at the plasma membrane","Dasatinib-resistant KIT mutants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","VEGF binds to VEGFR leading to receptor dimerizat
ion","Signaling by FGFR3 point mutants in cancer","IRS-mediated signalling","Sema4D in semaphorin signaling","MyD88 cascade initiated on plasma membrane","IRS-related events triggered by IGF1R","EPHA-
mediated growth cone collapse","Prolonged ERK activation events","FRS-mediated FGFR4 signaling","NGF-independant TRKA activation","FCGR3A-mediated IL10 synthesis","Signalling to RAS","FGFR3 mutant rec
eptor activation","PI3K Cascade","Sema4D mediated inhibition of cell attachment and migration","MAP kinase activation","ARMS-mediated activation","p38MAPK events","Signaling by activated point mutants
 of FGFR3","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{NTRK1,NTRK2,NTRK3}

> <broad_moa>
{"growth factor receptor inhibitor"}

> <synonyms>
{NF583,GNF-5837,GNF5837,1033769-28-6,1033769286,"GNF 5837",CHEMBL2037226,C28H21F4N5O2,GTPL8071,SCHEMBL3610213,AOB4949,EX-A271,EXA271,SYN1183,HMS3886B17,2435AH,BDBM50384727,MFCD24386809,s7519,ZINC84706
784,AKOS024458224,CCG-269941,CCG269941,CS-1728,CS1728,NCGC00346936-09,NCGC0034693609,AC-32993,AC32993,AS-16319,AS16319,T6097}

> <pdid>
PD012859

> <targets>
{"Trk receptor",Kit,PDGFR¦Â,TrkA,TrkB,TrkC}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{59397065}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 40  0  0  1  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -3.9069    5.2492    0.0000 N   0  0
   -5.2089    5.9957    0.0000 C   0  0
   -5.3543    7.4758    0.0000 C   0  0
   -6.8231    7.7802    0.0000 C   0  0
   -7.4401    9.1474    0.0000 C   0  0
   -7.5665    6.4774    0.0000 N   0  0
   -6.5572    5.3678    0.0000 N   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -6.4939    0.7411    0.0000 C   0  0
   -6.4894   -0.7597    0.0000 C   0  0
   -7.7864   -1.5148    0.0000 C   0  0
   -7.7841   -3.0149    0.0000 C   0  0
   -9.0819   -3.7670    0.0000 C   0  0
  -10.3821   -3.0191    0.0000 C   0  0
  -10.3846   -1.5191    0.0000 C   0  0
   -9.0867   -0.7670    0.0000 C   0  0
   -3.8967    0.7484    0.0000 N   0  0
    8.9987    4.5656    0.0000 O   0  0
    8.9987    3.0656    0.0000 C   0  0  2  0  0  0
    7.6987    2.3156    0.0000 C   0  0  1  0  0  0
    7.6987    0.8156    0.0000 O   0  0
    6.3987    3.0656    0.0000 C   0  0
    6.3987    4.5656    0.0000 O   0  0
    5.0994    2.3160    0.0000 O   0  0
   10.2987    2.3156    0.0000 C   0  0
   10.2987    0.8156    0.0000 O   0  0
   11.5980    3.0652    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 14 16  1  0
 16 17  1  0
 17 12  2  0
 10 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 19 28  2  0
 28  8  1  0
 30 29  1  1
 30 31  1  0
 31 32  1  1
 31 33  1  0
 33 34  1  0
 33 35  2  0
 30 36  1  0
 36 37  1  0
 36 38  2  0
M  END
> <name>
UTKinase_V5

> <id>
28762

> <plate>
Kinase v5-3

> <well>
H06

> <supplier_cmpd_name>
ENMD-2076 L-(+)-Tartaric acid

> <ctcr_id>
7737

> <supplier_cmpd_id>
S2018

> <smiles>
CN1CCN(CC1)c2cc(Nc3cc(C)[nH]n3)nc(\C=C\c4ccccc4)n2.O[C@H]([C@@H](O)C(O)=O)C(O)=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"NMD2076 L(+)TARTARIC ACI","ENMD-2076 L-(+)-Tartaric acid","ENMD2076 L(+)Tartaric acid",UNII-KXQ762CQTH,UNIIKXQ762CQTH,"ENMD-2076  tartrate","ENMD2076  tartrate",KXQ762CQTH,1291074-87-7,1291074877,"1
453868-32-0  (tartrate)","1453868320  (tartrate)",1453868-32-0,1453868320,"ENMD-981693 L-tartrate","ENMD981693 Ltartrate",SCHEMBL15239835,C21H25N7.C4H6O6,C25H31N7O6,2396AH,MFCD18074523,s,S1181,ENMD-20
76}

> <pdid>

> <targets>
{"Aurora Kinase",FLT3,VEGFR}

> <classes>
{}

> <pubchem_cids>
{24776050}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
   -5.8711   -8.4062    0.0000 C   0  0
   -4.8831   -8.5607    0.0000 N   0  0
   -4.3432   -9.9602    0.0000 C   0  0
   -3.9401   -7.3931    0.0000 C   0  0
   -2.4573   -7.6249    0.0000 C   0  0
   -1.5144   -6.4573    0.0000 C   0  0
   -0.0316   -6.6892    0.0000 C   0  0
    0.5116   -8.0874    0.0000 C   0  0
    1.9941   -8.3161    0.0000 N   0  0
    2.9334   -7.1466    0.0000 C   0  0
    4.4158   -7.3753    0.0000 C   0  0
    2.3903   -5.7483    0.0000 C   0  0
    3.3277   -4.5763    0.0000 N   0  0
    2.7822   -3.1780    0.0000 C   0  0
    3.7175   -2.0053    0.0000 N   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
    0.0000    3.2286    0.0000 S   0  0
   -1.3515    1.0777    0.0000 N   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -3.1695   -0.6090    0.0000 C   0  0
   -3.7175   -2.0053    0.0000 C   0  0
   -2.7822   -3.1781    0.0000 C   0  0
   -1.2990   -2.9545    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 N   0  0
   -5.2015   -2.2290    0.0000 C   0  0
   -6.1375   -1.0569    0.0000 F   0  0
   -5.5666   -3.1600    0.0000 F   0  0
   -6.6847   -2.4533    0.0000 F   0  0
    0.9077   -5.5197    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
 28 17  1  0
 28 29  2  0
 29 14  1  0
 24 30  1  0
 30 31  1  0
 30 32  1  0
 30 33  1  0
 12 34  2  0
 34  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28765

> <plate>
Kinase v5-3

> <well>
G03

> <supplier_cmpd_name>
MLN0905

> <ctcr_id>
4093

> <supplier_cmpd_id>
S2898

> <smiles>
CN(C)CCCc1cnc(C)c(Nc2ncc3CC(=S)Nc4cc(ccc4c3n2)C(F)(F)F)c1

> <pd_targets>
{PLK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase PLK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Polo-like kinase (PLK) family"}

> <pathway_reactome>
{"Cell Cycle",Mitotic,"Mitotic G2-G2/M phases","G2/M Transition","Centrosome maturation","Loss of proteins required for interphase microtubule organization from the centrosome","Loss of Nlp from mitot
ic centrosomes"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MLN0905,1228960-69-7,1228960697,MLN-0905,"MLN 0905",GTPL9402,SCHEMBL2255230,CHEMBL1945805,C24H25F3N6S,DTXSID30673165,BCP05348,EX-A2105,EXA2105,2556AH,NSC767470,s2898,ZINC82157362,AKOS026750606,CCG-26
9593,CCG269593,CS-1081,CS1081,NSC-767470,PB23134,QC-9272,QC9272,"compound 12c (PMID: 220706",T2704,S2898}

> <pdid>
PD012637

> <targets>
{PLK}

> <classes>
{}

> <pubchem_cids>
{46235922}

$$$$
UTKinase_V5
  SciTegic11012413002D

 12 12  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 C   0  0
   -2.5951    3.0031    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -2.5951   -3.0031    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
  8 11  2  0
 11  2  1  0
 11 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28766

> <plate>
Kinase v5-3

> <well>
G05

> <supplier_cmpd_name>
Pyridoxine

> <ctcr_id>
4871

> <supplier_cmpd_id>
S3980

> <smiles>
Cc1ncc(CO)c(CO)c1O

> <pd_targets>
{HPGD,HSD17B10,KDM4E,ALDH1A1,LMNA}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Oxidoreductase,Eraser,"Lysine demethylase","Jumonji domain-containing","Other nuclear protein"}

> <pathway_chembl>
{Enzymes,"Eicosanoid turnover","Chromatin modifying enzymes","Prostaglandin synthases","1.14.11.- Histone demethylases"}

> <pathway_reactome>
{Metabolism,"Metabolism of lipids","Metabolism of amino acids and derivatives","Biological oxidations","Biosynthesis of specialized proresolving mediators (SPMs)","Branched-chain amino acid catabolism
","Phase I - Functionalization of compounds","Biosynthesis of DHA-derived SPMs","Ethanol oxidation","Biosynthesis of D-series resolvins","Cell Cycle",Mitotic,"M Phase","Mitotic Metaphase and Anaphase"
,"Mitotic Anaphase","Nuclear Envelope (NE) Reassembly","Initiation of Nuclear Envelope (NE) Reformation"}

> <broad_targets>
{DDC,PDXK}

> <broad_moa>
{"vitamin B"}

> <synonyms>
{pyridoxine,65-23-6,65236,"vitamin B6",Pyridoxol,Gravidox,Pyridoxin,"3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine","3hydroxy4,5bis(hydroxymethyl)2methylpyridine",Hydoxin,Adermine,Pyridoxolum,"3,4
-Pyridinedimethanol, 5-hydroxy-6-methyl-","3,4Pyridinedimethanol, 5hydroxy6methyl","5-Hydroxy-6-methyl-3,4-pyridinedimethanol","5Hydroxy6methyl3,4pyridinedimethanol",4,5-bis(hyd,5bis(hyd,T3O2784,T0973
,1505453,"Vitamin B6",Pyridoxine,PYRIDOXINE}

> <pdid>
PD010192

> <targets>
{Vitamin}

> <classes>
{"enzyme cofactor","vitamin B6"}

> <pubchem_cids>
{1054}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 41  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 O   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -7.7985    1.4932    0.0000 N   0  0
   -7.7985    2.9932    0.0000 C   0  0
   -6.4995    3.7432    0.0000 N   0  0
   -5.2004    2.9933    0.0000 C   0  0
   -9.0982    3.7435    0.0000 C   0  0
  -10.3985    2.9956    0.0000 C   0  0
  -11.6964    3.7476    0.0000 C   0  0
  -11.6941    5.2476    0.0000 C   0  0
  -10.3939    5.9956    0.0000 C   0  0
  -10.3884    7.4964    0.0000 C   0  0
   -9.0864    8.2430    0.0000 N   0  0
   -7.7911    7.4865    0.0000 N   0  0
   -6.4883    8.2300    0.0000 C   0  0
   -6.4808    9.7299    0.0000 C   0  0
   -7.7760   10.4864    0.0000 C   0  0
   -9.0788    9.7430    0.0000 C   0  0
  -10.3741   10.4995    0.0000 O   0  0
   -5.1924    7.4731    0.0000 C   0  0
   -5.1974    5.9730    0.0000 C   0  0
   -3.9010    5.2186    0.0000 C   0  0
   -2.5994    5.9641    0.0000 C   0  0
   -2.5942    7.4641    0.0000 C   0  0
   -3.8907    8.2186    0.0000 C   0  0
   -1.2919    8.2101    0.0000 C   0  0
    0.0097    8.9556    0.0000 N   0  0
   -9.0960    5.2436    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  3
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 20  1  0
 25 26  2  0
 22 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 31 33  1  0
 33 34  3  0
 18 35  2  0
 35 14  1  0
  5 36  1  0
 36 37  1  0
 37  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28767

> <plate>
Kinase v5-3

> <well>
G07

> <supplier_cmpd_name>
Tepotinib (EMD 1214063)

> <ctcr_id>
5094

> <supplier_cmpd_id>
Se S7067

> <smiles>
CN1CCC(COc2cnc(nc2)c3cccc(CN4N=C(C=CC4=O)c5cccc(c5)C#N)c3)CC1

> <pd_targets>
{MET}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Semaphorin interactions","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{MET}

> <broad_moa>
{"hepatocyte growth factor receptor inhibitor"}

> <synonyms>
{Tepotinib(EMD-1214063),Tepotinib(EMD1214063),CHEMBL3402762,Tepotinib,1100598-32-0,1100598320,EMD-1214063,EMD1214063,"EMD 1214063",UNII-1IJV77EI07,UNII1IJV77EI07,MSC2156119,"Tepotinib (EMD 1214063)",M
SC2156119J,1IJV77EI07,MSC-2156119J,MSC-2156119,C29H28N6O2,"Tepotinib (INN)",Tepmetko,Tepo,T6121,S7067}

> <pdid>
PD012734

> <targets>
{c-Met}

> <classes>
{}

> <pubchem_cids>
{25171648}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 34  0  0  0  0            999 V2000
    5.2029   -2.9932    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
    6.4990   -0.7409    0.0000 C   0  0
    7.8525   -1.3573    0.0000 N   0  0
    8.8523   -0.2391    0.0000 C   0  0
    8.0978    1.0574    0.0000 C   0  0
    6.6317    0.7404    0.0000 S   0  0
    8.6996    2.4295    0.0000 C   0  0
   10.1906    2.5941    0.0000 O   0  0
    7.8115    3.6393    0.0000 N   0  0
    8.4143    5.0137    0.0000 C   0  0
    7.5284    6.2242    0.0000 C   0  0
    8.1337    7.5967    0.0000 C   0  0
    9.6249    7.7587    0.0000 C   0  0
   10.2302    9.1312    0.0000 Cl  0  0
   10.5109    6.5483    0.0000 C   0  0
    9.9056    5.1759    0.0000 N   0  0
    7.2473    8.8078    0.0000 C   0  0
    5.7559    8.6467    0.0000 F   0  0
    7.8530   10.1800    0.0000 F   0  0
    6.3619   10.0186    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 12  6  1  0
 12 13  1  0
  2 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 14  1  0
 17 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 25 27  1  0
 27 28  2  0
 28 22  1  0
 24 29  1  0
 29 30  1  0
 29 31  1  0
 29 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28768

> <plate>
Kinase v5-3

> <well>
G09

> <supplier_cmpd_name>
MLN2480

> <ctcr_id>
2185

> <supplier_cmpd_id>
S7121

> <smiles>
CC(NC(=O)c1ncnc(N)c1Cl)c2ncc(s2)C(=O)Nc3cc(c(Cl)cn3)C(F)(F)F

> <pd_targets>
{BRAF,ARAF,RAF1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase RAF family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","RAF family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by NTRKs","Signaling by NTRK1 (TRKA)","Signalling to ERKs","Prolonged ERK activation events","ARMS-mediated activation"}

> <broad_targets>
{}

> <broad_moa>
{"RAF inhibitor"}

> <synonyms>
{SCHEMBL4204782,AK316256,AS-75178,AS75178,"AS 75178",S7121,MLN2480}

> <pdid>
PD003661

> <targets>
{Raf}

> <classes>
{}

> <pubchem_cids>
{57569468}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
    4.9573   -8.7775    0.0000 C   0  0
    4.4162   -7.3785    0.0000 O   0  0
    2.9334   -7.1466    0.0000 C   0  0
    2.3903   -5.7483    0.0000 C   0  0
    3.3277   -4.5763    0.0000 N   0  0
    2.7822   -3.1780    0.0000 C   0  0
    3.7175   -2.0053    0.0000 N   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 N   0  0
    2.5242    2.0130    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
    0.0000    3.2286    0.0000 O   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -1.0833    2.5536    0.0000 F   0  0
   -2.7307    0.4880    0.0000 F   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 N   0  0
   -1.4011   -2.9095    0.0000 C   0  0
   -2.8823   -3.0806    0.0000 C   0  0
   -3.1625   -4.5542    0.0000 C   0  0
   -1.8476   -5.2761    0.0000 C   0  0
   -0.7547   -4.2486    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 N   0  0
    0.9077   -5.5197    0.0000 C   0  0
   -0.0316   -6.6892    0.0000 C   0  0
    0.5116   -8.0874    0.0000 C   0  0
    1.9941   -8.3161    0.0000 C   0  0
   -0.4258   -9.2595    0.0000 C   0  0
   -1.9086   -9.0334    0.0000 O   0  0
    0.1197  -10.6577    0.0000 N   0  0
   -0.8177  -11.8297    0.0000 C   0  0
   -0.2746  -13.2280    0.0000 C   0  0
   -1.2138  -14.3975    0.0000 C   0  0
   -2.6963  -14.1689    0.0000 N   0  0
   -3.6356  -15.3384    0.0000 C   0  0
   -3.2395  -12.7707    0.0000 C   0  0
   -2.3002  -11.6011    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 14 16  1  0
 14 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 19  1  0
 18 24  1  0
 24  9  1  0
 24 25  2  0
 25  6  1  0
  4 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29  3  1  0
 28 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 36 38  1  0
 38 39  1  0
 39 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28769

> <plate>
Kinase v5-3

> <well>
G11

> <supplier_cmpd_name>
Ro3280

> <ctcr_id>
11928

> <supplier_cmpd_id>
S7248

> <smiles>
COc1c(Nc2ncc3N(C)C(=O)C(F)(F)CN(C4CCCC4)c3n2)ccc(c1)C(=O)NC1CCN(C)CC1

> <pd_targets>
{PLK1,FER,TTK,PLK3,PLK2,MYLK,DAPK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","TK protein kinase group","CAMK protein kinase group","Other protein kinase PLK family","Tyrosine protein kinase Fer family","Other protein
 kinase TTK family","CAMK protein kinase MLCK family","CAMK protein kinase DAPK family","Other protein kinase PLK2"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","TK: Tyrosine kinase","Myosin Light Chai
n Kinase (MLCK) family","Death-associated kinase (DAPK) family","Polo-like kinase (PLK) family","Non-receptor tyrosine kinases (nRTKs)","TTK family","Fer family"}

> <pathway_reactome>
{"Cell Cycle","Signal Transduction","Gene expression (Transcription)",Disease,"Programmed Cell Death",Mitotic,"Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Infectious dis
ease","Signaling by Rho GTPases",Apoptosis,"Mitotic G2-G2/M phases","Signaling by SCF-KIT","Generic Transcription Pathway","Leishmania infection","RHO GTPase Effectors","Caspase activation via extrins
ic apoptotic signalling pathway","G2/M Transition","Transcriptional Regulation by TP53","Leishmania parasite growth and survival","RHO GTPases activate PAKs","Caspase activation via Dependence Recepto
rs in the absence of ligand","Centrosome maturation","Regulation of TP53 Activity","Anti-inflammatory response favouring Leishmania parasite infection","Loss of proteins required for interphase microt
ubule organization from the centrosome","Regulation of TP53 Activity through Phosphorylation","CD163 mediating an anti-inflammatory response","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Ro3280,1062243-51-9,1062243519,PharmaGSID_48511,PharmaGSID48511,PharmaGSID-48511,"PharmaGSID 48511",Ro5203280,CHEMBL2392553,"Ro 3280",79C,DSSTox_CID_28485,DSSToxCID28485,DSSTox-CID-28485,"DSSTox CID 
28485",DSSTox_RID_82762,DSSToxRID82762,DSSTox-RID-82762,"DSSTox RID 82762",DSSTox_GSID_48511,DSSToxGSID48511,DSSTox-GSID-48511,"DSSTox GSID 48511",GTPL9403,SCHEMBL1559146,DTXSID4048511,AOB5394,C27H35F
2N7O3,HMS3653O21,Ro-3280,BCP07189,EX-A2150,EXA2150,Tox21_303518,Tox21303518,Tox21-303518,"Tox21 303518",BDBM50435,T2634,"RO 3280"}

> <pdid>
PD010383

> <targets>
{PLK,PLK1}

> <classes>
{"Cell Cycle/Checkpoint"}

> <pubchem_cids>
{25015677}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    3.1882    2.6402    0.0000 C   0  0
    2.7248    1.2135    0.0000 N   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    3.1884   -2.6409    0.0000 C   0  0
    4.6235   -3.0601    0.0000 C   0  0
    4.9782   -4.5176    0.0000 C   0  0
    3.8933   -5.5535    0.0000 C   0  0
    2.4538   -5.1320    0.0000 C   0  0
    2.0991   -3.6745    0.0000 C   0  0
    4.5427   -6.9048    0.0000 N   0  0
    6.0293   -6.7043    0.0000 C   0  0
    6.2980   -5.2286    0.0000 C   0  0
    3.8344   -8.2250    0.0000 C   0  0
    2.3351   -8.2713    0.0000 O   0  0
    4.6241   -9.5013    0.0000 C   0  0
    3.9146  -10.8238    0.0000 C   0  0
    4.7020  -12.1005    0.0000 C   0  0
    3.9902  -13.4208    0.0000 C   0  0
    2.4908  -13.4645    0.0000 C   0  0
    1.7033  -12.1879    0.0000 C   0  0
    2.4152  -10.8675    0.0000 C   0  0
    4.7782  -14.6981    0.0000 C   0  0
    6.2775  -14.6554    0.0000 F   0  0
    4.0659  -16.0183    0.0000 F   0  0
    5.5651  -15.9752    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 10 11  1  0
  4 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  1  0
 19 20  1  0
 20 14  1  0
 18 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 26 30  1  0
 30 31  1  0
 30 32  1  0
 30 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28770

> <plate>
Kinase v5-3

> <well>
G13

> <supplier_cmpd_name>
GSK2606414

> <ctcr_id>
11586

> <supplier_cmpd_id>
S7307

> <smiles>
Cn1cc(c2c1ncnc2N)c1cc2c(cc1)N(CC2)C(=O)Cc1cc(ccc1)C(F)(F)F

> <pd_targets>
{MAP3K9,WNK2,AXL,RET,PTK6,KIT,CYP3A4,EIF2AK3,EIF2AK1,MERTK,RIPK1,YES1,NEK4,NTRK3,CYP2C19,CYP2C9,MAP4K5,MAP3K11,MAP3K10,CYP2D6,CYP1A2,CYP2C8,NTRK2,IKBKE,MYLK2,LCK,DDR2,AURKB,EIF2AK2,NTRK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 3","Cytochrome P450 family 2","Cytochrome P450 family 1","TKL protein kinase group","Other protein kinase group","TK protein k
inase group","Cytochrome P450 family 3A","Cytochrome P450 family 2C","STE protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 1A","CAMK protein kinase group","TKL protein kinase 
MLK family","Other protein kinase Wnk family","Tyrosine protein kinase Axl family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Src family","Tyrosine protein kinase PDGFR family","Cyt
ochrome P450 3A4","Other protein kinase PEK family","TKL protein kinase RIPK family","Other protein kinase NEK family","Tyrosine protein kinase Trk family","Cytochrome P450 2C19","Cytochrome P450 2C9"
,"STE protein kinase STE20 family","Cytochrome P450 2D6","Cytochrome P450 1A1","Cytochrome P450 2C8","CAMK protein kinase MLCK family","Tyrosine protein kinase DDR family","Other protein kinase AUR fa
mily","TKL protein kinase MLK subfamily","Other protein kinase PEK subfamily","Other protein kinase HRI","STE protein kinase KHS subfamily","Other protein kinase PKR"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Cytochrome P450","Kinases (EC 2.7.x.x)","Receptor kinases","CYP3 family","CYP2 family: drug metabolising subset","STE: Homologs of yeast Sterile 7","Sterile 1
1","Sterile 20 kinases","CYP1 family","CAMK: Calcium/calmodulin-dependent protein kinases","TKL: Tyrosine kinase-like","Other protein kinases","TK: Tyrosine kinase","STE20 family","Myosin Light Chain 
Kinase (MLCK) family","Mixed Lineage Kinase (MLK) family","Wnk family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","PEK family","Receptor interacting protein kinase (RIP
K) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","KHS subfamily","IKK family","Aurora kinase (Aur) family","MLK subfamily","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) recepto
r family","Type XIV RTKs: RET","Src family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","PEK subfamily","Other PEK family kinases","Type VII RTKs: Neurotrophin receptor/Trk family","Type XV
I RTKs: DDR (collagen receptor) family"}

> <pathway_reactome>
{"Transport of small molecules","Signal Transduction","Developmental Biology","Cell Cycle",Disease,Metabolism,"Metabolism of proteins","Cellular responses to external stimuli",Hemostasis,"Immune Syste
m","Extracellular matrix organization","Ion channel transport","Signaling by Receptor Tyrosine Kinases","Nervous system development",Mitotic,"Diseases of signal transduction by growth factor receptors
 and second messengers","Metabolism of lipids","Unfolded Protein Response (UPR)","Cellular responses to stress","Cell surface interactions at the vascular wall","Innate Immune System","Infectious dise
ase","Biological oxidations","Non-integrin membrane-ECM interactions","Stimuli-sensing channels","Signaling by VEGF","Axon guidance","Mitotic G1 phase and G1/S transition","Signaling by KIT in disease
","Biosynthesis of specialized proresolving mediators (SPMs)","PERK regulates gene expression","Response of EIF2AK1 (HRI) to heme deficiency","Toll-like Receptor Cascades","Leishmania infection","Sign
aling by NTRKs","Phase I - Functionalization of compounds","Oncogenic MAPK signaling","HIV Infection","M Phase","Influenza Infection","VEGFA-VEGFR2 Pathway","RET signaling","G1 Phase","Drug resistance
 of KIT mutants","Biosynthesis of DHA-derived SPMs","Toll Like Receptor 4 (TLR4) Cascade","Leishmania parasite growth and survival","Signaling by NTRK3 (TRKC)","Cytochrome P450 - arranged by substrate
 type","Signaling by RAS mutants","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Mitotic Metaphase and Anaphase","NS1 Mediated Effects on Host Pathways","Cyclin D associated events in
 G1","Dasatinib-resistant KIT mutants","Biosynthesis of maresins","MyD88-independent TLR4 cascade","Anti-inflammatory response favouring Leishmania parasite infection","Activated NTRK3 signals through
 PI3K",Xenobiotics,"Signaling downstream of RAS mutants","Activation of TRKA receptors","The role of Nef in HIV-1 replication and disease pathogenesis","Mitotic Anaphase","Inhibition of PKR","Signalli
ng to ERKs","Biosynthesis of maresin-like SPMs","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3A-mediated IL10 synthesis","CYP2E1 reactions","Aromatic amines can be N-hydroxylated or N-dealkylated by CY
P1A2","NGF-independant TRKA activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Separation of Sister Chromatids","Prolonged ERK activation eve
nts","IKK complex recruitment mediated by RIP1","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Nef Mediated CD4 Down-regulation","ARMS-mediated activation"}

> <broad_targets>
{EIF2AK3,MYLK2}

> <broad_moa>
{"protein kinase inhibitor"}

> <synonyms>
{GSK2606414,1337531-36-8,1337531368,"GSK 2606414",GSK-2606414,CHEMBL2171124,C24H20F3N5O,Tube501,SCHEMBL868254,AOB3888,EX-A340,EXA340,SYN1201,HMS3653O10,HMS3743C19,BCP06992,BDBM50396534,MFCD25976926,NS
C781627,s7307,ZINC95550949,AKOS024458496,CCG-269247,CCG269247,CS-1428,CS1428,EK-,EK,T2614}

> <pdid>
PD010356

> <targets>
{PERK,"eIF-2AK1 (HRI)","eIF-2AK2 (PKR)","eIF-2AK3 (PERK)"}

> <classes>
{Apoptosis}

> <pubchem_cids>
{53469448}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 20  0  0  1  0            999 V2000
    7.5973    0.8802    0.0000 Cl  0  5
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0  2  0  0  0
   -4.0317   -0.7359    0.0000 N   0  0
   -5.4979   -1.0529    0.0000 C   0  0
   -6.2524    0.2436    0.0000 C   0  0  1  0  0  0
   -7.7447    0.3952    0.0000 O   0  0
   -5.2526    1.3618    0.0000 C   0  0  2  0  0  0
   -5.5610    2.8279    0.0000 O   0  0
   -6.9870    3.2956    0.0000 C   0  0
   -8.1042    2.2947    0.0000 C   0  0
   -7.2957    4.7635    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.0973    0.8802    0.0000 H   0  3
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  9  8  1  6
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  1
 12 14  1  0
 14  9  1  0
 14 15  1  6
 15 16  1  0
 16 17  1  0
 16 18  2  0
  7 19  1  0
 19 20  2  0
 20  4  1  0
M  CHG  2   1  -1  21   1
M  END
> <name>
UTKinase_V5

> <id>
28771

> <plate>
Kinase v5-3

> <well>
G15

> <supplier_cmpd_name>
Anisomycin

> <ctcr_id>
932

> <supplier_cmpd_id>
S7409

> <smiles>
[Cl-].COc1ccc(C[C@@H]2NC[C@@H](O)[C@@H]2OC(C)=O)cc1.[H+]

> <pd_targets>
{LMGT2,HSF1,SLC2A1,REP,HT1,RORC}

> <pathway_gtopdb>
{Transporter,"Other cytosolic protein",Enzyme,"Transcription factor","Electrochemical transporter","Nuclear receptor","SLC superfamily of solute carriers","Nuclear hormone receptor subfamily 1","SLC02
 family of hexose and sugar alcohol transporters","Nuclear hormone receptor subfamily 1 group F","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Transporters,"Other protein targets",Receptors,"SLC superfamily of solute carriers","Anti-infective targets","Nuclear hormone receptors","SLC2 family of hexose and sugar alcohol transporters","Viral 
protein targets","1F. Retinoic acid-related orphans","Class I transporters","Coronavirus (CoV) proteins"}

> <pathway_reactome>
{"Cellular responses to external stimuli",Disease,"Gene expression (Transcription)","Cellular responses to stress","Disorders of transmembrane transporters","Infectious disease","RNA Polymerase II Tra
nscription","Cellular response to heat stress","SLC transporter disorders","SARS-CoV Infections","Generic Transcription Pathway","HSF1-dependent transactivation","Defective SLC2A1 causes GLUT1 deficie
ncy syndrome 1 (GLUT1DS1)","SARS-CoV-1 Infection","Transcriptional regulation by RUNX3","Attenuation phase","SARS-CoV-1 Genome Replication and Transcription","RUNX3 Regulates Immune Response and Cell 
Migration","Replication of the SARS-CoV-1 genome"}

> <broad_targets>
{NHP2L1,RPL10L,RPL11,RPL13A,RPL15,RPL19,RPL23,RPL23A,RPL26L1,RPL3,RPL37,RPL8,RSL24D1}

> <broad_moa>
{"DNA synthesis inhibitor"}

> <synonyms>
{UNII-6CQU2V295F,UNII6CQU2V295F,6CQU2V295F,22862-75-5,22862755,"Anisomycin, hydrochloride",NSC147340,"NSC 147340",MLS002702945,"ANISOMYCIN - HCL","ANISOMYCIN  HCL",SCHEMBL1003579,CHEMBL1998740,DTXSID0
0177403,NSC-147340,3,2-(p-methoxybenzyl)-,2(pmethoxybenzyl),3-acetate,3acetate,hydrochloride,cis-2,cis2,trans-3,trans3,4,T6758,Anisomycin}

> <pdid>
PD005847

> <targets>
{JNK,Antibiotic,Apoptosis,Bacterial,"DNA/RNA Synthesis"}

> <classes>
{Anti-infection,Apoptosis,Cell Cycle/DNA Damage,MAPK/ERK Pathway}

> <pubchem_cids>
{462385}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  1  0            999 V2000
    9.6577   -4.9951    0.0000 C   0  0
   11.1448   -5.1913    0.0000 C   0  0
   11.4178   -6.6662    0.0000 N   0  0
   10.0994   -7.3817    0.0000 N   0  0
    9.0370   -6.3477    0.0000 C   0  0
    7.5445   -6.5046    0.0000 C   0  0
    6.7945   -7.8036    0.0000 C   0  0
    5.3273   -7.4917    0.0000 S   0  0
    5.1894   -6.0109    0.0000 C   0  0
    6.5408   -5.3899    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    2.5909   -6.0056    0.0000 O   0  0
    3.8933   -3.7570    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0  1  0  0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 F   0  0
    1.2925   -3.7494    0.0000 C   0  0
   -0.0041   -2.9953    0.0000 N   0  0
    7.4046   -9.1739    0.0000 Cl  0  0
    9.8941   -8.8675    0.0000 C   0  0
    8.9324   -3.6822    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  1  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10  6  1  0
  9 11  1  0
 11 12  2  0
 11 13  1  0
 14 13  1  6
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 18 22  1  0
 14 23  1  0
 23 24  1  0
  7 25  1  0
  4 26  1  0
  1 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28772

> <plate>
Kinase v5-3

> <well>
G17

> <supplier_cmpd_name>
Afuresertib (GSK2110183)

> <ctcr_id>
11427

> <supplier_cmpd_id>
S7521

> <smiles>
c1(cnn(c1c1c(sc(c1)C(=O)N[C@@H](Cc1cc(ccc1)F)CN)Cl)C)Cl

> <pd_targets>
{AKT1,AKT2,AKT3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase AKT family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Akt (Protein kinase B","PKB) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Generic Transcription Pathway","Signaling by Insulin receptor","Tra
nscriptional Regulation by TP53","Insulin receptor signalling cascade","Regulation of TP53 Activity","IRS-mediated signalling","Regulation of TP53 Expression and Degradation","PI3K Cascade","Regulatio
n of TP53 Degradation","PKB-mediated events","PDE3B signalling"}

> <broad_targets>
{AKT1,AKT2,AKT3}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{Afuresertib,1047644-62-1,1047644621,GSK2110183C,"Afuresertib free base","Afuresertib (GSK2110183)",UNII-8739X25QI3,UNII8739X25QI3,"GSK 2110183C",ASB183,ASB-183,GSK-2110183C,"1047644-62-1 (free base)"
,"1047644621 (free base)",8739X25QI3,"Afuresertib HCl",GSK2110183,"Afuresertib (USAN:INN)",Afu,T1911}

> <pdid>
PD012538

> <targets>
{Akt,Akt1,Akt2,Akt3,PKC,ROCK}

> <classes>
{Cytoskeletal Signaling,PI3K/Akt/mTOR signaling,Cell Cycle/DNA Damage,Cytoskeleton,Epigenetics,PI3K/Akt/mTOR,Stem Cell/Wnt,TGF-beta/Smad}

> <pubchem_cids>
{46843057}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 25  0  0  0  0            999 V2000
   20.7995   -1.4656    0.0000 C   0  0
   19.4989   -0.7183    0.0000 C   0  0
   18.2002   -1.4705    0.0000 C   0  0
   16.8989   -0.7228    0.0000 C   0  0
   15.6002   -1.4751    0.0000 C   0  0
   14.2989   -0.7273    0.0000 C   0  0
   13.0002   -1.4796    0.0000 C   0  0
   11.6990   -0.7319    0.0000 C   0  0
   10.4003   -1.4841    0.0000 C   0  0
    9.0990   -0.7364    0.0000 C   0  0
    7.8003   -1.4887    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 C   0  0
   -1.2946   -3.7531    0.0000 O   0  0
    1.3032   -3.7490    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  1  0
 20 22  2  3
 22 16  1  0
 22 23  1  0
 23 24  1  0
 23 25  2  0
M  END
> <name>
UTKinase_V5

> <id>
28775

> <plate>
Kinase v5-3

> <well>
I21

> <supplier_cmpd_name>
Anacardic Acid

> <ctcr_id>
12485

> <supplier_cmpd_id>
S7582

> <smiles>
CCCCCCCCCCCCCCCC1=CC=CC(O)=C1C(O)=O

> <pd_targets>
{KAT8,KAT5,LOX1.1,SAE1,EP300,REP,KAT2B,LOX1.5,PLCG1,BID,MCL1,BAK1,BCL2L1}

> <pathway_gtopdb>
{"Epigenetic regulator",Enzyme,"Unclassified protein",Reader,Oxidoreductase,Writer,Transferase,"Methyl-lysine/arginine binding protein","Histone acetyltransferase",Chromodomain,"p300/CBP family","GNAT
 family","Other cytosolic protein","Ion channel","Other ion channel","Miscellaneous ion channel","Bcl-2 family"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Chromatin modifying enzymes","Bromodomain-containing proteins","Anti-infective targets","2.3.1.48 Histone acetyltransferases (HATs)","Non-enzymatic BRD containing pro
teins","Viral protein targets","Coronavirus (CoV) proteins","Glycerophospholipid turnover","Phosphoinositide-specific phospholipase C"}

> <pathway_reactome>
{"Chromatin organization","DNA Repair","Metabolism of proteins","Gene expression (Transcription)",Disease,"Chromatin modifying enzymes","DNA Double-Strand Break Repair","Post-translational protein mod
ification","RNA Polymerase II Transcription","Infectious disease","Diseases of signal transduction by growth factor receptors and second messengers","HATs acetylate histones","Homology Directed Repair
",SUMOylation,"Generic Transcription Pathway","SARS-CoV Infections","Signaling by NOTCH1 in Cancer","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Processing and activa
tion of SUMO","Transcriptional Regulation by TP53","SARS-CoV-2 Infection","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","HDR through Homologous Recombination (HRR)","SUMO is conjugated to E1 
(UBA2:SAE1)","Regulation of TP53 Activity","SARS-CoV-2 Genome Replication and Transcription","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Homologous DNA Pairing and Strand Exchange","Reg
ulation of TP53 Activity through Acetylation","Replication of the SARS-CoV-2 genome","Presynaptic phase of homologous DNA pairing and strand exchange","PI5P Regulates TP53 Acetylation","Leishmania inf
ection","Leishmania parasite growth and survival","Anti-inflammatory response favouring Leishmania parasite infection","FCGR3A-mediated IL10 synthesis"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"ANACARDIC ACID",16611-84-0,16611840,"6-Pentadecylsalicylic acid","6Pentadecylsalicylic acid","2-Hydroxy-6-pentadecylbenzoic acid","2Hydroxy6pentadecylbenzoic acid","2-Hydroxy-6-pentadecyl-benzoic ac
id","Hydroginkgolic acid","Ginkgolic acid C15:0","22:0-Anacardic acid","22:0Anacardic acid","(15:0)-Anacardic acid","(15:0)Anacardic acid","Benzoic acid",T6S2122,T6389,"Ginkgolic acid C13:0","Anacardi
c Acid"}

> <pdid>
PD016809

> <targets>
{"Histone Acetyltransferase","PCAF(p300/CBP-associated factor)","p300 histone acetylatransferase",p300/CBP}

> <classes>
{Chromatin/Epigenetic}

> <pubchem_cids>
{167551}

$$$$
UTKinase_V5
  SciTegic11012413002D

 62 69  0  0  1  0            999 V2000
    3.8794    3.7535    0.0000 O   0  0
    5.1821    3.0099    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0  1  0  0  0
    3.8939    0.7546    0.0000 O   0  0
    3.8990   -0.7455    0.0000 C   0  0  2  0  0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0  2  0  0  0
   -3.8978   -0.7496    0.0000 C   0  0  1  0  0  0
   -5.1981   -1.4975    0.0000 C   0  0
   -5.2005   -2.9975    0.0000 C   0  0
   -6.5007   -3.7455    0.0000 C   0  0
   -7.7985   -2.9934    0.0000 C   0  0
   -7.7962   -1.4934    0.0000 C   0  0
   -9.0963   -0.7436    0.0000 O   0  0
  -10.3962   -1.4938    0.0000 C   0  0  1  0  0  0
  -10.3934   -2.9939    0.0000 O   0  0
  -11.6911   -3.7463    0.0000 C   0  0  2  0  0  0
  -11.6852   -5.2471    0.0000 C   0  0
  -10.3837   -5.9929    0.0000 O   0  0
  -12.9915   -2.9987    0.0000 C   0  0  1  0  0  0
  -14.2891   -3.7512    0.0000 O   0  0
  -12.9943   -1.4987    0.0000 C   0  0  2  0  0  0
  -14.2947   -0.7512    0.0000 O   0  0
  -11.6967   -0.7463    0.0000 C   0  0  1  0  0  0
  -11.6995    0.7537    0.0000 O   0  0
   -6.4959   -0.7455    0.0000 C   0  0
   -6.4936    0.7545    0.0000 C   0  0
   -7.7914    1.5066    0.0000 O   0  0
   -5.1933    1.5025    0.0000 C   0  0
   -5.1910    3.0025    0.0000 C   0  0
   -6.4888    3.7545    0.0000 O   0  0
   -3.8907    3.7504    0.0000 C   0  0
   -2.5929    2.9983    0.0000 C   0  0
   -2.5953    1.4984    0.0000 C   0  0
   -3.8955    0.7504    0.0000 C   0  0
   -1.2904    3.7440    0.0000 C   0  0
   -1.2854    5.2440    0.0000 O   0  0
    0.0064    2.9901    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -3.8971   -5.2500    0.0000 C   0  0
   -2.5980   -6.0000    0.0000 C   0  0
   -1.2990   -5.2500    0.0000 C   0  0
    0.0000   -6.0000    0.0000 O   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    1.2991   -3.7500    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1953   -6.0031    0.0000 C   0  0
   -6.4956   -5.2554    0.0000 O   0  0
   -5.1932   -7.5031    0.0000 O   0  0
    5.2007   -1.4909    0.0000 C   0  0  2  0  0  0
    5.2059   -2.9909    0.0000 O   0  0
    6.4972   -0.7364    0.0000 C   0  0  1  0  0  0
    7.7988   -1.4819    0.0000 O   0  0
    6.4920    0.7636    0.0000 C   0  0  2  0  0  0
    7.7884    1.5180    0.0000 O   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  4  5  1  0
  5  6  1  1
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 12 11  1  1
 12 13  1  0
 13 14  1  1
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 20 19  1  1
 20 21  1  0
 21 22  1  0
 22 23  1  6
 23 24  1  0
 22 25  1  0
 25 26  1  1
 25 27  1  0
 27 28  1  6
 27 29  1  0
 29 20  1  0
 29 30  1  1
 18 31  2  0
 31 14  1  0
 31 32  1  0
 32 33  2  0
 32 34  1  0
 34 35  2  0
 35 36  1  0
 35 37  1  0
 37 38  2  0
 38 39  1  0
 39 40  2  0
 40 13  1  0
 40 34  1  0
 38 41  1  0
 41 42  1  0
 41 43  2  0
 12 44  1  0
 44 45  2  0
 45 46  1  0
 46 47  2  0
 47 48  1  0
 48 49  1  0
 48 50  2  0
 50 44  1  0
 50 51  1  0
 51 52  2  0
 51 53  1  0
 53  7  1  0
 53 11  2  0
 46 54  1  0
 54 55  1  0
 54 56  2  0
  5 57  1  0
 57 58  1  1
 57 59  1  0
 59 60  1  6
 59 61  1  0
 61  3  1  0
 61 62  1  1
M  END
> <name>
UTKinase_V5

> <id>
28777

> <plate>
Kinase v5-3

> <well>
I05

> <supplier_cmpd_name>
Sennoside B

> <ctcr_id>
878

> <supplier_cmpd_id>
S4018

> <smiles>
OC[C@H]1O[C@H](Oc2cccc3[C@H]([C@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O

> <pd_targets>
{AQP3,POL,REP,SERPINE1,USP2,HKDC1,L3MBTL1,TDP1,KDM4A}

> <pathway_gtopdb>
{Enzyme,Hydrolase,"Secreted protein",Transferase,"Epigenetic regulator",Protease,Reader,Eraser,"Cysteine protease","Methyl-lysine/arginine binding protein","Lysine demethylase","Cysteine protease CA c
lan","MBT domain","Jumonji domain-containing","Cysteine protease C19 family"}

> <pathway_chembl>
{"Ion channels","Other ion channels",Aquaporins,"Other protein targets","Anti-infective targets","Viral protein targets","Coronavirus (CoV) proteins",Enzymes,"Peptidases and proteinases","Chromatin mo
difying enzymes","CA: Cysteine (C) Peptidases","1.14.11.- Histone demethylases","C19: Ubiquitin-specific protease"}

> <pathway_reactome>
{"Transport of small molecules","Aquaporin-mediated transport","Passive transport by Aquaporins",Disease,"Gene expression (Transcription)","Infectious disease","RNA Polymerase II Transcription","SARS-
CoV Infections","Generic Transcription Pathway","SARS-CoV-2 Infection","Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer","SARS-CoV-2 Genome Replication and Transcription","SMAD2/SMAD3:SMAD4
 heterotrimer regulates transcription","Replication of the SARS-CoV-2 genome","DNA Repair","DNA Double-Strand Break Repair","Nonhomologous End-Joining (NHEJ)","DNA Double Strand Break Response","Trans
criptional Regulation by TP53","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","Regulation of TP53 Activity","Regulation of TP53 Expression 
and Degradation","Regulation of TP53 Activity through Methylation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Spectrum_001896,Spectrum001896,Spectrum-001896,"Spectrum 001896",SpecPlus_000129,SpecPlus000129,SpecPlus-000129,"SpecPlus 000129",KBioSS_002426,KBioSS002426,KBioSS-002426,"KBioSS 002426",DivK1c_00622
5,DivK1c006225,DivK1c-006225,"DivK1c 006225",SCHEMBL15216902,KBio1_001169,KBio1001169,KBio1-001169,"KBio1 001169",KBio2_002420,KBio2002420,KBio2-002420,"KBio2 002420",KBio2_004988,KBio2004988,KBio2-00
4988,"KBio2 004988",KBio2_007556,KBio2007556,KBio2-007556,"KBio2 007556",CCG-214771,CCG214771,1504080,"SENNOSIDE B"}

> <pdid>
PD000748

> <targets>
{PDGFR}

> <classes>
{cathartic}

> <pubchem_cids>
{6708563}

$$$$
UTKinase_V5
  SciTegic11012413002D

 45 51  0  0  0  0            999 V2000
   -1.2926    8.2353    0.0000 C   0  0
    0.0078    7.4877    0.0000 N   0  0
    1.3055    8.2401    0.0000 C   0  0
    2.6059    7.4926    0.0000 C   0  0
    2.6088    5.9925    0.0000 N   0  0
    1.3111    5.2402    0.0000 C   0  0
    0.0106    5.9877    0.0000 C   0  0
    3.9087    5.2425    0.0000 C   0  0
    5.2075    5.9929    0.0000 C   0  0
    6.5068    5.2432    0.0000 N   0  0
    6.5073    3.7432    0.0000 C   0  0
    7.8057    2.9905    0.0000 N   0  0
    7.8041    1.4897    0.0000 C   0  0
    6.5026    0.7438    0.0000 C   0  0
    6.4978   -0.7562    0.0000 C   0  0
    7.7945   -1.5103    0.0000 C   0  0
    9.0959   -0.7644    0.0000 N   0  0
   10.3926   -1.5185    0.0000 C   0  0
    9.1007    0.7356    0.0000 C   0  0
   10.4021    1.4814    0.0000 O   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    3.8984    0.7484    0.0000 C   0  0
    2.5995    1.4986    0.0000 O   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.8697    2.7526    0.0000 C   0  0
   -6.6176    1.4524    0.0000 C   0  0
    5.2084    2.9929    0.0000 C   0  0
    3.9091    3.7425    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  1  0
 19 13  1  0
 19 20  2  0
 15 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 22 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 21  1  0
 25 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  1  0
 36 38  2  0
 38 32  1  0
 38 39  1  0
 39 29  1  0
 39 40  2  0
 34 41  1  0
 41 42  1  0
 42 43  1  0
 43 41  1  0
 11 44  1  0
 44 45  2  0
 45  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28778

> <plate>
Kinase v5-3

> <well>
I07

> <supplier_cmpd_name>
RN486

> <ctcr_id>
13654

> <supplier_cmpd_id>
S7080

> <smiles>
CN1CCN(CC1)c1cnc(Nc2cc(cn(C)c2=O)c2c(CO)c(ccc2)n2ccc3cc(cc(F)c3c2=O)C2CC2)cc1

> <pd_targets>
{TEC,BTK,SLK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","STE protein kinase group","Tyrosine protein kinase Tec family","STE protein kinase STE20 family","STE protein kinase SLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","STE20 family","Non-recept
or tyrosine kinases (nRTKs)","SLK subfamily","Tec family"}

> <pathway_reactome>
{"Immune System",Disease,"Cytokine Signaling in Immune system","Infectious disease","Signaling by Interleukins","Leishmania infection",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Parasite infe
ction","Leishmania phagocytosis","FCGR3A-mediated phagocytosis"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{RN486,1242156-23-5,1242156235,RN-486,"RN 486",CHEMBL2057918,"compound 29 (PMID 22394077)",QCR-5,QCR5,GTPL8249,SCHEMBL1724904,C35H35FN6O3,DTXSID40677215,EX-A537,EXA537,HMS3741M17,BCP07289,BDBM50388189
,MFCD24682729,NSC781417,s7080,ZINC72319591,AKOS026750290,CCG-270209,CCG270209,CS-18,CS18,T1976}

> <pdid>
PD021552

> <targets>
{BTK}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{46908026}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 37  0  0  0  0            999 V2000
    4.6580    2.9476    0.0000 C   0  0
    3.1904    2.6376    0.0000 C   0  0
    2.7248    1.2135    0.0000 N   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -3.8056    3.8679    0.0000 C   0  0
   -3.3372    5.2929    0.0000 C   0  0
   -4.2146    6.5095    0.0000 C   0  0
   -1.8372    5.2877    0.0000 N   0  0
   -0.9513    6.4982    0.0000 C   0  0
   -1.3786    3.8595    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.6924   -4.0811    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.1047   -0.0031    0.0000 C   0  0
    5.8570    1.2946    0.0000 O   0  0
    5.8532   -1.3039    0.0000 N   0  0
    7.3541   -1.3070    0.0000 C   0  0
    8.5617   -2.0570    0.0000 C   0  0
    8.5617   -0.5570    0.0000 C   0  0
    5.1006   -2.6023    0.0000 C   0  0
    5.1419   -4.0233    0.0000 C   0  0
    3.8452   -3.2693    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  3  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  1  0
 15 17  1  0
 17 11  2  0
  9 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 21 23  1  0
 23  6  1  0
 23 18  2  0
  4 24  1  0
 24 25  2  0
 24 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 27  1  0
 26 30  1  0
 30 31  1  0
 31 32  1  0
 32 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28779

> <plate>
Kinase v5-3

> <well>
I09

> <supplier_cmpd_name>
BMS-911543

> <ctcr_id>
4090

> <supplier_cmpd_id>
S7144

> <smiles>
CCn1c(cc2c1nc(Nc3cc(C)n(C)n3)c4ncn(C)c24)C(=O)N(C5CC5)C6CC6

> <pd_targets>
{TYK2,JAK2,JAK1,JAK3,CYP3A4,CYP1A2,PDE4A,PDE4B,PDE4C,PDE4D}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450",Phosphodiesterase,"Protein Kinase","Cytochrome P450 family 3","Cytochrome P450 family 1","Phosphodiesterase 4","TK protein kinase group","Cytochrome P450 family 3A","C
ytochrome P450 family 1A","Phosphodiesterase 4A","Tyrosine protein kinase JakA family","Cytochrome P450 3A4","Cytochrome P450 1A1"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Cytochrome P450","Receptor kinases","CYP3 family","CYP1 family","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Immune System","Cell Cycle",Metabolism,"Cytokine Signaling in Immune system",Mitotic,"Metabolism of lipids","Biological oxidations","Interferon Signaling","Mitotic G1 phase and G1/S transition","Sig
naling by Interleukins","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","Interferon alpha/beta signaling","G1 Phase","Antiviral mechanism by IFN-
stimulated genes","Interleukin-2 family signaling","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Regulation of IFNA signaling","Cyclin D associated events in G1","
ISG15 antiviral mechanism","Interleukin-15 signaling","Biosynthesis of maresins",Xenobiotics,"Biosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2"}

> <broad_targets>
{}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{MS91154,BMS-911543,BMS911543,1271022-90-2,1271022902,"BMS 911543",UNII-7N03P021J8,UNII7N03P021J8,7N03P021J8,GTPL7954,SCHEMBL1512419,CHEMBL3545215,DTXSID00155403,HMS3747C07,AOB87390,BCP07258,EX-A1551,
EXA1551,BDBM50122318,MFCD22200575,NSC766821,NSC799366,s7144,AKOS027251175,"JAK2 INHIBIT",T6790,S7144}

> <pdid>
PD036139

> <targets>
{JAK}

> <classes>
{Epigenetics,JAK/STAT Signaling,Stem Cell/Wnt}

> <pubchem_cids>
{50922691}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  0  0            999 V2000
    5.2107    7.4939    0.0000 C   0  0
    5.2073    5.9939    0.0000 N   0  0
    3.9066    5.2468    0.0000 C   0  0
    3.9032    3.7468    0.0000 C   0  0
    5.2006    2.9938    0.0000 N   0  0
    6.5013    3.7410    0.0000 C   0  0
    6.5047    5.2410    0.0000 C   0  0
    5.1996    1.4930    0.0000 C   0  0
    3.9001    0.7439    0.0000 C   0  0
    3.8990   -0.7562    0.0000 C   0  0
    5.1976   -1.5070    0.0000 C   0  0
    6.4972   -0.7578    0.0000 C   0  0
    6.4982    0.7422    0.0000 C   0  0
    5.1998   -3.0078    0.0000 O   0  0
    6.5001   -3.7572    0.0000 C   0  0
    6.5023   -5.2572    0.0000 F   0  0
    7.7983   -3.0057    0.0000 F   0  0
    7.8001   -4.5055    0.0000 F   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.9095   -2.9665    0.0000 N   0  0
   -4.4013   -3.1233    0.0000 N   0  0
   -5.0114   -1.7530    0.0000 C   0  0
   -6.4775   -1.4442    0.0000 C   0  0
   -7.4798   -2.5602    0.0000 O   0  0
   -6.9433   -0.0184    0.0000 N   0  0
   -1.9091   -4.0818    0.0000 C   0  0
   -2.3746   -5.5086    0.0000 C   0  0
   -1.3730   -6.6252    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  1  0
 15 16  1  0
 15 17  1  0
 15 18  1  0
 10 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 23  1  0
 28 29  2  0
 29 20  1  0
 27 30  1  0
 30 31  1  0
 31 32  2  0
 32 26  1  0
 32 33  1  0
 33 34  2  0
 33 35  1  0
 30 36  1  0
 36 37  1  0
 37 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28780

> <plate>
Kinase v5-3

> <well>
I11

> <supplier_cmpd_name>
NMS-P937 (NMS1286937)

> <ctcr_id>
11624

> <supplier_cmpd_id>
S7255

> <smiles>
CN1CCN(CC1)c1cc(c(cc1)OC(F)(F)F)Nc1ncc2CCc3c(c2n1)n(nc3C(=O)N)CCO

> <pd_targets>
{PLK1,FLT3,MELK,PLK2,PLK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","TK protein kinase group","CAMK protein kinase group","Other protein kinase PLK family","Tyrosine protein kinase PDGFR family","CAMK protei
n kinase CAMK1 family","CAMK protein kinase MELK subfamily","Other protein kinase PLK2"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Other protein kinases","TK: Tyrosine kinase","CAMK-like (CAMKL)
 family","Polo-like kinase (PLK) family","Receptor tyrosine kinases (RTKs)","MELK subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Cell Cycle","Signal Transduction",Disease,"Gene expression (Transcription)",Mitotic,"Signaling by Receptor Tyrosine Kinases","Infectious disease","RNA Polymerase II Transcription","Mitotic G2-G2/M p
hases","Signaling by Insulin receptor","Leishmania infection","Generic Transcription Pathway","G2/M Transition","Insulin receptor signalling cascade","Leishmania parasite growth and survival","Transcr
iptional Regulation by TP53","Centrosome maturation","IRS-mediated signalling","Anti-inflammatory response favouring Leishmania parasite infection","Regulation of TP53 Activity","Loss of proteins requ
ired for interphase microtubule organization from the centrosome","PI3K Cascade","CD163 mediating an anti-inflammatory response","Regulation of TP53 Activity through Phosphorylation","Loss of Nlp from
 mitotic centrosomes"}

> <broad_targets>
{FLT3,PLK1,PLK2,PLK3}

> <broad_moa>
{"PLK inhibitor"}

> <synonyms>
{MSP93,NMS-1286937,NMS1286937,1034616-18-6,1034616186,NMS-P937,NMSP937,Onvansertib,"NMS-P937 (NMS1286937)","NMSP937 (NMS1286937)",UNII-67RM91WDHQ,UNII67RM91WDHQ,"Onvansertib free base",67RM91WDHQ,CHEM
BL1738758,PCM-075,PCM075,"Onvansertib (USAN)","NMS 1286937",GTPL7918,"NMS P937",SCHEMBL1228019,C24H27F3N8O3,HMS3653G0,T6247}

> <pdid>
PD012524

> <targets>
{PLK,PLK1,PLK2,PLK3,Apoptosis,"Polo-like Kinase (PLK)"}

> <classes>
{Cell Cycle/Checkpoint,Apoptosis,Cell Cycle/DNA Damage}

> <pubchem_cids>
{49792852}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  1  0            999 V2000
    5.1887   -6.0105    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0  2  0  0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
   -2.5795   -7.5040    0.0000 O   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5973    1.5031    0.0000 C   0  0
   -3.8976    0.7553    0.0000 O   0  0
   -2.5951    3.0039    0.0000 N   0  0
   -3.8933    3.7570    0.0000 C   0  0
   -3.8912    5.2578    0.0000 C   0  0
   -5.1876    6.0124    0.0000 C   0  0
   -5.1824    7.5124    0.0000 C   0  0
   -3.8808    8.2579    0.0000 C   0  0
   -3.8756    9.7586    0.0000 N   0  0
   -5.0848   10.6246    0.0000 C   0  0
   -4.6141   12.0488    0.0000 C   0  0
   -3.1141   12.0412    0.0000 N   0  0
   -2.6578   10.6123    0.0000 C   0  0
   -2.5844    7.5034    0.0000 C   0  0
   -2.5896    6.0034    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 12 11  1  1
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 12  1  0
 15 18  1  6
 10 19  2  0
 19  6  1  0
  9 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 28  1  0
 27 33  1  0
 33 34  2  0
 34 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28781

> <plate>
Kinase v5-3

> <well>
I13

> <supplier_cmpd_name>
UNC2881

> <ctcr_id>
12813

> <supplier_cmpd_id>
S7325

> <smiles>
CCCCNc1ncc(c(N[C@@H]2CC[C@H](CC2)O)n1)C(=O)NCc1ccc(n2ccnc2)cc1

> <pd_targets>
{TYRO3,MERTK,AXL}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Axl family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{Hemostasis,"Signal Transduction","Cell surface interactions at the vascular wall","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","VEGFA-VEGFR2 Pathway"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{UNC2881,1493764-08-1,1493764081,CHEMBL3093756,SCHEMBL16435501,SCHEMBL17167888,AOB6195,C25H33N7O2,HMS3653M12,HMS3747I07,BCP12436,EX-A2176,EXA2176,"UNC 2881",UNC-2881,UNC-2882,UNC2882,2784AH,BDBM504442
41,s7325,AKOS024464756,AKOS026750571,ZINC103239230,ZINC205861137,ZINC252586,T2629}

> <pdid>
PD010351

> <targets>
{"TAM Receptor",AXL,Mer,Tyro3}

> <classes>
{Tyrosine Kinase/Adaptors,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{71721525}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  0  0            999 V2000
    6.4396   -9.0101    0.0000 C   0  0
    4.9576   -8.7783    0.0000 C   0  0
    4.4162   -7.3785    0.0000 O   0  0
    2.9334   -7.1466    0.0000 C   0  0
    2.3903   -5.7483    0.0000 C   0  0
    3.3277   -4.5763    0.0000 N   0  0
    2.7822   -3.1780    0.0000 C   0  0
    3.7175   -2.0053    0.0000 N   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 N   0  0
    2.5242    2.0130    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
    0.0000    3.2286    0.0000 O   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.4523    2.0983    0.0000 C   0  0
   -3.8856    1.6561    0.0000 C   0  0
   -4.2194    0.1937    0.0000 C   0  0
   -3.1198   -0.8265    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 N   0  0
   -1.4008   -2.9088    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 N   0  0
    0.9077   -5.5197    0.0000 C   0  0
   -0.0316   -6.6892    0.0000 C   0  0
    0.5116   -8.0874    0.0000 C   0  0
    1.9941   -8.3161    0.0000 C   0  0
   -0.4281   -9.2575    0.0000 N   0  0
   -1.9110   -9.0312    0.0000 C   0  0
   -2.8485  -10.2022    0.0000 C   0  0
   -2.3031  -11.5996    0.0000 C   0  0
   -3.2405  -12.7706    0.0000 O   0  0
   -0.8202  -11.8259    0.0000 C   0  0
    0.1172  -10.6549    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 20 21  1  0
 21 22  1  0
 21 23  1  0
 23 10  1  0
 23 24  2  0
 24  7  1  0
  5 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28  4  1  0
 27 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 32 34  1  0
 34 35  1  0
 35 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28783

> <plate>
Kinase v5-3

> <well>
I17

> <supplier_cmpd_name>
XMD8-92

> <ctcr_id>
13669

> <supplier_cmpd_id>
S7525

> <smiles>
CCOc1c(Nc2ncc3n(C)c(=O)c4ccccc4n(C)c3n2)ccc(c1)N1CCC(O)CC1

> <pd_targets>
{BRD4,PLK4,DCLK2,MAPK7,TNK1}

> <pathway_gtopdb>
{"Epigenetic regulator",Enzyme,Reader,Kinase,Bromodomain,"Protein Kinase","Other protein kinase group","CAMK protein kinase group","CMGC protein kinase group","TK protein kinase group","Other protein 
kinase PLK family","CAMK protein kinase DCAMK1 family","CMGC protein kinase MAPK family","Tyrosine protein kinase Ack family","CMGC protein kinase ERK5"}

> <pathway_chembl>
{Enzymes,Receptors,"Chromatin modifying enzymes","Catalytic receptors","Kinases (EC 2.7.x.x)","Enzymatic bromodomain-containing proteins","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein
 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Bromodomain kinase (BRDK) family","Other protein kinases","DCAMKL family","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kin
ase","Polo-like kinase (PLK) family","ERK subfamily","Non-receptor tyrosine kinases (nRTKs)","Ack family"}

> <pathway_reactome>
{Disease,"Cell Cycle","Immune System","Infectious disease",Mitotic,"Innate Immune System","SARS-CoV Infections","Mitotic G2-G2/M phases","Toll-like Receptor Cascades","Potential therapeutics for SARS"
,"G2/M Transition","Toll Like Receptor 5 (TLR5) Cascade","Centrosome maturation","MyD88 cascade initiated on plasma membrane","Loss of proteins required for interphase microtubule organization from th
e centrosome","MAP kinase activation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{DCLK2,MAPK7,PLK4,TNK1}

> <broad_moa>
{"MAP kinase inhibitor"}

> <synonyms>
{MD89,XMD8-92,XMD892,1234480-50-2,1234480502,"XMD 8-92","XMD 892",CHEMBL1673046,CHEBI:60325,"Scaffold, B46","XMD 8-92 (free base)","XMD 892 (free base)",MLS003230939,SCHEMBL619295,GTPL8057,AOB6844,DTX
SID10676750,EX-A999,EXA999,HMS3295A13,HMS3653F13,BCP03605,ABP001068,BDBM50337134,MFCD18782742,s7525,ZINC646339,T1843}

> <pdid>
PD003257

> <targets>
{ERK,BMI-1,"Epigenetic Reader Domain"}

> <classes>
{Others,Epigenetics,MAPK/ERK Pathway,Stem Cell/Wnt}

> <pubchem_cids>
{46843772}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  1  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0  1  0  0  0
   -5.1953    1.5031    0.0000 O   0  0
   -5.1932    3.0039    0.0000 C   0  0
   -3.8929    3.7516    0.0000 O   0  0
   -6.4914    3.7570    0.0000 C   0  0
   -6.4915    5.2570    0.0000 C   0  0
   -7.7905    6.0070    0.0000 C   0  0
   -7.7905    7.5070    0.0000 O   0  0
   -9.0896    5.2570    0.0000 C   0  0
  -10.3886    6.0071    0.0000 O   0  0
   -9.0896    3.7570    0.0000 C   0  0
  -10.3886    3.0071    0.0000 O   0  0
   -7.7906    3.0070    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0  2  0  0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1968   -1.5004    0.0000 C   0  0
   -5.1993   -3.0005    0.0000 C   0  0
   -6.4995   -3.7484    0.0000 C   0  0
   -6.5019   -5.2484    0.0000 O   0  0
   -7.7973   -2.9964    0.0000 C   0  0
   -9.0976   -3.7443    0.0000 O   0  0
   -7.7950   -1.4964    0.0000 C   0  0
   -9.0928   -0.7443    0.0000 O   0  0
   -6.4947   -0.7484    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  6
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 14 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  1  0
 18 20  2  0
 20 12  1  0
  8 21  1  0
 21 22  1  0
 22 23  1  0
 23  6  1  0
 23 24  2  0
 24  2  1  0
 21 25  1  6
 25 26  2  0
 26 27  1  0
 27 28  1  0
 27 29  2  0
 29 30  1  0
 29 31  1  0
 31 32  1  0
 31 33  2  0
 33 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28784

> <plate>
Kinase v5-3

> <well>
L06

> <supplier_cmpd_name>
(-)-Epigallocatechin Gallate

> <ctcr_id>
1029

> <supplier_cmpd_id>
Se S2250

> <smiles>
Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4

> <pd_targets>
{PGD,CREBBP,HSPD1,HSPE1,RAD52,FABG,MET,MAPT,POS-1,DYRK1A,APP,KAT2B,REP,POL,FABI,BCL2,MMP14,POLB,ZWF1,RECQL,GAA,BACE1,TERT,PIN1,KAT5,TTR,GROES,GROL,STAT1,SQLE,MMP2,ELANE,TDP1,PKM,FASN,PTGES,CNR1,PSMB5,
FABZ,MEX-5,KMT2A,MEN1,EP300,TST,ATP2A1,CNR2,KDM4E,TGR,FFP,MAPK14,MMP7,ALD,DPP4,MAPKAPK5,ABCB1,NS3,DNMT1,PGAM1,HSP90AB1,APEX1,CYP3A4,HSD17B10,KCNH2,MAPK1,BLM,GALK1,ALDH1A1,ALOX15,USP2,HPGD}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Other cytosolic protein","Other nuclear protein","Transcription factor","Membrane receptor","Ion channel","Secreted protein","Unclassified protein",Transporter,Oxidored
uctase,Writer,Kinase,Transferase,Hydrolase,"Other ion channel",Protease,Isomerase,Reader,"Family A G protein-coupled receptor","Primary active transporter",Eraser,"Histone acetyltransferase","Protein 
Kinase","Miscellaneous ion channel","Metallo protease","Aspartic protease","Methyl-lysine/arginine binding protein","Serine protease","Small molecule receptor (family A GPCR)","Threonine protease",Bro
modomain,"P-type ATPase","Lysine demethylase","ATP-binding cassette","DNA methyltransferase","p300/CBP family","TK protein kinase group","CMGC protein kinase group","GNAT family","Bcl-2 family","Metal
lo protease MAM clan","Aspartic protease AA clan",Chromodomain,"Serine protease PA clan","Lipid-like ligand receptor (family A GPCR)","Threonine protease PBT clan","Calcium ATPase","Jumonji domain-con
taining","Serine protease SC clan","CAMK protein kinase group","ABCB subfamily","Tyrosine protein kinase Met family","CMGC protein kinase DYRK family","Metallo protease M10A subfamily","Aspartic prote
ase A1A subfamily","Serine protease S1A subfamily","Cannabinoid receptor","Threonine protease T1A subfamily","CMGC protein kinase MAPK family","Serine protease S9B subfamily","CAMK protein kinase MAPK
APK family","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase p38 subfamily","CAMK protein kinase MAPKAPK subfamily","Cytochrome P450","Voltage-gated ion channel","Cytochrome P450 family 3","
Potassium channels","Cysteine protease","Cytochrome P450 family 3A","Voltage-gated potassium channel","Cysteine protease CA clan","Cytochrome P450 3A4","Cysteine protease C19 family","CMGC protein kin
ase ERK1"}

> <pathway_chembl>
{"Other protein targets",Receptors,Enzymes,Transporters,"Bromodomain-containing proteins","Catalytic receptors","Kinases (EC 2.7.x.x)","Chromatin modifying enzymes","Anti-infective targets","B-cell ly
mphoma 2 (Bcl-2) protein family","Peptidases and proteinases","3.2.1.- Glycosidases","Peptidyl-prolyl cis/trans isomerases",Transthyretin,"Lanosterol biosynthesis pathway","2.7.1.40 Pyruvate kinases",
"2.3.1.-  Acyltransferases","Eicosanoid turnover","G protein-coupled receptors","P-type ATPases","ATP-binding cassette transporter family","2.1.1.- Methyltransferases","Non-enzymatic BRD containing pr
oteins","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","2.3.1.48 Histone acetyltransferases (HATs)","Viral protein targets","MA: Metallo (M) Peptidases","AA: Aspartic (A) Peptidase
s","PA: Serine (S) Peptidases","Prostaglandin synthases","Cannabinoid receptors","PB: Threonine (T) Peptidases","P2A P-type ATPases: Ca<sup>2+</sup>-ATPases","1.14.11.- Histone demethylases","SC: Seri
ne (S) Peptidases","CAMK: Calcium/calmodulin-dependent protein kinases","ABCB subfamily","TK: Tyrosine kinase","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Coronavir
us (CoV) proteins","M10: Matrix metallopeptidase","A1: Pepsin","S1: Chymotrypsin","T1: Proteasome","Mitogen-activated protein kinases (MAP kinases)","S9: Prolyl oligopeptidase","MAPK-Activated Protein
 Kinase (MAPKAPK) family","Receptor tyrosine kinases (RTKs)","Dyrk1 subfamily","p38 subfamily","MAPKAPK subfamily","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Heat shock proteins","
Ion channels","Cytochrome P450","Voltage-gated ion channels","CYP3 family","Potassium channels",Lipoxygenases,"CA: Cysteine (C) Peptidases","Voltage-gated potassium channels","C19: Ubiquitin-specific 
protease","ERK subfamily"}

> <pathway_reactome>
{Metabolism,"Gene expression (Transcription)","DNA Repair","Developmental Biology","Neuronal System","Cell Cycle","Immune System",Disease,"Extracellular matrix organization","Metabolism of proteins","
Signal Transduction",Hemostasis,"Metabolism of carbohydrates","RNA Polymerase II Transcription","DNA Double-Strand Break Repair","Nervous system development","Transmission across Chemical Synapses",Mi
totic,"Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","Infectious disease","Degradation of the extracellular matrix","Base Excision Repair","D
iseases of metabolism","Amyloid fiber formation","Chromosome Maintenance","Signaling by GPCR","Metabolism of lipids","Metabolism of amino acids and derivatives","Platelet homeostasis","Signaling by Nu
clear Receptors","Peptide hormone metabolism","Abacavir transport and metabolism","Post-translational protein modification","Pentose phosphate pathway","Generic Transcription Pathway","Homology Direct
ed Repair","Axon guidance","Neurotransmitter receptors and postsynaptic signal transmission","Mitotic G1 phase and G1/S transition","Toll-like Receptor Cascades","Signaling by NOTCH1 in Cancer","SARS-
CoV Infections","Nucleotide-binding domain","leucine rich repeat containing receptor (NLR) signaling pathways","Activation of Matrix Metalloproteinases","Resolution of Abasic Sites (AP sites)","Diseas
es of carbohydrate metabolism","Telomere Maintenance","GPCR downstream signalling","Signaling by FGFR in disease","Metabolism of steroids","Complement cascade","Nonhomologous End-Joining (NHEJ)","Gluc
ose metabolism","Fatty acid metabolism","Regulation of mitotic cell cycle","Sulfur amino acid metabolism","Platelet calcium homeostasis","ESR-mediated signaling","Incretin synthesis",secretion,"and in
activation","Abacavir transmembrane transport",SUMOylation,"Transcriptional Regulation by TP53","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Semaphorin interactions",
"Activation of NMDA receptors and postsynaptic events","G0 and Early G1","Toll Like Receptor 5 (TLR5) Cascade","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","SARS-CoV-2 Infection",Inflammasom
es,"Resolution of AP sites via the multiple-nucleotide patch replacement pathway","Glycogen storage diseases","Extension of Telomeres","G alpha (i) signalling events","Signaling by FGFR1 in disease","
Regulation of cholesterol biosynthesis by SREBP (SREBF)","EPH-Ephrin signaling","Regulation of Complement cascade",Glycolysis,"Arachidonic acid metabolism","APC/C-mediated degradation of cell cycle pr
oteins","Degradation of cysteine and homocysteine","Reduction of cytosolic Ca++ levels","Extra-nuclear estrogen signaling",Synthesis,"and inactivation of Glucagon-like Peptide-1 (GLP-1)","SUMO E3 liga
ses SUMOylate target proteins",Gluconeogenesis,"TP53 Regulates Transcription of Cell Death Genes","HDR through Single Strand Annealing (SSA)","Sema4D in semaphorin signaling","Post NMDA receptor activ
ation events","MyD88 cascade initiated on plasma membrane","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","SARS-CoV-2 Genome Replication and Transcription","The NLRP1 inflammasome","PCNA-De
pendent Long Patch Base Excision Repair","Glycogen storage disease type II (GAA)","Telomere Extension By Telomerase","Regulation of TP53 Activity","HDR through Homologous Recombination (HRR)","Visual 
phototransduction","FGFR1 mutant receptor activation","Activation of gene expression by SREBF (SREBP)","EPH-ephrin mediated repulsion of cells","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
,"Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Sulfide oxidation to sulfate","SUMOylation of DNA methylation proteins","TP53 Regulates Transcription of Genes Involved
 in Cytochrome C Release","Sema4D mediated inhibition of cell attachment and migration","Activation of AMPK downstream of NMDARs","TAK1 activates NFkB by phosphorylation and activation of IKKs complex
","Replication of the SARS-CoV-2 genome","Regulation of TP53 Activity through Acetylation","Homologous DNA Pairing and Strand Exchange","The canonical retinoid cycle in rods (twilight vision)","Signal
ing by cytosolic FGFR1 fusion mutants","APC/C:Cdc20 mediated degradation of mitotic proteins","MAP kinase activation","Regulation of TP53 Activity through Phosphorylation","PI5P Regulates TP53 Acetyla
tion","Presynaptic phase of homologous DNA pairing and strand exchange","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","MAPK targets/ Nuclear
 events mediated by MAP kinases","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Activation of the AP-1 family of transcription factors","Mitotic G2-G2/M phases","G2/M Transition","The role of
 GTSE1 in G2/M progression after G2 checkpoint","Muscle contraction","Cardiac conduction","Biological oxidations","Biosynthesis of specialized proresolving mediators (SPMs)","Branched-chain amino acid
 catabolism","Phase 3 - rapid repolarisation","Diseases of glycosylation","Phase I - Functionalization of compounds","Biosynthesis of DHA-derived SPMs","Diseases associated with glycosylation precurso
r biosynthesis","Ethanol oxidation","Biosynthesis of DPA-derived SPMs","Biosynthesis of maresins","Defective GALK1 can cause Galactosemia II (GALCT2)","Biosynthesis of DPAn-3 SPMs","Biosynthesis of D-
series resolvins","Biosynthesis of maresin-like SPMs","Biosynthesis of DPAn-3-derived protectins and resolvins","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation","ERK/MA
PK targets","ERKs are inactivated"}

> <broad_targets>
{ELANE,EP300,FASN,KAT2B,MMP14,MMP2}

> <broad_moa>
{"bacterial DNA gyrase inhibitor"}

> <synonyms>
{"(-)-Epigallocatechin gallate","()Epigallocatechin gallate",EGCG,"Epigallocatechin gallate",989-51-5,989515,"Epigallocatechin 3-gallate","Epigallocatechin 3gallate",Epigallocatechin-3-gallate,Epigall
ocatechin3gallate,"Tea catechin",(-)-Epigallocatechin-3-o-gallate,()Epigallocatechin3ogallate,Epigallocatechin-3-monogallate,Epigallocatechin3monogallate,Teavigo,"(-)-Epigallocatechol galla","()Epigal
locatechol galla",T3807,T2988,S2250,SAM001247031,210239,"(-)-Gallocatechin gallate","(-)-Epigallocatechin Gallate","epigallocatechin-3-monogallate
((-)-Epigallocatechin Gallate)",CPD000449288,EPIGALLOCATECHIN-3-MONOGALLATE}

> <pdid>
PD002148

> <targets>
{"DNA Methyltransferase",HER2,Telomerase,EGFR,"Fatty Acid Synthase",Autophagy,"Endogenous Metabolite",Ferroptosis,HIV,"Mitochondrial Metabolism","Reactive Oxygen Species"}

> <classes>
{Anti-infection,Apoptosis,Autophagy,Immunology/Inflammation,Metabolic Enzyme/Protease,NF-ºB}

> <pubchem_cids>
{65064}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 27  0  0  0  0            999 V2000
    5.1873   -7.5109    0.0000 O   0  0
    5.1894   -6.0109    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 O   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.6003    1.4978    0.0000 N   0  0
    2.6044    2.9986    0.0000 C   0  0
    3.9039    3.7478    0.0000 C   0  0
    5.2024    2.9970    0.0000 F   0  0
    3.9048    5.2478    0.0000 C   0  0
    2.6063    5.9987    0.0000 C   0  0
    2.6073    7.4987    0.0000 I   0  0
    1.3068    5.2495    0.0000 C   0  0
    1.3058    3.7495    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -0.3115    2.9665    0.0000 C   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -2.4133    1.7530    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  2  3
 12 13  1  0
 12 14  1  0
 14 15  2  3
 15 16  1  0
 15 17  1  0
 17 18  2  3
 18 11  1  0
  9 19  1  0
 19 20  1  0
 20 21  2  3
 21 22  1  0
 22 23  2  3
 23 19  1  0
 23 24  1  0
 24 25  2  3
 25  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28785

> <plate>
Kinase v5-3

> <well>
K19

> <supplier_cmpd_name>
GDC-0623

> <ctcr_id>
12738

> <supplier_cmpd_id>
S7553

> <smiles>
OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)N2C=NC=C2C=C1

> <pd_targets>
{KCNH2,MAP2K1}

> <pathway_gtopdb>
{"Ion channel",Enzyme,"Voltage-gated ion channel",Kinase,"Potassium channels","Protein Kinase","Voltage-gated potassium channel","STE protein kinase group","STE protein kinase STE7 family"}

> <pathway_chembl>
{"Ion channels",Enzymes,"Voltage-gated ion channels","Kinases (EC 2.7.x.x)","Potassium channels","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Voltage-gated potassium channels"
,"STE7 family"}

> <pathway_reactome>
{"Muscle contraction","Signal Transduction","Cardiac conduction","Signaling by Receptor Tyrosine Kinases","Phase 3 - rapid repolarisation","Signaling by NTRKs","Signaling by NTRK1 (TRKA)","Signalling 
to ERKs","Prolonged ERK activation events","Frs2-mediated activation"}

> <broad_targets>
{}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{DC062,GDC-0623,GDC0623,1168091-68-6,1168091686,"GDC 0623","RG 7421",UNII-HW67545I4Q,UNIIHW67545I4Q,G-868,G868,HW67545I4Q,RG-7420,RG7420,RG-7421,RG7421,GTPL9909,SCHEMBL1615104,CHEMBL3330650,CHEBI:1676
59,AOB87143,BCP28689,EX-A2060,EXA2060,BDBM50025226,MFCD25976760,NSC778590,NSC800998,s7553,ZINC43206,T6843}

> <pdid>
PD012548

> <targets>
{MEK,MEK1}

> <classes>
{MAPK}

> <pubchem_cids>
{42642654}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    5.1009    2.6017    0.0000 O   0  0
    5.8532    1.3040    0.0000 C   0  0
    5.1047    0.0031    0.0000 N   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    0.0102   -7.5017    0.0000 C   0  0
    1.3123   -8.2482    0.0000 N   0  0
    1.3199   -9.7482    0.0000 C   0  0
    2.6227  -10.4916    0.0000 C   0  0
    3.9180   -9.7351    0.0000 S   0  0
    3.8901  -11.2348    0.0000 O   0  0
    5.1951   -8.9483    0.0000 O   0  0
    3.9104   -8.2351    0.0000 C   0  0
    2.6076   -7.4917    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
    2.7248    1.2135    0.0000 N   0  0
    7.3541    1.3071    0.0000 C   0  0
    8.5617    2.0571    0.0000 C   0  0
    8.5617    0.5571    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  2  0
 20 23  1  0
 23 24  1  0
 24 17  1  0
 15 25  1  0
 25 26  2  0
 26 12  1  0
  7 27  2  0
 27  4  1  0
  2 28  1  0
 28 29  1  0
 29 30  1  0
 30 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28786

> <plate>
Kinase v5-3

> <well>
K21

> <supplier_cmpd_name>
Filgotinib (GLPG0634)

> <ctcr_id>
11530

> <supplier_cmpd_id>
S7605

> <smiles>
O=C(Nc1nn2c(cccc2c2ccc(CN3CCS(=O)(=O)CC3)cc2)n1)C1CC1

> <pd_targets>
{JAK1,GSC2,JAK2,TYK2,FLT4,CSF1R,JAK3,FLT3,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Ion channel",Kinase,Transferase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","TK protein kinase group","Voltage-gated potassium channel","Tyrosine 
protein kinase JakA family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Ion channels","Catalytic receptors","Voltage-gated ion channels","Receptor kinases","Potassium channels","TK: Tyrosine kinase","Voltage-gated potassium channels","Non-receptor tyrosine kin
ases (nRTKs)","Receptor tyrosine kinases (RTKs)","Janus kinase (JakA) family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor f
amily"}

> <pathway_reactome>
{"Immune System","Cell Cycle","Signal Transduction","Gene expression (Transcription)","Muscle contraction","Cytokine Signaling in Immune system",Mitotic,"Signaling by Receptor Tyrosine Kinases","RNA P
olymerase II Transcription","Cardiac conduction","Interferon Signaling","Mitotic G1 phase and G1/S transition","Signaling by VEGF","Generic Transcription Pathway","Signaling by Interleukins","Signalin
g by Insulin receptor","Phase 3 - rapid repolarisation","Antiviral mechanism by IFN-stimulated genes","G1 Phase","Interferon alpha/beta signaling","VEGF ligand-receptor interactions","Transcriptional 
Regulation by VENTX","Interleukin-2 family signaling","Insulin receptor signalling cascade","ISG15 antiviral mechanism","Cyclin D associated events in G1","Regulation of IFNA signaling","VEGF binds to
 VEGFR leading to receptor dimerization","Interleukin-15 signaling","IRS-mediated signalling","PI3K Cascade"}

> <broad_targets>
{JAK1,JAK2,JAK3,TYK2}

> <broad_moa>
{"JAK inhibitor"}

> <synonyms>
{SCHEMBL253559,"Filgotinib pound GLPG0643)","GS-6034 FREE BASE","GS6034 FREE BASE",1206101-20-3,1206101203,Filgotinib,GLPG0634,1206161-97-8,1206161978,GLPG-0634,UNII-3XVL385Q0M,UNII3XVL385Q0M,GPLG0634
,Filgotinib(GLPG0634),3XVL385Q0M,G146034,"Filgotinib (GLPG0634)","Filgotinib (USAN:INN)",Jyseleca,GL,T1929}

> <pdid>
PD010273

> <targets>
{JAK,JAK1,JAK2,JAK3,Tyk2}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors",Chromatin/Epigenetic,"JAK/STAT signaling","Stem Cells"}

> <pubchem_cids>
{49831257}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 24  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 N   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -7.7942    1.4999    0.0000 N   0  0
   -6.4952   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -7.7934   -1.5031    0.0000 C   0  0
   -9.0937   -0.7554    0.0000 O   0  0
   -7.7912   -3.0031    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  2  0
 15  9  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18  7  1  0
 18 19  2  0
 19  4  1  0
 13 20  1  0
 20 21  1  0
 20 22  2  0
M  END
> <name>
UTKinase_V5

> <id>
28787

> <plate>
Kinase v5-3

> <well>
K03

> <supplier_cmpd_name>
Amlexanox

> <ctcr_id>
533

> <supplier_cmpd_id>
S3648

> <smiles>
CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(O)=O

> <pd_targets>
{KDM4E,PYK,RORC,TBK1,IKBKE,GAA,PKM,RAB9A,ALD,NPC1,GPR35,ABCC4,PDE4A,PDE4B,PDE4C,PDE4D,S100A12,S100A13,IL3,FGF1}

> <pathway_gtopdb>
{"Epigenetic regulator",Enzyme,"Transcription factor",Transporter,"Membrane receptor","Secreted protein",Eraser,Transferase,"Nuclear receptor",Kinase,Hydrolase,"Family A G protein-coupled receptor","P
rimary active transporter",Phosphodiesterase,"Lysine demethylase","Nuclear hormone receptor subfamily 1","Protein Kinase","Small molecule receptor (family A GPCR)","ATP-binding cassette","Phosphodiest
erase 4","Jumonji domain-containing","Nuclear hormone receptor subfamily 1 group F","Other protein kinase group","Carboxylic acid receptor","ABCC subfamily","Phosphodiesterase 4A","Nuclear hormone rec
eptor subfamily 1 group F member 3","Other protein kinase IKK family","Kynurenic acid receptor"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Chromatin modifying enzymes","Nuclear hormone receptors","Catalytic receptors","3.2.1.- Glycosidases","2.7.1.40 Pyruvate kinases","SLC superfamily of solute carriers",
"G protein-coupled receptors","ATP-binding cassette transporter family","1.14.11.- Histone demethylases","1F. Retinoic acid-related orphans","Receptor kinases","SLC65 NPC-type cholesterol transporters
","Orphan and other 7TM receptors","ABCC subfamily","Other protein kinases","Class A Orphans","IKK family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System",Disease,Metabolism,"Signal Transduction","Transport of small molecules",Hemostasis,"RNA Polymerase II Transcription","Innate Immune System","Diseases
 of metabolism","Metabolism of carbohydrates","Signaling by Rho GTPases","Plasma lipoprotein assembly",remodeling,"and clearance","Signaling by GPCR","Platelet activation","signaling and aggregation",
"Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","Toll-like Receptor Cascades","Diseases of carbohydrate metabolism","Glucose metaboli
sm","Rho GTPase cycle","Plasma lipoprotein clearance","GPCR ligand binding","Response to elevated platelet cytosolic Ca2+","Signaling by FGFR in disease","Transcriptional regulation by RUNX3","Toll Li
ke Receptor 4 (TLR4) Cascade","Glycogen storage diseases",Glycolysis,"RHOBTB GTPase Cycle","LDL clearance","Class A/1 (Rhodopsin-like receptors)","Platelet degranulation","Toll Like Receptor 5 (TLR5) 
Cascade","Transcriptional regulation by RUNX1","Signaling by FGFR3 in disease","RUNX3 Regulates Immune Response and Cell Migration","MyD88-independent TLR4 cascade","Glycogen storage disease type II (
GAA)","RHOBTB3 ATPase cycle","MyD88 cascade initiated on plasma membrane","RUNX1 regulates transcription of genes involved in interleukin signaling","Signaling by FGFR3 point mutants in cancer","TRIF(
TICAM1)-mediated TLR4 signaling","TAK1 activates NFkB by phosphorylation and activation of IKKs complex","FGFR3 mutant receptor activation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Sign
aling by activated point mutants of FGFR3"}

> <broad_targets>
{FGF1,IL3,PDE4A,PDE4B,PDE4C,PDE4D,S100A12,S100A13}

> <broad_moa>
{"histamine receptor modulator"}

> <synonyms>
{amlexanox,68302-57-8,68302578,Amoxanox,Aphthasol,"2-Amino-7-isopropyl-5-oxo-5H-chromeno(2,3-b)pyridine-3-carboxylic acid","2Amino7isopropyl5oxo5Hchromeno(2,3b)pyridine3carboxylic acid",Amlenanox,"Aml
exanoxum (Latin)",AA-673,AA673,"Amlexanoxo (Spanish)",Amlexanoxo,Amlexanoxum,"CHX 3673","AA 673",CHX-3673,CHX3673,UNII-BRL1C2459K,UNIIBRL1C2459K,2,T1639,SAM001246669,Amlexanox,CPD000466352}

> <pdid>
PD001296

> <targets>
{"Immunology & Inflammation related",IKK}

> <classes>
{NF-ºB}

> <pubchem_cids>
{2161}

$$$$
UTKinase_V5
  SciTegic11012413002D

 15 16  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    2.6060   -2.9986    0.0000 C   0  0
    3.9075   -3.7444    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  8 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15  6  1  0
 15 11  1  0
M  END
> <name>
UTKinase_V5

> <id>
28788

> <plate>
Kinase v5-3

> <well>
K05

> <supplier_cmpd_name>
Trapidil

> <ctcr_id>
3751

> <supplier_cmpd_id>
S4736

> <smiles>
CCN(CC)c1cc(C)nc2ncnn12

> <pd_targets>
{MAPK1,LMNA,CYP1A2,PDGFRB,PDE10A,PDE11A,PDE1A,PDE1B,PDE1C,PDE2A,PDE3A,PDE3B,PDE4A,PDE4B,PDE4C,PDE4D,PDE5A,PDE6A,PDE6B,PDE6C,PDE7A,PDE7B,PDE8A,PDE8B,PDE9A}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein",Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 1","CMGC protein kinase group","Cytochrome P450 family 1A","TK protein kinase group","CMGC protein kin
ase MAPK family","Cytochrome P450 1A1","Tyrosine protein kinase PDGFR family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Cytochrome P450","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP1 family","Receptor kinases","Mitogen-activated protein kinases (M
AP kinases)","TK: Tyrosine kinase","ERK subfamily","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Immune System","Cell Cycle",Metabolism,"Signal Transduction","Innate Immune System",Mitotic,"Biological oxidations","Intracellular signaling by second messengers","Toll-like Receptor Cascades","M Ph
ase","Phase I - Functionalization of compounds","PIP3 activates AKT signaling","Toll Like Receptor 5 (TLR5) Cascade","Mitotic Metaphase and Anaphase","Cytochrome P450 - arranged by substrate type","Ne
gative regulation of the PI3K/AKT network","MyD88 cascade initiated on plasma membrane","Mitotic Anaphase",Xenobiotics,PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","MAP kinase activation","Nuclear
 Envelope (NE) Reassembly","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAPK targets/ Nuclear events mediated by MAP kinases","Initiation of Nuclear Envelope (NE) Reformation","
ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{PDGFRA}

> <broad_moa>
{"PDGFR tyrosine kinase receptor inhibitor"}

> <synonyms>
{trapidil,15421-84-8,15421848,Rocornal,Trapymin,Avantrin,Trapymine,"N,N-diethyl-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidin-7-amine","N,Ndiethyl5methyl(1,2,4)triazolo(1,5a)pyrimidin7amine","AR 12008",UNI
I-EYG5Y6355E,UNIIEYG5Y6355E,AR-12008,AR12008,"(1,2,4)Triazolo(1,5-a)pyrimidin-7-amine, N,N-diethyl-5-methyl-","(1,2,4)Triazolo(1,5a)pyrimidin7amine, N,Ndiethyl5methyl",7-Diethylamino-5-methyl-,7Diethy
lamino5methyl,T0080,Prestw-1012,Trapidil}

> <pdid>
PD008972

> <targets>
{PDGFR}

> <classes>
{}

> <pubchem_cids>
{5531}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    2.5875   -5.9994    0.0000 C   0  0
    3.8888   -5.2533    0.0000 N   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 N   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.1882    2.6401    0.0000 N   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    6.4978   -0.7562    0.0000 N   0  0
    6.4979    0.7438    0.0000 C   0  0
    7.7969    1.4938    0.0000 C   0  0
    9.0959    0.7438    0.0000 C   0  0
    9.0960   -0.7562    0.0000 C   0  0
    7.7969   -1.5062    0.0000 C   0  0
    7.7970   -3.0062    0.0000 C   0  0
    7.8000    2.9947    0.0000 C   0  0
    6.5023    3.7469    0.0000 O   0  0
    9.1008    3.7432    0.0000 N   0  0
    9.1039    5.2441    0.0000 C   0  0
   10.4029    5.9941    0.0000 C   0  0
   10.4030    7.4941    0.0000 C   0  0
    9.1039    8.2442    0.0000 C   0  0
    7.8049    7.4942    0.0000 C   0  0
    7.8049    5.9942    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  7  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 16 17  1  0
 17 12  1  0
 17 18  2  0
 18  9  1  0
  5 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 19  1  0
 24 25  1  0
 21 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28789

> <plate>
Kinase v5-3

> <well>
K07

> <supplier_cmpd_name>
GSK2334470

> <ctcr_id>
872

> <supplier_cmpd_id>
S7087

> <smiles>
CNc1nc(cc(n1)c2ccc3c(N)n[nH]c3c2)N4CC(CCC4C)C(=O)NC5CCCCC5

> <pd_targets>
{AURKA,PDPK1,ROCK1,PIK3CG,AURKB}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","Other protein kinase group","AGC protein kinase group","Other protein kinase AUR family","AGC protein kinase PDK1 subfamily","AGC protein kinase DMPK famil
y","AGC protein kinase ROCK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","Lipid modifying kinases","Other protein kinases","PDK1 family","DMPK family
",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Aurora kinase (Aur) family","Rho kinase"}

> <pathway_reactome>
{"Gene expression (Transcription)","Developmental Biology",Metabolism,"Cell Cycle","RNA Polymerase II Transcription","Nervous system development","Metabolism of lipids",Mitotic,"Generic Transcription 
Pathway","Axon guidance","Phospholipid metabolism","M Phase","Transcriptional Regulation by TP53","Semaphorin interactions","PI Metabolism","Mitotic Metaphase and Anaphase","Regulation of TP53 Activit
y","Sema4D in semaphorin signaling","Synthesis of PIPs at the plasma membrane","Mitotic Anaphase","Regulation of TP53 Activity through Phosphorylation","Regulation of TP53 Expression and Degradation",
"Sema4D induced cell migration and growth-cone collapse","Separation of Sister Chromatids","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HMS3652N22,HMS3672E07,HMS3743G15,AKOS026750441,NCGC00387840-02,NCGC0038784002,AK547119,DA-33594,DA33594,FT-0696643,FT0696643,S7087,GSK2334470}

> <pdid>
PD003284

> <targets>
{PDK,PDK-1}

> <classes>
{}

> <pubchem_cids>
{75151153}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 36  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.5625    0.0216    0.0000 C   0  0
    3.8615   -0.7286    0.0000 O   0  0
    2.5631    1.5224    0.0000 C   0  0
    3.8627    2.2731    0.0000 C   0  0
    3.8634    3.7739    0.0000 C   0  0
    5.1612    4.5261    0.0000 C   0  0
    5.1588    6.0261    0.0000 C   0  0
    3.8585    6.7740    0.0000 C   0  0
    3.8530    8.2748    0.0000 O   0  0
    2.5517    9.0209    0.0000 C   0  0
    2.5607    6.0219    0.0000 C   0  0
    2.5631    4.5219    0.0000 C   0  0
    6.4589    6.7759    0.0000 O   0  0
    7.7580    6.0262    0.0000 C   0  0
    1.2628   -2.2303    0.0000 C   0  0
   -0.0366   -2.9798    0.0000 O   0  0
    2.5620   -2.9817    0.0000 C   0  0
    2.5618   -4.4825    0.0000 C   0  0
    3.8610   -5.2339    0.0000 C   0  0
    3.8630   -6.7340    0.0000 C   0  0
    5.1630   -7.4823    0.0000 C   0  0
    6.4611   -6.7306    0.0000 C   0  0
    6.4592   -5.2306    0.0000 C   0  0
    5.1591   -4.4823    0.0000 C   0  0
    7.7634   -7.4767    0.0000 O   0  0
    9.0604   -6.7231    0.0000 C   0  0
    5.1619   -8.9831    0.0000 O   0  0
    3.8627   -9.7329    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  1  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 14 17  1  0
 17 18  2  0
 18 11  1  0
 13 19  1  0
 19 20  1  0
  1 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 28 31  1  0
 31 32  1  0
 27 33  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28791

> <plate>
Kinase v5-3

> <well>
K11

> <supplier_cmpd_name>
FLLL32

> <ctcr_id>
11542

> <supplier_cmpd_id>
S7259

> <smiles>
C1(CCCCC1)(C(=O)/C=C/c1cc(c(OC)cc1)OC)C(=O)/C=C/c1cc(c(cc1)OC)OC

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{FLLL32,1226895-15-3,1226895153,CHEMBL2172012,"FLLL-32; FLLL 32","FLLL32; FLLL 32",SCHEMBL10054093,"(2E,2'E)-1,1'-cyclohexylidenebis(3-(3,4-dimethoxyphenyl)-2-propen-1-one)","(2E,2'E)1,1'cyclohexylide
nebis(3(3,4dimethoxyphenyl)2propen1one)",BCP28141,EX-A1096,EXA1096,MFCD27976793,s7259,ZINC95557239,CCG-269394,CCG269394,NCGC00481557-01,NCGC0048155701,AC-33050,AC33050,BS-14678,BS14678,QC-11753,QC1175
3,T6838}

> <pdid>
PD021528

> <targets>
{JAK,JAK2,Apoptosis,STAT}

> <classes>
{Angiogenesis,Chromatin/Epigenetic,JAK/STAT signaling,Stem Cells,Apoptosis,Epigenetics,JAK/STAT Signaling,Stem Cell/Wnt}

> <pubchem_cids>
{68019246}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 37  0  0  0  0            999 V2000
    6.4643   -9.7605    0.0000 C   0  0
    6.4719   -8.2606    0.0000 N   0  0
    7.7747   -7.5171    0.0000 C   0  0
    7.7822   -6.0171    0.0000 C   0  0
    6.4870   -5.2605    0.0000 N   0  0
    6.4915   -3.7597    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.1884   -2.6409    0.0000 C   0  0
   -4.6234   -3.0602    0.0000 C   0  0
   -4.9781   -4.5176    0.0000 C   0  0
   -3.8933   -5.5536    0.0000 C   0  0
   -3.9374   -7.0521    0.0000 N   0  0
   -2.5250   -7.5572    0.0000 C   0  0
   -1.6082   -6.3700    0.0000 C   0  0
   -2.4537   -5.1320    0.0000 C   0  0
   -2.0990   -3.6745    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.1842   -6.0040    0.0000 C   0  0
    5.1766   -7.5040    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 10 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 23  1  0
 27 28  2  0
 28 20  1  0
 19 29  1  0
 29 16  1  0
 29 30  2  0
 30 13  1  0
  5 31  1  0
 31 32  1  0
 32  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28792

> <plate>
Kinase v5-3

> <well>
K13

> <supplier_cmpd_name>
URMC-099

> <ctcr_id>
11594

> <supplier_cmpd_id>
S7343

> <smiles>
CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1

> <pd_targets>
{MAP3K2,IGF1R,MAPK8,ROCK1,DLK1,MAP3K10,CDK1,SGK1,ROCK2,ABL1,CYP3A4,MAP3K9,MAPK14,NTRK2,FLT3,SYK,LCK,PRKAA1,PRKAA2,PRKAB1,PRKAB2,PRKAG1,PRKAG2,PRKAG3,AURKB,MAP3K11,FLT1,LRRK2,ZAP70,MAPK1,MET,AURKC,CHUK
,AURKA,SRC,INSR,DAPK3,CDK2,IKBKB,NTRK1,KCNH2,SRPK2,CDKL2}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Ion channel",Kinase,"Cytochrome P450","Voltage-gated ion channel","Protein Kinase","Cytochrome P450 family 3","Potassium channels","STE protein kinase group","TK protei
n kinase group","CMGC protein kinase group","AGC protein kinase group","TKL protein kinase group","Cytochrome P450 family 3A","CAMK protein kinase group","Other protein kinase group","Voltage-gated po
tassium channel","STE protein kinase STE11 family","Tyrosine protein kinase InsR family","CMGC protein kinase MAPK family","AGC protein kinase DMPK family","TKL protein kinase MLK family","CMGC protei
n kinase CDK family","AGC protein kinase SGK family","Tyrosine protein kinase Abl family","Cytochrome P450 3A4","Tyrosine protein kinase Trk family","Tyrosine protein kinase PDGFR family","Tyrosine pr
otein kinase Syk family","Tyrosine protein kinase Src family","CAMK protein kinase CAMK1 family","Other protein kinase AUR family","Tyrosine protein kinase VEGFR family","TKL protein kinase LRRK famil
y","Tyrosine protein kinase Met family","Other protein kinase IKK family","CAMK protein kinase DAPK family","CMGC protein kinase SRPK family","CMGC protein kinase CDKL family","STE protein kinase MEKK
2","CMGC protein kinase JNK subfamily","AGC protein kinase ROCK subfamily","TKL protein kinase MLK subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase p38 subfamily","CAMK protein kin
ase AMPK subfamily","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","Kinases (EC 2.7.x.x)","Catalytic receptors","Cytochrome P450","Voltage-gated ion channels","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Rece
ptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: Containing PKA",PKG,"PKC families","CYP3 family","CAMK: Calcium/calmodulin-dependent protein kinases","Potassium channels","STE11 fa
mily","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","DMPK family","TKL: Tyrosine kinase-like","Cyclin-dependent kinase (CDK) family","SGK family","Other protein kinases","Dea
th-associated kinase (DAPK) family","Voltage-gated potassium channels","SRPK family","Cyclin-dependent kinase-like (CDKL) family","Receptor tyrosine kinases (RTKs)","JNK subfamily","Rho kinase","Mixed
 Lineage Kinase (MLK) family","CDK1 subfamily","Non-receptor tyrosine kinases (nRTKs)","p38 subfamily","Aurora kinase (Aur) family","Leucine-rich repeat kinase (LRRK) family","ERK subfamily","IKK fami
ly","Type II RTKs: Insulin receptor family","MLK subfamily","Abl family","Type VII RTKs: Neurotrophin receptor/Trk family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Syk family","Src fami
ly","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Developmental Biology","Cell Cycle","Gene expression (Transcription)",Disease,Metabolism,"Programmed Cell Death","Muscle contraction","Signaling by Receptor Tyr
osine Kinases","Innate Immune System","Nervous system development","Signaling by NOTCH",Mitotic,"RNA Polymerase II Transcription","Infectious disease","Metabolism of lipids","Diseases of signal transd
uction by growth factor receptors and second messengers","Signaling by Non-Receptor Tyrosine Kinases","Adaptive Immune System","Intracellular signaling by second messengers",Apoptosis,"Cardiac conduct
ion","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Toll-like Receptor Cascades","Axon guidance","Signaling by NOTCH1","Regulation of mitotic cell cycle","Generic Transcription P
athway","Leishmania infection","Biosynthesis of specialized proresolving mediators (SPMs)","Signaling by NTRKs","Signaling by Insulin receptor","HIV Infection","M Phase","Oncogenic MAPK signaling","Si
gnaling by VEGF","Signaling by PTK6","TCR signaling","PIP3 activates AKT signaling","Caspase activation via extrinsic apoptotic signalling pathway","Phase 3 - rapid repolarisation","IGF1R signaling ca
scade","Toll Like Receptor 5 (TLR5) Cascade","Semaphorin interactions","Activated NOTCH1 Transmits Signal to the Nucleus","APC/C-mediated degradation of cell cycle proteins","Transcriptional Regulatio
n by TP53","Parasite infection","Biosynthesis of DHA-derived SPMs","Signaling by NTRK1 (TRKA)","Insulin receptor signalling cascade","Leishmania parasite growth and survival","Host Interactions of HIV
 factors","Mitotic Metaphase and Anaphase","Signaling by RAS mutants","VEGF ligand-receptor interactions","PTK6 promotes HIF1A stabilization","Generation of second messenger molecules","Toll Like Rece
ptor 4 (TLR4) Cascade","Negative regulation of the PI3K/AKT network","Caspase activation via Dependence Receptors in the absence of ligand","IRS-related events triggered by IGF1R","MyD88 cascade initi
ated on plasma membrane","Sema4D in semaphorin signaling","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity","Leishmania phagocytosis","Biosyn
thesis of maresins","Activation of TRKA receptors","IRS-mediated signalling","Anti-inflammatory response favouring Leishmania parasite infection","The role of Nef in HIV-1 replication and disease path
ogenesis","Mitotic Anaphase","Signaling downstream of RAS mutants","VEGF binds to VEGFR leading to receptor dimerization","MyD88-independent TLR4 cascade","Signalling to ERKs",PI5P,"PP2A and IER3 Regu
late PI3K/AKT Signaling","MAP kinase activation","Sema4D induced cell migration and growth-cone collapse","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Expression and Degr
adation","FCGR3A-mediated phagocytosis","Biosynthesis of maresin-like SPMs","NGF-independant TRKA activation","PI3K Cascade","FCGR3A-mediated IL10 synthesis","Nef-mediates down modulation of cell surf
ace receptors by recruiting them to clathrin adapters","Separation of Sister Chromatids","Sema4D mediated inhibition of cell attachment and migration","TRIF(TICAM1)-mediated TLR4 signaling","Regulatio
n of TP53 Activity through Phosphorylation","Signalling to RAS","Prolonged ERK activation events","MAPK targets/ Nuclear events mediated by MAP kinases","APC:Cdc20 mediated degradation of cell cycle p
roteins prior to satisfation of the cell cycle checkpoint","Regulation of TP53 Degradation","Nef Mediated CD4 Down-regulation","IKK complex recruitment mediated by RIP1","p38MAPK events","ARMS-mediate
d activation","Activation of the AP-1 family of transcription factors","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{CDKL2,DAPK3,FLT3,LRRK2,MAP3K10,MAP3K11,MAP3K2,MAP3K9,SRPK2}

> <broad_moa>
{"mixed lineage kinase inhibitor"}

> <synonyms>
{RMC09,HMS3674I17,BCP11155,URMC-099,URMC099,1229582-33-5,1229582335,CHEMBL2436978,C27H27N5,"compound 1 (PMID 24044867)",SCHEMBL722076,GTPL8106,"URMC 099;URMC099",SYN1211,EX-A1276,EXA1276,BDBM50441567,
MFCD28168077,s7343,ZINC68243575,CCG-268902,CCG268902,NCGC00386408-03,NCGC0038640803,AC-33141,AC33141,AS-16339,AS16339,DA-,DA,T6057}

> <pdid>
PD003213

> <targets>
{LRRK2,"Aurora A","Aurora B","Aurora C",Abl1,CDK1,CDK2,c-Met,DLK,IGF-1R,"Insulin Receptor",MEKK2,MLK1,MLK2,MLK3,ROCK1,ROCK2,SGK,SGK1,Lck,Syk,TrkA,TrkB,VEGFR1/FLT1,Autophagy,"Mixed Lineage Kinase"}

> <classes>
{Cell Cycle/Checkpoint,Angiogenesis,Autophagy,DNA Damage/DNA Repair,MAPK,Metabolism,Tyrosine Kinase/AdaptorsChromatin/EpigeneticCytoskeletal SignalingStem Cells,MAPK/ERK Pathway}

> <pubchem_cids>
{54764565}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 30  0  0  0  0            999 V2000
    8.5188  -12.2439    0.0000 I   0  5
    5.4020  -25.9871    0.0000 C   0  0
    6.0188  -24.6197    0.0000 C   0  0
    5.1434  -23.4007    0.0000 C   0  0
    5.7605  -22.0326    0.0000 C   0  0
    4.8851  -20.8136    0.0000 C   0  0
    5.5023  -19.4455    0.0000 C   0  0
    4.6269  -18.2264    0.0000 C   0  0
    5.2441  -16.8584    0.0000 C   0  0
    4.3686  -15.6393    0.0000 C   0  0
    4.9858  -14.2713    0.0000 C   0  0
    4.1104  -13.0522    0.0000 C   0  0
    4.7276  -11.6841    0.0000 C   0  0
    3.8522  -10.4651    0.0000 C   0  0
    4.4693   -9.0970    0.0000 C   0  0
    3.5939   -7.8779    0.0000 C   0  0
    4.2111   -6.5099    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    1.8372   -5.2877    0.0000 C   0  0
    1.3786   -3.8595    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  3
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8056   -3.8679    0.0000 C   0  0
    5.2311   -3.4009    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 21 29  2  0
 29 18  1  0
 29 30  1  0
M  CHG  2   1  -1  21   1
M  END
> <name>
UTKinase_V5

> <id>
28793

> <plate>
Kinase v5-3

> <well>
K15

> <supplier_cmpd_name>
NH125

> <ctcr_id>
1996

> <supplier_cmpd_id>
S7436

> <smiles>
[I-].CCCCCCCCCCCCCCCCn1cc[n+](Cc2ccccc2)c1C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NH125,278603-08-0,278603080,"eEF-2 Kinase Inhibitor, NH125","eEF2 Kinase Inhibitor, NH125","1-Benzyl-3-cetyl-2-methylimidazolium iodide","1Benzyl3cetyl2methylimidazolium iodide","NH 125",nh-125,nh125
,"1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide","1Hexadecyl2methyl3(phenylmethyl)1Himidazolium iodide",MFCD07370143,"3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide","3Benzyl1hex
adecyl2methyl1Himidazol3ium iodide",CH,"EMD 324515",3439,324515}

> <pdid>

> <targets>
{"eEF-2 Kinase Inhibitor",NH125,"CaM Kinase III"}

> <classes>
{}

> <pubchem_cids>
{10436839}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 32  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -3.8976   -0.7554    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 N   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8912   -5.2578    0.0000 C   0  0
   -5.1887   -6.0105    0.0000 O   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 N   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 N   0  0
    2.5925    6.0081    0.0000 N   0  0
    2.5879    7.5089    0.0000 C   0  0
    3.8831    8.2656    0.0000 C   0  0
    3.8756    9.7655    0.0000 C   0  0
    2.5727   10.5090    0.0000 C   0  0
    1.2775    9.7524    0.0000 C   0  0
    1.2851    8.2524    0.0000 C   0  0
    2.5621   12.0098    0.0000 O   0  0
    1.2575   12.7517    0.0000 C   0  0
    1.2468   14.2517    0.0000 F   0  0
   -0.0364   11.9929    0.0000 F   0  0
   -0.0467   13.4927    0.0000 F   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
  3 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 15 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 23 26  1  0
 26 27  1  0
 27 28  1  0
 27 29  1  0
 27 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28794

> <plate>
Kinase v5-3

> <well>
K17

> <supplier_cmpd_name>
GNF-5

> <ctcr_id>
11899

> <supplier_cmpd_id>
S7526

> <smiles>
c1cc(cc(c1)C(=O)NCCO)c1cc(ncn1)Nc1ccc(cc1)OC(F)(F)F

> <pd_targets>
{ABL1,BCR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Atypical protein kinase group","Tyrosine protein kinase Abl family","Atypical protein kinase BCR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Abl family"}

> <pathway_reactome>
{Disease,"Infectious disease","Leishmania infection","Parasite infection","Leishmania phagocytosis","FCGR3A-mediated phagocytosis"}

> <broad_targets>
{ABL1,BCR}

> <broad_moa>
{"Bcr-Abl kinase inhibitor"}

> <synonyms>
{NF,GNF-5,GNF5,778277-15-9,778277159,"GNF 5",UNII-3ZUA56XMQQ,UNII3ZUA56XMQQ,3ZUA56XMQQ,CHEMBL1257423,MLS003230941,SCHEMBL924071,GTPL8065,AMMD00043,AOB6612,EX-A312,EXA312,HMS3653H13,HMS3744C21,BCP08970
,2436AH,ABP001115,BDBM50328152,MFCD16877246,s7526,ZINC64539753,AKOS022179178,AM85912,T1803}

> <pdid>
PD003245

> <targets>
{Bcr-Abl,SARS-CoV}

> <classes>
{Angiogenesis,Cytoskeletal Signaling,Anti-infection,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{44129660}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1968   -1.5004    0.0000 C   0  0
   -6.4971   -0.7525    0.0000 C   0  0
   -7.7950   -1.5046    0.0000 C   0  0
   -9.0952   -0.7567    0.0000 O   0  0
   -7.7926   -3.0046    0.0000 C   0  0
   -9.0904   -3.7567    0.0000 O   0  0
   -6.4923   -3.7525    0.0000 C   0  0
   -6.4900   -5.2525    0.0000 O   0  0
   -5.1945   -3.0005    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  1  0
 12  6  1  0
 12 13  2  0
 13  2  1  0
 10 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  1  0
 20 22  2  0
 22 14  1  0
  9 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28795

> <plate>
Kinase v5-3

> <well>
N06

> <supplier_cmpd_name>
Myricetin

> <ctcr_id>
5209

> <supplier_cmpd_id>
S2326

> <smiles>
Oc1cc(O)c2C(=O)C(=C(Oc2c1)c3cc(O)c(O)c(O)c3)O

> <pd_targets>
{IP6K2,IPMK,REP,POL,PIM1,MYLK,ACHE,KMT2A,MEN1,HSD17B10,THPO,KDM4E,APEX1,TDP1,MAPT,ALOX15,CYP2C9,ALPI,APOBEC3A,HSD17B3,DXR,ALPG,GLO1,SYK,BACE1,CSNK2A1,CSNK2A2,CSNK2B,CASP6,DAPK1,TOP2A,CDK5,PYK,RECQL,AL
DH1A1,DPP4,LEF,BLM,USP2,CYP1A1,AKR1B1,CYP19A1,FABI,INSR,NA,ALD,HPGD,IMPA1,APOBEC3G,FABZ,PIK3CG,AURKB,ELAVL3,E6,FLT3,APP,CBS,BRAF,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCQ,PRKCZ,CSNK2A3,AMY1A,HIF1A,PMP
22,CYP3A4,ALPL,CYP1A2,AKR1C21,CYP1B1,CD38,CYP2C19,FFP,CYP2D6,HTT,ABCC2,FABG,XDH,ABCC1,STK33,MAPK10,MAPK14,V-FPS,BCHE,ALOX12,L3MBTL1,AMPC,PSIP1,PRSS1,TGR,POLB,HSP90AB1,SLC2A2,MTOR,GPR35,IDE,DHODH,PSMB5
,SLC2A4,CASP7,NS3}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Unclassified protein","Other cytosolic protein","Membrane receptor","Transcription factor",Transporter,Transferase,Hydrolase,Kinase,Reader,Oxidoreductase,Eraser,Proteas
e,"Cytochrome P450",Phosphatase,Lyase,Isomerase,"Primary active transporter","Electrochemical transporter","Family A G protein-coupled receptor","Protein Kinase",Bromodomain,"Lysine demethylase","Cyst
eine protease","Cytochrome P450 family 2","Aspartic protease","Serine protease","Metallo protease","Cytochrome P450 family 1","Cytochrome P450 family 19","Cytochrome P450 family 3","ATP-binding casset
te","Methyl-lysine/arginine binding protein","SLC superfamily of solute carriers","Small molecule receptor (family A GPCR)","Threonine protease","CAMK protein kinase group","Jumonji domain-containing"
,"Cysteine protease CA clan","Cytochrome P450 family 2C","TK protein kinase group","Aspartic protease AA clan","Other protein kinase group","Cysteine protease CD clan","CMGC protein kinase group","Ser
ine protease SC clan","Metallo protease MAE clan","Cytochrome P450 family 1A","Cytochrome P450 family 19A","TKL protein kinase group","AGC protein kinase group","Cytochrome P450 family 3A","Cytochrome
 P450 family 1B","Cytochrome P450 family 2D","ABCC subfamily","MBT domain","Serine protease PA clan","SLC02 family of hexose and sugar alcohol transporters","Atypical protein kinase group","Carboxylic
 acid receptor","Threonine protease PBT clan","CAMK protein kinase PIM family","CAMK protein kinase MLCK family","Cysteine protease C1A family","Cytochrome P450 2C9","Tyrosine protein kinase Syk famil
y","Aspartic protease A1A subfamily","Other protein kinase CK2 family","Cysteine protease C14 family","CAMK protein kinase DAPK family","CMGC protein kinase CDK family","Serine protease S9B subfamily"
,"Metallo protease M34 family","Cysteine protease C19 family","Cytochrome P450 1A1","Cytochrome P450 19A1","Tyrosine protein kinase InsR family","Other protein kinase AUR family","Tyrosine protein kin
ase PDGFR family","TKL protein kinase RAF family","AGC protein kinase PKC family","Cytochrome P450 3A4","Cytochrome P450 1B1","Cytochrome P450 2C19","Cytochrome P450 2D6","CAMK protein kinase unique f
amily","CMGC protein kinase MAPK family","Tyrosine protein kinase Fer family","Serine protease S1A subfamily","Atypical protein kinase PIKK family","Kynurenic acid receptor","Threonine protease T1A su
bfamily","CMGC protein kinase CDK5 subfamily","AGC protein kinase PKC alpha subfamily","CMGC protein kinase JNK subfamily","CMGC protein kinase p38 subfamily","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{"Other protein targets",Enzymes,Receptors,Transporters,"Anti-infective targets","Kinases (EC 2.7.x.x)","Acetylcholine turnover","Chromatin modifying enzymes","Eicosanoid turnover","Cytochrome P450","
Catalytic receptors","Peptidases and proteinases","DNA topoisomerases","1.-.-.- Oxidoreductases","Inositol phosphate turnover","Hydrogen sulphide synthesis","Abscisic acid receptor complex","ATP-bindi
ng cassette transporter family","Heat shock proteins","SLC superfamily of solute carriers","G protein-coupled receptors","Viral protein targets","CAMK: Calcium/calmodulin-dependent protein kinases","1
.14.11.- Histone demethylases",Lipoxygenases,"CYP2 family: drug metabolising subset","Receptor kinases","AA: Aspartic (A) Peptidases","CD: Cysteine (C) Peptidases","CMGC: Containing CDK",MAPK,GSK3,"CL
K families","SC: Serine (S) Peptidases","CA: Cysteine (C) Peptidases","CYP1 family",CYP11,CYP17,CYP19,"CYP20 and CYP21 families","Prostaglandin synthases","Inositol monophosphatase","Lipid modifying k
inases","CYP3 family","ABCC subfamily","2.1.1.43 Histone methyltransferases (HMTs)","PA: Serine (S) Peptidases","SLC2 family of hexose and sugar alcohol transporters",Atypical,"Orphan and other 7TM re
ceptors","ME: Metallo (M) Peptidases","PB: Threonine (T) Peptidases","Coronavirus (CoV) proteins","PIM family","Myosin Light Chain Kinase (MLCK) family","TK: Tyrosine kinase","A1: Pepsin","C14: Caspas
e","Death-associated kinase (DAPK) family","Cyclin-dependent kinase (CDK) family","S9: Prolyl oligopeptidase","C19: Ubiquitin-specific protease",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"
,"Other protein kinases","TKL: Tyrosine kinase-like","CAMK-unique family","Mitogen-activated protein kinases (MAP kinases)","S1: Chymotrypsin","Class I transporters","Phosphatidyl inositol 3' kinase-r
elated kinases (PIKK) family","Class A Orphans","M16: Pitrilysin","T1: Proteasome","Non-receptor tyrosine kinases (nRTKs)","CDK5 subfamily","Receptor tyrosine kinases (RTKs)","Aurora kinase (Aur) fami
ly","RAF family","JNK subfamily","p38 subfamily","FRAP subfamily","Syk family","Type II RTKs: Insulin receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Immune System",Metabolism,Disease,"Signal Transduction",Hemostasis,"DNA Repair","Neuronal System","Metabolism of RNA","Metabolism of proteins","Gene expression (Transcription)","Programmed Cell Deat
h","Cell Cycle","Cellular responses to external stimuli","Developmental Biology","Transport of small molecules","Cytokine Signaling in Immune system","Inositol phosphate metabolism","Infectious diseas
e","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Rho GTPases","Metabolism of lipids","Metabolism of amino acids and derivatives","Platelet activation
","signaling and aggregation","Base Excision Repair","DNA Double-Strand Break Repair","Transmission across Chemical Synapses","Biological oxidations","mRNA Editing","Post-translational protein modific
ation","The citric acid (TCA) cycle and respiratory electron transport","Amyloid fiber formation","RNA Polymerase II Transcription",Apoptosis,Mitotic,"Peptide hormone metabolism","Intracellular signal
ing by second messengers","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Cellular responses to stress","Nervous system development","Metabolism of vitamins and cofactors","Disorders 
of transmembrane transporters","Metabolism of nucleotides","Signaling by GPCR","SLC-mediated transmembrane transport","Interferon Signaling","Synthesis of IPs in the nucleus","SARS-CoV Infections","FL
T3 signaling in disease","RHO GTPase Effectors","Phospholipid metabolism","Branched-chain amino acid catabolism","Platelet Aggregation (Plug Formation)","Resolution of Abasic Sites (AP sites)","Nonhom
ologous End-Joining (NHEJ)","Neurotransmitter receptors and postsynaptic signal transmission","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","mR
NA Editing: C to U Conversion","Fatty acid metabolism","Post-translational modification: synthesis of GPI-anchored proteins","Pyruvate metabolism and Citric Acid (TCA) cycle","Leishmania infection","G
eneric Transcription Pathway","Caspase activation via extrinsic apoptotic signalling pathway","Mitotic G1 phase and G1/S transition","Incretin synthesis",secretion,"and inactivation","Uptake and actio
ns of bacterial toxins","Homology Directed Repair","Metabolism of steroids","PIP3 activates AKT signaling","Synthesis of IP2",IP,"and Ins in the cytosol","HIV Infection","M Phase","Signaling by Insuli
n receptor","Toll-like Receptor Cascades","Selenoamino acid metabolism","Signaling by NTRKs","Cellular response to hypoxia","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Metabolism
 of water-soluble vitamins and cofactors","ABC transporter disorders","Nucleobase catabolism","Influenza Infection","Mitotic G2-G2/M phases","SLC transporter disorders","GPCR ligand binding",Deubiquit
ination,"Regulation of mitotic cell cycle","Cellular hexose transport","Intrinsic Pathway for Apoptosis","Interferon alpha/beta signaling","SARS-CoV-2 Infection","Signaling by FLT3 ITD and TKD mutants
","RHO GTPases activate PAKs","Glycerophospholipid biosynthesis","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","Activation of NMDA receptors and postsynaptic events","
Biosynthesis of DPA-derived SPMs","Cytochrome P450 - arranged by substrate type","Formation of the Editosome","Fatty acyl-CoA biosynthesis","Pyruvate metabolism","Leishmania parasite growth and surviv
al","Transcriptional Regulation by TP53","Caspase activation via Dependence Receptors in the absence of ligand","G0 and Early G1","Ethanol oxidation",Synthesis,"and inactivation of Glucagon-like Pepti
de-1 (GLP-1)","Uptake and function of anthrax toxins","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Metabolism of steroid hormones","Negative regulation of the PI3K/AK
T network","Biosynthesis of DHA-derived SPMs","Host Interactions of HIV factors","PI Metabolism","Mitotic Metaphase and Anaphase","Insulin receptor signalling cascade","Toll Like Receptor 5 (TLR5) Cas
cade","Metabolism of ingested SeMet",Sec,"MeSec into H2Se","Signaling by NTRK1 (TRKA)","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Nicotinate metabolism","Transcription
al Regulation by MECP2","Defective ABCC2 causes DJS","Purine catabolism","Arachidonic acid metabolism","Transcriptional regulation by RUNX1","HIV Life Cycle","Cobalamin (Cbl","vitamin B12) transport a
nd metabolism","Virus Assembly and Release","G2/M Transition","Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)","Class A/1 (Rhodopsin-like receptors)","Ub-specific processing proteases","APC/C-m
ediated degradation of cell cycle proteins","Apoptotic factor-mediated response","SARS-CoV-2 Genome Replication and Transcription","STAT5 activation downstream of FLT3 ITD mutants","Synthesis of PC","
PCNA-Dependent Long Patch Base Excision Repair","Post NMDA receptor activation events","Biosynthesis of DPAn-3 SPMs",Xenobiotics,"Synthesis of very long-chain fatty acyl-CoAs","Anti-inflammatory respo
nse favouring Leishmania parasite infection","TP53 Regulates Transcription of Cell Death Genes","Transcription of E2F targets under negative control by DREAM complex","Regulation of TP53 Activity","HD
R through Homologous Recombination (HRR)","Synthesis of PA","Pregnenolone biosynthesis","Endogenous sterols",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Biosynthesis of D-series resolvins","APOB
EC3G mediated resistance to HIV-1 infection","Synthesis of PIPs at the plasma membrane","Mitotic Anaphase","IRS-mediated signalling","MyD88 cascade initiated on plasma membrane","Signalling to ERKs","
Biosynthesis of maresins","Regulation of MECP2 expression and activity","Synthesis of Leukotrienes (LT) and Eoxins (EX)","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet f
unction","Early Phase of HIV Life Cycle","Assembly of Viral Components at the Budding Site","The role of GTSE1 in G2/M progression after G2 checkpoint","Activation of APC/C and APC/C:Cdc20 mediated de
gradation of mitotic proteins","Cytochrome c-mediated apoptotic response","Replication of the SARS-CoV-2 genome","Activation of AMPK downstream of NMDARs","Biosynthesis of DPAn-3-derived protectins an
d resolvins","CYP2E1 reactions","FCGR3A-mediated IL10 synthesis","TP53 Regulates Transcription of Caspase Activators and Caspases","Regulation of TP53 Activity through Phosphorylation","Homologous DNA
 Pairing and Strand Exchange","Regulation of TP53 Expression and Degradation","Separation of Sister Chromatids","PI3K Cascade","TAK1 activates NFkB by phosphorylation and activation of IKKs complex","
Prolonged ERK activation events","Biosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP kinase activation","Biosynthesis of DPAn-3-derived maresins
","Regulation of TP53 Activity through Methylation","Integration of provirus","Transport of HA trimer","NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus","APC/C:Cdc20 
mediated degradation of mitotic proteins","Activation of caspases through apoptosome-mediated cleavage","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradatio
n","ARMS-mediated activation","MAPK targets/ Nuclear events mediated by MAP kinases","2-LTR circle formation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cy
cle checkpoint","Activation of the AP-1 family of transcription factors","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{PIK3CG}

> <broad_moa>
{"androgen receptor agonist","cytochrome P450 inhibitor"}

> <synonyms>
{myricetin,529-44-2,529442,Cannabiscetin,Myricetol,"3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one","3,5,7Trihydroxy2(3,4,5trihydroxyphenyl)4Hchromen4one",Myricitin,"3,3',4',5,5',7-Hexah
ydroxyflavone","3,3',4',5,5',7Hexahydroxyflavone","3,5,7,3',4',5'-Hexahydroxyflavone","3,5,7,3',4',5'Hexahydroxyflavone","3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-one","3,3',4,4',5',7Hexahydro2p
henyl4Hchromen4one",UNII-76X,UNII76X,T0579,S2326,Myricetin}

> <pdid>
PD002690

> <targets>
{MEK,Others}

> <classes>
{Others}

> <pubchem_cids>
{5281672}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  1  0            999 V2000
    5.2311   -3.4009    0.0000 C   0  0
    3.8056   -3.8679    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.3786   -3.8595    0.0000 C   0  0
    1.8372   -5.2877    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -6.4971   -0.7566    0.0000 O   0  0
   -5.1945   -3.0046    0.0000 N   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -6.4915   -3.7597    0.0000 C   0  0  2  0  0  0
   -7.7922   -3.0110    0.0000 C   0  0
   -7.7951   -1.5110    0.0000 O   0  0
   -6.4870   -5.2605    0.0000 C   0  0
   -7.7822   -6.0172    0.0000 C   0  0
   -7.7746   -7.5172    0.0000 C   0  0
   -6.4718   -8.2606    0.0000 C   0  0
   -5.1766   -7.5040    0.0000 C   0  0
   -5.1842   -6.0041    0.0000 C   0  0
   -6.4643   -9.7606    0.0000 Cl  0  0
   -9.0699   -8.2737    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  3  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  0
 20 14  1  0
 18 21  1  0
 21 22  1  1
 22 23  1  0
 21 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 27 30  1  0
 26 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28796

> <plate>
Kinase v5-3

> <well>
M19

> <supplier_cmpd_name>
GDC-0994

> <ctcr_id>
12495

> <supplier_cmpd_id>
S7554

> <smiles>
Cn1c(ccn1)Nc1nccc(n1)c1cc(=O)n(cc1)[C@H](CO)c1cc(c(cc1)Cl)F

> <pd_targets>
{MAPK1,MAPK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{MAPK1,MAPK3}

> <broad_moa>
{"ERK1 and ERK2 phosphorylation inhibitor"}

> <synonyms>
{Ravoxertinib,GDC-0994,GDC0994,1453848-26-4,1453848264,UNII-R6AXV96CRH,UNIIR6AXV96CRH,R6AXV96CRH,RG-7842,RG7842,6QB,"Ravoxertinib (INN)","Ravoxertinib (USAN)","Ravoxertinib (USAN/INN)","Ravoxertinib (
USAN:INN)",GTPL9229,CHEMBL3544964,SCHEMBL15245531,BDBM120095,AOB87103,BCP096,T6511}

> <pdid>
PD021570

> <targets>
{ERK,ERK1,ERK2}

> <classes>
{MAPK}

> <pubchem_cids>
{71727581}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 42  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -3.8990   -0.7525    0.0000 C   0  0
   -4.2128    0.7135    0.0000 C   0  0
   -5.7049    0.8679    0.0000 C   0  0
   -6.3128   -0.5034    0.0000 N   0  0
   -1.2962   -3.7484    0.0000 F   0  0
    0.3114    2.9665    0.0000 C   0  0
    1.8032    3.1233    0.0000 C   0  0
    2.4133    1.7530    0.0000 S   0  0
    2.5550    4.4193    0.0000 C   0  0
    4.0558    4.4171    0.0000 N   0  0
    4.8104    5.7135    0.0000 C   0  0
    6.3104    5.7083    0.0000 C   0  0
    7.0559    4.4067    0.0000 N   0  0
    6.3014    3.1102    0.0000 C   0  0
    4.8014    3.1155    0.0000 C   0  0
    8.5567    4.3984    0.0000 C   0  0
    9.3008    3.0950    0.0000 C   0  0
   10.5494    2.4154    0.0000 C   0  0
    9.2451    1.6745    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 11  1  0
  8 16  1  0
  3 17  1  0
 17 18  2  0
 18 19  1  0
 19  2  1  0
 18 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 24 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 28  1  0
  1 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28797

> <plate>
Kinase v5-3

> <well>
M21

> <supplier_cmpd_name>
PI-3065

> <ctcr_id>
11407

> <supplier_cmpd_id>
S7623

> <smiles>
c1(c2c(nc(n1)c1c(ccc3c1cc[nH]3)F)cc(s2)CN1CCN(CC1)CC1CC1)N1CCOCC1

> <pd_targets>
{PIK3CA,PIK3R1,PIK3CB,PIK3CD}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Signaling by Receptor Tyrosine Kinases","Cytokine Signaling in Immune system","Signaling by Insulin receptor","Signaling by Interleukins","Insulin receptor sign
alling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","IRS-mediated signalling","Interleukin receptor SHC signaling","PI3K Cascade"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{PI-3065,PI3065,955977-50-1,955977501,"PI 3065",CHEMBL4450504,GTPL8242,SCHEMBL2468696,EX-A531,EXA531,AOB87791,BCP12801,BDBM50507818,MFCD28167771,s7623,AKOS025404833,ZINC144899724,CCG-269751,CCG269751,
LM-3414,LM3414,PI-3065|PI3065,PI3065|PI3065,NCGC00386429-03,NCGC0038642903,AC-30278,AC30278,AK174780,AS-55952,AS55952,DA-40130,DA40130,H,T2083}

> <pdid>
PD013000

> <targets>
{PI3K,DNA-PK,mTOR,p110¦Á,p110¦Â,p110¦Ä}

> <classes>
{"DNA Damage/DNA Repair","PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{24937012}

$$$$
UTKinase_V5
  SciTegic11012413002D

 65 71  0  0  1  0            999 V2000
    1.2889   -5.8027    0.0000 C   0  0  1  0  0  0
    2.2806   -4.6772    0.0000 C   0  0  1  0  0  0
    3.7511   -4.9733    0.0000 C   0  0  2  0  0  0
    4.2300   -6.3948    0.0000 C   0  0  1  0  0  0
    3.2383   -7.5202    0.0000 C   0  0  2  0  0  0
    1.7678   -7.2242    0.0000 O   0  0
    3.7204   -8.9416    0.0000 C   0  0
    2.7318  -10.0697    0.0000 O   0  0
    5.7005   -6.6908    0.0000 O   0  0
    4.4122   -4.2230    0.0000 O   0  0
    1.9614   -3.7296    0.0000 O   0  0
   -0.1818   -5.5036    0.0000 O   0  0
   -0.6590   -4.0805    0.0000 C   0  0  1  0  0  0
    0.8112   -4.3783    0.0000 C   0  0
   -2.1306   -3.7857    0.0000 C   0  0
   -3.1224   -4.9120    0.0000 C   0  0
   -4.5940   -4.6171    0.0000 C   0  0
   -5.5859   -5.7435    0.0000 C   0  0
   -7.0566   -5.4488    0.0000 C   0  0
   -5.2661   -6.6910    0.0000 C   0  0
    0.3326   -2.9571    0.0000 C   0  0  1  0  0  0
    1.8253   -3.1044    0.0000 C   0  0
    2.4266   -1.7302    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    1.2990    0.7500    0.0000 C   0  0  2  0  0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0  1  0  0  0
    1.2990    3.7500    0.0000 C   0  0  1  0  0  0
    1.2990    5.2500    0.0000 C   0  0
    0.0000    6.0000    0.0000 C   0  0  2  0  0  0
   -1.2991    5.2500    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0  2  0  0  0
    0.0000    1.5000    0.0000 C   0  0  1  0  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0  2  0  0  0
    0.0000   -1.5000    0.0000 C   0  0  2  0  0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2991    2.2500    0.0000 C   0  0
   -0.0001    7.5000    0.0000 O   0  0
    2.5800    4.4696    0.0000 C   0  0
    1.2638    6.7496    0.0000 C   0  0
    3.8994    3.7478    0.0000 O   0  0
    5.1980    2.9955    0.0000 C   0  0  1  0  0  0
    6.4997    3.7410    0.0000 C   0  0  1  0  0  0
    7.7962    2.9865    0.0000 C   0  0  2  0  0  0
    7.7910    1.4865    0.0000 C   0  0  1  0  0  0
    6.4894    0.7410    0.0000 C   0  0  2  0  0  0
    5.1929    1.4955    0.0000 O   0  0
    6.4873   -0.7598    0.0000 C   0  0
    7.7848   -1.5125    0.0000 O   0  0
    9.0874    0.7320    0.0000 O   0  0
    9.0978    3.7320    0.0000 O   0  0
    6.5019    5.2418    0.0000 O   0  0
    5.2037    5.9949    0.0000 C   0  0  1  0  0  0
    5.2036    7.4949    0.0000 C   0  0  1  0  0  0
    3.9046    8.2450    0.0000 C   0  0  2  0  0  0
    2.6056    7.4950    0.0000 C   0  0  1  0  0  0
    2.6055    5.9950    0.0000 C   0  0
    3.9045    5.2450    0.0000 O   0  0
    1.3065    8.2450    0.0000 O   0  0
    3.9047    9.7450    0.0000 O   0  0
    6.5027    8.2449    0.0000 O   0  0
    2.1651    0.2500    0.0000 C   0  0
    2.2090   -0.3353    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  5  7  1  1
  7  8  1  0
  4  9  1  6
  3 10  1  1
  2 11  1  6
  1 12  1  1
 12 13  1  0
 13 14  1  6
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  3
 18 19  1  0
 18 20  1  0
 13 21  1  0
 21 22  1  6
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  6
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 28  1  0
 33 34  1  0
 34 25  1  0
 34 35  1  6
 35 36  1  0
 37 36  1  1
 37 21  1  0
 37 24  1  0
 36 38  1  6
 33 39  1  6
 30 40  1  6
 29 41  1  0
 29 42  1  0
 27 43  1  1
 44 43  1  1
 44 45  1  0
 45 46  1  0
 46 47  1  0
 47 48  1  0
 48 49  1  0
 49 44  1  0
 48 50  1  1
 50 51  1  0
 47 52  1  6
 46 53  1  1
 45 54  1  6
 55 54  1  6
 55 56  1  0
 56 57  1  0
 57 58  1  0
 58 59  1  0
 59 60  1  0
 60 55  1  0
 58 61  1  1
 57 62  1  6
 56 63  1  1
 25 64  1  6
 24 65  1  1
M  END
> <name>
UTKinase_V5

> <id>
28798

> <plate>
Kinase v5-3

> <well>
M03

> <supplier_cmpd_name>
Notoginsenoside R1

> <ctcr_id>
11889

> <supplier_cmpd_id>
S3785

> <smiles>
[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O[C@@](C)(CCC=C(C)C)[C@H]1CC[C@]2([C@@]3(C[C@@H]([C@H]4C([C@H](CC[C@@]4([C@H]3C[C@H]([C@H]12)O)C)O)(C)C)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O[C@H]1
[C@@H]([C@H]([C@@H](CO1)O)O)O)C)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Notoginsenoside R1",80418-24-2,80418242,notoginsenoside-R1,notoginsenosideR1,"Sanchinoside R1",UNII-Z62692362Z,UNIIZ62692362Z,CHEBI:77149,MFCD00210535,Z62692362Z,"O-Acetylseudolaric acid C","OAcetyl
seudolaric acid C",CHEMBL507115,C47H80O18,"(20S)-ginsenoside R1","(20S)ginsenoside R1","HSDB 8111",HY-N0615,HYN0615,s3785,AKOS02531147,T2961}

> <pdid>
PD056363

> <targets>
{Others,ERK1,ERK2}

> <classes>
{MAPK}

> <pubchem_cids>
{441934}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  1  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
   -1.3039    3.7494    0.0000 S   0  0
   -2.6017    2.9971    0.0000 O   0  0
   -1.3015    2.2494    0.0000 O   0  0
   -1.3070    5.2502    0.0000 C   0  0
   -2.6076    5.9975    0.0000 C   0  0
   -2.6107    7.4975    0.0000 C   0  0
   -1.3132    8.2502    0.0000 C   0  0
   -0.0126    7.5029    0.0000 C   0  0
   -0.0095    6.0029    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8933   -3.7570    0.0000 C   0  0
   -3.8934   -5.2570    0.0000 C   0  0
   -5.1924   -6.0071    0.0000 C   0  0
   -6.4914   -5.2571    0.0000 C   0  0
   -7.7927   -6.0049    0.0000 C   0  0
   -9.0914   -5.2527    0.0000 N   0  0
   -9.2242   -3.7713    0.0000 C   0  0
  -10.6903   -3.4544    0.0000 C   0  0
  -11.4448   -4.7508    0.0000 C   0  0
  -10.4449   -5.8690    0.0000 C   0  0  2  0  0  0
  -10.7533   -7.3351    0.0000 C   0  0
  -12.1786   -7.8027    0.0000 O   0  0
   -6.4915   -3.7571    0.0000 C   0  0
   -5.1925   -3.0071    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  2  0
  6  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
  4 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 24  1  0
 28 29  1  1
 29 30  1  0
 22 31  1  0
 31 32  2  0
 32 19  1  0
 16 33  2  0
 33  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28801

> <plate>
Kinase v5-3

> <well>
M09

> <supplier_cmpd_name>
PF-543

> <ctcr_id>
7598

> <supplier_cmpd_id>
Se S7177

> <smiles>
Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc3ccc(CN4CCC[C@@H]4CO)cc3)c1

> <pd_targets>
{SPHK1,SPHK2}

> <pathway_gtopdb>
{Enzyme}

> <pathway_chembl>
{Enzymes,"Sphingosine 1-phosphate turnover","Sphingosine kinase"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,"Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","Signaling by VEGF","Sphingolipid metabolism","VEGFA-VEGFR2 Pathway","Sphingolipid de novo biosynthesi
s","VEGFR2 mediated cell proliferation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{PF-543,PF543,1415562-82-1,1415562821,"PF 543",CHEMBL3134157,C27H31NO4S,GTPL6623,SCHEMBL17786131,DTXSID90735359,CHEBI:131144,BCP07072,BDBM50041978,ZINC94568743,CCG-269412,CCG269412,CS-0869,CS0869,SB19
553,"compound 22a (PMID: 22397330)",NCGC00346972-04,NCGC0034697204,HY-15425,HY15425,S7177,SW218168-2,SW2181682}

> <pdid>
PD003318

> <targets>
{"S1P Receptor"}

> <classes>
{"GPCR & G Protein"}

> <pubchem_cids>
{66577038}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
   -1.3109   -5.2364    0.0000 C   0  0
   -0.0156   -5.9927    0.0000 S   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -3.9015    3.7525    0.0000 Cl  0  0
   -6.4995    3.7483    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -6.4948    0.7483    0.0000 C   0  0
   -6.4924   -0.7517    0.0000 Cl  0  0
    1.2935   -3.7495    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  3
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 17 19  1  0
 19 12  1  0
 19 20  2  0
 20  9  1  0
 14 21  1  0
 21 22  2  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 21  1  0
 27 28  1  0
  7 29  2  0
 29  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28802

> <plate>
Kinase v5-3

> <well>
M11

> <supplier_cmpd_name>
PD173955

> <ctcr_id>
526

> <supplier_cmpd_id>
S7269

> <smiles>
CSc1cccc(Nc2ncc3C=C(C(=O)N(C)c3n2)c4c(Cl)cccc4Cl)c1

> <pd_targets>
{FGFR1,PDGFRA,PDGFRB,ABL1,TEC,FLT3,EPHB3,AURKC,ACVR1,ACVR2A,DDR1,TNK1,CSF1R,EGFR,EPHA1,TIE1,NEK1,CDC42BPG,TAOK1,FGFR4,MAP3K4,BRAF,RET,TESK1,TAOK3,STK26,MAP3K19,NEK11,PKMYT1,NEK5,WEE2,FGFR3,STK32A,MARK
3,SMO,TYRO3,STK25,FLT1,MAP3K11,LCK,MARK2,MAP3K9,NIM1K,PTK2B,DDR2,KIT,TNK2,ACVR2B,BLK,BMX,HCK,LYN,PTK6,MAP3K2,LIMK1,EPHB1,JAK2,MAPK14,SRC,YES1,NLK,MAP2K3,RIPK1,STK35,MAP4K1,MAP2K1,MAP2K6,RIPK2,MAP2K4,C
DPK1,STK24,PLK3,EPHA2,TGFBR1,SIK1,RAF1,SYK,CDC42BPB,STK3,SIK2,MAP2K5,MINK1,ABL2,LIMK2,TAOK2,EPHB2,MYLK2,BRSK1,LRRK2,JAK1,BTK,MET,EIF2AK4,MAPK4,MAP3K3,EPHB4,CSK,FER,COQ8A,FGFR2,PIP4K2C,ACVRL1,TEK,STK4,
NEK2,EPHA3,ACVR1B,EPHA5,MYLK3,SBK3,JAK3,ERBB3,FES,TXK,CDC42BPA,MAP4K3,SLK,TNNI3K,MAP2K2,SRMS,BCR,MAPK8,TYK2,MAP4K2,ERBB4,TGFBR2,BRSK2,MST1R,FGR,STK36,STK32B,COQ8B,EPHA6,MAPK11,BMPR1A,EPHB6,GAK,STK10,M
AP3K20,FYN,FLT4,KDR,MAP3K10,MAPK6,EPHA4,MAP4K4,BMPR1B,FRK,EPHA8,WEE1,NTRK3,TNIK,MAP4K5,SIK3,ALK,NPM1}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Unclassified protein",Kinase,"Frizzled family G protein-coupled receptor",Transferase,"Protein Kinase","Smoothened receptor (frizzled family GPCR)","TK protein kinase grou
p","Other protein kinase group","TKL protein kinase group","AGC protein kinase group","STE protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Atypical protein kinase group"
,"Tyrosine protein kinase FGFR family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Eph family","Other prot
ein kinase AUR family","TKL protein kinase STKR family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Ack family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Tie fam
ily","Other protein kinase NEK family","AGC protein kinase DMPK family","STE protein kinase STE20 family","STE protein kinase STE11 family","TKL protein kinase RAF family","Tyrosine protein kinase Ret
 family","TKL protein kinase LISK family","Other protein kinase WEE family","AGC protein kinase YANK family","CAMK protein kinase CAMK1 family","Tyrosine protein kinase Axl family","Tyrosine protein k
inase VEGFR family","TKL protein kinase MLK family","Tyrosine protein kinase Src family","Tyrosine protein kinase Fak family","Tyrosine protein kinase JakA family","CMGC protein kinase MAPK family","S
TE protein kinase STE7 family","TKL protein kinase RIPK family","Other protein kinase NKF4 family","Other protein kinase PLK family","Tyrosine protein kinase Syk family","CAMK protein kinase MLCK fami
ly","TKL protein kinase LRRK family","Tyrosine protein kinase Met family","Other protein kinase PEK family","Tyrosine protein kinase Csk family","Tyrosine protein kinase Fer family","Other protein kin
ase NKF1 family","Atypical protein kinase BCR family","Other protein kinase ULK family","Atypical protein kinase ABC1 family","Other protein kinase NAK family","Tyrosine protein kinase Trk family","TK
L protein kinase STKR1","TKL protein kinase STKR Type 2 subfamily","AGC protein kinase GEK subfamily","STE protein kinase TAO subfamily","TKL protein kinase TESK subfamily","STE protein kinase YSK sub
family","Other protein kinase Nek11","Other protein kinase WEE1","CAMK protein kinase MARK subfamily","TKL protein kinase MLK subfamily","CAMK protein kinase NIM1 subfamily","STE protein kinase MEKK2"
,"TKL protein kinase LIMK subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase nmo subfamily","STE protein kinase KHS subfamily","TKL protein kinase STKR Type 1 subfamily","CAMK protein
 kinase QIK subfamily","STE protein kinase MST subfamily","STE protein kinase MSN subfamily","CAMK protein kinase BRSK subfamily","Other protein kinase GCN2 subfamily","CMGC protein kinase ERK3","STE 
protein kinase SLK subfamily","TKL protein kinase HH498 subfamily","Tyrosine protein kinase Srm","CMGC protein kinase JNK subfamily","Atypical protein kinase ABC1-A subfamily","Tyrosine protein kinase
 SrcA"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","G protein-coupled receptors","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","STE: Homologs of yeast Sterile 7","Sterile 11
","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Class Frizzled GPCRs","CMGC: Containing CDK",MAPK,GSK3,"CLK families",Atypical,"Lipid modifying kinases","TK: Tyrosine kina
se","Other protein kinases","TKL: Tyrosine kinase-like","DMPK family","STE20 family","STE11 family","YANK family","CAMK-like (CAMKL) family","Mitogen-activated protein kinases (MAP kinases)","STE7 fam
ily","Myosin Light Chain Kinase (MLCK) family","ABC1 family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinase
s (nRTKs)","Aurora kinase (Aur) family","Receptor serine/threonine kinase (RSTK) family","NIMA (never in mitosis gene a)- related kinase (NEK) family","GEK subfamily","TAO subfamily","RAF family","LIM
 domain kinase (LISK) family","YSK subfamily","STE20 subfamily","WEE family","MARK subfamily","Mixed Lineage Kinase (MLK) family","NIM1 subfamily","p38 subfamily","nmo subfamily","Receptor interacting
 protein kinase (RIPK) family","NKF4 family","KHS subfamily","Polo-like kinase (PLK) family","QIK subfamily","MST subfamily","MSN subfamily","BRSK subfamily","Leucine-rich repeat kinase (LRRK) family"
,"PEK family","ERK subfamily","ABC1-B subfamily","NKF1 family","SLK subfamily","JNK subfamily","Unc-51-like kinase (ULK) family","Numb-associated kinase (NAK) family","Type V RTKs: FGF (fibroblast gro
wth factor) receptor family","Abl family","Tec family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIII RTKs: Ephrin receptor family","Type I receptor serine/threonine kinases","Type 
II receptor serine/threonine kinases","Type XVI RTKs: DDR (collagen receptor) family","Ack family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XII RTKs: TIE family of angiopoie
tin receptors","Type XIV RTKs: RET","TESK subfamily","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","MLK subfa
mily","Src family","Fak family","LIMK subfamily","Janus kinase (JakA) family","Syk family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","GCN2 subfamily","Csk family","Fer family","HH4
98 subfamily","Type VII RTKs: Neurotrophin receptor/Trk family"}

> <pathway_reactome>
{Disease,"Immune System","Signal Transduction","Developmental Biology","Extracellular matrix organization","Gene expression (Transcription)","Cell Cycle","Cell-Cell communication","Programmed Cell Dea
th","Organelle biogenesis and maintenance",Metabolism,"Circadian Clock","Cellular responses to external stimuli","Neuronal System","Vesicle-mediated transport","Diseases of signal transduction by grow
th factor receptors and second messengers","Infectious disease","Cytokine Signaling in Immune system","Signaling by Receptor Tyrosine Kinases","Nervous system development","Signaling by NODAL","Non-in
tegrin membrane-ECM interactions","RNA Polymerase II Transcription","Signaling by GPCR",Mitotic,"Intracellular signaling by second messengers","Cell junction organization",Apoptosis,"Cilium Assembly",
"Metabolism of lipids","Innate Immune System","Signaling by WNT","MAPK family signaling cascades","Signaling by Hippo","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases","Sign
aling by TGFB family members","Transmission across Chemical Synapses","Membrane Trafficking","Cell Cycle Checkpoints","Signaling by FGFR in disease","Leishmania infection","Signaling by Interleukins",
"Signaling by Insulin receptor","Axon guidance","Regulation of signaling by NODAL","Generic Transcription Pathway","GPCR downstream signalling","M Phase","Signaling by FGFR","PIP3 activates AKT signal
ing","Signaling by NTRKs","Cell-extracellular matrix interactions","Apoptotic execution phase","Mitotic G2-G2/M phases","Oncogenic MAPK signaling","Cargo trafficking to the periciliary membrane","Sign
aling by VEGF","Signaling by PDGFR in disease","HIV Infection","Signaling by KIT in disease","Phospholipid metabolism","Mitotic G1 phase and G1/S transition","Toll-like Receptor Cascades","Beta-cateni
n independent WNT signaling","Signaling by TGF-beta Receptor Complex in Cancer","MAPK1/MAPK3 signaling","Cellular Senescence","Signaling by PTK6","Interferon Signaling","Response of EIF2AK4 (GCN2) to 
amino acid deficiency","MAPK6/MAPK4 signaling","Signaling by SCF-KIT","Signaling by BMP","Regulation of mitotic cell cycle","Fc epsilon receptor (FCERI) signaling","Neurotransmitter receptors and post
synaptic signal transmission","Signaling by MST1","trans-Golgi Network Vesicle Budding","Neutrophil degranulation","G2/M Checkpoints","Signaling by FGFR1 in disease","Parasite infection",Interleukin-3
,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","EPH-Ephrin signaling","Transcriptional Regulation by VENTX","G alpha (q) signalling events","Mitotic Metaphase and Anaphase
","Signaling by FGFR4","Negative regulation of the PI3K/AKT network","Signaling by NTRK1 (TRKA)","RET signaling","Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","A
poptotic cleavage of cellular proteins","G2/M Transition","Signaling by FGFR3 in disease","Signaling by RAS mutants","BBSome-mediated cargo-targeting to cilium","VEGF ligand-receptor interactions","Dr
ug resistance of PDGFR mutants","Host Interactions of HIV factors","Interleukin-2 family signaling","Drug resistance of KIT mutants","Transcriptional regulation by RUNX1","PI Metabolism","Leishmania p
arasite growth and survival","G1 Phase","Semaphorin interactions","Toll Like Receptor 5 (TLR5) Cascade","Ca2+ pathway","Toll Like Receptor 4 (TLR4) Cascade","Transcriptional Regulation by TP53","Loss 
of Function of SMAD2/3 in Cancer","RAF/MAP kinase cascade","Oxidative Stress Induced Senescence","Signaling by ROBO receptors","PTK6 promotes HIF1A stabilization","Antiviral mechanism by IFN-stimulate
d genes","Interleukin-1 family signaling","Signaling by FGFR2 in disease","APC/C-mediated degradation of cell cycle proteins","FCERI mediated Ca+2 mobilization","PTK6 Down-Regulation","Interferon alph
a/beta signaling","Activation of NMDA receptors and postsynaptic events","Golgi Associated Vesicle Biogenesis","VEGFA-VEGFR2 Pathway","PTEN Regulation","G2/M DNA damage checkpoint","Signaling by NTRK3
 (TRKC)","FGFR1 mutant receptor activation","Leishmania phagocytosis","IRS-mediated signalling","EPHB-mediated forward signaling","Gastrin-CREB signalling pathway via PKC and MAPK","EPHA-mediated grow
th cone collapse","Mitotic Anaphase","Downstream signaling of activated FGFR4",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Signalling to ERKs","Cyclin A/B1/B2 associated events during G2/M trans
ition","Signaling by FGFR3 point mutants in cancer","Signaling downstream of RAS mutants","VEGF binds to VEGFR leading to receptor dimerization","Imatinib-resistant PDGFR mutants","The role of Nef in 
HIV-1 replication and disease pathogenesis","Interleukin-2 signaling","Dasatinib-resistant KIT mutants","RUNX1 regulates transcription of genes involved in BCR signaling","Synthesis of PIPs at the pla
sma membrane","Anti-inflammatory response favouring Leishmania parasite infection","Cyclin D associated events in G1","Sema4D in semaphorin signaling","MyD88 cascade initiated on plasma membrane","MyD
88-independent TLR4 cascade","Regulation of TP53 Activity","SMAD2/3 Phosphorylation Motif Mutants in Cancer","Negative regulation of MAPK pathway","Signalling to ERK5","Role of ABL in ROBO-SLIT signal
ing","ISG15 antiviral mechanism","Interleukin-1 signaling","FGFR2 mutant receptor activation","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Interleukin-15 signaling",
"CRMPs in Sema3A signaling","Regulation of IFNA signaling","Post NMDA receptor activation events","VEGFR2 mediated cell proliferation","Regulation of PTEN stability and activity","Chk1/Chk2(Cds1) medi
ated inactivation of Cyclin B:Cdk1 complex","Activated NTRK3 signals through PI3K","Signaling by activated point mutants of FGFR1","FCGR3A-mediated phagocytosis","PI3K Cascade","EGFR Transactivation b
y Gastrin","Separation of Sister Chromatids","FRS-mediated FGFR4 signaling","Prolonged ERK activation events","FGFR3 mutant receptor activation","Nef-mediates down modulation of cell surface receptors
 by recruiting them to clathrin adapters","Nef and signal transduction","FCGR3A-mediated IL10 synthesis","Sema4D induced cell migration and growth-cone collapse","MAP kinase activation","Signalling to
 RAS","TRIF(TICAM1)-mediated TLR4 signaling","Regulation of TP53 Activity through Acetylation","Regulation of TP53 Activity through Phosphorylation","Negative feedback regulation of MAPK pathway","Sem
a4D mediated inhibition of cell attachment and migration","Activated point mutants of FGFR2","APC/C:Cdc20 mediated degradation of mitotic proteins","Long-term potentiation","ARMS-mediated activation",
"Signaling by activated point mutants of FGFR3","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","activated TAK1 mediates p38 MAPK activation"
,"IKK complex recruitment mediated by RIP1","Frs2-mediated activation","PI5P Regulates TP53 Acetylation","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1","APC:Cdc
20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Activation of the AP-1 family of transcription factors","APC-Cdc20 mediated degradation of Nek2A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{BDBM6568,GTPL5699,DTXSID90332241,SYN1061,BCPP000124,BCP02294,EX-A2125,EXA2125,ZINC2047743,AKOS026750643,BCP9001059,PD173955,260415-63-2,260415632,PD-173955,"Pd 173955",CHEMBL386051,PD-0173955,PD01739
55,CHEBI:49791,C21H16cl2N4OS,PubChem22476,PD-17395,PD17395,SCHEMBL256712,CS-3550,CS3550,DB025,T3063,SY-PD173955,S7269}

> <pdid>
PD007860

> <targets>
{BCR-ABL,c-Src,Bcr-Abl}

> <classes>
{}

> <pubchem_cids>
{447077}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 17  0  0  0  0            999 V2000
    3.8983   -0.7512    0.0000 C   0  0
    2.5988   -1.5004    0.0000 C   0  0
    2.5983   -3.0004    0.0000 C   0  0
    3.8975   -2.2510    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   -2.5998    3.0012    0.0000 C   0  0
   -3.8995    3.7516    0.0000 C   0  0
   -3.9005    5.2525    0.0000 C   0  0
   -3.9014    6.7525    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  8 11  1  0
 11 12  2  0
 11 13  2  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  3  0
M  END
> <name>
UTKinase_V5

> <id>
28803

> <plate>
Kinase v5-3

> <well>
M13

> <supplier_cmpd_name>
Bay 11-7085

> <ctcr_id>
7616

> <supplier_cmpd_id>
S7352

> <smiles>
CC(C)(C)c1ccc(cc1)[S](=O)(=O)\C=C\C#N

> <pd_targets>
{REP,LMNA,ALDH1A1,MAPT,PMP22,HPGD,GMNN,BLM,NPSR1,CCR2,DRD3}

> <pathway_gtopdb>
{Enzyme,"Other nuclear protein","Other cytosolic protein","Unclassified protein","Membrane receptor",Transferase,Oxidoreductase,"Family A G protein-coupled receptor","Peptide receptor (family A GPCR)"
,"Small molecule receptor (family A GPCR)","Short peptide receptor (family A GPCR)","Monoamine receptor","Chemokine receptor","Neuropeptide receptor","Dopamine receptor","CC chemokine receptor"}

> <pathway_chembl>
{"Other protein targets",Enzymes,Receptors,"Anti-infective targets","Eicosanoid turnover","G protein-coupled receptors","Viral protein targets","Prostaglandin synthases","Neuropeptide S receptor","Dop
amine receptors","Chemokine receptors","Coronavirus (CoV) proteins"}

> <pathway_reactome>
{Disease,"Cell Cycle",Metabolism,"Neuronal System","Developmental Biology","DNA Repair","Signal Transduction","Infectious disease",Mitotic,"Biological oxidations","Transmission across Chemical Synapse
s","Nervous system development","Metabolism of lipids","DNA Double-Strand Break Repair","Signaling by GPCR","SARS-CoV Infections","M Phase","Phase I - Functionalization of compounds","Neurotransmitter
 receptors and postsynaptic signal transmission","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Biosynthesis of specialized proresolving mediators (SPMs)","Mitotic G1 phase and G1/S
 transition","Homology Directed Repair","Leishmania infection","GPCR ligand binding","SARS-CoV-2 Infection","Mitotic Metaphase and Anaphase","Ethanol oxidation","Activation of NMDA receptors and posts
ynaptic events","Biosynthesis of DHA-derived SPMs","G1/S Transition","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Leishmania parasite growth and survival","Class A/1 
(Rhodopsin-like receptors)","SARS-CoV-2 Genome Replication and Transcription","Mitotic Anaphase","Post NMDA receptor activation events","Biosynthesis of D-series resolvins","Activation of the pre-repl
icative complex","HDR through Homologous Recombination (HRR)","Anti-inflammatory response favouring Leishmania parasite infection","Peptide ligand-binding receptors","Amine ligand-binding receptors","
Replication of the SARS-CoV-2 genome","Nuclear Envelope (NE) Reassembly","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","ADORA2B mediated anti-inflammatory cyto
kines production","Chemokine receptors bind chemokines","Dopamine receptors","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{NFKBIA}

> <broad_moa>
{"NFkB pathway inhibitor"}

> <synonyms>
{"AY 11708","bay 11-7085","bay 117085",196309-76-9,196309769,(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile,(E)3(4tertbutylphenylsulfonyl)acrylonitrile,(E)-3-((4-(tert-Butyl)phenyl)sulfonyl)acrylonit
rile,(E)3((4(tertButyl)phenyl)sulfonyl)acrylonitrile,"BAY 11-7083","BAY 117083",(E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile,(E)3(4tertbutylphenyl)sulfonylprop2enenitrile,BAY-11-7085,BAY117085,
(E)-3-(4-t-Butylphenylsulfonyl)-2-pro,(E)3(4tButylphenylsulfonyl)2pro,T1934,nan,"Bay 11-7085"}

> <pdid>
PD015391

> <targets>
{I?B/IKK,"NF-kappa B"}

> <classes>
{}

> <pubchem_cids>
{5353432}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 N   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 N   0  0
   -2.5925   -6.0081    0.0000 N   0  0
   -2.5879   -7.5089    0.0000 C   0  0
   -3.8832   -8.2655    0.0000 C   0  0
   -3.8756   -9.7655    0.0000 C   0  0
   -2.5728  -10.5090    0.0000 C   0  0
   -1.2775   -9.7524    0.0000 C   0  0
   -1.2851   -8.2524    0.0000 C   0  0
    0.0275  -10.4936    0.0000 C   0  0
    1.3224   -9.7348    0.0000 S   0  0
    2.6267  -10.4755    0.0000 O   0  0
    1.3122   -8.2348    0.0000 O   0  0
    2.6162   -8.9758    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 11 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 20 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  2  0
 23 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28804

> <plate>
Kinase v5-3

> <well>
M15

> <supplier_cmpd_name>
LDC000067

> <ctcr_id>
11627

> <supplier_cmpd_id>
S7461

> <smiles>
COc1ccccc1c1cc(ncn1)Nc1cccc(c1)CS(=O)(=O)N

> <pd_targets>
{CDK5,CDK5R1,CCNT1,CDK9,CCND1,CDK4,CCNB1,CDK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{LDC000067,1073485-20-7,1073485207,(3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methanesulfonamide,(3((6(2methoxyphenyl)pyrimidin4yl)amino)phenyl)methanesulfonamide,LDC067,CHEMBL3263773,(3-(6-(
2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide,(3(6(2Methoxyphenyl)pyrimidin4ylamino)phenyl)methanesulfonamide,3-((6-(2-Methoxyphenyl)-4-pyrimidinyl)amino)benzenemethanesul,3((6(2Methox
yphenyl)4pyrimidinyl)amino)benzenemethanesul,T6563}

> <pdid>
PD010305

> <targets>
{CDK,CDK1,CDK2,CDK4,CDK6,CDK9}

> <classes>
{"Cell Cycle/Checkpoint"}

> <pubchem_cids>
{25104564}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 33  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -0.0136    6.0070    0.0000 O   0  0
   -0.0210    7.5070    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -3.9073    5.2404    0.0000 C   0  0
   -5.2081    5.9890    0.0000 C   0  0
   -6.5058    5.2368    0.0000 O   0  0
   -5.2112    7.4898    0.0000 N   0  0
   -6.5102    8.2399    0.0000 C   0  0
   -6.5102    9.7399    0.0000 C   0  0
   -5.2111   10.4899    0.0000 O   0  0
   -3.9121    9.7399    0.0000 C   0  0
   -3.9121    8.2399    0.0000 C   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -5.1985    2.9859    0.0000 F   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2986   -3.7517    0.0000 F   0  0
    1.2993   -3.7504    0.0000 F   0  0
    0.0007   -4.5008    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
 13 22  1  0
 22 23  1  0
 22 24  2  0
 24  8  1  0
  6 25  2  0
 25 26  1  0
 26 27  2  0
 27  4  1  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 28 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28805

> <plate>
Kinase v5-3

> <well>
M17

> <supplier_cmpd_name>
GNE-7915

> <ctcr_id>
11452

> <supplier_cmpd_id>
S7528

> <smiles>
CCNc1nc(Nc2c(OC)cc(C(=O)N3CCOCC3)c(F)c2)ncc1C(F)(F)F

> <pd_targets>
{TTK,LRRK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","TKL protein kinase group","Other protein kinase TTK family","TKL protein kinase LRRK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","TKL: Tyrosine kinase-like","TTK family","Leucine-rich repeat kinase (LRRK) family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Non-Receptor Tyrosine Kinases","Signaling by PTK6","PTK6 promotes HIF1A stabilization"}

> <broad_targets>
{}

> <broad_moa>
{"leucine rich repeat kinase inhibitor"}

> <synonyms>
{GNE-7915,GNE7915,1351761-44-8,1351761448,"GNE 7915",CHEMBL2178134,GTPL8073,SCHEMBL7456100,HMS3653J13,HMS3674E09,AOB87767,BCP09873,EX-A1001,EXA1001,BDBM50398668,MFCD25977005,s7528,ZINC95578650,AKOS026
750276,CCG-269162,CCG269162,SB19411,NCGC00386346-05,NCGC0038634605,AK474042,AS-17060,AS17060,DA-3360,DA3360,T1945}

> <pdid>
PD003214

> <targets>
{LRRK2}

> <classes>
{Autophagy}

> <pubchem_cids>
{58539171}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 26  0  0  0  0            999 V2000
    6.4890   -5.2627    0.0000 C   0  0
    5.1915   -4.5101    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
    0.0000    3.0000    0.0000 C   0  0
    1.2982    3.7531    0.0000 N   0  0
    1.2961    5.2539    0.0000 C   0  0
    2.5925    6.0085    0.0000 C   0  0
    2.5873    7.5085    0.0000 C   0  0
    1.2856    8.2540    0.0000 C   0  0
   -0.0108    7.4995    0.0000 C   0  0
   -0.0056    5.9995    0.0000 C   0  0
    3.8837    8.2630    0.0000 Br  0  0
  1  2  1  0
  2  3  3  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 10 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16  9  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 20 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28807

> <plate>
Kinase v5-3

> <well>
O19

> <supplier_cmpd_name>
CL-387785 (EKI-785)

> <ctcr_id>
11514

> <supplier_cmpd_id>
S7557

> <smiles>
CC#CC(=O)Nc1cc2c(cc1)ncnc2Nc1cc(ccc1)Br

> <pd_targets>
{EGFR,ERBB4,ERBB2,ERBB3,SRC,ABCG2}

> <pathway_gtopdb>
{Enzyme,Transporter,Kinase,"Primary active transporter","Protein Kinase","ATP-binding cassette","TK protein kinase group","ABCG subfamily","Tyrosine protein kinase EGFR family","Tyrosine protein kinas
e Src family"}

> <pathway_chembl>
{Receptors,Transporters,"Catalytic receptors","ATP-binding cassette transporter family","Receptor kinases","ABCG subfamily","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyros
ine kinases (nRTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family","Src family"}

> <pathway_reactome>
{"Signal Transduction","Neuronal System","Developmental Biology",Metabolism,"Signaling by GPCR","Transmission across Chemical Synapses","Nervous system development","Signaling by Receptor Tyrosine Kin
ases","Abacavir transport and metabolism","GPCR downstream signalling","Neurotransmitter receptors and postsynaptic signal transmission","Axon guidance","Signaling by NTRKs","Abacavir transmembrane tr
ansport","G alpha (q) signalling events","Activation of NMDA receptors and postsynaptic events","Semaphorin interactions","Signaling by NTRK1 (TRKA)","Gastrin-CREB signalling pathway via PKC and MAPK"
,"Post NMDA receptor activation events","Sema4D in semaphorin signaling","Signalling to ERKs","EGFR Transactivation by Gastrin","Long-term potentiation","Sema4D induced cell migration and growth-cone 
collapse","Signalling to RAS","p38MAPK events"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{L38778,cl-387785,cl387785,194423-06-8,194423068,EKI-785,EKI785,"CL-387785 (EKI-785)","CL387785 (EKI785)","CL-387,785","CL387,785",N-(4-((3-bromophenyl)amino)quinazolin-6-yl)but-2-ynamide,N(4((3bromop
henyl)amino)quinazolin6yl)but2ynamide,N-(4-((3-Bromophenyl)amino)-6-quinazolinyl)-2-butynamide,N(4((3Bromophenyl)amino)6quinazolinyl)2butynamide,UNII-B4W27J1Z8B,UNIIB4W27J1Z8B,EKB-785,EKB785,"CL-38778
5(EKI785; WAY-EKI 785)","CL387785(EKI785; WAYEKI 785)",N-(4-(3-b,N(4(3b,T2245,CL-387785}

> <pdid>
PD012958

> <targets>
{EGFR}

> <classes>
{Angiogenesis,"JAK/STAT signaling","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{2776}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 O   0  0
   -3.8983   -0.7459    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 O   0  0
    1.3032   -3.7490    0.0000 C   0  0
    0.0000    3.0008    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -0.0048    6.0009    0.0000 C   0  0
    1.2954    5.2529    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    2.5981    3.0050    0.0000 C   0  0
   -2.6035    5.9971    0.0000 C   0  0
   -3.9026    5.2472    0.0000 C   0  0
   -5.2017    5.9972    0.0000 C   0  0
   -5.2017    7.4972    0.0000 C   0  0
   -3.9026    8.2472    0.0000 C   0  0
   -2.6036    7.4972    0.0000 C   0  0
   -6.5014    8.2475    0.0000 N   0  0
   -7.8017    7.4997    0.0000 C   0  0
   -9.0996    8.2517    0.0000 C   0  0
   -9.0972    9.7517    0.0000 N   0  0
   -7.7969   10.4997    0.0000 C   0  0
   -6.4991    9.7476    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  7 10  2  0
 10  3  1  0
 10 11  1  0
 11 12  1  0
  5 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 13  1  0
 18 19  1  0
 15 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 23 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
28808

> <plate>
Kinase v5-3

> <well>
O21

> <supplier_cmpd_name>
LDN-214117

> <ctcr_id>
11905

> <supplier_cmpd_id>
S7627

> <smiles>
COc1cc(cc(OC)c1OC)-c1cc(cnc1C)-c1ccc(cc1)N1CCNCC1

> <pd_targets>
{ACVR1,BMPR1A,TGFBR1,ACVRL1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase STKR family","TKL protein kinase STKR1","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","Receptor serine/threonine kinase (RSTK) family","Type I receptor serine/threonine kinases"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Signaling by TGFB family members","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by BMP","Signaling by TGF-beta Receptor 
Complex in Cancer","Loss of Function of SMAD2/3 in Cancer","SMAD2/3 Phosphorylation Motif Mutants in Cancer"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{DN21411,LDN-214117,LDN214117,1627503-67-6,1627503676,"1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine","1(4(6Methyl5(3,4,5trimethoxyphenyl)pyridin3yl)phenyl)piperazine",CHEMBL
3341789,"1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine","1(4(6methyl5(3,4,5trimethoxyphenyl)pyridin3yl)phenyl)piperazine",Piperazine,1-(4-(6-methyl-5-(3,1(4(6methyl5(3,4,5-tr
imethoxyp,5trimethoxyp,T1944}

> <pdid>
PD012399

> <targets>
{TGF-beta/Smad,ALK2}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{91754554}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 38  0  0  1  0            999 V2000
   -2.0017   -3.8204    0.0000 C   0  0
   -3.4500   -3.4300    0.0000 C   0  0
   -2.2500   -2.4700    0.0000 C   0  0  2  0  0  0
   -0.9100   -3.2400    0.0000 C   0  0
    0.4100   -2.4700    0.0000 C   0  0
    1.7107   -3.2171    0.0000 O   0  0
    0.4100   -0.9400    0.0000 C   0  0  2  0  0  0
   -0.9100   -0.1500    0.0000 C   0  0  1  0  0  0
   -2.2500   -0.9200    0.0000 C   0  0  1  0  0  0
   -3.4500    0.0300    0.0000 C   0  0
   -4.9600   -0.3000    0.0000 C   0  0
   -5.6500   -1.6600    0.0000 C   0  0
   -7.1499   -1.6430    0.0000 O   0  0
   -4.9600   -3.1000    0.0000 O   0  0
   -2.1390    0.5759    0.0000 C   0  0
   -0.9100    1.3600    0.0000 C   0  0
    0.4100    2.1300    0.0000 C   0  0
    1.7500    1.3600    0.0000 C   0  0  2  0  0  0
    1.7500   -0.1800    0.0000 C   0  0  2  0  0  0
    3.0900   -0.9400    0.0000 C   0  0  2  0  0  0
    1.7500   -1.7300    0.0000 O   0  0
    4.4300   -0.1500    0.0000 C   0  0
    5.7324   -0.8941    0.0000 O   0  0
    4.4300    1.3400    0.0000 O   0  0
    3.0900    2.1300    0.0000 C   0  0  1  0  0  0
    3.0984    3.6307    0.0000 C   0  0
    1.8935    4.5024    0.0000 C   0  0
    2.3710    5.9243    0.0000 O   0  0
    3.8710    5.9095    0.0000 C   0  0
    4.3204    4.4785    0.0000 C   0  0
    1.7500    2.8600    0.0000 C   0  0
    1.2741   -1.4433    0.0000 C   0  0
   -4.5747   -4.4224    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  1
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9  3  1  0
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14  2  1  0
  9 15  1  1
  8 16  1  1
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19  7  1  0
 19 20  1  0
 20 21  1  1
 19 21  1  1
 20 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 18  1  0
 25 26  1  6
 26 27  2  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 30 26  1  0
 18 31  1  6
  7 32  1  1
  2 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28809

> <plate>
Kinase v5-3

> <well>
O03

> <supplier_cmpd_name>
Obacunone

> <ctcr_id>
12393

> <supplier_cmpd_id>
S3784

> <smiles>
CC1([C@@H]2CC(=O)[C@@]3([C@@H]([C@]2(C=CC(=O)O1)C)CC[C@@]1([C@@]23[C@H](O2)C(=O)O[C@H]1c1cocc1)C)C)C

> <pd_targets>
{TGR}

> <pathway_gtopdb>
{Enzyme}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Obacunone,751-03-1,751031,OBACUNON,"Obacunoic acid, eta-lactone","Obacunoic acid, etalactone",AI3-37934,AI337934,CHEBI:7713,"Tricoccin S3",eta-lactone,etalactone,"CCRIS 8657","Tricoccin S3;",MLS00247
3187,"Obacunone, analytical standard",SCHEMBL564187,CHEMBL404140,DTXSID20996592,HMS2198M14,EX-A4868,EXA4868,HY,T3390}

> <pdid>
PD056590

> <targets>
{Aromatase,Nrf2,"p38 MAPK"}

> <classes>
{MAPK}

> <pubchem_cids>
{119041}

$$$$
UTKinase_V5
  SciTegic11012413002D

 17 18  0  0  0  0            999 V2000
    3.8805   -1.4410    0.0000 O   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 N   0  0
   -1.2947    3.7547    0.0000 N   0  0
   -1.2916    5.2556    0.0000 C   0  0
   -2.5886    6.0090    0.0000 O   0  0
    0.0092    6.0025    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
   -0.6923   -4.0811    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
  5 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  2  3
 14  3  1  0
 14 15  1  0
 15 16  1  0
 16  2  1  0
 15 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28810

> <plate>
Kinase v5-3

> <well>
O05

> <supplier_cmpd_name>
Carbazochrome

> <ctcr_id>
11763

> <supplier_cmpd_id>
S5084

> <smiles>
OC1C2=C/C(=N/NC(=O)N)/C(=O)C=C2N(C1)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{carbazochrome,69-81-8,69818,"Adrenochrome semicarbazone",Adrenostazin,Carbazochrom,Adedolon,Adchnon,Cromadrenal,Sangostasin,Sangostazin,Adrenoxyl,Adrezon,Adrokson,Adroxon,Cartabes,"Adrenochrome monos
emicarbazone",Adrenostan,Cromosil,"Adenocrome mo",T3616,Carbazochrome}

> <pdid>
PD000484

> <targets>
{Others,"myosin light-chain kinase",PLA2}

> <classes>
{Metabolism,Others}

> <pubchem_cids>
{2557}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  1  0            999 V2000
   12.5511   -3.4085    0.0000 C   0  0
   11.1261   -3.8768    0.0000 N   0  0
   10.3809   -3.2100    0.0000 C   0  0
   10.8181   -5.3457    0.0000 C   0  0
    9.3923   -5.8143    0.0000 C   0  0  1  0  0  0
    8.2760   -4.8112    0.0000 N   0  0
    8.5856   -3.3427    0.0000 C   0  0
    9.5362   -3.0324    0.0000 O   0  0
    7.4711   -2.3413    0.0000 N   0  0
    6.0049   -2.6577    0.0000 C   0  0
    5.2509   -1.3610    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 C   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 S   0  0
    0.0000   -1.5000    0.0000 C   0  0
    4.0324    0.7357    0.0000 N   0  0
    5.4987    1.0521    0.0000 N   0  0
    6.2511   -0.2432    0.0000 C   0  0
    7.6233   -0.8490    0.0000 C   0  0
    7.5962    0.6507    0.0000 C   0  0
    8.9134   -1.6142    0.0000 C   0  0
    9.0827   -7.2829    0.0000 C   0  0
   10.1970   -8.2871    0.0000 C   0  0
    9.8846   -9.7542    0.0000 C   0  0
    8.4578  -10.2172    0.0000 C   0  0
    7.3435   -9.2130    0.0000 C   0  0
    7.6559   -7.7459    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  5  4  1  6
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 14  1  0
 23 19  2  0
 12 24  2  0
 24 25  1  0
 25 26  1  0
 26 11  2  0
 26 27  1  0
 27  9  1  0
 27 28  1  0
 27 29  1  0
  5 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28811

> <plate>
Kinase v5-3

> <well>
O07

> <supplier_cmpd_name>
PF-3758309

> <ctcr_id>
8285

> <supplier_cmpd_id>
S7094

> <smiles>
CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)n[nH]c2C1(C)C)c5ccccc5

> <pd_targets>
{PAK4,PAK5,PAK1,PAK2,PAK3,PAK6}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","STE protein kinase STE20 family","STE protein kinase PAKB subfamily","STE protein kinase PAKA subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","STE20 family","PAKB subfamily","PAKA subfamily"}

> <pathway_reactome>
{"Developmental Biology",Disease,"Nervous system development","Infectious disease","Axon guidance","HIV Infection","Signaling by ROBO receptors","EPH-Ephrin signaling","Host Interactions of HIV factor
s","Activation of RAC1","EPHB-mediated forward signaling","The role of Nef in HIV-1 replication and disease pathogenesis","Ephrin signaling","Nef and signal transduction"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{PF3758309,"PF 3758309",898044-15-0,898044150,"898044 15 0",PF-03758309,PF03758309,"PF 03758309",UNII-PK459EA5I2,UNIIPK459EA5I2,"UNII PK459EA5I2",PK459EA5I2,CHEMBL3128043,"898044-15-0 (free base)","89
8044150 (free base)","898044 15 0 (free bas",S7094,PF-3758309,"PF 3758309 dihydrochloride"}

> <pdid>
PD003674

> <targets>
{PAK,Apoptosis}

> <classes>
{Apoptosis,Cell Cycle/DNA Damage,Cytoskeleton}

> <pubchem_cids>
{25227462}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 23  0  0  0  0            999 V2000
    4.6379    5.2745    0.0000 Br  0  0
    4.3480    3.8028    0.0000 C   0  0
    5.4777    2.8159    0.0000 C   0  0
    5.1878    1.3442    0.0000 C   0  0
    3.7691    0.8603    0.0000 C   0  0
    3.1796   -0.5190    0.0000 N   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.5242    2.0130    0.0000 O   0  0
   -1.6852   -0.3847    0.0000 N   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.5000   -2.8577    0.0000 C   0  0
   -0.7500   -4.1567    0.0000 C   0  0
    0.7500   -4.1567    0.0000 C   0  0
    1.5000   -2.8577    0.0000 N   0  0
    0.7500   -1.5574    0.0000 C   0  0
    2.6395    1.8472    0.0000 C   0  0
    2.9286    3.3180    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  7  1  0
 18 13  1  0
  8 19  1  0
 19  5  1  0
 19 20  2  0
 20  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28812

> <plate>
Kinase v5-3

> <well>
O09

> <supplier_cmpd_name>
1-Azakenpaullone

> <ctcr_id>
2174

> <supplier_cmpd_id>
S7193

> <smiles>
Brc1ccc2[nH]c3c(CC(=O)Nc4cccnc34)c2c1

> <pd_targets>
{GSK3A,CDK1,GSK3B,CCNB1,CCNB2,CCNB3,CSNK2A1,ABL1,PIM1,FLT4,CDK5,LCK,CDK5R1,CDK2,FYN,DYRK1A}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","TK protein kinase group","CAMK protein kinase group","CMGC protein kinase GSK family","CMGC protein kinase CDK
 family","Other protein kinase CK2 family","Tyrosine protein kinase Abl family","CAMK protein kinase PIM family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src family","CMGC prote
in kinase DYRK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily","Tyrosine protein kinase SrcA","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinases","Glycogen syntha
se kinase (GSK) family","Cyclin-dependent kinase (CDK) family","Other protein kinases","TK: Tyrosine kinase","PIM family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family"
,"GSK subfamily","CDK1 subfamily","Casein kinase 2 (CK2) family","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","CDK5 subfamily","Dyrk1 subfamily","Abl family","Type IV RTK
s: VEGF (vascular endothelial growth factor) receptor family","Src family"}

> <pathway_reactome>
{Disease,"Cell Cycle","Gene expression (Transcription)","Signal Transduction","Infectious disease",Mitotic,"RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors
 and second messengers","Signaling by Receptor Tyrosine Kinases","SARS-CoV Infections","Regulation of mitotic cell cycle","Generic Transcription Pathway","Leishmania infection","FLT3 signaling in dise
ase","Signaling by VEGF","HIV Infection","Mitotic G1 phase and G1/S transition","SARS-CoV-1 Infection","APC/C-mediated degradation of cell cycle proteins","Transcriptional Regulation by TP53","Parasit
e infection","Signaling by FLT3 ITD and TKD mutants","VEGF ligand-receptor interactions","Host Interactions of HIV factors","G0 and Early G1","SARS-CoV-1 Genome Replication and Transcription","Activat
ion of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Regulation of TP53 Activity","Leishmania phagocytosis","STAT5 activation downstream of FLT3 ITD mutants","VEGF binds to VEGFR le
ading to receptor dimerization","The role of Nef in HIV-1 replication and disease pathogenesis","Replication of the SARS-CoV-1 genome","APC/C:Cdc20 mediated degradation of mitotic proteins","Regulatio
n of TP53 Activity through Phosphorylation","FCGR3A-mediated phagocytosis","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Regulation of TP53 Expressi
on and Degradation","Nef and signal transduction","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Nef Mediated CD4 Down-regulation","Regulati
on of TP53 Degradation","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
{CCNB1,CDK1,CDK5,GSK3B}

> <broad_moa>
{"glycogen synthase kinase inhibitor"}

> <synonyms>
{1-Azakenpaullone,1Azakenpaullone,676596-65-9,676596659,azakenpaullone,1-AKP,1AKP,"9-bromo-7,12-dihydropyrido(3',2':2,3)azepino(4,5-b)indol-6(5H)-one","9bromo7,12dihydropyrido(3',2':2,3)azepino(4,5b)i
ndol6(5H)one",C15H10BrN3O,"9-bromo-7,12-dihydro-pyrido(3',2':2,3)azepino(4,5-b)indol-6(5H)-one",Kinome_3492,Kinome3492,Kinome-3492,"Kinome 3492",SCHEMBL378920,BDBM7497,CHEMBL336961,"EMD 191500",191500
}

> <pdid>
PD010396

> <targets>
{GSK-3,1-Azakenpaullone}

> <classes>
{}

> <pubchem_cids>
{6538897}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 44  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    2.5981    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 N   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -6.4930   -3.7570    0.0000 C   0  0
   -7.8464   -3.1403    0.0000 C   0  0
   -8.8465   -4.2582    0.0000 N   0  0
   -8.0924   -5.5548    0.0000 C   0  0
   -6.6262   -5.2383    0.0000 S   0  0
   -3.9015    0.7475    0.0000 Cl  0  0
    3.8963    3.7531    0.0000 N   0  0
    3.8941    5.2539    0.0000 C   0  0
    5.1905    6.0085    0.0000 C   0  0
    5.1853    7.5085    0.0000 C   0  0
    3.8837    8.2540    0.0000 C   0  0
    2.5873    7.4995    0.0000 C   0  0
    2.5925    5.9995    0.0000 C   0  0
    3.8785    9.7548    0.0000 N   0  0
    5.1737   10.5114    0.0000 C   0  0
    5.1661   12.0114    0.0000 C   0  0
    3.8633   12.7548    0.0000 N   0  0
    2.5681   11.9983    0.0000 C   0  0
    2.5757   10.4983    0.0000 C   0  0
    3.8557   14.2548    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12  3  1  0
 12 13  2  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 20  1  0
 15 25  1  0
  6 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 30 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 33  1  0
 36 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28813

> <plate>
Kinase v5-3

> <well>
O11

> <supplier_cmpd_name>
FRAX597

> <ctcr_id>
12963

> <supplier_cmpd_id>
Se S7271

> <smiles>
CCn1c2nc(ncc2cc(c1=O)c1c(cc(cc1)c1cncs1)Cl)Nc1ccc(cc1)N1CCN(CC1)C

> <pd_targets>
{PAK1,PAK3,PAK4,PAK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","STE protein kinase STE20 family","STE protein kinase PAKA subfamily","STE protein kinase PAKB subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","STE20 family","PAKA subfamily","PAKB subfamily"}

> <pathway_reactome>
{"Developmental Biology",Disease,"Nervous system development","Infectious disease","Axon guidance","HIV Infection","EPH-Ephrin signaling","Signaling by ROBO receptors","Host Interactions of HIV factor
s","EPHB-mediated forward signaling","Ephrin signaling","Activation of RAC1","The role of Nef in HIV-1 replication and disease pathogenesis","Nef and signal transduction"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{FRAX597,1286739-19-2,1286739192,"FRAX 597",FRAX-597,CHEMBL3609327,GTPL8939,SCHEMBL13554062,HMS3673K09,BCP12649,EX-A2219,EXA2219,BDBM50112347,HY-15542A,HY15542A,MFCD25976723,s7271,ZINC98209617,AKOS025
404924,CCG-270039,CCG270039,CS-1977,CS1977,SB19060,NCGC00389582-01,NCGC0038958201,NCGC00389582-02,NCGC0038958202,AC-29026,AC29026,A,T6014}

> <pdid>
PD021548

> <targets>
{PAK,PAK1,PAK2,PAK3}

> <classes>
{"Cytoskeletal Signaling"}

> <pubchem_cids>
{70934541}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    7.7969   -1.5132    0.0000 S   0  0
    7.7919   -3.0132    0.0000 O   0  0
    6.4955   -2.2591    0.0000 O   0  0
    6.4994   -0.7589    0.0000 N   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 O   0  0
   -4.6588   -2.9478    0.0000 O   0  0
   -5.1253   -4.3743    0.0000 C   0  0
   -6.5929   -4.6844    0.0000 C   0  0
    9.0994   -0.7675    0.0000 C   0  0
   10.3957   -1.5223    0.0000 C   0  0
   11.6974   -0.7770    0.0000 C   0  0
   11.7029    0.7230    0.0000 C   0  0
   10.4066    1.4777    0.0000 C   0  0
    9.1048    0.7325    0.0000 C   0  0
  1  2  2  0
  1  3  2  0
  1  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  7 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 11  2  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 14  2  0
 17 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  1  0
  1 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28814

> <plate>
Kinase v5-3

> <well>
O13

> <supplier_cmpd_name>
HS-173

> <ctcr_id>
11411

> <supplier_cmpd_id>
S7356

> <smiles>
S(=O)(=O)(Nc1cc(cnc1)c1ccc2n(c1)c(cn2)C(=O)OCC)c1ccccc1

> <pd_targets>
{PIK3CB,PIK3CA,PIK3CD,PIK3R1,PIK3CG}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{"Signal Transduction",Disease,Metabolism,"Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","Signaling 
by Insulin receptor","Signaling by FGFR in disease","Phospholipid metabolism","Insulin receptor signalling cascade","Signaling by FGFR1 in disease","PI Metabolism","IRS-mediated signalling","FGFR1 mut
ant receptor activation","Synthesis of PIPs at the plasma membrane","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{S17,HS-173,HS173,1276110-06-5,1276110065,CHEMBL1765463,"HS 173",GTPL8243,SCHEMBL20768095,AOB6845,EX-A320,EXA320,HMS3653I16,BCP09225,2465AH,BDBM50341493,MFCD28023584,s7356,ZINC71319188,AKOS026750419,A
CN-053037,ACN053037,CCG-268913,CCG268913,CS-6015,CS6015,SB19242,NCGC00386329-02,NCGC0038632902,AK474032,AS-74644,AS74644,T2308}

> <pdid>
PD010339

> <targets>
{PI3K,PI3K¦Á}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{52936849}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  1  0            999 V2000
    9.8941   -8.8675    0.0000 C   0  0
   10.0994   -7.3817    0.0000 N   0  0
    9.0370   -6.3477    0.0000 C   0  0
    9.6577   -4.9951    0.0000 C   0  0
   11.1448   -5.1913    0.0000 C   0  0
   11.4178   -6.6662    0.0000 N   0  0
    8.9324   -3.6822    0.0000 Cl  0  0
    7.5445   -6.5046    0.0000 C   0  0
    6.7945   -7.8036    0.0000 C   0  0
    5.3273   -7.4917    0.0000 O   0  0
    5.1894   -6.0109    0.0000 C   0  0
    6.5408   -5.3899    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    2.5909   -6.0056    0.0000 O   0  0
    3.8933   -3.7570    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0  1  0  0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
    0.0000    3.0000    0.0000 F   0  0
    1.2925   -3.7494    0.0000 C   0  0
   -0.0041   -2.9953    0.0000 N   0  0
    7.4046   -9.1739    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  4  7  1  0
  3  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12  8  1  0
 11 13  1  0
 13 14  2  0
 13 15  1  0
 16 15  1  6
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 21 24  1  0
 20 25  1  0
 16 26  1  0
 26 27  1  0
  9 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28815

> <plate>
Kinase v5-3

> <well>
O15

> <supplier_cmpd_name>
Uprosertib (GSK2141795)

> <ctcr_id>
12594

> <supplier_cmpd_id>
S7492

> <smiles>
Cn1c(c(cn1)Cl)c1c(oc(c1)C(=O)N[C@@H](Cc1cc(c(cc1)F)F)CN)Cl

> <pd_targets>
{RPS6KB1,AKT1,AKT3,ROCK1,AKT2,SGK1,RPS6KA1,PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCI,PRKCQ,PRKCZ,PRKD1,PRKD3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase RSK family","AGC protein kinase AKT family","AGC protein kinase DMPK family","AGC protein kinase SGK family","AGC protein
 kinase PKC family","AGC protein kinase p70 subfamily","AGC protein kinase ROCK subfamily","AGC protein kinase RSK subfamily","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","RSK family","Akt (Protein kinase B","PKB) family","DMPK family","SGK family","p70 subfamily","Rho kinase","RSK subfamily"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Developmental Biology","Immune System","MTOR signalling","RNA Polymerase II Transcription","Nervous system development","Signaling by Receptor
 Tyrosine Kinases","Innate Immune System","mTORC1-mediated signalling","Generic Transcription Pathway","Axon guidance","Signaling by Insulin receptor","Toll-like Receptor Cascades","Transcriptional Re
gulation by TP53","Semaphorin interactions","Insulin receptor signalling cascade","Toll Like Receptor 5 (TLR5) Cascade","Regulation of TP53 Activity","Sema4D in semaphorin signaling","IRS-mediated sig
nalling","MyD88 cascade initiated on plasma membrane","Regulation of TP53 Expression and Degradation","Sema4D induced cell migration and growth-cone collapse","PI3K Cascade","MAP kinase activation","R
egulation of TP53 Degradation","PKB-mediated events","MAPK targets/ Nuclear events mediated by MAP kinases","PDE3B signalling","CREB phosphorylation"}

> <broad_targets>
{AKT1,AKT2,AKT3}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{Uprosertib,1047634-65-0,1047634650,GSK2141795,UNII-ZXM835LQ5E,UNIIZXM835LQ5E,"Uprosertib (GSK2141795)",GSK2141795C,GSK-2141795,ZXM835LQ5E,GSK795,"Uprosertib (USAN:INN)","Uprosertib (USAN/INN)",SCHEMB
L168584,"Uprosertib, GSK2141795",GTPL7902,CHEMBL3137336,BCP28204,EX-A15,EXA15,T6849}

> <pdid>
PD047342

> <targets>
{Akt,Akt1,Akt2,Akt3}

> <classes>
{"Cytoskeletal Signaling","PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{51042438}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 O   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -7.7985    2.9932    0.0000 C   0  0
   -9.0998    3.7409    0.0000 C   0  0
  -10.3985    2.9886    0.0000 C   0  0
  -10.3933    1.4885    0.0000 C   0  0
  -11.6898    0.7340    0.0000 N   0  0
  -12.9914    1.4795    0.0000 C   0  0
  -14.2878    0.7249    0.0000 N   0  0
  -12.9966    2.9795    0.0000 N   0  0
  -11.7002    3.7340    0.0000 C   0  0
  -11.7055    5.2340    0.0000 N   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -6.5025   -0.7576    0.0000 O   0  0
   -7.8026   -1.5058    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 14  1  0
 20 21  1  0
 12 22  1  0
 22 23  2  0
 23  9  1  0
 23 24  1  0
 24 25  1  0
  6 26  1  0
 26 27  2  0
 27  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28818

> <plate>
Kinase v5-3

> <well>
A20

> <supplier_cmpd_name>
GW2580

> <ctcr_id>
2789

> <supplier_cmpd_id>
S8042

> <smiles>
COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1

> <pd_targets>
{NTRK3,NTRK1,NTRK2,CSF1R}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Trk family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type VII RTKs: Neurotrophin receptor/Trk family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 rec
eptor family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Signaling by NTRKs","Generic Transcription Pathway","Signaling by N
TRK3 (TRKC)","Signaling by NTRK1 (TRKA)","Transcriptional Regulation by VENTX","Activated NTRK3 signals through PI3K","Signalling to ERKs","Activation of TRKA receptors","Prolonged ERK activation even
ts","NGF-independant TRKA activation","ARMS-mediated activation"}

> <broad_targets>
{CSF1R}

> <broad_moa>
{"cFMS kinase inhibitor"}

> <synonyms>
{GW2580,870483-87-7,870483877,GW-2580,"cFMS Receptor Tyrosine Kinase Inhibitor","GW 2580",UNII-SRV0JCF9LI,UNIISRV0JCF9LI,GW632580X,"5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine",
"5(3Methoxy4((4methoxybenzyl)oxy)benzyl)pyrimidine2,4diamine",SRV0JCF9LI,5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,5(3methoxy4((4methoxybenzyl)oxy)benzyl)pyrimidine2,4-dia,4dia,T2659,"E
MD 344036",344036}

> <pdid>
PD003236

> <targets>
{CSF-1R}

> <classes>
{}

> <pubchem_cids>
{11617559}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 N   0  0
    2.5847   -6.0040    0.0000 C   0  0
    2.5795   -7.5040    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -1.2991    5.2500    0.0000 O   0  0
    0.0000    3.0000    0.0000 N   0  0
    1.2990    3.7500    0.0000 C   0  0
   -3.8978    3.7504    0.0000 C   0  0
   -3.8955    5.2504    0.0000 C   0  0
   -5.1934    6.0025    0.0000 C   0  0
   -6.4936    5.2545    0.0000 C   0  0
   -6.4960    3.7545    0.0000 C   0  0
   -5.1981    3.0025    0.0000 C   0  0
   -5.2005    1.5025    0.0000 C   0  0
   -5.1941    7.5033    0.0000 N   0  0
   -6.4937    8.2539    0.0000 C   0  0
   -7.7926    7.5037    0.0000 O   0  0
   -6.4944    9.7547    0.0000 C   0  0
   -7.7923   10.5069    0.0000 C   0  0
   -7.7900   12.0069    0.0000 C   0  0
   -6.4898   12.7548    0.0000 C   0  0
   -5.1919   12.0028    0.0000 C   0  0
   -5.1942   10.5028    0.0000 C   0  0
   -3.8910   12.7512    0.0000 C   0  0
   -3.8877   14.2512    0.0000 F   0  0
   -2.5933   11.9988    0.0000 F   0  0
   -2.5904   13.4986    0.0000 F   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  6  7  1  0
  3  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 12 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 11  1  0
 19 20  1  0
 16 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 26 27  1  0
 23 28  1  0
 28 29  1  0
 29 30  2  0
 29 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 31  1  0
 35 37  1  0
 37 38  1  0
 37 39  1  0
 37 40  1  0
M  END
> <name>
UTKinase_V5

> <id>
28819

> <plate>
Kinase v5-3

> <well>
A22

> <supplier_cmpd_name>
GNF-7

> <ctcr_id>
11993

> <supplier_cmpd_id>
S8140

> <smiles>
c1cc(cnc1C)Nc1nc2c(cn1)CN(C(=O)N2C)c1cc(ccc1C)NC(=O)c1cccc(c1)C(F)(F)F

> <pd_targets>
{ABL1,BCR,TNK2,MAP4K2,BMX}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","TK protein kinase group","STE protein kinase group","Atypical protein kinase BCR family","Tyrosine protein kinase Ack family","STE prot
ein kinase STE20 family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Tec family","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","STE20 family","Non-recept
or tyrosine kinases (nRTKs)","KHS subfamily","Ack family","Abl family","Tec family"}

> <pathway_reactome>
{Disease,Metabolism,"Infectious disease","Metabolism of lipids","Leishmania infection","Phospholipid metabolism","Parasite infection","PI Metabolism","Leishmania phagocytosis","Synthesis of PIPs at th
e plasma membrane","FCGR3A-mediated phagocytosis"}

> <broad_targets>
{GCK,TNK2}

> <broad_moa>
{"glucokinase inhibitor","protein kinase inhibitor"}

> <synonyms>
{NF,GNF-7,GNF7,839706-07-9,839706079,"GNF 7",CHEMBL1214141,"CID 11478363",SCHEMBL3135042,EX-A826,EXA826,BCP17217,BDBM50323777,MFCD18251569,s8140,ZINC58541155,AKOS025291029,CCG-269989,CCG269989,CS-5551
,CS5551,PB34926,NCGC00476210-01,NCGC0047621001,AC-32985,AC32985,HY-10943,HY10943,DS-017358,DS017358,Q-4515,Q4515,T3196}

> <pdid>
PD038142

> <targets>
{Bcr-Abl,M351T,c-Abl,E255V,G250E,T315I}

> <classes>
{Angiogenesis,Neuroscience,"Cytoskeletal Signaling"}

> <pubchem_cids>
{11478363}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  1  0            999 V2000
   -2.6363  -10.5064    0.0000 C   0  0
   -1.3345   -9.7613    0.0000 C   0  0  2  0  0  0
   -0.0383  -10.5162    0.0000 C   0  0
    1.2636   -9.7711    0.0000 O   0  0
    1.2693   -8.2711    0.0000 C   0  0
   -0.0269   -7.5162    0.0000 C   0  0
   -1.3289   -8.2612    0.0000 N   0  0
   -2.6245   -7.5039    0.0000 C   0  0
   -3.9276   -8.2469    0.0000 C   0  0
   -5.2226   -7.4899    0.0000 C   0  0
   -6.5256   -8.2329    0.0000 O   0  0
   -5.2145   -5.9899    0.0000 N   0  0
   -6.5095   -5.2330    0.0000 C   0  0
   -6.5014   -3.7330    0.0000 C   0  0
   -5.1984   -2.9900    0.0000 C   0  0  2  0  0  0
   -3.9034   -3.7469    0.0000 N   0  0
   -2.6011   -3.0008    0.0000 C   0  0
   -1.3034   -3.7547    0.0000 C   0  0
   -1.3043   -5.2548    0.0000 C   0  0
   -0.0057   -6.0056    0.0000 N   0  0
    1.2938   -5.2565    0.0000 C   0  0
    1.2948   -3.7565    0.0000 C   0  0
    2.5943   -3.0073    0.0000 Cl  0  0
   -0.0038   -3.0056    0.0000 C   0  0
   -3.9115   -5.2469    0.0000 C   0  0
   -2.6165   -6.0039    0.0000 N   0  0
   -5.1903   -1.4892    0.0000 C   0  0
   -6.4848   -0.7314    0.0000 F   0  0
   -3.8870   -0.7466    0.0000 F   0  0
   -5.1815    0.0108    0.0000 F   0  0
  2  1  1  1
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 24 18  1  0
 16 25  1  0
 25 12  1  0
 25 26  2  3
 26  8  1  0
 15 27  1  1
 27 28  1  0
 27 29  1  0
 27 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28821

> <plate>
Kinase v5-3

> <well>
A06

> <supplier_cmpd_name>
SAR405

> <ctcr_id>
15504

> <supplier_cmpd_id>
S7682

> <smiles>
C[C@@H]1COCCN1C2=CC(=O)N3CC[C@H](N(Cc4cncc(Cl)c4)C3=N2)C(F)(F)F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HY-12481,SAR405,SAR405}

> <pdid>
PD013365

> <targets>
{PI3K,Autophagy}

> <classes>
{Autophagy,PI3K/Akt/mTOR}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 15 15  0  0  0  0            999 V2000
    6.4897   -5.2632    0.0000 O   0  0
    5.1894   -6.0109    0.0000 C   0  0
    5.1873   -7.5109    0.0000 O   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Br  0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15  9  1  0
M  END
> <name>
UTKinase_V5

> <id>
28822

> <plate>
Kinase v5-3

> <well>
A08

> <supplier_cmpd_name>
Bikinin

> <ctcr_id>
11413

> <supplier_cmpd_id>
S7722

> <smiles>
OC(=O)CCC(=O)Nc1ncc(Br)cc1

> <pd_targets>
{TSHR,RORC,AMPC}

> <pathway_gtopdb>
{"Membrane receptor","Transcription factor",Enzyme,"Family A G protein-coupled receptor","Nuclear receptor",Hydrolase,"Peptide receptor (family A GPCR)","Nuclear hormone receptor subfamily 1","Glycoho
rmone receptor","Nuclear hormone receptor subfamily 1 group F","Nuclear hormone receptor subfamily 1 group F member 3"}

> <pathway_chembl>
{Receptors,"G protein-coupled receptors","Nuclear hormone receptors","Glycoprotein hormone receptors","1F. Retinoic acid-related orphans"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Infectious disease","RNA Polymerase II Transcription","Leishmania infection","Generic Transcription Pathway","Leishmania parasite growth and survival","Tran
scriptional regulation by RUNX3","Anti-inflammatory response favouring Leishmania parasite infection","RUNX3 Regulates Immune Response and Cell Migration","ADORA2B mediated anti-inflammatory cytokines
 production"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Bikinin,188011-69-0,188011690,"4-((5-Bromopyridin-2-yl)amino)-4-oxobutanoic acid","4((5Bromopyridin2yl)amino)4oxobutanoic acid","4-((5-bromopyridin-2-yl)amino)-4-oxobutanoic acid","4((5bromopyridin2y
l)amino)4oxobutanoic acid",Abrasin,"N-(5-Bromo-pyridin-2-yl)-succinamic acid","N(5Bromopyridin2yl)succinamic acid","n-(5-bromopyridin-2-yl)succinamic acid","n(5bromopyridin2yl)succinamic acid",3-(N-(5
-bromo-2-pyridyl)carbam,3(N(5bromo2pyridyl)carbam,T1965}

> <pdid>
PD004311

> <targets>
{GSK-3,"Shaggy-like kinase"}

> <classes>
{"PI3K/Akt/mTOR signaling",Others,"Stem Cells"}

> <pubchem_cids>
{647833}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
    5.2311   -3.4009    0.0000 C   0  0
    3.8056   -3.8679    0.0000 N   0  0
    3.3372   -5.2929    0.0000 N   0  0
    1.8372   -5.2877    0.0000 C   0  0
    0.9513   -6.4982    0.0000 C   0  0
    1.3786   -3.8595    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -6.4948    0.7483    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -9.0951    0.7465    0.0000 N   0  0
  -10.3950    1.4967    0.0000 C   0  0
  -10.3948    2.9967    0.0000 O   0  0
  -11.6951    0.7469    0.0000 C   0  0
  -12.9954    1.4948    0.0000 C   0  0
  -14.2932    0.7427    0.0000 C   0  0
  -14.2909   -0.7573    0.0000 C   0  0
  -12.9907   -1.5052    0.0000 C   0  0
  -11.6928   -0.7532    0.0000 C   0  0
  -12.9883   -3.0061    0.0000 C   0  0
  -14.2857   -3.7589    0.0000 F   0  0
  -11.6879   -3.7536    0.0000 F   0  0
  -12.9853   -4.5061    0.0000 F   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -6.4995    3.7483    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -3.9015    3.7525    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  4  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 17 19  1  0
 19 12  1  0
 19 20  2  0
 20  9  1  0
 14 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 25 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 31 33  1  0
 33 34  1  0
 33 35  1  0
 33 36  1  0
 23 37  2  0
 37 38  1  0
 38 39  2  0
 39 21  1  0
 39 40  1  0
M  END
> <name>
UTKinase_V5

> <id>
28823

> <plate>
Kinase v5-3

> <well>
A10

> <supplier_cmpd_name>
Pluripotin (SC1)

> <ctcr_id>
8334

> <supplier_cmpd_id>
S7752

> <smiles>
Cn1nc(C)cc1Nc2ncc3CN(C(=O)N(C)c3n2)c4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C

> <pd_targets>
{TNK2,MAP4K2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","STE protein kinase group","Tyrosine protein kinase Ack family","STE protein kinase STE20 family","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TK: Tyrosine kinase","STE20 family","Non-recept
or tyrosine kinases (nRTKs)","KHS subfamily","Ack family"}

> <pathway_reactome>
{}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Pluripotin,839707-37-8,839707378,CHEMBL4213673,C27H25F3N8O2,"Pluripotin (SC1)",SC1(Pluripotin),"Stemolecule SC 1",MLS006010719,SCHEMBL3135215,"Pluripotin, >=98 (HPLC)",BCP02463,EX-A1260,EXA1260,BDBM5
0459216,MFCD20527253,NSC763525,s7752,ZINC38141704,AKOS024458159,T6948,4433}

> <pdid>
PD003293

> <targets>
{ERK}

> <classes>
{}

> <pubchem_cids>
{12003241}

$$$$
UTKinase_V5
  SciTegic11012413002D

 50 51  0  0  1  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    1.2990   -3.7500    0.0000 N   0  0
    2.5981   -3.0000    0.0000 C   0  0
    2.5981   -1.5000    0.0000 N   0  0
   -1.2982   -3.7531    0.0000 N   0  0
   -1.2961   -5.2539    0.0000 C   0  0
   -2.5925   -6.0085    0.0000 C   0  0
   -2.5873   -7.5085    0.0000 C   0  0
   -1.2857   -8.2540    0.0000 C   0  0
    0.0108   -7.4995    0.0000 C   0  0
    0.0056   -5.9995    0.0000 C   0  0
   -1.2805   -9.7540    0.0000 F   0  0
   -3.8837   -8.2630    0.0000 Cl  0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7545    0.0000 O   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4990    0.7409    0.0000 C   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0990    0.7364    0.0000 N   0  0
  -10.3996    1.4837    0.0000 C   0  0
   -9.0964   -0.7636    0.0000 C   0  0
    0.0031    3.0008    0.0000 O   0  0
    1.3039    3.7494    0.0000 C   0  0  1  0  0  0
    1.4469    5.2298    0.0000 C   0  0
    2.9152    5.5365    0.0000 C   0  0
    3.6607    4.2349    0.0000 O   0  0
    2.6531    3.1237    0.0000 C   0  0
   10.0607   -1.7341    0.0000 C   0  0
    8.7607   -2.4841    0.0000 C   0  0
    8.7592   -3.9849    0.0000 C   0  0
    7.4600   -4.7345    0.0000 O   0  0
   10.0578   -4.7358    0.0000 O   0  0
   11.3606   -2.4841    0.0000 C   0  0
   12.6599   -1.7345    0.0000 O   0  0
   11.3606   -3.9841    0.0000 O   0  0
   19.0606   -1.7341    0.0000 C   0  0
   17.7606   -2.4841    0.0000 C   0  0
   17.7592   -3.9849    0.0000 C   0  0
   16.4599   -4.7345    0.0000 O   0  0
   19.0577   -4.7358    0.0000 O   0  0
   20.3606   -2.4841    0.0000 C   0  0
   21.6599   -1.7345    0.0000 O   0  0
   20.3606   -3.9841    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  1  1  0
  7 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 14 19  1  0
  4 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 26 28  1  0
  3 29  1  0
 30 29  1  1
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 30  1  0
 35 36  2  0
 36 37  1  0
 37 38  2  0
 37 39  1  0
 35 40  1  0
 40 41  2  0
 40 42  1  0
 43 44  2  0
 44 45  1  0
 45 46  2  0
 45 47  1  0
 43 48  1  0
 48 49  2  0
 48 50  1  0
M  END
> <name>
UTKinase_V5

> <id>
28824

> <plate>
Kinase v5-3

> <well>
A12

> <supplier_cmpd_name>
Afatinib (BIBW2992) Dimaleate

> <ctcr_id>
11187

> <supplier_cmpd_id>
S7810

> <smiles>
c12cc(c(cc1c(ncn2)Nc1cc(c(cc1)F)Cl)NC(=O)/C=C/CN(C)C)O[C@H]1CCOC1.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"AFATINIB DIMALEATE",850140-73-7,850140737,"Afatinib (diMaleate)",Gilotrif,"Afatinib maleate",UNII-V1T5K7RZ0B,UNIIV1T5K7RZ0B,"Afatinib dimaleate (USAN)",V1T5K7RZ0B,"BIBW 2992MA2","Afatinib (BIBW2992)
 Dimaleate","BIBW2992 MA2",CHEBI:76003,"850140-73-7 (dimalea","850140737 (dimalea",T1773,"Afatinib Dimaleate"}

> <pdid>

> <targets>
{EGFR,HER2,"EGFR (L858R)","EGFR (L858R/T790M)","EGFR (wt)"}

> <classes>
{Angiogenesis,"JAK/STAT signaling","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{15606394}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 F   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 F   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -5.1969    1.4963    0.0000 N   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -3.9014    3.7484    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -1.3027    3.7529    0.0000 C   0  0
   -0.0012    3.0071    0.0000 C   0  0
    1.2954    3.7612    0.0000 C   0  0
    1.2906    5.2612    0.0000 C   0  0
   -0.0108    6.0071    0.0000 C   0  0
   -1.3074    5.2530    0.0000 C   0  0
    2.5879    6.0157    0.0000 N   0  0
    3.8906    5.2720    0.0000 C   0  0
    5.1861    6.0282    0.0000 C   0  0
    5.1789    7.5282    0.0000 O   0  0
    3.8763    8.2720    0.0000 C   0  0
    2.5809    7.5158    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  6 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 19 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28825

> <plate>
Kinase v5-3

> <well>
A14

> <supplier_cmpd_name>
LJI308

> <ctcr_id>
12799

> <supplier_cmpd_id>
S7871

> <smiles>
Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1

> <pd_targets>
{RPS6KA3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase RSK family","AGC protein kinase RSK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","RSK family","RSK subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","CREB phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{LJI308,1627709-94-7,1627709947,LJI-308,CHEMBL3604794,"2,6-Difluoro-4-(4-(4-(4-morpholinyl)phenyl)-3-pyridinyl)-phenol","2,6Difluoro4(4(4(4morpholinyl)phenyl)3pyridinyl)phenol",SCHEMBL22374661,BCP2414
9,EX-A2325,EXA2325,BDBM50111384,s7871,ZINC334163679,CCG-268264,CCG268264,CS-5380,CS5380,AC-32954,AC32954,BS-15508,BS15508,HY-19713,HY19713,"LJI308, >=98 (HPLC)",A1437,T6878}

> <pdid>
PD071551

> <targets>
{"S6 Kinase",RSK1,RSK2,RSK3}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{118704762}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
    5.1932   -3.0130    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.4133    1.7530    0.0000 N   0  0
    1.8032    3.1233    0.0000 C   0  0
    0.3114    2.9665    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -5.1984   -1.4978    0.0000 C   0  0
   -6.4971   -0.7455    0.0000 C   0  0
   -7.7988   -1.4910    0.0000 C   0  0
   -9.0952   -0.7365    0.0000 C   0  0
   -9.0900    0.7635    0.0000 C   0  0
   -7.7884    1.5090    0.0000 C   0  0
   -6.4920    0.7546    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  3
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 10  1  0
 14 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  3
 21 22  1  0
 22 23  2  3
 23 24  1  0
 24 25  2  3
 25 20  1  0
 18 26  1  0
 26 27  1  0
 27 15  1  0
 16 28  1  0
 28  9  1  0
 28 29  2  0
M  END
> <name>
UTKinase_V5

> <id>
28827

> <plate>
Kinase v5-3

> <well>
A18

> <supplier_cmpd_name>
TIC10

> <ctcr_id>
12995

> <supplier_cmpd_id>
S7963

> <smiles>
CC1=CC=CC=C1CN1C2=NCCN2C2=C(CN(CC3=CC=CC=C3)CC2)C1=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{TNFSF10}

> <broad_moa>
{"AKT inhibitor","MAP kinase inhibitor"}

> <synonyms>
{1616632-77-9,1616632779,"ONC 201",ONC-201,ONC201,UNII-9U35A31JAI,UNII9U35A31JAI,9U35A31JAI,"ONC-201 (TIC-10)","ONC201 (TIC10)",MFCD28118993,"1616632-77-9 (free base)","1616632779 (free base)","Active
 isomer 2","TIC10 compound",GTPL9978,CHEMBL4297310,SCHEMBL16227974,AOB2892,EX-A669,EXA669,HMS3874G13,BCP14991,3388AH,HY-15615,HY15615,T7001,TIC10}

> <pdid>
PD012547

> <targets>
{Akt,Others}

> <classes>
{Others}

> <pubchem_cids>
{73777259}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 20  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1065    0.0000    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6588   -2.9478    0.0000 C   0  0
   -5.2521   -4.3116    0.0000 C   0  0
   -6.7433   -4.1499    0.0000 N   0  0
   -7.0504   -2.6817    0.0000 C   0  0
   -5.7489   -1.9360    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 12  1  0
 10 17  1  0
 17  6  1  0
 17 18  2  0
 18  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28828

> <plate>
Kinase v5-3

> <well>
D08

> <supplier_cmpd_name>
SU9516

> <ctcr_id>
7769

> <supplier_cmpd_id>
S7636

> <smiles>
COc1ccc2NC(=O)\C(=C/c3c[nH]cn3)c2c1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SU9516,377090-84-1,377090841,"377090 84 1","SU 9516",SU-9516,(Z)-3-((1H-imidazol-5-yl)methylene)-5-methoxyindolin-2-one,(Z)3((1Himidazol5yl)methylene)5methoxyindolin2one,"(Z) 3 ((1H imidazol 5 yl)met
hylene) 5 methoxyindolin 2 one",666837-93-0,666837930,66683,"EMD 572650",572650}

> <pdid>

> <targets>
{Apoptosis,Autophagy,CDK}

> <classes>
{Apoptosis,Autophagy,Cell Cycle/DNA Damage}

> <pubchem_cids>
{5289419}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 45  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8915    3.7585    0.0000 N   0  0
    3.8863    5.2585    0.0000 C   0  0
    5.1819    6.0161    0.0000 N   0  0
    5.1746    7.5169    0.0000 C   0  0
    3.8703    8.2580    0.0000 C   0  0
    3.8600    9.7580    0.0000 C   0  0
    5.1538   10.5169    0.0000 C   0  0
    6.4580    9.7759    0.0000 C   0  0
    6.4684    8.2760    0.0000 C   0  0
    7.7733    7.5346    0.0000 S   0  0
    7.7833    6.0346    0.0000 O   0  0
    9.0772    6.7930    0.0000 O   0  0
    9.0683    8.2932    0.0000 C   0  0
   10.3725    7.5523    0.0000 C   0  0
    9.0583    9.7932    0.0000 C   0  0
    2.5847    6.0040    0.0000 N   0  0
    1.2883    5.2495    0.0000 C   0  0
    1.2934    3.7495    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987   -1.5004    0.0000 N   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -6.4930   -3.7570    0.0000 N   0  0
   -7.7945   -3.0112    0.0000 C   0  0
   -9.0912   -3.7653    0.0000 C   0  0
   -9.0864   -5.2653    0.0000 N   0  0
  -10.3830   -6.0194    0.0000 C   0  0
   -7.7850   -6.0112    0.0000 C   0  0
   -6.4883   -5.2571    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 15 16  1  0
 16 17  2  0
 16 18  2  0
 16 19  1  0
 19 20  1  0
 19 21  1  0
  8 22  2  0
 22 23  1  0
 23 24  2  0
 24  6  1  0
  4 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28  3  1  0
 27 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 29  1  0
 32 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 39  1  0
 38 40  1  0
 40 41  1  0
 41 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
28829

> <plate>
Kinase v5-3

> <well>
C20

> <supplier_cmpd_name>
ASP3026

> <ctcr_id>
11906

> <supplier_cmpd_id>
S8054

> <smiles>
COc1c(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)ncn2)ccc(c1)N1CCC(CC1)N1CCN(C)CC1

> <pd_targets>
{ALK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase STKR family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family"}

> <pathway_reactome>
{}

> <broad_targets>
{ALK}

> <broad_moa>
{"ALK tyrosine kinase receptor inhibitor"}

> <synonyms>
{ASP3026,1097917-15-1,1097917151,ASP-3026,"ASP 3026",UNII-HP4L6MXF10,UNIIHP4L6MXF10,HP4L6MXF10,F6O,cc-325,cc325,MLS006011176,GTPL7740,SCHEMBL2827739,CHEMBL3545360,C29H40N8O3S,AOB6601,DTXSID90149038,EX
-A140,EXA140,QCR-144,QCR144,CHEBI:167650,HMS3673C17,BCP06436,2229AH,MFCD21609265,NSC765865,T1962}

> <pdid>
PD012874

> <targets>
{ALK}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{25134326}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  1  0            999 V2000
    2.9357   -7.1465    0.0000 C   0  0
    1.9988   -8.3179    0.0000 O   0  0
    2.3903   -5.7483    0.0000 C   0  0  2  0  0  0
    0.9074   -5.5222    0.0000 C   0  0
    3.3277   -4.5763    0.0000 O   0  0
    2.7822   -3.1780    0.0000 C   0  0
    3.7175   -2.0053    0.0000 C   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 N   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 O   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 C   0  0
    0.2015    3.2154    0.0000 C   0  0
    1.6774    3.4832    0.0000 C   0  0
    2.3882    2.1623    0.0000 N   0  0
    2.3285    4.8353    0.0000 C   0  0
    1.7136    6.1843    0.0000 N   0  0
    2.8318    7.1840    0.0000 N   0  0
    4.1282    6.4295    0.0000 C   0  0
    3.8112    4.9634    0.0000 N   0  0
    0.2472    6.4914    0.0000 C   0  0
   -0.2216    7.9163    0.0000 C   0  0
   -0.7528    5.3733    0.0000 C   0  0
    4.4186   -7.3727    0.0000 N   0  0
  1  2  2  0
  1  3  1  0
  3  4  1  6
  3  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15  9  1  0
 15 16  2  0
 16  6  1  0
 11 17  1  0
 17 18  2  0
 18 19  1  0
 19 10  2  0
 18 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 20  2  0
 21 25  1  0
 25 26  1  0
 25 27  1  0
  1 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28830

> <plate>
Kinase v5-3

> <well>
C22

> <supplier_cmpd_name>
GDC-0326

> <ctcr_id>
12217

> <supplier_cmpd_id>
S8157

> <smiles>
C(=O)([C@H](C)Oc1ccc2c3n(CCOc2c1)cc(n3)c1n(ncn1)C(C)C)N

> <pd_targets>
{PIK3CA}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by FGFR in disease","Signaling by FGFR1 in disease","FGFR1 mutant receptor activation","Signaling
 by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{DC032,GDC-0326,GDC0326,1282514-88-8,1282514888,CHEMBL3771364,"GDC 0326",SCHEMBL1485471,AMY16651,EX-A2543,EXA2543,BDBM50149548,s8157,CCG-268429,CCG268429,CS-7672,CS7672,AC-29899,AC29899,HY-101272,HY10
1272,J3.605.585E,Q27455759,T3985}

> <pdid>
PD063697

> <targets>
{PI3K,PI3K¦Á}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{58204997}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  1  0            999 V2000
   11.5921   -0.0044    0.0000 Cl  0  0
    6.4872   -5.2588    0.0000 C   0  0
    6.4921   -3.7588    0.0000 C   0  0  1  0  0  0
    7.7945   -3.0130    0.0000 C   0  0
    9.0913   -3.7668    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
    1.2990    3.7500    0.0000 C   0  0
    1.2990    5.2500    0.0000 O   0  0
    2.5981    3.0000    0.0000 C   0  0
    4.0238    3.4636    0.0000 S   0  0
    4.9055    2.2500    0.0000 C   0  0
    4.0238    1.0365    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
  3  2  1  6
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  9 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 13  1  0
 22 18  2  0
 14 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 12  1  0
 26 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28831

> <plate>
Kinase v5-3

> <well>
C04

> <supplier_cmpd_name>
OTS514 hydrochloride

> <ctcr_id>
12749

> <supplier_cmpd_id>
S7652

> <smiles>
Cl.C[C@@H](CN)c1ccc(cc1)c1c2c([nH]c(=O)c3sccc23)c(C)cc1O

> <pd_targets>
{NEK1,PBK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase NEK family","Other protein kinase TOPK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","NIMA (never in mitosis gene a)- related kinase (NEK) family","TOPK family"}

> <pathway_reactome>
{}

> <broad_targets>
{}

> <broad_moa>
{"TOPK inhibitor"}

> <synonyms>
{"OTS514 (hydrochloride)","OTS514 HCl","OTS514 hydrochloride","1338540-63-8 (free base)","1338540638 (free base)",CHEMBL4537262,SCHEMBL16908853,EX-A1932,EXA1932,"1338540-63-8(free base)","1338540638(f
ree base)",HY-18621A,HY18621A,s7652,CCG-268659,CCG268659,CS-0110966,CS0110966,T4134,"OTS514 hydrochloride(1338540-63-8(free base))"}

> <pdid>
PD057128

> <targets>
{TOPK}

> <classes>
{MAPK}

> <pubchem_cids>
{92044487}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.3408   -4.2142    0.0000 C   0  0
   -1.8408   -4.2089    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -6.4939    0.7411    0.0000 N   0  0
   -6.4894   -0.7597    0.0000 C   0  0
   -7.7846   -1.5163    0.0000 C   0  0
   -7.7770   -3.0163    0.0000 C   0  0
   -6.4742   -3.7597    0.0000 N   0  0
   -5.1790   -3.0032    0.0000 C   0  0
   -5.1866   -1.5032    0.0000 C   0  0
   -3.8967    0.7484    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11  9  1  0
  5 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 16 24  2  0
 24 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28832

> <plate>
Kinase v5-3

> <well>
C06

> <supplier_cmpd_name>
PIK-III

> <ctcr_id>
11500

> <supplier_cmpd_id>
S7683

> <smiles>
Nc1ncc(c(n1)CC1CC1)c1ccnc(Nc2ccncc2)n1

> <pd_targets>
{PIK3C3,PIK3CG,PIK3CD}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases","Phosphatidylinositol 3-kinase family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{"Signal Transduction",Metabolism,"Immune System","Signaling by Receptor Tyrosine Kinases","Metabolism of lipids","Cytokine Signaling in Immune system","Signaling by Insulin receptor","Phospholipid me
tabolism","Signaling by Interleukins","Insulin receptor signalling cascade","PI Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","IRS-mediated signalling","Synthesis of PIPs at the plasm
a membrane","Interleukin receptor SHC signaling","PI3K Cascade"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{IKII,PIK-III,PIKIII,1383716-40-2,1383716402,Vps34-PIK-III,Vps34PIKIII,CHEMBL3781415,"4'-(Cyclopropylmethyl)-N~2~-(Pyridin-4-Yl)-4,5'-Bipyrimidine-2,2'-Diamine","4'(Cyclopropylmethyl)N~2~(Pyridin4Yl)4
,5'Bipyrimidine2,2'Diamine","4'-(CYCLOPROPYLMETHYL)-N2-(PYRIDIN-4-YL)-(4,5'-BIPYRIMIDINE)-2,2'-DIAMINE","4'(CYCLOPROPYLMETHYL)N2(PYRIDIN4YL)(4,5'BIPYRIMIDINE)2,2'DIAMINE",VPS34-IN2,VPS34IN2,4ph4,Vps34
-PIK-III?,Vps34PIKIII?,GTPL9379,SCHEMBL,T6945}

> <pdid>
PD071608

> <targets>
{Autophagy,PI3K,PI3K¦Á,PI3K¦Â,PI3K¦Ã,PI3K¦Ä,Vps34}

> <classes>
{PI3K/Akt/mTOR signaling,Autophagy,PI3K/Akt/mTOR}

> <pubchem_cids>
{67983123}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  1  0            999 V2000
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 N   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 S   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -5.1047   -0.0031    0.0000 N   0  0
   -5.8532   -1.3040    0.0000 C   0  0  1  0  0  0
   -7.3533   -1.3093    0.0000 C   0  0  1  0  0  0
   -8.0987   -2.6109    0.0000 C   0  0
   -7.3442   -3.9074    0.0000 C   0  0
   -5.8442   -3.9021    0.0000 C   0  0
   -5.0987   -2.6005    0.0000 C   0  0
   -8.1078   -0.0129    0.0000 O   0  0
    5.1820   -6.0161    0.0000 C   0  0
    6.4849   -5.2728    0.0000 O   0  0
    5.1746   -7.5169    0.0000 N   0  0
    6.4695   -8.2740    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  3  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 11  1  0
 15 16  2  0
 16  8  1  0
 13 17  1  0
 18 17  1  6
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
 19 24  1  1
  1 25  1  0
 25 26  2  0
 25 27  1  0
 27 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28833

> <plate>
Kinase v5-3

> <well>
C08

> <supplier_cmpd_name>
BLZ945

> <ctcr_id>
13505

> <supplier_cmpd_id>
S7725

> <smiles>
c1(cc(ccn1)Oc1ccc2nc(sc2c1)N[C@H]1[C@@H](CCCC1)O)C(=O)NC

> <pd_targets>
{CSF1R,PDGFRB,KIT}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction",Disease,"RNA Polymerase II Transcription","Intracellular signaling by second messengers","Diseases of signal transduction by growth factor rece
ptors and second messengers","Generic Transcription Pathway","PIP3 activates AKT signaling","Signaling by KIT in disease","Transcriptional Regulation by VENTX","Negative regulation of the PI3K/AKT net
work","Drug resistance of KIT mutants",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Dasatinib-resistant KIT mutants"}

> <broad_targets>
{}

> <broad_moa>
{"CSF1R inhibitor"}

> <synonyms>
{BLZ945,953769-46-5,953769465,BLZ-945,UNII-7W3V82OQ0P,UNII7W3V82OQ0P,7W3V82OQ0P,CHEMBL4227505,C20H22N4O3S,"BLZ 945",MIDODRINEHYDROCHLORIDE,GTPL8250,SCHEMBL2676695,EX-A817,EXA817,SYN1197,3193AH,BDBM504
60035,MFCD28142668,NSC758006,s7725,ZINC68203100,AKOS025396391,CCG-268639,CCG268639,CS-3971,CS3971,T6119}

> <pdid>
PD017171

> <targets>
{CSF-1R}

> <classes>
{"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{46184986}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -6.5002    3.7446    0.0000 C   0  0
   -7.7969    2.9905    0.0000 C   0  0
   -9.0983    3.7364    0.0000 C   0  0
   -9.1031    5.2364    0.0000 C   0  0
   -7.8065    5.9905    0.0000 C   0  0
   -6.5050    5.2446    0.0000 C   0  0
   -5.2093    6.0019    0.0000 O   0  0
   -3.9058    5.2596    0.0000 C   0  0
  -10.4037    5.9854    0.0000 N   0  0
  -10.4063    7.4862    0.0000 C   0  0
   -9.1071    8.2359    0.0000 N   0  0
   -9.1066    9.7359    0.0000 C   0  0
   -7.8051   10.4833    0.0000 N   0  0
   -6.5067    9.7307    0.0000 C   0  0
   -5.2047   10.4757    0.0000 C   0  0
   -3.9085    9.7209    0.0000 C   0  0
   -3.9141    8.2209    0.0000 O   0  0
   -5.2160    7.4758    0.0000 C   0  0
   -6.5122    8.2306    0.0000 C   0  0
  -10.4055   10.4863    0.0000 C   0  0
  -10.4081   11.9871    0.0000 C   0  0
  -11.7080   12.7356    0.0000 C   0  0
  -11.7047    9.7366    0.0000 N   0  0
  -11.7051    8.2366    0.0000 C   0  0
  -13.0067    7.4893    0.0000 C   0  0
  -13.0098    5.9893    0.0000 N   0  0
  -14.3044    8.2416    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 17 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 27  1  0
 25 33  2  0
 33 34  1  0
 34 35  1  0
 33 36  1  0
 36 37  2  0
 37 23  1  0
 37 38  1  0
 38 39  1  0
 38 40  2  0
M  END
> <name>
UTKinase_V5

> <id>
28834

> <plate>
Kinase v5-3

> <well>
C10

> <supplier_cmpd_name>
Gilteritinib (ASP2215)

> <ctcr_id>
12388

> <supplier_cmpd_id>
S7754

> <smiles>
CN1CCN(CC1)C2CCN(CC2)c3ccc(cc3OC)Nc5nc(NC4CCOCC4)c(CC)nc5C(N)=O

> <pd_targets>
{MERTK,LTK,ALK,AXL,RET,NTRK1,FLT3,ROS1,REP,ETV6,EML4,HTR1A,HTR1B,HTR1D,HTR1E,HTR1F,HTR2A,HTR2B,HTR2C,HTR3A,HTR3B,HTR3C,HTR3D,HTR3E,HTR4,HTR6,HTR7}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Tyrosine protein kinase Axl family","Tyrosine protein kinase Alk family","TKL protein kinase STKR fami
ly","Tyrosine protein kinase Ret family","Tyrosine protein kinase Trk family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Sev family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Other protein targets","Catalytic receptors","Anti-infective targets","Receptor kinases","Viral protein targets","TK: Tyrosine kinase","Coronavirus (CoV) proteins","Receptor tyrosine kinas
es (RTKs)","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XIV RTKs: RET","Type VII RTKs: Neurotrophin receptor/Tr
k family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XVII RTKs: ROS receptors"}

> <pathway_reactome>
{Hemostasis,"Signal Transduction","Developmental Biology",Disease,"Cell surface interactions at the vascular wall","Signaling by Receptor Tyrosine Kinases","Nervous system development","Infectious dis
ease","Signaling by VEGF","Axon guidance","Signaling by NTRKs","Signaling by Insulin receptor","SARS-CoV Infections","VEGFA-VEGFR2 Pathway","RET signaling","Signaling by NTRK1 (TRKA)","Insulin recepto
r signalling cascade","SARS-CoV-2 Infection","Signalling to ERKs","IRS-mediated signalling","SARS-CoV-2 Genome Replication and Transcription","Prolonged ERK activation events","PI3K Cascade","Replicat
ion of the SARS-CoV-2 genome","ARMS-mediated activation"}

> <broad_targets>
{FLT3}

> <broad_moa>
{"FLT3 inhibitor"}

> <synonyms>
{Gilteritinib,1254053-43-4,1254053434,ASP2215,ASP-2215,Xospata,UNII-66D92MGC8M,UNII66D92MGC8M,"ASP 2215",66D92MGC8M,"Gilteritinib HCl","1254053-43-4 (free base)","1254053434 (free base)","Gilteritinib
 (USAN:INN)","Gilteritinib (ASP2215)",gilteritinibum,C6F,Gilteritinib(ASP2215),"Gilteritinib (",T4409}

> <pdid>
PD050507

> <targets>
{FLT3,"TAM Receptor",AXL}

> <classes>
{"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{49803313}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
   11.9152    5.0440    0.0000 N   0  0
   11.0702    3.8046    0.0000 C   0  0
   11.7211    2.4532    0.0000 C   0  0
   10.8761    1.2138    0.0000 C   0  0
    9.3803    1.3259    0.0000 C   0  0
    8.7295    2.6773    0.0000 C   0  0
    9.5744    3.9167    0.0000 C   0  0
    7.2328    2.7895    0.0000 S   0  0
    6.5824    4.1411    0.0000 O   0  0
    8.0780    4.0287    0.0000 O   0  0
    6.3855    1.5484    0.0000 N   0  0
    7.1347    0.2489    0.0000 C   0  0
    6.5858   -1.1471    0.0000 C   0  0
    5.1522   -1.5883    0.0000 C   0  0
    3.8990   -0.7508    0.0000 N   0  0
    3.8022    0.7533    0.0000 C   0  0
    4.9024    1.7729    0.0000 C   0  0
    2.5988   -1.5004    0.0000 S   0  0
    2.5983   -3.0004    0.0000 O   0  0
    3.8975   -2.2510    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  6  8  1  0
  8  9  2  0
  8 10  2  0
  8 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 11  1  0
 15 18  1  0
 18 19  2  0
 18 20  2  0
 18 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 29 30  2  0
 30 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28837

> <plate>
Kinase v5-3

> <well>
C16

> <supplier_cmpd_name>
DASA-58

> <ctcr_id>
8257

> <supplier_cmpd_id>
S7928

> <smiles>
Nc1cccc(c1)S(=O)(=O)N2CCCN(CC2)S(=O)(=O)c3ccc4OCCOc4c3

> <pd_targets>
{PKM}

> <pathway_gtopdb>
{Enzyme}

> <pathway_chembl>
{Enzymes,"2.7.1.40 Pyruvate kinases"}

> <pathway_reactome>
{Metabolism,"Metabolism of carbohydrates","Glucose metabolism",Glycolysis}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ASA5,DASA-58,DASA58,1203494-49-8,1203494498,CHEMBL1089334,ML203,SCHEMBL12354635,CHEBI:93419,GTPL10556,HMS3873J13,BCP16322,EX-A2300,EXA2300,BDBM50361557,ML-203,s7928,ZINC36382543,CCG-269271,CCG269271,
"compound 1 (PMID: 21958545)",CS-5257,CS5257,NCGC00185916-01,NCGC0018591601,NCGC00185916-06,NCGC0018591606,AC-32925,AC32925,AK5,T6816,13941}

> <pdid>
PD003316

> <targets>
{PKM,"Pyruvate Kinase"}

> <classes>
{Metabolic Enzyme/Protease}

> <pubchem_cids>
{44543605}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 39  0  0  1  0            999 V2000
    2.5818   -6.0055    0.0000 C   0  0
    1.2859   -5.2502    0.0000 C   0  0
   -0.0160   -5.9953    0.0000 O   0  0
    1.2925   -3.7494    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1937   -3.0093    0.0000 O   0  0
    3.8912   -5.2578    0.0000 N   0  0
    5.1894   -6.0109    0.0000 C   0  0  2  0  0  0
    6.4889   -5.2601    0.0000 C   0  0
    6.4894   -3.7592    0.0000 C   0  0
    7.7889   -3.0084    0.0000 C   0  0
    7.7894   -1.5076    0.0000 N   0  0
    9.0889   -0.7568    0.0000 C   0  0
    9.0894    0.7432    0.0000 N   0  0
   10.3879   -1.5068    0.0000 N   0  0
    5.1873   -7.5117    0.0000 C   0  0
    3.8869   -8.2595    0.0000 O   0  0
    6.4855   -8.2648    0.0000 N   0  0
    6.4833   -9.7656    0.0000 C   0  0  2  0  0  0
    7.7815  -10.5187    0.0000 C   0  0
    7.7794  -12.0195    0.0000 C   0  0
    9.0758  -12.7741    0.0000 C   0  0
    9.0706  -14.2741    0.0000 C   0  0
    7.7690  -15.0196    0.0000 C   0  0
    6.4726  -14.2651    0.0000 C   0  0
    6.4778  -12.7651    0.0000 C   0  0
    5.1838  -10.5165    0.0000 C   0  0
    5.1833  -12.0165    0.0000 O   0  0
    3.8848   -9.7665    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  5  4  1  6
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13  7  1  0
  5 14  1  0
 14 15  2  0
 14 16  1  0
 17 16  1  6
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 22 24  1  0
 17 25  1  0
 25 26  2  0
 25 27  1  0
 28 27  1  6
 28 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
 28 36  1  0
 36 37  2  0
 36 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28839

> <plate>
Kinase v5-3

> <well>
F08

> <supplier_cmpd_name>
DTP3

> <ctcr_id>
15818

> <supplier_cmpd_id>
S7637

> <smiles>
CC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HY-100538,DTP3,DTP3}

> <pdid>
PD021585

> <targets>
{JNK,"DNA/RNA Synthesis",JAK}

> <classes>
{Cell Cycle/DNA Damage,Epigenetics,JAK/STAT Signaling,Stem Cell/Wnt}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 39  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -7.7907   -1.5158    0.0000 N   0  0
   -9.0920   -0.7681    0.0000 C   0  0
   -9.0945    0.7319    0.0000 O   0  0
  -10.3907   -1.5203    0.0000 N   0  0
  -11.6919   -0.7725    0.0000 C   0  0
  -12.9910   -1.5225    0.0000 C   0  0
  -14.2901   -0.7725    0.0000 C   0  0
  -14.2901    0.7275    0.0000 C   0  0
  -15.5883    1.4806    0.0000 O   0  0
  -15.5861    2.9815    0.0000 C   0  0
  -16.8826    3.7360    0.0000 N   0  0
  -16.8774    5.2360    0.0000 C   0  0
  -18.1738    5.9905    0.0000 N   0  0
  -15.5758    5.9815    0.0000 N   0  0
  -14.2793    5.2270    0.0000 C   0  0
  -14.2845    3.7271    0.0000 C   0  0
  -12.9910    1.4775    0.0000 C   0  0
  -11.6920    0.7275    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -5.2060    2.9917    0.0000 C   0  0
   -6.5071    3.7380    0.0000 F   0  0
   -3.9093    3.7458    0.0000 F   0  0
   -5.2105    4.4917    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  1  0
 20 21  2  3
 21 22  1  0
 22 23  1  0
 22 24  2  3
 24 25  1  0
 25 26  2  3
 26 20  1  0
 18 27  1  0
 27 28  2  3
 28 15  1  0
 10 29  1  0
 29 30  2  3
 30  7  1  0
 30 31  1  0
 31 32  1  0
 31 33  1  0
 31 34  1  0
  5 35  1  0
 35 36  1  0
 36  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28840

> <plate>
Kinase v5-3

> <well>
E20

> <supplier_cmpd_name>
K03861

> <ctcr_id>
12271

> <supplier_cmpd_id>
S8100

> <smiles>
CN1CCN(CC2=CC=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2C(F)(F)F)CC1

> <pd_targets>
{CDK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK1 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional Regulation by TP53","Regulation of TP53 Activity","Regulation of TP53 Expression a
nd Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{853299-07-7,853299077,K03861,"AUZ 454",AUZ454,SCHEMBL3676641,CHEMBL4472486,BDBM154576,BCP24150,EX-A1910,EXA1910,s8100,ZINC139929867,CCG-269702,CCG269702,CS-5822,CS5822,BS-18180,BS18180,HY-15004,HY150
04,"K 03861;K-03861","K 03861;K03861",K-03861,Q27462668,"K03861 (1)",LQ5,T6866}

> <pdid>
PD071534

> <targets>
{CDK,CDK2(A144C),CDK2(C118L),CDK2(C118L/A144C),CDK2(WT)}

> <classes>
{"Cell Cycle/Checkpoint"}

> <pubchem_cids>
{11260561}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 32  0  0  0  0            999 V2000
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 N   0  0
    6.4924   -3.7566    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 N   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 O   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -0.3115    2.9665    0.0000 N   0  0
    0.5701    4.1788    0.0000 C   0  0
   -0.0400    5.5491    0.0000 C   0  0
   -1.5318    5.7059    0.0000 O   0  0
   -2.4135    4.4923    0.0000 C   0  0
   -3.2660    3.2582    0.0000 C   0  0
   -2.9916    5.8765    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  2  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 12 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
 11 20  1  0
 20 21  2  0
 21 22  1  0
 22 10  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 26 27  1  0
 26 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28841

> <plate>
Kinase v5-3

> <well>
E22

> <supplier_cmpd_name>
GDC-0084

> <ctcr_id>
12219

> <supplier_cmpd_id>
S8163

> <smiles>
c1c(cnc(n1)N)c1nc2c(c(n1)N1CCOCC1)nc1n2CCOC1(C)C

> <pd_targets>
{PIK3CA,MTOR,PIK3CB,PIK3CD,PIK3CG,PIK3R1,PIK3R2,PIK3R3,PIK3R5}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfami
ly"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Signaling by FGFR in disease","Generic 
Transcription Pathway","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Signaling by cytosolic FGFR1 fusion mutant
s","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
{}

> <broad_moa>
{"mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{DC008,GDC-0084,GDC0084,1382979-44-3,1382979443,paxalisib,UNII-P5DKZ70636,UNIIP5DKZ70636,CHEMBL3813842,P5DKZ70636,G02441729,"Paxalisib (USAN)","Paxalisib (USAN/INN)",SCHEMBL10239943,GTPL10097,BCP18386
,EX-A1019,EXA1019,"GDC 0084",GDC-0084RG7666,GDC0084RG7666,BDBM50177662,MFCD30187522,NSC792987,s8163,T3705}

> <pdid>
PD078344

> <targets>
{PI3K,mTOR,PI3K¦Á,PI3K¦Â,PI3K¦Ã,PI3K¦Ä}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{57384863}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 39  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -3.9021   -3.7405    0.0000 C   0  0
   -5.2008   -2.9882    0.0000 N   0  0
   -6.5020   -3.7360    0.0000 C   0  0
   -7.8012   -2.9861    0.0000 C   0  0
   -7.8043   -1.4852    0.0000 O   0  0
   -9.1044   -0.7372    0.0000 C   0  0
   -9.1002   -3.7361    0.0000 C   0  0
   -9.1002   -5.2361    0.0000 C   0  0
   -7.8011   -5.9861    0.0000 C   0  0
   -6.5021   -5.2361    0.0000 C   0  0
  -10.3999   -5.9865    0.0000 N   0  0
  -11.7002   -5.2386    0.0000 C   0  0
  -12.9980   -5.9907    0.0000 C   0  0
  -12.9956   -7.4907    0.0000 O   0  0
  -11.6954   -8.2386    0.0000 C   0  0
  -10.3976   -7.4865    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 N   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0120   -6.0044    0.0000 C   0  0
   -0.0163   -7.5043    0.0000 F   0  0
    1.2894   -5.2585    0.0000 F   0  0
    1.2847   -6.7583    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 17 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 16  1  0
 21 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
 14 30  2  0
 30 31  1  0
 31 32  2  0
 32 12  1  0
 32 33  1  0
 33 34  1  0
 33 35  1  0
 33 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28842

> <plate>
Kinase v5-3

> <well>
E04

> <supplier_cmpd_name>
PND-1186 (VS-4718)

> <ctcr_id>
11951

> <supplier_cmpd_id>
S7653

> <smiles>
CNC(=O)c1ccccc1Nc1cc(Nc2c(OC)cc(cc2)N2CCOCC2)ncc1C(F)(F)F

> <pd_targets>
{PTK2,MAPK10,MAPK9}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","Tyrosine protein kinase Fak family","CMGC protein kinase MAPK family","CMGC protein kinase JNK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases
)","Non-receptor tyrosine kinases (nRTKs)","JNK subfamily","Fak family"}

> <pathway_reactome>
{Disease,"Immune System","Infectious disease","Innate Immune System","Leishmania infection","Toll-like Receptor Cascades","Parasite infection","Toll Like Receptor 5 (TLR5) Cascade","Leishmania phagocy
tosis","MyD88 cascade initiated on plasma membrane","FCGR3A-mediated phagocytosis","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of tran
scription factors"}

> <broad_targets>
{}

> <broad_moa>
{"focal adhesion kinase inhibitor"}

> <synonyms>
{ND118,PND-1186,PND1186,1061353-68-1,1061353681,VS-4718,VS4718,"PND 1186",SR2516,UNII-L2BD0MW4OL,UNIIL2BD0MW4OL,L2BD0MW4OL,"PND-1186 (VS-4718)","PND1186 (VS4718)",CHEMBL2430358,SR-2156,SR2156,"SR 2516
",SR-2516,"VS 4718",SCHEMBL47360,GTPL8742,CHEMBL3040440,AOB6018,EX-A505,EXA505,C25H26F3N5O3,HMS3673G09,BCP10711,2664AH,T1950}

> <pdid>
PD003237

> <targets>
{FAK,Apoptosis}

> <classes>
{Angiogenesis,Cytoskeletal Signaling,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{25073775}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
    7.5955   -3.5619    0.0000 C   0  0
    6.5954   -4.6799    0.0000 C   0  0
    5.1272   -4.3728    0.0000 C   0  0
    4.6589   -2.9478    0.0000 C   0  0
    5.6590   -1.8298    0.0000 C   0  0
    7.1272   -2.1368    0.0000 N   0  0
    3.1905   -2.6376    0.0000 C   0  0
    2.7248   -1.2135    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 Cl  0  0
    2.7248    1.2135    0.0000 N   0  0
    3.6065    0.0000    0.0000 C   0  0
    9.0651   -3.8660    0.0000 N   0  0
   10.0641   -2.7460    0.0000 C   0  0
   11.5338   -3.0502    0.0000 C   0  0
   12.5339   -1.9322    0.0000 C   0  0
   14.0021   -2.2392    0.0000 N   0  0
   14.4704   -3.6642    0.0000 C   0  0
   13.4704   -4.7823    0.0000 C   0  0
   12.0021   -4.4753    0.0000 C   0  0
   15.9394   -3.9714    0.0000 C   0  0
   16.9401   -2.8540    0.0000 F   0  0
   16.4072   -5.3966    0.0000 F   0  0
   17.4075   -4.2791    0.0000 F   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  4  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 13 15  1  0
 10 16  1  0
 16 17  1  0
 17  8  2  0
  1 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 23 26  1  0
 26 27  1  0
 26 28  1  0
 26 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28846

> <plate>
Kinase v5-3

> <well>
E12

> <supplier_cmpd_name>
Pexidartinib (PLX3397)

> <ctcr_id>
11948

> <supplier_cmpd_id>
S7818

> <smiles>
c1(ccc(cn1)Cc1c2c(ncc(c2)Cl)[nH]c1)NCc1cnc(cc1)C(F)(F)F

> <pd_targets>
{KDR,CSF1R,KIT,FLT3,NTRK3,LCK,FLT1,CDK19,PDGFRB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Trk family"
,"Tyrosine protein kinase Src family","CMGC protein kinase CDK family","CMGC protein kinase CDK8 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","Recepto
r tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","CDK8 subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 rece
ptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Src family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Disease,Metabolism,"Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor
 receptors and second messengers","Infectious disease","Metabolism of lipids","Intracellular signaling by second messengers","Signaling by VEGF","Generic Transcription Pathway","Signaling by KIT in di
sease","Signaling by Insulin receptor","Signaling by NTRKs","HIV Infection","Regulation of lipid metabolism by PPARalpha","PIP3 activates AKT signaling","VEGFA-VEGFR2 Pathway","Transcriptional Regulat
ion by VENTX","Drug resistance of KIT mutants","Insulin receptor signalling cascade","Signaling by NTRK3 (TRKC)","Host Interactions of HIV factors","VEGF ligand-receptor interactions","PPARA activates
 gene expression","Negative regulation of the PI3K/AKT network","VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","IRS-mediated signalling","Activated NTRK3 signals through PI3K",
"The role of Nef in HIV-1 replication and disease pathogenesis","VEGF binds to VEGFR leading to receptor dimerization",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","PI3K Cascade","Nef-mediates dow
n modulation of cell surface receptors by recruiting them to clathrin adapters","Nef Mediated CD4 Down-regulation"}

> <broad_targets>
{CSF1R,FLT3,KIT}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{NSC800843,s7818,Pexidartinib,1029044-16-3,1029044163,"Pexidartinib (PLX3397)",PLX3397,PLX-3397,Turalio,UNII-6783M2LV5X,UNII6783M2LV5X,CML-261,CML261,CHEMBL3813873,6783M2LV5X,"1029044-16-3 (free base)
","1029044163 (free base)","Pexidartinib (INN)",pexidartinibum,"Pexidartinib (USAN)",Pexidartinib(PLX,T2115}

> <pdid>
PD012397

> <targets>
{CSF-1R,c-Kit,Kit,FLT3}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{25151352}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  1  0            999 V2000
    6.4902   -5.2570    0.0000 C   0  0
    6.4931   -3.7570    0.0000 C   0  0
    7.7906   -4.5097    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 N   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -2.5981   -3.0008    0.0000 C   0  0  2  0  0  0
   -1.3002   -3.7529    0.0000 C   0  0
   -1.3026   -5.2529    0.0000 C   0  0
   -2.6028   -6.0009    0.0000 C   0  0  2  0  0  0
   -3.9007   -5.2488    0.0000 C   0  0
   -3.8983   -3.7488    0.0000 C   0  0
   -2.6021   -7.5017    0.0000 O   0  0
   -1.3032   -8.2519    0.0000 C   0  0
    7.7938   -3.0099    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  7 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 13  1  0
 21 16  1  6
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 21  1  0
 24 27  1  1
 27 28  1  0
  2 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28847

> <plate>
Kinase v5-3

> <well>
E14

> <supplier_cmpd_name>
CC-223

> <ctcr_id>
11619

> <supplier_cmpd_id>
S7886

> <smiles>
CC(C)(c1ncc(cc1)c1cnc2c(n1)N(C(=O)CN2)[C@@H]1CC[C@H](CC1)OC)O

> <pd_targets>
{CSF1R,FLT4,MTOR,PIK3CA,PIK3C3,PIK3CB,PIK3CD,PI4KB,KCNH2,PIK3CG,MLST8,RPTOR}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,Transferase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","TK protein kinase group","Atypical protein kinase group","Voltage-gated potassium channel","
Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Kinases (EC 2.7.x.x)","Voltage-gated ion channels","Receptor kinases",Atypical,"Lipid modifying kinases","Potassium channels","TK: Tyrosine kin
ase","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidylinositol 3-kinase family","1-phosphatidylinositol 4-kinase fam
ily","Voltage-gated potassium channels","Receptor tyrosine kinases (RTKs)","FRAP subfamily","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth fact
or) receptor family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction",Disease,"Immune System",Metabolism,"Muscle contraction","RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Diseases of
 signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Immune system","Metabolism of lipids","Cardiac conduction","Generic Transcription Pathway","Signaling by V
EGF","Signaling by FGFR in disease","Signaling by Insulin receptor","Signaling by Interleukins","Phospholipid metabolism","Phase 3 - rapid repolarisation","Transcriptional Regulation by VENTX","VEGF l
igand-receptor interactions","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","Insulin receptor signalling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","PI Metabolis
m","VEGF binds to VEGFR leading to receptor dimerization","Regulation of TP53 Activity","FGFR1 mutant receptor activation","IRS-mediated signalling","Interleukin receptor SHC signaling","Synthesis of 
PIPs at the Golgi membrane","Synthesis of PIPs at the plasma membrane","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","Regulation of TP53 
Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor"}

> <synonyms>
{C22,cc-223,cc223,1228013-30-6,1228013306,Onatasertib,UNII-I8RA3543SY,UNIII8RA3543SY,I8RA3543SY,CHEMBL3586404,ATG-008,ATG008,"Onatasertib (USAN)",CC223,"compound 37 (PMID: 26083478)","onatasertib (pro
posed INN)",SCHEMBL138069,SCHEMBL153700,SCHEMBL800493,GTPL8914,SCHEMBL16272828,EX-A781,EXA781,BCP09,T3351,CC-223}

> <pdid>
PD051630

> <targets>
{mTOR,c-Fms,DNA-PK,FLT4,PI3K-¦Á,Apoptosis}

> <classes>
{DNA Damage/DNA Repair,Angiogenesis,PI3K/Akt/mTOR signaling,Tyrosine Kinase/Adaptors,Apoptosis,PI3K/Akt/mTOR}

> <pubchem_cids>
{58298316}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    3.9200   -5.8774    0.0000 C   0  0
    4.8054   -4.6666    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4983    0.7413    0.0000 O   0  0
    6.4458   -1.8433    0.0000 C   0  0
    7.4106   -2.9853    0.0000 C   0  0
    8.8868   -2.7191    0.0000 N   0  0
    9.3943   -1.3075    0.0000 C   0  0
    8.4256   -0.1623    0.0000 C   0  0
    6.9494   -0.4285    0.0000 N   0  0
    8.9334    1.2500    0.0000 C   0  0
   10.3656    1.6508    0.0000 N   0  0
   10.4097    3.1502    0.0000 N   0  0
    8.9974    3.6554    0.0000 C   0  0
    8.0804    2.4683    0.0000 O   0  0
    8.5765    5.0933    0.0000 C   0  0
    9.6118    6.1787    0.0000 C   0  0
    7.1189    5.4477    0.0000 C   0  0
    8.1544    6.5327    0.0000 C   0  0
   10.8705   -1.0413    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  3  1  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
  4 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 25  1  0
 28 30  1  0
 30 31  1  0
 30 32  1  0
 30 33  1  0
 22 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28849

> <plate>
Kinase v5-3

> <well>
E18

> <supplier_cmpd_name>
AZD8835

> <ctcr_id>
12238

> <supplier_cmpd_id>
S7966

> <smiles>
CCn1c(nc(n1)C1CCN(CC1)C(=O)CCO)c1cnc(c(n1)c1nnc(o1)C(C)(C)C)N

> <pd_targets>
{PIK3CB,PIK3CA,PIK3CG,PIK3CD}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{"Signal Transduction",Disease,Metabolism,"Immune System","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lip
ids","Cytokine Signaling in Immune system","Signaling by Insulin receptor","Signaling by FGFR in disease","Phospholipid metabolism","Signaling by Interleukins","Insulin receptor signalling cascade","S
ignaling by FGFR1 in disease","PI Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","IRS-mediated signalling","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membrane"
,"Interleukin receptor SHC signaling","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
{PIK3CA,PIK3CD}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{AZD8835,AZD-8835,1620576-64-8,1620576648,"AZD 8835",UNII-8B97A88D35,UNII8B97A88D35,8B97A88D35,"compound 25 (PMID: 26475521)",GTPL8915,CHEMBL3894518,SCHEMBL15877923,"AZD 8835 (WHO-DD)","AZD 8835 (WHOD
D)",BDBM185362,BCP20347,EX-A2295,EXA2295,NSC786099,s7966,ZINC145460849,CCG-269444,CCG269444,CS-4984,CS4984,NSC-786099,T6774}

> <pdid>
PD012802

> <targets>
{PI3K,PI3K¦Á,PI3K¦Â,PI3K¦Ã,PI3K¦Ä}

> <classes>
{PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR}

> <pubchem_cids>
{76685059}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 45  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -2.6012   -3.0008    0.0000 O   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -2.6108   -6.0039    0.0000 F   0  0
   -7.8061   -5.9891    0.0000 N   0  0
   -7.8092   -7.4899    0.0000 C   0  0
   -6.5114   -8.2421    0.0000 O   0  0
   -9.1099   -8.2385    0.0000 C   0  0
  -10.4592   -7.6128    0.0000 N   0  0
  -11.4667   -8.7240    0.0000 N   0  0
  -10.7212  -10.0257    0.0000 C   0  0
   -9.2529   -9.7188    0.0000 C   0  0
   -8.1374  -10.7189    0.0000 O   0  0
   -8.4453  -12.1878    0.0000 C   0  0
   -7.3284  -13.1891    0.0000 C   0  0
  -12.9587   -8.5620    0.0000 C   0  0
  -13.7478   -9.8397    0.0000 C   0  0
  -15.2470   -9.7904    0.0000 C   0  0
  -15.9540   -8.4675    0.0000 C   0  0
  -15.1617   -7.1938    0.0000 C   0  0
  -13.6625   -7.2430    0.0000 C   0  0
  -12.8699   -5.9696    0.0000 C   0  0
  -17.4532   -8.4182    0.0000 F   0  0
    2.5972    1.5031    0.0000 O   0  0
    2.5951    3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    2.5951   -3.0031    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  4  1  0
  7 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 17 18  1  0
 15 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 22  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 24 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
 35 36  1  0
 33 37  1  0
  2 38  1  0
 38 39  1  0
  1 40  1  0
 40 41  1  0
M  END
> <name>
UTKinase_V5

> <id>
28850

> <plate>
Kinase v5-3

> <well>
H08

> <supplier_cmpd_name>
LDC1267

> <ctcr_id>
12811

> <supplier_cmpd_id>
S7638

> <smiles>
c1(c(cc2c(c1)c(ccn2)Oc1ccc(cc1F)NC(=O)c1nn(cc1OCC)c1ccc(cc1C)F)OC)OC

> <pd_targets>
{TYRO3,MERTK,AXL}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Axl family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{Hemostasis,"Signal Transduction","Cell surface interactions at the vascular wall","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","VEGFA-VEGFR2 Pathway"}

> <broad_targets>
{AXL,MERTK,TYRO3}

> <broad_moa>
{"protein tyrosine kinase inhibitor"}

> <synonyms>
{LDC1267,1361030-48-9,1361030489,LDC-1267,CHEMBL3808844,SCHEMBL167963,GTPL8247,AOB87188,BCP14023,EX-A2265,EXA2265,BDBM50172075,s7638,AKOS026750422,ZINC113241878,CCG-270046,CCG270046,CS-3603,CS3603,SB1
9391,NCGC00386431-02,NCGC0038643102,AC-31422,AC31422,AK317101,AS-55927,AS55927,HY-12494,HY12494,A13003,Q27079711,R6H,T2311}

> <pdid>
PD012843

> <targets>
{"TAM Receptor",AXL,Mer,Tyro3}

> <classes>
{"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{56847486}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  1  0            999 V2000
    9.8089    4.5189    0.0000 C   0  0
    8.4855    3.8128    0.0000 C   0  0
    7.1614    3.1063    0.0000 C   0  0
    5.8372    2.3998    0.0000 C   0  0
    5.7875    0.9007    0.0000 O   0  0
    4.5650    3.1911    0.0000 N   0  0
    4.4475    4.6865    0.0000 C   0  0
    2.9890    5.0368    0.0000 C   0  0
    2.2051    3.7579    0.0000 C   0  0
    3.1884    2.6409    0.0000 C   0  0  1  0  0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 N   0  0
    2.7248   -1.2135    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    3.1884   -2.6409    0.0000 C   0  0
    4.6235   -3.0601    0.0000 C   0  0
    4.9782   -4.5176    0.0000 C   0  0
    3.8933   -5.5535    0.0000 C   0  0
    2.4538   -5.1320    0.0000 C   0  0
    2.0991   -3.6745    0.0000 C   0  0
    4.2452   -7.0125    0.0000 C   0  0
    5.6840   -7.4366    0.0000 O   0  0
    3.1583   -8.0475    0.0000 N   0  0
    3.5102   -9.5064    0.0000 C   0  0
    2.4254  -10.5424    0.0000 C   0  0
    2.7801  -11.9999    0.0000 C   0  0
    4.2196  -12.4215    0.0000 C   0  0
    5.3045  -11.3856    0.0000 C   0  0
    4.9498   -9.9281    0.0000 N   0  0
  1  2  1  0
  2  3  3  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10  6  1  0
 10 11  1  6
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 11  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 13 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 24 27  1  0
 27 28  2  0
 27 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28851

> <plate>
Kinase v5-3

> <well>
G20

> <supplier_cmpd_name>
Acalabrutinib (ACP-196)

> <ctcr_id>
11339

> <supplier_cmpd_id>
S8116

> <smiles>
CC#CC(=O)N1CCC[C@H]1c1nc(c2n1ccnc2N)c1ccc(cc1)C(=O)Nc1ccccn1

> <pd_targets>
{FYN,TEC,JAK3,LYN,ERBB2,BMX,BTK,ITK,TXK,ERBB4,EGFR,SRC,LCK,BLK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase Tec family","Tyrosine protein kinase JakA family","Tyrosine protein kinase EGFR 
family","Tyrosine protein kinase SrcA"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Src family","Tec family","Janus kinase (JakA) fami
ly","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{Disease,"Immune System","Developmental Biology",Metabolism,"Neuronal System","Signal Transduction","Gene expression (Transcription)","Infectious disease","Cytokine Signaling in Immune system","Nervou
s system development","Metabolism of lipids","Adaptive Immune System","Innate Immune System","Transmission across Chemical Synapses","Signaling by GPCR","Signaling by Receptor Tyrosine Kinases","RNA P
olymerase II Transcription","HIV Infection","Signaling by Interleukins","Leishmania infection","Axon guidance","Phospholipid metabolism","TCR signaling","Fc epsilon receptor (FCERI) signaling","Neurot
ransmitter receptors and postsynaptic signal transmission","GPCR downstream signalling","Signaling by NTRKs","Generic Transcription Pathway","Host Interactions of HIV factors",Interleukin-3,"Interleuk
in-5 and GM-CSF signaling","Interleukin-2 family signaling","Leishmania parasite growth and survival","Semaphorin interactions","PI Metabolism","Parasite infection","Generation of second messenger mol
ecules","FCERI mediated Ca+2 mobilization","Activation of NMDA receptors and postsynaptic events","G alpha (q) signalling events","Signaling by NTRK1 (TRKA)","Transcriptional regulation by RUNX1","The
 role of Nef in HIV-1 replication and disease pathogenesis","Interleukin-15 signaling","Anti-inflammatory response favouring Leishmania parasite infection","Sema4D in semaphorin signaling","Synthesis 
of PIPs at the plasma membrane","Leishmania phagocytosis","Post NMDA receptor activation events","Gastrin-CREB signalling pathway via PKC and MAPK","Signalling to ERKs","RUNX1 regulates transcription 
of genes involved in BCR signaling","Nef and signal transduction","FCGR3A-mediated IL10 synthesis","Sema4D induced cell migration and growth-cone collapse","FCGR3A-mediated phagocytosis","Long-term po
tentiation","EGFR Transactivation by Gastrin","Signalling to RAS","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","p38MAPK events","Nef Mediated CD4 Do
wn-regulation"}

> <broad_targets>
{BTK}

> <broad_moa>
{"Bruton's tyrosine kinase (BTK) inhibitor"}

> <synonyms>
{Acalabrutinib,1420477-60-6,1420477606,ACP-196,ACP196,Calquence,"Acalabrutinib (ACP-196)","Acalabrutinib (ACP196)",UNII-I42748ELQW,UNIII42748ELQW,I42748ELQW,Acalabrutinib(ACP196),"Acalabrutinib (INN)"
,"Acalabrutinib (USAN:INN)",acalabrutinibum,"Calquence (TN)",ACP-196;Acalabrutinib,ACP196;Acalabrutinib,GTPL8912,Acalabr,T3626}

> <pdid>
PD049821

> <targets>
{BTK}

> <classes>
{Angiogenesis}

> <pubchem_cids>
{71226662}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  1  0            999 V2000
    3.8991   -0.7525    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 N   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    6.4978   -0.7562    0.0000 N   0  0
    6.4979    0.7438    0.0000 C   0  0
    7.7969    1.4938    0.0000 C   0  0
    9.0960    0.7438    0.0000 O   0  0
    9.0960   -0.7562    0.0000 C   0  0
    7.7969   -1.5062    0.0000 C   0  0  1  0  0  0
    7.7970   -3.0062    0.0000 C   0  0
    3.8947   -5.2537    0.0000 C   0  0
    5.1944   -6.0042    0.0000 S   0  0  1  0  0  0
    5.1952   -7.5042    0.0000 O   0  0
    6.4937   -6.7537    0.0000 N   0  0
    6.4932   -5.2539    0.0000 C   0  0
    3.2601   -6.4862    0.0000 C   0  0
    2.5100   -5.1872    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114    2.9665    0.0000 N   0  0
    1.8032    3.1233    0.0000 C   0  0
    2.4133    1.7530    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  7  1  0
 12 13  1  1
  4 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  2  0
 15 18  1  1
 14 19  1  0
 19 20  1  0
 20 14  1  0
  2 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 23 27  1  0
 27 28  1  0
 28 29  2  0
 29 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28854

> <plate>
Kinase v5-3

> <well>
G06

> <supplier_cmpd_name>
AZD6738

> <ctcr_id>
11603

> <supplier_cmpd_id>
S7693

> <smiles>
n1c(nc(cc1N1CCOC[C@H]1C)C1([S@@](=O)(=N)C)CC1)c1c2c(ncc1)[nH]cc2

> <pd_targets>
{MTOR,ATR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily","ATR subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","DNA Repair","RNA Polymerase II Transcription","DNA Double-Strand Break Repair","Generic Transcription Pathway","Homology Directed Repair","Transcriptional Regulatio
n by TP53","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Regulation of TP53 Activity","HDR through Homologous Recombination (HRR)","Regulation of TP53 Expression and D
egradation","Homologous DNA Pairing and Strand Exchange","Regulation of TP53 Degradation","Presynaptic phase of homologous DNA pairing and strand exchange"}

> <broad_targets>
{ATR}

> <broad_moa>
{"ATR kinase inhibitor"}

> <synonyms>
{Ceralasertib,AZD6738,1352226-88-0,1352226880,AZD-6738,CHEMBL4285417,BDBM50468001,BDBM60432,"AZD 6738","Ceralasertib (USAN/INN)",GTPL9390,SCHEMBL9979340,EX-A1101,EXA1101,MFCD29472273,NSC780249,NSC8009
79,s7693,"1352226-88-0 (free base)","1352226880 (free base)",AKOS032960475,ZINC143911816,CCG,T3338}

> <pdid>
PD012266

> <targets>
{ATM/ATR,ATR}

> <classes>
{"DNA Damage/DNA Repair","PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{54761306}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  0  0            999 V2000
    3.8988   -3.7512    0.0000 C   0  0
    2.5997   -3.0012    0.0000 N   0  0
    1.3009   -3.7516    0.0000 C   0  0
    2.5988   -1.5004    0.0000 S   0  0
    3.8982   -2.2498    0.0000 O   0  0
    3.8976   -0.7500    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1065    0.0000    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6588   -2.9478    0.0000 C   0  0
   -5.2521   -4.3116    0.0000 N   0  0
   -6.7425   -4.1498    0.0000 C   0  0
   -7.8605   -5.1498    0.0000 C   0  0
   -9.2856   -4.6816    0.0000 C   0  0
   -9.5926   -3.2133    0.0000 C   0  0
   -8.4746   -2.2133    0.0000 C   0  0
   -7.0495   -2.6815    0.0000 C   0  0
   -5.7489   -1.9360    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  2  0
  4  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  2  3
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  2  0
 23 24  1  0
 24 16  2  0
 14 25  1  0
 25 10  1  0
 25 26  2  0
 26  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28856

> <plate>
Kinase v5-3

> <well>
G10

> <supplier_cmpd_name>
SU6656

> <ctcr_id>
6535

> <supplier_cmpd_id>
S7774

> <smiles>
CN(C)[S](=O)(=O)c1ccc2NC(=O)C(=Cc3[nH]c4CCCCc4c3)c2c1

> <pd_targets>
{ALDH1A1,STK3,PMP22,AMPC,SRC,BRSK2,ALK,NFKB1,BLM,FYN,AURKB,RECQL,KMT2A,RAB9A,STAT6,CHRM1,HBB,CYP2C9,GMNN,LCK,AURKC,YES1,LYN,MAPT,NPC1,CYP2D6,MAPK1,FLT3,MEN1,CYP2C19,CYP1A2,LMNA,ALOX15,NPSR1,CYP3A4,SMN
1,FTL,HIF1A,TGR,LEF,RET,MTOR}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Other cytosolic protein","Epigenetic regulator","Transcription factor","Membrane receptor","Secreted protein",Transporter,"Other nuclear protein",Oxidoreductase,Kinase,
Hydrolase,Reader,"Family A G protein-coupled receptor","Cytochrome P450",Protease,"Protein Kinase",Bromodomain,"Small molecule receptor (family A GPCR)","Cytochrome P450 family 2","Cysteine protease",
"Cytochrome P450 family 1","Peptide receptor (family A GPCR)","Cytochrome P450 family 3","Methyl-lysine/arginine binding protein","Metallo protease","STE protein kinase group","TK protein kinase group
","CAMK protein kinase group","TKL protein kinase group","Other protein kinase group","Monoamine receptor","Cytochrome P450 family 2C","Cysteine protease CA clan","Cytochrome P450 family 2D","CMGC pro
tein kinase group","Cytochrome P450 family 1A","Short peptide receptor (family A GPCR)","Cytochrome P450 family 3A","Tudor domain","Metallo protease MAE clan","Atypical protein kinase group","STE prot
ein kinase STE20 family","Tyrosine protein kinase Src family","CAMK protein kinase CAMK1 family","TKL protein kinase STKR family","Other protein kinase AUR family","Acetylcholine receptor","Cytochrome
 P450 2C9","Cysteine protease C1A family","Cytochrome P450 2D6","CMGC protein kinase MAPK family","Tyrosine protein kinase PDGFR family","Cytochrome P450 2C19","Cytochrome P450 1A1","Neuropeptide rece
ptor","Cytochrome P450 3A4","Metallo protease M34 family","Tyrosine protein kinase Ret family","Atypical protein kinase PIKK family","STE protein kinase MST subfamily","CAMK protein kinase BRSK subfam
ily","TKL protein kinase STKR Type 1 subfamily","Tyrosine protein kinase SrcA","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets",Transporters,"Kinases (EC 2.7.x.x)","Catalytic receptors","Chromatin modifying enzymes","Transcription factors","G protein-coupled receptors","Cytochrome P45
0","SLC superfamily of solute carriers","Eicosanoid turnover","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein kinase
s","2.1.1.43 Histone methyltransferases (HMTs)","STAT transcription factors","Acetylcholine receptors (muscarinic)","CYP2 family: drug metabolising subset","SLC65 NPC-type cholesterol transporters","C
MGC: Containing CDK",MAPK,GSK3,"CLK families","CYP1 family",Lipoxygenases,"Neuropeptide S receptor","CYP3 family",Atypical,"STE20 family","TK: Tyrosine kinase","CAMK-like (CAMKL) family","Other protei
n kinases","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","MST subfamily","Non-receptor tyrosine kinases (nRTKs)","BRSK subfamily","R
eceptor tyrosine kinases (RTKs)","Aurora kinase (Aur) family","ERK subfamily","FRAP subfamily","Src family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type III RTKs: PDGFR",CSFR
,Kit,"FLT3 receptor family","Type XIV RTKs: RET"}

> <pathway_reactome>
{Metabolism,"Signal Transduction","Developmental Biology","Immune System","DNA Repair",Disease,"Cell Cycle","Gene expression (Transcription)","Neuronal System","Transport of small molecules","Metaboli
sm of RNA","Vesicle-mediated transport","Cellular responses to external stimuli","Biological oxidations","Signaling by Hippo","Nervous system development","Signaling by Receptor Tyrosine Kinases","Cyt
okine Signaling in Immune system","DNA Double-Strand Break Repair","Infectious disease",Mitotic,"RNA Polymerase II Transcription","Signaling by Rho GTPases","Innate Immune System","Signaling by GPCR",
"Transmission across Chemical Synapses","Plasma lipoprotein assembly",remodeling,"and clearance","Metabolism of lipids","Metabolism of non-coding RNA","Membrane Trafficking","Cellular responses to str
ess","Phase I - Functionalization of compounds","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Signaling by NTRKs","Signaling by Interleukins","Homology Directed Repair","HIV Infect
ion","M Phase","Generic Transcription Pathway","Rho GTPase cycle","Cytosolic sensors of pathogen-associated DNA","GPCR ligand binding","Neutrophil degranulation","Mitotic G1 phase and G1/S transition"
,"Leishmania infection","Neurotransmitter receptors and postsynaptic signal transmission","Plasma lipoprotein clearance","Toll-like Receptor Cascades","Signaling by Insulin receptor","Biosynthesis of 
specialized proresolving mediators (SPMs)","snRNP Assembly","trans-Golgi Network Vesicle Budding","Cellular response to hypoxia","Uptake and actions of bacterial toxins","Axon guidance","Ethanol oxida
tion","Signaling by NTRK1 (TRKA)","Interleukin-1 family signaling","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Host Interactions of HIV factors","Mitotic Metaphase a
nd Anaphase","Transcriptional regulation by RUNX1","RHOBTB GTPase Cycle","STING mediated induction of host immune responses","Class A/1 (Rhodopsin-like receptors)","Cytochrome P450 - arranged by subst
rate type","G1/S Transition","Leishmania parasite growth and survival","Activation of NMDA receptors and postsynaptic events","LDL clearance","Toll Like Receptor 5 (TLR5) Cascade","Insulin receptor si
gnalling cascade","Biosynthesis of DPA-derived SPMs","Biosynthesis of DHA-derived SPMs","Golgi Associated Vesicle Biogenesis","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"
,"Uptake and function of anthrax toxins","RET signaling","Transcriptional Regulation by TP53","Signalling to ERKs","Interleukin-1 signaling","HDR through Homologous Recombination (HRR)","The role of N
ef in HIV-1 replication and disease pathogenesis","Mitotic Anaphase","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","RHOBTB3 ATPase cycle","STAT6-mediated indu
ction of chemokines","Amine ligand-binding receptors",Xenobiotics,"Activation of the pre-replicative complex","Anti-inflammatory response favouring Leishmania parasite infection","Post NMDA receptor a
ctivation events","MyD88 cascade initiated on plasma membrane","IRS-mediated signalling","Biosynthesis of DPAn-3 SPMs","Biosynthesis of maresins","Regulation of TP53 Activity","Signalling to RAS","MAP
3K8 (TPL2)-dependent MAPK1/3 activation","Homologous DNA Pairing and Strand Exchange","Nef and signal transduction","Separation of Sister Chromatids","Muscarinic acetylcholine receptors","CYP2E1 react
ions","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-mediated IL10 synthesis","Activation of AMPK downstream of NMDARs","MAP kinase activation
","PI3K Cascade","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Nuclear Envelope (NE) Reassembly","Biosynthesis of DPAn-3-derived protectins and resolvins","ADORA2B mediated anti-
inflammatory cytokines production","Biosynthesis of maresin-like SPMs","Regulation of TP53 Expression and Degradation","p38MAPK events","Presynaptic phase of homologous DNA pairing and strand exchange
","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","Initiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation","ERK/MAPK targets","ERKs 
are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SCHEMBL1737451,CHEBI:91462,DTXSID601017226,HMS3372L02,BCP14728,NCGC00346933-01,NCGC0034693301,AK547748,FT-0700292,FT0700292,T6997,"EMD 572635",SU6656,572635,"SU 6656"}

> <pdid>
PD002623

> <targets>
{Src,SRC}

> <classes>
{}

> <pubchem_cids>
{5309}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 38  0  0  1  0            999 V2000
   10.3543    1.2910    0.0000 C   0  0
    9.6042   -0.0080    0.0000 C   0  0
   10.3542   -1.3071    0.0000 N   0  0
    9.6041   -2.6061    0.0000 C   0  0
    8.1041   -2.6061    0.0000 C   0  0
    7.3541   -1.3070    0.0000 C   0  0
    8.1042   -0.0080    0.0000 C   0  0
    5.8533   -1.3039    0.0000 C   0  0
    5.1064   -0.0031    0.0000 O   0  0
    5.0993   -2.6016    0.0000 N   0  0
    3.6011   -2.5985    0.0000 C   0  0
    2.7244   -1.3814    0.0000 N   0  0
    1.2968   -1.8390    0.0000 C   0  0
    1.2906   -3.3390    0.0000 C   0  0
    2.7144   -3.8084    0.0000 N   0  0
    3.1721   -5.2376    0.0000 C   0  0  2  0  0  0
    2.1706   -6.3572    0.0000 C   0  0
    2.4076   -7.8383    0.0000 C   0  0
    3.7133   -8.5765    0.0000 C   0  0
    5.1046   -8.0159    0.0000 C   0  0
    5.5338   -6.5786    0.0000 N   0  0
    4.6776   -5.3470    0.0000 C   0  0
    7.0172   -6.3382    0.0000 C   0  0
    7.9650   -7.5008    0.0000 O   0  0
    7.5509   -4.9355    0.0000 C   0  0
    9.0324   -4.6954    0.0000 C   0  0
    9.5661   -3.2927    0.0000 C   0  0
   11.0476   -3.0525    0.0000 N   0  0
   11.5810   -1.6506    0.0000 C   0  0
   11.9954   -4.2152    0.0000 C   0  0
   -0.0116   -4.0836    0.0000 C   0  0
   -1.3075   -3.3282    0.0000 C   0  0
   -1.3013   -1.8282    0.0000 C   0  0
    0.0009   -1.0836    0.0000 C   0  0
   -0.0178   -5.5836    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  6  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 11  1  0
 16 15  1  1
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 16  1  0
 21 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 14 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  2  0
 34 13  1  0
 31 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
28857

> <plate>
Kinase v5-3

> <well>
G12

> <supplier_cmpd_name>
Nazartinib (EGF816, NVS-816)

> <ctcr_id>
11546

> <supplier_cmpd_id>
S7824

> <smiles>
Cc1nccc(c1)C(=O)Nc1nc2c(n1[C@@H]1CCCCN(C1)C(=O)/C=C/CN(C)C)c(ccc2)Cl

> <pd_targets>
{CYP2D6,EGFR,ERBB2,ERBB3,ERBB4}

> <pathway_gtopdb>
{Enzyme,"Cytochrome P450",Kinase,"Cytochrome P450 family 2","Protein Kinase","Cytochrome P450 family 2D","TK protein kinase group","Cytochrome P450 2D6","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Catalytic receptors","CYP2 family: drug metabolising subset","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epide
rmal growth factor) receptor family"}

> <pathway_reactome>
{Metabolism,"Signal Transduction","Biological oxidations","Signaling by GPCR","Phase I - Functionalization of compounds","GPCR downstream signalling","Cytochrome P450 - arranged by substrate type","G 
alpha (q) signalling events",Xenobiotics,"Gastrin-CREB signalling pathway via PKC and MAPK","CYP2E1 reactions","EGFR Transactivation by Gastrin"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{s7824,ZINC210610738,nazartinib,EGF816,1508250-71-2,1508250712,EGF-816,UNII-KE7K32EME8,UNIIKE7K32EME8,"EGF 816",NVP-EGF816-NX,NVPEGF816NX,KE7K32EME8,CHEMBL3787344,"Nazartinib (EGF816, NVS-816)","Nazar
tinib (EGF816, NVS816)","Nazartinib (USAN)",Nazartinib(EGF816),"Nazartinib (USAN/INN)",GTPL9204,SCHEMBL16767232,S,T3506,Nazartinib}

> <pdid>
PD051464

> <targets>
{EGFR,"EGFR (mutant)"}

> <classes>
{Angiogenesis,"JAK/STAT signaling","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{72703790}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2990   -5.2508    0.0000 C   0  0
   -2.5969   -6.0029    0.0000 C   0  0
   -2.5945   -7.5029    0.0000 N   0  0
   -1.2942   -8.2509    0.0000 C   0  0
    0.0036   -7.4988    0.0000 C   0  0
    0.0012   -5.9988    0.0000 C   0  0
   -1.2919   -9.7516    0.0000 C   0  0
   -2.5026  -10.6153    0.0000 N   0  0
   -2.0346  -12.0404    0.0000 C   0  0
   -0.5346  -12.0357    0.0000 N   0  0
   -0.0756  -10.6076    0.0000 N   0  0
   -3.8971   -5.2551    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  3  1  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 20  1  0
 15 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28858

> <plate>
Kinase v5-3

> <well>
G14

> <supplier_cmpd_name>
CC-115

> <ctcr_id>
11633

> <supplier_cmpd_id>
S7891

> <smiles>
CCN1C(=O)CNc2ncc(nc12)c1c(nc(cc1)c1ncn[nH]1)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{C11,cc-115,cc115,1228013-15-7,1228013157,CC115,UNII-FII75TFH5L,UNIIFII75TFH5L,FII75TFH5L,CHEMBL3586573,"1228013-15-7 (free base)","1228013157 (free base)","CC 115",SCHEMBL135765,SCHEMBL14877034,BCP16
702,EX-A3190,EXA3190,BDBM50093082,MFCD29036965,NSC793151,s7891,AKOS030526334,ZINC113191351,CCG-267869,CCG267869,CS-4561,CS4561,DB12740,T3541,CC-115}

> <pdid>

> <targets>
{DNA-PK,mTOR,PI3K¦Á}

> <classes>
{"DNA Damage/DNA Repair","PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{58298318}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    9.0994   -0.7675    0.0000 C   0  0
    9.1044    0.7325    0.0000 O   0  0
    7.7969   -1.5132    0.0000 C   0  0
    6.4994   -0.7589    0.0000 O   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -4.9971   -6.2653    0.0000 C   0  0
   -4.3823   -7.6335    0.0000 N   0  0
   -2.8911   -7.4716    0.0000 N   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   10.3968   -1.5218    0.0000 N   0  0
   11.6993   -0.7762    0.0000 C   0  0
   12.9961   -1.5301    0.0000 C   0  0
   11.7043    0.7238    0.0000 C   0  0
  1  2  2  0
  1  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  7 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 15 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 20  2  0
 24 25  1  0
 25 26  2  0
 26 18  1  0
 14 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 13  1  0
  1 31  1  0
 31 32  1  0
 32 33  1  0
 32 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28859

> <plate>
Kinase v5-3

> <well>
G16

> <supplier_cmpd_name>
KD025 (SLx-2119)

> <ctcr_id>
11625

> <supplier_cmpd_id>
Se S7936

> <smiles>
C(=O)(COc1cc(ccc1)c1nc2c(c(n1)Nc1cc3cn[nH]c3cc1)cccc2)NC(C)C

> <pd_targets>
{STK3,CLK2,CSNK2A1,CLK4,ROCK2,ROCK1,AURKB,STK17A,DYRK1A,BLK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","CMGC protein kinase group","Other protein kinase group","AGC protein kinase group","CAMK protein kinase group","TK protein kinase group","ST
E protein kinase STE20 family","CMGC protein kinase CLK family","Other protein kinase CK2 family","AGC protein kinase DMPK family","Other protein kinase AUR family","CAMK protein kinase DAPK family","
CMGC protein kinase DYRK family","Tyrosine protein kinase Src family","STE protein kinase MST subfamily","AGC protein kinase ROCK subfamily","CMGC protein kinase Dyrk1 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases",
"AGC: Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","STE20 family","CLK family","Other protein kinases","DMPK family","Death-associated kinase (DAPK) family",
"Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","TK: Tyrosine kinase","MST subfamily","Casein kinase 2 (CK2) family","Rho kinase","Aurora kinase (Aur) family","Dyrk1 sub
family","Non-receptor tyrosine kinases (nRTKs)","Src family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Developmental Biology","Cell Cycle","Signaling by Hippo","RNA Polymerase II Transcription","Nervous system development",Mitotic,"Generic Trans
cription Pathway","Axon guidance","M Phase","Mitotic G1 phase and G1/S transition","Transcriptional Regulation by TP53","Semaphorin interactions","Mitotic Metaphase and Anaphase","G0 and Early G1","Tr
anscriptional regulation by RUNX1","Regulation of TP53 Activity","Sema4D in semaphorin signaling","Mitotic Anaphase","RUNX1 regulates transcription of genes involved in BCR signaling","Regulation of T
P53 Activity through Phosphorylation","Sema4D induced cell migration and growth-cone collapse","Separation of Sister Chromatids"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"US10570123, Example 232",CCG-269256,CCG269256,CS-0776,CS0776,SB16915,"SLx-2119; KD-025","SLx2119; KD025",911417-87-3,911417873,SLx-2119,SLx2119,KD-025,KD025,Belumosudil,"ROCK inhibitor 2",UNII-834YJ
F89WO,UNII834YJF89WO,"SLx 2119","KD025 (SLx-2119)","KD025 (SLx2119)",834YJF89WO,C26H24N6O2,2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-y,2(3(4(1Hindazol5ylamino)quinazolin2y,T6867}

> <pdid>
PD012898

> <targets>
{ROCK,ROCK2}

> <classes>
{Cell Cycle/Checkpoint,Stem Cells,Cell Cycle/DNA Damage,Cytoskeleton,Stem Cell/Wnt,TGF-beta/Smad}

> <pubchem_cids>
{11950170}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  1  0            999 V2000
    3.8934   -5.2570    0.0000 C   0  0  2  0  0  0
    5.1924   -6.0070    0.0000 C   0  0
    6.4915   -5.2571    0.0000 N   0  0
    6.4915   -3.7571    0.0000 C   0  0
    5.1925   -3.0070    0.0000 C   0  0
    3.8933   -3.7570    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -2.6012   -3.0008    0.0000 N   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -5.2141   -7.4949    0.0000 Cl  0  0
   -2.6108   -6.0040    0.0000 F   0  0
    2.5972    1.5031    0.0000 O   0  0
    2.5951    3.0031    0.0000 C   0  0
    7.7905   -6.0071    0.0000 C   0  0
    2.5944   -6.0070    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 13  1  0
 16 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 23 27  1  0
 22 28  1  0
 11 29  1  0
 29 30  1  0
  3 31  1  0
  1 32  1  1
M  END
> <name>
UTKinase_V5

> <id>
28860

> <plate>
Kinase v5-3

> <well>
G18

> <supplier_cmpd_name>
AZD3759

> <ctcr_id>
11537

> <supplier_cmpd_id>
S7971

> <smiles>
[C@H]1(CN(CCN1C(=O)Oc1c(cc2c(c1)c(ncn2)Nc1c(c(ccc1)Cl)F)OC)C)C

> <pd_targets>
{SRC,EGFR,ERBB2,ERBB3,ERBB4,KCNH2,KDR,DRD2}

> <pathway_gtopdb>
{Enzyme,"Ion channel","Membrane receptor",Kinase,"Voltage-gated ion channel","Family A G protein-coupled receptor","Protein Kinase","Potassium channels","Small molecule receptor (family A GPCR)","TK p
rotein kinase group","Voltage-gated potassium channel","Monoamine receptor","Tyrosine protein kinase Src family","Tyrosine protein kinase EGFR family","Tyrosine protein kinase VEGFR family","Dopamine 
receptor"}

> <pathway_chembl>
{Receptors,"Ion channels","Catalytic receptors","Voltage-gated ion channels","G protein-coupled receptors","Receptor kinases","Potassium channels","Dopamine receptors","TK: Tyrosine kinase","Voltage-g
ated potassium channels","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type I RTKs:
 ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Muscle contraction","Signaling by Receptor Tyrosine Kinases","Cardiac conduction","Signaling by GPCR","Signaling by NTRKs","Phase 3 - rapid repolarisation","Signaling by VEGF",
"GPCR ligand binding","GPCR downstream signalling","Signaling by NTRK1 (TRKA)","VEGFA-VEGFR2 Pathway","Class A/1 (Rhodopsin-like receptors)","G alpha (q) signalling events","Signalling to ERKs","VEGFR
2 mediated cell proliferation","Amine ligand-binding receptors","Gastrin-CREB signalling pathway via PKC and MAPK","Signalling to RAS","Dopamine receptors","EGFR Transactivation by Gastrin","p38MAPK e
vents"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{AZD3759,1626387-80-1,1626387801,AZD-3759,zorifertinib,"AZD 3759",UNII-67SX9H68W2,UNII67SX9H68W2,CHEMBL3623290,67SX9H68W2,SCHEMBL16010006,GTPL10456,EX-A720,EXA720,AMY10302,BDBM50123453,MFCD29058564,NS
C788121,NSC800978,s7971,AKOS027327321,ZINC221149242,CCG-269329,CCG269329,CS-5029,CS5029,DB14795,NS,T4249,T3659,"AZD3759 hydrochloride"}

> <pdid>
PD012284

> <targets>
{EGFR,"EGFR (exon 19Del)","EGFR (L858R)","EGFR (WT)"}

> <classes>
{Angiogenesis,"JAK/STAT signaling","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{78209992}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 38  0  0  0  0            999 V2000
    7.7999   -3.0121    0.0000 C   0  0
    9.0950   -3.7689    0.0000 N   0  0
    9.0867   -5.2697    0.0000 C   0  0
   10.3832   -6.0242    0.0000 C   0  0
   10.3780   -7.5242    0.0000 C   0  0
    9.0764   -8.2697    0.0000 C   0  0
    7.7800   -7.5152    0.0000 C   0  0
    7.7850   -6.0152    0.0000 C   0  0
    6.4863   -5.2630    0.0000 C   0  0
    5.1851   -6.0107    0.0000 N   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1065    0.0000    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.2935   -3.7495    0.0000 N   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    2.5795   -7.5048    0.0000 C   0  0
    1.2784   -8.2511    0.0000 F   0  0
    3.8762   -8.2589    0.0000 F   0  0
    2.5751   -9.0048    0.0000 F   0  0
   10.3984   -3.0249    0.0000 S   0  0
   11.7015   -2.2818    0.0000 C   0  0
   10.4067   -1.5249    0.0000 O   0  0
   11.6935   -3.7816    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 18  1  0
 23 24  2  0
 24 15  1  0
 13 25  2  0
 25 26  1  0
 26 27  2  0
 27 11  1  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 28 31  1  0
  2 32  1  0
 32 33  1  0
 32 34  2  0
 32 35  2  0
M  END
> <name>
UTKinase_V5

> <id>
28861

> <plate>
Kinase v5-3

> <well>
J08

> <supplier_cmpd_name>
PF-431396

> <ctcr_id>
4503

> <supplier_cmpd_id>
S7644

> <smiles>
CN(c1ccccc1CNc2nc(Nc3ccc4NC(=O)Cc4c3)ncc2C(F)(F)F)[S](C)(=O)=O

> <pd_targets>
{BRD4,PTK2,PTK2B,AURKA}

> <pathway_gtopdb>
{"Epigenetic regulator",Enzyme,Reader,Kinase,Bromodomain,"Protein Kinase","TK protein kinase group","Other protein kinase group","Tyrosine protein kinase Fak family","Other protein kinase AUR family"}

> <pathway_chembl>
{Enzymes,Receptors,"Chromatin modifying enzymes","Catalytic receptors","Enzymatic bromodomain-containing proteins","Receptor kinases","Bromodomain kinase (BRDK) family","TK: Tyrosine kinase","Other pr
otein kinases","Non-receptor tyrosine kinases (nRTKs)","Aurora kinase (Aur) family","Fak family"}

> <pathway_reactome>
{Disease,"Immune System","Gene expression (Transcription)","Infectious disease","Cytokine Signaling in Immune system","RNA Polymerase II Transcription","SARS-CoV Infections","Leishmania infection","Si
gnaling by Interleukins","Generic Transcription Pathway","Potential therapeutics for SARS","Parasite infection","Interleukin-2 family signaling","Transcriptional Regulation by TP53","Leishmania phagoc
ytosis","Interleukin-2 signaling","Regulation of TP53 Activity","FCGR3A-mediated phagocytosis","Regulation of TP53 Activity through Phosphorylation"}

> <broad_targets>
{PTK2,PTK2B}

> <broad_moa>
{"focal adhesion kinase inhibitor"}

> <synonyms>
{PF-431396,PF431396,"PF 431396",717906-29-1,717906291,CHEMBL472212,C22H21F3N6O3S,3fzr,"CID 11598628",SCHEMBL3144824,CHEBI:91388,AOB6096,DTXSID50469204,EX-A787,EXA787,SYN1063,BCPP000115,HMS3244D04,HMS3
244D08,HMS3244D12,HMS3295C21,HMS3750E11,BCP01974,2637AH,ABP00051,T2314,SY-PF431396}

> <pdid>
PD016438

> <targets>
{FAK,PYK2}

> <classes>
{}

> <pubchem_cids>
{11598628}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    7.0625   -7.0106    0.0000 C   0  0
    6.3098   -5.7131    0.0000 C   0  0
    4.8090   -5.7153    0.0000 C   0  0
    4.0559   -4.4171    0.0000 N   0  0
    2.5551   -4.4192    0.0000 C   0  0
    1.8073   -5.7196    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.6003   -1.4978    0.0000 N   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -3.8939    0.7546    0.0000 C   0  0
   -5.1904    1.5090    0.0000 C   0  0
   -6.4920    0.7635    0.0000 C   0  0
   -6.4971   -0.7365    0.0000 C   0  0
   -5.2007   -1.4909    0.0000 C   0  0
   -5.2059   -2.9909    0.0000 C   0  0
   -5.1883    3.0099    0.0000 C   0  0
   -3.8879    3.7577    0.0000 O   0  0
   -6.4865    3.7629    0.0000 N   0  0
   -6.4844    5.2637    0.0000 C   0  0
   -7.2302    6.4740    0.0000 C   0  0
   -5.7302    6.4687    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
   -0.6923   -4.0811    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 20 21  1  0
 17 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 25  1  0
 13 28  1  0
 28  9  1  0
 28 29  2  0
 29  7  1  0
 29 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28862

> <plate>
Kinase v5-3

> <well>
I20

> <supplier_cmpd_name>
BMS-582949

> <ctcr_id>
12378

> <supplier_cmpd_id>
S8124

> <smiles>
CCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NC3CC3)c2c1C

> <pd_targets>
{MAPK14,MAPK11,CYP3A4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 3","CMGC protein kinase group","Cytochrome P450 family 3A","CMGC protein kinase MAPK family","Cytochrome P450 3A4","CMGC prote
in kinase p38 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Cytochrome P450","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP3 family","Mitogen-activated protein kinases (MAP kinases)","p38 subfamily"}

> <pathway_reactome>
{"Immune System",Metabolism,"Innate Immune System","Metabolism of lipids","Toll-like Receptor Cascades","Biosynthesis of specialized proresolving mediators (SPMs)","Toll Like Receptor 5 (TLR5) Cascade
","Biosynthesis of DHA-derived SPMs","MyD88 cascade initiated on plasma membrane","Biosynthesis of maresins","MAP kinase activation","Biosynthesis of maresin-like SPMs","MAPK targets/ Nuclear events m
ediated by MAP kinases","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{MS58294,BMS-582949,BMS582949,623152-17-0,623152170,"BMS 582949",UNII-CR743OME9E,UNIICR743OME9E,PS540446,"BMS582949 free base",CR743OME9E,CHEMBL1230065,"623152-17-0 (free base)","623152170 (free base)
",PS-540446,3mvl,SCHEMBL254996,GTPL7838,DTXSID90211380,BCP14356,EX-A1265,EXA1265,BDBM50327009,MFCD18633248,NSC,T6789,T3462,"BMS-582949 HCl"}

> <pdid>
PD050860

> <targets>
{"p38 MAPK"}

> <classes>
{MAPK}

> <pubchem_cids>
{10409068}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  1  0            999 V2000
    1.2991   -0.7517    0.0000 C   0  0
    2.5998   -1.4987    0.0000 C   0  0  2  0  0  0
    2.6028   -2.9995    0.0000 C   0  0
    3.8190   -3.8555    0.0000 N   0  0
    3.3600   -5.2835    0.0000 N   0  0
    1.8608   -5.2881    0.0000 C   0  0
    1.3928   -3.8630    0.0000 N   0  0
   -0.0754   -3.5558    0.0000 C   0  0
   -1.0756   -4.6737    0.0000 C   0  0
   -0.6075   -6.0988    0.0000 C   0  0
    0.8607   -6.4060    0.0000 C   0  0
    1.3287   -7.8311    0.0000 F   0  0
   -2.5445   -4.3663    0.0000 C   0  0
   -3.1398   -3.0034    0.0000 C   0  0
   -4.6308   -3.1673    0.0000 N   0  0
   -4.9357   -4.6360    0.0000 N   0  0
   -3.6331   -5.3798    0.0000 C   0  0
   -5.6398   -2.0574    0.0000 C   0  0
    3.8976   -0.7448    0.0000 N   0  0
    3.8917    0.7552    0.0000 C   0  0
    5.1877    1.5103    0.0000 C   0  0
    6.4897    0.7655    0.0000 C   0  0
    7.7858    1.5206    0.0000 N   0  0
    9.0878    0.7758    0.0000 C   0  0
    9.0937   -0.7242    0.0000 C   0  0
    7.7977   -1.4794    0.0000 C   0  0
    6.4957   -0.7345    0.0000 C   0  0
    5.1996   -1.4897    0.0000 C   0  0
    5.2056   -2.9897    0.0000 O   0  0
   10.3949   -1.4722    0.0000 O   0  0
   10.3987   -2.9730    0.0000 C   0  0
   11.6999   -3.7209    0.0000 C   0  0
   11.7037   -5.2217    0.0000 O   0  0
   13.0042   -5.9693    0.0000 C   0  0
  2  1  1  1
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  3  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
  9 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 13  1  0
 15 18  1  0
  2 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
 28 19  1  0
 28 29  2  0
 25 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28863

> <plate>
Kinase v5-3

> <well>
I22

> <supplier_cmpd_name>
AMG 337

> <ctcr_id>
12600

> <supplier_cmpd_id>
S8167

> <smiles>
C[C@H](c1nnc2n1cc(cc2F)c1cn(nc1)C)n1ccc2ncc(cc2c1=O)OCCOC

> <pd_targets>
{CYP3A4,MET}

> <pathway_gtopdb>
{Enzyme,"Cytochrome P450",Kinase,"Cytochrome P450 family 3","Protein Kinase","Cytochrome P450 family 3A","TK protein kinase group","Cytochrome P450 3A4","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Enzymes,Receptors,"Cytochrome P450","Catalytic receptors","CYP3 family","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) recept
or family"}

> <pathway_reactome>
{Metabolism,"Developmental Biology","Metabolism of lipids","Nervous system development","Biosynthesis of specialized proresolving mediators (SPMs)","Axon guidance","Biosynthesis of DHA-derived SPMs","
Semaphorin interactions","Biosynthesis of maresins","Sema4D in semaphorin signaling","Biosynthesis of maresin-like SPMs","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{MET}

> <broad_moa>
{"MET inhibitor"}

> <synonyms>
{MG33,"MG 33",AMG-337,AMG337,"AMG 337",1173699-31-4,1173699314,"1173699 31 4",UNII-08WG8S0L8D,UNII08WG8S0L8D,"UNII 08WG8S0L8D",08WG8S0L8D,CHEMBL3785909,GTPL8913,SCHEMBL4304600,"AMG 337 (WHO-DD)","AMG 
337 (WHODD)","AMG 337 (WHO DD)",BCP16602,BDBM50157612,MFCD29472283,NSC789223,NSC800996,s8167,ZINC144562400,CCG-269379,CCG269379,"CCG 269379",CS-5281,CS5281,"CS 5281",NSC-789223,"NSC 789223",NSC-800996
,"NSC 800996",SB19194,compoun,T3209}

> <pdid>
PD071529

> <targets>
{c-Met,Met,Met(H1094R),Met(M1250T),Met(V1092I),Met(Y1230H)}

> <classes>
{"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{44181686}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 31  0  0  0  0            999 V2000
    5.1065    0.0000    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.7248    1.2135    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 N   0  0
   -2.7390    2.9810    0.0000 C   0  0
   -4.2067    3.2905    0.0000 C   0  0
   -4.9546    1.9903    0.0000 C   0  0
   -3.9492    0.8772    0.0000 N   0  0
   -4.8211    4.6570    0.0000 C   0  0
   -3.9435    5.8735    0.0000 O   0  0
   -6.3142    4.8094    0.0000 C   0  0
   -7.0490    6.1024    0.0000 C   0  0
   -8.5138    5.7830    0.0000 C   0  0
   -9.7318    6.6585    0.0000 C   0  0
  -11.0990    6.0414    0.0000 C   0  0
  -11.2482    4.5488    0.0000 C   0  0
  -10.0302    3.6733    0.0000 C   0  0
   -8.6630    4.2904    0.0000 C   0  0
   -7.2904    3.6874    0.0000 N   0  0
   -1.6199    3.9799    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  2  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  4  1  0
  8 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 11  1  0
 13 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 25 26  1  0
 26 18  1  0
 12 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28864

> <plate>
Kinase v5-3

> <well>
I04

> <supplier_cmpd_name>
CH5183284 (Debio-1347)

> <ctcr_id>
12542

> <supplier_cmpd_id>
S7665

> <smiles>
Cc1nc2c([nH]1)cc(cc2)n1c(c(cn1)C(=O)c1cc2ccccc2[nH]1)N

> <pd_targets>
{FGFR3,FGFR4,FGFR1,KDR,FGFR2,SRC,GSC2,PDGFRB,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,Transferase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","TK protein kinase group","Voltage-gated potassium channel","Tyrosine protein kinase FGFR fam
ily","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Ion channels","Catalytic receptors","Voltage-gated ion channels","Receptor kinases","Potassium channels","TK: Tyrosine kinase","Voltage-gated potassium channels","Receptor tyrosine kinases
 (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Src family","T
ype III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Muscle contraction","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","Intracellular signaling
 by second messengers","Cardiac conduction","Signaling by FGFR in disease","Signaling by FGFR","Signaling by VEGF","Signaling by NTRKs","PIP3 activates AKT signaling","Phase 3 - rapid repolarisation",
"Signaling by FGFR3 in disease","Signaling by FGFR4","Signaling by FGFR1 in disease","VEGFA-VEGFR2 Pathway","Signaling by FGFR2 in disease","Signaling by NTRK1 (TRKA)","Negative regulation of the PI3K
/AKT network","Signaling by FGFR3 point mutants in cancer","Downstream signaling of activated FGFR4","FGFR1 mutant receptor activation","VEGFR2 mediated cell proliferation","FGFR2 mutant receptor acti
vation","Signalling to ERKs",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","FGFR3 mutant receptor activation","FRS-mediated FGFR4 signaling","Signaling by activated point mutants of FGFR1","Activat
ed point mutants of FGFR2","Signalling to RAS","Signaling by activated point mutants of FGFR3","p38MAPK events"}

> <broad_targets>
{FGFR1,FGFR2,FGFR3}

> <broad_moa>
{"fibroblast growth factor inhibitor"}

> <synonyms>
{1265229-25-1,1265229251,Debio-1347,Debio1347,CH5183284,"CH5183284 (Debio-1347)","CH5183284 (Debio1347)",CH-5183284,"Debio 1347",UNII-NR9ZYH80Z8,UNIINR9ZYH80Z8,NR9ZYH80Z8,CHEMBL3907479,FF284,zoligrati
nib,DEBIO1347,GTPL9787,SCHEMBL10002991,HMS3674G21,HMS3748K13,BCP14354,EX-A1122,EXA1122,BDBM50197683,MFCD28502053,N,T6024}

> <pdid>
PD018312

> <targets>
{FGFR,FGFR1,FGFR2,FGFR3,FGFR4}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{66555680}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  1  0            999 V2000
    3.8976   -0.7465    0.0000 C   0  0
    2.5998   -1.4987    0.0000 C   0  0  1  0  0  0
    2.6028   -2.9995    0.0000 N   0  0
    3.9036   -3.7481    0.0000 C   0  0
    3.9087   -5.2482    0.0000 C   0  0
    5.2103   -5.9938    0.0000 C   0  0
    5.2154   -7.4937    0.0000 F   0  0
    6.5068   -5.2394    0.0000 C   0  0
    6.5017   -3.7394    0.0000 C   0  0
    7.7982   -2.9850    0.0000 F   0  0
    5.2001   -2.9938    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -1.2990   -5.2508    0.0000 N   0  0
   -0.0012   -6.0029    0.0000 C   0  0
   -0.0035   -7.5029    0.0000 C   0  0
   -1.3038   -8.2509    0.0000 O   0  0
   -2.6016   -7.4988    0.0000 C   0  0
   -2.5992   -5.9988    0.0000 C   0  0
   -0.0031    3.0008    0.0000 C   0  0
    1.2946    3.7531    0.0000 O   0  0
   -1.3039    3.7494    0.0000 N   0  0
   -1.3070    5.2494    0.0000 C   0  0
   -2.6017    2.9971    0.0000 C   0  0
  2  1  1  1
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  2  0
  8  9  1  0
  9 10  1  0
  9 11  2  0
 11  4  1  0
  2 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 16  1  0
 21 22  2  0
 19 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 23  1  0
 14 29  1  0
 29 30  2  0
 29 31  1  0
 31 32  1  0
 31 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28865

> <plate>
Kinase v5-3

> <well>
I06

> <supplier_cmpd_name>
AZD8186

> <ctcr_id>
12239

> <supplier_cmpd_id>
S7694

> <smiles>
C[C@@H](Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C

> <pd_targets>
{PIK3CA,PIK3CD,PIK3CG,PIK3CB}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family"}

> <pathway_reactome>
{Disease,"Immune System",Metabolism,"Signal Transduction","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Immune system","Metabolism of lipids
","Signaling by Receptor Tyrosine Kinases","Signaling by FGFR in disease","Signaling by Interleukins","Phospholipid metabolism","Signaling by Insulin receptor","Signaling by FGFR1 in disease",Interleu
kin-3,"Interleukin-5 and GM-CSF signaling","PI Metabolism","Insulin receptor signalling cascade","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","Synthesis of PIPs at the plasm
a membrane","IRS-mediated signalling","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade"}

> <broad_targets>
{PIK3CB,PIK3CD}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{AZD8186,1627494-13-6,1627494136,AZD-8186,AIQ4OWD0RA,UNII-AIQ4OWD0RA,UNIIAIQ4OWD0RA,CHEMBL3408248,"AZD 8186",1296270-45-5,1296270455,GTPL8527,SCHEMBL1636956,AMY16571,EX-A1649,EXA1649,BDBM50070322,MFCD
27987908,NSC777572,NSC799352,s7694,AKOS025404922,ZINC116734639,ACN-037528,ACN037528,CCG-269309,CCG269309,CS-4975,CS4975,T6773}

> <pdid>
PD012988

> <targets>
{PI3K,PI3K¦Á,PI3K¦Â,PI3K¦Ã,PI3K¦Ä}

> <classes>
{PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR}

> <pubchem_cids>
{52913813}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.9511   -0.8815    0.0000 N   0  0
   -4.9530   -1.9978    0.0000 C   0  0
   -4.2010   -3.2957    0.0000 N   0  0
   -2.7343   -2.9815    0.0000 C   0  0
   -1.6115   -3.9772    0.0000 C   0  0
   -0.1605   -3.6178    0.0000 C   0  0
    0.8791   -4.6991    0.0000 C   0  0
    0.4626   -6.1401    0.0000 C   0  0
    1.5022   -7.2213    0.0000 F   0  0
   -0.9936   -6.4998    0.0000 C   0  0
   -2.0333   -5.4186    0.0000 C   0  0
   -4.2568    0.5878    0.0000 C   0  0
   -3.2235    1.6679    0.0000 C   0  0
   -3.6446    3.1076    0.0000 C   0  0
   -5.1020    3.4627    0.0000 C   0  0
   -5.5231    4.9024    0.0000 O   0  0
   -6.1382    2.3782    0.0000 C   0  0
   -5.7171    0.9385    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  9  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 14  1  0
 10 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 26 27  1  0
 27 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28866

> <plate>
Kinase v5-3

> <well>
I08

> <supplier_cmpd_name>
SB239063

> <ctcr_id>
4949

> <supplier_cmpd_id>
S7741

> <smiles>
COc1nccc(n1)c2n(cnc2c3ccc(F)cc3)C4CCC(O)CC4

> <pd_targets>
{MAPK14,LCK,MAPK11,PRKCA,MAPK9,EGFR,RAF1,CYP2D6,CYP2C9,CSNK1D,MINK1,KDM4E,MAP4K4,PRKD2,CSNK1A1,CYP2C19,CYP1A2,PRKD3,MAP4K5,RORC,FRK}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Transcription factor",Kinase,"Cytochrome P450",Eraser,"Nuclear receptor","Protein Kinase","Cytochrome P450 family 2","Lysine demethylase","Cytochrome P450 family 1","Nu
clear hormone receptor subfamily 1","CMGC protein kinase group","TK protein kinase group","AGC protein kinase group","TKL protein kinase group","Cytochrome P450 family 2D","Cytochrome P450 family 2C",
"CK1 protein kinase group","STE protein kinase group","Jumonji domain-containing","CAMK protein kinase group","Cytochrome P450 family 1A","Nuclear hormone receptor subfamily 1 group F","CMGC protein k
inase MAPK family","Tyrosine protein kinase Src family","AGC protein kinase PKC family","Tyrosine protein kinase EGFR family","TKL protein kinase RAF family","Cytochrome P450 2D6","Cytochrome P450 2C9
","CK1 protein kinase CK1 family","STE protein kinase STE20 family","CAMK protein kinase PKD family","Cytochrome P450 2C19","Cytochrome P450 1A1","Nuclear hormone receptor subfamily 1 group F member 3
","CMGC protein kinase p38 subfamily","AGC protein kinase PKC alpha subfamily","CMGC protein kinase JNK subfamily","STE protein kinase MSN subfamily","STE protein kinase KHS subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Cytochrome P450","Chromatin modifying enzymes","Nuclear hormone receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor ki
nases","AGC: Containing PKA",PKG,"PKC families","CYP2 family: drug metabolising subset","CK1: Casein kinase 1","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","1.14.11.- Histone d
emethylases","CAMK: Calcium/calmodulin-dependent protein kinases","CYP1 family","1F. Retinoic acid-related orphans","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","Protein kin
ase C (PKC) family","TKL: Tyrosine kinase-like","Casein kinase 1 (CK1) family","STE20 family","Protein kinase D (PKD) family","p38 subfamily","Non-receptor tyrosine kinases (nRTKs)","Delta subfamily",
"JNK subfamily","Receptor tyrosine kinases (RTKs)","RAF family","MSN subfamily","KHS subfamily","Src family","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Immune System",Disease,"Signal Transduction",Metabolism,"Cell Cycle","Cellular responses to external stimuli","Gene expression (Transcription)","Innate Immune System","Infectious disease","Signaling
 by GPCR","MAPK family signaling cascades","Biological oxidations",Mitotic,"Cellular responses to stress","Metabolism of lipids","Diseases of signal transduction by growth factor receptors and second 
messengers","RNA Polymerase II Transcription","Intracellular signaling by second messengers","Toll-like Receptor Cascades","HIV Infection","GPCR downstream signalling","MAPK1/MAPK3 signaling","Phase I
 - Functionalization of compounds","Mitotic G2-G2/M phases","Cellular Senescence","Sphingolipid metabolism","Signaling by WNT in cancer","Generic Transcription Pathway","PIP3 activates AKT signaling",
"Toll Like Receptor 5 (TLR5) Cascade","Host Interactions of HIV factors","G alpha (i) signalling events","G alpha (q) signalling events","RAF/MAP kinase cascade","Cytochrome P450 - arranged by substra
te type","G2/M Transition","Oxidative Stress Induced Senescence","Sphingolipid de novo biosynthesis","Signaling by AMER1 mutants","Transcriptional regulation by RUNX3","PTEN Regulation","MyD88 cascade
 initiated on plasma membrane","The role of Nef in HIV-1 replication and disease pathogenesis","Visual phototransduction","Gastrin-CREB signalling pathway via PKC and MAPK","Negative regulation of MAP
K pathway",Xenobiotics,"Centrosome maturation","Truncations of AMER1 destabilize the destruction complex","RUNX3 Regulates Immune Response and Cell Migration","Regulation of PTEN stability and activit
y","MAP kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","The phototransduction cascade","EGFR Transactivation by Gastrin","Negative 
feedback regulation of MAPK pathway","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","Aromatic amines can be N-hydroxylated or N-dealkylated 
by CYP1A2","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation",Inactivation,"recovery and regulation of the phototransduction cascade","Loss of Nlp from mitotic c
entrosomes","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK11,MAPK14,PTGS2}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"SB 239063",193551-21-2,193551212,SB239063,SB-239063,UNII-HII3DC8CPI,UNIIHII3DC8CPI,CHEMBL97162,HII3DC8CPI,CHEMBL4166018,CHEBI:90681,MFCD03792786,Kinome_3168,Kinome3168,Kinome-3168,"Kinome 3168",Tocr
is-1962,Tocris1962,cc-465,cc465,MLS006010690,SCHEMBL173595,SCHEMBL173596,CHEMBL256835,SCHEMBL4918359,SCHEMBL13933075,CHEBI:91347,"EMD 559404",1962,559404}

> <pdid>
PD013030

> <targets>
{"p38 MAPK","SB 239063"}

> <classes>
{}

> <pubchem_cids>
{5166}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 49  0  0  0  0            999 V2000
    7.7747   -7.5171    0.0000 C   0  0
    7.7822   -6.0171    0.0000 C   0  0
    6.4870   -5.2605    0.0000 N   0  0
    5.1842   -6.0040    0.0000 C   0  0
    5.1766   -7.5040    0.0000 C   0  0
    6.4719   -8.2606    0.0000 C   0  0
    6.4643   -9.7613    0.0000 N   0  0
    5.2484  -10.6165    0.0000 C   0  0
    3.7823  -10.2994    0.0000 C   0  0
    2.7746  -11.4104    0.0000 C   0  0
    3.2330  -12.8387    0.0000 C   0  0
    4.6991  -13.1559    0.0000 C   0  0
    5.7068  -12.0448    0.0000 C   0  0
    7.2060  -12.0504    0.0000 N   0  0
    7.6747  -10.6255    0.0000 C   0  0
    9.1002  -10.1587    0.0000 O   0  0
    6.4915   -3.7597    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
   -3.7124    4.0029    0.0000 N   0  0
   -3.1023    5.3733    0.0000 C   0  0
   -1.6105    5.2165    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14 15  1  0
 15  7  1  0
 15 16  2  0
  3 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 21 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
 31 32  1  0
 32 33  2  0
 33 24  1  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 39 34  1  0
 29 40  1  0
 40 41  1  0
 41 42  2  0
 42 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28867

> <plate>
Kinase v5-3

> <well>
I10

> <supplier_cmpd_name>
Akti-1/2

> <ctcr_id>
11960

> <supplier_cmpd_id>
S7776

> <smiles>
C1CN(CCC1n1c2ccccc2[nH]c1=O)Cc1ccc(cc1)c1nc2cc3c(cc2nc1c1ccccc1)[nH]cn3

> <pd_targets>
{AKT2,AKT3,AKT1,ACP1}

> <pathway_gtopdb>
{Enzyme,Kinase,Phosphatase,"Protein Kinase","Protein Phosphatase","AGC protein kinase group","Tyrosine protein phosphatase","AGC protein kinase AKT family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Akt (Protein kinase B","PKB) family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Signaling by Insulin receptor","Generic Transcription Pathway","Ins
ulin receptor signalling cascade","Transcriptional Regulation by TP53","IRS-mediated signalling","Regulation of TP53 Activity","PI3K Cascade","Regulation of TP53 Expression and Degradation","PKB-media
ted events","Regulation of TP53 Degradation","PDE3B signalling"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Akt inhibitor VIII",Akti-1/2,Akti1/2,612847-09-3,612847093,"Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2","Akt Inhibitor VIII, IsozymeSelective, Akti1/2",Akt-I-1/2,AktI1/2,"isozyme-selective, Akt
i-1/2","isozymeselective, Akti1/2","imidazoquinoxaline 16h",UNII-YX4CPQ6V6X,UNIIYX4CPQ6V6X,YX4CPQ6V6X,MLS003509084,MLS006010829,CHEMBL258844,GTPL5921,SC,T3346,"AKT inhibitor VIII"}

> <pdid>
PD012952

> <targets>
{Akt,Akt1,Akt2,Akt3,Apoptosis}

> <classes>
{Cytoskeletal Signaling,PI3K/Akt/mTOR signaling,Apoptosis,PI3K/Akt/mTOR}

> <pubchem_cids>
{135398501}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 38  0  0  0  0            999 V2000
    5.1983   -3.0012    0.0000 C   0  0
    5.1978   -4.5012    0.0000 O   0  0
    3.8985   -2.2508    0.0000 C   0  0
    2.5988   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.1905    2.6376    0.0000 C   0  0
   -2.1880    3.7544    0.0000 C   0  0
   -2.6518    5.1810    0.0000 C   0  0
   -1.6483    6.2959    0.0000 C   0  0
   -0.1810    5.9844    0.0000 C   0  0
    0.2828    4.5579    0.0000 C   0  0
   -0.7207    3.4429    0.0000 C   0  0
   -4.6589    2.9478    0.0000 N   0  0
   -5.1253    4.3743    0.0000 C   0  0
   -6.5925    4.6864    0.0000 C   0  0
   -7.0558    6.1131    0.0000 C   0  0
   -6.0520    7.2277    0.0000 C   0  0
   -4.5848    6.9156    0.0000 C   0  0
   -4.1215    5.4889    0.0000 C   0  0
   -6.5126    8.6561    0.0000 C   0  0
   -5.5066    9.7698    0.0000 N   0  0
   -5.9670   11.1974    0.0000 C   0  0
   -4.0400    9.4552    0.0000 C   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1065    0.0000    0.0000 O   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    6.4985   -2.2516    0.0000 N   0  0
    7.7983   -3.0020    0.0000 C   0  0
    9.0978   -2.2529    0.0000 C   0  0
  1  2  2  0
  1  3  1  0
  3  4  3  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 10 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 21 24  1  0
 24 25  1  0
 25 26  1  0
 25 27  1  0
  9 28  1  0
 28 29  2  0
 28 30  1  0
 30 31  1  0
 31  8  1  0
 31 32  2  0
 32  5  1  0
  1 33  1  0
 33 34  1  0
 34 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
28868

> <plate>
Kinase v5-3

> <well>
I12

> <supplier_cmpd_name>
BI-847325

> <ctcr_id>
11631

> <supplier_cmpd_id>
S7843

> <smiles>
C(=O)(C#Cc1ccc2/C(=C(\c3ccccc3)/Nc3ccc(cc3)CN(C)C)/C(=O)Nc2c1)NCC

> <pd_targets>
{AURKB-B,MAP2K1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","STE protein kinase group","Other protein kinase AUR family","STE protein kinase STE7 family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","STE7 family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by NTRKs","Signaling by NTRK1 (TRKA)","Signalling to ERKs","Prolonged ERK activation events","Frs2-mediated activation"}

> <broad_targets>
{AURKA,AURKB,AURKC,MAP2K1,MAP2K2}

> <broad_moa>
{"Aurora kinase inhibitor","MEK inhibitor"}

> <synonyms>
{I84732,1207293-36-4,1207293364,BI-847325,BI847325,hylpropiolamide,"BI 847325",5U5,SCHEMBL4081822,CHEMBL3699142,CHEMBL4303500,SCHEMBL10326049,BDBM142744,BCP15994,EX-A1727,EXA1727,NSC799360,s7843,AKOS0
30238788,ZINC143989489,ZINC143989696,ACN-037512,ACN037512,CCG-269395,CCG269395,CS-6291,CS6291,NSC-799360,SB2,T6785}

> <pdid>
PD017275

> <targets>
{MEK,"Aurora Kinase","Aurora A (Human)","Aurora B (Xenopus laevis)","Aurora C (Human)",MEK1,MEK2,Apoptosis}

> <classes>
{Cell Cycle/Checkpoint,MAPK,Chromatin/Epigenetic,Apoptosis,Cell Cycle/DNA Damage,Epigenetics,MAPK/ERK Pathway}

> <pubchem_cids>
{135567102}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  0  0            999 V2000
    5.1937   -3.0093    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    5.1912   -4.5090    0.0000 C   0  0
    3.8912   -5.2570    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.3408   -4.2142    0.0000 C   0  0
   -1.8408   -4.2089    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -6.4939    0.7411    0.0000 N   0  0
   -6.4894   -0.7597    0.0000 C   0  0
   -7.7846   -1.5163    0.0000 C   0  0
   -7.7770   -3.0163    0.0000 C   0  0
   -6.4742   -3.7597    0.0000 N   0  0
   -5.1790   -3.0032    0.0000 C   0  0
   -3.8762   -3.7466    0.0000 Cl  0  0
   -5.1866   -1.5032    0.0000 C   0  0
   -3.8967    0.7484    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 13  1  0
 11 16  2  3
 16  7  1  0
 10 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  3
 26 27  1  0
 27 28  1  0
 27 29  2  3
 29 23  1  0
 21 30  2  3
 30 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28871

> <plate>
Kinase v5-3

> <well>
I18

> <supplier_cmpd_name>
VPS34-IN1

> <ctcr_id>
12132

> <supplier_cmpd_id>
S7980

> <smiles>
CC(C)(O)CNC1=NC=C(C(CC2CC2)=N1)C1=CC=NC(NC2=CC=NC(Cl)=C2)=N1

> <pd_targets>
{PIK3C3}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases","Phosphatidylinositol 3-kinase family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by Insulin receptor","Insulin receptor signalling cascade","IRS-mediated signalling","PI3K Cascade"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{PS34IN,Vps34-IN-1,Vps34IN1,1383716-33-3,1383716333,VPS34-IN1,VPS34IN1,CHEMBL3913746,"Vps34IN1;VPS34 IN1",GTPL9378,SCHEMBL9957245,"example 16a (US8685993)",BCP25165,EX-A2444,EXA2444,BDBM50197067,s7980
,ZINC200552794,CCG-268956,CCG268956,CS-5249,CS5249,AC-32651,AC32651,AK547305,BS-15482,BS15482,HY-12795,HY12795,T7015}

> <pdid>
PD012810

> <targets>
{PI3K,Vps34}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{57404276}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 40  0  0  0  0            999 V2000
    7.8125   -5.9872    0.0000 C   0  0
    9.1087   -5.2323    0.0000 O   0  0
    7.8187   -7.4880    0.0000 C   0  0
    7.8242   -8.9880    0.0000 C   0  0
    6.5226   -8.2430    0.0000 C   0  0
    9.1204   -8.2335    0.0000 N   0  0
    6.5102   -5.2414    0.0000 N   0  0
    6.5040   -3.7405    0.0000 C   0  0
    5.2034   -2.9932    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    6.4978   -0.7405    0.0000 C   0  0
    7.7984   -1.4879    0.0000 C   0  0
    7.8015   -2.9878    0.0000 C   0  0
    3.8990   -0.7455    0.0000 S   0  0
    3.8964    0.7545    0.0000 O   0  0
    2.5988    0.0025    0.0000 O   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -5.1977   -2.9829    0.0000 O   0  0
   -5.1903   -1.4829    0.0000 C   0  0
   -0.0128   -6.0039    0.0000 Cl  0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
  1  2  2  0
  1  3  1  0
  3  4  1  0
  3  5  1  0
  3  6  1  0
  1  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 10 14  1  0
 14 15  2  0
 14 16  2  0
 14 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 29 31  1  0
 31 32  1  0
 26 33  1  0
 21 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28872

> <plate>
Kinase v5-3

> <well>
L08

> <supplier_cmpd_name>
Pilaralisib (XL147)

> <ctcr_id>
11405

> <supplier_cmpd_id>
S7645

> <smiles>
C(=O)(C(C)(C)N)Nc1cc(ccc1)S(=O)(=O)Nc1nc2c(nc1Nc1c(ccc(c1)OC)Cl)cccc2

> <pd_targets>
{PIK3CB,PIK3CA,PIK3CG,PIK3C3,PIK3CD,PRKDC,PIK3R1,PIK3R2,PIK3R3,PIK3R5}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidylinositol 3-kinase family","Phosphatidyl inositol 3' kinase-relat
ed kinases (PIKK) family","Other PIKK family kinases"}

> <pathway_reactome>
{"Signal Transduction",Disease,Metabolism,"Immune System","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lip
ids","Cytokine Signaling in Immune system","Innate Immune System","Signaling by Insulin receptor","Signaling by FGFR in disease","Phospholipid metabolism","Signaling by Interleukins","Cytosolic sensor
s of pathogen-associated DNA","Insulin receptor signalling cascade","Signaling by FGFR1 in disease","PI Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","STING mediated induction of host
 immune responses","IRS-mediated signalling","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membrane","Interleukin receptor SHC signaling","IRF3-mediated induction of type I IFN",
"PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants"}

> <broad_targets>
{}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{Pilaralisib,934526-89-3,934526893,XL-147,XL147,SAR-245408,SAR245408,"Pilaralisib (XL147)",UNII-60ES45KTMK,UNII60ES45KTMK,60ES45KTMK,"Pilaralisib (USAN:INN)","Pilaralisib, SAR245408",SCHEMBL189422,CHE
MBL3360203,SCHEMBL14921345,SCHEMBL16154579,EX-A196,EXA196,AMY10846,BCP15312,BDBM50197062,MFC,T2365}

> <pdid>
PD012456

> <targets>
{PI3K,PI3K¦Á,PI3K¦Â,PI3K¦Ã,PI3K¦Ä}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{56599306}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    2.5981    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 N   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.6003   -1.4978    0.0000 O   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -5.2007   -1.4909    0.0000 C   0  0
   -6.4972   -0.7365    0.0000 C   0  0
   -6.4920    0.7635    0.0000 C   0  0
   -5.1903    1.5090    0.0000 C   0  0
   -3.8939    0.7546    0.0000 C   0  0
   -7.7884    1.5180    0.0000 F   0  0
   -5.2059   -2.9909    0.0000 F   0  0
    3.8963    3.7531    0.0000 N   0  0
    3.8941    5.2539    0.0000 C   0  0
    5.1923    6.0070    0.0000 C   0  0
    5.1902    7.5079    0.0000 C   0  0
    6.4876    8.2605    0.0000 O   0  0
    2.5946    6.0048    0.0000 C   0  0
    2.5941    7.5056    0.0000 C   0  0
    1.2953    8.2560    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  2  1  0
 11 12  2  0
 10 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 15 21  1  0
  5 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 23 27  1  0
 27 28  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28873

> <plate>
Kinase v5-3

> <well>
K20

> <supplier_cmpd_name>
Pamapimod (R-1503, Ro4402257)

> <ctcr_id>
12375

> <supplier_cmpd_id>
S8125

> <smiles>
Cn1c2nc(ncc2cc(c1=O)Oc1c(cc(cc1)F)F)NC(CCO)CCO

> <pd_targets>
{MAPK10,MAPK14,NLK,CSNK1E,MAPK8,MAPK11,RPS6KA3,MAPK9,RPS6KA4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CK1 protein kinase group","AGC protein kinase group","CMGC protein kinase MAPK family","CK1 protein kinase CK1 family","AGC protein kinase 
RSK family","CMGC protein kinase JNK subfamily","CMGC protein kinase p38 subfamily","CMGC protein kinase nmo subfamily","AGC protein kinase RSK subfamily","AGC protein kinase MSK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","AGC: Containing PKA",PKG,"PKC families","Mitogen-activated protein kinases (MAP kinases)","Casei
n kinase 1 (CK1) family","RSK family","JNK subfamily","p38 subfamily","nmo subfamily","RSK subfamily","MSK subfamily"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Cell Cycle","Developmental Biology","Innate Immune System","Signaling by WNT",Mitotic,"Nervous system development","Toll-like Receptor Cascades","Beta-catenin i
ndependent WNT signaling","Mitotic G2-G2/M phases","Axon guidance","Toll Like Receptor 5 (TLR5) Cascade","Ca2+ pathway","G2/M Transition","L1CAM interactions","MyD88 cascade initiated on plasma membra
ne","Centrosome maturation","Recycling pathway of L1","MAP kinase activation","Loss of proteins required for interphase microtubule organization from the centrosome","MAPK targets/ Nuclear events medi
ated by MAP kinases","Loss of Nlp from mitotic centrosomes","Activation of the AP-1 family of transcription factors","CREB phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Pamapimod,449811-01-2,449811012,"RO 4402257",Ro4402257,UNII-8S2C9V11K4,UNII8S2C9V11K4,"Pamapimod (R-1503, Ro4402257)","Pamapimod (R1503, Ro4402257)",CHEMBL1090089,R1503,CHEBI:90685,8S2C9V11K4,Ro-4402
257,"Pamapimod (USAN:INN)",R-1503,PamapimodR-1503,PamapimodR1503,"Pamapimod (INN/USAN)","R 1503",GTPL9915,SCHEMBL3636,T6927}

> <pdid>
PD043657

> <targets>
{"p38 MAPK",p38¦Á,p38¦Â}

> <classes>
{MAPK}

> <pubchem_cids>
{16220188}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  0  0            999 V2000
    6.4995   -3.7432    0.0000 C   0  0
    7.7985   -2.9932    0.0000 C   0  0
    7.7985   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8994   -3.7478    0.0000 O   0  0
   -5.1981   -2.9955    0.0000 C   0  0
   -6.4997   -3.7409    0.0000 N   0  0
   -7.7962   -2.9865    0.0000 C   0  0
   -7.7910   -1.4865    0.0000 N   0  0
   -6.4894   -0.7410    0.0000 C   0  0
   -5.1929   -1.4954    0.0000 C   0  0
   -6.4811    0.7599    0.0000 C   0  0
   -5.1784    1.5035    0.0000 O   0  0
    9.0982   -0.7428    0.0000 C   0  0
   10.3977   -1.4919    0.0000 F   0  0
    9.0977    0.7572    0.0000 F   0  0
   10.3969    0.0079    0.0000 F   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 18 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 25 27  1  0
 27 28  1  0
  3 29  1  0
 29 30  1  0
 29 31  1  0
 29 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28874

> <plate>
Kinase v5-3

> <well>
K22

> <supplier_cmpd_name>
BFH772

> <ctcr_id>
12252

> <supplier_cmpd_id>
S8188

> <smiles>
c1cc(cc(c1)NC(=O)c1cccc2c1ccc(c2)Oc1ncnc(c1)CO)C(F)(F)F

> <pd_targets>
{KDR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","VEGFA-VEGFR2 Pathway","VEGFR2 mediated cell proliferation"}

> <broad_targets>
{}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{BFH772,890128-81-1,890128811,BFH-772,BFH-722,BFH722,UNII-T1IV236CVP,UNIIT1IV236CVP,T1IV236CVP,CHEMBL4080062,"BFH 772",SCHEMBL987715,BCP18910,EX-A1157,EXA1157,BDBM50270425,MFCD30534392,s8188,ZINC11497
6148,CCG-269115,CCG269115,CS-6044,CS6044,AC-32955,AC32955,AK685741,BS-17877,BS17877,HY-100419,HY100419,A16342,Q27289542,T3599}

> <pdid>
PD053576

> <targets>
{VEGFR,VEGFR2}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{24756034}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  1  0            999 V2000
    2.6018   -5.9994    0.0000 C   0  0
    3.9008   -5.2492    0.0000 O   0  0
    3.9014   -3.7484    0.0000 C   0  0
    2.6012   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    3.8967   -0.7484    0.0000 C   0  0
    5.1969   -1.4963    0.0000 C   0  0
    6.4939   -0.7411    0.0000 O   0  0
    6.4894    0.7589    0.0000 C   0  0
    5.1993   -2.9963    0.0000 C   0  0
    6.4987   -3.7473    0.0000 O   0  0
    6.4990   -5.2473    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    1.2990    0.7500    0.0000 C   0  0  1  0  0  0
    0.0000    1.5000    0.0000 C   0  0  2  0  0  0
    0.3114    2.9665    0.0000 C   0  0
    1.8032    3.1233    0.0000 O   0  0
    2.4133    1.7530    0.0000 C   0  0
    3.8805    1.4410    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0  1  0  0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.7124   -4.0030    0.0000 O   0  0
   -3.1022   -5.3733    0.0000 C   0  0
   -1.6105   -5.2165    0.0000 O   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  7 10  2  0
 10  3  1  0
 10 11  1  0
 11 12  1  0
 13  5  1  6
 13 14  1  0
 14 15  1  0
 15 16  1  1
 16 17  1  0
 17 18  1  0
 14 18  1  1
 18 19  2  0
 15 20  1  0
 20 21  1  6
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 24  2  0
 28 29  1  0
 29 30  2  0
 30 13  1  0
 30 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28875

> <plate>
Kinase v5-3

> <well>
K04

> <supplier_cmpd_name>
Picropodophyllin (PPP)

> <ctcr_id>
742

> <supplier_cmpd_id>
S7668

> <smiles>
COc1cc(cc(OC)c1OC)[C@H]2[C@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24

> <pd_targets>
{TUBB2B,TUBA1A,LMNA,HIF1A,CYP3A4,TUBA1B,TUBA1C,TUBA3C,TUBA3E,TUBA4A,TUBB,TUBB1,TUBB2A,TUBB3,TUBB4A,TUBB4B,TUBB6,TUBB8,E2,LEF,NR3C1,CYP2C19,NR0B1,CYP2C9,TUBB5,TOP2A,IGF1R,GMNN,NFO,NPSR1,MTOR}

> <pathway_gtopdb>
{"Structural protein","Other nuclear protein","Transcription factor",Enzyme,"Cytochrome P450",Protease,"Nuclear receptor",Isomerase,"Cytochrome P450 family 3","Metallo protease","Nuclear hormone recep
tor subfamily 3","Cytochrome P450 family 2","Nuclear hormone receptor subfamily 0","Cytochrome P450 family 3A","Metallo protease MAE clan","Nuclear hormone receptor subfamily 3 group C","Cytochrome P4
50 family 2C","Nuclear hormone receptor subfamily 0 group B","Cytochrome P450 3A4","Metallo protease M34 family","Nuclear hormone receptor subfamily 3 group C member 1","Cytochrome P450 2C19","Nuclear
 hormone receptor subfamily 0 group B member 1","Cytochrome P450 2C9",Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase InsR family","Unclassified protein","Membrane receptor"
,Hydrolase,"Family A G protein-coupled receptor","Peptide receptor (family A GPCR)","Short peptide receptor (family A GPCR)","Atypical protein kinase group","Neuropeptide receptor","Atypical protein k
inase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets","Cytochrome P450","Nuclear hormone receptors",Tubulins,"DNA topoisomerases","CYP3 family","Steroid hormone receptors","CYP2 family: drug metabolising subset"
,"0B. DAX-like receptors","3C. 3-Ketosteroid receptors","Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type II RTKs: Insulin receptor family","G pro
tein-coupled receptors","Kinases (EC 2.7.x.x)","Neuropeptide S receptor",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{"Cell Cycle","Cellular responses to external stimuli",Metabolism,Disease,"Gene expression (Transcription)",Mitotic,"Cellular responses to stress","Metabolism of lipids","Infectious disease","RNA Poly
merase II Transcription","Biological oxidations","M Phase","Cellular response to hypoxia","Biosynthesis of specialized proresolving mediators (SPMs)","Uptake and actions of bacterial toxins","Generic 
Transcription Pathway","Mitotic G2-G2/M phases","Phase I - Functionalization of compounds","Mitotic G1 phase and G1/S transition","Mitotic Metaphase and Anaphase","Oxygen-dependent proline hydroxylati
on of Hypoxia-inducible Factor Alpha","Biosynthesis of DHA-derived SPMs","Uptake and function of anthrax toxins","FOXO-mediated transcription","G2/M Transition","Cytochrome P450 - arranged by substrat
e type","Nuclear Receptor transcription pathway","G0 and Early G1","Mitotic Anaphase","Biosynthesis of maresins","FOXO-mediated transcription of oxidative stress","metabolic and neuronal genes","Centr
osome maturation",Xenobiotics,"Transcription of E2F targets under negative control by DREAM complex","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SPMs","Loss of proteins required f
or interphase microtubule organization from the centrosome","CYP2E1 reactions","Sealing of the nuclear envelope (NE) by ESCRT-III","Initiation of Nuclear Envelope (NE) Reformation","Loss of Nlp from m
itotic centrosomes","Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","IGF1R signaling cascade","IRS-related events tri
ggered by IGF1R","Leishmania infection","G1/S Transition","Leishmania parasite growth and survival","Transcriptional Regulation by TP53","Activation of the pre-replicative complex","Anti-inflammatory 
response favouring Leishmania parasite infection","Regulation of TP53 Activity","ADORA2B mediated anti-inflammatory cytokines production","Regulation of TP53 Expression and Degradation","Regulation of
 TP53 Degradation"}

> <broad_targets>
{IGF1R,TOP2A,TUBA4A,TUBB}

> <broad_moa>
{"microtubule inhibitor","tubulin polymerization inhibitor"}

> <synonyms>
{Picropodophyllin,Picropodophyllotoxin,477-47-4,477474,AXL1717,"Picropodophyllin (PPP)",(-)PPP,()PPP,"IGF-1R Inhibitor, PPP","IGF1R Inhibitor, PPP",UNII-0F35AOI227,UNII0F35AOI227,"AXL1717 (Picropodoph
yllotoxin)",NSC36407,CHEBI:75251,0F35AOI227,AXL-1717,NSC-36407,"cyclolignan PPP",picro,T6943,T3S0027,T1121,1504410,Podophyllotoxin,PICROPODOPHYLLOTOXIN}

> <pdid>
PD000047

> <targets>
{IGF-1R,Apoptosis}

> <classes>
{antineoplastic,10% cytotoxicity of podophyllotoxin,Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{72435}

$$$$
UTKinase_V5
  SciTegic11012413002D

 43 47  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988    1.5004    0.0000 S   0  0
   -2.5998    3.0004    0.0000 O   0  0
   -3.8976    0.7500    0.0000 O   0  0
   -3.8982    2.2498    0.0000 O   0  0
   15.6663    3.9125    0.0000 C   0  0
   15.3585    2.4444    0.0000 N   0  0
   16.3586    1.3265    0.0000 C   0  0
   15.6045    0.0299    0.0000 C   0  0
   14.1383    0.3464    0.0000 N   0  0
   14.0051    1.8277    0.0000 C   0  0
   12.7066    2.5801    0.0000 C   0  0
   12.7090    4.0801    0.0000 C   0  0
   11.4111    4.8322    0.0000 C   0  0
   10.1108    4.0843    0.0000 N   0  0
   10.1085    2.5842    0.0000 C   0  0
   11.4064    1.8322    0.0000 C   0  0
    8.8111    4.8347    0.0000 C   0  0
    8.8111    6.3347    0.0000 N   0  0
    7.5120    7.0847    0.0000 C   0  0
    6.2130    6.3347    0.0000 N   0  0
    6.2130    4.8347    0.0000 C   0  0
    7.5121    4.0847    0.0000 C   0  0
    7.2006    2.6182    0.0000 C   0  0
    5.7088    2.4614    0.0000 N   0  0
    5.0987    3.8317    0.0000 N   0  0
   16.2106   -1.3431    0.0000 C   0  0
   17.6807   -1.6146    0.0000 C   0  0
   18.1815   -3.0285    0.0000 C   0  0
   17.2074   -4.1692    0.0000 C   0  0
   15.7325   -3.8959    0.0000 C   0  0
   15.2317   -2.4819    0.0000 C   0  0
   17.7082   -5.5831    0.0000 F   0  0
   19.6572   -3.3019    0.0000 C   0  0
   20.6321   -2.1619    0.0000 F   0  0
   20.1576   -4.7160    0.0000 F   0  0
   21.1320   -3.5759    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  2  0
  8 11  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 13  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
 21 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 28  1  0
 15 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 37  1  0
 37 38  2  0
 38 33  1  0
 36 39  1  0
 35 40  1  0
 40 41  1  0
 40 42  1  0
 40 43  1  0
M  END
> <name>
UTKinase_V5

> <id>
28876

> <plate>
Kinase v5-3

> <well>
K06

> <supplier_cmpd_name>
LY2584702 Tosylate

> <ctcr_id>
12793

> <supplier_cmpd_id>
S7704

> <smiles>
Cc1ccc(cc1)S(=O)(=O)O.Cn1cc(nc1C1CCN(CC1)c1ncnc2c1cn[nH]2)c1cc(c(cc1)F)C(F)(F)F

> <pd_targets>
{RPS6KB1,RPS6KA1,RPS6KA2,RPS6KA3,RPS6KA4,RPS6KA5,RPS6KA6,RPS6KB2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase RSK family","AGC protein kinase p70 subfamily","AGC protein kinase MSK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","RSK family","p70 subfamily"}

> <pathway_reactome>
{"Signal Transduction","MTOR signalling","mTORC1-mediated signalling"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{1082949-68-5,1082949685,"LY2584702 tosylate","LY-2584702 tosylate salt","LY2584702 tosylate salt","LY-2584702 (tosylate salt)","LY2584702 (tosylate salt)","1082949-68-5 (tosylate)","1082949685 (tosyl
ate)",LYS6K2,LY2584702.TsOH,"LY 2584702 tosylate","LY-2584702 Tosylate","LY2584702 Tosylate","LY-2584702 free base","LY2584702 free base",SCH,T1746}

> <pdid>
PD038909

> <targets>
{"S6 Kinase","p70 S6K","Ribosomal S6 Kinase (RSK)"}

> <classes>
{PI3K/Akt/mTOR signaling,MAPK/ERK Pathway}

> <pubchem_cids>
{46205871}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  0  0            999 V2000
   13.0254   -3.6030    0.0000 C   0  0
   13.9064   -2.3890    0.0000 C   0  0
   15.3982   -2.5453    0.0000 C   0  0
   14.5171   -3.7590    0.0000 C   0  0
   13.2970   -1.0202    0.0000 C   0  0
   11.8298   -0.7084    0.0000 C   0  0
   11.6919    0.7725    0.0000 C   0  0
   10.3906    1.5203    0.0000 N   0  0
    9.0920    0.7681    0.0000 C   0  0
    9.0945   -0.7319    0.0000 O   0  0
    7.7907    1.5158    0.0000 N   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 O   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    5.1852    3.0091    0.0000 F   0  0
   13.0433    1.3935    0.0000 N   0  0
   14.0470    0.2788    0.0000 N   0  0
   13.3466    2.8633    0.0000 C   0  0
   12.3117    3.9418    0.0000 C   0  0
   12.7305    5.3821    0.0000 C   0  0
   14.1873    5.7395    0.0000 C   0  0
   15.2252    4.6566    0.0000 C   0  0
   14.8064    3.2163    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 27 17  1  0
 27 21  2  0
 15 28  1  0
 28 29  2  0
 29 12  1  0
 29 30  1  0
  7 31  1  0
 31 32  1  0
 32  5  2  0
 31 33  1  0
 33 34  2  0
 34 35  1  0
 35 36  2  0
 36 37  1  0
 37 38  2  0
 38 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28877

> <plate>
Kinase v5-3

> <well>
K08

> <supplier_cmpd_name>
CCT196969

> <ctcr_id>
12353

> <supplier_cmpd_id>
S7743

> <smiles>
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1ccccc1

> <pd_targets>
{BRAF,RAF1,LCK,SRC}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TK protein kinase group","TKL protein kinase RAF family","Tyrosine protein kinase Src family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","RAF family","Non-receptor tyrosine kinases (nRTKs)","Src family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","Infectious disease","Signaling by NTRKs","MAPK1/MAPK3 signaling","HIV Infection","Signaling by
 NTRK1 (TRKA)","RAF/MAP kinase cascade","Host Interactions of HIV factors","Signalling to ERKs","Negative regulation of MAPK pathway","The role of Nef in HIV-1 replication and disease pathogenesis","P
rolonged ERK activation events","Negative feedback regulation of MAPK pathway","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","Signalling to RAS","ARM
S-mediated activation","Nef Mediated CD4 Down-regulation","p38MAPK events"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MFCD28384201,CCT196969,1163719-56-9,1163719569,CHEMBL4216588,CCT-196969,GTPL9815,SCHEMBL3761639,BCP19551,EX-A1598,EXA1598,BDBM50457449,s7743,ZINC43205799,AKOS027422849,CCG-269799,CCG269799,CS-6229,CS
6229,HY-12846,HY12846,T4133}

> <pdid>
PD063586

> <targets>
{Raf,Src,C-RAF}

> <classes>
{MAPK,Angiogenesis}

> <pubchem_cids>
{42628843}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  0  0            999 V2000
    7.3535    1.3069    0.0000 C   0  0
    5.8535    1.3037    0.0000 O   0  0
    5.1051    0.0028    0.0000 C   0  0
    4.6724   -1.3659    0.0000 C   0  0
    6.1220   -1.7517    0.0000 O   0  0
    6.5078   -0.3021    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 C   0  0
    3.1882   -2.6401    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.7248    1.2135    0.0000 S   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 N   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -6.4924   -3.7566    0.0000 N   0  0
   -3.8943   -3.7525    0.0000 N   0  0
   -2.5964   -3.0004    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  3  1  0
  3  7  1  0
  7  8  2  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 11 12  1  0
 12  7  1  0
 11 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 10  1  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 22 23  2  0
 23 17  1  0
 13 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28878

> <plate>
Kinase v5-3

> <well>
K10

> <supplier_cmpd_name>
GNE-317

> <ctcr_id>
12220

> <supplier_cmpd_id>
S7798

> <smiles>
COC1(COC1)c1c(C)c2c(s1)c(nc(n2)c1cnc(N)nc1)N1CCOCC1

> <pd_targets>
{MTOR,PIK3CA}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Lipid modifying kinases","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","FRAP subfami
ly"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,"RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","Signali
ng by FGFR in disease","Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","Regulation of TP53 Activity","FGFR1 mutant receptor activation","Regulation of TP53 Expression and Degradat
ion","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NE31,GNE-317,GNE317,1394076-92-6,1394076926,CHEMBL2178608,SCHEMBL19183441,"GNE 317","GNE317; GNE 317",BCP23939,EX-A1558,EXA1558,BDBM50398399,s7798,ZINC72316319,CCG-268819,CCG268819,CS-3961,CS3961,NCG
C00481572-02,NCGC0048157202,BS-15486,BS15486,HY-12763,HY12763,B4991,A13992,T6845}

> <pdid>
PD012812

> <targets>
{PI3K,PI3K/mTOR,mTOR}

> <classes>
{PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR}

> <pubchem_cids>
{70676303}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
    2.5569  -12.0048    0.0000 C   0  0
    2.5644  -10.5048    0.0000 N   0  0
    3.8672   -9.7614    0.0000 C   0  0
    3.8748   -8.2614    0.0000 C   0  0
    2.5795   -7.5047    0.0000 N   0  0
    1.2767   -8.2483    0.0000 C   0  0
    1.2692   -9.7483    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.4133    1.7530    0.0000 C   0  0
   -3.8805    1.4410    0.0000 C   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -0.3115    2.9665    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -6.4994   -0.7589    0.0000 C   0  0
   -7.7969   -1.5132    0.0000 C   0  0
   -9.0936   -2.2671    0.0000 N   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
   -0.0133   -5.9950    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 17 19  2  0
 19 20  1  0
 20 15  1  0
 16 21  1  0
 21 22  2  0
 22 13  1  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  3  0
 25 29  2  0
 29 30  1  0
 30 31  2  0
 31 23  1  0
 11 32  1  0
 32 33  2  0
 33  8  1  0
 33 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28879

> <plate>
Kinase v5-3

> <well>
K12

> <supplier_cmpd_name>
SGI-7079

> <ctcr_id>
11978

> <supplier_cmpd_id>
S7847

> <smiles>
CN1CCN(CC1)c1ccc(Nc2nc3c(c(C)c[nH]3)c(n2)c2cc(CC#N)ccc2)cc1F

> <pd_targets>
{AXL}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Axl family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","VEGFA-VEGFR2 Pathway"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{GI707,SGI-7079,SGI7079,1239875-86-5,1239875865,CHEMBL3809908,SCHEMBL3032802,BCP21014,EX-A1513,EXA1513,"SGI 7079; SGI707",BDBM50172076,s7847,ZINC143157631,ACN-052936,ACN052936,CCG-269290,CCG269290,CS-
5607,CS5607,AC-31429,AC31429,HY-12964,HY12964,LS-15137,LS15137,DS-002524,DS002524,T6982}

> <pdid>
PD071555

> <targets>
{VEGFR,Met,RET,FLT3,Yes,AXL,Mer,"TAM Receptor"}

> <classes>
{Angiogenesis,Apoptosis,Tyrosine Kinase/Adaptors,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{46870258}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
   -2.6933   -6.3162    0.0000 C   0  0
   -1.2256   -6.6258    0.0000 C   0  0
   -0.7603   -8.0518    0.0000 O   0  0
   -0.2234   -5.5086    0.0000 O   0  0
   -0.6890   -4.0818    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    4.0417   -4.4401    0.0000 C   0  0
    4.9463   -3.2436    0.0000 O   0  0
    4.4672   -5.8785    0.0000 N   0  0
    3.2312   -6.7270    0.0000 C   0  0
    3.0348   -8.2141    0.0000 C   0  0
    1.6487   -8.7875    0.0000 C   0  0
    1.4524  -10.2746    0.0000 Br  0  0
    0.4591   -7.8739    0.0000 C   0  0
    0.6554   -6.3869    0.0000 C   0  0
    2.0415   -5.8134    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  6  1  0
 14  9  1  0
  7 15  2  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 21 23  2  0
 23 24  1  0
 24 25  2  0
 25 15  1  0
 25 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28880

> <plate>
Kinase v5-3

> <well>
K14

> <supplier_cmpd_name>
BIO-acetoxime

> <ctcr_id>
7754

> <supplier_cmpd_id>
S7915

> <smiles>
CC(=O)O\N=C1/C(Nc2ccccc12)=C3/C(=O)Nc4cc(Br)ccc34

> <pd_targets>
{GSK3A,GSK3B,CCNB1,CCNB2,CCNB3,CDK1,AHR,CDK5,CDK5R1}

> <pathway_gtopdb>
{Enzyme,"Transcription factor",Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase GSK family","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily"}

> <pathway_chembl>
{"Other protein targets","Aryl hydrocarbon receptor"}

> <pathway_reactome>
{Metabolism,"Biological oxidations","Phase I - Functionalization of compounds","Cytochrome P450 - arranged by substrate type","Endogenous sterols"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{IOACETOXIM,BIO-Acetoxime,BIOAcetoxime,667463-85-6,667463856,"indirubin deriv. 8a","BIO-acetoxime (GSK-3 Inhibitor X)","BIOacetoxime (GSK3 Inhibitor X)",740841-15-0,740841150,"(2Z,3E)-3-(acetoxyimino)
-6'-bromo-(2,3'-biindolinylidene)-2'-one","(2Z,3E)3(acetoxyimino)6'bromo(2,3'biindolinylidene)2'one",6-BROMOINDIRUBIN-3'-ACETOXIME,6BROMOINDIRUBIN3'ACETOXIME,"6-bromoindirubin-3 -acetoxime","6bromoind
irubin3 acetoxime",BDBM7402,CHEMBL4,"EMD 361551",361551}

> <pdid>
PD015697

> <targets>
{GSK-3,Apoptosis,HSV}

> <classes>
{Anti-infection,Apoptosis,PI3K/Akt/mTOR,Stem Cell/Wnt}

> <pubchem_cids>
{135398521}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 36  0  0  0  0            999 V2000
    4.6580    2.9476    0.0000 C   0  0
    3.1904    2.6376    0.0000 C   0  0
    2.1885    3.7539    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 N   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -0.0079   -6.0003    0.0000 C   0  0
   -0.0080   -7.5003    0.0000 C   0  0
   -1.3070   -8.2503    0.0000 C   0  0
   -2.6060   -7.5003    0.0000 C   0  0
   -2.6060   -6.0003    0.0000 C   0  0
   -3.9057   -5.2499    0.0000 N   0  0
   -4.0459   -3.7693    0.0000 N   0  0
   -5.5136   -3.4597    0.0000 C   0  0
   -6.2616   -4.7599    0.0000 C   0  0
   -5.2561   -5.8731    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  4  8  2  3
  8  7  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 12  1  0
 10 18  1  0
 18 19  2  3
 19  7  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  3
 23 24  1  0
 24 25  2  3
 25 26  1  0
 26 27  2  3
 27 22  1  0
 27 28  1  0
 28 29  1  0
 29 30  2  3
 30 31  1  0
 31 32  2  3
 32 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28882

> <plate>
Kinase v5-3

> <well>
K18

> <supplier_cmpd_name>
LDC4297 (LDC044297)

> <ctcr_id>
11658

> <supplier_cmpd_id>
S7992

> <smiles>
CC(C)C(C=NN12)=C1N=C(OC3CNCCC3)N=C2NCC4=CC=CC=C4N5N=CC=C5

> <pd_targets>
{CDK2,CDK1,CDK9,CDK7}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase CDK7 subfami
ly"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Cyclin-dependent kinase (CDK) family","CDK1 subfamily","CDK9 subfamily","CDK7 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle",Disease,"RNA Polymerase II Transcription",Mitotic,"Infectious disease","Generic Transcription Pathway","Regulation of mitotic cell cycle","HIV Infection
","Transcriptional Regulation by TP53","APC/C-mediated degradation of cell cycle proteins","HIV Life Cycle","Regulation of TP53 Activity","Activation of APC/C and APC/C:Cdc20 mediated degradation of m
itotic proteins","Late Phase of HIV Life Cycle","Regulation of TP53 Expression and Degradation","APC/C:Cdc20 mediated degradation of mitotic proteins","Transcription of the HIV genome","Regulation of 
TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","HIV Transcription Elongation","Cdc20:Phospho-APC/C mediated degradation of 
Cyclin A","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{LDC4297,1453834-21-3,1453834213,LDC-4297,CHEMBL4562323,"LDC 4297","LDC4297 (LDC044297)",SCHEMBL15224676,CHEBI:144671,BCP20371,EX-A2533,EXA2533,BDBM50526793,LCD044297,s7992,"LDC 4297;LDC-4297","LDC 42
97;LDC4297",ACN-045522,ACN045522,CCG-269044,CCG269044,CS-6871,CS6871,AK688998,BS-15141,BS15141,HY-12653,HY12653,T4051}

> <pdid>
PD063673

> <targets>
{CDK,CDK7,HSV}

> <classes>
{Cell Cycle/Checkpoint,Anti-infection,Cell Cycle/DNA Damage}

> <pubchem_cids>
{78161839}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2990   -5.2500    0.0000 N   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2121    3.8625    0.0000 C   0  0
    0.7463    5.2884    0.0000 C   0  0
   -0.7537    5.2860    0.0000 N   0  0
   -1.2149    3.8587    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  2  3
  9 10  1  0
  9 11  1  0
 11 12  2  3
 12 13  1  0
 12 14  1  0
 14 15  2  3
 15  3  1  0
 15  8  1  0
  6 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28883

> <plate>
Kinase v5-3

> <well>
N08

> <supplier_cmpd_name>
Voxtalisib (XL765, SAR245409)

> <ctcr_id>
12033

> <supplier_cmpd_id>
S7646

> <smiles>
CCN1C(=O)C(=CC2=C(C)N=C(N)N=C12)C1=CC=NN1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{voxtalisib,934493-76-2,934493762,SAR245409,UNII-CVL1685GPH,UNIICVL1685GPH,"Voxtalisib (XL765, SAR245409)",CVL1685GPH,"2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido(2,3-d)pyrimidinone","2amino
8ethyl4methyl6(1Hpyrazol5yl)7pyrido(2,3d)pyrimidinone","2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido(2,3-d)pyrimidin-7-one","2amino8ethyl4methyl6(1Hpyrazol5yl)pyrido(2,3d)pyrimidin7one",V,T7014,
Voxtalisib}

> <pdid>

> <targets>
{mTOR,PI3K,DNA-PK,PI3K¦Á,PI3K¦Â,PI3K¦Ã,PI3K¦Ä}

> <classes>
{DNA Damage/DNA Repair,PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR}

> <pubchem_cids>
{16123056}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 33  0  0  1  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0  1  0  0  0
   -3.8971    3.7500    0.0000 O   0  0
   -5.1962    3.0000    0.0000 C   0  0
   -5.1962    1.5000    0.0000 C   0  0
   -6.4952    0.7500    0.0000 C   0  0
   -7.7942    1.4999    0.0000 C   0  0
   -7.7943    2.9999    0.0000 C   0  0
   -9.0933    3.7499    0.0000 O   0  0
   -9.0933    5.2499    0.0000 C   0  0
  -10.3743    4.4695    0.0000 C   0  0
   -9.0581    6.7495    0.0000 C   0  0
   -7.7943    5.9999    0.0000 C   0  0
   -6.4952    5.2500    0.0000 C   0  0
   -6.4952    3.7500    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981    1.5000    0.0000 C   0  0  1  0  0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  8  7  1  6
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 16 18  1  0
 16 19  1  0
 19 20  2  3
 20 21  1  0
 21 10  1  0
 21 14  2  0
 11 22  1  0
 22 23  2  0
 24 22  1  6
 24  8  1  0
 24 25  1  0
 25  5  2  0
 25 26  1  0
 26 27  2  0
 27  3  1  0
 27 28  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28884

> <plate>
Kinase v5-3

> <well>
M20

> <supplier_cmpd_name>
Deguelin

> <ctcr_id>
3741

> <supplier_cmpd_id>
S8132

> <smiles>
COc1cc2OC[C@H]3Oc4c(ccc5OC(C)(C)C=Cc45)C(=O)[C@H]3c2cc1OC

> <pd_targets>
{CYP2C19,TSHR,CYP2D6,HSP90AA1,MAPT,TP53,CYP3A4,RORC,FFP,LEF,CYP1A2}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Other cytosolic protein","Transcription factor","Cytochrome P450","Family A G protein-coupled receptor",Protease,"Nuclear receptor",Transferase,"Cytochrome P450 family 2",
"Peptide receptor (family A GPCR)","Cysteine protease","Cytochrome P450 family 3","Nuclear hormone receptor subfamily 1","Metallo protease","Cytochrome P450 family 1","Cytochrome P450 family 2C","Glyc
ohormone receptor","Cytochrome P450 family 2D","Cysteine protease CA clan","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 1 group F","Metallo protease MAE clan","Cytochrome P450 famil
y 1A","Cytochrome P450 2C19","Cytochrome P450 2D6","Cysteine protease C1A family","Cytochrome P450 3A4","Nuclear hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Cytochrom
e P450 1A1"}

> <pathway_chembl>
{Enzymes,Receptors,"Other protein targets","Cytochrome P450","G protein-coupled receptors","Heat shock proteins","Nuclear hormone receptors","CYP2 family: drug metabolising subset","Glycoprotein hormo
ne receptors","CYP3 family","1F. Retinoic acid-related orphans","CYP1 family"}

> <pathway_reactome>
{Metabolism,Disease,"Cell Cycle","Neuronal System","Gene expression (Transcription)","Biological oxidations","Infectious disease",Mitotic,"Transmission across Chemical Synapses","Cell Cycle Checkpoint
s","Metabolism of lipids","RNA Polymerase II Transcription","Phase I - Functionalization of compounds","Leishmania infection","Mitotic G2-G2/M phases","Neurotransmitter receptors and postsynaptic sign
al transmission","G1/S DNA Damage Checkpoints","Biosynthesis of specialized proresolving mediators (SPMs)","Generic Transcription Pathway","Uptake and actions of bacterial toxins","Cytochrome P450 - a
rranged by substrate type","Leishmania parasite growth and survival","G2/M Transition","Activation of NMDA receptors and postsynaptic events","p53-Dependent G1/S DNA damage checkpoint","Biosynthesis o
f DHA-derived SPMs","Transcriptional regulation by RUNX3","Uptake and function of anthrax toxins",Xenobiotics,"Anti-inflammatory response favouring Leishmania parasite infection","Centrosome maturatio
n","Post NMDA receptor activation events","p53-Dependent G1 DNA Damage Response","Biosynthesis of maresins","RUNX3 Regulates Immune Response and Cell Migration","CYP2E1 reactions","ADORA2B mediated an
ti-inflammatory cytokines production","Loss of proteins required for interphase microtubule organization from the centrosome","Activation of AMPK downstream of NMDARs","Stabilization of p53","Biosynth
esis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Loss of Nlp from mitotic centrosomes","Autodegradation of the E3 ubiquitin ligase COP1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Deguelin,522-17-8,522178,(-)-Deguelin,()Deguelin,(-)-cis-deguelin,()cisdeguelin,DEGUELIN(-),DEGUELIN(),UNII-K5Z93K66IE,UNIIK5Z93K66IE,CHEBI:4357,K5Z93K66IE,MFCD01740600,C23H22O6,SR-01000597503,SR0100
0597503,"CCRIS 8104",Deguelin/,"(-)-Deguelin, Mundulea sericea","()Deguelin, Mundulea sericea",Spectrum_001044,Spectrum001044,Spectrum-001044,"Spectrum 001044",Tocris-1770,Tocris1770,Spectrum2_000298,
Spectrum2000298,Spectrum2-000298,"Spectrum2 000298",Spectru,T6817,201138,DEGUELIN}

> <pdid>
PD002195

> <targets>
{Akt,PI3K,AKT,Apoptosis,Autophagy}

> <classes>
{antineoplastic,antiviral,insecticide,Apoptosis,Autophagy,PI3K/Akt/mTOR}

> <pubchem_cids>
{107935}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 34  0  0  0  0            999 V2000
    3.8976   -0.7553    0.0000 O   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 C   0  0
    1.2959    5.2508    0.0000 O   0  0
   -0.0049    5.9994    0.0000 C   0  0
   -0.0102    7.4994    0.0000 N   0  0
   -1.3118    8.2449    0.0000 C   0  0
   -1.3170    9.7449    0.0000 N   0  0
   -2.6083    7.4904    0.0000 N   0  0
   -2.6031    5.9904    0.0000 C   0  0
   -1.3014    5.2449    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    3.8933   -3.7570    0.0000 C   0  0
    3.8934   -5.2570    0.0000 C   0  0
    5.1924   -6.0070    0.0000 C   0  0
    6.4915   -5.2571    0.0000 C   0  0
    6.4915   -3.7571    0.0000 C   0  0
    7.7913   -3.0067    0.0000 C   0  0
    9.0908   -3.7559    0.0000 F   0  0
    7.7908   -1.5067    0.0000 F   0  0
    9.0900   -2.2561    0.0000 F   0  0
    5.1925   -3.0070    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  2  0
 15  9  1  0
  7 16  2  0
 16 17  1  0
 17  4  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20  3  1  0
  2 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 27 29  1  0
 27 30  1  0
 26 31  2  0
 31 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28885

> <plate>
Kinase v5-3

> <well>
M22

> <supplier_cmpd_name>
BAW2881 (NVP-BAW2881)

> <ctcr_id>
12249

> <supplier_cmpd_id>
S8189

> <smiles>
O=C(c1c2ccc(Oc3nc(N)ncc3)cc2ccc1)Nc1cccc(C(F)(F)F)c1

> <pd_targets>
{KDR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","VEGFA-VEGFR2 Pathway","VEGFR2 mediated cell proliferation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{BAW2881,861875-60-7,861875607,NVP-BAW2881,NVPBAW2881,CHEMBL4104297,6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide,6((2aminopyrimidin4yl)oxy)N(3(trifluoromethyl)phenyl)1nap
hthamide,"BAW2881 (NVP-BAW2881)","BAW2881 (NVPBAW2881)","NVP BAW2881",SCHEMBL2433509,BCP17232,EX-A1156,EXA1156,BDBM50270439,MFCD30343850,s8189,ZINC34865030,AKOS032945,T3641}

> <pdid>
PD044593

> <targets>
{VEGFR,Raf,c-RET,c-Abl,"B-Raf (V599E)",C-Raf-1,hVEGFR2}

> <classes>
{Angiogenesis,MAPK,"Cytoskeletal Signaling","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{16004702}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  1  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -5.2060    2.9909    0.0000 Cl  0  0
   -7.7884   -1.5181    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2122   -3.8625    0.0000 C   0  0
   -0.7464   -5.2884    0.0000 C   0  0
   -1.6226   -6.5037    0.0000 C   0  0
   -3.1149   -6.3519    0.0000 O   0  0
   -1.0080   -7.8729    0.0000 N   0  0
   -1.8857   -9.0903    0.0000 C   0  0  2  0  0  0
   -3.3785   -8.9354    0.0000 C   0  0
   -3.9912   -7.5662    0.0000 O   0  0
   -1.2711  -10.4596    0.0000 C   0  0
   -2.1465  -11.6776    0.0000 C   0  0
   -1.5295  -13.0448    0.0000 C   0  0
   -0.0369  -13.1940    0.0000 C   0  0
    0.8386  -11.9761    0.0000 C   0  0
    0.2215  -10.6089    0.0000 C   0  0
    2.3311  -12.1253    0.0000 Cl  0  0
    0.7536   -5.2860    0.0000 N   0  0
    1.2149   -3.8587    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 12 13  1  0
 10 14  1  0
  5 15  1  0
 15 16  2  0
 16  2  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 23 22  1  1
 23 24  1  0
 24 25  1  0
 23 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
 30 32  1  0
 19 33  1  0
 33 34  1  0
 34 17  2  0
M  END
> <name>
UTKinase_V5

> <id>
28887

> <plate>
Kinase v5-3

> <well>
M06

> <supplier_cmpd_name>
VX-11e

> <ctcr_id>
11476

> <supplier_cmpd_id>
S7709

> <smiles>
Cc1cnc(Nc2ccc(cc2Cl)F)nc1c1cc(C(=O)N[C@H](CO)c2cccc(c2)Cl)[nH]c1

> <pd_targets>
{CDK2,AURKA,MAPK1,FLT3,MAP3K7,MAPK10,ROCK1,MAPK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","Other protein kinase group","TK protein kinase group","TKL protein kinase group","AGC protein kinase group","CMGC protein kinase CDK family
","Other protein kinase AUR family","CMGC protein kinase MAPK family","Tyrosine protein kinase PDGFR family","TKL protein kinase MLK family","AGC protein kinase DMPK family","CMGC protein kinase CDC2 
subfamily","CMGC protein kinase ERK1","TKL protein kinase TAK1 subfamily","CMGC protein kinase JNK subfamily","AGC protein kinase ROCK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Receptor kinases","AGC: Containing PKA",PKG,"PKC families","Cyclin-dependent kinase (CD
K) family","Other protein kinases","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","DMPK family","CDK1 subfamily","Aurora kinase (Aur) family","ERK 
subfamily","Receptor tyrosine kinases (RTKs)","Mixed Lineage Kinase (MLK) family","JNK subfamily","Rho kinase","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","TAK1 subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System","Signal Transduction","Developmental Biology","RNA Polymerase II Transcription","Innate Immune System","Signaling by Receptor Tyrosine Kinases","Nerv
ous system development","Generic Transcription Pathway","Toll-like Receptor Cascades","Signaling by Insulin receptor","Axon guidance","Transcriptional Regulation by TP53","Toll Like Receptor 5 (TLR5) 
Cascade","Insulin receptor signalling cascade","Toll Like Receptor 4 (TLR4) Cascade","Semaphorin interactions","Regulation of TP53 Activity","MyD88 cascade initiated on plasma membrane","IRS-mediated 
signalling","MyD88-independent TLR4 cascade","Sema4D in semaphorin signaling","Regulation of TP53 Expression and Degradation","Regulation of TP53 Activity through Phosphorylation","MAP kinase activati
on","PI3K Cascade","TRIF(TICAM1)-mediated TLR4 signaling","Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinase
s","TRAF6-mediated induction of TAK1 complex within TLR4 complex","ERK/MAPK targets","Activation of the AP-1 family of transcription factors","ERKs are inactivated"}

> <broad_targets>
{MAPK1}

> <broad_moa>
{"MAP kinase inhibitor"}

> <synonyms>
{X11,VX-11e,VX11e,896720-20-0,896720200,VTX-11e,VTX11e,"VX 11e",NCGC00242487,Vertex-11e,Vertex11e,"TCS ERK 11e","pyrimidylpyrrole, 11e",C24H20Cl2FN5O2,CHEMBL583042,GTPL9375,SCHEMBL15859235,"VX-11e(TCS
 ERK 11e)","VX11e(TCS ERK 11e)",BDBM35657,CHEBI:95049,AOB6429,DTXSID00469774,EX-A1570,EXA1570,4157AH,s7709,ZINC3588,T3166}

> <pdid>
PD012648

> <targets>
{ERK,"Aurora A",CDK2,ERK2,FLT3,GSK-3}

> <classes>
{"Cell Cycle/Checkpoint","PI3K/Akt/mTOR signaling",Angiogenesis,MAPK,Chromatin/Epigenetic,"Stem Cells","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{11634725}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
    4.0497   -4.4250    0.0000 O   0  0
    2.5497   -4.4224    0.0000 C   0  0
    1.7974   -5.7210    0.0000 N   0  0
    2.5451   -7.0223    0.0000 C   0  0
    4.0452   -7.0225    0.0000 C   0  0
    4.7951   -8.3215    0.0000 C   0  0
    4.0450   -9.6205    0.0000 C   0  0
    2.5450   -9.6205    0.0000 C   0  0
    1.7951   -8.3214    0.0000 C   0  0
    0.2943   -8.3245    0.0000 C   0  0
   -0.4580   -7.0267    0.0000 O   0  0
   -0.4543   -9.6253    0.0000 N   0  0
   -1.9551   -9.6284    0.0000 C   0  0
   -2.6226   -8.2769    0.0000 C   0  0
   -4.0850   -7.9432    0.0000 C   0  0
   -5.2577   -8.8785    0.0000 C   0  0
   -5.2577  -10.3785    0.0000 C   0  0
   -4.0849  -11.3137    0.0000 N   0  0
   -2.6225  -10.9798    0.0000 C   0  0
   -1.6931  -12.1572    0.0000 O   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 S   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 13  1  0
 19 20  2  0
  2 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 28 29  1  0
 29 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28888

> <plate>
Kinase v5-3

> <well>
M08

> <supplier_cmpd_name>
ANA-12

> <ctcr_id>
12695

> <supplier_cmpd_id>
S7745

> <smiles>
O=C(Nc1ccccc1C(=O)NC1CCCCNC1=O)c1cc2ccccc2s1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{NTRK2}

> <broad_moa>
{"tropomyosin receptor kinase inhibitor"}

> <synonyms>
{NA1,ANA-12,ANA12,219766-25-3,219766253,"ANA 12",N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo(b)thiophene-2-carboxamide,N(2((2oxoazepan3yl)carbamoyl)phenyl)benzo(b)thiophene2carboxamide,N-(2-((2-oxo
azepan-3-yl)carbamoyl)phenyl)-1-benzothiophene-2-carboxamide,N(2((2oxoazepan3yl)carbamoyl)phenyl)1benzothiophene2carboxamide,Maybridge1_001394,Maybridge1001394,Maybridge1-001394,"Maybridge1 001394",Op
rea1_341312,Oprea1341312,Oprea1-341312,"Oprea1 341312",CHEMBL4303548,SCHEMBL17493304,HMS545,T2359}

> <pdid>
PD012841

> <targets>
{"Trk receptor",TrkB}

> <classes>
{"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{2799722}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 45  0  0  0  0            999 V2000
   13.2871   -9.4601    0.0000 C   0  0
   12.8733   -8.0183    0.0000 C   0  0
   11.4177   -7.6557    0.0000 C   0  0
   11.0039   -6.2139    0.0000 C   0  0
   12.0427   -5.1391    0.0000 C   0  0
   13.5012   -5.4972    0.0000 C   0  0
   13.9150   -6.9390    0.0000 C   0  0
   11.7445   -3.6683    0.0000 N   0  0
   12.7521   -2.5571    0.0000 N   0  0
   12.0067   -1.2554    0.0000 C   0  0
   10.5384   -1.5621    0.0000 C   0  0
   10.3953   -3.0425    0.0000 C   0  0
    9.0914   -3.7857    0.0000 N   0  0
    7.7954   -3.0289    0.0000 C   0  0
    7.8032   -1.5289    0.0000 O   0  0
    6.4915   -3.7721    0.0000 N   0  0
    5.1954   -3.0153    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -3.8794    1.4442    0.0000 C   0  0
   -4.8823    2.5608    0.0000 C   0  0
   -6.3501    2.2516    0.0000 O   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -0.3115    2.9665    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    2.5795   -7.5040    0.0000 F   0  0
    3.8864   -5.2585    0.0000 C   0  0
   12.6209    0.1112    0.0000 C   0  0
   14.1131    0.2637    0.0000 C   0  0
   11.7430    1.3275    0.0000 C   0  0
   13.2351    1.4796    0.0000 C   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  3
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  3
 12  8  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  3
 19 20  1  0
 20 21  1  0
 21 22  2  3
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  3
 26 21  1  0
 24 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 27 31  1  0
 31 32  2  3
 32 23  1  0
 19 33  1  0
 33 34  2  3
 34 35  1  0
 35 36  1  0
 35 37  2  3
 37 18  1  0
 10 38  1  0
 38 39  1  0
 38 40  1  0
 38 41  1  0
M  END
> <name>
UTKinase_V5

> <id>
28889

> <plate>
Kinase v5-3

> <well>
M10

> <supplier_cmpd_name>
Pexmetinib (ARRY-614)

> <ctcr_id>
12367

> <supplier_cmpd_id>
S7799

> <smiles>
CC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NCC1=C(OC2=CC3=C(C=C2)N(CCO)N=C3)C=CC(F)=C1)C(C)(C)C

> <pd_targets>
{FLT1,TEK,FYN,MAPK14,ABL2,HCK,LYN,FLT4,MAPK11,ABL1,FGFR1,MINK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","STE protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Tie family","Tyrosine p
rotein kinase Src family","CMGC protein kinase MAPK family","Tyrosine protein kinase Abl family","Tyrosine protein kinase FGFR family","STE protein kinase STE20 family","Tyrosine protein kinase SrcA",
"CMGC protein kinase p38 subfamily","STE protein kinase MSN subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",
"TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","STE20 family","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","p38 subfamily","MSN subfamily","Type 
IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors","Src family","Abl family","Type V RTKs: FGF (fibroblast growth factor) recepto
r family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System","Developmental Biology","Cellular responses to external stimuli","Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","Infectious di
sease","Innate Immune System","Nervous system development","Diseases of signal transduction by growth factor receptors and second messengers","Cellular responses to stress","Signaling by VEGF","MAPK1/
MAPK3 signaling","HIV Infection","Toll-like Receptor Cascades","Axon guidance","Leishmania infection","Signaling by FGFR in disease","Cellular Senescence","VEGF ligand-receptor interactions","RAF/MAP 
kinase cascade","Host Interactions of HIV factors","Toll Like Receptor 5 (TLR5) Cascade","Signaling by ROBO receptors","Leishmania parasite growth and survival","Parasite infection","Signaling by FGFR
1 in disease","Oxidative Stress Induced Senescence","VEGF binds to VEGFR leading to receptor dimerization","The role of Nef in HIV-1 replication and disease pathogenesis","MyD88 cascade initiated on p
lasma membrane","Role of ABL in ROBO-SLIT signaling","Anti-inflammatory response favouring Leishmania parasite infection","Leishmania phagocytosis","FGFR1 mutant receptor activation","Nef and signal t
ransduction","MAP kinase activation","FCGR3A-mediated IL10 synthesis","FCGR3A-mediated phagocytosis","Signaling by activated point mutants of FGFR1","MAPK targets/ Nuclear events mediated by MAP kinas
es","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
{MAPK14,TEK}

> <broad_moa>
{"MAP kinase inhibitor","TIE tyrosine kinase inhibitor"}

> <synonyms>
{Pexmetinib,945614-12-0,945614120,ARRY-614,ARRY614,"Pexmetinib (ARRY-614)","Pexmetinib (ARRY614)",UNII-3750D0U8B5,UNII3750D0U8B5,3750D0U8B5,"Pexmetinib (INN)",Pexmetinib;ARRY-614,Pexmetinib;ARRY614,Pe
xmetinib(ARRY-614),Pexmetinib(ARRY614),SCHEMBL379035,GTPL9917,CHEMBL3991932,BCP28410,EX-A1421,EXA1421,NSC778367,NSC800844,s7799,ZINC41747181,T6934}

> <pdid>
PD021544

> <targets>
{"p38 MAPK",Tie-2,Autophagy}

> <classes>
{MAPK,Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{24765037}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  1  0            999 V2000
    4.2010   -3.2956    0.0000 N   0  0
    4.9531   -1.9978    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3070    5.2494    0.0000 C   0  0
   -2.6017    2.9971    0.0000 C   0  0
    6.4430   -1.8404    0.0000 C   0  0
    7.3249   -3.0538    0.0000 O   0  0
    7.0537   -0.4695    0.0000 N   0  0
    8.5462   -0.3118    0.0000 C   0  0  2  0  0  0
    9.4261   -1.5277    0.0000 C   0  0
    8.8143   -2.8972    0.0000 O   0  0
    9.1568    1.0592    0.0000 C   0  0
   10.6483    1.2189    0.0000 C   0  0
   11.2558    2.5903    0.0000 C   0  0
   10.3718    3.8022    0.0000 C   0  0
    8.8804    3.6426    0.0000 C   0  0
    8.2729    2.2711    0.0000 C   0  0
   12.7473    2.7500    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  1  1  0
  4  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
  8 13  1  0
 13 14  1  0
 14 15  1  0
 14 16  1  0
  2 17  1  0
 17 18  2  0
 17 19  1  0
 20 19  1  1
 20 21  1  0
 21 22  1  0
 20 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 25 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28890

> <plate>
Kinase v5-3

> <well>
M12

> <supplier_cmpd_name>
Ulixertinib (BVD-523, VRT752271)

> <ctcr_id>
11915

> <supplier_cmpd_id>
S7854

> <smiles>
[nH]1c(cc(c1)c1cc(ncc1Cl)NC(C)C)C(=O)N[C@H](CO)c1cc(ccc1)Cl

> <pd_targets>
{MAPK1,MAPK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CMGC protein kinase group","CMGC protein kinase MAPK family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{}

> <broad_moa>
{"MAP kinase inhibitor"}

> <synonyms>
{Ulixertinib,869886-67-9,869886679,VRT752271,BVD-523,BVD523,UNII-16ZDH50O1U,UNII16ZDH50O1U,"Ulixertinib (INN)","Ulixertinib (BVD-523)","Ulixertinib (BVD523)","Ulixertinib (BVD-523, VRT752271)","Ulixer
tinib (BVD523, VRT752271)",16ZDH50O1U,CHEMBL3590106,"869886-67-9 (free base)","869886679 (free base)","Ulixertinib (BVD-523,VRT752271)","Ulixertinib (BVD523,VRT752271)","BVD523 HCl",T7005}

> <pdid>
PD012525

> <targets>
{ERK,ERK2}

> <classes>
{MAPK,MAPK/ERK Pathway,Stem Cell/Wnt}

> <pubchem_cids>
{11719003}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 23  0  0  0  0            999 V2000
    4.6379    5.2745    0.0000 Br  0  0
    4.3480    3.8028    0.0000 C   0  0
    5.4777    2.8159    0.0000 C   0  0
    5.1878    1.3442    0.0000 C   0  0
    3.7691    0.8603    0.0000 C   0  0
    3.1796   -0.5190    0.0000 N   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.5242    2.0130    0.0000 O   0  0
   -1.6852   -0.3847    0.0000 N   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.5000   -2.8577    0.0000 C   0  0
   -0.7500   -4.1567    0.0000 C   0  0
    0.7500   -4.1567    0.0000 C   0  0
    1.5000   -2.8577    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    2.6395    1.8472    0.0000 C   0  0
    2.9286    3.3180    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  7  1  0
 18 13  1  0
  8 19  1  0
 19  5  1  0
 19 20  2  0
 20  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28891

> <plate>
Kinase v5-3

> <well>
M14

> <supplier_cmpd_name>
Kenpaullone

> <ctcr_id>
489

> <supplier_cmpd_id>
S7917

> <smiles>
Brc1ccc2[nH]c3c(CC(=O)Nc4ccccc34)c2c1

> <pd_targets>
{MARK3,CCNB1,CDK1,ALDH1A1,KMT2A,MEN1,TP53,HTT,CYP2D6,GMNN,CDC42BPA,PLK4,LIMK1,CDC7,FLT4,CDK2,GSK3B,SRC,AURKB,CCNA1,CCNA2,CHEK1,CDK5,CDK5R1,CSNK2A1,CHEK2,MAPT,CHRM1,CYP1A2,ABL1,MARK2,FLT1,LCK,MAPK3,NFK
B1,RAB9A,SMN1,NPC1,THPO,DYRK1A,LMNA,CCNB2,CCNB3,PFMRK,PIM1,PDPK1,STK3,KDR,TSHR,HIF1A,CYP3A4,AURKA,LYN,MAPK1,THRB,NFO,RORC,BLM,CSF1R,NIN,GSK3A,ROCK2,KDM4E,PYK,FYN,HSD17B10,PMP22,PKM,CYP2C9,FLT3,ROCK1,M
TOR,CCNT1,CDK9}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Transcription factor","Unclassified protein","Other cytosolic protein","Membrane receptor",Transporter,"Other nuclear protein",Kinase,Protease,Oxidoreductase,Reader,"Cy
tochrome P450","Family A G protein-coupled receptor",Hydrolase,"Nuclear receptor",Eraser,Transferase,"Protein Kinase","Cysteine protease",Bromodomain,"Cytochrome P450 family 2","Small molecule recepto
r (family A GPCR)","Cytochrome P450 family 1","Methyl-lysine/arginine binding protein","Peptide receptor (family A GPCR)","Cytochrome P450 family 3","Nuclear hormone receptor subfamily 1","Lysine deme
thylase","CAMK protein kinase group","CMGC protein kinase group","Cysteine protease CA clan","Cytochrome P450 family 2D","AGC protein kinase group","Other protein kinase group","TKL protein kinase gro
up","TK protein kinase group","Monoamine receptor","Cytochrome P450 family 1A","Tudor domain","STE protein kinase group","Glycohormone receptor","Cytochrome P450 family 3A","Nuclear hormone receptor s
ubfamily 1 group A","Nuclear hormone receptor subfamily 1 group F","Jumonji domain-containing","Cytochrome P450 family 2C","Atypical protein kinase group","CAMK protein kinase CAMK1 family","CMGC prot
ein kinase CDK family","Cysteine protease C1A family","Cytochrome P450 2D6","AGC protein kinase DMPK family","Other protein kinase PLK family","TKL protein kinase LISK family","Other protein kinase CD
C7 family","Tyrosine protein kinase VEGFR family","CMGC protein kinase GSK family","Tyrosine protein kinase Src family","Other protein kinase AUR family","Other protein kinase CK2 family","CAMK protei
n kinase RAD53 family","Acetylcholine receptor","Cytochrome P450 1A1","Tyrosine protein kinase Abl family","CMGC protein kinase MAPK family","CMGC protein kinase DYRK family","CAMK protein kinase PIM 
family","AGC protein kinase PDK1 subfamily","STE protein kinase STE20 family","Cytochrome P450 3A4","Nuclear hormone receptor subfamily 1 group A member 2","Nuclear hormone receptor subfamily 1 group 
F member 3","Tyrosine protein kinase PDGFR family","Cytochrome P450 2C9","Atypical protein kinase PIKK family","CAMK protein kinase MARK subfamily","CMGC protein kinase CDC2 subfamily","AGC protein ki
nase GEK subfamily","TKL protein kinase LIMK subfamily","CAMK protein kinase CHK1 subfamily","CMGC protein kinase ERK1","CMGC protein kinase CDK5 subfamily","CMGC protein kinase Dyrk1 subfamily","STE 
protein kinase MST subfamily","AGC protein kinase ROCK subfamily","Tyrosine protein kinase SrcA","Atypical protein kinase FRAP subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,Transporters,"Kinases (EC 2.7.x.x)","Cytochrome P450","Catalytic receptors","G protein-coupled receptors","SLC superfamily of solute carriers","Nuclear hormone receptors","Chromatin
 modifying enzymes","2.7.1.40 Pyruvate kinases","CAMK: Calcium/calmodulin-dependent protein kinases","CYP2 family: drug metabolising subset","AGC: Containing PKA",PKG,"PKC families","Receptor kinases"
,"CMGC: Containing CDK",MAPK,GSK3,"CLK families","Acetylcholine receptors (muscarinic)","CYP1 family","SLC65 NPC-type cholesterol transporters","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile
 20 kinases","Glycoprotein hormone receptors","CYP3 family","1A. Thyroid hormone receptors","1F. Retinoic acid-related orphans","1.14.11.- Histone demethylases",Atypical,"CAMK-like (CAMKL) family","DM
PK family","Other protein kinases","TKL: Tyrosine kinase-like","TK: Tyrosine kinase","Cyclin-dependent kinase (CDK) family","Glycogen synthase kinase (GSK) family","Mitogen-activated protein kinases (
MAP kinases)","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","PIM family","PDK1 family","STE20 family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","
MARK subfamily","GEK subfamily","Polo-like kinase (PLK) family","LIM domain kinase (LISK) family","CDC7 family","Receptor tyrosine kinases (RTKs)","CDK1 subfamily","GSK subfamily","Non-receptor tyrosi
ne kinases (nRTKs)","Aurora kinase (Aur) family","CHK1 subfamily","Casein kinase 2 (CK2) family","ERK subfamily","CDK5 subfamily","Dyrk1 subfamily","MST subfamily","Rho kinase","FRAP subfamily","LIMK 
subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Src family","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{Disease,Metabolism,"Cell Cycle","Gene expression (Transcription)","Developmental Biology","Signal Transduction","DNA Repair","Neuronal System","Immune System","Metabolism of RNA","Transport of small 
molecules",Hemostasis,"Cellular responses to external stimuli","Metabolism of proteins","Diseases of signal transduction by growth factor receptors and second messengers","Biological oxidations","Cell
 Cycle Checkpoints","RNA Polymerase II Transcription",Mitotic,"Nervous system development","Signaling by Receptor Tyrosine Kinases","Infectious disease","DNA Double-Strand Break Repair","Transmission 
across Chemical Synapses","Signaling by GPCR","Innate Immune System","Cytokine Signaling in Immune system","Signaling by Rho GTPases","Metabolism of non-coding RNA","Plasma lipoprotein assembly",remod
eling,"and clearance","Platelet activation","signaling and aggregation","Signaling by Hippo","Cellular responses to stress","Metabolism of lipids","Post-translational protein modification","Metabolism
 of amino acids and derivatives","Metabolism of carbohydrates","Oncogenic MAPK signaling","Phase I - Functionalization of compounds","G1/S DNA Damage Checkpoints","Generic Transcription Pathway","Mito
tic G1 phase and G1/S transition","Mitotic G2-G2/M phases","Axon guidance","Signaling by VEGF","SARS-CoV Infections","Signaling by NTRKs","M Phase","Homology Directed Repair","Neurotransmitter recepto
rs and postsynaptic signal transmission","GPCR ligand binding","Leishmania infection","HIV Infection","Toll-like Receptor Cascades","Signaling by Interleukins","Rho GTPase cycle","snRNP Assembly","Pla
sma lipoprotein clearance","Platelet Aggregation (Plug Formation)","FLT3 signaling in disease","Cellular response to hypoxia","Biosynthesis of specialized proresolving mediators (SPMs)",SUMOylation,"B
ranched-chain amino acid catabolism","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Glucose metabolism","Signaling by Insulin receptor","Regulation of mitotic cell cycle","Signaling
 by RAS mutants","Ethanol oxidation","p53-Dependent G1/S DNA damage checkpoint","Transcriptional Regulation by MECP2","Cytochrome P450 - arranged by substrate type","G1/S Transition","G2/M Transition"
,"Semaphorin interactions","VEGF ligand-receptor interactions","Transcriptional Regulation by TP53","SARS-CoV-1 Infection","Signaling by NTRK1 (TRKA)","Mitotic Metaphase and Anaphase","HDR through Hom
ologous Recombination (HRR) or Single Strand Annealing (SSA)","Activation of NMDA receptors and postsynaptic events","Class A/1 (Rhodopsin-like receptors)","Parasite infection","Host Interactions of H
IV factors","Toll Like Receptor 5 (TLR5) Cascade","Interleukin-1 family signaling","RHOBTB GTPase Cycle","LDL clearance","G0 and Early G1","Signaling by FLT3 ITD and TKD mutants","VEGFA-VEGFR2 Pathway
","Leishmania parasite growth and survival","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Biosynthesis of DHA-derived SPMs","SUMO E3 ligases SUMOylate target proteins","T
ranscriptional regulation by RUNX3","Transcriptional Regulation by VENTX",Glycolysis,"Insulin receptor signalling cascade","APC/C-mediated degradation of cell cycle proteins","Signaling downstream of 
RAS mutants","p53-Dependent G1 DNA Damage Response","Regulation of MECP2 expression and activity",Xenobiotics,"Activation of the pre-replicative complex","Centrosome maturation","Sema4D in semaphorin 
signaling","VEGF binds to VEGFR leading to receptor dimerization","Regulation of TP53 Activity","SARS-CoV-1 Genome Replication and Transcription","Signalling to ERKs","Mitotic Anaphase","HDR through H
omologous Recombination (HRR)","Post NMDA receptor activation events","Amine ligand-binding receptors","Leishmania phagocytosis","The role of Nef in HIV-1 replication and disease pathogenesis","MyD88 
cascade initiated on plasma membrane","Interleukin-1 signaling","RHOBTB3 ATPase cycle","STAT5 activation downstream of FLT3 ITD mutants","VEGFR2 mediated cell proliferation","Anti-inflammatory respons
e favouring Leishmania parasite infection","Biosynthesis of maresins","SUMOylation of intracellular receptors","RUNX3 Regulates Immune Response and Cell Migration","IRS-mediated signalling","Activatio
n of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Stabilization of p53","CYP2E1 reactions","Loss of proteins required for interphase microtubule organization from the centrosome","
Sema4D induced cell migration and growth-cone collapse","Regulation of TP53 Expression and Degradation","Replication of the SARS-CoV-1 genome","Signalling to RAS","Separation of Sister Chromatids","Ho
mologous DNA Pairing and Strand Exchange","Regulation of TP53 Activity through Phosphorylation","Activation of AMPK downstream of NMDARs","Muscarinic acetylcholine receptors","Aromatic amines can be N
-hydroxylated or N-dealkylated by CYP1A2","FCGR3A-mediated phagocytosis","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","MAP kinase activation","MAP3K
8 (TPL2)-dependent MAPK1/3 activation","Nuclear Envelope (NE) Reassembly","ADORA2B mediated anti-inflammatory cytokines production","Biosynthesis of maresin-like SPMs","FCGR3A-mediated IL10 synthesis"
,"Nef and signal transduction","PI3K Cascade","APC/C:Cdc20 mediated degradation of mitotic proteins","Autodegradation of the E3 ubiquitin ligase COP1","Loss of Nlp from mitotic centrosomes","Regulatio
n of TP53 Degradation","p38MAPK events","Presynaptic phase of homologous DNA pairing and strand exchange","Nef Mediated CD4 Down-regulation","MAPK targets/ Nuclear events mediated by MAP kinases","Ini
tiation of Nuclear Envelope (NE) Reformation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","ERK/MAPK targets","Cdc20:Phospho-APC/C mediated
 degradation of Cyclin A","ERKs are inactivated"}

> <broad_targets>
{CCNB1,CDK1,CDK5,GSK3B}

> <broad_moa>
{"CDK inhibitor","glycogen synthase kinase inhibitor"}

> <synonyms>
{kenpaullone,142273-20-9,142273209,9-Bromopaullone,9Bromopaullone,"NSC 664704","9-Bromo-7,12-dihydroindolo(3,2-d)(1)benzazepin-6(5H)-one","9Bromo7,12dihydroindolo(3,2d)(1)benzazepin6(5H)one",NSC-66470
4,NSC664704,9-Bromopaullone;NSC-664704,9Bromopaullone;NSC664704,"9-bromo-7,12-dihydrobenzo(2,3)azepino(4,5-b)indol-6(5H)-one","9bromo7,12dihydrobenzo(2,3)azepino(4,5b)indol6(5H)one",Indolo(3,2-d)(1)be
nz,2d)(1)benz,T2247,"EMD 422000",EI-310,KenPaullone,422000,Kenpaullone}

> <pdid>
PD002702

> <targets>
{CDK,GSK-3beta}

> <classes>
{}

> <pubchem_cids>
{3820}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 23  0  0  0  0            999 V2000
   18.1999   -1.5000    0.0000 C   0  0
   18.1999    0.0000    0.0000 C   0  0
   16.9009   -0.7502    0.0000 C   0  0
   16.8999    0.7500    0.0000 C   0  0
   15.5999    0.0000    0.0000 C   0  0
   14.2999    0.7500    0.0000 C   0  0
   12.9999    0.0000    0.0000 C   0  0
   11.6999    0.7500    0.0000 C   0  0
   10.3999    0.0000    0.0000 C   0  0
   10.3999   -1.5000    0.0000 O   0  0
    9.0999    0.7500    0.0000 C   0  0
    7.7999    0.0000    0.0000 C   0  0
    6.5000    0.7500    0.0000 C   0  0
    5.2000    0.0000    0.0000 C   0  0
    3.9000    0.7500    0.0000 C   0  0
    2.6000    0.0000    0.0000 C   0  0
    3.8989   -0.7502    0.0000 C   0  0
    2.6000   -1.5000    0.0000 C   0  0
    1.3000    0.7500    0.0000 C   0  0
    0.0007    0.0004    0.0000 O   0  0
    1.3000    2.2500    0.0000 O   0  0
   19.4998    0.7500    0.0000 C   0  0
   20.7991    0.0004    0.0000 O   0  0
   19.4998    2.2500    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 16 18  1  0
 16 19  1  0
 19 20  2  0
 19 21  1  0
  2 22  1  0
 22 23  2  0
 22 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28892

> <plate>
Kinase v5-3

> <well>
M16

> <supplier_cmpd_name>
ETC-1002

> <ctcr_id>
11772

> <supplier_cmpd_id>
S7953

> <smiles>
CC(C)(CCCCCC(O)CCCCCC(C)(C)C(=O)O)C(=O)O

> <pd_targets>
{ACLY}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{}

> <pathway_reactome>
{Metabolism,"Metabolism of lipids","Fatty acid metabolism","Fatty acyl-CoA biosynthesis"}

> <broad_targets>
{ACLY}

> <broad_moa>
{"AMPK inhibitor"}

> <synonyms>
{TC100,"TC 100","bempedoic acid",ETC-1002,ETC1002,"ETC 1002",738606-46-7,738606467,"738606 46 7","8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid","8Hydroxy2,2,14,14tetramethylpentadecanedioic ac
id","8 Hydroxy 2,2,14,14 tetramethylpentadecanedioic acid",Nexletol,ESP-55016,ESP55016,"ESP 55016",Nilemdo,UNII-1EJ6Z6Q368,UNII1EJ6Z6Q368,"UNII 1EJ6Z6Q368",1EJ6Z6Q368,ETC-1002;ESP-55016,ETC1002;ESP550
16,"ETC 1002;ESP 55016",Bempedoate,"Bempedoic acid (USAN:INN)",bempedoic-,bempedoic,T3625}

> <pdid>
PD050470

> <targets>
{AMPK,LDL,ACL,"ATP Citrate Lyase"}

> <classes>
{Neuroscience,Epigenetics,Metabolic Enzyme/Protease,PI3K/Akt/mTOR}

> <pubchem_cids>
{10472693}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  1  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.0114   -1.7530    0.0000 S   0  0
   -4.4013   -3.1233    0.0000 C   0  0
   -2.9095   -2.9665    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -2.5981    1.5000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    0.0092   -7.5017    0.0000 C   0  0  1  0  0  0
    1.3107   -8.2475    0.0000 C   0  0
   -1.2879   -8.2567    0.0000 C   0  0
   -1.2835   -9.7576    0.0000 N   0  0
   -2.5798  -10.5122    0.0000 C   0  0
    0.0180  -10.5033    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
    5.0987   -3.7559    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12  8  1  0
  9 13  1  0
 13 14  2  0
 13 15  1  0
 15  6  1  0
  7 16  2  0
 16  2  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  1
 21 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 20 27  1  0
 27 28  2  0
 28 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28894

> <plate>
Kinase v5-3

> <well>
P08

> <supplier_cmpd_name>
OTS964

> <ctcr_id>
12748

> <supplier_cmpd_id>
S7648

> <smiles>
Oc1cc(C)c2c(c3c(scc3)c(=O)[nH]2)c1c1ccc([C@@H](C)CN(C)C)cc1.Cl

> <pd_targets>
{PBK,NEK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase TOPK family","Other protein kinase NEK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","TOPK family","NIMA (never in mitosis gene a)- related kinase (NEK) family"}

> <pathway_reactome>
{}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{OTS-964,OTS964,1338545-07-5,1338545075,"OTS964 HCl","1338545-07-5 (HCl)","1338545075 (HCl)","OTS964 (hydrochloride)",SCHEMBL15092325,BCP28759,EX-A1467,EXA1467,CS-5121,CS5121,AC-29895,AC29895,AS-55866
,AS55866,HY-12467,HY12467,T4135}

> <pdid>
PD046247

> <targets>
{TOPK}

> <classes>
{MAPK}

> <pubchem_cids>
{89675898}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -6.4994    0.7432    0.0000 C   0  0
   -7.7985    1.4932    0.0000 C   0  0
   -7.7985    2.9932    0.0000 C   0  0
   -6.4995    3.7432    0.0000 C   0  0
   -5.2004    2.9933    0.0000 C   0  0
   -6.4995    5.2440    0.0000 N   0  0
   -7.7117    6.1057    0.0000 C   0  0
   -7.2460    7.5316    0.0000 C   0  0
   -5.7460    7.5292    0.0000 N   0  0
   -5.2847    6.1019    0.0000 C   0  0
   -8.1258    8.7465    0.0000 C   0  0
   -9.0982    0.7427    0.0000 C   0  0
   -9.0991   -0.7573    0.0000 F   0  0
  -10.3970    1.4931    0.0000 F   0  0
  -10.3976   -0.0067    0.0000 F   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8915    3.7585    0.0000 N   0  0
    3.8863    5.2585    0.0000 C   0  0
    2.5847    6.0040    0.0000 C   0  0
    1.2883    5.2495    0.0000 C   0  0
    1.2934    3.7495    0.0000 N   0  0
   -0.0140    5.9954    0.0000 C   0  0
   -0.0217    7.4954    0.0000 N   0  0
   -1.3245    8.2388    0.0000 C   0  0
   -2.6197    7.4823    0.0000 C   0  0
   -2.6122    5.9823    0.0000 N   0  0
   -1.3094    5.2389    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 15 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 17  1  0
 19 22  1  0
 13 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
  3 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 32 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 39 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28895

> <plate>
Kinase v5-3

> <well>
O20

> <supplier_cmpd_name>
Radotinib

> <ctcr_id>
11153

> <supplier_cmpd_id>
Se S8134

> <smiles>
Cc1c(cc(cc1)C(=O)Nc1cc(cc(c1)n1cc(nc1)C)C(F)(F)F)Nc1nccc(n1)c1nccnc1

> <pd_targets>
{ABL1,PDGFRB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Abl family","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Abl family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 
receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Infectious disease","Intracellular signaling by second messengers","Leishmania infection","PIP3 activates AKT signaling","Parasite infection","Negative regulation of th
e PI3K/AKT network","Leishmania phagocytosis",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","FCGR3A-mediated phagocytosis"}

> <broad_targets>
{}

> <broad_moa>
{"Bcr-Abl kinase inhibitor"}

> <synonyms>
{Radotinib,926037-48-1,926037481,supect,IY-5511,IY5511,Radotinib(IY-5511),Radotinib(IY5511),UNII-I284LJY110,UNIII284LJY110,I284LJY110,"926037-48-1 (free base)","926037481 (free base)",IY5511HCl,"Radot
inib (INN)","Radotinib (IY-5511)","Radotinib (IY5511)","Radotinib; IY-5511;","Radotinib; IY5511;",GTPL7814,SCHEMBL3359952,CHEMBL4297524,DTXSID90239069,AOB8,T2328}

> <pdid>
PD046857

> <targets>
{Bcr-Abl,Bcr-Abl1}

> <classes>
{Angiogenesis,"Cytoskeletal Signaling"}

> <pubchem_cids>
{16063245}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 F   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5988   -1.5004    0.0000 C   0  0
   -3.8978   -2.2504    0.0000 N   0  0
    2.5987    1.5004    0.0000 C   0  0
    3.9511    0.8815    0.0000 C   0  0
    4.9530    1.9978    0.0000 S   0  0
    4.2010    3.2957    0.0000 C   0  0
    4.8092    4.6676    0.0000 N   0  0
    6.2798    4.9368    0.0000 C   0  0
    6.7828    6.3500    0.0000 C   0  0
    5.8105    7.4922    0.0000 O   0  0
    4.3352    7.2212    0.0000 C   0  0
    3.8322    5.8081    0.0000 C   0  0
    2.7342    2.9815    0.0000 C   0  0
    1.6117    3.9736    0.0000 C   0  0
    0.4877    4.9669    0.0000 N   0  0
    4.2568   -0.5878    0.0000 C   0  0
    3.3397   -1.7522    0.0000 N   0  0
    4.1890   -2.9886    0.0000 C   0  0
    5.6273   -2.5629    0.0000 N   0  0
    5.6670   -1.0635    0.0000 N   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  3
  7  2  1  0
  6  8  1  0
  8  9  3  0
  3 10  1  0
 10 11  2  3
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
 13 20  2  3
 20 10  1  0
 20 21  1  0
 21 22  3  0
 11 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  3
 26 27  1  0
 27 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28897

> <plate>
Kinase v5-3

> <well>
O04

> <supplier_cmpd_name>
PF-4989216

> <ctcr_id>
12216

> <supplier_cmpd_id>
S7675

> <smiles>
FC1=C(C=CC(=C1)C#N)C1=C(SC(N2CCOCC2)=C1C#N)C1=NC=NN1

> <pd_targets>
{PIK3CA,MTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfami
ly"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Signaling by FGFR in disease","Generic 
Transcription Pathway","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","FGFR1 mutant receptor activation","Regulation of TP53 Activity","Signaling by cytosolic FGFR1 fusion mutant
s","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{F498921,PF-4989216,PF4989216,1276553-09-3,1276553093,CHEMBL2017654,SCHEMBL20768081,BCP15976,EX-A2310,EXA2310,BDBM50380321,NSC777877,s7675,ZINC84619044,CCG-268405,CCG268405,CS-5205,CS5205,NSC-777877,N
CGC00475739-02,NCGC0047573902,HY-13864,HY13864,B5948,A12889,T6938}

> <pdid>
PD012671

> <targets>
{PI3K,p110¦Ä£»p110¦Á£»p110¦Ã£»Vps34£»p110¦Â,Apoptosis}

> <classes>
{PI3K/Akt/mTOR,Apoptosis}

> <pubchem_cids>
{51033720}

$$$$
UTKinase_V5
  SciTegic11012413002D

 47 52  0  0  0  0            999 V2000
    2.5569  -12.0048    0.0000 C   0  0
    2.5644  -10.5048    0.0000 N   0  0
    3.8672   -9.7614    0.0000 C   0  0
    3.8748   -8.2614    0.0000 C   0  0
    2.5795   -7.5047    0.0000 N   0  0
    1.2767   -8.2483    0.0000 C   0  0
    1.2692   -9.7483    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 N   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.6011   -3.0008    0.0000 C   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9072   -5.2494    0.0000 C   0  0
   -5.2089   -5.9949    0.0000 C   0  0
   -6.5053   -5.2405    0.0000 C   0  0
   -6.5001   -3.7405    0.0000 C   0  0
   -5.1985   -2.9950    0.0000 C   0  0
   -7.8092   -5.9837    0.0000 N   0  0
   -9.1052   -5.2270    0.0000 C   0  0
   -9.0975   -3.7270    0.0000 O   0  0
  -10.4091   -5.9702    0.0000 C   0  0
  -11.7045   -5.2139    0.0000 C   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -6.4995    3.7483    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -6.4948    0.7483    0.0000 C   0  0
   -9.0920    0.7411    0.0000 O   0  0
   -9.0875   -0.7589    0.0000 C   0  0
   -6.5050    5.2492    0.0000 O   0  0
   -7.8063    5.9952    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 18  1  0
 24 25  2  0
 25 15  1  0
 23 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 30 33  1  0
 33 34  1  0
 34 35  2  0
 34 36  1  0
 36 37  2  0
 20 38  1  0
 38 39  2  0
 39 40  1  0
 40 41  2  0
 41 42  1  0
 42 43  2  0
 43 38  1  0
 42 44  1  0
 44 45  1  0
 40 46  1  0
 46 47  1  0
M  END
> <name>
UTKinase_V5

> <id>
28898

> <plate>
Kinase v5-3

> <well>
O06

> <supplier_cmpd_name>
FIIN-2

> <ctcr_id>
12557

> <supplier_cmpd_id>
S7714

> <smiles>
CN1CCN(CC1)c1ccc(cc1)Nc1ncc2CN(C(=O)N(c2n1)Cc1ccc(cc1)NC(=O)C=C)c1cc(cc(c1)OC)OC

> <pd_targets>
{FGFR3,FGFR4,FGFR2,FGFR1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase FGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type V RTKs: FGF (fibroblast growth factor) receptor family"}

> <pathway_reactome>
{Disease,"Signal Transduction","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","Signaling by FGFR in disease","Signaling by 
FGFR","Signaling by FGFR3 in disease","Signaling by FGFR4","Signaling by FGFR2 in disease","Signaling by FGFR1 in disease","Signaling by FGFR3 point mutants in cancer","Downstream signaling of activat
ed FGFR4","FGFR2 mutant receptor activation","FGFR1 mutant receptor activation","FGFR3 mutant receptor activation","FRS-mediated FGFR4 signaling","Activated point mutants of FGFR2","Signaling by activ
ated point mutants of FGFR1","Signaling by activated point mutants of FGFR3"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{IIN,FIIN-2,FIIN2,1633044-56-0,1633044560,CHEMBL4065323,SCHEMBL17857061,BCP14779,EX-A1742,EXA1742,BDBM50232829,s7714,AKOS025287401,ZINC250363839,CCG-270298,CCG270298,CS-5343,CS5343,NCGC00484066-01,NCG
C0048406601,AC-32963,AC32963,HY-18602,HY18602,DS-015817,DS015817,A12357,T6836}

> <pdid>
PD021568

> <targets>
{FGFR,FGFR1,FGFR2,FGFR3,FGFR4}

> <classes>
{Angiogenesis,Tyrosine Kinase/Adaptors,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{91825767}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -6.5002    3.7446    0.0000 C   0  0
   -7.7969    2.9905    0.0000 C   0  0
   -9.0983    3.7364    0.0000 C   0  0
   -9.1031    5.2364    0.0000 N   0  0
   -7.8065    5.9905    0.0000 C   0  0
   -6.5050    5.2446    0.0000 C   0  0
   -5.2078    5.9992    0.0000 C   0  0
   -3.9051    5.2554    0.0000 C   0  0
   -2.6096    6.0116    0.0000 C   0  0
   -1.3070    5.2679    0.0000 F   0  0
   -2.6168    7.5116    0.0000 C   0  0
   -1.3213    8.2678    0.0000 O   0  0
   -3.9194    8.2554    0.0000 C   0  0
   -3.9265    9.7554    0.0000 F   0  0
   -5.2148    7.4992    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 24 25  1  0
 24 26  1  0
 26 27  1  0
 26 28  2  0
 28 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28901

> <plate>
Kinase v5-3

> <well>
O12

> <supplier_cmpd_name>
LJH685

> <ctcr_id>
12801

> <supplier_cmpd_id>
S7870

> <smiles>
CN1CCN(CC1)c1ccc(cc1)c1ccncc1c1cc(F)c(O)c(F)c1

> <pd_targets>
{RPS6KA3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","AGC protein kinase group","AGC protein kinase RSK family","AGC protein kinase RSK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","RSK family","RSK subfamily"}

> <pathway_reactome>
{"Immune System","Innate Immune System","Toll-like Receptor Cascades","Toll Like Receptor 5 (TLR5) Cascade","MyD88 cascade initiated on plasma membrane","MAP kinase activation","MAPK targets/ Nuclear 
events mediated by MAP kinases","CREB phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{LJH685,1627710-50-2,1627710502,LJH-685,"2,6-Difluoro-4-(4-(4-(4-Methylpiperazin-1-Yl)phenyl)pyridin-3-Yl)phenol","2,6Difluoro4(4(4(4Methylpiperazin1Yl)phenyl)pyridin3Yl)phenol",UNII-27CZQ807C1,UNII27
CZQ807C1,CHEMBL3604793,"LJH 685",27CZQ807C1,"2,6-Difluoro-4-(4-(4-(4-methyl-1-piperazinyl)phenyl)-3-pyridinyl)-phenol","2,6Difluoro4(4(4(4methyl1piperazinyl)phenyl)3pyridinyl)phenol",2,6-difluoro-4-(4
-(,6difluoro4(4(,T6877}

> <pdid>
PD071553

> <targets>
{"S6 Kinase",RSK1,RSK2,RSK3}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{73010393}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    5.1894   -6.0109    0.0000 N   0  0
    5.1895   -7.5109    0.0000 C   0  0
    6.4885   -8.2610    0.0000 C   0  0
    7.7875   -7.5110    0.0000 C   0  0
    7.7876   -6.0110    0.0000 C   0  0
    6.4885   -5.2610    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
    0.6890    4.0818    0.0000 C   0  0
    2.1578    3.7735    0.0000 C   0  0
    2.7474    2.4081    0.0000 C   0  0
    4.2391    2.5658    0.0000 N   0  0
    4.5496    4.0325    0.0000 C   0  0
    3.2501    4.7817    0.0000 C   0  0
    3.2491    6.2817    0.0000 C   0  0
    4.5477    7.0325    0.0000 C   0  0
    5.8472    6.2833    0.0000 C   0  0
    5.8482    4.7833    0.0000 C   0  0
    4.5498    8.5333    0.0000 O   0  0
    5.8495    9.2823    0.0000 C   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.5533    4.4223    0.0000 O   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  1  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 17  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 23 26  1  0
 26 27  1  0
 15 28  1  0
 28 29  2  0
 28 30  1  0
 30 31  1  0
 31 14  2  0
 31 32  1  0
 32 33  2  0
 33 12  1  0
M  END
> <name>
UTKinase_V5

> <id>
28902

> <plate>
Kinase v5-3

> <well>
O14

> <supplier_cmpd_name>
DEL-22379

> <ctcr_id>
11974

> <supplier_cmpd_id>
S7921

> <smiles>
N1(CCCCC1)CCC(=O)Nc1cc2/C(=C\c3c[nH]c4c3cc(cc4)OC)/C(=O)Nc2cc1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{EL2237,DEL-22379,DEL22379,181223-80-3,181223803,SCHEMBL6266403,SCHEMBL8428761,ZINC838770,AC-29889,AC29889,AS-56081,AS56081,T6818}

> <pdid>
PD021514

> <targets>
{ERK}

> <classes>
{MAPK}

> <pubchem_cids>
{67583183}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 46  0  0  0  0            999 V2000
    7.8985   12.9374    0.0000 C   0  0
    7.4375   11.5100    0.0000 N   0  0
    8.4432   10.3970    0.0000 C   0  0
    7.9821    8.9696    0.0000 C   0  0
    6.5154    8.6551    0.0000 N   0  0
    5.5098    9.7682    0.0000 C   0  0
    5.9708   11.1956    0.0000 C   0  0
    6.0519    7.2277    0.0000 C   0  0
    7.0558    6.1132    0.0000 C   0  0
    6.5925    4.6865    0.0000 C   0  0
    5.1253    4.3743    0.0000 C   0  0
    4.1214    5.4890    0.0000 C   0  0
    4.5847    6.9156    0.0000 C   0  0
    4.6588    2.9478    0.0000 C   0  0
    5.6608    1.8315    0.0000 O   0  0
    3.1904    2.6376    0.0000 N   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 N   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -5.1851   -3.0091    0.0000 F   0  0
   -7.7988    1.4819    0.0000 F   0  0
    7.5992    3.5734    0.0000 N   0  0
    9.0668    3.8879    0.0000 C   0  0
   10.0746    2.7769    0.0000 C   0  0
   11.5407    3.0941    0.0000 C   0  0
   11.9990    4.5223    0.0000 O   0  0
   10.9912    5.6334    0.0000 C   0  0
    9.5252    5.3162    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 21 17  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 23 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  2  0
 32 27  1  0
 31 33  1  0
 29 34  1  0
 10 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 39  1  0
 39 40  1  0
 40 41  1  0
 41 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28904

> <plate>
Kinase v5-3

> <well>
O18

> <supplier_cmpd_name>
Entrectinib (RXDX-101)

> <ctcr_id>
11490

> <supplier_cmpd_id>
S7998

> <smiles>
CN1CCN(CC1)c1cc(c(cc1)C(=O)Nc1n[nH]c2c1cc(cc2)Cc1cc(cc(c1)F)F)NC1CCOCC1

> <pd_targets>
{SRC,KDR,AURKA,TNK2,MAP4K2,IGF1R,NTRK2,FGFR3,MST1R,PTK6,RET,ROS1,GRK5,PTK2,SLK,MAP4K5,JAK1,ALK,NTRK3,NTRK1,JAK3,CSF1R,AXL,STK3,FGFR1,PRKCG,HIPK2,BTK,FER,CLK4,FYN,TAOK1,MET,TBK1,LTK,KIT,LYN,BLK,PKN2,CD
K7,FLT1,JAK2,PRKAA1,RPS6KA3,LCK,AURKB,FLT3,DAPK3,CAMK1D,SYK,PLK4,INSR,ABL1,FLT4,MAP4K4,PRKCQ,FRK,CLK2,LRRK2,EML4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Other protein kinase group","STE protein kinase group","AGC protein kinase group","TKL protein kinase group","CMGC protein kinase group","CAM
K protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","Other protein kinase AUR family","Tyrosine protein kinase Ack family","STE protein kinase STE20 fam
ily","Tyrosine protein kinase InsR family","Tyrosine protein kinase Trk family","Tyrosine protein kinase FGFR family","Tyrosine protein kinase Met family","Tyrosine protein kinase Ret family","Tyrosin
e protein kinase Sev family","AGC protein kinase GRK family","Tyrosine protein kinase Fak family","Tyrosine protein kinase JakA family","TKL protein kinase STKR family","Tyrosine protein kinase PDGFR 
family","Tyrosine protein kinase Axl family","AGC protein kinase PKC family","CMGC protein kinase DYRK family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Fer family","CMGC protein k
inase CLK family","Other protein kinase IKK family","Tyrosine protein kinase Alk family","AGC protein kinase PKN family","CMGC protein kinase CDK family","CAMK protein kinase CAMK1 family","AGC protei
n kinase RSK family","CAMK protein kinase DAPK family","Tyrosine protein kinase Syk family","Other protein kinase PLK family","Tyrosine protein kinase Abl family","TKL protein kinase LRRK family","STE
 protein kinase KHS subfamily","AGC protein kinase GRK subfamily","STE protein kinase SLK subfamily","TKL protein kinase STKR Type 1 subfamily","STE protein kinase MST subfamily","AGC protein kinase P
KC alpha subfamily","CMGC protein kinase HIPK subfamily","Tyrosine protein kinase SrcA","STE protein kinase TAO subfamily","CMGC protein kinase CDK7 subfamily","CAMK protein kinase AMPK subfamily","AG
C protein kinase RSK subfamily","STE protein kinase MSN subfamily","AGC protein kinase PKC delta subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CMGC: 
Containing CDK",MAPK,GSK3,"CLK families","CAMK: Calcium/calmodulin-dependent protein kinases","TK: Tyrosine kinase","Other protein kinases","STE20 family","G protein-coupled receptor kinases (GRKs)","
Protein kinase C (PKC) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CLK family","Protein kinase N (PKN) family","Cyclin-dependent kinase (CDK) family","CAMK-
like (CAMKL) family","RSK family","Death-associated kinase (DAPK) family","CAMK1 family","TKL: Tyrosine kinase-like","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Aurora 
kinase (Aur) family","KHS subfamily","GRK4 subfamily","SLK subfamily","MST subfamily","Alpha subfamily","HIPK subfamily","TAO subfamily","IKK family","CDK7 subfamily","AMPK subfamily","RSK subfamily",
"Polo-like kinase (PLK) family","MSN subfamily","Delta subfamily","Leucine-rich repeat kinase (LRRK) family","Src family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Ack
 family","Type II RTKs: Insulin receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type X RTKs: HGF (hepatocyte growth fa
ctor) receptor family","Type XIV RTKs: RET","Type XVII RTKs: ROS receptors","Fak family","Janus kinase (JakA) family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type III RTKs: P
DGFR",CSFR,Kit,"FLT3 receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Tec family","Fer family","Syk family","Abl family"}

> <pathway_reactome>
{"Signal Transduction","Gene expression (Transcription)",Disease,"Cell Cycle","Developmental Biology","Immune System","Neuronal System","Programmed Cell Death","Cellular responses to external stimuli"
,"Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Diseases of signal transduction by growth factor receptors and second messengers",Mitotic,"Nervous system development","Sig
naling by GPCR","Infectious disease","Cytokine Signaling in Immune system","Signaling by Hippo","Transmission across Chemical Synapses","Innate Immune System","Signaling by Rho GTPases",Apoptosis,"Int
racellular signaling by second messengers","Cellular responses to stress","Signaling by Non-Receptor Tyrosine Kinases","Signaling by NTRKs","Signaling by VEGF","Generic Transcription Pathway","Signali
ng by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","Signaling by FGFR in disease","Signaling by MST1","Mitotic G1 phase and G1/S transition","Axon guidance","GPCR downstream signalling","Leis
hmania infection","Interferon Signaling","Signaling by Interleukins","Neurotransmitter receptors and postsynaptic signal transmission","Signaling by SCF-KIT","HIV Infection","M Phase","Toll-like Recep
tor Cascades","Signaling by KIT in disease","RHO GTPase Effectors","Signaling by Insulin receptor","Caspase activation via extrinsic apoptotic signalling pathway","Mitotic G2-G2/M phases","PIP3 activa
tes AKT signaling","Cellular Senescence","Signaling by PTK6","Signaling by NTRK1 (TRKA)","VEGFA-VEGFR2 Pathway","Transcriptional Regulation by TP53","IGF1R signaling cascade","Signaling by FGFR3 in di
sease","G1 Phase","RET signaling","G alpha (q) signalling events","Parasite infection","Antiviral mechanism by IFN-stimulated genes","Signaling by NTRK3 (TRKC)","Interleukin-2 family signaling","Trans
criptional Regulation by VENTX","Signaling by FGFR1 in disease","Glutamate binding","activation of AMPA receptors and synaptic plasticity","Host Interactions of HIV factors","Mitotic Metaphase and Ana
phase","Semaphorin interactions","Toll Like Receptor 4 (TLR4) Cascade","Drug resistance of KIT mutants","Leishmania parasite growth and survival","Transcriptional regulation by RUNX1","RHO GTPases act
ivate PKNs","HIV Life Cycle","VEGF ligand-receptor interactions","Toll Like Receptor 5 (TLR5) Cascade","Insulin receptor signalling cascade","Caspase activation via Dependence Receptors in the absence
 of ligand","G2/M Transition","Negative regulation of the PI3K/AKT network","Oxidative Stress Induced Senescence","G alpha (i) signalling events","PTEN Regulation","PTK6 promotes HIF1A stabilization",
"Signalling to ERKs","VEGFR2 mediated cell proliferation","Regulation of TP53 Activity","IRS-related events triggered by IGF1R","Activation of TRKA receptors","Signaling by FGFR3 point mutants in canc
er","Cyclin D associated events in G1","Leishmania phagocytosis","ISG15 antiviral mechanism","Activated NTRK3 signals through PI3K","Interleukin-15 signaling","FGFR1 mutant receptor activation","Traff
icking of AMPA receptors","The role of Nef in HIV-1 replication and disease pathogenesis","Mitotic Anaphase","Sema4D in semaphorin signaling","MyD88-independent TLR4 cascade","Dasatinib-resistant KIT 
mutants","Anti-inflammatory response favouring Leishmania parasite infection","RUNX1 regulates transcription of genes involved in BCR signaling","Late Phase of HIV Life Cycle","VEGF binds to VEGFR lea
ding to receptor dimerization","MyD88 cascade initiated on plasma membrane","IRS-mediated signalling","Centrosome maturation",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","Visual phototransduction
","Regulation of PTEN stability and activity","Signalling to RAS","Regulation of TP53 Activity through Phosphorylation","NGF-independant TRKA activation","FGFR3 mutant receptor activation","FCGR3A-med
iated phagocytosis","Prolonged ERK activation events","Signaling by activated point mutants of FGFR1","Trafficking of GluR2-containing AMPA receptors","Nef and signal transduction","Separation of Sist
er Chromatids","Sema4D mediated inhibition of cell attachment and migration","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3A-mediated IL10 synthesis","Transcription of the HIV genome","MAP kinase activ
ation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","PI3K Cascade","Loss of proteins required for interphase microtubule organization from the centr
osome","The phototransduction cascade","p38MAPK events","Signaling by activated point mutants of FGFR3","ARMS-mediated activation","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","HIV Transcrip
tion Elongation","MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","Loss of Nlp from mitotic centrosomes",Inactivation,"recovery and regulation of the phototran
sduction cascade","Tat-mediated elongation of the HIV-1 transcript","CREB phosphorylation","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{1108743-60-7,1108743607,"1108743 60 7",NMS-E628,NMSE628,"NMS E628",RXDX-101,RXDX101,"RXDX 101","Entrectinib (RXDX-101)","Entrectinib (RXDX101)","Entrectinib (RXDX 101)",Rozlytrek,UNII-L5ORF0AN1I,UNII
L5ORF0AN1I,"UNII L5ORF0AN1I",L5ORF0AN1I,"Entrectinib (USAN:INN)","Rozlytrek (TN)",YMX,"Entrectinib, 95",Kinome_2659,Kinome2659,Kinome-2659,"Kinome 2659",Entrectinib(rxdx-101),Entrectinib(rxdx101),"Ent
rectinib(rxdx 101)","Entrectinib; NMS-E628","Entrectinib; NMSE628","Entrectinib; NMS E628","Entrectinib (JA",T3678,Entrectinib}

> <pdid>
PD012826

> <targets>
{"Trk receptor",ALK,ROS1,TrkA,TrkB,TrkC,Autophagy,ROS,"Trk Receptor"}

> <classes>
{Angiogenesis,Immunology/Inflammation,Tyrosine Kinase/Adaptors,Autophagy,Neuronal Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{25141092}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 33  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 S   0  0
   -2.6016   -2.9971    0.0000 O   0  0
   -1.3015   -2.2494    0.0000 O   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -0.0095   -6.0029    0.0000 C   0  0
   -0.0126   -7.5029    0.0000 C   0  0
   -1.3132   -8.2502    0.0000 C   0  0
   -1.3193   -9.7510    0.0000 N   0  0
   -2.6217  -10.4969    0.0000 C   0  0
   -3.9179   -9.7420    0.0000 O   0  0
   -2.6279  -11.9977    0.0000 C   0  0
   -3.9302  -12.7436    0.0000 C   0  0
   -3.9364  -14.2444    0.0000 C   0  0
   -5.1517  -15.1017    0.0000 S   0  0
   -4.6911  -16.5293    0.0000 C   0  0
   -3.1911  -16.5324    0.0000 C   0  0
   -2.7246  -15.1068    0.0000 C   0  0
   -5.5717  -17.7414    0.0000 N   0  3
   -7.0635  -17.5842    0.0000 O   0  5
   -4.9625  -19.1121    0.0000 O   0  0
   -2.6106   -7.4975    0.0000 C   0  0
   -2.6076   -5.9975    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  2  0
 10 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 22  2  0
 24 27  1  0
 27 28  1  0
 27 29  2  0
 16 30  1  0
 30 31  2  0
 31 13  1  0
M  CHG  2  27   1  28  -1
M  END
> <name>
UTKinase_V5

> <id>
28907

> <plate>
Kinase v5-3

> <well>
B03

> <supplier_cmpd_name>
Necrosulfonamide

> <ctcr_id>
8265

> <supplier_cmpd_id>
S8251

> <smiles>
COc1nccnc1N[S](=O)(=O)c2ccc(NC(=O)/C=C/c3sc(cc3)[N+]([O-])=O)cc2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{1360614-48-7,Necrosulfonamid,CHEBI:63770,(Z)-Necrosulfonamide,"Necrosulfonamide (NSA)",CHEMBL3220918,SCHEMBL17509589,SCHEMBL17509590,DTXSID00364437,BCP18373,BCP25934,ZINC1774964,MFCD02370191,s8251,ST
L429797,AKOS002349391,CCG-269351,BS-17282,Q27132789,T6904,20844,Necrosulfonamide,necrosulfonamide}

> <pdid>
PD003384

> <targets>
{Others,"Mixed Lineage Kinase"}

> <classes>
{MAPK/ERK Pathway}

> <pubchem_cids>
{1566236}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 35  0  0  1  0            999 V2000
    5.1855   -6.0062    0.0000 O   0  0
    6.4870   -5.2605    0.0000 C   0  0
    7.7840   -6.0157    0.0000 N   0  0
    7.7795   -7.5165    0.0000 C   0  0
    9.0758   -8.2712    0.0000 C   0  0
    6.4915   -3.7597    0.0000 N   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0  1  0  0  0
    2.5981    3.0050    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.7059   -1.4069    0.0000 C   0  0
   -1.7046   -2.3132    0.0000 C   0  0
   -3.6065    0.0000    0.0000 S   0  0
   -4.0934   -0.8734    0.0000 O   0  0
   -4.3371    1.3100    0.0000 O   0  0
   -2.7248    1.2135    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  2  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  6
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 14  1  0
 13 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
 26 27  2  0
 26 28  2  0
 26 29  1  0
 29 21  1  0
 22 30  2  0
 30 11  1  0
 10 31  1  0
 31 32  2  0
 32  7  1  0
M  END
> <name>
UTKinase_V5

> <id>
28908

> <plate>
Kinase v5-3

> <well>
B05

> <supplier_cmpd_name>
CZ415

> <ctcr_id>
12406

> <supplier_cmpd_id>
S8298

> <smiles>
O=C(NCC)Nc1ccc(c2nc(N3[C@@H](C)COCC3)c3c(C(C)(C)S(=O)(=O)C3)n2)cc1

> <pd_targets>
{MTOR,MAPKAP1,MLST8,RICTOR,KCNH2,RPTOR}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","Atypical protein kinase group","Voltage-gated potassium channel","Atypical protein kinase PIKK family","
Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Ion channels","Kinases (EC 2.7.x.x)","Voltage-gated ion channels",Atypical,"Potassium channels","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Voltage-gated potassium chann
els","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Muscle contraction","RNA Polymerase II Transcription","Cardiac conduction","Generic Transcription Pathway","Phase 3 - rapid repolarisation","Transcriptional Regulat
ion by TP53","Regulation of TP53 Activity","Regulation of TP53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{CZ415,1429639-50-8,1429639508,CHEMBL4577549,CZ-415,SCHEMBL14852676,BCP20204,EX-A1459,EXA1459,BDBM50535043,s8298,ZINC143379751,CCG-269328,CCG269328,CS-6131,CS6131,SB18770,AC-31530,AC31530,BS-15397,BS1
5397,HY-100222,HY100222,T3514}

> <pdid>
PD065109

> <targets>
{mTOR}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{71547699}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 41  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.1961   -1.5000    0.0000 O   0  0
   -2.5981   -1.5000    0.0000 N   0  0
   -2.6011   -3.0008    0.0000 C   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -3.9050   -5.2502    0.0000 C   0  0
   -5.2059   -5.9988    0.0000 N   0  0
   -5.2111   -7.4988    0.0000 C   0  0
   -6.5128   -8.2443    0.0000 C   0  0
   -7.8092   -7.4898    0.0000 N   0  0
   -7.8040   -5.9899    0.0000 C   0  0
   -6.5024   -5.2443    0.0000 C   0  0
   -9.1131   -8.2331    0.0000 C   0  0
   -9.1209   -9.7331    0.0000 O   0  0
  -10.4091   -7.4763    0.0000 C   0  0
  -11.7123   -8.2192    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -3.9015    3.7525    0.0000 Cl  0  0
   -6.4995    3.7483    0.0000 C   0  0
   -6.5050    5.2492    0.0000 O   0  0
   -7.8063    5.9952    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -9.0951    0.7464    0.0000 O   0  0
  -10.3943    1.4962    0.0000 C   0  0
   -6.4948    0.7483    0.0000 C   0  0
   -6.4924   -0.7517    0.0000 Cl  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 15  1  0
 18 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  2  0
 11 25  1  0
 25  6  1  0
 25 26  2  0
 26  3  1  0
  8 27  1  0
 27 28  2  0
 28 29  1  0
 28 30  1  0
 30 31  1  0
 31 32  1  0
 30 33  2  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 34 37  2  0
 37 27  1  0
 37 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28912

> <plate>
Kinase v5-3

> <well>
B13

> <supplier_cmpd_name>
PRN1371

> <ctcr_id>
14956

> <supplier_cmpd_id>
S8578

> <smiles>
CNc1ncc2C=C(C(=O)N(CCCN3CCN(CC3)C(=O)C=C)c2n1)c4c(Cl)c(OC)cc(OC)c4Cl

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HY-101768,PRN1371,PRN1371}

> <pdid>
PD076543

> <targets>
{FGFR,c-Fms}

> <classes>
{Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 26  0  0  0  0            999 V2000
    7.8580    5.3610    0.0000 N   0  0
    6.4185    4.9394    0.0000 C   0  0
    4.9781    4.5176    0.0000 C   0  0
    4.6234    3.0602    0.0000 C   0  0
    3.1884    2.6409    0.0000 C   0  0
    2.0990    3.6745    0.0000 C   0  0
    2.4537    5.1320    0.0000 C   0  0
    3.8933    5.5535    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  3  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  5  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13  9  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 14 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28915

> <plate>
Kinase v5-3

> <well>
D19

> <supplier_cmpd_name>
PF-06447475

> <ctcr_id>
11439

> <supplier_cmpd_id>
S8202

> <smiles>
N#Cc1cc(ccc1)c1c[nH]c2c1c(ncn2)N1CCOCC1

> <pd_targets>
{LRRK2,STK3,STK26}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","STE protein kinase group","TKL protein kinase LRRK family","STE protein kinase STE20 family","STE protein kinase MST subfamily","STE protein
 kinase YSK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","TKL: Tyrosine kinase-like","STE20 family","Leuc
ine-rich repeat kinase (LRRK) family","MST subfamily","YSK subfamily"}

> <pathway_reactome>
{"Signal Transduction","Programmed Cell Death","Signaling by Non-Receptor Tyrosine Kinases","Signaling by Hippo",Apoptosis,"Signaling by PTK6","Apoptotic execution phase","PTK6 promotes HIF1A stabiliz
ation","Apoptotic cleavage of cellular proteins"}

> <broad_targets>
{LRRK2}

> <broad_moa>
{"serine/threonine kinase inhibitor"}

> <synonyms>
{F0644747,PF-06447475,PF06447475,1527473-33-1,1527473331,"3-(4-morpholino-7H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile","3(4morpholino7Hpyrrolo(2,3d)pyrimidin5yl)benzonitrile","3-(4-(morpholin-4-yl)-7
H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile","3(4(morpholin4yl)7Hpyrrolo(2,3d)pyrimidin5yl)benzonitrile",CHEMBL3393348,"PF 06447475",3FE,GTPL8054,SCHEMBL15401353,AOB5482,EX-A560,EXA560,BC,T2050}

> <pdid>
PD012846

> <targets>
{LRRK2,"G2019S LRRK2"}

> <classes>
{Autophagy}

> <pubchem_cids>
{72706840}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -5.1961   -3.0000    0.0000 C   0  0
   -5.1962   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28916

> <plate>
Kinase v5-3

> <well>
D21

> <supplier_cmpd_name>
NU7026

> <ctcr_id>
1942

> <supplier_cmpd_id>
S2893

> <smiles>
O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

> <pd_targets>
{RORC,PRKDC,MTOR,PIK3R1,PIK3CA}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Nuclear receptor",Kinase,Transferase,"Nuclear hormone receptor subfamily 1","Protein Kinase","Nuclear hormone receptor subfamily 1 group F","Atypical protein kinase gro
up","Nuclear hormone receptor subfamily 1 group F member 3","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Kinases (EC 2.7.x.x)","Glycerophospholipid turnover","1F. Retinoic acid-related orphans",Atypical,"Phosphatidylinositol kinases","Lipid modifying kinase
s","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Other PIKK family kinases","FRAP subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Immune System",Disease,"RNA Polymerase II Transcription","Innate Immune System","Diseases of signal transduction by growth factor receptors and second messengers","
Generic Transcription Pathway","Cytosolic sensors of pathogen-associated DNA","Signaling by FGFR in disease","Transcriptional regulation by RUNX3","STING mediated induction of host immune responses","
Transcriptional Regulation by TP53","Signaling by FGFR1 in disease","RUNX3 Regulates Immune Response and Cell Migration","IRF3-mediated induction of type I IFN","Regulation of TP53 Activity","FGFR1 mu
tant receptor activation","Regulation of TP53 Expression and Degradation","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
{PRKDC}

> <broad_moa>
{"DNA dependent protein kinase inhibitor","mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{DJ7RQT66H6,cc-674,cc674,154447-35-5,154447355,NU7026,"NU 7026",NU-7026,"DNA-PK Inhibitor II","DNAPK Inhibitor II",2-(Morpholin-4-yl)-benzo(h)chromen-4-one,2(Morpholin4yl)benzo(h)chromen4one,2-morphol
ino-4H-benzo(h)chromen-4-one,2morpholino4Hbenzo(h)chromen4one,2-morpholin-4-ylbenzo(h)chromen-4-one,2morpholin4ylbenzo(h)chromen4one,LY293646,2-(4-morpholinyl)-4H-naphtho(1,2(4morpholinyl)4Hnaphtho(1,
2-b)pyran-,2b)pyran,T2433,"EMD 260961",2828,260961}

> <pdid>
PD012539

> <targets>
{DNA-PK}

> <classes>
{}

> <pubchem_cids>
{9860529}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 29  0  0  1  0            999 V2000
    3.8978   -2.2504    0.0000 N   0  0
    2.5988   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -7.7980    1.4850    0.0000 N   0  0
   -7.8010    2.9858    0.0000 C   0  0
   -9.1018    3.7344    0.0000 C   0  0  1  0  0  0
   -9.1071    5.2344    0.0000 C   0  0
  -10.4087    5.9799    0.0000 N   0  0
  -11.7052    5.2255    0.0000 C   0  0
  -11.7000    3.7255    0.0000 C   0  0
  -10.3984    2.9800    0.0000 O   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 N   0  0
   -7.7891   -1.5185    0.0000 C   0  0
   -9.0912   -0.7738    0.0000 F   0  0
   -7.7834   -3.0185    0.0000 F   0  0
   -9.0852   -2.2736    0.0000 F   0  0
  1  2  3  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  6  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 15 14  1  6
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 15  1  0
 12 21  2  0
 21 22  1  0
 22 23  2  0
 23 10  1  0
 21 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28917

> <plate>
Kinase v5-3

> <well>
D03

> <supplier_cmpd_name>
CCT245737

> <ctcr_id>
13528

> <supplier_cmpd_id>
S8253

> <smiles>
N#Cc1ncc(nc1)Nc3cc(NC[C@H]2CNCCO2)c(cn3)C(F)(F)F

> <pd_targets>
{CHEK1,CHEK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CAMK protein kinase CAMK1 family","CAMK protein kinase RAD53 family","CAMK protein kinase CHK1 subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","CAMK-like (CAMKL) family","CHK1 subfamily"}

> <pathway_reactome>
{"DNA Repair","Gene expression (Transcription)","DNA Double-Strand Break Repair","RNA Polymerase II Transcription","Homology Directed Repair","Generic Transcription Pathway","HDR through Homologous Re
combination (HRR) or Single Strand Annealing (SSA)","Transcriptional Regulation by TP53","HDR through Homologous Recombination (HRR)","Regulation of TP53 Activity","Homologous DNA Pairing and Strand E
xchange","Regulation of TP53 Expression and Degradation","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Degradation"}

> <broad_targets>
{}

> <broad_moa>
{"kinase inhibitor"}

> <synonyms>
{CCT245737,1489389-18-5,CCT-245737,GTPL9187,SRA737,CHEMBL4169078,SCHEMBL15392098,"US9663503, Compound 1",BDBM328993,"SRA737; PNT-737",EX-A1607,MFCD30489721,NSC793726,ZINC205442186,CCG-268393,"compound
 4 (PMID: 27167172)",CS-5863,NSC-793726,SB19177,BS-15458,HY-18958,J3.603.159J,Q27075794,T7080}

> <pdid>
PD047198

> <targets>
{Chk1}

> <classes>
{"Cell Cycle/Checkpoint"}

> <pubchem_cids>
{72165232}

$$$$
UTKinase_V5
  SciTegic11012413002D

 19 21  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -5.1968   -1.5004    0.0000 C   0  0
   -6.4971   -0.7525    0.0000 C   0  0
   -7.7950   -1.5046    0.0000 C   0  0
   -7.7926   -3.0046    0.0000 C   0  0
   -6.4923   -3.7525    0.0000 C   0  0
   -5.1945   -3.0005    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11  5  1  0
 11 12  2  0
 12  2  1  0
 12 13  1  0
  9 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
M  END
> <name>
UTKinase_V5

> <id>
28918

> <plate>
Kinase v5-3

> <well>
D05

> <supplier_cmpd_name>
7,8-Dihydroxyflavone

> <ctcr_id>
3285

> <supplier_cmpd_id>
S8319

> <smiles>
Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{8DIHYDROXYFLAVON,"7,8-dihydroxyflavone","7,8dihydroxyflavone",38183-03-8,38183038,"7,8-dihydroxy-2-phenyl-4H-chromen-4-one","7,8dihydroxy2phenyl4Hchromen4one","7,8-DHF","7,8DHF","4H-1-Benzopyran-4-on
e, 7,8-dihydroxy-2-phenyl-","4H1Benzopyran4one, 7,8dihydroxy2phenyl","7,8-Dihydroxy-flavone","7,8Dihydroxyflavone","7,8-Dihydroxy-2-phenyl-chromen-4-one","7,8Dihydroxy2phenylchromen4one","7,8-Dihydrox
yflavone hydrate","7,8Dihydroxyflavone hydrate",7,8-D,8D,T2816,201315,"7,8-Dihydroxyflavone","7,8-DIHYDROXYFLAVONE"}

> <pdid>
PD002189

> <targets>
{"Trk receptor"}

> <classes>
{antihaemorrhagic,"vascular protectant"}

> <pubchem_cids>
{1880}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 27  0  0  1  0            999 V2000
   -0.6923   -4.0811    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -2.6030    2.9977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 N   0  0
   -4.0317   -0.7359    0.0000 C   0  0
   -5.4979   -1.0529    0.0000 C   0  0
   -6.2524    0.2436    0.0000 C   0  0
   -5.2526    1.3618    0.0000 C   0  0  1  0  0  0
   -5.5610    2.8305    0.0000 C   0  0
   -4.5297    3.9126    0.0000 C   0  0
   -4.9536    5.3514    0.0000 C   0  0
   -6.4116    5.7038    0.0000 C   0  0
   -6.8355    7.1427    0.0000 Cl  0  0
   -7.4458    4.6173    0.0000 C   0  0
   -7.0219    3.1784    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  2  1  0
 10  5  1  0
  8 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 13  1  0
 17 18  1  1
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28919

> <plate>
Kinase v5-3

> <well>
D07

> <supplier_cmpd_name>
MSC2530818

> <ctcr_id>
14908

> <supplier_cmpd_id>
S8387

> <smiles>
Cc1n[nH]c2ncc(cc12)C(=O)N3CCC[C@H]3c4ccc(Cl)cc4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HY-101611,MSC2530818,MSC2530818}

> <pdid>
PD063773

> <targets>
{CDK}

> <classes>
{Cell Cycle/DNA Damage}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    5.1009    2.6017    0.0000 O   0  0
    5.8532    1.3040    0.0000 C   0  0
    5.1047    0.0031    0.0000 N   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    2.7248    1.2135    0.0000 S   0  0
    7.3541    1.3071    0.0000 C   0  0
    8.1026    2.6079    0.0000 C   0  0
    9.6026    2.6133    0.0000 C   0  0
   10.3481    3.9149    0.0000 C   0  0
    9.5936    5.2113    0.0000 C   0  0
   10.3421    6.5121    0.0000 O   0  0
   11.8421    6.5152    0.0000 C   0  0
    8.0936    5.2061    0.0000 C   0  0
    7.3360    6.5017    0.0000 O   0  0
    5.8360    6.4943    0.0000 C   0  0
    7.3481    3.9045    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
  7 16  1  0
 16  4  1  0
  2 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 21 24  1  0
 24 25  1  0
 25 26  1  0
 24 27  2  0
 27 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28920

> <plate>
Kinase v5-3

> <well>
D09

> <supplier_cmpd_name>
ZINC00881524 (ROCK inhibitor)

> <ctcr_id>
11659

> <supplier_cmpd_id>
S8448

> <smiles>
O=C(Nc1nc2c(CCc3c2cccc3)s1)Cc1ccc(OC)c(OC)c1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{ZINC00881524,557782-81-7,557782817,"N-(4,5-dihydronaphtho(1,2-d)thiazol-2-yl)-2-(3,4-dimethoxyphenyl)acetamide","N(4,5dihydronaphtho(1,2d)thiazol2yl)2(3,4dimethoxyphenyl)acetamide","ZINC00881524 (ROC
K inhibitor)",ZINC881524,BCP25184,EX-A1504,EXA1504,s8448,AKOS001072293,ZINC-00881524,CCG-268409,CCG268409,CS-6520,CS6520,MCULE-2808610865,MCULE2808610865,BS-17128,BS17128,T4095}

> <pdid>
PD063701

> <targets>
{ROCK}

> <classes>
{"Cell Cycle/Checkpoint","Stem Cells"}

> <pubchem_cids>
{1138914}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 46  0  0  1  0            999 V2000
    4.8036   -3.1167    0.0000 O   0  0
    4.0559   -4.4171    0.0000 C   0  0
    2.5551   -4.4192    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 N   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -7.7891   -1.5185    0.0000 C   0  0
   -7.7834   -3.0185    0.0000 C   0  0
   -9.0912   -0.7738    0.0000 O   0  0
   -9.0852   -2.2736    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 N   0  0
   -0.6928   -4.0817    0.0000 C   0  0  1  0  0  0
   -2.1743   -3.8808    0.0000 C   0  0
   -3.0913   -5.0679    0.0000 C   0  0
   -2.5218   -6.4556    0.0000 C   0  0  1  0  0  0
   -3.4369   -7.6452    0.0000 C   0  0
   -2.8651   -9.0328    0.0000 N   0  0
   -3.7801  -10.2224    0.0000 C   0  0
   -3.2086  -11.6093    0.0000 C   0  0
   -5.2670  -10.0244    0.0000 C   0  0
   -4.9237   -7.4471    0.0000 O   0  0
   -1.0353   -6.6562    0.0000 C   0  0
   -0.1183   -5.4691    0.0000 C   0  0
    4.8090   -5.7153    0.0000 C   0  0
    6.3090   -5.7153    0.0000 C   0  0
    7.0591   -7.0143    0.0000 C   0  0
    6.3091   -8.3134    0.0000 C   0  0
    7.0592   -9.6124    0.0000 F   0  0
    4.8091   -8.3134    0.0000 C   0  0
    4.0591   -7.0144    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 15 17  1  0
 15 18  1  0
 14 19  1  0
 19 20  1  0
 20 11  1  0
  9 21  1  0
 21 22  2  3
 22  6  1  0
 22 23  1  0
 23  4  1  0
 24 23  1  6
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  6
 28 29  1  0
 29 30  1  0
 30 31  1  0
 30 32  1  0
 28 33  2  0
 27 34  1  0
 34 35  1  0
 35 24  1  0
  2 36  1  0
 36 37  2  3
 37 38  1  0
 38 39  2  3
 39 40  1  0
 39 41  1  0
 41 42  2  3
 42 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
28921

> <plate>
Kinase v5-3

> <well>
D11

> <supplier_cmpd_name>
Belizatinib (TSR-011)

> <ctcr_id>
12624

> <supplier_cmpd_id>
S8511

> <smiles>
O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"receptor tyrosine protein kinase inhibitor"}

> <synonyms>
{"Belizatinib (WHO-DD)","Belizatinib (WHODD)",Belizatinib(TSR-011),Belizatinib(TSR011),"TSR-011 (Belizatinib)","TSR011 (Belizatinib)",Belizatinib,1357920-84-3,1357920843,"Belizatinib (TSR011)",TSR-011
,TSR011,UNII-Z8A6022P3J,UNIIZ8A6022P3J,CHEMBL2172308,Z8A6022P3J,"Belizatinib (INN)","Belizatinib (TSR-011)",SCHEMBL573248,SCHEMBL573249,T4257,T4283,SRI-011381}

> <pdid>
PD086857

> <targets>
{ALK,Trk Receptor}

> <classes>
{Tyrosine Kinase/Adaptors,Neuronal Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{57345941}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 31  0  0  0  0            999 V2000
    5.6590    1.8298    0.0000 C   0  0
    7.1272    2.1369    0.0000 C   0  0
    7.5954    3.5619    0.0000 O   0  0
    6.5954    4.6799    0.0000 C   0  0
    5.1271    4.3729    0.0000 C   0  0
    4.6588    2.9478    0.0000 N   0  0
    3.1904    2.6376    0.0000 C   0  0
    2.1885    3.7539    0.0000 O   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -6.3152    3.9975    0.0000 O   0  0
   -5.7073    5.3688    0.0000 C   0  0
   -4.2152    5.2143    0.0000 N   0  0
   -6.4593    6.6666    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13  9  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 12  1  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 18  1  0
 21 24  1  0
 24 25  1  0
 25 26  2  0
 26 20  1  0
 25 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28922

> <plate>
Kinase v5-3

> <well>
D13

> <supplier_cmpd_name>
Serabelisib (INK-1117,MLN-1117,TAK-117)

> <ctcr_id>
12202

> <supplier_cmpd_id>
S8581

> <smiles>
C1COCCN1C(=O)c1cnc2n1cc(cc2)c1cc2c(cc1)oc(n2)N

> <pd_targets>
{MTOR,PIK3CG,PIK3CD,PIK3CB,PIK3CA}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Lipid modifying kinases","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","FRAP subfami
ly"}

> <pathway_reactome>
{"Gene expression (Transcription)",Metabolism,"Immune System","Signal Transduction",Disease,"RNA Polymerase II Transcription","Metabolism of lipids","Cytokine Signaling in Immune system","Signaling by
 Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Generic Transcription Pathway","Phospholipid metabolism","Signaling by Interleukins","Si
gnaling by Insulin receptor","Signaling by FGFR in disease","Transcriptional Regulation by TP53","PI Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade
","Signaling by FGFR1 in disease","Regulation of TP53 Activity","Synthesis of PIPs at the plasma membrane","Interleukin receptor SHC signaling","IRS-mediated signalling","FGFR1 mutant receptor activat
ion","Regulation of TP53 Expression and Degradation","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
{PIK3CA}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{Serabelisib,1268454-23-4,1268454234,MLN1117,MLN-1117,INK-1117,INK1117,TAK-117,TAK117,AGN-PC-0DB6FL,AGNPC0DB6FL,UNII-43J9Q56T3W,UNII43J9Q56T3W,43J9Q56T3W,"Serabelisib (INN)","MLN1117 (INK1117)","Serab
elisib (INK-1117,MLN-1117,TAK-117)","Serabelisib (INK1117,MLN1117,TAK117)",GTPL8969,CHEMBL3935857,SCHEMBL12928418,BDBM119531,BCP,T3153}

> <pdid>
PD016972

> <targets>
{PI3K,mTOR,p110¦Á,p110¦Â,p110¦Ã,p110¦Ä}

> <classes>
{"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{70798655}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 30  0  0  1  0            999 V2000
    2.4298   -5.7148    0.0000 C   0  0
    0.9385   -5.5534    0.0000 N   0  0
    3.9219   -5.8762    0.0000 C   0  0
    4.8085   -4.6653    0.0000 C   0  0  2  0  0  0
    6.3008   -4.8250    0.0000 C   0  0
    7.2881   -3.7128    0.0000 C   0  0
    8.6555   -4.3295    0.0000 C   0  0
    8.4915   -5.8205    0.0000 C   0  0
    7.0228   -6.1253    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   12.4555   -2.3127    0.0000 P   0  0
   11.1562   -3.0622    0.0000 O   0  0
   13.7548   -3.0622    0.0000 O   0  0
   12.4555   -0.8127    0.0000 O   0  0
   12.4555   -3.8127    0.0000 O   0  0
  1  2  3  0
  1  3  1  0
  4  3  1  1
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9  5  1  0
  4 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 10  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 19  1  0
 24 25  2  0
 24 26  1  0
 24 27  1  0
 24 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28923

> <plate>
Kinase v5-3

> <well>
D15

> <supplier_cmpd_name>
Ruxolitinib Phosphate

> <ctcr_id>
11041

> <supplier_cmpd_id>
S5243

> <smiles>
C(#N)C[C@H](C1CCCC1)n1ncc(c1)c1ncnc2c1cc[nH]2.P(=O)(O)(O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Ruxolitinib phosphate",1092939-17-7,1092939177,Jakafi,Jakavi,"Ruxolitinib (phosphate)","Ruxolitinib phosphate salt",UNII-436LRU32H5,UNII436LRU32H5,"INCB018424 SALT",CHEBI:66917,436LRU32H5,"1092939-1
7-7 (phosphate)","1092939177 (phosphate)",INC-424,INC424,INCB-18424,INCB18424,"INCB 018424 phosphate",T3043,"Ruxolitinib (INCB-18424) phosphate"}

> <pdid>

> <targets>
{JAK,JAK1,JAK2}

> <classes>
{Angiogenesis,Chromatin/Epigenetic,"JAK/STAT signaling","Stem Cells"}

> <pubchem_cids>
{25127112}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 33  0  0  1  0            999 V2000
   -4.5468    6.8759    0.0000 O   0  0
   -4.5738    5.3762    0.0000 C   0  0
   -5.8863    4.6501    0.0000 O   0  0
   -3.2882    4.6017    0.0000 C   0  0
   -3.3152    3.1011    0.0000 C   0  0
   -2.0297    2.3266    0.0000 C   0  0
   -2.0567    0.8260    0.0000 C   0  0
   -0.8100    0.0300    0.0000 C   0  0  1  0  0  0
   -0.7985   -1.4700    0.0000 C   0  0
   -0.8100    1.5100    0.0000 O   0  0
    0.5500    2.3600    0.0000 C   0  0
    0.5708    3.8599    0.0000 O   0  0
    1.9200    1.4500    0.0000 C   0  0  1  0  0  0
    0.3800    1.8800    0.0000 C   0  0
   -0.6100    0.6500    0.0000 C   0  0
    0.6400   -0.8800    0.0000 C   0  0  2  0  0  0
    1.9200    0.0000    0.0000 C   0  0  1  0  0  0
    3.0900   -1.0200    0.0000 C   0  0
    4.6300   -0.6600    0.0000 C   0  0
    5.2400    0.7200    0.0000 C   0  0
    4.6300    1.9300    0.0000 C   0  0
    3.1900    2.3600    0.0000 C   0  0
    6.7406    0.8138    0.0000 C   0  0
    7.5706   -0.4356    0.0000 O   0  0
    7.4084    2.1579    0.0000 O   0  0
    8.9054    2.2524    0.0000 C   0  0
    0.6493    0.7959    0.0000 C   0  0
   -0.6737    0.0889    0.0000 O   0  0
    0.6980    2.2959    0.0000 O   0  0
   -0.5754    3.0886    0.0000 C   0  0
   -1.9757    5.3277    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  6
  8 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  1
 14 15  1  0
 16 15  1  1
 16  8  1  0
 16 17  1  0
 17 13  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  3
 21 22  1  0
 22 13  1  0
 20 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  1  0
 17 27  1  1
 27 28  2  0
 27 29  1  0
 29 30  1  0
  4 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28924

> <plate>
Kinase v5-3

> <well>
D17

> <supplier_cmpd_name>
Pseudolaric Acid B

> <ctcr_id>
11460

> <supplier_cmpd_id>
S5373

> <smiles>
O=C(O)/C(=C/C=C/[C@@]1(C)OC(=O)[C@@]23CC[C@@H]1[C@]2(CCC(=CC3)C(=O)OC)C(=O)OC)/C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"HSDB 8110",ZINC33953227,AKOS015897130,AC-6065,AC6065,3B1-008274,3B1008274,T1922,"Pseudolaric Acid B"}

> <pdid>
PD098564

> <targets>
{p38,Apoptosis,Autophagy,Ferroptosis,Fungal,HBV}

> <classes>
{MAPK,Anti-infection,Apoptosis,Autophagy}

> <pubchem_cids>
{6436202}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 20  0  0  0  0            999 V2000
    2.6000    0.0000    0.0000 S   0  0
    2.6000   -1.5000    0.0000 O   0  0
    1.3011   -0.7502    0.0000 O   0  0
    1.3000    0.7500    0.0000 O   0  0
    0.0007    0.0004    0.0000 Na  0  0
    3.9000    0.7500    0.0000 C   0  0
    5.2000    0.0000    0.0000 C   0  0
    5.2000   -1.5000    0.0000 O   0  0
    6.5000    0.7500    0.0000 O   0  0
    7.7999    0.0000    0.0000 C   0  0
    9.0999    0.7500    0.0000 C   0  0
   10.3999    0.0000    0.0000 C   0  0
   11.6999    0.7500    0.0000 C   0  0
   12.9999    0.0000    0.0000 C   0  0
   14.2999    0.7500    0.0000 C   0  0
   15.5999    0.0000    0.0000 C   0  0
   16.8999    0.7500    0.0000 C   0  0
   18.1999    0.0000    0.0000 C   0  0
   19.4998    0.7500    0.0000 C   0  0
   20.7998    0.0000    0.0000 C   0  0
   22.0991    0.7496    0.0000 C   0  0
  1  2  2  0
  1  3  2  0
  1  4  1  0
  4  5  1  0
  1  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28926

> <plate>
Kinase v5-3

> <well>
F21

> <supplier_cmpd_name>
Sodium Houttuyfonate

> <ctcr_id>
12348

> <supplier_cmpd_id>
S3801

> <smiles>
S(=O)(=O)(O([Na]))CC(=O)OCCCCCCCCCCCC

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Sodium lauryl sulfoacetate",1847-58-1,1847581,Lathanol,"Lathanol LAL","Nacconol LAL","Acetic acid, sulfo-, 1-dodecyl ester, sodium salt","Acetic acid, sulfo, 1dodecyl ester, sodium salt",UNII-D0Y70F
2B9J,UNIID0Y70F2B9J,"Sodium 2-(dodecyloxy)-2-oxoethane-1-sulphonate","Sodium 2(dodecyloxy)2oxoethane1sulphonate","Sulfoacetic acid dodecyl ester S-sod","Sulfoacetic acid dodecyl ester Ssod",T3603,"Sod
ium houttuyfonate"}

> <pdid>

> <targets>
{MAPKs,NF-¦ÊB}

> <classes>
{MAPK,NF-¦ªb}

> <pubchem_cids>
{23668827}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  0  0            999 V2000
    2.5983   -3.0004    0.0000 O   0  0
    2.5988   -1.5004    0.0000 S   0  0
    1.2996   -2.2502    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.6011   -3.0008    0.0000 N   0  0
   -3.9020   -3.7494    0.0000 C   0  0
   -5.2513   -3.1239    0.0000 N   0  0
   -6.2587   -4.2353    0.0000 N   0  0
   -5.5132   -5.5360    0.0000 C   0  0
   -4.0449   -5.2290    0.0000 C   0  0
   -3.0449   -6.3470    0.0000 C   0  0
   -3.5132   -7.7721    0.0000 C   0  0
   -2.5132   -8.8901    0.0000 F   0  0
   -4.9814   -8.0791    0.0000 C   0  0
   -5.9814   -6.9611    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8990   -0.7508    0.0000 C   0  0
    5.1981   -1.5008    0.0000 C   0  0
    3.8995    0.7492    0.0000 C   0  0
    5.1982   -0.0010    0.0000 C   0  0
  1  2  2  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 13  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 22 16  1  0
 11 23  1  0
 23  7  1  0
 23 24  2  0
 24  4  1  0
  2 25  1  0
 25 26  1  0
 25 27  1  0
 25 28  1  0
M  END
> <name>
UTKinase_V5

> <id>
28927

> <plate>
Kinase v5-3

> <well>
F03

> <supplier_cmpd_name>
GSK583

> <ctcr_id>
11971

> <supplier_cmpd_id>
S8261

> <smiles>
O=S(=O)(c1ccc2nccc(Nc3n[nH]c4c3cc(F)cc4)c2c1)C(C)(C)C

> <pd_targets>
{RIPK2,MAPK14,GAK,TGFBR1,LCK,RIPK3,GSC2,KCNH2}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,Transferase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","TKL protein kinase group","CMGC protein kinase group","Other protein kinase group","TK prote
in kinase group","Voltage-gated potassium channel","TKL protein kinase RIPK family","CMGC protein kinase MAPK family","Other protein kinase NAK family","TKL protein kinase STKR family","Tyrosine prote
in kinase Src family","CMGC protein kinase p38 subfamily","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Ion channels","Catalytic receptors","Kinases (EC 2.7.x.x)","Voltage-gated ion channels","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Potassium channels","TKL
: Tyrosine kinase-like","Mitogen-activated protein kinases (MAP kinases)","Other protein kinases","TK: Tyrosine kinase","Voltage-gated potassium channels","Receptor interacting protein kinase (RIPK) f
amily","p38 subfamily","Numb-associated kinase (NAK) family","Receptor serine/threonine kinase (RSTK) family","Non-receptor tyrosine kinases (nRTKs)","Type I receptor serine/threonine kinases","Src fa
mily"}

> <pathway_reactome>
{"Immune System","Vesicle-mediated transport",Disease,"Muscle contraction","Innate Immune System","Membrane Trafficking","Diseases of signal transduction by growth factor receptors and second messenge
rs","Infectious disease","Cardiac conduction","Toll-like Receptor Cascades","trans-Golgi Network Vesicle Budding","Signaling by TGF-beta Receptor Complex in Cancer","HIV Infection","Phase 3 - rapid re
polarisation","Toll Like Receptor 5 (TLR5) Cascade","Golgi Associated Vesicle Biogenesis","Loss of Function of SMAD2/3 in Cancer","Host Interactions of HIV factors","Toll Like Receptor 4 (TLR4) Cascad
e","MyD88 cascade initiated on plasma membrane","SMAD2/3 Phosphorylation Motif Mutants in Cancer","The role of Nef in HIV-1 replication and disease pathogenesis","MyD88-independent TLR4 cascade","MAP 
kinase activation","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","TRIF(TICAM1)-mediated TLR4 signaling","activated TAK1 mediates p38 MAPK activation"
,"MAPK targets/ Nuclear events mediated by MAP kinases","Nef Mediated CD4 Down-regulation","IKK complex recruitment mediated by RIP1","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{GSK583,1346547-00-9,1346547009,GSK-583,CHEMBL3823499,6-(Tert-Butylsulfonyl)-N-(5-Fluoro-2h-Indazol-3-Yl)quinolin-4-Amine,6(TertButylsulfonyl)N(5Fluoro2hIndazol3Yl)quinolin4Amine,6-tert-butylsulfonyl-
N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine,6tertbutylsulfonylN(5fluoro1Hindazol3yl)quinolin4amine,N-(5-fluoro-1H-indazol-3-yl)-6-(2-methylpropane-2-sulfonyl)quinolin-4-am,N(5fluoro1Hindazol3yl)6(2me
thylpropane2sulfonyl)quinolin4am,T3537}

> <pdid>
PD049179

> <targets>
{NF-?B,RIP1,RIP3}

> <classes>
{Apoptosis}

> <pubchem_cids>
{67469084}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  1  0            999 V2000
    5.1065    0.0000    0.0000 O   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -1.2991    5.2507    0.0000 C   0  0
   -0.0012    6.0029    0.0000 C   0  0
   -0.0036    7.5029    0.0000 C   0  0
    1.2949    8.2554    0.0000 C   0  0
    2.5956    7.5083    0.0000 O   0  0
    1.2921    9.7554    0.0000 C   0  0
    2.5924    9.0081    0.0000 C   0  0
   -1.3039    8.2509    0.0000 C   0  0
   -2.6017    7.4988    0.0000 N   0  0
   -2.5993    5.9988    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
    2.7248    1.2135    0.0000 N   0  0
    3.1904    2.6376    0.0000 C   0  0
    4.6588    2.9478    0.0000 C   0  0  2  0  0  0
    5.6608    1.8315    0.0000 C   0  0
    5.1253    4.3743    0.0000 O   0  0
    6.5929    4.6844    0.0000 C   0  0
    3.1882   -2.6401    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  1  0
 12 15  1  0
 11 16  2  0
 16 17  1  0
 17 18  2  0
 18  9  1  0
  8 19  2  0
 19 20  1  0
 20 21  2  0
 21  6  1  0
 21 22  1  0
 22 23  2  0
 23  4  1  0
  5 24  1  0
 24  2  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  1
 26 28  1  0
 28 29  1  0
  3 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28928

> <plate>
Kinase v5-3

> <well>
F05

> <supplier_cmpd_name>
LY3023414

> <ctcr_id>
11650

> <supplier_cmpd_id>
S8322

> <smiles>
O=c1n(c2c(c3cc(c4cc(C(O)(C)C)cnc4)ccc3nc2)n1C[C@H](C)OC)C

> <pd_targets>
{MTOR,PIK3CB,PIK3CD,PIK3CA,PIK3CG,PIK3R1,PIK3R2,PIK3R3,PIK3R5}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Lipid modifying kinases","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","FRAP subfami
ly"}

> <pathway_reactome>
{"Gene expression (Transcription)","Signal Transduction","Immune System",Disease,Metabolism,"RNA Polymerase II Transcription","Signaling by Receptor Tyrosine Kinases","Cytokine Signaling in Immune sys
tem","Diseases of signal transduction by growth factor receptors and second messengers","Metabolism of lipids","Generic Transcription Pathway","Signaling by Insulin receptor","Signaling by Interleukin
s","Signaling by FGFR in disease","Phospholipid metabolism","Transcriptional Regulation by TP53","Insulin receptor signalling cascade",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Signaling by 
FGFR1 in disease","PI Metabolism","Regulation of TP53 Activity","IRS-mediated signalling","Interleukin receptor SHC signaling","FGFR1 mutant receptor activation","Synthesis of PIPs at the plasma membr
ane","Regulation of TP53 Expression and Degradation","PI3K Cascade","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Degradation"}

> <broad_targets>
{MTOR}

> <broad_moa>
{"mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{Samotolisib,LY3023414,1386874-06-1,1386874061,LY-3023414,GTPL8918,UNII-C88817F47Y,UNIIC88817F47Y,"Samotolisib (USAN)",C88817F47Y,"LY 3023414","example 1 (US8440829)",CHEMBL4297181,SCHEMBL10321700,BCP
16703,EX-A2728,EXA2728,NSC789968,NSC800994,s8322,"WHO 10889",ZINC143116580,CCG-2,CCG2,T6883}

> <pdid>
PD050494

> <targets>
{mTOR,PI3K,DNA-PK,"mTOR kinase","class I PI3K isoforms",Autophagy}

> <classes>
{DNA Damage/DNA Repair,PI3K/Akt/mTOR signaling,Autophagy,Cell Cycle/DNA Damage,PI3K/Akt/mTOR}

> <pubchem_cids>
{57519748}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 23  0  0  0  0            999 V2000
    7.5987   -1.2614    0.0000 H   0  3
    5.0987   -1.2614    0.0000 Cl  0  5
    2.5981   -1.5000    0.0000 I   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8978   -0.7496    0.0000 S   0  0
   -3.8974    0.7504    0.0000 O   0  0
   -2.5987    0.0002    0.0000 O   0  0
   -5.1981   -1.4992    0.0000 N   0  0
   -5.1012   -3.0033    0.0000 C   0  0
   -6.2014   -4.0229    0.0000 C   0  0
   -7.6846   -3.7984    0.0000 C   0  0
   -8.4337   -2.4989    0.0000 N   0  0
   -7.8848   -1.1029    0.0000 C   0  0
   -6.4512   -0.6617    0.0000 C   0  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 13 14  1  0
 14 15  2  0
 14 16  2  0
 14 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 17  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
28929

> <plate>
Kinase v5-3

> <well>
F07

> <supplier_cmpd_name>
ML-7 HCl

> <ctcr_id>
3040

> <supplier_cmpd_id>
S8388

> <smiles>
[H+].[Cl-].Ic1cccc2c1cccc2[S](=O)(=O)N3CCCNCC3

> <pd_targets>
{NPSR1,LMNA,GMNN,CYP3A4,CYP2D6,ROCK1,TP53,CYP2C19,CYP1A2,TSHR,LEF,MYLK,NFKB1,RORC,MTOR,CHRM1,NFO,MAPT,MAPK1,PMP22,KMT2A,MEN1,TRPC6}

> <pathway_gtopdb>
{"Membrane receptor","Other nuclear protein","Unclassified protein",Enzyme,"Transcription factor","Other cytosolic protein","Family A G protein-coupled receptor","Cytochrome P450",Kinase,Protease,"Nuc
lear receptor","Peptide receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 2","Protein Kinase","Cytochrome P450 family 1","Metallo protease","Nuclear hormone receptor subfami
ly 1","Short peptide receptor (family A GPCR)","Cytochrome P450 family 3A","Cytochrome P450 family 2D","AGC protein kinase group","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Glycohormone 
receptor","Metallo protease MAE clan","CAMK protein kinase group","Nuclear hormone receptor subfamily 1 group F","Atypical protein kinase group","Neuropeptide receptor","Cytochrome P450 3A4","Cytochro
me P450 2D6","AGC protein kinase DMPK family","Cytochrome P450 2C19","Cytochrome P450 1A1","Metallo protease M34 family","CAMK protein kinase MLCK family","Nuclear hormone receptor subfamily 1 group F
 member 3","Atypical protein kinase PIKK family","AGC protein kinase ROCK subfamily","Atypical protein kinase FRAP subfamily","Epigenetic regulator","Ion channel",Hydrolase,Reader,"Voltage-gated ion c
hannel","Small molecule receptor (family A GPCR)",Bromodomain,"Transient receptor potential channel","Monoamine receptor","CMGC protein kinase group","Acetylcholine receptor","CMGC protein kinase MAPK
 family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{Receptors,Enzymes,"G protein-coupled receptors","Cytochrome P450","Kinases (EC 2.7.x.x)","Nuclear hormone receptors","Neuropeptide S receptor","CYP3 family","CYP2 family: drug metabolising subset","A
GC: Containing PKA",PKG,"PKC families","CYP1 family","Glycoprotein hormone receptors","CAMK: Calcium/calmodulin-dependent protein kinases","1F. Retinoic acid-related orphans",Atypical,"DMPK family","M
yosin Light Chain Kinase (MLCK) family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Rho kinase","FRAP subfamily","Ion channels","Voltage-gated ion channels","Acetylcholine recepto
rs (muscarinic)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Transient Receptor Potential channels","Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{Disease,"Cell Cycle",Metabolism,"Developmental Biology","Signal Transduction","Immune System","Gene expression (Transcription)","Infectious disease",Mitotic,"Metabolism of lipids","Biological oxidati
ons","Nervous system development","Cell Cycle Checkpoints","Signaling by Rho GTPases","Cytokine Signaling in Immune system","RNA Polymerase II Transcription","Leishmania infection","M Phase","Mitotic 
G1 phase and G1/S transition","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","Axon guidance","G1/S DNA Damage Checkpoints","Uptake and actions o
f bacterial toxins","RHO GTPase Effectors","Signaling by Interleukins","Generic Transcription Pathway","Leishmania parasite growth and survival","Mitotic Metaphase and Anaphase","G1/S Transition","Bio
synthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Semaphorin interactions","p53-Dependent G1/S DNA damage checkpoint","Uptake and function of anthrax toxins","RHO GTPases 
activate PAKs","Interleukin-1 family signaling","Transcriptional regulation by RUNX3","Transcriptional Regulation by TP53","Anti-inflammatory response favouring Leishmania parasite infection","Mitotic
 Anaphase","Activation of the pre-replicative complex","Biosynthesis of maresins",Xenobiotics,"Sema4D in semaphorin signaling","p53-Dependent G1 DNA Damage Response","Interleukin-1 signaling","RUNX3 R
egulates Immune Response and Cell Migration","Regulation of TP53 Activity","ADORA2B mediated anti-inflammatory cytokines production","Nuclear Envelope (NE) Reassembly","Biosynthesis of maresin-like SP
Ms","CYP2E1 reactions","Sema4D induced cell migration and growth-cone collapse","Stabilization of p53","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP3K8 (TPL2)-dependent MAPK1
/3 activation","Regulation of TP53 Expression and Degradation","Initiation of Nuclear Envelope (NE) Reformation","Autodegradation of the E3 ubiquitin ligase COP1","Regulation of TP53 Degradation","Neu
ronal System","Signaling by GPCR","Transmission across Chemical Synapses","Innate Immune System","GPCR ligand binding","Neurotransmitter receptors and postsynaptic signal transmission","Toll-like Rece
ptor Cascades","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Class A/1 (Rhodopsin-like receptors)","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 5 (TLR
5) Cascade","Netrin-1 signaling","Amine ligand-binding receptors","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","Role of second messengers in netrin-1 signaling",
"Muscarinic acetylcholine receptors","Activation of AMPK downstream of NMDARs","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{TRPC6}

> <broad_moa>
{"myosin light chain kinase inhibitor"}

> <synonyms>
{SCHEMBL1981350,110448-33-4,110448334,"ML-7 HYDROCHLORIDE","ML7 HYDROCHLORIDE","1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride","1((5Iodonaphthalen1yl)sulfonyl)1,4diazepane hydrochlor
ide","ML-7 HCl","ML7 HCl","ML 7 hydrochloride","ML 7","ML-7 (hydrochloride)","ML7 (hydrochloride)",1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,1(5Iodonaphthalene1sulfonyl)1Hhexahydro1,"4-diazepine
 hydrochlori","4diazepine hydrochlori",T3050,EI-197,"EMD 475880","ML-7 hydrochloride",475880,ML-7?HCl}

> <pdid>
PD015772

> <targets>
{"Serine/threonin kinase",MLCK,ML-7,Hydrochloride}

> <classes>
{}

> <pubchem_cids>
{67236210,9803932}

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 37  0  0  0  0            999 V2000
    4.6581   -2.9476    0.0000 C   0  0
    3.1905   -2.6376    0.0000 C   0  0
    2.1885   -3.7539    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 N   0  0
    3.1884    2.6409    0.0000 C   0  0
    2.2737    3.8235    0.0000 C   0  0
    2.8432    5.2111    0.0000 C   0  0
    4.3298    5.4118    0.0000 C   0  0
    5.2468    4.2247    0.0000 C   0  0
    4.6773    2.8370    0.0000 C   0  0
    4.9024    6.7990    0.0000 N   0  0
    6.3901    6.9977    0.0000 C   0  0
    7.3050    5.8090    0.0000 O   0  0
    6.9627    8.3849    0.0000 N   0  0
    8.4504    8.5835    0.0000 C   0  0
    9.0248    9.9692    0.0000 C   0  0
   10.5120   10.1647    0.0000 C   0  0
   11.4249    8.9745    0.0000 C   0  0
   10.8506    7.5888    0.0000 C   0  0
    9.3634    7.3933    0.0000 C   0  0
   11.7640    6.3979    0.0000 C   0  0
   13.2513    6.5925    0.0000 F   0  0
   11.1892    5.0124    0.0000 F   0  0
   12.6763    5.2073    0.0000 F   0  0
    8.1119   11.1595    0.0000 F   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000    3.0000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  8  2  3
  8  4  1  0
  7  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  3
 14  9  1  0
 12 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 19 20  2  3
 20 21  1  0
 21 22  2  3
 22 23  1  0
 23 24  2  3
 24 19  1  0
 23 25  1  0
 25 26  1  0
 25 27  1  0
 25 28  1  0
 20 29  1  0
  6 30  1  0
 30 31  2  3
 31 32  1  0
 32 33  2  3
 33  5  1  0
 30 34  1  0
M  END
> <name>
UTKinase_V5

> <id>
28931

> <plate>
Kinase v5-3

> <well>
F11

> <supplier_cmpd_name>
AD80

> <ctcr_id>
12355

> <supplier_cmpd_id>
S8518

> <smiles>
CC(C)N1C2=C(C(=N1)C3=CC=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)C(=NC=N2)N

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{AD80,1384071-99-1,1384071991,AD-80,SCHEMBL14985438,BCP25106,EX-A1372,EXA1372,s8518,ZB1526,ZINC205928292,CCG-269478,CCG269478,CS-6926,CS6926,BS-15325,BS15325,HY-101963,HY101963,AK00783056,T4301}

> <pdid>
PD078303

> <targets>
{c-RET,Src,"S6 Kinase",RET,RAF,SRC,S6K}

> <classes>
{"Tyrosine Kinase/Adaptors",MAPK,Angiogenesis,"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{71578106}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 29  0  0  1  0            999 V2000
   -3.2743    1.4159    0.0000 F   0  0
   -1.8014    1.1320    0.0000 C   0  0
   -1.3109   -0.2856    0.0000 C   0  0
    0.0000   -0.7500    0.0000 C   0  0
    1.3000   -2.2500    0.0000 C   0  0  1  0  0  0
    1.0511   -3.7292    0.0000 C   0  0
    2.6000   -1.5000    0.0000 N   0  0
    3.9000   -2.2500    0.0000 C   0  0
    5.2000   -1.5000    0.0000 N   0  0
    6.5000   -2.2500    0.0000 C   0  0
    7.8000   -1.5000    0.0000 C   0  0
    8.7979   -2.7118    0.0000 C   0  0
    8.0471   -4.0104    0.0000 N   0  0
    6.4990   -3.7500    0.0000 N   0  0
    5.2000   -4.5000    0.0000 C   0  0
    3.9010   -3.7500    0.0000 C   0  0
    7.8000    0.0000    0.0000 C   0  0
    9.0989    0.7502    0.0000 O   0  0
    6.5000    0.7500    0.0000 N   0  0
    5.2000    0.0000    0.0000 C   0  0
    3.9000    0.7500    0.0000 C   0  0  1  0  0  0
    2.6000    0.0000    0.0000 O   0  0
    1.3000    0.7500    0.0000 C   0  0
    0.6538    1.9816    0.0000 C   0  0
   -0.8191    2.2655    0.0000 C   0  0
    3.9000    2.2500    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  6
  5  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 10  1  0
 14 15  1  0
 15 16  2  0
 16  8  1  0
 11 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23  4  2  0
 23 24  1  0
 24 25  2  0
 25  2  1  0
 21 26  1  1
M  END
> <name>
UTKinase_V5

> <id>
28932

> <plate>
Kinase v5-3

> <well>
F13

> <supplier_cmpd_name>
TPX-0005

> <ctcr_id>
12634

> <supplier_cmpd_id>
S8583

> <smiles>
Fc1cc2[C@@H](C)Nc3nc4c(cnn4cc3)C(=O)NC[C@@H](Oc2cc1)C

> <pd_targets>
{NTRK2,ALK,SRC,ROS1,NTRK1,NTRK3,EML4,JAK2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Tyrosine protein kinase Trk family","TKL protein kinase STKR family","Tyrosine protein kinase Src family","Tyrosin
e protein kinase Sev family","Tyrosine protein kinase JakA family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type VII RTKs: Neurotrophin receptor/Trk family","
Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Src family","Type XVII RTKs: ROS receptors","Janus kinase (JakA) family"}

> <pathway_reactome>
{"Signal Transduction","Cell Cycle","Signaling by Receptor Tyrosine Kinases",Mitotic,"Signaling by NTRKs","Mitotic G1 phase and G1/S transition","Signaling by NTRK1 (TRKA)","Signaling by NTRK3 (TRKC)"
,"G1 Phase","Activation of TRKA receptors","Signalling to ERKs","Activated NTRK3 signals through PI3K","Cyclin D associated events in G1","NGF-independant TRKA activation","Signalling to RAS","Prolong
ed ERK activation events","p38MAPK events","ARMS-mediated activation"}

> <broad_targets>
{}

> <broad_moa>
{"receptor tyrosine protein kinase inhibitor"}

> <synonyms>
{PX000,Repotrectinib,TPX-0005,TPX0005,1802220-02-5,1802220025,Ropotrectinib,08O3FQ4UNP,UNII-08O3FQ4UNP,UNII08O3FQ4UNP,TRX-0005,TRX0005,"Repotrectinib (USAN)",Repotrectinib(TPX-005),Repotrectinib(TPX00
5),CHEMBL4298138,SCHEMBL16946804,GTPL10316,"TPX 0005 (WHO-DD)","TPX 0005 (WHODD)",BDBM374727,EX-A2572,EXA2572,"US10246466, Example 93",N,T4071}

> <pdid>
PD063791

> <targets>
{Src,ALK,ROS,"Trk Receptor"}

> <classes>
{Angiogenesis,Tyrosine Kinase/Adaptors,Neuronal Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{135565923}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 37  0  0  0  0            999 V2000
    1.3000    2.2500    0.0000 C   0  0
    1.3000    0.7500    0.0000 S   0  0
    0.0007    0.0004    0.0000 O   0  0
    2.5993    0.0004    0.0000 O   0  0
    1.3000   -0.7500    0.0000 O   0  0
   11.5904    0.3824    0.0000 O   0  0
   12.8907    1.1301    0.0000 C   0  0
   12.8928    2.6309    0.0000 N   0  0
   11.5946    3.3840    0.0000 C   0  0
   11.5946    4.8840    0.0000 C   0  0
   10.2956    5.6340    0.0000 C   0  0
    8.9965    4.8840    0.0000 C   0  0
    8.9965    3.3840    0.0000 C   0  0
   10.2956    2.6340    0.0000 C   0  0
    7.6963    5.6345    0.0000 C   0  0
    8.9090    6.4540    0.0000 C   0  0
    8.4439    7.8801    0.0000 C   0  0
    6.9439    7.8784    0.0000 C   0  0
    6.4819    6.4513    0.0000 C   0  0
    6.3982    4.8813    0.0000 C   0  0
    5.1007    4.1286    0.0000 N   0  0
   14.1889    0.3770    0.0000 C   0  0
   15.4881    1.1270    0.0000 C   0  0
   16.7871    0.3769    0.0000 C   0  0
   16.7870   -1.1231    0.0000 C   0  0
   15.4880   -1.8730    0.0000 N   0  0
   14.1890   -1.1230    0.0000 C   0  0
   12.8908   -1.8761    0.0000 N   0  0
   12.8929   -3.3769    0.0000 C   0  0
   11.5947   -4.1300    0.0000 C   0  0
   11.5947   -5.6301    0.0000 C   0  0
   10.2957   -6.3801    0.0000 C   0  0
    8.9966   -5.6301    0.0000 N   0  0
    8.9965   -4.1301    0.0000 C   0  0
   10.2956   -3.3801    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  2  0
  2  5  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 12 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 15  1  0
 15 20  1  0
 20 21  3  0
  7 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
28933

> <plate>
Kinase v5-3

> <well>
F15

> <supplier_cmpd_name>
Apatinib

> <ctcr_id>
4550

> <supplier_cmpd_id>
S5248

> <smiles>
CS(=O)(=O)O.O=C(Nc1ccc(cc1)C2(CCCC2)C#N)c3cccnc3NCc4ccncc4

> <pd_targets>
{KDR,KIT,RET,CSK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Ret family","Tyrosine protein kinase Cs
k family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type IV RTKs: VEGF (vascular endothelial growth fa
ctor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIV RTKs: RET","Csk family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Developmental Biology","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Nervous system devel
opment","Signaling by VEGF","Signaling by KIT in disease","Axon guidance","Oncogenic MAPK signaling","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","RET signaling","Signaling by RAS mutants",
"VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","Signaling downstream of RAS mutants"}

> <broad_targets>
{CSK,KDR,KIT,RET}

> <broad_moa>
{"RET tyrosine kinase inhibitor"}

> <synonyms>
{Apatinib,"Apatinib Mesylate",1218779-75-9,1218779759,"1218779 75 9","Rivoceranib mesylate",YN968D1,YN-968D1,"YN 968D1",UNII-TK02X14ASJ,UNIITK02X14ASJ,"UNII TK02X14ASJ",TK02X14ASJ,Apatinib?mesylate,"A
litan (TN)","Apatinib (YN968D1)","Apatinib - YN968D1","Apatinib  YN968D1","Apatinib   YN968D1","Rivoceranib mesylate (USAN)",cc-605,cc605,"cc 605",MLS006011286,CHEMB,T5153,T2582,S2221,"Apatinib mesyla
te"}

> <pdid>
PD057121

> <targets>
{VEGFR,c-RET}

> <classes>
{"Protein Tyrosine Kinase"}

> <pubchem_cids>
{45139106}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
    1.3689    6.1679    0.0000 C   0  0
    2.4537    5.1320    0.0000 C   0  0
    3.8933    5.5535    0.0000 C   0  0
    4.9781    4.5176    0.0000 C   0  0
    4.6234    3.0602    0.0000 C   0  0
    3.1884    2.6409    0.0000 C   0  0
    2.0990    3.6745    0.0000 C   0  0
    2.7248    1.2135    0.0000 C   0  0
    3.6065    0.0000    0.0000 C   0  0
    2.7248   -1.2135    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2502    0.0000 C   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4988    0.0000 F   0  0
   -3.9055   -5.2465    0.0000 F   0  0
   -3.9083   -6.7463    0.0000 F   0  0
   -2.6003    1.4977    0.0000 O   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 C   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 C   0  0
   -7.7876   -1.5212    0.0000 O   0  0
   -7.7802   -3.0212    0.0000 C   0  0
   -7.7988    1.4819    0.0000 F   0  0
   -5.2060    2.9909    0.0000 F   0  0
    4.2512    7.0111    0.0000 C   0  0
    3.1681    8.0489    0.0000 O   0  0
    5.6921    7.4308    0.0000 N   0  0
    6.0500    8.8883    0.0000 C   0  0
    7.0642    9.8844    0.0000 C   0  0
    5.6068   10.2390    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12  8  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 20 23  1  0
 14 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 28 31  1  0
 31 32  1  0
 27 33  1  0
 26 34  1  0
  3 35  1  0
 35 36  2  0
 35 37  1  0
 37 38  1  0
 38 39  1  0
 39 40  1  0
 40 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
28935

> <plate>
Kinase v5-3

> <well>
H19

> <supplier_cmpd_name>
BAY 1217389

> <ctcr_id>
11623

> <supplier_cmpd_id>
S8215

> <smiles>
Cc1c(ccc(c1)c1cnc2n1nc(cc2NCCC(F)(F)F)Oc1c(c(c(cc1)OC)F)F)C(=O)NC1CC1

> <pd_targets>
{TTK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase TTK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","TTK family"}

> <pathway_reactome>
{}

> <broad_targets>
{}

> <broad_moa>
{"kinase inhibitor"}

> <synonyms>
{1554458-53-5,1554458535,BAY1217389,"Bay 1217389",BAY-1217389,UNII-M964LB1114,UNIIM964LB1114,M964LB1114,CHEMBL4456085,SCHEMBL15555839,EX-A948,EXA948,BDBM258444,BCP17401,NSC787026,s8215,ZINC221039372,C
CG-265387,CCG265387,CS-6182,CS6182,NSC-787026,HY-12859,HY12859,FT-0700219,FT0700219,"US9512130, 2",J-690208,J690208,1-(6-,1(6,T3434}

> <pdid>
PD057592

> <targets>
{Kinesin,"Serine/threonin kinase",Mps1}

> <classes>
{Cytoskeletal Signaling,Cell Cycle/DNA Damage,Cytoskeleton}

> <pubchem_cids>
{78320750}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 37  0  0  0  0            999 V2000
    3.8926   -3.7566    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    3.8976   -0.7553    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -5.2007    1.4909    0.0000 N   0  0
   -6.4972    0.7364    0.0000 C   0  0
   -6.4920   -0.7636    0.0000 C   0  0
   -5.1903   -1.5091    0.0000 C   0  0
   -5.1821   -3.0099    0.0000 N   0  0
   -3.8787   -3.7540    0.0000 C   0  0
   -3.8704   -5.2548    0.0000 C   0  0
   -5.1668   -6.0094    0.0000 N   0  0
   -5.1616   -7.5094    0.0000 C   0  0
   -3.8599   -8.2548    0.0000 C   0  0
   -2.5635   -7.5003    0.0000 N   0  0
   -2.5687   -6.0003    0.0000 C   0  0
   -1.2700   -5.2481    0.0000 N   0  0
   -1.2726   -3.7481    0.0000 C   0  0
    0.0312   -5.9959    0.0000 S   0  0
    1.3292   -5.2440    0.0000 O   0  0
    1.3314   -6.7438    0.0000 O   0  0
    0.0338   -7.4959    0.0000 C   0  0
   -3.8939   -0.7546    0.0000 N   0  0
   -7.7891   -1.5185    0.0000 C   0  0
   -9.0912   -0.7738    0.0000 F   0  0
   -7.7834   -3.0185    0.0000 F   0  0
   -9.0852   -2.2736    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 25 27  2  0
 25 28  1  0
 14 29  2  0
 29 10  1  0
 13 30  1  0
 30 31  1  0
 30 32  1  0
 30 33  1  0
  8 34  1  0
 34 35  2  0
 35  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
28936

> <plate>
Kinase v5-3

> <well>
H21

> <supplier_cmpd_name>
Defactinib (VS-6063, PF-04554878)

> <ctcr_id>
13568

> <supplier_cmpd_id>
S7654

> <smiles>
CNC(=O)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(=O)(=O)C)n2)C(F)(F)F)cc1

> <pd_targets>
{NTRK1,ADORA2A,LYN,MAP3K9,PTK2B,ABL1,PTK2,ADORA3,AURKA,MARK1,GSK3B,CCNA1,CCNA2,CDK2,FLT1,CLK1}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor",Kinase,"Family A G protein-coupled receptor","Protein Kinase","Small molecule receptor (family A GPCR)","TK protein kinase group","Nucleotide-like receptor (family A GPCR)"
,"TKL protein kinase group","Other protein kinase group","CAMK protein kinase group","CMGC protein kinase group","Tyrosine protein kinase Trk family","Adenosine receptor","Tyrosine protein kinase Src 
family","TKL protein kinase MLK family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Abl family","Other protein kinase AUR family","CAMK protein kinase CAMK1 family","CMGC protein kin
ase GSK family","CMGC protein kinase CDK family","Tyrosine protein kinase VEGFR family","CMGC protein kinase CLK family","TKL protein kinase MLK subfamily","CAMK protein kinase MARK subfamily","CMGC p
rotein kinase CDC2 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","G protein-coupled receptors","Kinases (EC 2.7.x.x)","Receptor kinases","Adenosine receptors","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Conta
ining CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Other protein kinases","CAMK-like (CAMKL) family","Glycogen synthase kinase (GSK) family","CLK family","Receptor 
tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Mixed Lineage Kinase (MLK) family","Aurora kinase (Aur) family","MARK subfamily","GSK subfamily","Type VII RTKs: Neurotrophin receptor
/Trk family","Src family","MLK subfamily","Fak family","Abl family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System","Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Infectious disease","Cytokine Signaling in Immune system","Signaling by GPCR"
,"RNA Polymerase II Transcription","Signaling by NTRKs","Leishmania infection","Signaling by Interleukins","GPCR ligand binding","Generic Transcription Pathway","SARS-CoV Infections","Signaling by VEG
F","Signaling by NTRK1 (TRKA)","Leishmania parasite growth and survival","Interleukin-2 family signaling","Parasite infection","Class A/1 (Rhodopsin-like receptors)","Transcriptional Regulation by TP5
3","SARS-CoV-1 Infection","VEGF ligand-receptor interactions","Signalling to ERKs","Anti-inflammatory response favouring Leishmania parasite infection","Interleukin-2 signaling","Leishmania phagocytos
is","Nucleotide-like (purinergic) receptors","Regulation of TP53 Activity","SARS-CoV-1 Genome Replication and Transcription","VEGF binds to VEGFR leading to receptor dimerization","Prolonged ERK activ
ation events","ADORA2B mediated anti-inflammatory cytokines production","FCGR3A-mediated IL10 synthesis","FCGR3A-mediated phagocytosis","Adenosine P1 receptors","Regulation of TP53 Activity through Ph
osphorylation","Replication of the SARS-CoV-1 genome","ARMS-mediated activation"}

> <broad_targets>
{PTK2}

> <broad_moa>
{"focal adhesion kinase inhibitor"}

> <synonyms>
{Defactinib,1073154-85-4,PF-04554878,VS-6063,UNII-53O87HA2QU,"Defactinib (VS-6063, PF-04554878)","Defactinib free base",1345713-71-4,53O87HA2QU,"1073154-85-4 (free base)","VS 6063",VS6063,"Defactinib 
(USAN:INN)","Defactinib (USAN/INN)",GTPL7910,SCHEMBL1627234,C20H21F3N8O3S,CHEMBL3137331,"Defactinib (PF-04554878)",BDBM418817,HMS3740O13,AMY42170,AOB87723,BCP11299,EX-A1037,EX-A1049,2361AH,MFCD2597780
6,NSC778364,NSC781450,NSC782549,NSC800089,s7654,"US10450297, Example 317","US10450297, Example 318",AKOS026750300,ZINC103297739,CCG-269780,CS-3410,DB12282,NSC-778364,NSC-781450,NSC-782549,NSC-800089,S
B17060,NCGC00386425-06,NCGC00386425-11,AK546976,AS-17045,DA-34914,DA-45890,HY-12289,FT-0706351,FT-0721609,J3.502.756D,"PF 04554878",A11929,D10618,J-690021,Q27077009,7KD,T1996}

> <pdid>
PD012994

> <targets>
{FAK}

> <classes>
{Angiogenesis,Cytoskeletal Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{25117126}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 37  0  0  0  0            999 V2000
    1.2990   -2.9545    0.0000 C   0  0
    2.7822   -3.1780    0.0000 N   0  0
    3.7175   -2.0053    0.0000 C   0  0
    5.2020   -2.2259    0.0000 N   0  0
    6.1361   -1.0512    0.0000 C   0  0
    5.5833    0.3433    0.0000 C   0  0
    6.5145    1.5193    0.0000 C   0  0
    7.9985    1.3008    0.0000 C   0  0
    8.9301    2.4774    0.0000 N   0  0
    8.3795    3.8728    0.0000 C   0  0
    9.3126    5.0473    0.0000 C   0  0
   10.7963    4.8265    0.0000 N   0  0
   11.7293    6.0010    0.0000 C   0  0
   11.3469    3.4312    0.0000 C   0  0
   10.4138    2.2567    0.0000 C   0  0
    8.5513   -0.0936    0.0000 C   0  0
    7.6201   -1.2695    0.0000 C   0  0
    8.1762   -2.6636    0.0000 O   0  0
    9.6605   -2.8798    0.0000 C   0  0
    3.1695   -0.6090    0.0000 N   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 N   0  0
    2.5242    2.0130    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
    0.1115    3.2255    0.0000 C   0  0
   -1.1278    4.0705    0.0000 C   0  0
   -2.4793    3.4196    0.0000 C   0  0
   -2.5914    1.9238    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -3.1476   -0.7184    0.0000 O   0  0
   -0.7500   -1.5574    0.0000 N   0  0
    0.7500   -1.5574    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  1  0
 14 15  1  0
 15  9  1  0
  8 16  1  0
 16 17  2  0
 17  5  1  0
 17 18  1  0
 18 19  1  0
  3 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 29 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  1  0
 33  1  1  0
 33 21  2  0
M  END
> <name>
UTKinase_V5

> <id>
28937

> <plate>
Kinase v5-3

> <well>
H03

> <supplier_cmpd_name>
XMD8-87

> <ctcr_id>
11781

> <supplier_cmpd_id>
S8272

> <smiles>
c1nc(Nc2ccc(N3CCN(C)CC3)cc2OC)nc2n(C)c3ccccc3c(=O)[nH]c12

> <pd_targets>
{TNK2,MAPK7,FRK,PTK6}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","Tyrosine protein kinase Ack family","CMGC protein kinase MAPK family","Tyrosine protein kinase Src family","CMGC 
protein kinase ERK5"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases
)","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","Ack family","Src family"}

> <pathway_reactome>
{"Immune System","Signal Transduction","Cell Cycle","Innate Immune System","Intracellular signaling by second messengers",Mitotic,"Toll-like Receptor Cascades","PIP3 activates AKT signaling","Mitotic 
G1 phase and G1/S transition","Toll Like Receptor 5 (TLR5) Cascade","PTEN Regulation","G1 Phase","MyD88 cascade initiated on plasma membrane","Regulation of PTEN stability and activity","Cyclin D asso
ciated events in G1","MAP kinase activation","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MD88,XMD8-87,XMD887,1234480-46-6,1234480466,ACK1-B19,ACK1B19,CHEMBL1672987,LUN80466,"XMD 8-87","XMD 887","1234480-46-6 (free base)","1234480466 (free base)","Scaffold, B19",SCHEMBL619088,BCP19603,BCP
19604,EX-A1296,EXA1296,BDBM50337126,s8272,ZINC66066132,AKOS030632024,CCG-269185,CCG269185,CS-6438,CS6438,AC-32974,AC32974,BS-14733,BS14733,HY-15811,HY15811,T3709}

> <pdid>
PD064213

> <targets>
{ACK,TNK2}

> <classes>
{Metabolism}

> <pubchem_cids>
{53322923}

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 45  0  0  1  0            999 V2000
    3.8976   -0.7465    0.0000 C   0  0
    2.5998   -1.4987    0.0000 C   0  0  2  0  0  0
    2.6028   -2.9995    0.0000 N   0  0
    3.9036   -3.7481    0.0000 C   0  0
    5.2013   -2.9960    0.0000 O   0  0
    3.9065   -5.2490    0.0000 C   0  0
    2.6931   -6.1089    0.0000 C   0  0
    1.7439   -5.7943    0.0000 N   0  0
    3.1568   -7.5355    0.0000 N   0  0
    4.6560   -7.5351    0.0000 N   0  0
    5.6598   -8.6497    0.0000 C   0  0
    7.1270   -8.3377    0.0000 C   0  0
    7.5904   -6.9111    0.0000 C   0  0
    6.5866   -5.7964    0.0000 N   0  0
    5.1194   -6.1084    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8978    0.7496    0.0000 C   0  0
   -5.1976   -0.0009    0.0000 C   0  0
   -6.4973   -0.7513    0.0000 C   0  0
   -6.6351   -2.2321    0.0000 C   0  0
   -8.1023   -2.5440    0.0000 N   0  0
   -8.8523   -1.2449    0.0000 N   0  0
  -10.3441   -1.0881    0.0000 C   0  0
   -7.8486   -0.1302    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000   -3.0008    0.0000 C   0  0
   -1.2978   -3.7529    0.0000 C   0  0
   -1.2955   -5.2529    0.0000 C   0  0
    0.0048   -6.0009    0.0000 C   0  0
    1.3026   -5.2488    0.0000 C   0  0
    1.3002   -3.7488    0.0000 C   0  0
  2  1  1  6
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  7  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15  6  2  0
 15 10  1  0
  2 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  3  0
 24 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 28 30  1  0
 30 25  2  0
 22 31  2  0
 31 18  1  0
 31 32  1  0
 32 33  2  0
 32 34  1  0
 34 16  1  0
 34 35  1  0
 35 36  2  0
 36 37  1  0
 37 38  2  0
 38 39  1  0
 39 40  2  0
 40 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
28938

> <plate>
Kinase v5-3

> <well>
H05

> <supplier_cmpd_name>
IPI-549

> <ctcr_id>
15512

> <supplier_cmpd_id>
S8330

> <smiles>
C[C@H](NC(=O)c1c(N)nn2cccnc12)C3=Cc4cccc(C#Cc5cnn(C)c5)c4C(=O)N3c6ccccc6

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{IPI-549,HY-100716,Eganelisib,Eganelisib}

> <pdid>
PD057959

> <targets>
{PI3K}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 32  0  0  1  0            999 V2000
    5.1903    1.5091    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0  2  0  0  0
    5.2007   -1.4909    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0  1  0  0  0
    7.7884    1.5180    0.0000 O   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0049   -5.9994    0.0000 C   0  0
    0.0102   -7.4994    0.0000 C   0  0
    1.3118   -8.2449    0.0000 C   0  0
    2.6082   -7.4904    0.0000 C   0  0
    2.6030   -5.9904    0.0000 C   0  0
    1.3014   -5.2449    0.0000 C   0  0
    3.7260   -8.4895    0.0000 N   0  0
    3.1206   -9.8619    0.0000 C   0  0
    1.6283   -9.7103    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  6  7  1  6
  3  8  1  6
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  9  1  0
 18 13  1  0
 16 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 23 26  1  0
 26 27  2  0
 27 28  1  0
 28 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28939

> <plate>
Kinase v5-3

> <well>
H07

> <supplier_cmpd_name>
NCB-0846

> <ctcr_id>
11689

> <supplier_cmpd_id>
S8392

> <smiles>
C1C[C@H](CC[C@H]1O)Oc1cccc2cnc(nc12)Nc1cc2c(cc1)nc[nH]2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{CB084,NCB-0846,NCB0846,1792999-26-8,1792999268,cis-4-(2-(3H-Benzo(d)imidazol-5-ylamino)quinazolin-8-yloxy)cyclohexanol,cis4(2(3HBenzo(d)imidazol5ylamino)quinazolin8yloxy)cyclohexanol,cis-4-((2-(1H-Be
nzimidazol-6-ylamino)-8-quinazolinyl)oxy)-cyclohexanol,cis4((2(1HBenzimidazol6ylamino)8quinazolinyl)oxy)cyclohexanol,Cis-4-((2-(1h-Benzimidazol-5-Ylamino)quinazolin-8-Yl)oxy)cyclohexanol,Cis4((2(1hBen
zimidazol5Ylamino)quinazolin8Yl)oxy)cyclohexanol,SCHEMBL1804,T4011}

> <pdid>
PD063722

> <targets>
{Wnt/beta-catenin,TNIK}

> <classes>
{"Cytoskeletal Signaling","Stem Cells"}

> <pubchem_cids>
{91801204}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 30  0  0  0  0            999 V2000
    7.4223   -2.8043    0.0000 O   0  0
    6.4202   -1.6882    0.0000 C   0  0
    6.8858   -0.2623    0.0000 C   0  0
    5.8837    0.8539    0.0000 C   0  0
    6.3495    2.2805    0.0000 N   0  0
    7.8167    2.5927    0.0000 C   0  0
    8.2800    4.0194    0.0000 C   0  0
    7.2761    5.1339    0.0000 O   0  0
    5.8089    4.8218    0.0000 C   0  0
    5.3456    3.3952    0.0000 C   0  0
    4.4160    0.5441    0.0000 O   0  0
    3.9504   -0.8818    0.0000 C   0  0
    4.9525   -1.9980    0.0000 C   0  0
    4.2013   -3.2954    0.0000 S   0  0
    2.7345   -2.9814    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10  5  1  0
  4 11  1  0
 11 12  1  0
 12 13  2  0
 13  2  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 12  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 20  1  0
 25 26  2  0
 26 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28942

> <plate>
Kinase v5-3

> <well>
H13

> <supplier_cmpd_name>
SF2523

> <ctcr_id>
11630

> <supplier_cmpd_id>
S8589

> <smiles>
O=c1cc(N2CCOCC2)oc2c1scc2c1ccc2OCCOc2c1

> <pd_targets>
{PIK3CA,PIK3CD,PIK3R1,PIM1,PIK3CG,PIK3R2,MTOR,PIK3CB}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","CAMK protein kinase group","Atypical protein kinase group","CAMK protein kinase PIM family","Atypical protein kinase PIKK family","Atypical protein kinase 
FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Glycerophospholipid turnover","Lipid modifying kinases","Phosphatidylinositol kinases","CAMK: Calcium/calmodulin-dependent protein kinases",Atypical,Phosphatidylinosit
ol-4,"5-bisphosphate 3-kinase family","PIM family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","FRAP subfamily"}

> <pathway_reactome>
{Disease,"Immune System",Metabolism,"Signal Transduction","Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Im
mune system","Metabolism of lipids","Signaling by Receptor Tyrosine Kinases","RNA Polymerase II Transcription","Signaling by FGFR in disease","Signaling by Interleukins","FLT3 signaling in disease","P
hospholipid metabolism","Signaling by Insulin receptor","Generic Transcription Pathway","Signaling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Signaling by FLT3 ITD and TK
D mutants","PI Metabolism","Insulin receptor signalling cascade","Transcriptional Regulation by TP53","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","STAT5 activation downstre
am of FLT3 ITD mutants","Synthesis of PIPs at the plasma membrane","IRS-mediated signalling","Regulation of TP53 Activity","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","Regulation of T
P53 Expression and Degradation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SF2523,1174428-47-7,1174428477,SF-2523,CHEMBL2322228,SCHEMBL2850172,"SF2523 pound>>SF 2523",BCP25252,EX-A1381,EXA1381,BDBM50427453,NSC791024,s8589,AKOS032960486,ZINC101661736,CCG-268310,CCG268310,CS-
6474,CS6474,NSC-791024,SB18840,SF2523?,AC-31531,AC31531,BS-14591,BS14591,HY-101146,HY101146,82V,T3986}

> <pdid>
PD060806

> <targets>
{PI3K,DNA-PK,"Epigenetic Reader Domain",mTOR,BRD4,PI3K¦Á,PI3K¦Ã}

> <classes>
{"DNA Damage/DNA Repair",Chromatin/Epigenetic,"PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{44180156}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 25  0  0  1  0            999 V2000
    5.0987   -2.4129    0.0000 O   0  0
    2.5981   -1.5000    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -3.8813   -1.4408    0.0000 C   0  0  2  0  0  0
   -4.8896   -2.5354    0.0000 O   0  0
   -6.2433   -1.8893    0.0000 C   0  0  2  0  0  0
   -7.5587   -2.6066    0.0000 C   0  0
   -7.5962   -4.1069    0.0000 O   0  0
   -8.9138   -4.8255    0.0000 P   0  0
  -10.1939   -4.0436    0.0000 O   0  0
  -10.2311   -5.5430    0.0000 O   0  0
   -8.9513   -6.3250    0.0000 O   0  0
   -6.0471   -0.4022    0.0000 C   0  0  1  0  0  0
   -7.1349    0.6307    0.0000 O   0  0
   -4.5721   -0.1292    0.0000 C   0  0  1  0  0  0
   -3.9177    1.2205    0.0000 O   0  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11  3  1  0
 11  7  2  0
 12  8  1  6
 12 13  1  0
 13 14  1  0
 14 15  1  6
 15 16  1  0
 16 17  1  0
 17 18  1  0
 17 19  1  0
 17 20  2  0
 14 21  1  0
 21 22  1  1
 21 23  1  0
 23 12  1  0
 23 24  1  1
M  END
> <name>
UTKinase_V5

> <id>
28943

> <plate>
Kinase v5-3

> <well>
H15

> <supplier_cmpd_name>
Adenosine 5'-monophosphate monohydrate

> <ctcr_id>
5587

> <supplier_cmpd_id>
S5284

> <smiles>
O.Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]3O

> <pd_targets>
{PKM,PYK,RXFP1,CCK,FBP1,DNPH1,SRC,TRPM2,P2RY1,P2RY11,TRPM4,P2RY2,PRKAA1,PRKAB1,PRKAG1,AK2,ADORA2A,POL,PRKAA2,PRKAB2,PRKAG2,PRKAG3,SMN1,LDHA,ADORA1,CREB1}

> <pathway_gtopdb>
{Enzyme,"Membrane receptor","Secreted protein","Ion channel","Epigenetic regulator","Unclassified protein",Transferase,"Family A G protein-coupled receptor",Hydrolase,Kinase,"Voltage-gated ion channel
",Protease,Reader,Oxidoreductase,"Peptide receptor (family A GPCR)","Protein Kinase","Transient receptor potential channel","Small molecule receptor (family A GPCR)","Aspartic protease","Methyl-lysine
/arginine binding protein","Protein kinase regulatory subunit","Relaxin-like peptide receptor (family A GPCR)","TK protein kinase group","Nucleotide-like receptor (family A GPCR)","Monoamine-derivativ
e receptor (family A GPCR)","CAMK protein kinase group","Aspartic protease AA clan","Tudor domain","Relaxin receptor","Tyrosine protein kinase Src family","Purine receptor","Melatonin receptor","CAMK 
protein kinase CAMK1 family","Adenosine receptor","Aspartic protease A2A subfamily","CAMK protein kinase AMPK subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Ion channels","2.7.1.40 Pyruvate kinases","G protein-coupled receptors","Catalytic receptors","Voltage-gated ion channels","Kinases (EC 2.7.x.x)","Relaxin family peptide receptors"
,"Receptor kinases","Transient Receptor Potential channels","P2Y receptors","Receptor guanylyl cyclase (RGC) family","Adenosine receptors","CAMK: Calcium/calmodulin-dependent protein kinases","TK: Tyr
osine kinase","Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase","CAMK-like (CAMKL) family","Non-receptor tyrosine kinases (nRTKs)","AMPK subfamily","Src family"}

> <pathway_reactome>
{Metabolism,Disease,"Signal Transduction","Transport of small molecules","Metabolism of RNA","Immune System","Gene expression (Transcription)","Metabolism of carbohydrates","Infectious disease","Signa
ling by GPCR","Metabolism of nucleotides","Signaling by Receptor Tyrosine Kinases","Ion channel transport","Metabolism of non-coding RNA","The citric acid (TCA) cycle and respiratory electron transpor
t","Innate Immune System","RNA Polymerase II Transcription","Glucose metabolism","Leishmania infection","GPCR ligand binding","Nucleobase catabolism","Signaling by NTRKs","Stimuli-sensing channels","I
nterconversion of nucleotide di- and triphosphates","snRNP Assembly","Pyruvate metabolism and Citric Acid (TCA) cycle","Toll-like Receptor Cascades","Generic Transcription Pathway",Glycolysis,"Leishma
nia parasite growth and survival","Class A/1 (Rhodopsin-like receptors)",Gluconeogenesis,"Purine catabolism","Signaling by NTRK1 (TRKA)","TRP channels","Pyruvate metabolism","Toll Like Receptor 5 (TLR
5) Cascade","Transcriptional Regulation by TP53","Anti-inflammatory response favouring Leishmania parasite infection","Peptide ligand-binding receptors","Signalling to ERKs","Nucleotide-like (purinerg
ic) receptors","MyD88 cascade initiated on plasma membrane","Regulation of TP53 Activity","ADORA2B mediated anti-inflammatory cytokines production","Signalling to RAS","P2Y receptors","Adenosine P1 re
ceptors","MAP kinase activation","Regulation of TP53 Activity through Phosphorylation","p38MAPK events","MAPK targets/ Nuclear events mediated by MAP kinases","CREB phosphorylation"}

> <broad_targets>
{ACSL1,ACSS1,ACSS2,ADCY1,ADK,CREB1,FBP1,HINT1,PDE4B,PDE4D,PIM1,PRKAA1,PRKAB1,PRKAB2,PYGL,TRPM4}

> <broad_moa>
{"adenosine receptor agonist"}

> <synonyms>
{RESTW35,"RESTW 35","Adenosine 5'-monophosphate monohydrate","Adenosine 5'monophosphate monohydrate","Adenosine 5' monophosphate monohydrate",18422-05-4,18422054,"18422 05 4","5'-Adenylic acid, hydrat
e (1:1)","5'Adenylic acid, hydrate (1:1)",5',Prestw-356}

> <pdid>
PD001648

> <targets>
{AMPK}

> <classes>
{}

> <pubchem_cids>
{6419976}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 32  0  0  0  0            999 V2000
   10.3020    0.0267    0.0000 C   0  0
    8.8020    0.0216    0.0000 C   0  0
    7.9161    1.2320    0.0000 C   0  0
    6.4920    0.7636    0.0000 C   0  0
    6.4972   -0.7364    0.0000 C   0  0
    7.9245   -1.1950    0.0000 O   0  0
    5.2007   -1.4909    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 O   0  0
    0.0042   -5.9990    0.0000 C   0  0
   -3.8994   -3.7478    0.0000 O   0  0
   -5.1973   -2.9959    0.0000 C   0  0
    8.3768    2.6577    0.0000 C   0  0
    7.3710    3.7705    0.0000 O   0  0
    9.8442    2.9730    0.0000 N   0  0
   10.3054    4.4003    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  2  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  4  1  0
  8 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 12  1  0
 21 16  1  0
 19 22  1  0
 22 23  1  0
 18 24  1  0
 24 25  1  0
  3 26  1  0
 26 27  2  0
 26 28  1  0
 28 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28944

> <plate>
Kinase v5-3

> <well>
H17

> <supplier_cmpd_name>
Fruquintinib

> <ctcr_id>
11314

> <supplier_cmpd_id>
S5667

> <smiles>
Cc1c(c2c(o1)cc(cc2)Oc1ncnc2cc(c(cc12)OC)OC)C(=O)NC

> <pd_targets>
{KDR,FLT4,FLT1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","VEGFA-VEGFR2 Pathway","VEGF ligand-receptor interactions","VEGFR2 mediated cell proliferation","VEGF binds to VEGFR
 leading to receptor dimerization"}

> <broad_targets>
{KDR}

> <broad_moa>
{"VEGFR inhibitor"}

> <synonyms>
{Fruquintinib,1194506-26-7,1194506267,HMPL-013,HMPL013,Fruquintinib(HMPL-013),Fruquintinib(HMPL013),UNII-49DXG3M5ZW,UNII49DXG3M5ZW,49DXG3M5ZW,"6-(6,7-dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzof
uran-3-carboxamide","6(6,7dimethoxyquinazolin4yl)oxyN,2dimethyl1benzofuran3carboxamide","6-((6,7-dimethoxyquinazolin-4-yl)oxy)-N,2-dimethylbenzofuran-3-carboxamide","6((6,7dimethoxyquinazolin4yl)oxy)N
,2dimethylbenzofuran3carboxamide",6,T2656}

> <pdid>
PD052672

> <targets>
{VEGFRs,VEGFR}

> <classes>
{Angiogenesis,Tyrosine Kinase/Adaptors,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{44480399}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 38  0  0  0  0            999 V2000
    5.1932   -3.0130    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
   -0.0053   -2.9973    0.0000 N   0  0
   -1.3065   -3.7451    0.0000 C   0  0
   -1.3090   -5.2451    0.0000 O   0  0
   -2.6052   -2.9930    0.0000 C   0  0
   -3.9058   -3.7404    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -5.1968    1.5003    0.0000 C   0  0
   -5.1993    3.0004    0.0000 C   0  0
   -6.4995    3.7483    0.0000 C   0  0
   -7.7974    2.9963    0.0000 C   0  0
   -7.7950    1.4963    0.0000 C   0  0
   -6.4948    0.7483    0.0000 C   0  0
   -6.4924   -0.7517    0.0000 Cl  0  0
   -9.0951    0.7464    0.0000 O   0  0
  -10.3943    1.4962    0.0000 C   0  0
   -6.5050    5.2492    0.0000 O   0  0
   -7.8063    5.9952    0.0000 C   0  0
   -3.9015    3.7525    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  4  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  2  0
  3 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 17  1  0
 22 23  2  0
 23 14  1  0
 19 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 24  1  0
 29 30  1  0
 28 31  1  0
 31 32  1  0
 26 33  1  0
 33 34  1  0
 25 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
28946

> <plate>
Kinase v5-3

> <well>
J21

> <supplier_cmpd_name>
BLU9931

> <ctcr_id>
12546

> <supplier_cmpd_id>
S7819

> <smiles>
Cc1c(c(ccc1)NC(=O)C=C)Nc1ncc2cc(ccc2n1)c1c(c(cc(c1Cl)OC)OC)Cl

> <pd_targets>
{FGFR4,FGFR1,CYP2D6,FGFR3,CYP2C19,CYP2C9,FGFR2,CYP1A2,CSF1R,CYP3A4}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 2","Cytochrome P450 family 1","Cytochrome P450 family 3","TK protein kinase group","Cytochrome P450 family 2D","Cytochrome P45
0 family 2C","Cytochrome P450 family 1A","Cytochrome P450 family 3A","Tyrosine protein kinase FGFR family","Cytochrome P450 2D6","Cytochrome P450 2C19","Cytochrome P450 2C9","Cytochrome P450 1A1","Tyr
osine protein kinase PDGFR family","Cytochrome P450 3A4"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Cytochrome P450","Receptor kinases","CYP2 family: drug metabolising subset","CYP1 family","CYP3 family","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs
)","Type V RTKs: FGF (fibroblast growth factor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,Metabolism,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers",
"Biological oxidations","RNA Polymerase II Transcription","Metabolism of lipids","Signaling by FGFR","Signaling by FGFR in disease","Phase I - Functionalization of compounds","Generic Transcription Pa
thway","Biosynthesis of specialized proresolving mediators (SPMs)","Signaling by FGFR4","Signaling by FGFR1 in disease","Cytochrome P450 - arranged by substrate type","Signaling by FGFR3 in disease","
Signaling by FGFR2 in disease","Transcriptional Regulation by VENTX","Biosynthesis of DHA-derived SPMs","Downstream signaling of activated FGFR4","FGFR1 mutant receptor activation",Xenobiotics,"Signal
ing by FGFR3 point mutants in cancer","FGFR2 mutant receptor activation","Biosynthesis of maresins","FRS-mediated FGFR4 signaling","Signaling by activated point mutants of FGFR1","CYP2E1 reactions","F
GFR3 mutant receptor activation","Activated point mutants of FGFR2","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthesis of maresin-like SPMs","Signaling by activated point
 mutants of FGFR3"}

> <broad_targets>
{FGFR4}

> <broad_moa>
{"FGFR inhibitor"}

> <synonyms>
{BLU9931,1538604-68-0,1538604680,BLU-9931,"BLU 9931",UNII-FQK825B5DX,UNIIFQK825B5DX,FQK825B5DX,CHEMBL4068896,GTPL8862,SCHEMBL15412407,EX-A608,EXA608,AMY16700,BCP15296,BDBM50233461,MFCD28900729,NSC7853
00,s7819,AKOS026750440,ZINC210903069,CCG-269771,CCG269771,CS-4139,CS4139,NSC-785300,SB19004,NCGC00,T2347}

> <pdid>
PD012806

> <targets>
{FGFR,FGFR1,FGFR2,FGFR3,FGFR4}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{72710839}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  0  0            999 V2000
    2.6074   12.9087    0.0000 O   0  0
    2.9485   11.4480    0.0000 C   0  0
    4.3841   11.0131    0.0000 C   0  0
    4.7253    9.5524    0.0000 C   0  0
    3.6309    8.5265    0.0000 N   0  0
    2.1953    8.9615    0.0000 C   0  0
    1.8541   10.4222    0.0000 C   0  0
    3.9699    7.0645    0.0000 C   0  0
    5.4048    6.6274    0.0000 C   0  0
    5.7436    5.1661    0.0000 C   0  0
    4.6476    4.1420    0.0000 C   0  0
    3.2127    4.5792    0.0000 C   0  0
    2.8739    6.0405    0.0000 C   0  0
    4.9837    2.6793    0.0000 N   0  0
    3.8856    1.6562    0.0000 C   0  0
    4.2194    0.1938    0.0000 N   0  0
    3.1198   -0.8265    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 N   0  0
    0.0000    3.2286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -2.4523    2.0983    0.0000 C   0  0
   -3.8856    1.6561    0.0000 C   0  0
   -4.2194    0.1937    0.0000 C   0  0
   -3.1198   -0.8265    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.4008   -2.9088    0.0000 O   0  0
    0.7500   -1.5574    0.0000 N   0  0
    2.4522    2.0983    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 11 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 27 28  1  0
 28 29  2  0
 28 30  1  0
 30 18  1  0
 19 31  2  0
 31 15  1  0
M  END
> <name>
UTKinase_V5

> <id>
28947

> <plate>
Kinase v5-3

> <well>
J03

> <supplier_cmpd_name>
XMD16-5

> <ctcr_id>
11783

> <supplier_cmpd_id>
S8273

> <smiles>
OC1CCN(CC1)c1ccc(cc1)Nc1ncc2c(n(C)c3ccccc3c(=O)[nH]2)n1

> <pd_targets>
{AURKA,AURKB}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Other protein kinase group","Other protein kinase AUR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","Other protein kinases","Aurora kinase (Aur) family"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","RNA Polymerase II Transcription",Mitotic,"Generic Transcription Pathway","M Phase","Transcriptional Regulation by TP53","Mitotic Metaphase and Anaphase
","Regulation of TP53 Activity","Mitotic Anaphase","Regulation of TP53 Activity through Phosphorylation","Separation of Sister Chromatids"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MD16,XMD16-5,XMD165,1345098-78-3,1345098783,SCHEMBL16065780,BDBM86612,BCP19605,EX-A1297,EXA1297,s8273,ZINC87723473,AKOS030632026,CCG-268843,CCG268843,CS-6440,CS6440,AK684353,BS-15213,BS15213,HY-10124
3,HY101243,"Benzo(e)pyrimido(5,4-b)(1,4)diazepin-6(11H)-one, 18","Benzo(e)pyrimido(5,4b)(1,4)diazepin6(11H)one, 18",T3710}

> <pdid>
PD063658

> <targets>
{ACK,TNK2,Tyrosinase}

> <classes>
{Metabolism,Metabolic Enzyme/Protease}

> <pubchem_cids>
{57340666}

$$$$
UTKinase_V5
  SciTegic11012413002D

 28 31  0  0  1  0            999 V2000
    3.1476   -0.7184    0.0000 C   0  0
    1.6852   -0.3846    0.0000 N   0  0
    1.3514    1.0778    0.0000 C   0  0
    2.5242    2.0130    0.0000 O   0  0
    0.0000    1.7286    0.0000 C   0  0  2  0  0  0
   -1.3515    1.0777    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 O   0  0
   -0.7500   -1.5574    0.0000 C   0  0
   -1.5000   -2.8577    0.0000 C   0  0
   -0.7500   -4.1567    0.0000 C   0  0
    0.7500   -4.1567    0.0000 C   0  0
    1.5000   -2.8577    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    0.0030    3.2314    0.0000 N   0  0
    1.3039    3.9799    0.0000 C   0  0
    2.6016    3.2277    0.0000 O   0  0
    1.3069    5.4808    0.0000 C   0  0
    2.5204    6.3406    0.0000 N   0  0
    2.0569    7.7672    0.0000 C   0  0
    2.9350    8.9811    0.0000 C   0  0
    2.3225   10.3513    0.0000 C   0  0
    3.1999   11.5680    0.0000 C   0  0
    2.5850   12.9362    0.0000 C   0  0
    1.0927   13.0877    0.0000 C   0  0
    0.2153   11.8712    0.0000 C   0  0
    0.8302   10.5030    0.0000 C   0  0
    0.5569    7.7672    0.0000 N   0  0
    0.0934    6.3406    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  2  1  0
 13  8  1  0
  5 14  1  6
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 19 27  2  0
 27 28  1  0
 28 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28950

> <plate>
Kinase v5-3

> <well>
J09

> <supplier_cmpd_name>
GSK2982772

> <ctcr_id>
15126

> <supplier_cmpd_id>
S8484

> <smiles>
CN1C(=O)[C@H](COc2ccccc12)NC(=O)c3nc(Cc4ccccc4)n[nH]3

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HY-101760,GSK2982772,GSK2982772}

> <pdid>

> <targets>
{RIP kinase}

> <classes>
{Apoptosis}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    0.9513   -6.4982    0.0000 C   0  0
    1.8372   -5.2877    0.0000 C   0  0
    3.3372   -5.2929    0.0000 N   0  0
    3.8056   -3.8679    0.0000 N   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.3786   -3.8595    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 N   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -5.1954   -3.0153    0.0000 C   0  0
   -5.2033   -1.5153    0.0000 O   0  0
   -6.4915   -3.7721    0.0000 N   0  0
   -7.7954   -3.0289    0.0000 O   0  0
   -9.0907   -3.7853    0.0000 C   0  0
   -2.5981    1.5000    0.0000 Cl  0  0
    5.2295   -3.4020    0.0000 C   0  0
    6.3470   -4.4025    0.0000 C   0  0
    5.5377   -1.9340    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  2  1  0
  5  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 25  1  0
 11 26  1  0
  4 27  1  0
 27 28  1  0
 27 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28951

> <plate>
Kinase v5-3

> <well>
J11

> <supplier_cmpd_name>
GSK2256098

> <ctcr_id>
13570

> <supplier_cmpd_id>
S8523

> <smiles>
Cc1nn(c(c1)Nc1ncc(c(c1)Nc1ccccc1C(=O)NOC)Cl)C(C)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"kinase inhibitor"}

> <synonyms>
{GSK2256098,1224887-10-8,GSK-2256098,GTPL7939,"GSK 2256098",SCHEMBL691518,UNII-R7O0O4110G,EX-A671,R7O0O4110G,AMY16729,BCP18311,NSC800999,s8523,AKOS030627136,ZINC114407258,CCG-268826,CS-6083,NSC-800999
,AC-29885,AK676296,AS-74894,HY-100498,Q27077884,T2281}

> <pdid>
PD048377

> <targets>
{FAK}

> <classes>
{Angiogenesis,"Cytoskeletal Signaling"}

> <pubchem_cids>
{46214930}

$$$$
UTKinase_V5
  SciTegic11012413002D

 24 26  0  0  0  0            999 V2000
    4.2146   -6.5095    0.0000 C   0  0
    3.3372   -5.2929    0.0000 C   0  0
    3.8056   -3.8679    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.3786   -3.8595    0.0000 N   0  0
    1.8372   -5.2877    0.0000 N   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5972   -1.5031    0.0000 O   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 C   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
   -2.5764   -7.5048    0.0000 N   0  3
   -1.2737   -8.2485    0.0000 O   0  0
   -3.8715   -8.2616    0.0000 O   0  5
    0.0000    3.0000    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  2  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13  8  1  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 18 21  1  0
 21 22  2  0
 21 23  1  0
 10 24  1  0
M  CHG  2  21   1  23  -1
M  END
> <name>
UTKinase_V5

> <id>
28952

> <plate>
Kinase v5-3

> <well>
J13

> <supplier_cmpd_name>
Autophinib

> <ctcr_id>
11509

> <supplier_cmpd_id>
S8596

> <smiles>
Cc1cc(n[nH]1)Nc1cc(nc(n1)Oc1ccc(cc1)[N+](=O)[O-])Cl

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Autophinib,1644443-47-9,1644443479,6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine,6chloroN(5methyl1Hpyrazol3yl)2(4nitrophenoxy)pyrimidin4amine,6-Chloro-N-(5-methyl-1H-pyraz
ol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine,6ChloroN(5methyl1Hpyrazol3yl)2(4nitrophenoxy)pyrimidinamine,BCP25844,EX-A1537,EXA1537,s8596,ZB1499,CCG-267994,CCG267994,CS-7665,CS7665,BS-16113,BS16113,HY-10
1920,HY101920,AK007,T4219}

> <pdid>
PD063771

> <targets>
{Autophagy,PI3K,"rapamycin-induced autophagy","starvation-induced autophagy",VPS34}

> <classes>
{Autophagy,PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR}

> <pubchem_cids>
{129626605}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0031    3.0008    0.0000 C   0  0
    1.3039    3.7494    0.0000 C   0  0
    1.3092    5.2494    0.0000 C   0  0
    2.6108    5.9949    0.0000 C   0  0
    3.9072    5.2405    0.0000 N   0  0
    3.9020    3.7405    0.0000 C   0  0
    2.6004    2.9949    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5972   -1.5031    0.0000 C   0  0
   -2.5951   -3.0039    0.0000 C   0  0
   -3.8915   -3.7585    0.0000 C   0  0
   -3.8863   -5.2585    0.0000 C   0  0
   -2.5847   -6.0040    0.0000 N   0  0
   -1.2883   -5.2495    0.0000 C   0  0
   -1.2935   -3.7495    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  3 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 13 21  1  0
 21  1  1  0
M  END
> <name>
UTKinase_V5

> <id>
28953

> <plate>
Kinase v5-3

> <well>
J15

> <supplier_cmpd_name>
SC66

> <ctcr_id>
12609

> <supplier_cmpd_id>
S5313

> <smiles>
C1C/C(=C\c2ccncc2)/C(=O)/C(=C/c2ccncc2)/C1

> <pd_targets>
{HSP90AA1,RORC,DDIT3,XBP1,TPR,TGR,HTT,MAPT,AMPC,MAPK1,FFP}

> <pathway_gtopdb>
{"Other cytosolic protein","Transcription factor","Unclassified protein",Enzyme,"Nuclear receptor",Oxidoreductase,Hydrolase,Kinase,Transferase,"Nuclear hormone receptor subfamily 1","Protein Kinase","
Nuclear hormone receptor subfamily 1 group F","CMGC protein kinase group","Nuclear hormone receptor subfamily 1 group F member 3","CMGC protein kinase MAPK family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{"Other protein targets",Receptors,Enzymes,"Heat shock proteins","Nuclear hormone receptors","Kinases (EC 2.7.x.x)","1F. Retinoic acid-related orphans","CMGC: Containing CDK",MAPK,GSK3,"CLK families",
"Mitogen-activated protein kinases (MAP kinases)","ERK subfamily"}

> <pathway_reactome>
{"Cell Cycle","Gene expression (Transcription)","Metabolism of proteins","Neuronal System","Immune System",Mitotic,"RNA Polymerase II Transcription","Unfolded Protein Response (UPR)","Transmission acr
oss Chemical Synapses","Innate Immune System","Mitotic G2-G2/M phases","Generic Transcription Pathway","ATF6 (ATF6-alpha) activates chaperones","Neurotransmitter receptors and postsynaptic signal tran
smission","Toll-like Receptor Cascades","G2/M Transition","Transcriptional regulation by RUNX3","FOXO-mediated transcription","ATF6 (ATF6-alpha) activates chaperone genes","Transcriptional Regulation 
by MECP2","Activation of NMDA receptors and postsynaptic events","Toll Like Receptor 5 (TLR5) Cascade","Centrosome maturation","RUNX3 Regulates Immune Response and Cell Migration","FOXO-mediated trans
cription of cell death genes","Regulation of MECP2 expression and activity","Post NMDA receptor activation events","MyD88 cascade initiated on plasma membrane","Loss of proteins required for interphas
e microtubule organization from the centrosome","Activation of AMPK downstream of NMDARs","MAP kinase activation","Loss of Nlp from mitotic centrosomes","MAPK targets/ Nuclear events mediated by MAP k
inases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SC66,871361-88-5,871361885,"(2E,6E)-2,6-bis(pyridin-4-ylmethylene)cyclohexanone","(2E,6E)2,6bis(pyridin4ylmethylene)cyclohexanone","SC 66",MLS000729928,"(2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexa
none","(2E,6E)2,6Bis(4pyridinylmethylene)cyclohexanone","(2E,6E)-2,6-bis(pyridin-4-ylmethylidene)cyclohexan-1-one","(2E,6E)2,6bis(pyridin4ylmethylidene)cyclohexan1one",SMR000308205,(2E,6E)-2,6E)2,6-bi
s(4-pyridylmethyle,6bis(4pyridylmethyle,T3132}

> <pdid>
PD016579

> <targets>
{Akt}

> <classes>
{"Cytoskeletal Signaling","PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{6018993}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.7237   -2.1806    0.0000 N   0  0
    1.8384   -3.1843    0.0000 C   0  0
    1.5273   -4.6502    0.0000 C   0  0
    0.1007   -5.1138    0.0000 C   0  0
   -1.0140   -4.1101    0.0000 C   0  0
   -0.7022   -2.6429    0.0000 C   0  0
   -1.8166   -1.6389    0.0000 O   0  0
   -2.4404   -4.5769    0.0000 N   0  0
   -2.7504   -6.0453    0.0000 C   0  0
   -4.1753   -6.5139    0.0000 N   0  0
   -4.4821   -7.9822    0.0000 C   0  0
   -3.3639   -8.9820    0.0000 N   0  0
   -1.9389   -8.5135    0.0000 C   0  0
   -1.6322   -7.0452    0.0000 C   0  0
   -0.8207   -9.5134    0.0000 N   0  0
    2.6422   -5.6538    0.0000 C   0  0
    3.1375   -2.4342    0.0000 C   0  0
    4.5078   -3.0443    0.0000 O   0  0
    2.8256   -0.9670    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  1  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12  7  1  0
 12 13  2  0
 11 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 19 21  1  0
  9 22  1  0
  8 23  1  0
 23 24  2  0
 23 25  1  0
 25  1  1  0
M  END
> <name>
UTKinase_V5

> <id>
28957

> <plate>
Kinase v5-3

> <well>
L03

> <supplier_cmpd_name>
eFT-508 (eFT508)

> <ctcr_id>
13447

> <supplier_cmpd_id>
S8275

> <smiles>
C12(CCCCC1)n1c(c(cc(c1=O)Nc1ncnc(c1)N)C)C(=O)N2

> <pd_targets>
{STK17A,CLK4,MKNK2,MKNK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","CAMK protein kinase group","CMGC protein kinase group","CAMK protein kinase DAPK family","CMGC protein kinase CLK family","CAMK protein kinase MAPKAPK family","CAMK pr
otein kinase MNK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CAMK: Calcium/calmodulin-dependent protein kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Death-associated kinase (DAPK) family","CLK family","MAPK-Activate
d Protein Kinase (MAPKAPK) family","MKN subfamily"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by FGFR","Signaling by FGFR4","Negative regulation of FGFR4 signaling","Spry regulation of FGF signaling"}

> <broad_targets>
{}

> <broad_moa>
{"MAPK-interacting kinase inhibitor"}

> <synonyms>
{eFT508,Tomivosertib,EFT-508,EFT508,1849590-01-7,1849590017,"Tomivosertib free base",UNII-U2H19X4WBV,UNIIU2H19X4WBV,U2H19X4WBV,CHEMBL4073443,"EFT 508","1849590-01-7 (free base)","1849590017 (free base
)","eFT508 HCl","eFT-508 (eFT508)","eFT508 (eFT508)","Tomivosertib (INN)","Tomivosertib (USAN)","eFT508; Tomivosertib",Tomiv,T3468}

> <pdid>
PD057001

> <targets>
{MNK,MNK1,MNK2,PD-1/PD-L1}

> <classes>
{MAPK,Immunology/Inflammation,MAPK/ERK Pathway}

> <pubchem_cids>
{118598754}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 32  0  0  0  0            999 V2000
    5.1932   -3.0130    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    2.5765   -7.5048    0.0000 O   0  0
    1.2731   -8.2489    0.0000 C   0  0
    1.2626   -9.7489    0.0000 C   0  0
   -0.0416  -10.4898    0.0000 C   0  0
   -1.3354   -9.7309    0.0000 C   0  0
   -1.3250   -8.2309    0.0000 C   0  0
   -0.0209   -7.4899    0.0000 C   0  0
    1.2883   -5.2495    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0
    3.8994    3.7478    0.0000 O   0  0
    5.1973    2.9959    0.0000 C   0  0
    1.2990    3.7500    0.0000 C   0  0
    1.2959    5.2508    0.0000 O   0  0
   -0.0042    5.9990    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    7.6980   -2.2452    0.0000 Cl  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  4 12  2  0
 12 13  1  0
 13 14  2  0
 14  2  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 19 22  1  0
 22 23  1  0
 23 24  1  0
 22 25  2  0
 25 26  1  0
 26 17  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
28958

> <plate>
Kinase v5-3

> <well>
L05

> <supplier_cmpd_name>
APS-2-79 HCl

> <ctcr_id>
12365

> <supplier_cmpd_id>
S8355

> <smiles>
Cc1cc(Oc2ccccc2)ccc1Nc1c2cc(OC)c(OC)cc2ncn1.Cl

> <pd_targets>
{KSR2}

> <pathway_gtopdb>
{Enzyme,Transferase}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TKL: Tyrosine kinase-like","RAF family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","Oncogenic MAPK signaling","Signaling by RAS mutants","Signaling downstream of RAS mutants"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{PS27,2002381-31-7,2002381317,"APS-2-79 hydrochloride","APS279 hydrochloride","APS-2-79 HCl","APS279 HCl","APS-2-79 (hydrochloride)","APS279 (hydrochloride)","6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl
)quinazolin-4-amine hydrochloride","6,7dimethoxyN(2methyl4phenoxyphenyl)quinazolin4amine hydrochloride",SCHEMBL18153640,BCP23567,EX-A2469,EXA2469,s8355,CCG-268926,CCG268926,CS-6151,CS6151,HY-1006,HY10
06,T6760,APS-2-79}

> <pdid>
PD063742

> <targets>
{MEK,KSR2}

> <classes>
{MAPK,MAPK/ERK Pathway}

> <pubchem_cids>
{122177134}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 35  0  0  0  0            999 V2000
    5.2311   -3.4009    0.0000 O   0  0
    3.8056   -3.8679    0.0000 C   0  0
    2.5951   -3.0039    0.0000 N   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.5532    4.4223    0.0000 O   0  0
   -0.3115    2.9665    0.0000 C   0  0
    0.6890    4.0818    0.0000 C   0  0
    0.2234    5.5086    0.0000 C   0  0
    1.1079    6.7043    0.0000 C   0  0
    0.2222    7.9149    0.0000 C   0  0
    0.6775    9.3423    0.0000 C   0  0
   -0.3320   10.4528    0.0000 N   0  0
    0.1218   11.8826    0.0000 C   0  0
   -0.8895   12.9904    0.0000 C   0  0
   -2.3546   12.6686    0.0000 O   0  0
   -2.8084   11.2389    0.0000 C   0  0
   -1.7972   10.1311    0.0000 C   0  0
   -1.2028    7.4466    0.0000 C   0  0
   -1.1979    5.9466    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.3786   -3.8595    0.0000 C   0  0
   -0.0436   -3.3826    0.0000 O   0  0
    1.8372   -5.2877    0.0000 C   0  0
    3.3372   -5.2929    0.0000 S   0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12  7  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 18  1  0
 16 24  2  0
 24 25  1  0
 25 14  1  0
  8 26  1  0
 26 27  2  0
 27  5  1  0
  3 28  1  0
 28 29  2  0
 28 30  1  0
 30 31  1  0
 31  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
28959

> <plate>
Kinase v5-3

> <well>
L07

> <supplier_cmpd_name>
S49076

> <ctcr_id>
12543

> <supplier_cmpd_id>
S8404

> <smiles>
O=C1N(Cc2cc3c(NC(=O)/C/3=C\c3cc(CN4CCOCC4)c[nH]3)cc2)C(=O)CS1

> <pd_targets>
{AXL}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Axl family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by Receptor Tyrosine Kinases","Signaling by VEGF","VEGFA-VEGFR2 Pathway"}

> <broad_targets>
{}

> <broad_moa>
{"tyrosine kinase inhibitor"}

> <synonyms>
{s49076,1265965-22-7,1265965227,S-49076,S49076,UNII-65ZUU7MATU,UNII65ZUU7MATU,65ZUU7MATU,CHEMBL3808948,"S-49076(Free base)","S49076(Free base)",SCHEMBL259822,EX-A1858,EXA1858,BDBM50172080,s8404,ZINC11
3422876,CCG-269111,CCG269111,CS-6191,CS6191,AC-33035,AC33035,BS-14862,BS14862,HY-12965,HY12965,"S 49076",T3274}

> <pdid>
PD056773

> <targets>
{c-Met,FGFR,"TAM Receptor",Met,FGFR2,FGFR3,AXL,Mer,c-Met/HGFR}

> <classes>
{Angiogenesis,Tyrosine Kinase/Adaptors,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{49870909}

$$$$
UTKinase_V5
  SciTegic11012413002D

 43 47  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 N   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8994    0.7522    0.0000 O   0  0
   -5.1981    1.5045    0.0000 C   0  0
   -5.1930    3.0046    0.0000 C   0  0
   -6.4894    3.7590    0.0000 C   0  0
   -7.7910    3.0135    0.0000 C   0  0
   -9.0897    3.7657    0.0000 N   0  0
  -10.3910    3.0180    0.0000 C   0  0
  -10.3936    1.5180    0.0000 O   0  0
  -11.6897    3.7702    0.0000 C   0  0
  -11.6847    5.2702    0.0000 C   0  0
  -12.9811    6.0247    0.0000 N   0  0
  -12.9729    7.5255    0.0000 C   0  0
  -11.6702    8.2692    0.0000 C   0  0
  -14.2681    8.2822    0.0000 C   0  0
  -14.2827    5.2791    0.0000 C   0  0
  -15.5792    6.0336    0.0000 O   0  0
  -14.2878    3.7791    0.0000 N   0  0
  -15.5901    3.0332    0.0000 C   0  0
  -16.8879    3.7855    0.0000 C   0  0
  -18.1883    3.0379    0.0000 C   0  0
  -18.1910    1.5379    0.0000 C   0  0
  -19.4914    0.7903    0.0000 F   0  0
  -16.8934    0.7855    0.0000 C   0  0
  -15.5929    1.5332    0.0000 C   0  0
  -12.9914    3.0247    0.0000 C   0  0
  -12.9966    1.5247    0.0000 O   0  0
   -7.7962    1.5135    0.0000 C   0  0
   -6.4998    0.7590    0.0000 C   0  0
   -6.5050   -0.7409    0.0000 F   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 O   0  0
   -1.3032   -3.7490    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 21 23  1  0
 20 24  1  0
 24 25  2  0
 24 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 30 32  1  0
 32 33  2  0
 33 27  1  0
 26 34  1  0
 34 18  1  0
 34 35  2  0
 14 36  1  0
 36 37  2  0
 37 11  1  0
 37 38  1  0
  9 39  2  0
 39  5  1  0
 39 40  1  0
 40 41  2  0
 41  3  1  0
 41 42  1  0
 42 43  1  0
M  END
> <name>
UTKinase_V5

> <id>
28961

> <plate>
Kinase v5-3

> <well>
L11

> <supplier_cmpd_name>
RXDX-106 (CEP-40783)

> <ctcr_id>
12814

> <supplier_cmpd_id>
S8570

> <smiles>
COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC

> <pd_targets>
{MET}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Met family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Semaphorin interactions","Sema4D in semaphorin signaling","Sema4D mediated inhibition of cell attachment and migration"}

> <broad_targets>
{}

> <broad_moa>
{"AXL kinase inhibitor"}

> <synonyms>
{EP4078,CEP-40783,CEP40783,1437321-24-8,1437321248,RXDX-106,RXDX106,UNII-1969ZJE05Q,UNII1969ZJE05Q,1969ZJE05Q,"RXDX-106 (CEP-40783)","RXDX106 (CEP40783)",SCHEMBL16089863,BCP25839,EX-A2540,EXA2540,MFCD
28502441,NSC797770,s8570,AKOS032960472,ZINC205893112,CCG-270157,CCG270157,CS-6371,CS6371,NSC-797770,SB18930,AC-31425,AC31425,AS-35141,AS35141,HY-1009,HY1009,T4426}

> <pdid>
PD078301

> <targets>
{"TAM Receptor",AXL,Mer,Tyro3,c-Met/HGFR}

> <classes>
{Tyrosine Kinase/Adaptors,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{71576419}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 42  0  0  0  0            999 V2000
    3.9266   -5.8778    0.0000 C   0  0
    4.8090   -4.6648    0.0000 C   0  0
    6.3007   -4.8230    0.0000 C   0  0
    5.4181   -6.0356    0.0000 C   0  0
    4.2013   -3.2954    0.0000 C   0  0
    2.7345   -2.9814    0.0000 N   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5973    1.5031    0.0000 N   0  0
   -2.5951    3.0039    0.0000 C   0  0
   -1.2948    3.7516    0.0000 O   0  0
   -3.8933    3.7570    0.0000 N   0  0
   -3.8912    5.2578    0.0000 C   0  0
   -5.1876    6.0124    0.0000 C   0  0
   -5.1824    7.5124    0.0000 C   0  0
   -3.8808    8.2579    0.0000 C   0  0
   -2.5844    7.5034    0.0000 C   0  0
   -2.5896    6.0034    0.0000 C   0  0
   -1.2820    8.2493    0.0000 C   0  0
   -1.2759    9.7493    0.0000 F   0  0
    0.0142    7.4944    0.0000 F   0  0
    0.0199    8.9942    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.9504   -0.8818    0.0000 C   0  0
    4.4160    0.5441    0.0000 C   0  0
    3.4139    1.6603    0.0000 N   0  0
    5.8837    0.8539    0.0000 N   0  0
    6.8858   -0.2623    0.0000 C   0  0
    6.4202   -1.6882    0.0000 C   0  0
    4.9525   -1.9980    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 20 22  1  0
 22 23  1  0
 22 24  1  0
 22 25  1  0
 11 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31  8  1  0
 31 26  1  0
  7 32  2  0
 32 33  1  0
 33 34  1  0
 33 35  2  0
 35 36  1  0
 36 37  2  0
 37 38  1  0
 38  5  1  0
 38 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
28962

> <plate>
Kinase v5-3

> <well>
L13

> <supplier_cmpd_name>
kira6

> <ctcr_id>
14886

> <supplier_cmpd_id>
S8658

> <smiles>
CC(C)(C)c1nc(c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c4ccccc24)c5c(N)nccn15

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HY-19708,KIRA6,KIRA6}

> <pdid>
PD017004

> <targets>
{Others,IRE1}

> <classes>
{Cell Cycle/DNA Damage}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 20  0  0  0  0            999 V2000
    7.7985   -2.9932    0.0000 C   0  0
    7.7985   -1.4932    0.0000 C   0  0
    6.4994   -0.7432    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    6.4995   -3.7432    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
    0.0000    3.0000    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  1  1  0
  4  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 13  1  0
 11 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
28963

> <plate>
Kinase v5-3

> <well>
L15

> <supplier_cmpd_name>
NU2058

> <ctcr_id>
11617

> <supplier_cmpd_id>
S5316

> <smiles>
C1CCC(CC1)COc1nc(nc2c1[nH]cn2)N

> <pd_targets>
{CDK5,CCNB1,CDK1,CCNA1,CCNA2,CDK2,CCNB2,CCNB3,AMPC,DYRK1A,MAPK3,MAP3K5,CLK1}

> <pathway_gtopdb>
{Enzyme,Kinase,Hydrolase,"Protein Kinase","CMGC protein kinase group","STE protein kinase group","CMGC protein kinase CDK family","CMGC protein kinase DYRK family","CMGC protein kinase MAPK family","S
TE protein kinase STE11 family","CMGC protein kinase CLK family","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDC2 subfamily","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase ER
K1"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","CMGC: Containing CDK",MAPK,GSK3,"CLK families","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Cyclin-dependent kinase (CDK) family","Dual-specif
icity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Mitogen-activated protein kinases (MAP kinases)","STE11 family","CLK family","CDK5 subfamily","CDK1 subfamily","Dyrk1 subfamily","ER
K subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)","Cell Cycle","Immune System","Cellular responses to external stimuli","RNA Polymerase II Transcription",Mitotic,"Innate Immune System","Cellular responses to stress"
,"Generic Transcription Pathway","Mitotic G1 phase and G1/S transition","Regulation of mitotic cell cycle","Toll-like Receptor Cascades","Cellular Senescence","Transcriptional Regulation by TP53","G0 
and Early G1","APC/C-mediated degradation of cell cycle proteins","Toll Like Receptor 5 (TLR5) Cascade","Oxidative Stress Induced Senescence","Regulation of TP53 Activity","Activation of APC/C and APC
/C:Cdc20 mediated degradation of mitotic proteins","MyD88 cascade initiated on plasma membrane","Regulation of TP53 Activity through Phosphorylation","Regulation of TP53 Expression and Degradation","A
PC/C:Cdc20 mediated degradation of mitotic proteins","MAP kinase activation","Regulation of TP53 Degradation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cy
cle checkpoint","MAPK targets/ Nuclear events mediated by MAP kinases","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{CCNA2,CDK2}

> <broad_moa>
{"cyclin D inhibitor"}

> <synonyms>
{nu2058,161058-83-9,161058839,"6-O-CYCLOHEXYLMETHYL GUANINE","6OCYCLOHEXYLMETHYL GUANINE",6-(cyclohexylmethoxy)-9H-purin-2-amine,6(cyclohexylmethoxy)9Hpurin2amine,2-amino-6-((cyclohexylmethyl)oxy)puri
ne,2amino6((cyclohexylmethyl)oxy)purine,NU-2058,NU2058,"NU 2058","9H-Purin-2-amine, 6-(cyclohexylmethoxy)-","9HPurin2amine, 6(cyclohexylmethoxy)",O6-Cyclohexylmethylguanine,O6Cyclohexylmethylguanine,C
HEMBL269881,MFCD05664734,2-ami,2ami,T3186}

> <pdid>
PD008359

> <targets>
{CDK1,CDK2,"Topo II"}

> <classes>
{"Cell Cycle/Checkpoint","DNA Damage/DNA Repair"}

> <pubchem_cids>
{4564}

$$$$
UTKinase_V5
  SciTegic11012413002D

 31 33  0  0  0  0            999 V2000
    9.9949    2.8884    0.0000 C   0  0
    9.3803    1.5201    0.0000 C   0  0
    7.8873    1.3671    0.0000 S   0  0
    7.0092    2.5832    0.0000 O   0  0
    8.5012    2.7357    0.0000 O   0  0
    7.2749    0.0036    0.0000 N   0  0
    5.8727   -0.5294    0.0000 C   0  0
    6.4440   -1.8462    0.0000 C   0  0
    7.3224   -3.0632    0.0000 C   0  0
    8.8156   -2.9119    0.0000 C   0  0
   10.3080   -2.7606    0.0000 N   0  0
    7.8079   -1.3985    0.0000 C   0  0
    4.9531   -1.9978    0.0000 N   0  0
    3.9511   -0.8815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.7343   -2.9815    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   12.8095   -0.9528    0.0000 O   0  0
   14.1088   -0.2033    0.0000 P   0  0
   15.4080   -0.9528    0.0000 O   0  0
   14.1088    1.2967    0.0000 O   0  0
   14.1088   -1.7033    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  2  0
  3  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  3  0
  8 12  1  0
 12  6  1  0
  8 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 13  1  0
 15 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 18  1  0
 26 22  2  0
 27 28  1  0
 28 29  2  0
 28 30  1  0
 28 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
28964

> <plate>
Kinase v5-3

> <well>
L17

> <supplier_cmpd_name>
Baricitinib phosphate

> <ctcr_id>
202

> <supplier_cmpd_id>
S5754

> <smiles>
CCS(=O)(=O)N1CC(CC#N)(C1)n2cc(cn2)c3ncnc4[nH]ccc34.OP(=O)(O)O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{NCB424ANALOGU,"Baricitinib phosphate",1187595-84-1,1187595841,"Baricitinib (phosphate)","Baricitinib phosphate salt","1187595-84-1 (phosphate)","1187595841 (phosphate)",UNII-XIB47S8NNB,UNIIXIB47S8NNB
,XIB47S8NNB,INCB-28050,INCB28050,SCHEMBL871037,DTXSID30657980,SYN1117,C16H17N7O2S.H3PO4,BCP15527,HY-1531,HY1531,T2360,SY-INCB424-Analogue,Baricitinib Phosphate,INCB424-Analogue}

> <pdid>

> <targets>
{JAK,JAK2,JAK1}

> <classes>
{}

> <pubchem_cids>
{44231848}

$$$$
UTKinase_V5
  SciTegic11012413002D

 23 25  0  0  0  0            999 V2000
    2.6531  -10.0886    0.0000 C   0  0
    1.1844   -9.7837    0.0000 O   0  0
    0.7130   -8.3588    0.0000 C   0  0
   -0.7552   -8.0517    0.0000 C   0  0
   -1.2234   -6.6267    0.0000 C   0  0
   -2.6931   -6.3225    0.0000 O   0  0
   -3.6915   -7.4420    0.0000 C   0  0
   -0.2234   -5.5086    0.0000 C   0  0
   -0.6890   -4.0818    0.0000 C   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.3032   -3.9893    0.0000 O   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.2449   -5.8157    0.0000 C   0  0
    2.2478   -4.6992    0.0000 O   0  0
    3.7156   -5.0084    0.0000 C   0  0
    1.7131   -7.2408    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  5  8  2  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 10  1  0
 19 14  1  0
  8 20  1  0
 20 21  1  0
 21 22  1  0
 20 23  2  0
 23  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
28965

> <plate>
Kinase v5-3

> <well>
N19

> <supplier_cmpd_name>
IC261

> <ctcr_id>
4966

> <supplier_cmpd_id>
S8237

> <smiles>
COc1cc(OC)c(C=C2C(=O)Nc3ccccc23)c(OC)c1

> <pd_targets>
{LMNA,PMP22,THPO,CSNK1D,FTL,CYP2C19,NFO,LEF,BLM,HPGD,HIF1A,ALDH1A1,CYP2C9,CSNK1E,CHRM1,CYP3A4,CSNK1A1,MAPT,TP53,GMNN,CYP1A2,MAPK1}

> <pathway_gtopdb>
{"Other nuclear protein","Unclassified protein",Enzyme,"Transcription factor","Membrane receptor","Other cytosolic protein",Kinase,"Cytochrome P450",Hydrolase,Protease,Oxidoreductase,"Family A G prote
in-coupled receptor","Protein Kinase","Cytochrome P450 family 2","Metallo protease","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Cytochrome P450 family 1","CK1 protein kinase 
group","Cytochrome P450 family 2C","Metallo protease MAE clan","Monoamine receptor","Cytochrome P450 family 3A","Cytochrome P450 family 1A","CMGC protein kinase group","CK1 protein kinase CK1 family",
"Cytochrome P450 2C19","Metallo protease M34 family","Cytochrome P450 2C9","Acetylcholine receptor","Cytochrome P450 3A4","Cytochrome P450 1A1","CMGC protein kinase MAPK family","CMGC protein kinase E
RK1"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Cytochrome P450","Eicosanoid turnover","G protein-coupled receptors","CK1: Casein kinase 1","CYP2 family: drug metabolising subset","Prostaglandin synthases"
,"Acetylcholine receptors (muscarinic)","CYP3 family","CYP1 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Casein kinase 1 (CK1) family","Mitogen-activated protein kinases (MAP kinases)","ER
K subfamily"}

> <pathway_reactome>
{"Cell Cycle","Developmental Biology",Hemostasis,"Vesicle-mediated transport",Metabolism,Disease,"DNA Repair","Cellular responses to external stimuli","Signal Transduction","Neuronal System","Immune S
ystem",Mitotic,"Nervous system development","Platelet activation","signaling and aggregation","Membrane Trafficking","Biological oxidations","Infectious disease","DNA Double-Strand Break Repair","Meta
bolism of lipids","Cellular responses to stress","Signaling by GPCR","Diseases of signal transduction by growth factor receptors and second messengers","Transmission across Chemical Synapses","Cell Cy
cle Checkpoints","Innate Immune System","M Phase","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Platelet Aggregation (Plug Formation)","Mitotic G2-G2/M phases","trans-Golgi Network
 Vesicle Budding","Phase I - Functionalization of compounds","Uptake and actions of bacterial toxins","Homology Directed Repair","Biosynthesis of specialized proresolving mediators (SPMs)","Cellular r
esponse to hypoxia","GPCR ligand binding","Signaling by WNT in cancer","Neurotransmitter receptors and postsynaptic signal transmission","G1/S DNA Damage Checkpoints","Mitotic G1 phase and G1/S transi
tion","Toll-like Receptor Cascades","Mitotic Metaphase and Anaphase","G2/M Transition","Golgi Associated Vesicle Biogenesis","Cytochrome P450 - arranged by substrate type","Uptake and function of anth
rax toxins","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Biosynthesis of DHA-derived SPMs","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha",
"Ethanol oxidation","Class A/1 (Rhodopsin-like receptors)","Signaling by AMER1 mutants","Activation of NMDA receptors and postsynaptic events","p53-Dependent G1/S DNA damage checkpoint","G1/S Transiti
on","Toll Like Receptor 5 (TLR5) Cascade","Mitotic Anaphase","Centrosome maturation",Xenobiotics,"HDR through Homologous Recombination (HRR)","Biosynthesis of D-series resolvins","Amine ligand-binding
 receptors","Biosynthesis of maresins","Truncations of AMER1 destabilize the destruction complex","Post NMDA receptor activation events","p53-Dependent G1 DNA Damage Response","Activation of the pre-r
eplicative complex","MyD88 cascade initiated on plasma membrane","Nuclear Envelope (NE) Reassembly","Loss of proteins required for interphase microtubule organization from the centrosome","CYP2E1 reac
tions","Homologous DNA Pairing and Strand Exchange","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","Activation of AMPK downstream of NMDARs","Stabilization of p53","Aromatic 
amines can be N-hydroxylated or N-dealkylated by CYP1A2","MAP kinase activation","Initiation of Nuclear Envelope (NE) Reformation","Loss of Nlp from mitotic centrosomes","Presynaptic phase of homologo
us DNA pairing and strand exchange","Autodegradation of the E3 ubiquitin ligase COP1","MAPK targets/ Nuclear events mediated by MAP kinases","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{CSNK1A1,CSNK1D,CSNK1E,CSNK1G2}

> <broad_moa>
{"casein kinase inhibitor"}

> <synonyms>
{8661152,186611-52-9,186611529,"3-((2,4,6-trimethoxyphenyl)methylidene)-1H-indol-2-one","3((2,4,6trimethoxyphenyl)methylidene)1Hindol2one",IC-261,IC261,SU5607,"(E)-3-(2,4,6-trimethoxybenzylidene)indol
in-2-one","(E)3(2,4,6trimethoxybenzylidene)indolin2one","1,3-Dihydro-3-((2,4,6-trimethoxyphenyl)methylene)-2H-indol-2-one","1,3Dihydro3((2,4,6trimethoxyphenyl)methylene)2Hindol2one",Maybridge3_000754,
Maybridge3000754,Maybridge3-000754,"Maybridge3 000754",CHEMBL576349,GTPL5985,3,T2440,"EMD 400090",400090}

> <pdid>
PD002683

> <targets>
{"Casein Kinase"}

> <classes>
{}

> <pubchem_cids>
{3674}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 22  0  0  1  0            999 V2000
    7.7996   -1.4883    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0  1  0  0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 O   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -2.5981    3.0000    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    6.4964    0.7591    0.0000 C   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  1  0
  5  6  1  1
  5  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 18 11  1  0
 18 19  1  0
 19  7  1  0
 19 20  2  0
  2 21  1  0
M  END
> <name>
UTKinase_V5

> <id>
28966

> <plate>
Kinase v5-3

> <well>
N03

> <supplier_cmpd_name>
Shikonin

> <ctcr_id>
16174

> <supplier_cmpd_id>
S8279

> <smiles>
CC(=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"C.I. 75535","Isoarnebin 4",HY-N0822,Shikonin,Shikonin}

> <pdid>
PD018927

> <targets>
{"Chloride Channel",Anti-infection,HIV,NF-ºB,"Pyruvate Kinase","TNF Receptor"}

> <classes>
{Anti-infection,Apoptosis,Membrane Transporter/Ion Channel,Metabolic Enzyme/Protease,NF-ºB}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    3.1377    1.5840    0.0000 O   0  0
    4.2567    0.5852    0.0000 C   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    4.2010   -3.2956    0.0000 N   0  0
    2.7343   -2.9815    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 N   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -6.5002    3.7446    0.0000 C   0  0
   -6.6428    5.2250    0.0000 N   0  0
   -8.1110    5.5322    0.0000 N   0  0
   -8.8568    4.2308    0.0000 C   0  0
  -10.3464    4.0695    0.0000 C   0  0
  -11.2327    5.2796    0.0000 F   0  0
  -10.9517    2.6970    0.0000 F   0  0
  -11.8376    3.9072    0.0000 F   0  0
   -7.8496    3.1193    0.0000 O   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.6819    1.0557    0.0000 N   0  0
    5.9880    2.5249    0.0000 C   0  0
    7.4124    2.9951    0.0000 C   0  0
    6.2932    3.9936    0.0000 C   0  0
    4.8689    3.5238    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  3  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 20 22  1  0
 20 23  1  0
 19 24  1  0
 24 16  1  0
 15 25  1  0
 25 26  2  0
 26 12  1  0
 11 27  1  0
 27 28  1  0
 28  8  1  0
  2 29  1  0
 29 30  1  0
 30 31  1  0
 30 32  1  0
 30 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
28967

> <plate>
Kinase v5-3

> <well>
N05

> <supplier_cmpd_name>
WNK463

> <ctcr_id>
12649

> <supplier_cmpd_id>
S8358

> <smiles>
O=C(c1cncn1C1CCN(c2ncc(c3nnc(C(F)(F)F)o3)cc2)CC1)NC(C)(C)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{WNK463,2012607-27-9,2012607279,WNK-463,SCHEMBL20558708,BCP29014,EX-A2547,EXA2547,s8358,ZINC575623808,CCG-269378,CCG269378,CS-5921,CS5921,AK685668,AS-55874,AS55874,HY-100626,HY100626,J3.591.084K,Q2745
5714,CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cn1)-c1nnc(o1)C(F)(F)F,CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cn1)c1nnc(o1)C(F)(F)F,"NVP-WNK463; NVP-WNK 463; NVP-WNK-463","NVPWNK463; NVPWNK 463; NVPWNK463",T7
017}

> <pdid>
PD064971

> <targets>
{"Serine/threonin kinase",WNK,"Ser/Thr Protease"}

> <classes>
{Others,Metabolic Enzyme/Protease}

> <pubchem_cids>
{121487936}

$$$$
UTKinase_V5
  SciTegic11012413002D

 19 19  0  0  1  0            999 V2000
    6.4833   -9.7648    0.0000 C   0  0
    6.4855   -8.2648    0.0000 C   0  0
    5.1873   -7.5117    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    3.8912   -5.2578    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0  1  0  0  0
    5.1937   -3.0093    0.0000 C   0  0
    5.2181   -4.5224    0.0000 C   0  0
    6.5178   -3.7736    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
    7.7858   -7.5171    0.0000 C   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  1
  6  8  1  0
  8  9  2  0
  6 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  3
 15 16  1  0
 16 17  2  3
 17 12  1  0
 15 18  1  0
  2 19  1  0
M  END
> <name>
UTKinase_V5

> <id>
28971

> <plate>
Kinase v5-3

> <well>
N13

> <supplier_cmpd_name>
Bakuchiol

> <ctcr_id>
13791

> <supplier_cmpd_id>
S3813

> <smiles>
CC(=CCC[C@@](C)(C=C)/C=C/C1=CC=C(C=C1)O)C

> <pd_targets>
{EPAS1,HIF1A}

> <pathway_gtopdb>
{"Transcription factor"}

> <pathway_chembl>
{}

> <pathway_reactome>
{}

> <broad_targets>
{HIF1A}

> <broad_moa>
{"DNA polymerase inhibitor"}

> <synonyms>
{Bakuchiol,10309-37-2,10309372,(+)-Bakuchiol,(+)Bakuchiol,UNII-OT12HJU3AR,UNIIOT12HJU3AR,(S)-Bakuchiol,(S)Bakuchiol,C18H24O,OT12HJU3AR,"4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol","4(3Ethenyl3,7d
imethyl1,6octadienyl)phenol","Phenol, 4-((1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadienyl)-","Phenol, 4((1E,3S)3ethenyl3,7dimethyl1,6octadienyl)","UP 256",4-(3,4(3,7-Dimethyl-3-vinylocta-1,7Dimethyl3viny
locta1,6-dien-1-y,6dien1y,T3400}

> <pdid>
PD012036

> <targets>
{"Immunology & Inflammation related","DNA polymerase I",Autophagy,"p38 MAPK"}

> <classes>
{DNA Damage/DNA Repair,Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{5468522}

$$$$
UTKinase_V5
  SciTegic11012413002D

 44 47  0  0  1  0            999 V2000
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
    1.2990    0.7500    0.0000 C   0  0  2  0  0  0
    2.6003    1.4978    0.0000 O   0  0
    3.8990    0.7455    0.0000 C   0  0
    3.8964   -0.7545    0.0000 O   0  0
    5.2003    1.4932    0.0000 C   0  0
    6.4990    0.7410    0.0000 C   0  0
    7.8003    1.4887    0.0000 C   0  0
    9.0994    0.7388    0.0000 C   0  0
   10.3984    1.4888    0.0000 C   0  0
   11.6975    0.7387    0.0000 O   0  0
   10.3985    2.9888    0.0000 C   0  0
   11.6975    3.7387    0.0000 O   0  0
    9.0994    3.7388    0.0000 C   0  0
    7.8004    2.9888    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0  2  0  0  0
   -1.2990    0.7500    0.0000 O   0  0
   -1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
   -2.6003   -1.4978    0.0000 O   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -5.2003   -1.4932    0.0000 C   0  0
   -6.4990   -0.7410    0.0000 C   0  0
   -7.8007   -1.4864    0.0000 C   0  0
   -9.0971   -0.7319    0.0000 C   0  0
   -9.0919    0.7681    0.0000 C   0  0
   -7.7903    1.5136    0.0000 C   0  0
   -6.4939    0.7591    0.0000 C   0  0
   -7.7851    3.0136    0.0000 O   0  0
  -10.3884    1.5225    0.0000 O   0  0
    0.0000   -1.5000    0.0000 C   0  0  2  0  0  0
    0.0000   -3.0000    0.0000 O   0  0
    0.0031    3.0008    0.0000 C   0  0
    1.3032    3.7490    0.0000 O   0  0
    2.5951   -3.0039    0.0000 C   0  0  2  0  0  0
    1.2935   -3.7495    0.0000 O   0  0
    1.2883   -5.2495    0.0000 C   0  0  2  0  0  0
    2.5847   -6.0040    0.0000 C   0  0  2  0  0  0
    2.5796   -7.5040    0.0000 O   0  0
    3.8864   -5.2585    0.0000 C   0  0  1  0  0  0
    5.1828   -6.0130    0.0000 O   0  0
    3.8915   -3.7585    0.0000 C   0  0  1  0  0  0
    5.1932   -3.0130    0.0000 O   0  0
   -0.0133   -5.9950    0.0000 C   0  0
  2  1  1  6
  2  3  1  0
  3  4  1  1
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16  9  1  0
  3 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  6
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 27 29  1  0
 26 30  1  0
 19 31  1  0
 31  2  1  0
 31 32  1  1
 17 33  1  6
 33 34  1  0
 35  1  1  1
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 39  1  1
 38 40  1  0
 40 41  1  6
 40 42  1  0
 42 35  1  0
 42 43  1  6
 37 44  1  6
M  END
> <name>
UTKinase_V5

> <id>
28972

> <plate>
Kinase v5-3

> <well>
N15

> <supplier_cmpd_name>
Verbascoside

> <ctcr_id>
11602

> <supplier_cmpd_id>
S5458

> <smiles>
O([C@H]1[C@H](OC(=O)/C=C/c2cc(O)c(O)cc2)[C@H](O[C@@H](OCCc2ccc(c(c2)O)O)[C@@H]1O)CO)[C@@H]1O[C@H]([C@H](O)[C@@H](O)[C@H]1O)C

> <pd_targets>
{PRKCA,PRKCB,PRKCD,PRKCE,PRKCG,PRKCH,PRKCQ,PRKCZ,L3MBTL1,REP,PTGS2,POL}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator",Kinase,Reader,Transferase,Oxidoreductase,Hydrolase,"Protein Kinase","Methyl-lysine/arginine binding protein","AGC protein kinase group","MBT domain","AGC protein kinase 
PKC family","AGC protein kinase PKC alpha subfamily"}

> <pathway_chembl>
{"Other protein targets",Enzymes,"Anti-infective targets","Eicosanoid turnover","Kinases (EC 2.7.x.x)","Viral protein targets",Cyclooxygenase,"AGC: Containing PKA",PKG,"PKC families","Coronavirus (CoV
) proteins","Protein kinase C (PKC) family","Delta subfamily"}

> <pathway_reactome>
{"Gene expression (Transcription)",Disease,Metabolism,"Signal Transduction","RNA Polymerase II Transcription","Infectious disease","Metabolism of lipids","Signaling by GPCR","Generic Transcription Pat
hway","SARS-CoV Infections","Biosynthesis of specialized proresolving mediators (SPMs)","GPCR downstream signalling","Transcriptional Regulation by TP53","SARS-CoV-2 Infection","Biosynthesis of DPA-de
rived SPMs","G alpha (i) signalling events","Regulation of TP53 Activity","SARS-CoV-2 Genome Replication and Transcription","Biosynthesis of DPAn-3 SPMs","Visual phototransduction","Regulation of TP53
 Activity through Methylation","Replication of the SARS-CoV-2 genome","The phototransduction cascade",Inactivation,"recovery and regulation of the phototransduction cascade"}

> <broad_targets>
{}

> <broad_moa>
{"NFkB pathway inhibitor","PKC inhibitor"}

> <synonyms>
{Acteoside,Verbascoside,61276-17-3,61276173,Kusaginin,Verbacoside,"TJC 160",UNII-3TGX09BD5B,UNII3TGX09BD5B,acetoside,"NSC 603831",3TGX09BD5B,Verbacoside;,Acteoside;,MFCD00221751,MLS002473233,SCHEMBL65
7970,CHEBI:9953,CHEMBL231853,CHEMBL444478,cid_5281800,cid5281800,cid-5281800,"cid 5281800",T3375}

> <pdid>
PD012066

> <targets>
{"Immunology & Inflammation related",p53,PARP1,PKC,Apoptosis,Bacterial,HSV}

> <classes>
{Chromatin/Epigenetic,Apoptosis,Cytoskeletal Signaling,DNA Damage/DNA Repair,Anti-infection,Epigenetics,TGF-beta/Smad}

> <pubchem_cids>
{5281800}

$$$$
UTKinase_V5
  SciTegic11012413002D

 38 44  0  0  0  0            999 V2000
    5.9821    0.3199    0.0000 N   0  0
    6.2343   -1.1588    0.0000 C   0  0
    7.5748   -1.8319    0.0000 N   0  0
    7.3489   -3.3148    0.0000 C   0  0
    8.4123   -4.3702    0.0000 N   0  0
    8.0303   -5.8216    0.0000 C   0  0
    9.0935   -6.8797    0.0000 C   0  0
    8.7088   -8.3296    0.0000 C   0  0
    7.2599   -8.7222    0.0000 C   0  0
    7.0956  -10.2131    0.0000 C   0  0
    5.8274  -11.0143    0.0000 C   0  0
    4.4104  -10.5223    0.0000 C   0  0
    3.9116   -9.1076    0.0000 C   0  0
    4.7066   -7.8356    0.0000 C   0  0
    6.1967   -7.6641    0.0000 C   0  0
    6.5823   -6.2134    0.0000 C   0  0
    3.3518  -11.5860    0.0000 N   0  0
    3.6830  -13.0397    0.0000 C   0  0
    2.3865  -13.7940    0.0000 C   0  0
    1.2684  -12.7940    0.0000 C   0  0
    1.8740  -11.4217    0.0000 C   0  0
    5.8687   -3.5582    0.0000 N   0  0
    5.2015   -2.2290    0.0000 N   0  0
    3.7175   -2.0053    0.0000 C   0  0
    3.1695   -0.6090    0.0000 C   0  0
    1.6852   -0.3846    0.0000 C   0  0
    1.3514    1.0778    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -3.1695   -0.6090    0.0000 C   0  0
   -3.7175   -2.0053    0.0000 C   0  0
   -2.7822   -3.1781    0.0000 C   0  0
   -1.2990   -2.9545    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0
    1.2990   -2.9545    0.0000 N   0  0
    2.7822   -3.1780    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15  9  1  0
 15 16  2  0
 16  6  1  0
 12 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 17  1  0
  4 22  2  0
 22 23  1  0
 23  2  1  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
 35 36  1  0
 36 26  2  0
 36 37  1  0
 37 38  2  0
 38 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28973

> <plate>
Kinase v5-3

> <well>
N17

> <supplier_cmpd_name>
R428 (BGB324)

> <ctcr_id>
2080

> <supplier_cmpd_id>
S2841

> <smiles>
Nc1nc(Nc2ccc3CCC(CCc3c2)N4CCCC4)nn1c5cc6CCCc7ccccc7c6nn5

> <pd_targets>
{AXL,FLT3,EGFR,ALK,SRC,RET,KIT,TYRO3,MERTK,AURKA,MET,AURKB,DDR1,KDR,PDGFRA}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Other protein kinase group","Tyrosine protein kinase Axl family","Tyrosine protein kinase PDGFR family","Tyrosine 
protein kinase EGFR family","TKL protein kinase STKR family","Tyrosine protein kinase Src family","Tyrosine protein kinase Ret family","Other protein kinase AUR family","Tyrosine protein kinase Met fa
mily","Tyrosine protein kinase DDR family","Tyrosine protein kinase VEGFR family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Other protein kinases","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Aurora kinase (Aur) family
","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type XIX RTKs: Le
ukocyte tyrosine kinase (LTK) receptor family","Src family","Type XIV RTKs: RET","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Type IV 
RTKs: VEGF (vascular endothelial growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Developmental Biology",Disease,Hemostasis,"Gene expression (Transcription)","Cell Cycle","Extracellular matrix organization","Signaling by Receptor Tyrosine Kinases","Signaling
 by GPCR","Nervous system development","Diseases of signal transduction by growth factor receptors and second messengers","Cell surface interactions at the vascular wall","RNA Polymerase II Transcript
ion",Mitotic,"Non-integrin membrane-ECM interactions","Signaling by VEGF","Signaling by Insulin receptor","GPCR downstream signalling","Signaling by NTRKs","Axon guidance","Signaling by KIT in disease
","Generic Transcription Pathway","M Phase","Signaling by PDGFR in disease","VEGFA-VEGFR2 Pathway","Insulin receptor signalling cascade","G alpha (q) signalling events","Signaling by NTRK1 (TRKA)","RE
T signaling","Drug resistance of KIT mutants","Transcriptional Regulation by TP53","Semaphorin interactions","Mitotic Metaphase and Anaphase","Drug resistance of PDGFR mutants","IRS-mediated signallin
g","Gastrin-CREB signalling pathway via PKC and MAPK","Signalling to ERKs","Dasatinib-resistant KIT mutants","Regulation of TP53 Activity","Sema4D in semaphorin signaling","Mitotic Anaphase","VEGFR2 m
ediated cell proliferation","Imatinib-resistant PDGFR mutants","PI3K Cascade","EGFR Transactivation by Gastrin","Signalling to RAS","Regulation of TP53 Activity through Phosphorylation","Sema4D mediat
ed inhibition of cell attachment and migration","Separation of Sister Chromatids","p38MAPK events"}

> <broad_targets>
{AXL}

> <broad_moa>
{"AXL kinase inhibitor"}

> <synonyms>
{CHEMBL2023349,SCHEMBL467860,"R428 (BGB324; Bemcentinib)",BDBM50382441,NSC765262,NSC-765262,NCGC00389622-01,NCGC0038962201,AK473980,1037624-91-1,1037624911,SY-R428,S2841,R428,"R428 (BGB324)"}

> <pdid>
PD003525

> <targets>
{AXL,Axl}

> <classes>
{}

> <pubchem_cids>
{25127414}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -3.6065    0.0000    0.0000 N   0  0
   -2.7248    1.2135    0.0000 C   0  0
   -3.0337    2.1646    0.0000 O   0  0
   -5.1046   -0.0020    0.0000 C   0  0
   -5.8529   -1.3030    0.0000 C   0  0
   -7.3529   -1.3050    0.0000 O   0  0
   -5.1011   -2.6020    0.0000 N   0  0
   -5.8494   -3.9030    0.0000 C   0  0
   -5.2289   -5.2546    0.0000 S   0  0
   -6.3440   -6.2579    0.0000 C   0  0
   -7.6428   -5.5074    0.0000 C   0  0
   -7.3303   -4.0403    0.0000 N   0  0
   -5.8564    1.2969    0.0000 C   0  0
   -7.3564    1.2924    0.0000 C   0  0
   -8.1104    2.5892    0.0000 C   0  0
   -7.3644    3.8905    0.0000 C   0  0
   -5.8644    3.8951    0.0000 C   0  0
   -5.1104    2.5983    0.0000 C   0  0
   -4.1104    2.6014    0.0000 O   0  0
   -9.6104    2.5846    0.0000 F   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9  4  1  0
  9 10  2  0
  8 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 15  2  0
 11 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 20  1  0
 25 26  1  0
 22 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
28974

> <plate>
Kinase v5-3

> <well>
P19

> <supplier_cmpd_name>
EAI045

> <ctcr_id>
11548

> <supplier_cmpd_id>
S8242

> <smiles>
c1ccc2c(c1)CN(C2=O)C(C(=O)Nc1sccn1)c1cc(ccc1O)F

> <pd_targets>
{EGFR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Signaling by GPCR","GPCR downstream signalling","G alpha (q) signalling events","Gastrin-CREB signalling pathway via PKC and MAPK","EGFR Transactivation by Gastrin"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{EAI045,1942114-09-1,1942114091,EAI-045,CHEMBL4214567,GTPL9222,SCHEMBL18472992,AMY9112,BCP17698,EX-A1735,EXA1735,BDBM50453891,s8242,AKOS030573300,CCG-268438,CCG268438,CS-5835,CS5835,AC-29880,AC29880,A
K607730,AS-55933,AS55933,HY-100213,HY100213,Q27077145,FC=1C=CC(=C(C=1)C(C(=O)NC=1SC=CN=1)N1C(C2=CC=CC=C2C1)=O),T6824}

> <pdid>
PD048224

> <targets>
{EGFR,"EGFR mutants"}

> <classes>
{Angiogenesis,"JAK/STAT signaling","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{121231412}

$$$$
UTKinase_V5
  SciTegic11012413002D

 29 31  0  0  0  0            999 V2000
    2.5875   -5.9994    0.0000 C   0  0
    3.8888   -5.2533    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    6.4963   -0.7535    0.0000 O   0  0
    6.4965    0.7465    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 N   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -3.8971    3.7500    0.0000 N   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -2.6016   -2.9971    0.0000 O   0  0
   -1.3070   -5.2502    0.0000 N   0  0
   -2.6078   -5.9988    0.0000 C   0  0
   -2.6109   -7.4988    0.0000 C   0  0
   -3.9083   -6.7463    0.0000 C   0  0
   -3.9055   -5.2465    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  5  8  2  0
  8  9  1  0
  9 10  2  0
 10  3  1  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 13  1  0
 19 20  1  0
 20 21  2  0
 21 11  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  1  0
 26 27  1  0
 26 28  1  0
 26 29  1  0
M  END
> <name>
UTKinase_V5

> <id>
28978

> <plate>
Kinase v5-3

> <well>
P09

> <supplier_cmpd_name>
PD-166866 (PD166866)

> <ctcr_id>
12562

> <supplier_cmpd_id>
S8493

> <smiles>
COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C

> <pd_targets>
{FGFR1,FGFR2,FGFR3,FGFR4,EGFR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase FGFR family","Tyrosine protein kinase EGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family","Type V RTKs: FGF (fibroblast
 growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Signaling by GPCR","Diseases of signal transduction by growth factor receptors and second messengers","GPCR downstream signalling","Signaling by FGFR in disease","G alp
ha (q) signalling events","Signaling by FGFR1 in disease","Gastrin-CREB signalling pathway via PKC and MAPK","FGFR1 mutant receptor activation","EGFR Transactivation by Gastrin","Signaling by activate
d point mutants of FGFR1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{D16686,192705-79-6,192705796,PD-166866,PD166866,"PD 166866",UNII-NA856793UT,UNIINA856793UT,CHEMBL299763,NA856793UT,"6-arylpyrido(2,3-d)pyrimidine deriv. 25","6arylpyrido(2,3d)pyrimidine deriv. 25","P
D-166866 (PD166866)","PD166866 (PD166866)",BDBM3443,SCHEMBL1248489,DTXSID20416144,CHEBI:156259,HMS3263L17,BCP20054,EX-A1324,EXA1324,ZINC1546258,Tox2,T3492}

> <pdid>
PD015690

> <targets>
{FGFR,FGFR1}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{5328127}

$$$$
UTKinase_V5
  SciTegic11012413002D

 45 50  0  0  0  0            999 V2000
    3.2490  -14.9014    0.0000 C   0  0
    4.0964  -13.6637    0.0000 O   0  0
    3.4487  -12.3098    0.0000 C   0  0
    4.2965  -11.0714    0.0000 C   0  0
    3.6488   -9.7176    0.0000 N   0  0
    4.4967   -8.4792    0.0000 C   0  0
    3.8490   -7.1253    0.0000 C   0  0
    4.6946   -5.8864    0.0000 C   0  0
    4.0445   -4.5346    0.0000 N   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.7031   -5.6606    0.0000 C   0  0
    2.3532   -7.0124    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.3114   -2.9665    0.0000 S   0  0
   -2.6003   -1.4978    0.0000 O   0  0
   -3.8990   -0.7455    0.0000 C   0  0
   -5.2007   -1.4909    0.0000 C   0  0
   -6.4972   -0.7365    0.0000 C   0  0
   -6.4920    0.7635    0.0000 C   0  0
   -5.1903    1.5090    0.0000 C   0  0
   -3.8939    0.7546    0.0000 C   0  0
   -7.7876    1.5211    0.0000 N   0  0
   -7.7803    3.0219    0.0000 C   0  0
   -6.4773    3.7652    0.0000 O   0  0
   -9.0758    3.7795    0.0000 C   0  0
  -10.4601    3.8535    0.0000 C   0  0
   -9.7171    2.5505    0.0000 C   0  0
   -9.0681    5.2807    0.0000 C   0  0
   -7.7649    6.0235    0.0000 O   0  0
  -10.3634    6.0387    0.0000 N   0  0
  -10.3556    7.5395    0.0000 C   0  0
  -11.6492    8.2989    0.0000 C   0  0
  -11.6383    9.7989    0.0000 C   0  0
  -10.3339   10.5395    0.0000 C   0  0
   -9.0403    9.7801    0.0000 C   0  0
   -9.0512    8.2801    0.0000 C   0  0
  -10.3231   12.0394    0.0000 F   0  0
   -5.2059   -2.9909    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  3
 12  7  1  0
 10 13  1  0
 13 14  2  3
 14 15  1  0
 15 16  2  3
 16 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 15  1  0
 20 21  1  0
 21 13  1  0
 19 22  1  0
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  3
 26 27  1  0
 27 28  2  3
 28 23  1  0
 26 29  1  0
 29 30  1  0
 30 31  2  0
 30 32  1  0
 32 33  1  0
 33 34  1  0
 34 32  1  0
 32 35  1  0
 35 36  2  0
 35 37  1  0
 37 38  1  0
 38 39  2  3
 39 40  1  0
 40 41  2  3
 41 42  1  0
 42 43  2  3
 43 38  1  0
 41 44  1  0
 24 45  1  0
M  END
> <name>
UTKinase_V5

> <id>
28979

> <plate>
Kinase v5-3

> <well>
P11

> <supplier_cmpd_name>
Sitravatinib (MGCD516)

> <ctcr_id>
12708

> <supplier_cmpd_id>
S8573

> <smiles>
COCCNCC1=CN=C(C=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

> <pd_targets>
{EPHA3,KDR,KIT,NTRK1,DDR2,FLT3,MET,PDGFRA,FLT4,AXL,MERTK,FLT1,NTRK2,RET,NTRK3}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Eph family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase Tr
k family","Tyrosine protein kinase DDR family","Tyrosine protein kinase Met family","Tyrosine protein kinase Axl family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XIII RTKs: Ephrin receptor family","Type IV RTKs: VEGF (vascular endothelial growth f
actor) receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type VII RTKs: Neurotrophin receptor/Trk family","Type XVI RTKs: DDR (collagen receptor) family","Type X RTKs: HGF (hepa
tocyte growth factor) receptor family","Type XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Signal Transduction",Disease,"Extracellular matrix organization",Hemostasis,"Nervous system development","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduc
tion by growth factor receptors and second messengers","Non-integrin membrane-ECM interactions","Cell surface interactions at the vascular wall","Axon guidance","Signaling by VEGF","Signaling by KIT i
n disease","Signaling by NTRKs","Signaling by Insulin receptor","Signaling by PDGFR in disease","EPH-Ephrin signaling","VEGFA-VEGFR2 Pathway","Drug resistance of KIT mutants","Signaling by NTRK1 (TRKA
)","Insulin receptor signalling cascade","Semaphorin interactions","Drug resistance of PDGFR mutants","VEGF ligand-receptor interactions","Signaling by NTRK3 (TRKC)","EPHA-mediated growth cone collaps
e","VEGFR2 mediated cell proliferation","Dasatinib-resistant KIT mutants","Signalling to ERKs","IRS-mediated signalling","Sema4D in semaphorin signaling","Imatinib-resistant PDGFR mutants","VEGF binds
 to VEGFR leading to receptor dimerization","Activation of TRKA receptors","Activated NTRK3 signals through PI3K","Prolonged ERK activation events","PI3K Cascade","Sema4D mediated inhibition of cell a
ttachment and migration","NGF-independant TRKA activation","ARMS-mediated activation"}

> <broad_targets>
{}

> <broad_moa>
{"receptor tyrosine protein kinase inhibitor"}

> <synonyms>
{Sitravatinib,1123837-84-2,1123837842,MGCD516,MG-516,MG516,"Sitravatinib (MGCD516)",MGCD-516,UNII-CWG62Q1VTB,UNIICWG62Q1VTB,CWG62Q1VTB,MG-91516,MG91516,"Sitravatinib (INN)","Sitravatinib (USAN/INN)","
Sitravatinib (USAN:INN)",SCHEMBL172015,GCD516,GTPL9920,CHEMBL3989926,MGCD516;,T4349}

> <pdid>
PD052686

> <targets>
{"Ephrin receptor",c-Kit,"TAM Receptor",VEGFR,"Trk receptor",DDR2,EPHA3,Axl,Mer,"VEGFR3 (FLT4)","Discoidin Domain Receptor",FLT3,"Trk Receptor"}

> <classes>
{Tyrosine Kinase/Adaptors,Neuronal Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{25212148}

$$$$
UTKinase_V5
  SciTegic11012413002D

 46 49  0  0  0  0            999 V2000
    0.0007    0.0004    0.0000 C   0  0
    1.3000    0.7500    0.0000 C   0  0
    2.6000    0.0000    0.0000 S   0  0
    3.8993    0.7496    0.0000 O   0  0
    2.6000   -1.5000    0.0000 O   0  0
    3.8989   -0.7502    0.0000 O   0  0
   13.5383   -9.6970    0.0000 C   0  0
   14.5460   -8.5859    0.0000 N   0  0
   16.0121   -8.9030    0.0000 C   0  0
   17.0198   -7.7920    0.0000 C   0  0
   16.5615   -6.3637    0.0000 N   0  0
   15.0953   -6.0465    0.0000 C   0  0
   14.0876   -7.1576    0.0000 C   0  0
   17.5675   -5.2499    0.0000 C   0  0
   17.1069   -3.8215    0.0000 C   0  0
   15.6403   -3.5069    0.0000 O   0  0
   18.1129   -2.7078    0.0000 N   0  0
   19.5795   -3.0224    0.0000 C   0  0
   17.6523   -1.2794    0.0000 C   0  0
   18.6561   -0.1648    0.0000 C   0  0
   18.1928    1.2619    0.0000 C   0  0
   16.7256    1.5740    0.0000 C   0  0
   15.7218    0.4594    0.0000 C   0  0
   16.1851   -0.9673    0.0000 C   0  0
   16.2592    3.0005    0.0000 N   0  0
   14.7908    3.3107    0.0000 C   0  0
   14.3251    4.7348    0.0000 C   0  0
   12.8993    5.1983    0.0000 C   0  0
   12.8993    6.6983    0.0000 C   0  0
   11.6003    7.4483    0.0000 C   0  0
   10.3013    6.6983    0.0000 C   0  0
   10.3013    5.1983    0.0000 C   0  0
   11.6003    4.4483    0.0000 C   0  0
    8.9999    7.4460    0.0000 C   0  0
    8.9973    8.9460    0.0000 O   0  0
    7.7013    6.6938    0.0000 O   0  0
    6.4007    7.4411    0.0000 C   0  0
   14.3251    7.1618    0.0000 N   0  0
   15.2067    5.9483    0.0000 C   0  0
   16.7067    5.9483    0.0000 O   0  0
   13.7883    2.1939    0.0000 C   0  0
   12.3201    2.5014    0.0000 C   0  0
   11.3197    1.3837    0.0000 C   0  0
   11.7874   -0.0415    0.0000 C   0  0
   13.2555   -0.3491    0.0000 C   0  0
   14.2559    0.7686    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  2  0
  3  6  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13  8  1  0
 11 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  2  3
 20 21  1  0
 21 22  2  3
 22 23  1  0
 23 24  2  3
 24 19  1  0
 22 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  3
 29 30  1  0
 30 31  2  3
 31 32  1  0
 32 33  2  3
 33 28  1  0
 31 34  1  0
 34 35  2  0
 34 36  1  0
 36 37  1  0
 29 38  1  0
 38 39  1  0
 39 27  1  0
 39 40  2  0
 26 41  1  0
 41 42  2  3
 42 43  1  0
 43 44  2  3
 44 45  1  0
 45 46  2  3
 46 41  1  0
M  END
> <name>
UTKinase_V5

> <id>
28980

> <plate>
Kinase v5-3

> <well>
P13

> <supplier_cmpd_name>
Nintedanib Ethanesulfonate Salt

> <ctcr_id>
11396

> <supplier_cmpd_id>
S5234

> <smiles>
CCS(=O)(=O)O.CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{FGFR1,FGFR2,FGFR3,FGFR4,FLT1,FLT4,KDR,PDGFRA,PDGFRB}

> <broad_moa>
{"FGFR inhibitor","PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{"Nintedanib esylate",656247-18-6,656247186,"BIBF 1120 esylate","Nintedanib Ethanesulfonate Salt","Nintedanib ethanesulfonate",UNII-42F62RTZ4G,UNII42F62RTZ4G,"656247-18-6 (esylate)","656247186 (esylat
e)",OFEV,42F62RTZ4G,CHEBI:85170,"BIBF 1120 (esylate)","Nintedanib Esilate",SCHEMBL,T5001}

> <pdid>
PD003643

> <targets>
{VEGFR,FGFR,PDGFR,VEGFR1/2/3,FGFR1/2/3,PDGFR¦Á/¦Â}

> <classes>
{"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{135476717}

$$$$
UTKinase_V5
  SciTegic11012413002D

 25 28  0  0  0  0            999 V2000
    3.8912   -5.2570    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -5.0114   -1.7530    0.0000 C   0  0
   -4.4013   -3.1233    0.0000 C   0  0
   -2.9095   -2.9665    0.0000 O   0  0
   -5.2818   -4.3363    0.0000 C   0  0
   -6.7736   -4.1795    0.0000 C   0  0
   -7.3837   -2.8092    0.0000 C   0  0
   -6.5020   -1.5957    0.0000 C   0  0
   -7.6553   -5.3931    0.0000 O   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1962    1.5000    0.0000 O   0  0
   -2.5981    1.5000    0.0000 O   0  0
    2.5981    1.5000    0.0000 O   0  0
    5.1937   -3.0093    0.0000 C   0  0
  1  2  1  0
  2  3  2  3
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  5  1  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 11  1  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 13  1  0
 17 20  1  0
 12 21  1  0
 21 22  2  0
 21 23  1  0
 23  8  1  0
  6 24  1  0
  2 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
28981

> <plate>
Kinase v5-3

> <well>
P15

> <supplier_cmpd_name>
Psoralidin

> <ctcr_id>
12598

> <supplier_cmpd_id>
S5464

> <smiles>
CC(=CCc1c(cc2c(c1)c1c(c3c(o1)cc(cc3)O)c(=O)o2)O)C

> <pd_targets>
{ALOX5AP}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein"}

> <pathway_chembl>
{"Other protein targets","Anti-infective targets","Viral protein targets","Coronavirus (CoV) proteins"}

> <pathway_reactome>
{Disease,Metabolism,"Infectious disease","Metabolism of lipids","SARS-CoV Infections","Fatty acid metabolism","SARS-CoV-1 Infection","Arachidonic acid metabolism","SARS-CoV-1 Genome Replication and Tr
anscription","Synthesis of 5-eicosatetraenoic acids","Replication of the SARS-CoV-1 genome"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Psoralidin,18642-23-4,18642234,"3,9-Dihydroxy-2-prenylcoumestan","3,9Dihydroxy2prenylcoumestan",UNII-G16ZUQ069L,UNIIG16ZUQ069L,G16ZUQ069L,"3,9-dihydroxy-2-(3-methylbut-2-enyl)-(1)benzofuro(3,2-c)chro
men-6-one","3,9dihydroxy2(3methylbut2enyl)(1)benzofuro(3,2c)chromen6one","Psoralidin (5)",3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro(3,9Dihydroxy2(3methyl2butenyl)6Hbenzofuro(3,2-c)(1)benzopyra
n-6,2c)(1)benzopyran6,T3399}

> <pdid>
PD019002

> <targets>
{"Estrogen/progestogen Receptor",Akt,"Phosphatidylinositol 3-kinase",Bacterial,COX,Lipoxygenase,Notch,"Reactive Oxygen Species"}

> <classes>
{Cytoskeletal Signaling,Others,PI3K/Akt/mTOR signaling,Anti-infection,Immunology/Inflammation,Metabolic Enzyme/Protease,Neuronal Signaling,NF-ºB,Stem Cell/Wnt}

> <pubchem_cids>
{5281806}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 26  0  0  0  0            999 V2000
    0.0007    0.0004    0.0000 C   0  0
    1.3000    0.7500    0.0000 C   0  0
    2.6000    0.0000    0.0000 C   0  0
    3.9000    0.7500    0.0000 C   0  0
    5.2000    0.0000    0.0000 C   0  0
    6.5000    0.7500    0.0000 C   0  0
    7.7999    0.0000    0.0000 C   0  0
    9.0999    0.7500    0.0000 C   0  0
   10.3999    0.0000    0.0000 C   0  0
   11.6999    0.7500    0.0000 C   0  0
   12.9999    0.0000    0.0000 C   0  0
   14.2999    0.7500    0.0000 C   0  0
   15.5999    0.0000    0.0000 C   0  0
   16.8999    0.7500    0.0000 C   0  0
   18.1999    0.0000    0.0000 C   0  0
   19.4998    0.7500    0.0000 C   0  0
   20.7998    0.0000    0.0000 O   0  0
   22.0998    0.7500    0.0000 P   0  0
   22.0998    2.2500    0.0000 O   0  5
   20.8009    1.5002    0.0000 O   0  0
   23.3998    0.0000    0.0000 O   0  0
   24.6998    0.7500    0.0000 C   0  0
   25.9998    0.0000    0.0000 C   0  0
   27.2998    0.7500    0.0000 N   0  3
   28.5991    0.0004    0.0000 C   0  0
   27.2998    2.2500    0.0000 C   0  0
   28.5987    1.5002    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 18 20  2  0
 18 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
M  CHG  2  19  -1  24   1
M  END
> <name>
UTKinase_V5

> <id>
28982

> <plate>
Kinase v5-3

> <well>
B04

> <supplier_cmpd_name>
Miltefosine

> <ctcr_id>
4275

> <supplier_cmpd_id>
S3056

> <smiles>
CCCCCCCCCCCCCCCCO[P]([O-])(=O)OCC[N+](C)(C)C

> <pd_targets>
{FTL,LMNA,HEXB,CDC25A,AKT1}

> <pathway_gtopdb>
{"Unclassified protein","Other nuclear protein",Enzyme,Hydrolase,Phosphatase,Protease,Kinase,"Protein Phosphatase","Cysteine protease","Protein Kinase","Serine/threonine/tyrosine protein phosphatase",
"Cysteine protease CA clan","AGC protein kinase group","Cysteine protease C1A family","AGC protein kinase AKT family"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","AGC: Containing PKA",PKG,"PKC families","Akt (Protein kinase B","PKB) family"}

> <pathway_reactome>
{"Vesicle-mediated transport","Cell Cycle",Disease,"Gene expression (Transcription)","Membrane Trafficking",Mitotic,"Diseases of metabolism","Cell Cycle Checkpoints","RNA Polymerase II Transcription",
"trans-Golgi Network Vesicle Budding","M Phase","Diseases of glycosylation","G1/S DNA Damage Checkpoints","Generic Transcription Pathway","Golgi Associated Vesicle Biogenesis","Mitotic Metaphase and A
naphase","Diseases associated with glycosaminoglycan metabolism","p53-Independent G1/S DNA damage checkpoint","Transcriptional Regulation by TP53","Mitotic Anaphase","Defective HEXB causes GM2G2","p53
-Independent DNA Damage Response","Regulation of TP53 Activity","Nuclear Envelope (NE) Reassembly","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A","Regulation of TP53 Expression and Degradat
ion","Initiation of Nuclear Envelope (NE) Reformation","Regulation of TP53 Degradation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{"Choline, inner salt",Miltefosine,58066-85-6,58066856,Hexadecylphosphocholine,Miltex,Impavido,Hexadecylphosphorylcholine,HDPC,n-Hexadecylphosphorylcholine,nHexadecylphosphorylcholine,Miltefosinum,Mil
tefosina,"hexadecyl 2-(trimethylammonio)ethyl phosphate","hexadecyl 2(trimethylammonio)ethyl phosphate",1-Hexadecylphosphorylch,1Hexadecylphosphorylch,T0033,NSC605583,1505329,"NSC 605583",MILTEFOSINE,
"Miltefosin C"}

> <pdid>
PD000933

> <targets>
{Akt,HIV}

> <classes>
{antineoplastic,Anti-infection,PI3K/Akt/mTOR}

> <pubchem_cids>
{3599}

$$$$
UTKinase_V5
  SciTegic11012413002D

 32 31  0  0  0  0            999 V2000
   11.6982   -0.7323    0.0000 C   0  0
   10.4003   -1.4841    0.0000 C   0  0
    9.0990   -0.7364    0.0000 N   0  0
    9.0933    0.7644    0.0000 C   0  0
    7.7919    1.5103    0.0000 C   0  0
    7.8003   -1.4887    0.0000 C   0  0
    6.4990   -0.7409    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 Cl  0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   14.1997   -1.8694    0.0000 O   0  0
   15.4989   -1.1198    0.0000 P   0  0
   15.4989    0.3802    0.0000 O   0  0
   15.4989   -2.6198    0.0000 O   0  0
   16.7982   -1.8694    0.0000 O   0  0
   19.2996   -1.8694    0.0000 O   0  0
   20.5989   -1.1198    0.0000 P   0  0
   20.5989    0.3802    0.0000 O   0  0
   20.5989   -2.6198    0.0000 O   0  0
   21.8982   -1.8694    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  3  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 18 20  2  0
 20 21  1  0
 21 22  2  0
 22 12  1  0
 22 16  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  2  0
 28 29  1  0
 29 30  1  0
 29 31  1  0
 29 32  2  0
M  END
> <name>
UTKinase_V5

> <id>
28983

> <plate>
Kinase v5-3

> <well>
D04

> <supplier_cmpd_name>
Chloroquine Phosphate

> <ctcr_id>
6784

> <supplier_cmpd_id>
S4157

> <smiles>
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.O[P](O)(O)=O.O[P](O)(O)=O

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{RESTW54,"Chloroquine diphosphate","Chloroquine phosphate",50-63-5,50635,"Aralen phosphate","Chloroquine bis(phosphate)","Chloroquine diphosphate salt",Arechin,Delagil,"Chloroquine (phosphate)","Ching
amin phosphate",Khingamin,Miniquine,Tanakan,Tanakene,Arale,T0194,1500179,Prestw-548,"CHLOROQUINE DIPHOSPHATE"}

> <pdid>

> <targets>
{Autophagy,ATM/ATR}

> <classes>
{antimalarial,antiamebic,antirheumatic,"intercalating agent"}

> <pubchem_cids>
{64927,43833344}

$$$$
UTKinase_V5
  SciTegic11012413002D

 22 23  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.6003    1.4977    0.0000 C   0  0
   -3.8990    0.7455    0.0000 C   0  0
   -3.8964   -0.7554    0.0000 C   0  0
   -3.8938   -2.2554    0.0000 N   0  0
   -5.2003    1.4932    0.0000 C   0  0
   -5.2029    2.9932    0.0000 O   0  0
   -6.4990    0.7409    0.0000 N   0  0
   -7.8003    1.4887    0.0000 C   0  0
   -9.0990    0.7364    0.0000 C   0  0
  -10.4007    1.4818    0.0000 C   0  0
  -11.6971    0.7273    0.0000 C   0  0
  -11.6919   -0.7727    0.0000 C   0  0
  -10.3903   -1.5182    0.0000 C   0  0
   -9.0939   -0.7637    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  5  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  3  0
 10 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
M  END
> <name>
UTKinase_V5

> <id>
28986

> <plate>
Kinase v5-3

> <well>
N21

> <supplier_cmpd_name>
AG-490

> <ctcr_id>
7554

> <supplier_cmpd_id>
S1143

> <smiles>
Oc1ccc(cc1O)\C=C(C#N)\C(=O)NCc2ccccc2

> <pd_targets>
{HIF1A,FFP,TP53,EGFR,KDM4E,SMN1,LMNA,MAPT,CYP2C19,ALOX15,CYP1A2,ALOX12,CHRM1,CYP3A4,GMNN,ERBB2,GRIN1,GRIN2B,GRIN2C,HSD17B10,FTL,KMT2A,MEN1,RECQL,BLM,JAK1,NFKB1,JAK3,PMP22,MAPK1,THPO,ALDH1A1,PKM,HPGD,L
EF,GRIN2A,MTOR,MAP4K2,PLK3,MKNK2,EEF2K,PRKD2,HIPK4,MINK1,MARK2,MAPKAPK2,PIM1,GSK3B,SLK,MAP4K5,PLK4,PRKAA1,TAOK1,IRAK1,AURKB,MAP3K20,AXL,GSK3A,PLK1}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Epigenetic regulator","Other nuclear protein","Other cytosolic protein","Membrane receptor","Unclassified protein","Ion channel",Transferase,Kinase,Eraser,Reader,"Cytoc
hrome P450",Oxidoreductase,"Family A G protein-coupled receptor","Ligand-gated ion channel",Protease,"Protein Kinase","Lysine demethylase","Methyl-lysine/arginine binding protein","Cytochrome P450 fam
ily 2","Cytochrome P450 family 1","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","Ionotropic glutamate receptor",Bromodomain,"Metallo protease","TK protein kinase group","Jumonji
 domain-containing","Tudor domain","Cytochrome P450 family 2C","Cytochrome P450 family 1A","Monoamine receptor","Cytochrome P450 family 3A","NMDA receptor","CMGC protein kinase group","Metallo proteas
e MAE clan","Atypical protein kinase group","Tyrosine protein kinase EGFR family","Cytochrome P450 2C19","Cytochrome P450 1A1","Acetylcholine receptor","Cytochrome P450 3A4","Tyrosine protein kinase J
akA family","CMGC protein kinase MAPK family","Metallo protease M34 family","Atypical protein kinase PIKK family","CMGC protein kinase ERK1","Atypical protein kinase FRAP subfamily","STE protein kinas
e group","Other protein kinase group","CAMK protein kinase group","TKL protein kinase group","STE protein kinase STE20 family","Other protein kinase PLK family","CAMK protein kinase MAPKAPK family","A
typical protein kinase alpha family","CAMK protein kinase PKD family","CMGC protein kinase DYRK family","CAMK protein kinase CAMK1 family","CAMK protein kinase PIM family","CMGC protein kinase GSK fam
ily","TKL protein kinase IRAK family","Other protein kinase AUR family","TKL protein kinase MLK family","Tyrosine protein kinase Axl family","STE protein kinase KHS subfamily","CAMK protein kinase MNK
 subfamily","CMGC protein kinase HIPK subfamily","STE protein kinase MSN subfamily","CAMK protein kinase MARK subfamily","CAMK protein kinase MAPKAPK subfamily","STE protein kinase SLK subfamily","CAM
K protein kinase AMPK subfamily","STE protein kinase TAO subfamily","TKL protein kinase MLK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Chromatin modifying enzymes","Cytochrome P450","Eicosanoid turnover","G protein-coupled receptors","Kinases (EC 2.7.x.x)","2.7.1.40 Pyruvate kinases","Recepto
r kinases","1.14.11.- Histone demethylases","CYP2 family: drug metabolising subset",Lipoxygenases,"CYP1 family","Acetylcholine receptors (muscarinic)","CYP3 family","CMGC: Containing CDK",MAPK,GSK3,"C
LK families","Prostaglandin synthases",Atypical,"TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases)","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Receptor tyrosi
ne kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","ERK subfamily","FRAP subfamily","Type I RTKs: ErbB (epidermal growth factor) receptor family","Janus kinase (JakA) family","STE: Homologs of
 yeast Sterile 7","Sterile 11","Sterile 20 kinases","CAMK: Calcium/calmodulin-dependent protein kinases","STE20 family","Other protein kinases","MAPK-Activated Protein Kinase (MAPKAPK) family","Alpha 
kinase family","Protein kinase D (PKD) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","CAMK-like (CAMKL) family","PIM family","Glycogen synthase kinase (GSK) fa
mily","TKL: Tyrosine kinase-like","KHS subfamily","Polo-like kinase (PLK) family","MKN subfamily","eEF2K subfamily","HIPK subfamily","MSN subfamily","MARK subfamily","MAPKAPK subfamily","GSK subfamily
","SLK subfamily","AMPK subfamily","TAO subfamily","Interleukin-1 receptor-associated kinase (IRAK) family","Aurora kinase (Aur) family","Mixed Lineage Kinase (MLK) family","MLK subfamily","Type XI RT
Ks: TAM (TYRO3-","AXL- and MER-TK) receptor family"}

> <pathway_reactome>
{"Cellular responses to external stimuli","Cell Cycle","Signal Transduction","Metabolism of RNA","Neuronal System",Metabolism,"Developmental Biology","Vesicle-mediated transport","DNA Repair","Immune 
System",Hemostasis,Disease,"Gene expression (Transcription)","Cellular responses to stress","Cell Cycle Checkpoints","Signaling by GPCR","Metabolism of non-coding RNA",Mitotic,"Transmission across Che
mical Synapses","Biological oxidations","Metabolism of lipids","Nervous system development","Metabolism of amino acids and derivatives","Membrane Trafficking","DNA Double-Strand Break Repair","Cytokin
e Signaling in Immune system","Innate Immune System","Platelet activation","signaling and aggregation","Metabolism of carbohydrates","Infectious disease","RNA Polymerase II Transcription","Cellular re
sponse to hypoxia","G1/S DNA Damage Checkpoints","GPCR downstream signalling","snRNP Assembly","M Phase","Neurotransmitter receptors and postsynaptic signal transmission","Phase I - Functionalization 
of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","GPCR ligand binding","Mitotic G1 phase and G1/S transition","Axon guidance","Branched-chain amino acid catabolism","trans-Gol
gi Network Vesicle Budding","Homology Directed Repair","Interferon Signaling","Signaling by Interleukins","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Toll-like Receptor Cascades"
,"Platelet Aggregation (Plug Formation)","Glucose metabolism","Uptake and actions of bacterial toxins","Generic Transcription Pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Fact
or Alpha","p53-Dependent G1/S DNA damage checkpoint","G alpha (q) signalling events","Mitotic Metaphase and Anaphase","Activation of NMDA receptors and postsynaptic events","Cytochrome P450 - arranged
 by substrate type","Biosynthesis of DPA-derived SPMs","Class A/1 (Rhodopsin-like receptors)","Biosynthesis of DHA-derived SPMs","G1/S Transition","Semaphorin interactions","Golgi Associated Vesicle B
iogenesis","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Antiviral mechanism by IFN-stimulated genes","Interleukin-1 family signaling","Interleukin-2 family signaling"
,"Toll Like Receptor 5 (TLR5) Cascade","Ethanol oxidation",Glycolysis,"Uptake and function of anthrax toxins","Transcriptional Regulation by TP53","p53-Dependent G1 DNA Damage Response","Gastrin-CREB 
signalling pathway via PKC and MAPK","Mitotic Anaphase","Post NMDA receptor activation events",Xenobiotics,"Biosynthesis of DPAn-3 SPMs","Amine ligand-binding receptors","Biosynthesis of maresins","Ac
tivation of the pre-replicative complex","Sema4D in semaphorin signaling","HDR through Homologous Recombination (HRR)","ISG15 antiviral mechanism","Interleukin-1 signaling","Interleukin-15 signaling",
"MyD88 cascade initiated on plasma membrane","Biosynthesis of D-series resolvins","Regulation of TP53 Activity","Stabilization of p53","EGFR Transactivation by Gastrin","Nuclear Envelope (NE) Reassemb
ly","Activation of AMPK downstream of NMDARs","CYP2E1 reactions","Biosynthesis of DPAn-3-derived protectins and resolvins","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Biosynthe
sis of DPAn-3-derived maresins","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","Sema4D induced cell migration and growth-cone collapse","Homologous DNA Pairing and Strand Exc
hange","MAP3K8 (TPL2)-dependent MAPK1/3 activation","MAP kinase activation","Regulation of TP53 Expression and Degradation","Autodegradation of the E3 ubiquitin ligase COP1","Initiation of Nuclear Env
elope (NE) Reformation","Presynaptic phase of homologous DNA pairing and strand exchange","MAPK targets/ Nuclear events mediated by MAP kinases","Regulation of TP53 Degradation","ERK/MAPK targets","ER
Ks are inactivated","MTOR signalling","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","mTORC1-mediated signalling","Sphingol
ipid metabolism","Cellular Senescence","FLT3 signaling in disease","SARS-CoV Infections","Mitotic G2-G2/M phases","Signaling by VEGF","Sphingolipid de novo biosynthesis","Oxidative Stress Induced Sene
scence","Signaling by FLT3 ITD and TKD mutants","SARS-CoV-1 Infection","G2/M Transition","VEGFA-VEGFR2 Pathway","STAT5 activation downstream of FLT3 ITD mutants","SARS-CoV-1 Genome Replication and Tra
nscription","Centrosome maturation","Regulation of TP53 Activity through Phosphorylation","Replication of the SARS-CoV-1 genome","Loss of proteins required for interphase microtubule organization from
 the centrosome","Separation of Sister Chromatids","Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK activation","CREB phosphorylation"}

> <broad_targets>
{EGFR,JAK2,JAK3}

> <broad_moa>
{"EGFR inhibitor","JAK inhibitor"}

> <synonyms>
{"G490 (TYRPHOSTIN B42",133550-30-8,133550308,AG-490,AG490,"Tyrphostin B42","AG 490","Tyrphostin AG 490","(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide","(E)Nbenzyl2cyano3(3,4dihydroxyphenyl)
acrylamide","Tyrphostin AG490","tyrphostin AG-490","tyrphostin AG490","AG-490 (Tyrphostin B42)","AG490 (Tyrphostin B42)",alpha-Cyano-(3,alphaCyano(3,4-dihydroxy)-N-benzy,4dihydroxy)Nbenzy,T2600,"EMD 6
58401",EI-272,414,S1143,658401}

> <pdid>
PD002602

> <targets>
{EGFR,JAK}

> <classes>
{}

> <pubchem_cids>
{5328779}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 30  0  0  0  0            999 V2000
    3.8919   -5.2525    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 O   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972   -0.1561    0.0000 N   0  0
   -5.7073   -1.5264    0.0000 C   0  0
   -4.8256   -2.7399    0.0000 C   0  0
   -3.3339   -2.5831    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 11  1  0
 10 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 19  1  0
 24 25  1  0
 25 17  1  0
 25 26  2  0
 26  8  1  0
M  END
> <name>
UTKinase_V5

> <id>
28987

> <plate>
Kinase v5-3

> <well>
P17

> <supplier_cmpd_name>
PI-103

> <ctcr_id>
3343

> <supplier_cmpd_id>
S1038

> <smiles>
Oc1cccc(c1)c2nc(N3CCOCC3)c4oc5ncccc5c4n2

> <pd_targets>
{CLK4,CDK7,PIP4K2C,JAK1,MYLK,PIK3CA,BRAF,DAPK2,PIK3CD,PIK3R1,RIOK2,PIK3CG,MTOR,PIK3CB,PRKDC,FLT3,TYK2,DYRK1B,PIM3,MAP3K19,PIK3C2B,DAPK3,PIK3C2G,LIMK2,RAF1,CDC42BPA,DAPK1,HIPK2,CSNK2A2,CLK3,DYRK2,PIK3C
2A,CHUK,CLK1,CLK2,CSNK2A1,PI4KB,HIPK3,HIPK1,MLST8,RPTOR,MAPKAP1,RICTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,Transferase,"Protein Kinase","CMGC protein kinase group","TK protein kinase group","CAMK protein kinase group","TKL protein kinase group","Atypical protein kinase group","STE protein ki
nase group","AGC protein kinase group","Other protein kinase group","CMGC protein kinase CLK family","CMGC protein kinase CDK family","Tyrosine protein kinase JakA family","CAMK protein kinase MLCK fa
mily","TKL protein kinase RAF family","CAMK protein kinase DAPK family","Atypical protein kinase RIO family","Atypical protein kinase PIKK family","Tyrosine protein kinase PDGFR family","CMGC protein 
kinase DYRK family","CAMK protein kinase PIM family","STE protein kinase STE11 family","TKL protein kinase LISK family","AGC protein kinase DMPK family","Other protein kinase CK2 family","Other protei
n kinase IKK family","CMGC protein kinase CDK7 subfamily","Atypical protein kinase RIO2 subfamily","Atypical protein kinase FRAP subfamily","CMGC protein kinase Dyrk1 subfamily","TKL protein kinase LI
MK subfamily","AGC protein kinase GEK subfamily","CMGC protein kinase HIPK subfamily","CMGC protein kinase Dyrk2 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Lipid modifying kinases","Receptor kinases","CAMK: Calcium/calmodulin-dependent protein
 kinases",Atypical,"STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","AGC: Containing PKA",PKG,"PKC families","CLK family","Cyclin-dependent kinase (CDK) family","Type II PIP kinase
s (1-phosphatidylinositol-5-phosphate 4-kinase family)","TK: Tyrosine kinase","Myosin Light Chain Kinase (MLCK) family",Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","TKL: Tyrosine kinase-li
ke","Death-associated kinase (DAPK) family","RIO family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family",
"PIM family","STE20 family","Phosphatidylinositol-4-phosphate 3-kinase family","DMPK family","Other protein kinases","1-phosphatidylinositol 4-kinase family","CDK7 subfamily","Non-receptor tyrosine ki
nases (nRTKs)","RAF family","RIO2 subfamily","FRAP subfamily","Other PIKK family kinases","Receptor tyrosine kinases (RTKs)","Dyrk1 subfamily","STE20 subfamily","LIM domain kinase (LISK) family","GEK 
subfamily","HIPK subfamily","Casein kinase 2 (CK2) family","Dyrk2 subfamily","IKK family","Janus kinase (JakA) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","LIMK subfamily"}

> <pathway_reactome>
{Disease,"Gene expression (Transcription)","Immune System","Signal Transduction","Programmed Cell Death","Metabolism of RNA",Metabolism,"Developmental Biology","Infectious disease","RNA Polymerase II 
Transcription","Cytokine Signaling in Immune system","Signaling by Rho GTPases","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinas
es",Apoptosis,"rRNA processing","Metabolism of lipids","Innate Immune System","Nervous system development","MAPK family signaling cascades","HIV Infection","Generic Transcription Pathway","Interferon 
Signaling","RHO GTPase Effectors","Signaling by FGFR in disease","Signaling by NTRKs","Caspase activation via extrinsic apoptotic signalling pathway","rRNA processing in the nucleus and cytosol","Phos
pholipid metabolism","Signaling by Interleukins","Signaling by Insulin receptor","Cytosolic sensors of pathogen-associated DNA","Axon guidance","MAPK1/MAPK3 signaling","Toll-like Receptor Cascades","H
IV Life Cycle","Transcriptional Regulation by TP53","Antiviral mechanism by IFN-stimulated genes","RHO GTPases activate PAKs","Signaling by FGFR1 in disease","Signaling by NTRK1 (TRKA)","Caspase activ
ation via Dependence Receptors in the absence of ligand","Major pathway of rRNA processing in the nucleolus and cytosol","PI Metabolism",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin rec
eptor signalling cascade","STING mediated induction of host immune responses","Interferon alpha/beta signaling","Semaphorin interactions","RAF/MAP kinase cascade","Toll Like Receptor 4 (TLR4) Cascade"
,"Late Phase of HIV Life Cycle","Regulation of TP53 Activity","ISG15 antiviral mechanism","FGFR1 mutant receptor activation","Signalling to ERKs","Synthesis of PIPs at the plasma membrane","Interleuki
n receptor SHC signaling","IRS-mediated signalling","IRF3-mediated induction of type I IFN","Regulation of IFNA signaling","Synthesis of PIPs at the Golgi membrane","Sema4D in semaphorin signaling","N
egative regulation of MAPK pathway","Synthesis of PIPs at the early endosome membrane","MyD88-independent TLR4 cascade","Transcription of the HIV genome","Regulation of TP53 Activity through Acetylati
on","Signaling by cytosolic FGFR1 fusion mutants","Prolonged ERK activation events","Regulation of TP53 Expression and Degradation","PI3K Cascade","Sema4D induced cell migration and growth-cone collap
se","Negative feedback regulation of MAPK pathway","Regulation of TP53 Activity through Phosphorylation","TRIF(TICAM1)-mediated TLR4 signaling","HIV Transcription Elongation","PI5P Regulates TP53 Acet
ylation","ARMS-mediated activation","Regulation of TP53 Degradation","IKK complex recruitment mediated by RIP1","Tat-mediated elongation of the HIV-1 transcript","Formation of HIV-1 elongation complex
 containing HIV-1 Tat"}

> <broad_targets>
{MTOR,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC}

> <broad_moa>
{"mTOR inhibitor","PI3K inhibitor"}

> <synonyms>
{I10,PI-103,PI103,371935-74-9,371935749,"3-(4-morpholinopyrido(3',2':4,5)furo(3,2-d)pyrimidin-2-yl)phenol","3(4morpholinopyrido(3',2':4,5)furo(3,2d)pyrimidin2yl)phenol","PI 103",UNII-YQX02F616F,UNIIYQ
X02F616F,"Phenol, 3-(4-(4-morpholinyl)pyrido(3',2':4,5)furo(3,2-d)pyrimidin-2-yl)-","Phenol, 3(4(4morpholinyl)pyrido(3',2':4,5)furo(3,2d)pyrimidin2yl)",PIK-103,PIK103,YQX02F616F,CHEBI:90524,3-(4-(4-Mo
rpholinyl)pyri,3(4(4Morpholinyl)pyri,T6143,"EMD 528100","Se S1038",528100}

> <pdid>
PD003364

> <targets>
{PI3K,MTOR,"DNA PK","PI3K CLASS I"}

> <classes>
{}

> <pubchem_cids>
{9884685}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 31  0  0  0  0            999 V2000
    3.8919   -5.2525    0.0000 O   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 O   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 S   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -3.8971   -5.2500    0.0000 C   0  0
   -2.5980   -6.0000    0.0000 C   0  0
   -1.2990   -5.2500    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
    0.0000   -3.0000    0.0000 S   0  0
    0.0000   -1.5000    0.0000 C   0  0
    6.4978   -0.7562    0.0000 N   0  0
    7.7969   -1.5062    0.0000 C   0  0
    9.0960   -0.7561    0.0000 C   0  0
    9.0959    0.7439    0.0000 O   0  0
    7.7969    1.4938    0.0000 C   0  0
    6.4979    0.7438    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  1  0
  6  7  2  3
  7  2  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 19 20  1  0
 20 21  1  0
 21  8  1  0
 21 12  2  0
  4 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 22  1  0
M  END
> <name>
UTKinase_V5

> <id>
28988

> <plate>
Kinase v5-3

> <well>
P21

> <supplier_cmpd_name>
KU-55933

> <ctcr_id>
4896

> <supplier_cmpd_id>
S1092

> <smiles>
O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5

> <pd_targets>
{PIK3CB,ATM,PRKDC,PIK3CA,MTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Lipid modifying kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Other PIKK f
amily kinases","FRAP subfamily"}

> <pathway_reactome>
{"Signal Transduction","Cell Cycle","Immune System",Disease,"Gene expression (Transcription)","Signaling by Receptor Tyrosine Kinases","Cell Cycle Checkpoints","Innate Immune System","Diseases of sign
al transduction by growth factor receptors and second messengers","RNA Polymerase II Transcription","Signaling by Insulin receptor","G1/S DNA Damage Checkpoints","Cytosolic sensors of pathogen-associa
ted DNA","Signaling by FGFR in disease","Generic Transcription Pathway","Insulin receptor signalling cascade","p53-Dependent G1/S DNA damage checkpoint","STING mediated induction of host immune respon
ses","Signaling by FGFR1 in disease","Transcriptional Regulation by TP53","IRS-mediated signalling","p53-Dependent G1 DNA Damage Response","IRF3-mediated induction of type I IFN","FGFR1 mutant recepto
r activation","Regulation of TP53 Activity","PI3K Cascade","Stabilization of p53","Signaling by cytosolic FGFR1 fusion mutants","Regulation of TP53 Expression and Degradation","Autodegradation of the 
E3 ubiquitin ligase COP1","Regulation of TP53 Degradation"}

> <broad_targets>
{ATM,PRKDC}

> <broad_moa>
{"ATM kinase inhibitor"}

> <synonyms>
{KU-55933,KU55933,587871-26-9,587871269,"ATM Kinase Inhibitor",2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one,2Morpholino6(thianthren1yl)4Hpyran4one,"KU 55933",2-Morpholin-4-yl-6-thianthren-1-ylpyran
-4-one,2Morpholin4yl6thianthren1ylpyran4one,2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one,"KU-55933 (ATM Kinase Inhibitor)","KU55933 (ATM Kinase Inhibitor)",UNII-O,UNIIO,T2685,S1092,"EMD 118500","Se 
S1092",3544,118500}

> <pdid>
PD003488

> <targets>
{ATM,"ATM Inhibitors"}

> <classes>
{}

> <pubchem_cids>
{5278396}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 21  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 C   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3070   -5.2494    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -6.4970    0.7465    0.0000 C   0  0
   -7.7969    1.4967    0.0000 C   0  0
   -9.0963    0.7473    0.0000 C   0  0
   -5.1993    2.9963    0.0000 C   0  0
   -3.9014    3.7484    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -1.3034    3.7525    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
  5 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 13 17  2  0
 17 18  1  0
 18 19  2  0
 19 11  1  0
 19 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
28989

> <plate>
Kinase v5-3

> <well>
B10

> <supplier_cmpd_name>
Honokiol

> <ctcr_id>
2818

> <supplier_cmpd_id>
S2310

> <smiles>
Oc1ccc(cc1CC=C)c2cc(CC=C)ccc2O

> <pd_targets>
{RORC,TGR,NA,PTGS2,PTGS1,FTL,POLB,GAA,CNR2,ALOX5,KMT2A,MEN1,MAPT,TIM10,GABRA1,GABRB2,GABRG2,GABRA2,CNR1,RXRA,GABRA3,GABRB1,GABRB3,GABRA5}

> <pathway_gtopdb>
{"Transcription factor",Enzyme,"Unclassified protein","Membrane receptor","Epigenetic regulator","Other cytosolic protein","Ion channel","Nuclear receptor",Hydrolase,Oxidoreductase,"Family A G protein
-coupled receptor",Reader,"Ligand-gated ion channel","Nuclear hormone receptor subfamily 1","Small molecule receptor (family A GPCR)",Bromodomain,"GABA-A receptor","Nuclear hormone receptor subfamily 
2","Nuclear hormone receptor subfamily 1 group F","Lipid-like ligand receptor (family A GPCR)","Nuclear hormone receptor subfamily 2 group B","Nuclear hormone receptor subfamily 1 group F member 3","C
annabinoid receptor","Nuclear hormone receptor subfamily 2 group B member 1"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Eicosanoid turnover","3.2.1.- Glycosidases","G protein-coupled receptors","1F. Retinoic acid-related orphans",Cyclooxygenase,"Cannabinoid receptors",Lip
oxygenases,"2B. Retinoid X receptors"}

> <pathway_reactome>
{"Gene expression (Transcription)",Metabolism,"Vesicle-mediated transport","DNA Repair",Disease,"Signal Transduction","Neuronal System","RNA Polymerase II Transcription","Metabolism of lipids","Membra
ne Trafficking","Base Excision Repair","Diseases of metabolism","Signaling by GPCR","Transmission across Chemical Synapses","Generic Transcription Pathway","Biosynthesis of specialized proresolving me
diators (SPMs)","Fatty acid metabolism","trans-Golgi Network Vesicle Budding","Resolution of Abasic Sites (AP sites)","Diseases of carbohydrate metabolism","GPCR downstream signalling","Neurotransmitt
er receptors and postsynaptic signal transmission","Metabolism of steroids","Transcriptional regulation by RUNX3","Biosynthesis of DPA-derived SPMs","Arachidonic acid metabolism","Golgi Associated Ves
icle Biogenesis","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","Glycogen storage diseases","G alpha (i) signalling events","Activation of NMDA receptors and postsynapt
ic events","Bile acid and bile salt metabolism","RUNX3 Regulates Immune Response and Cell Migration","Biosynthesis of DPAn-3 SPMs","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)","PCNA-Depend
ent Long Patch Base Excision Repair","Glycogen storage disease type II (GAA)","Post NMDA receptor activation events","Synthesis of bile acids and bile salts","Biosynthesis of DPAn-3-derived 13-series 
resolvins","Activation of AMPK downstream of NMDARs","Synthesis of bile acids and bile salts via 27-hydroxycholesterol"}

> <broad_targets>
{ALOX5,PTGS1,PTGS2}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{Honokiol,35354-74-6,35354746,"5,3'-Diallyl-2,4'-dihydroxybiphenyl","5,3'Diallyl2,4'dihydroxybiphenyl","NSC 293100","3,5'-Diallyl-4,2'-dihydroxybiphenyl","3,5'Diallyl4,2'dihydroxybiphenyl","Honokiol,(
S)",UNII-11513CCO0N,UNII11513CCO0N,"3',5-Diallylbiphenyl-2,4'-diol","3',5Diallylbiphenyl2,4'diol",C18H18O2,CPD000387107,CHEMBL16901,CHEBI:5759,3',5-diallyl-(1,5diallyl(1,1'-biph,1'biph,T3001,SAM001246
690}

> <pdid>
PD002976

> <targets>
{AKT,Akt,Autophagy,ERK,HCV}

> <classes>
{Anti-infection,Autophagy,MAPK/ERK Pathway,PI3K/Akt/mTOR,Stem Cell/Wnt}

> <pubchem_cids>
{72303}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  1  0            999 V2000
    4.3452   -0.0184    0.0000 N   0  0
    3.8794   -1.4442    0.0000 C   0  0
    4.8817   -2.5602    0.0000 O   0  0
    2.4133   -1.7530    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0  1  0  0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -2.6012   -3.0004    0.0000 C   0  0
   -3.9014   -3.7484    0.0000 C   0  0
   -5.1993   -2.9963    0.0000 N   0  0
   -5.1969   -1.4963    0.0000 C   0  0
   -3.8967   -0.7484    0.0000 C   0  0
   -6.5018   -3.7420    0.0000 C   0  0
   -6.5067   -5.2420    0.0000 O   0  0
   -7.7992   -2.9877    0.0000 C   0  0
   -9.1010   -3.7330    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.3114   -2.9665    0.0000 N   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.5536   -4.4230    0.0000 C   0  0
    1.9048   -5.7699    0.0000 C   0  0
    2.7504   -7.0088    0.0000 C   0  0
    4.2462   -6.8960    0.0000 C   0  0
    5.0948   -8.1338    0.0000 O   0  0
    6.5912   -8.0188    0.0000 C   0  0
    7.4412   -9.2547    0.0000 C   0  0
    8.9366   -9.1367    0.0000 C   0  0
    9.5820   -7.7827    0.0000 C   0  0
    8.7321   -6.5467    0.0000 C   0  0
    7.2368   -6.6647    0.0000 C   0  0
    4.8963   -5.5442    0.0000 C   0  0
    4.0507   -4.3052    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  6
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 10  1  0
 13 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  2  0
  9 20  1  0
 20  5  1  0
 20 21  1  0
 21 22  2  0
 22  4  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 26 34  1  0
 34 35  2  0
 35 23  1  0
M  END
> <name>
UTKinase_V5

> <id>
28991

> <plate>
Kinase v5-3

> <well>
B14

> <supplier_cmpd_name>
Zanubrutinib

> <ctcr_id>
15051

> <supplier_cmpd_id>
S8791

> <smiles>
NC(=O)c1c2NCC[C@@H](C3CCN(CC3)C(=O)C=C)n2nc1c4ccc(Oc5ccccc5)cc4

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{BGB-3111,HY-101474A,Zanubrutinib,Zanubrutinib}

> <pdid>
PD102989

> <targets>
{BTK,Btk}

> <classes>
{Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 34 38  0  0  0  0            999 V2000
   18.1924   -1.4596    0.0000 F   0  0
   16.8920   -0.7119    0.0000 C   0  0
   16.8892    0.7881    0.0000 C   0  0
   15.5888    1.5357    0.0000 C   0  0
   14.2910    0.7833    0.0000 C   0  0
   14.2939   -0.7167    0.0000 C   0  0
   15.5943   -1.4643    0.0000 C   0  0
   12.9888    1.5292    0.0000 N   0  0
   12.9836    3.0292    0.0000 C   0  0
   11.6820    3.7748    0.0000 C   0  0
   10.3856    3.0203    0.0000 C   0  0
   10.3907    1.5203    0.0000 C   0  0
    9.0920    0.7680    0.0000 C   0  0
    9.0945   -0.7320    0.0000 O   0  0
    7.7907    1.5158    0.0000 N   0  0
    6.4920    0.7636    0.0000 C   0  0
    5.1903    1.5091    0.0000 C   0  0
    3.8939    0.7546    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    2.6003   -1.4977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    5.2007   -1.4909    0.0000 C   0  0
    5.2059   -2.9909    0.0000 F   0  0
    6.4972   -0.7364    0.0000 C   0  0
   11.6923    0.7748    0.0000 C   0  0
   11.6975   -0.7252    0.0000 O   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  3
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 21  1  0
 29 25  2  0
 19 30  1  0
 30 31  1  0
 30 32  2  0
 32 16  1  0
 12 33  1  0
 33  8  1  0
 33 34  2  0
M  END
> <name>
UTKinase_V5

> <id>
28992

> <plate>
Kinase v5-3

> <well>
B16

> <supplier_cmpd_name>
BMS-2

> <ctcr_id>
462

> <supplier_cmpd_id>
SY-BMS-2

> <smiles>
Fc1ccc(cc1)N2C=CC=C(C(=O)Nc3ccc(Oc4ccnc5[nH]ccc45)c(F)c3)C2=O

> <pd_targets>
{FLT3,KIT,KDR,LCK,RIPK3,MET,RIPK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Tyrosine protein kinase PDGFR family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Src family",
"Tyrosine protein kinase Met family","TKL protein kinase RIPK family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","TKL: Tyrosine kinase-like","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Receptor interacting p
rotein kinase (RIPK) family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Src family","Type X RTKs: HGF (hepatocyte
 growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Immune System","Developmental Biology","Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Infe
ctious disease","Innate Immune System","Nervous system development","Signaling by Insulin receptor","Signaling by KIT in disease","Signaling by VEGF","HIV Infection","Toll-like Receptor Cascades","Axo
n guidance","Insulin receptor signalling cascade","Drug resistance of KIT mutants","VEGFA-VEGFR2 Pathway","Host Interactions of HIV factors","Toll Like Receptor 4 (TLR4) Cascade","Semaphorin interacti
ons","IRS-mediated signalling","Dasatinib-resistant KIT mutants","VEGFR2 mediated cell proliferation","The role of Nef in HIV-1 replication and disease pathogenesis","MyD88-independent TLR4 cascade","
Sema4D in semaphorin signaling","PI3K Cascade","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","TRIF(TICAM1)-mediated TLR4 signaling","Sema4D mediated 
inhibition of cell attachment and migration","Nef Mediated CD4 Down-regulation","IKK complex recruitment mediated by RIP1"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MS,BMS-2,BMS2,888719-03-7,888719037,1FN,3ce3,"2-pyridone analogue, 2","2pyridone analogue, 2","JMC521251 Compound 1",CHEMBL509101,SCHEMBL4817260,BDBM24440,DTXSID50610618,SYN1022,C25H16F2N4O3,BCPP0003
29,MFCD16619360,ZINC20148998,BCP9000423,DB06896,NCGC00345824-01,NCGC0034582401,NCGC00345824-02,NCGC0034582402,FT-0729495,FT0729495,7,SY-BMS-2}

> <pdid>
PD005804

> <targets>
{Met/Flt-3/VEGFR2,MET}

> <classes>
{}

> <pubchem_cids>
{21081761}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 38  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 N   0  0
   -3.8990   -0.7525    0.0000 C   0  0
   -3.9046    0.7483    0.0000 O   0  0
   -5.2066    1.4948    0.0000 C   0  0
   -6.5019    0.7382    0.0000 C   0  0
   -7.8048    1.4816    0.0000 C   0  0
   -7.8124    2.9815    0.0000 C   0  0
   -6.5172    3.7381    0.0000 C   0  0
   -5.2143    2.9948    0.0000 C   0  0
   -3.9192    3.7514    0.0000 C   0  0
   -9.1022    0.7272    0.0000 C   0  0
   -9.0972   -0.7728    0.0000 O   0  0
  -10.4047    1.4729    0.0000 N   0  0
  -11.7022    0.7185    0.0000 C   0  0
  -13.0051    1.4619    0.0000 C   0  0
  -14.3003    0.7053    0.0000 C   0  0
  -14.2927   -0.7947    0.0000 C   0  0
  -12.9899   -1.5381    0.0000 C   0  0
  -11.6947   -0.7815    0.0000 C   0  0
  -12.9823   -3.0389    0.0000 C   0  0
  -14.2771   -3.7963    0.0000 F   0  0
  -11.6793   -3.7819    0.0000 F   0  0
  -12.9740   -4.5389    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  3  1  0
  7  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14  9  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 16  1  0
 21 22  1  0
 18 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 26  1  0
 30 32  1  0
 32 33  1  0
 32 34  1  0
 32 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
28993

> <plate>
Kinase v5-3

> <well>
B18

> <supplier_cmpd_name>
AMG-Tie2

> <ctcr_id>
5891

> <supplier_cmpd_id>
SY-AMG-Tie2

> <smiles>
CNc1nccc(n1)c2cccnc2Oc3cc(ccc3C)C(=O)Nc4cccc(c4)C(F)(F)F

> <pd_targets>
{YES1,KDR,TEK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase Src family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Tie family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Non-receptor tyrosine kinases (nRTKs)","Receptor tyrosine kinases (RTKs)","Src family","Type IV RTKs: VEGF (vascular endothel
ial growth factor) receptor family","Type XII RTKs: TIE family of angiopoietin receptors"}

> <pathway_reactome>
{Disease,"Signal Transduction","Infectious disease","Signaling by Receptor Tyrosine Kinases","MAPK family signaling cascades","Leishmania infection","Signaling by VEGF","MAPK1/MAPK3 signaling","Leishm
ania parasite growth and survival","VEGFA-VEGFR2 Pathway","RAF/MAP kinase cascade","Anti-inflammatory response favouring Leishmania parasite infection","VEGFR2 mediated cell proliferation","FCGR3A-med
iated IL10 synthesis"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MGTIE2,AMG-Tie2-1,AMGTie21,870223-96-4,870223964,AMG-Tie2,AMGTie2,PubChem22413,"pyridinyl pyrimidine 15","pyridylpyrimidine ether 4","AMG-Tie 2-1","AMGTie 21",AMG-Tie2-1/,AMGTie21/,CHEMBL218632,SCHEM
BL1264498,BDBM14948,DTXSID20582974,SYN1008,BCPP000406,HMS3244C13,HMS3244C14,HMS3244D13,BCP01978,ABP00,SY-AMG-Tie2}

> <pdid>
PD118329

> <targets>
{"Dual inhibitor of Tie2 and VEGFR2",TK}

> <classes>
{}

> <pubchem_cids>
{16108977}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    2.6015   -1.5060    0.0000 C   0  0
    2.5973   -3.0060    0.0000 C   0  0
    3.8942   -3.7597    0.0000 C   0  0
    3.8899   -5.2597    0.0000 C   0  0
    5.1868   -6.0134    0.0000 I   0  0
    2.5887   -6.0060    0.0000 C   0  0
    1.2918   -5.2523    0.0000 C   0  0
    1.2961   -3.7523    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -0.0128   -6.0039    0.0000 F   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -2.6160   -7.4949    0.0000 F   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -5.2089   -5.9859    0.0000 F   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -2.5984   -1.4941    0.0000 C   0  0
   -1.2981   -0.7463    0.0000 O   0  0
   -3.8966   -0.7411    0.0000 N   0  0
   -3.8946    0.7597    0.0000 O   0  0
   -5.1928    1.5127    0.0000 C   0  0
   -5.1908    3.0135    0.0000 C   0  0
   -5.9366    4.2238    0.0000 C   0  0
   -4.4366    4.2186    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  4  6  2  0
  6  7  1  0
  7  8  2  0
  8  2  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 13 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18 10  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 24  1  0
M  END
> <name>
UTKinase_V5

> <id>
28994

> <plate>
Kinase v5-3

> <well>
B20

> <supplier_cmpd_name>
PD 198306

> <ctcr_id>
3170

> <supplier_cmpd_id>
2605

> <smiles>
Cc1cc(I)ccc1Nc2c(F)c(F)c(F)cc2C(=O)NOCC3CC3

> <pd_targets>
{RORC,KMT2A,MEN1}

> <pathway_gtopdb>
{"Transcription factor","Epigenetic regulator","Nuclear receptor",Reader,"Nuclear hormone receptor subfamily 1",Bromodomain,"Nuclear hormone receptor subfamily 1 group F","Nuclear hormone receptor sub
family 1 group F member 3"}

> <pathway_chembl>
{Receptors,"Nuclear hormone receptors","1F. Retinoic acid-related orphans"}

> <pathway_reactome>
{"Gene expression (Transcription)","RNA Polymerase II Transcription","Generic Transcription Pathway","Transcriptional regulation by RUNX3","RUNX3 Regulates Immune Response and Cell Migration"}

> <broad_targets>
{MAP2K1,MAP2K2}

> <broad_moa>
{"MAP kinase inhibitor","MEK inhibitor"}

> <synonyms>
{HMS3413J17,HMS3677J17,ZINC3964489,"PD 198306",212631-61-3,212631613,PD-198306,PD198306,UNII-WQ5121ZGT3,UNIIWQ5121ZGT3,WQ5121ZGT3,SCHEMBL1801637,CHEMBL1474985,CHEBI:93541,DTXSID70433306,HMS3229H15,HMS
3269F09,AKOS024457191,NCGC00167793-01,NCGC0016779301,NCGC00167793-02,NCGC0016779302,B7124,J-013958,J013958,BRD-K88677950-,BRDK88677950,2605,"EMD 444965",444965}

> <pdid>
PD015686

> <targets>
{MEK1/2,MEK,"MEK1/2 Inhibitor II"}

> <classes>
{}

> <pubchem_cids>
{9956637}

$$$$
UTKinase_V5
  SciTegic11012413002D

 42 45  0  0  0  0            999 V2000
   -6.4810   -3.6830    0.0000 C   0  0
   -6.4959   -5.1829    0.0000 C   0  0
   -5.2041   -5.9470    0.0000 N   0  0
   -5.2168   -7.4469    0.0000 C   0  0
   -3.9242   -8.2079    0.0000 C   0  0
   -2.6188   -7.4691    0.0000 N   0  0
   -1.3239   -8.2279    0.0000 C   0  0
   -0.0189   -7.4867    0.0000 C   0  0
    1.2764   -8.2433    0.0000 C   0  0
    2.5792   -7.4998    0.0000 C   0  0
    2.5868   -5.9998    0.0000 C   0  0
    3.8888   -5.2533    0.0000 N   0  0
    3.8943   -3.7525    0.0000 C   0  0
    5.1945   -3.0045    0.0000 N   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    3.9015    0.7475    0.0000 F   0  0
    2.5987   -1.5004    0.0000 C   0  0
    2.5965   -3.0004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 F   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.1065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.1904   -2.6376    0.0000 C   0  0
   -4.6580   -2.9476    0.0000 C   0  0
   -2.1885   -3.7539    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.2915   -5.2433    0.0000 N   0  0
   -0.0113   -5.9867    0.0000 C   0  0
   -2.6061   -5.9691    0.0000 C   0  0
   -3.8987   -5.2081    0.0000 C   0  0
    8.9969   -1.1213    0.0000 C   0  0
    8.9969   -2.6213    0.0000 S   0  0
    7.6976   -3.3708    0.0000 O   0  0
   10.2962   -3.3708    0.0000 O   0  0
    8.9969   -4.1213    0.0000 O   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 19 13  1  0
 18 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  1  0
 29 30  1  0
 29 31  1  0
 28 32  1  0
 32 24  1  0
 32 33  2  0
 33 20  1  0
 11 34  1  0
 34 35  2  0
 35  8  1  0
  6 36  1  0
 36 37  1  0
 37  3  1  0
 38 39  1  0
 39 40  2  0
 39 41  2  0
 39 42  1  0
M  END
> <name>
UTKinase_V5

> <id>
28997

> <plate>
Kinase v5-3

> <well>
D12

> <supplier_cmpd_name>
Abemaciclib

> <ctcr_id>
3149

> <supplier_cmpd_id>
S5716

> <smiles>
CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)c4cc(F)c5nc(C)n(C(C)C)c5c4)nc2)CC1.CS(=O)(=O)O

> <pd_targets>
{CCNA2,CDK2,CCND3,CDK4,CDK6,CDK7,CDK1,GSC2,CCNT1,CDK9,CCNE1,REP,CCND1,KCNH2,CCNB1,CDK5,CDK5R1,CCNH,MNAT1}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,Transferase,"Voltage-gated ion channel","Protein Kinase","Potassium channels","CMGC protein kinase group","Voltage-gated potassium channel","CMGC protein kinase CDK family
","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK7 subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,"Other protein targets","Ion channels","Kinases (EC 2.7.x.x)","Anti-infective targets","Voltage-gated ion channels","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Viral protein targets","Po
tassium channels","Cyclin-dependent kinase (CDK) family","Coronavirus (CoV) proteins","Voltage-gated potassium channels","CDK7 subfamily","CDK1 subfamily","CDK4 subfamily","CDK9 subfamily"}

> <pathway_reactome>
{Disease,"Cell Cycle","Muscle contraction","Infectious disease",Mitotic,"Cardiac conduction","HIV Infection","Regulation of mitotic cell cycle","Mitotic G1 phase and G1/S transition","SARS-CoV Infecti
ons","Phase 3 - rapid repolarisation","HIV Life Cycle","APC/C-mediated degradation of cell cycle proteins","G1 Phase","SARS-CoV-2 Infection","Late Phase of HIV Life Cycle","Activation of APC/C and APC
/C:Cdc20 mediated degradation of mitotic proteins","Cyclin D associated events in G1","SARS-CoV-2 Genome Replication and Transcription","Transcription of the HIV genome","APC/C:Cdc20 mediated degradat
ion of mitotic proteins","Replication of the SARS-CoV-2 genome","HIV Transcription Elongation","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint"
,"Tat-mediated elongation of the HIV-1 transcript","Cdc20:Phospho-APC/C mediated degradation of Cyclin A","Formation of HIV-1 elongation complex containing HIV-1 Tat"}

> <broad_targets>
{CDK4,CDK6}

> <broad_moa>
{"CDK inhibitor"}

> <synonyms>
{1231930-82-7,1231930827,"Abemaciclib mesylate",LY2835219,"LY2835219 Mesylate","Abemaciclib methanesulfonate",UNII-KKT462Q807,UNIIKKT462Q807,"Abemaciclib (methanesulfonate)",KKT462Q807,"1231930-82-7 (
mesylate)","1231930827 (mesylate)","Abemaciclib (ly2835219)",bemaciclib,"LY-2835219 methanesulfonate","LY2835219 methanesulfonate",T3111,T2381,S7158,"abemaciclib mesylate",Abemaciclib}

> <pdid>
PD038907

> <targets>
{CDK4/6,CDK}

> <classes>
{Cell Cycle,Cell Cycle/DNA Damage}

> <pubchem_cids>
{71576678}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  1  0            999 V2000
    9.2971    4.6579    0.0000 C   0  0
    8.0391    3.8409    0.0000 O   0  0
    8.1168    2.3421    0.0000 C   0  0
    9.4532    1.6608    0.0000 O   0  0
    6.8582    1.5246    0.0000 C   0  0
    6.9359    0.0258    0.0000 C   0  0  2  0  0  0
    5.5999    0.7078    0.0000 O   0  0
    8.2730   -0.6559    0.0000 C   0  0
    9.5324    0.1605    0.0000 C   0  0
   10.8695   -0.5212    0.0000 C   0  0
   12.1289    0.2951    0.0000 C   0  0
   13.3872    1.1116    0.0000 C   0  0
   12.0512    1.7931    0.0000 C   0  0
   13.4653   -0.3862    0.0000 O   0  0
    5.6765   -0.7905    0.0000 C   0  0
    5.7542   -2.2885    0.0000 O   0  0
    4.3394   -0.1088    0.0000 O   0  0
    3.0821   -0.9238    0.0000 C   0  0  1  0  0  0
    1.6852   -0.3846    0.0000 C   0  0  1  0  0  0
    1.3514    1.0778    0.0000 C   0  0
    2.5913    1.9239    0.0000 C   0  0
    2.4792    3.4197    0.0000 C   0  0
    3.5155    4.5031    0.0000 O   0  0
    2.8046    5.8240    0.0000 C   0  0
    1.3287    5.5562    0.0000 O   0  0
    1.1278    4.0705    0.0000 C   0  0
   -0.1116    3.2255    0.0000 C   0  0
    0.0000    1.7286    0.0000 C   0  0
   -1.3515    1.0777    0.0000 C   0  0
   -1.6852   -0.3847    0.0000 C   0  0
   -0.7500   -1.5574    0.0000 N   0  0
   -1.2172   -2.9891    0.0000 C   0  0
   -0.0039   -3.8711    0.0000 C   0  0
    1.2099   -2.9897    0.0000 C   0  0
    0.7500   -1.5574    0.0000 C   0  0  2  0  0  0
    1.5613   -2.8152    0.0000 C   0  0
    3.0088   -2.4220    0.0000 C   0  0
    4.1745   -3.3632    0.0000 O   0  0
    3.9429   -4.8452    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  1
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 11 14  1  0
  6 15  1  0
 15 16  2  0
 15 17  1  0
 18 17  1  6
 18 19  1  0
 19 20  1  6
 20 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 22  2  0
 26 27  1  0
 27 28  2  0
 28 20  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 35 34  1  1
 35 19  1  0
 35 31  1  0
 35 36  1  0
 36 37  2  3
 37 18  1  0
 37 38  1  0
 38 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28998

> <plate>
Kinase v5-3

> <well>
D14

> <supplier_cmpd_name>
Homoharringtonine

> <ctcr_id>
4036

> <supplier_cmpd_id>
S9015

> <smiles>
COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN5CCC[C@]25C=C1OC

> <pd_targets>
{RPL3,HTT,RORC,LEF,CYP3A4}

> <pathway_gtopdb>
{"Unclassified protein","Transcription factor",Enzyme,"Nuclear receptor",Protease,"Cytochrome P450","Nuclear hormone receptor subfamily 1","Metallo protease","Cytochrome P450 family 3","Nuclear hormon
e receptor subfamily 1 group F","Metallo protease MAE clan","Cytochrome P450 family 3A","Nuclear hormone receptor subfamily 1 group F member 3","Metallo protease M34 family","Cytochrome P450 3A4"}

> <pathway_chembl>
{Receptors,Enzymes,"Nuclear hormone receptors","Cytochrome P450","1F. Retinoic acid-related orphans","CYP3 family"}

> <pathway_reactome>
{"Developmental Biology","Nervous system development","Axon guidance","Signaling by ROBO receptors","Regulation of expression of SLITs and ROBOs","Gene expression (Transcription)",Disease,Metabolism,"
RNA Polymerase II Transcription","Infectious disease","Metabolism of lipids","Generic Transcription Pathway","Uptake and actions of bacterial toxins","Biosynthesis of specialized proresolving mediator
s (SPMs)","Transcriptional Regulation by MECP2","Transcriptional regulation by RUNX3","Uptake and function of anthrax toxins","Biosynthesis of DHA-derived SPMs","Regulation of MECP2 expression and act
ivity","RUNX3 Regulates Immune Response and Cell Migration","Biosynthesis of maresins","Biosynthesis of maresin-like SPMs"}

> <broad_targets>
{RPL3}

> <broad_moa>
{"protein synthesis inhibitor"}

> <synonyms>
{homoharringtonine,"Omacetaxine mepesuccinate",Synribo,26833-87-4,26833874,Ceflatonin,Myelostat,CGX-635,CGX635,(-)-homoharringtonine,()homoharringtonine,Omapro,NSC-141633,NSC141633,UNII-6FG8041S5B,UNI
I6FG8041S5B,CHEBI:71019,C29H39NO9,"(2'R,3S,4S,5R)-(-)-homoharringtonine","(2'R,3S,4S,5R)()homoharringtonine",6FG8041S5B,NSC,T3380,758253,1416,SAM001246822,Homoharringtonine,CPD000469230}

> <pdid>
PD003333

> <targets>
{STAT3,STAT}

> <classes>
{Protein synthesis inhibitor,JAK/STAT Signaling,Stem Cell/Wnt}

> <pubchem_cids>
{285033}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 43  0  0  0  0            999 V2000
    3.9015    0.7475    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 N   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -5.1984    1.4977    0.0000 N   0  0
   -6.4971    0.7454    0.0000 C   0  0
   -7.7984    1.4932    0.0000 C   0  0
   -9.0971    0.7409    0.0000 N   0  0
  -10.3988    1.4863    0.0000 C   0  0
  -11.6952    0.7318    0.0000 C   0  0
  -11.6900   -0.7682    0.0000 O   0  0
  -10.3884   -1.5137    0.0000 C   0  0
   -9.0920   -0.7592    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 N   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    3.8888   -5.2533    0.0000 C   0  0
    5.1854   -6.0076    0.0000 O   0  0
    2.5868   -5.9998    0.0000 N   0  0
    2.5814   -7.5006    0.0000 C   0  0
    1.2811   -8.2486    0.0000 C   0  0
    1.2787   -9.7486    0.0000 C   0  0
    2.5766  -10.5007    0.0000 C   0  0
    3.8768   -9.7528    0.0000 C   0  0
    3.8792   -8.2528    0.0000 C   0  0
    5.1753  -10.5053    0.0000 C   0  0
    5.1739  -12.0053    0.0000 F   0  0
    6.4754   -9.7570    0.0000 F   0  0
    6.4735  -11.2568    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 17  1  0
 13 23  1  0
 23 24  2  0
 24 25  1  0
 25 11  1  0
 25 26  2  0
 26  8  1  0
  5 27  1  0
 27 28  2  0
 27 29  1  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 30  1  0
 34 36  1  0
 36 37  1  0
 36 38  1  0
 36 39  1  0
M  END
> <name>
UTKinase_V5

> <id>
28999

> <plate>
Kinase v5-3

> <well>
D16

> <supplier_cmpd_name>
AMG47a

> <ctcr_id>
740

> <supplier_cmpd_id>
SY-AMG47a

> <smiles>
Cc1ccc(cc1c2ccc3nc(NCCN4CCOCC4)ncc3c2)C(=O)Nc5cccc(c5)C(F)(F)F

> <pd_targets>
{KDR,JAK3,MAPK9,SRC,LCK,TYK2,BTK,MAPK8,MAPK10,SYK,MAPK14}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase JakA family","CMGC protein kinase MAPK family","Ty
rosine protein kinase Src family","Tyrosine protein kinase Tec family","Tyrosine protein kinase Syk family","CMGC protein kinase JNK subfamily","CMGC protein kinase p38 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Catalytic receptors","Kinases (EC 2.7.x.x)","Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","TK: Tyrosine kinase","Mitogen-activated protein kinases (MAP kinases
)","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","JNK subfamily","p38 subfamily","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Janus kinase (J
akA) family","Src family","Tec family","Syk family"}

> <pathway_reactome>
{"Signal Transduction","Immune System",Disease,"Signaling by Receptor Tyrosine Kinases","Cytokine Signaling in Immune system","Innate Immune System","Infectious disease","Signaling by VEGF","Signaling
 by Interleukins","Toll-like Receptor Cascades","Signaling by NTRKs","HIV Infection","Interferon Signaling","Leishmania infection","VEGFA-VEGFR2 Pathway","Interleukin-2 family signaling","Toll Like Re
ceptor 5 (TLR5) Cascade","Signaling by NTRK1 (TRKA)","Host Interactions of HIV factors","Interferon alpha/beta signaling","Parasite infection","Leishmania parasite growth and survival","VEGFR2 mediate
d cell proliferation","Interleukin-15 signaling","MyD88 cascade initiated on plasma membrane","Signalling to ERKs","The role of Nef in HIV-1 replication and disease pathogenesis","Regulation of IFNA s
ignaling","Leishmania phagocytosis","Anti-inflammatory response favouring Leishmania parasite infection","MAP kinase activation","Signalling to RAS","Nef-mediates down modulation of cell surface recep
tors by recruiting them to clathrin adapters","FCGR3A-mediated phagocytosis","FCGR3A-mediated IL10 synthesis","MAPK targets/ Nuclear events mediated by MAP kinases","p38MAPK events","Nef Mediated CD4 
Down-regulation","Activation of the AP-1 family of transcription factors"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MG47,AMG-47a,AMG47a,882663-88-9,882663889,CHEMBL215943,AMG-47,AMG47,C29H28F3N5O2,PubChem22409,AMG-47a/,AMG47a/,SCHEMBL5490450,AOB6159,DTXSID40582077,EX-A508,EXA508,SYN1007,BCPP000408,HMS3244I05,HMS32
44I06,HMS3244J05,BCP01962,ABP000504,BDBM50194668,MFCD09970318,s2213,ZINC34802946,AKO,SY-AMG47a}

> <pdid>
PD080550

> <targets>
{Lck}

> <classes>
{}

> <pubchem_cids>
{16086114}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    5.1996   -1.4928    0.0000 C   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 C   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.4133   -1.7530    0.0000 N   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -2.5496   -4.4224    0.0000 N   0  0
   -1.7973   -5.7210    0.0000 C   0  0
   -0.2973   -5.7184    0.0000 O   0  0
   -2.5450   -7.0224    0.0000 C   0  0
   -1.7950   -8.3214    0.0000 C   0  0
   -2.5450   -9.6205    0.0000 C   0  0
   -4.0450   -9.6206    0.0000 C   0  0
   -4.7951   -8.3216    0.0000 N   0  0
   -4.0451   -7.0225    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 N   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000    3.0008    0.0000 C   0  0
    1.2985    3.7517    0.0000 F   0  0
   -1.2993    3.7504    0.0000 F   0  0
   -0.0007    4.5008    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 11 21  2  0
 21 22  1  0
 22  5  1  0
 22  9  1  0
  7 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
29000

> <plate>
Kinase v5-3

> <well>
D18

> <supplier_cmpd_name>
S-99

> <ctcr_id>
4588

> <supplier_cmpd_id>
SY-S-99

> <smiles>
CC(C)Nc1cc(cc2nc(NC(=O)c3cccnc3)nn12)C(F)(F)F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{9,S-99,S99,1124381-69-6,1124381696,C16H15F3N6O,SCHEMBL2812561,CHEMBL3183131,SYN1119,BCP29577,LT0083,ZINC90408699,NCGC00345841-01,NCGC0034584101,NCGC00345841-02,NCGC0034584102,AS-16261,AS16261,"S 99; 
S99",X5890,SY-S-99}

> <pdid>

> <targets>
{ASK}

> <classes>
{}

> <pubchem_cids>
{59437537}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 20  0  0  0  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 O   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 O   0  0
   -5.1984   -1.4978    0.0000 C   0  0
   -6.4971   -0.7455    0.0000 N   0  0
   -7.7984   -1.4932    0.0000 N   0  0
   -9.0971   -0.7410    0.0000 C   0  0
  -10.3977   -1.4883    0.0000 S   0  0
   -9.0945    0.7590    0.0000 N   0  0
    3.7998   -1.1250    0.0000 Cl  0  0
    5.0990   -0.3754    0.0000 Cu  0  0
    6.3983   -1.1250    0.0000 Cl  0  0
  1  2  2  3
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  1  1  0
  5  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  2  3
 10 11  1  0
 11  4  1  0
  9 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 18 19  1  0
 19 20  1  0
M  END
> <name>
UTKinase_V5

> <id>
29001

> <plate>
Kinase v5-3

> <well>
D20

> <supplier_cmpd_name>
FPA 124

> <ctcr_id>
3674

> <supplier_cmpd_id>
2926

> <smiles>
C1=CC=C2C(=C1)C(=O)C(=CO2)C=NNC(=S)N.Cl[Cu]Cl

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"AKT inhibitor"}

> <synonyms>
{"FPA 124",902779-59-3,902779593,2926}

> <pdid>
PD153752

> <targets>
{Akt/PKB,PKB}

> <classes>
{}

> <pubchem_cids>
{102586612}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 N   0  0
    2.5981    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 N   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
   -2.5987   -1.5004    0.0000 C   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -6.4924   -3.7566    0.0000 Cl  0  0
   -3.9015    0.7475    0.0000 Cl  0  0
    3.8963    3.7531    0.0000 N   0  0
    3.8941    5.2539    0.0000 C   0  0
    5.1905    6.0085    0.0000 C   0  0
    5.1853    7.5085    0.0000 C   0  0
    3.8837    8.2540    0.0000 C   0  0
    2.5873    7.4995    0.0000 C   0  0
    2.5925    5.9995    0.0000 C   0  0
    3.8785    9.7548    0.0000 N   0  0
    5.1737   10.5114    0.0000 C   0  0
    5.1661   12.0114    0.0000 C   0  0
    3.8633   12.7548    0.0000 N   0  0
    2.5681   11.9983    0.0000 C   0  0
    2.5757   10.4983    0.0000 C   0  0
    6.4818    8.2630    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  3
  5  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  2  3
  9  4  1  0
  9 10  1  0
 10 11  2  3
 11 12  1  0
 12  3  1  0
 12 13  2  0
 11 14  1  0
 14 15  2  3
 15 16  1  0
 16 17  2  3
 17 18  1  0
 18 19  2  3
 19 14  1  0
 17 20  1  0
 15 21  1  0
  6 22  1  0
 22 23  1  0
 23 24  2  3
 24 25  1  0
 25 26  2  3
 26 27  1  0
 27 28  2  3
 28 23  1  0
 26 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 29  1  0
 25 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
29002

> <plate>
Kinase v5-3

> <well>
D22

> <supplier_cmpd_name>
FRAX 486

> <ctcr_id>
12967

> <supplier_cmpd_id>
5190

> <smiles>
CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)Cl)Cl)NC4=CC(=C(C=C4)N5CCNCC5)F

> <pd_targets>
{PAK2,PAK3,PAK4,PAK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","STE protein kinase STE20 family","STE protein kinase PAKA subfamily","STE protein kinase PAKB subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","STE20 family","PAKA subfamily","PAKB subfamily"}

> <pathway_reactome>
{Disease,"Developmental Biology","Infectious disease","Nervous system development","HIV Infection","Axon guidance","Host Interactions of HIV factors","EPH-Ephrin signaling","Signaling by ROBO receptor
s","The role of Nef in HIV-1 replication and disease pathogenesis","Ephrin signaling","Activation of RAC1","EPHB-mediated forward signaling","Nef and signal transduction"}

> <broad_targets>
{PAK1,PAK2,PAK3,PAK4}

> <broad_moa>
{"serine/threonine kinase inhibitor"}

> <synonyms>
{FRAX486,1232030-35-1,1232030351,FRAX-486,"FRAX 486",CHEMBL3609326,C25H23Cl2FN6O,GTPL8938,SCHEMBL10192789,AOB6119,BCP13764,EX-A2201,EXA2201,3683AH,BDBM50112355,HY-15542B,HY15542B,s7807,ZINC95930185,AK
OS024458531,CCG-269796,CCG269796,CS-3548,CS3548,SB17179,NCGC00379255-06,NCGC0037925506,AC-33021,AC33021,AK547126,DS-,DS,T6840}

> <pdid>
PD012562

> <targets>
{PAK,"PAK1£» PAK2 £» PAK3 £»PAK4"}

> <classes>
{"Cell cycle/Check point"}

> <pubchem_cids>
{68060125}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 27  0  0  1  0            999 V2000
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 C   0  0
    1.3039   -3.7494    0.0000 C   0  0  2  0  0  0
    2.6039   -2.9994    0.0000 C   0  0
    3.9032   -3.7490    0.0000 O   0  0
    2.6039   -1.4994    0.0000 O   0  0
    1.3070   -5.2502    0.0000 O   0  0
    2.6078   -5.9988    0.0000 C   0  0
    3.9056   -5.2465    0.0000 O   0  0
    2.6109   -7.4996    0.0000 C   0  0
    3.9117   -8.2481    0.0000 C   0  0
    3.9148   -9.7490    0.0000 C   0  0
    5.2139  -10.4990    0.0000 C   0  0
    5.2139  -11.9990    0.0000 C   0  0
    3.9149  -12.7491    0.0000 C   0  0
    2.6158  -11.9991    0.0000 C   0  0
    2.6158  -10.4991    0.0000 C   0  0
    3.9149  -14.2491    0.0000 O   0  0
    6.5130  -12.7490    0.0000 O   0  0
   -2.5981    1.5000    0.0000 O   0  0
    0.0000    3.0000    0.0000 O   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  1  1  0
  6  7  1  0
  8  7  1  6
  8  9  1  0
  9 10  2  0
  9 11  1  0
  8 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 20 23  1  0
 19 24  1  0
  4 25  1  0
  3 26  1  0
M  END
> <name>
UTKinase_V5

> <id>
29003

> <plate>
Kinase v5-3

> <well>
F10

> <supplier_cmpd_name>
Rosmarinic acid

> <ctcr_id>
11719

> <supplier_cmpd_id>
S3612

> <smiles>
c1cc(c(cc1C[C@H](C(=O)O)OC(=O)/C=C/c1cc(c(cc1)O)O)O)O

> <pd_targets>
{RECQL,HSD17B10,KDM4E,FFP,ALD,HPGD,GAA,MEX-5,POLB,TGR,POS-1,MAPT,AMPC,IMPA1,TDP1,MCL1,"REVERSE TRANSCRIPTASE",BLM,HSD17B2,SRC,MMP1,TTR,POL,LCK,GLMU,THRB,APP,REP,AKR1B1,USP2,NS1,MMP2,APEX1,PKM,FYN,JUN}

> <pathway_gtopdb>
{Enzyme,"Epigenetic regulator","Transcription factor","Other cytosolic protein","Secreted protein","Membrane receptor","Unclassified protein",Oxidoreductase,Eraser,Transferase,Hydrolase,Protease,Kinas
e,"Nuclear receptor","Lysine demethylase","Cysteine protease","Protein Kinase","Metallo protease","Nuclear hormone receptor subfamily 1","Jumonji domain-containing","Cysteine protease CA clan","TK pro
tein kinase group","Metallo protease MAM clan","Nuclear hormone receptor subfamily 1 group A","Cysteine protease C1A family","Tyrosine protein kinase Src family","Metallo protease M10A subfamily","Nuc
lear hormone receptor subfamily 1 group A member 2","Cysteine protease C19 family","Tyrosine protein kinase SrcA"}

> <pathway_chembl>
{Enzymes,"Other protein targets",Receptors,"Chromatin modifying enzymes","Eicosanoid turnover","3.2.1.- Glycosidases","Inositol phosphate turnover","B-cell lymphoma 2 (Bcl-2) protein family","1.-.-.- 
Oxidoreductases","Catalytic receptors","Peptidases and proteinases",Transthyretin,"Nuclear hormone receptors","Anti-infective targets","2.7.1.40 Pyruvate kinases","1.14.11.- Histone demethylases","Pro
staglandin synthases","Inositol monophosphatase","Receptor kinases","MA: Metallo (M) Peptidases","1A. Thyroid hormone receptors","Viral protein targets","CA: Cysteine (C) Peptidases","TK: Tyrosine kin
ase","M10: Matrix metallopeptidase","Coronavirus (CoV) proteins","C19: Ubiquitin-specific protease","Non-receptor tyrosine kinases (nRTKs)","Src family"}

> <pathway_reactome>
{Metabolism,Disease,"DNA Repair","Neuronal System","Immune System","Signal Transduction","Metabolism of proteins","Gene expression (Transcription)","Developmental Biology","Metabolism of amino acids a
nd derivatives","Metabolism of lipids","Diseases of metabolism","Base Excision Repair","Transmission across Chemical Synapses","Inositol phosphate metabolism","DNA Double-Strand Break Repair","Cytokin
e Signaling in Immune system","Signaling by Receptor Tyrosine Kinases","Signaling by GPCR","Infectious disease","Post-translational protein modification","Innate Immune System","RNA Polymerase II Tran
scription","Nervous system development","Metabolism of carbohydrates","Branched-chain amino acid catabolism","Biosynthesis of specialized proresolving mediators (SPMs)","Diseases of carbohydrate metab
olism","Resolution of Abasic Sites (AP sites)","Neurotransmitter receptors and postsynaptic signal transmission","Synthesis of IP2",IP,"and Ins in the cytosol","Nonhomologous End-Joining (NHEJ)","Sign
aling by Interleukins","Homology Directed Repair","Metabolism of steroids","Signaling by NTRKs","GPCR downstream signalling","HIV Infection",SUMOylation,"Toll-like Receptor Cascades","SARS-CoV Infecti
ons","Generic Transcription Pathway","Axon guidance","Glucose metabolism","Biosynthesis of DHA-derived SPMs","Glycogen storage diseases","Resolution of AP sites via the multiple-nucleotide patch repla
cement pathway","Activation of NMDA receptors and postsynaptic events","Interleukin-4 and Interleukin-13 signaling","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Metab
olism of steroid hormones","Signaling by NTRK1 (TRKA)","G alpha (i) signalling events","Host Interactions of HIV factors","SUMO E3 ligases SUMOylate target proteins","Toll Like Receptor 5 (TLR5) Casca
de","SARS-CoV-2 Infection","Transcriptional Regulation by TP53","EPH-Ephrin signaling",Glycolysis,"Biosynthesis of D-series resolvins","Glycogen storage disease type II (GAA)","PCNA-Dependent Long Pat
ch Base Excision Repair","Post NMDA receptor activation events","HDR through Homologous Recombination (HRR)","Estrogen biosynthesis","Signalling to ERKs","Visual phototransduction","The role of Nef in
 HIV-1 replication and disease pathogenesis","SUMOylation of intracellular receptors","MyD88 cascade initiated on plasma membrane","SARS-CoV-2 Genome Replication and Transcription","Pregnenolone biosy
nthesis","Regulation of TP53 Activity","EPH-ephrin mediated repulsion of cells","Activation of AMPK downstream of NMDARs","Homologous DNA Pairing and Strand Exchange","Signalling to RAS","The canonica
l retinoid cycle in rods (twilight vision)","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","TAK1 activates NFkB by phosphorylation and activation of I
KKs complex","Replication of the SARS-CoV-2 genome","Regulation of TP53 Expression and Degradation","Nef and signal transduction","MAP kinase activation","Presynaptic phase of homologous DNA pairing a
nd strand exchange","p38MAPK events","Nef Mediated CD4 Down-regulation","Regulation of TP53 Degradation","MAPK targets/ Nuclear events mediated by MAP kinases","Activation of the AP-1 family of transc
ription factors"}

> <broad_targets>
{MCL1,TYR}

> <broad_moa>
{"GABA transaminase inhibitor"}

> <synonyms>
{20283-92-5,20283925,"Rosemary acid","(R)-rosmarinic acid","(R)rosmarinic acid",Rosmarinic-acid,Rosmarinicacid,Rosmarinate,"Labiatenic acid",UNII-MQE6XG29YI,UNIIMQE6XG29YI,MQE6XG29YI,CHEMBL324842,CHEB
I:50371,537-15-5,537155,MFCD00017740,(R)-O-(3,(R)O(3,4-Dihydroxycinnamoyl)-3-(,4Dihydroxycinnamoyl)3(,T2765,"Rosmarinic acid"}

> <pdid>
PD001391

> <targets>
{IKK-?/NF-?B,MAO-A,MAO-B,COMT,Apoptosis,"Endogenous Metabolite","Monoamine Oxidase"}

> <classes>
{Metabolism,Apoptosis,Metabolic Enzyme/Protease,Neuronal Signaling}

> <pubchem_cids>
{5281792}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 40  0  0  0  0            999 V2000
   -8.9814   -2.9992    0.0000 C   0  0
   -7.5416   -3.4196    0.0000 O   0  0
   -7.1846   -4.8774    0.0000 C   0  0
   -8.2701   -5.9126    0.0000 C   0  0
   -7.9164   -7.3703    0.0000 C   0  0
   -9.0046   -8.4038    0.0000 N   0  0
   -8.6534   -9.8621    0.0000 C   0  0
  -10.4441   -7.9791    0.0000 C   0  0
  -11.5323   -9.0126    0.0000 C   0  0
  -12.9718   -8.5878    0.0000 N   0  0
  -14.0594   -9.6208    0.0000 C   0  0
  -13.3230   -7.1295    0.0000 C   0  0
   -6.4771   -7.7928    0.0000 C   0  0
   -6.1201   -9.2506    0.0000 N   0  0
   -4.6795   -9.6712    0.0000 C   0  0
   -3.5958   -8.6341    0.0000 O   0  0
   -4.3225  -11.1290    0.0000 C   0  0
   -2.8827  -11.5494    0.0000 C   0  0
   -5.3916   -6.7576    0.0000 C   0  0
   -5.7452   -5.2998    0.0000 C   0  0
   -4.6570   -4.2663    0.0000 N   0  0
   -3.2175   -4.6910    0.0000 C   0  0
   -2.8628   -6.1485    0.0000 N   0  0
   -1.4233   -6.5700    0.0000 C   0  0
   -0.3384   -5.5341    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0
   -2.1327   -3.6551    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    3.8805   -1.4410    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
  5 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  2  0
 13 19  1  0
 19 20  2  0
 20  3  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 22  1  0
 26 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  1  0
 30 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 28  1  0
 37 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
29004

> <plate>
Kinase v5-3

> <well>
F12

> <supplier_cmpd_name>
Osimertinib

> <ctcr_id>
8367

> <supplier_cmpd_id>
Se S7297

> <smiles>
COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc2nccc(n2)c3cn(C)c4ccccc34

> <pd_targets>
{EGFR,INSR,KCNH2,GSC2,CTSC,ERBB2,ERBB3,ERBB4,REP,ALK,EML4}

> <pathway_gtopdb>
{Enzyme,"Ion channel",Kinase,"Voltage-gated ion channel",Transferase,Protease,"Protein Kinase","Potassium channels","Cysteine protease","TK protein kinase group","Voltage-gated potassium channel","Cys
teine protease CA clan","TKL protein kinase group","Tyrosine protein kinase EGFR family","Tyrosine protein kinase InsR family","Cysteine protease C1A family","TKL protein kinase STKR family","TKL prot
ein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Ion channels",Enzymes,"Other protein targets","Catalytic receptors","Voltage-gated ion channels","Peptidases and proteinases","Anti-infective targets","Receptor kinases","Potassium channel
s","CA: Cysteine (C) Peptidases","Viral protein targets","TK: Tyrosine kinase","Voltage-gated potassium channels","C1: Papain","Coronavirus (CoV) proteins","Receptor tyrosine kinases (RTKs)","Type I R
TKs: ErbB (epidermal growth factor) receptor family","Type II RTKs: Insulin receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family"}

> <pathway_reactome>
{"Signal Transduction","Muscle contraction","Metabolism of proteins",Disease,"Signaling by GPCR","Intracellular signaling by second messengers","Cardiac conduction","Post-translational protein modific
ation","Infectious disease","GPCR downstream signalling","PIP3 activates AKT signaling","Phase 3 - rapid repolarisation","Asparagine N-linked glycosylation","SARS-CoV Infections","G alpha (q) signalli
ng events","Negative regulation of the PI3K/AKT network","Transport to the Golgi and subsequent modification","SARS-CoV-2 Infection","Gastrin-CREB signalling pathway via PKC and MAPK",PI5P,"PP2A and I
ER3 Regulate PI3K/AKT Signaling","ER to Golgi Anterograde Transport","SARS-CoV-2 Genome Replication and Transcription","EGFR Transactivation by Gastrin","Cargo concentration in the ER","Replication of
 the SARS-CoV-2 genome"}

> <broad_targets>
{EGFR}

> <broad_moa>
{"EGFR inhibitor"}

> <synonyms>
{AZD-9291,AZD9291,1421373-65-0,1421373650,Mereletinib,"AZD 9291",Tagrisso,UNII-3C06JJ0Z2O,UNII3C06JJ0Z2O,"Osimertinib free base",3C06JJ0Z2O,"1421373-65-0 (free base)","1421373650 (free base)","Merelet
inib (INN)","Osimertinib (USAN)",osimertinibum,Tube720,"Osimertinib; AZD 9291",Osimertinib;,T3634,T2490,779217,"Osimertinib mesylate",Osimertinib}

> <pdid>
PD009249

> <targets>
{EGFR}

> <classes>
{JAK/STAT Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{71496458}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 24  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
    0.0000   -3.0000    0.0000 C   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -3.8971   -3.7500    0.0000 C   0  0
   -5.1961   -3.0000    0.0000 C   0  0
   -5.1962   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 N   0  0
    1.2978    3.7529    0.0000 C   0  0
    1.2954    5.2529    0.0000 C   0  0
   -0.0048    6.0009    0.0000 O   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
  1  2  2  0
  2  3  1  0
  3  4  2  3
  4  5  1  0
  5  6  2  3
  6  7  1  0
  7  2  1  0
  7  8  1  0
  8  9  2  3
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15 10  1  0
  4 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 16  1  0
M  END
> <name>
UTKinase_V5

> <id>
29008

> <plate>
Kinase v5-3

> <well>
F20

> <supplier_cmpd_name>
Compound 401

> <ctcr_id>
3616

> <supplier_cmpd_id>
3271

> <smiles>
O=C1C=C(N=C2N1C=Cc3ccccc23)N4CCOCC4

> <pd_targets>
{PRKDC,MTOR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","Atypical protein kinase group","Atypical protein kinase PIKK family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)",Atypical,"Phosphatidyl inositol 3' kinase-related kinases (PIKK) family","Other PIKK family kinases","FRAP subfamily"}

> <pathway_reactome>
{"Immune System","Gene expression (Transcription)","Innate Immune System","RNA Polymerase II Transcription","Cytosolic sensors of pathogen-associated DNA","Generic Transcription Pathway","STING mediat
ed induction of host immune responses","Transcriptional Regulation by TP53","IRF3-mediated induction of type I IFN","Regulation of TP53 Activity","Regulation of TP53 Expression and Degradation","Regul
ation of TP53 Degradation"}

> <broad_targets>
{MTOR,PRKDC}

> <broad_moa>
{"DNA dependent protein kinase inhibitor"}

> <synonyms>
{"Compound 401",168425-64-7,168425647,"2-morpholino-4H-pyrimido(2,1-a)isoquinolin-4-one","2morpholino4Hpyrimido(2,1a)isoquinolin4one","2-(morpholin-4-yl)pyrimido(2,1-a)isoquinolin-4-one","2(morpholin4
yl)pyrimido(2,1a)isoquinolin4one","2-(4-MORPHOLINYL)-4H-PYRIMIDO(2,1-A)ISOQUINOLIN-4-ONE","2(4MORPHOLINYL)4HPYRIMIDO(2,1A)ISOQUINOLIN4ONE",CHEMBL179242,4H-Pyrimido(2,4HPyrimido(2,1-a)isoquinolin-4-one
,1a)isoquinolin4one,2-(4-morph,2(4morph,T3586,3271,"EMD 234501",234501,"COMPOUND 401"}

> <pdid>
PD015722

> <targets>
{DNA-PK,"Compound 401"}

> <classes>
{}

> <pubchem_cids>
{10039361}

$$$$
UTKinase_V5
  SciTegic11012413002D

 41 45  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5972    1.5031    0.0000 N   0  0
    2.5951    3.0039    0.0000 C   0  0
    3.8915    3.7585    0.0000 N   0  0
    3.8863    5.2585    0.0000 C   0  0
    5.1819    6.0161    0.0000 N   0  0
    5.1746    7.5169    0.0000 C   0  0
    3.8703    8.2580    0.0000 C   0  0
    3.8600    9.7580    0.0000 C   0  0
    5.1538   10.5169    0.0000 C   0  0
    6.4580    9.7759    0.0000 C   0  0
    6.4684    8.2760    0.0000 C   0  0
    7.7733    7.5346    0.0000 S   0  0
    7.7833    6.0346    0.0000 O   0  0
    9.0772    6.7930    0.0000 O   0  0
    9.0683    8.2932    0.0000 C   0  0
   10.3725    7.5523    0.0000 C   0  0
    9.0583    9.7932    0.0000 C   0  0
    2.5847    6.0040    0.0000 N   0  0
    1.2883    5.2495    0.0000 C   0  0
    1.2934    3.7495    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987   -1.5004    0.0000 N   0  0
   -3.8991   -0.7525    0.0000 C   0  0
   -5.1969   -1.5046    0.0000 C   0  0
   -5.1945   -3.0046    0.0000 C   0  0
   -3.8943   -3.7525    0.0000 C   0  0
   -2.5964   -3.0004    0.0000 C   0  0
   -6.4930   -3.7570    0.0000 N   0  0
   -7.7945   -3.0112    0.0000 C   0  0
   -9.0912   -3.7653    0.0000 C   0  0
   -9.0864   -5.2653    0.0000 N   0  0
  -10.3830   -6.0194    0.0000 C   0  0
   -7.7850   -6.0112    0.0000 C   0  0
   -6.4883   -5.2571    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 15 16  1  0
 16 17  2  0
 16 18  2  0
 16 19  1  0
 19 20  1  0
 19 21  1  0
  8 22  2  0
 22 23  1  0
 23 24  2  0
 24  6  1  0
  4 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28  3  1  0
 27 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 29  1  0
 32 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 38 39  1  0
 38 40  1  0
 40 41  1  0
 41 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
29009

> <plate>
Kinase v5-3

> <well>
F22

> <supplier_cmpd_name>
ASP 3026

> <ctcr_id>
11906

> <supplier_cmpd_id>
5310

> <smiles>
COc1c(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)ncn2)ccc(c1)N1CCC(CC1)N1CCN(C)CC1

> <pd_targets>
{ALK}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TKL protein kinase group","TKL protein kinase STKR family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family"}

> <pathway_reactome>
{}

> <broad_targets>
{ALK}

> <broad_moa>
{"ALK tyrosine kinase receptor inhibitor"}

> <synonyms>
{ASP3026,1097917-15-1,1097917151,ASP-3026,"ASP 3026",UNII-HP4L6MXF10,UNIIHP4L6MXF10,HP4L6MXF10,F6O,cc-325,cc325,MLS006011176,GTPL7740,SCHEMBL2827739,CHEMBL3545360,C29H40N8O3S,AOB6601,DTXSID90149038,EX
-A140,EXA140,QCR-144,QCR144,CHEBI:167650,HMS3673C17,BCP06436,2229AH,MFCD21609265,NSC765865,T1962}

> <pdid>
PD012874

> <targets>
{ALK}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{25134326}

$$$$
UTKinase_V5
  SciTegic11012413002D

 43 51  0  0  1  0            999 V2000
   -4.6251    3.1704    0.0000 C   0  0
   -4.1487    2.2911    0.0000 O   0  0
   -2.6500    2.2500    0.0000 C   0  0  2  0  0  0
   -1.8100    3.5000    0.0000 C   0  0  1  0  0  0
   -0.2400    3.5200    0.0000 C   0  0
    0.5000    2.1800    0.0000 C   0  0  1  0  0  0
   -1.0600    2.1800    0.0000 O   0  0
   -1.8300    0.9300    0.0000 C   0  0  1  0  0  0
   -3.1401    0.1996    0.0000 C   0  0
   -0.9800   -0.7800    0.0000 N   0  0
   -2.1300   -1.4600    0.0000 C   0  0
   -3.3200   -0.7600    0.0000 C   0  0
   -4.5500   -1.4800    0.0000 C   0  0
   -4.5800   -2.7700    0.0000 C   0  0
   -3.3400   -3.4700    0.0000 C   0  0
   -2.1300   -2.7900    0.0000 C   0  0
    0.2400   -2.7700    0.0000 C   0  0
    1.4300   -3.4700    0.0000 C   0  0
    1.7600   -4.9700    0.0000 C   0  0
    3.2600   -5.0800    0.0000 N   0  0
    3.8500   -3.6300    0.0000 C   0  0
    5.2941   -3.2244    0.0000 O   0  0
    2.6600   -2.7500    0.0000 C   0  0
    2.6800   -1.4600    0.0000 C   0  0
    3.7900    0.5600    0.0000 C   0  0
    4.9600    1.2800    0.0000 C   0  0
    4.9600    2.6300    0.0000 C   0  0
    3.8100    3.2900    0.0000 C   0  0
    2.6400    2.5900    0.0000 C   0  0
    2.6400    1.2400    0.0000 C   0  0
    1.4900    0.5400    0.0000 N   0  0
    1.4500   -0.7600    0.0000 C   0  0
    0.2400   -1.4400    0.0000 C   0  0
   -2.5435    4.8102    0.0000 N   0  0
   -1.7763    6.0991    0.0000 C   0  0
   -4.0442    4.8306    0.0000 C   0  0
   -4.5556    3.9713    0.0000 O   0  0
   -4.7776    6.1400    0.0000 C   0  0
   -6.2775    6.1627    0.0000 C   0  0
   -7.0079    7.4728    0.0000 C   0  0
   -6.2384    8.7604    0.0000 C   0  0
   -4.7386    8.7379    0.0000 C   0  0
   -4.0082    7.4277    0.0000 C   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  4  5  1  0
  6  5  1  6
  6  7  1  0
  7  8  1  0
  8  3  1  0
  8  9  1  1
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 18  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 25  1  0
 30 31  1  0
 31  6  1  0
 31 32  1  0
 32 24  1  0
 32 33  2  0
 33 10  1  0
 33 17  1  0
  4 34  1  6
 34 35  1  0
 34 36  1  0
 36 37  2  0
 36 38  1  0
 38 39  2  0
 39 40  1  0
 40 41  2  0
 41 42  1  0
 42 43  2  0
 43 38  1  0
M  END
> <name>
UTKinase_V5

> <id>
29012

> <plate>
Kinase v5-3

> <well>
H14

> <supplier_cmpd_name>
Midostaurin

> <ctcr_id>
6387

> <supplier_cmpd_id>
S8064

> <smiles>
CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35)N(C)C(=O)c9ccccc9

> <pd_targets>
{FLT3,DYRK1A,PDPK1,MAPK9,PHKG1,PIP5K1A,TYRO3,WEE1,STK25,ZAP70,PRKACB,PTK2B,CSK,TEK,NTRK2,NTRK3,EGFR,NUAK1,AURKA,PDGFRB,PIM2,AXL,MARK2,MARK4,MET,CAMK2B,CAMKK2,STK16,HIPK3,PRKCD,PRKCE,PRKD2,PRKD3,RET,FG
FR1,FGFR2,JAK3,MAPK10,KIT,SRPK2,TSSK1B,FYN,GAK,ALK,DDR1,AKT2,LCK,LTK,LYN,LRRK2,TIE1,TNK2,NTRK1,PDGFRA,PIM1,PIM3,CAMK1D,CAMK1G,CAMKK1,PKN1,PLK4,PRKG2,EIF2AK2,GSK3B,MAPK8,MAP2K3,EIF2AK4,HCK,MAP3K9,CSF1R
,PAK1,PAK2,FRK,SRC,RPS6KA1,RPS6KA3,RPS6KA4,RPS6KA5,MAP4K2,MINK1,PRPF4B,RIOK2,DAPK3,GSK3A,IKBKE,MARK3,AAK1,ABL1,STK4,MAP3K11,ROCK1,ULK3,STK3,CHEK1,CLK2,CLK4,SLK,SIK1,FLT1,ROS1,ERN1,GRK1,GRK4,HIPK4,MAP3
K13,MAP3K3,SIK2,PRKAA1,DMPK,LATS2,STK10,RPS6KB1,JAK1,RIOK3,SRPK1,TNK1,PRKAA2,AKT1,AKT3,LATS1,STK17A,SGK3,FLT4,PAK3,PRKX,CLK1,CLK3,PHKG2,BRSK1,MAP4K4,MAP4K5,MAP2K6,MERTK,CAMK2G,PKN2,PRKCQ,FER,PRKG1,RPS
6KA6,YES1,PIP4K2B,PIK3CA,MAP4K1,MAP4K3,AURKB,BMP2K,BLK,MAP2K4,CSNK2A1,STK17B,TYK2,STK11,IRAK3,CDK19,AURKC,CILK1,EPHB6,CHUK,ROCK2,SRPK3,TBK1,TNKS2,TTK,MELK,CAMK1,NUAK2,FGFR3,RPS6KA2,PIK3C2G,PRKCA,MAP3K
7,STK32A,MYLK4,TNIK,PRKACA,MARK1,JAK2,RIOK1,DYRK1B,MYLK,FGR,HIPK2,HUNK,KDR,CAMK2A,SYK,PRKCH,STK33,MYLK3,DAPK2,MKNK2,BRSK2,MAST1,GRK7,MAP3K2,SIK3,MAP3K19,CAMK2D,TUBA1A,MAP3K10,ERBB4,PIK3C2B,DSTYK,CDPK1
,DAPK1,IKBKB,PRKCB,PRKCG,PRKCI,PRKCZ,PRKD1,PRKACG}

> <pathway_gtopdb>
{Enzyme,"Unclassified protein","Structural protein",Kinase,Transferase,"Protein Kinase","TK protein kinase group","CMGC protein kinase group","AGC protein kinase group","CAMK protein kinase group","Ot
her protein kinase group","STE protein kinase group","TKL protein kinase group","Atypical protein kinase group","Tyrosine protein kinase PDGFR family","CMGC protein kinase DYRK family","AGC protein ki
nase PDK1 subfamily","CMGC protein kinase MAPK family","CAMK protein kinase PHk family","Tyrosine protein kinase Axl family","Other protein kinase WEE family","STE protein kinase STE20 family","Tyrosi
ne protein kinase Syk family","AGC protein kinase PKA family","Tyrosine protein kinase Fak family","Tyrosine protein kinase Csk family","Tyrosine protein kinase Tie family","Tyrosine protein kinase Tr
k family","Tyrosine protein kinase EGFR family","CAMK protein kinase CAMK1 family","Other protein kinase AUR family","CAMK protein kinase PIM family","Tyrosine protein kinase Met family","CAMK protein
 kinase CAMK2 family","Other protein kinase CAMKK family","Other protein kinase NAK family","AGC protein kinase PKC family","CAMK protein kinase PKD family","Tyrosine protein kinase Ret family","Tyros
ine protein kinase FGFR family","Tyrosine protein kinase JakA family","CMGC protein kinase SRPK family","CAMK protein kinase TSSK family","Tyrosine protein kinase Src family","TKL protein kinase STKR 
family","Tyrosine protein kinase DDR family","AGC protein kinase AKT family","Tyrosine protein kinase Alk family","TKL protein kinase LRRK family","Tyrosine protein kinase Ack family","AGC protein kin
ase PKN family","Other protein kinase PLK family","AGC protein kinase PKG family","Other protein kinase PEK family","CMGC protein kinase GSK family","STE protein kinase STE7 family","TKL protein kinas
e MLK family","AGC protein kinase RSK family","Atypical protein kinase RIO family","CAMK protein kinase DAPK family","Tyrosine protein kinase Abl family","AGC protein kinase DMPK family","Other protei
n kinase ULK family","CMGC protein kinase CLK family","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase Sev family","AGC protein kinase GRK family","STE protein kinase STE11 family","AGC
 protein kinase NDR family","AGC protein kinase SGK family","Tyrosine protein kinase Fer family","Other protein kinase CK2 family","TKL protein kinase IRAK family","CMGC protein kinase CDK family","CM
GC protein kinase RCK family","Other protein kinase IKK family","Other protein kinase TTK family","AGC protein kinase YANK family","CAMK protein kinase MLCK family","CAMK protein kinase unique family"
,"CAMK protein kinase MAPKAPK family","AGC protein kinase MAST family","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase JNK subfamily","STE protein kinase YSK subfamily","CAMK protein kinase
 NuaK subfamily","CAMK protein kinase MARK subfamily","Other protein kinase Meta subfamily","CMGC protein kinase HIPK subfamily","AGC protein kinase PKC delta subfamily","AGC protein kinase PKC eta su
bfamily","Tyrosine protein kinase SrcA","TKL protein kinase STKR Type 1 subfamily","Other protein kinase PKR","Other protein kinase GCN2 subfamily","TKL protein kinase MLK subfamily","STE protein kina
se PAKA subfamily","AGC protein kinase RSK subfamily","AGC protein kinase MSK subfamily","STE protein kinase KHS subfamily","STE protein kinase MSN subfamily","Atypical protein kinase RIO2 subfamily",
"STE protein kinase MST subfamily","AGC protein kinase ROCK subfamily","CAMK protein kinase CHK1 subfamily","STE protein kinase SLK subfamily","CAMK protein kinase QIK subfamily","AGC protein kinase G
RK subfamily","TKL protein kinase LZK subfamily","STE protein kinase MEKK2","CAMK protein kinase AMPK subfamily","AGC protein kinase GEK subfamily","AGC protein kinase p70 subfamily","Atypical protein
 kinase RIO3 subfamily","CAMK protein kinase BRSK subfamily","CAMK protein kinase LKB subfamily","CMGC protein kinase CDK8 subfamily","CMGC protein kinase MAK","CAMK protein kinase MELK subfamily","AG
C protein kinase PKC alpha subfamily","TKL protein kinase TAK1 subfamily","Atypical protein kinase RIO1 subfamily","CAMK protein kinase MNK subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,"Other protein targets","Catalytic receptors","Kinases (EC 2.7.x.x)","Poly ADP-ribose polymerases",Tubulins,"Receptor kinases","CMGC: Containing CDK",MAPK,GSK3,"CLK families","AGC: 
Containing PKA",PKG,"PKC families","CAMK: Calcium/calmodulin-dependent protein kinases","Lipid modifying kinases","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases",Atypical,"TK: Tyr
osine kinase","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","PDK1 family","Mitogen-activated protein kinases (MAP kinases)","Phosphorylase kinase (PHK) family","Type I
 PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)","Other protein kinases","STE20 family","Protein kinase A (PKA) family","CAMK-like (CAMKL) family","PIM family","CAMK2 family","Protei
n kinase C (PKC) family","Protein kinase D (PKD) family","SRPK family","Testis specific kinase (TSSK) family","Akt (Protein kinase B","PKB) family","TKL: Tyrosine kinase-like","CAMK1 family","Protein 
kinase N (PKN) family","Protein kinase G (PKG) family","Glycogen synthase kinase (GSK) family","STE7 family","RSK family","RIO family","Death-associated kinase (DAPK) family","DMPK family","CLK family
","G protein-coupled receptor kinases (GRKs)","STE11 family","NDR family","SGK family","Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)",Phosphatidylinositol-4,"5-bisphosphate
 3-kinase family","Cyclin-dependent kinase (CDK) family","RCK family","Phosphatidylinositol-4-phosphate 3-kinase family","YANK family","Myosin Light Chain Kinase (MLCK) family","CAMK-unique family","M
APK-Activated Protein Kinase (MAPKAPK) family","MAST family","Receptor tyrosine kinases (RTKs)","Dyrk1 subfamily","JNK subfamily","WEE family","YSK subfamily","Non-receptor tyrosine kinases (nRTKs)","
NuaK subfamily","Aurora kinase (Aur) family","MARK subfamily","CAMKK family","NAK family","HIPK subfamily","Delta subfamily","Eta subfamily","Numb-associated kinase (NAK) family","Leucine-rich repeat 
kinase (LRRK) family","Polo-like kinase (PLK) family","PEK family","GSK subfamily","Mixed Lineage Kinase (MLK) family","PAKA subfamily","RSK subfamily","MSK subfamily","KHS subfamily","MSN subfamily",
"PRP4 subfamily","RIO2 subfamily","IKK family","MST subfamily","Rho kinase","Unc-51-like kinase (ULK) family","CHK1 subfamily","SLK subfamily","QIK subfamily","IRE family","Opsin/rhodopsin kinases","G
RK4 subfamily","AMPK subfamily","GEK subfamily","p70 subfamily","RIO3 subfamily","BRSK subfamily","Casein kinase 2 (CK2) family","LKB subfamily","Interleukin-1 receptor-associated kinase (IRAK) family
","CDK8 subfamily","TTK family","MELK subfamily","RIO1 subfamily","HUNK subfamily","MKN subfamily","STE20 subfamily","Other-unique family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type 
XI RTKs: TAM (TYRO3-","AXL- and MER-TK) receptor family","Syk family","Fak family","Csk family","Type XII RTKs: TIE family of angiopoietin receptors","Type VII RTKs: Neurotrophin receptor/Trk family",
"Type I RTKs: ErbB (epidermal growth factor) receptor family","Type X RTKs: HGF (hepatocyte growth factor) receptor family","Meta subfamily","Type XIV RTKs: RET","Type V RTKs: FGF (fibroblast growth f
actor) receptor family","Janus kinase (JakA) family","Src family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family","Type XVI RTKs: DDR (collagen receptor) family","Ack family","Other P
EK family kinases","GCN2 subfamily","MLK subfamily","Abl family","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type XVII RTKs: ROS receptors","LZK subfamily","Fer family",
"Type XIII RTKs: Ephrin receptor family","TAK1 subfamily"}

> <pathway_reactome>
{"Signal Transduction","Cell Cycle","Gene expression (Transcription)","Immune System",Metabolism,Disease,"Organelle biogenesis and maintenance","Developmental Biology","Neuronal System","Vesicle-media
ted transport","Extracellular matrix organization","Cellular responses to external stimuli","Metabolism of RNA","Programmed Cell Death","DNA Repair","Circadian Clock","Metabolism of proteins","Muscle 
contraction","Transport of small molecules",Hemostasis,"Signaling by Receptor Tyrosine Kinases",Mitotic,"RNA Polymerase II Transcription","Innate Immune System","Metabolism of carbohydrates","Metaboli
sm of lipids","Cell Cycle Checkpoints","Adaptive Immune System","Intracellular signaling by second messengers","Cytokine Signaling in Immune system","Diseases of signal transduction by growth factor r
eceptors and second messengers","MAPK family signaling cascades","Signaling by GPCR","Cilium Assembly","Nervous system development","Transmission across Chemical Synapses","Infectious disease","Membra
ne Trafficking","Non-integrin membrane-ECM interactions","Signaling by Non-Receptor Tyrosine Kinases","Signaling by Rho GTPases","Cellular responses to stress","rRNA processing",Apoptosis,"Signaling b
y Hippo","Signaling by Hedgehog","DNA Double-Strand Break Repair","Unfolded Protein Response (UPR)","Cardiac conduction","MTOR signalling","Ion channel transport","Cell surface interactions at the vas
cular wall","Platelet homeostasis","Signaling by Insulin receptor","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Toll-like Receptor Cascades","Glycogen metabolism","Phospholi
pid metabolism","G2/M Checkpoints","TCR signaling","DAG and IP3 signaling","Signaling by Interleukins","Oncogenic MAPK signaling","MAPK1/MAPK3 signaling","Signaling by NTRKs","GPCR downstream signalli
ng","PIP3 activates AKT signaling","Signaling by VEGF","Anchoring of the basal body to the plasma membrane","Axon guidance","Neurotransmitter receptors and postsynaptic signal transmission","Fcgamma r
eceptor (FCGR) dependent phagocytosis","Sphingolipid metabolism","Signaling by FGFR in disease","Signaling by KIT in disease","HIV Infection","trans-Golgi Network Vesicle Budding","Leishmania infectio
n","Signaling by PTK6","Signaling by PDGFR in disease","FLT3 signaling in disease","RHO GTPase Effectors","Mitotic G2-G2/M phases","Influenza Infection","SARS-CoV Infections","Response of EIF2AK4 (GCN
2) to amino acid deficiency","Cellular Senescence","rRNA processing in the nucleus and cytosol","Caspase activation via extrinsic apoptotic signalling pathway","Clathrin-mediated endocytosis","Hedgeho
g 'on' state","Homology Directed Repair","IRE1alpha activates chaperones","Ion homeostasis","Neutrophil degranulation","mTORC1-mediated signalling","Interferon Signaling","Stimuli-sensing channels","S
ignaling by SCF-KIT","Nitric oxide stimulates guanylate cyclase","M Phase","Regulation of lipid metabolism by PPARalpha","Insulin receptor signalling cascade","G0 and Early G1","Transcriptional Regula
tion by TP53","Toll Like Receptor 5 (TLR5) Cascade","Glycogen breakdown (glycogenolysis)","PI Metabolism","G2/M DNA damage checkpoint","Generation of second messenger molecules","CaM pathway","Interle
ukin-2 family signaling","Signaling by RAS mutants","RAF/MAP kinase cascade","Signaling by NTRK1 (TRKA)","Signaling by NTRK3 (TRKC)","G alpha (q) signalling events","Negative regulation of the PI3K/AK
T network","VEGFA-VEGFR2 Pathway","Semaphorin interactions","Activation of NMDA receptors and postsynaptic events","Role of phospholipids in phagocytosis","Sphingolipid de novo biosynthesis","RET sign
aling","Signaling by FGFR1 in disease","Signaling by FGFR2 in disease","Drug resistance of KIT mutants","Host Interactions of HIV factors","Golgi Associated Vesicle Biogenesis","Leishmania parasite gr
owth and survival","PTK6 promotes HIF1A stabilization","Drug resistance of PDGFR mutants","Signaling by FLT3 ITD and TKD mutants","RHO GTPases activate PKNs","G2/M Transition","NS1 Mediated Effects on
 Host Pathways","SARS-CoV-1 Infection","Transcriptional Regulation by VENTX","EPH-Ephrin signaling","PTEN Regulation","L1CAM interactions","Oxidative Stress Induced Senescence","Major pathway of rRNA 
processing in the nucleolus and cytosol","Caspase activation via Dependence Receptors in the absence of ligand","Toll Like Receptor 4 (TLR4) Cascade","Cargo recognition for clathrin-mediated endocytos
is","Parasite infection","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","VEGF ligand-receptor interactions","G alpha (i) signalling events","Interleukin-1 family signali
ng","Antiviral mechanism by IFN-stimulated genes","cGMP effects","Mitotic Metaphase and Anaphase","Transcriptional regulation by RUNX1","Interferon alpha/beta signaling","Toll Like Receptor 2 (TLR2) C
ascade","PPARA activates gene expression","Signaling by FGFR3 in disease","G1 Phase","RHO GTPases activate PAKs","G alpha (z) signalling events","IRS-mediated signalling","Regulation of TP53 Activity"
,"MyD88 cascade initiated on plasma membrane","Synthesis of PIPs at the plasma membrane","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","Calmodulin induced events","Interleukin-2 sig
naling","Signaling downstream of RAS mutants","Activation of TRKA receptors","Activated NTRK3 signals through PI3K","Gastrin-CREB signalling pathway via PKC and MAPK",PI5P,"PP2A and IER3 Regulate PI3K
/AKT Signaling","Sema4D in semaphorin signaling","Post NMDA receptor activation events","FGFR1 mutant receptor activation","FGFR2 mutant receptor activation","Interleukin-15 signaling","Dasatinib-resi
stant KIT mutants","The role of Nef in HIV-1 replication and disease pathogenesis","Anti-inflammatory response favouring Leishmania parasite infection","Signalling to ERKs","Imatinib-resistant PDGFR m
utants","STAT5 activation downstream of FLT3 ITD mutants","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Centrosome maturation","RAS processing","In
hibition of PKR","SARS-CoV-1 Genome Replication and Transcription","EPHB-mediated forward signaling","Regulation of PTEN stability and activity","Recycling pathway of L1","MyD88-independent TLR4 casca
de","Leishmania phagocytosis","HDR through Homologous Recombination (HRR)","VEGF binds to VEGFR leading to receptor dimerization","Visual phototransduction","Interleukin-1 signaling","ISG15 antiviral 
mechanism","Ephrin signaling","Mitotic Anaphase","RUNX1 regulates transcription of genes involved in BCR signaling","Regulation of IFNA signaling","Toll Like Receptor TLR6:TLR2 Cascade","Signaling by 
FGFR3 point mutants in cancer","Synthesis of PIPs at the Golgi membrane","Cyclin D associated events in G1","VEGFR2 mediated cell proliferation","PI3K Cascade","Regulation of TP53 Expression and Degra
dation","MAP kinase activation","PKA-mediated phosphorylation of CREB","NGF-independant TRKA activation","EGFR Transactivation by Gastrin","Regulation of TP53 Activity through Phosphorylation","Sema4D
 mediated inhibition of cell attachment and migration","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Activation of AMPK downstream of NMDARs","Signaling by activa
ted point mutants of FGFR1","Activated point mutants of FGFR2","Nef and signal transduction","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters","FCGR3A-me
diated IL10 synthesis","Prolonged ERK activation events","Activation of RAC1 downstream of NMDARs","Loss of proteins required for interphase microtubule organization from the centrosome","Replication 
of the SARS-CoV-1 genome","Signalling to RAS","TRIF(TICAM1)-mediated TLR4 signaling","FCGR3A-mediated phagocytosis","Sema4D induced cell migration and growth-cone collapse","Homologous DNA Pairing and
 Strand Exchange","The phototransduction cascade","ADORA2B mediated anti-inflammatory cytokines production","Regulation of TP53 Activity through Acetylation","Signaling by cytosolic FGFR1 fusion mutan
ts","Separation of Sister Chromatids","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","FGFR3 mutant receptor activation","Long-term potentiation","Regulation of TP53 Degradation","MAPK targets
/ Nuclear events mediated by MAP kinases","PKA activation","Ras activation upon Ca2+ influx through NMDA receptor","PKB-mediated events","Nef Mediated CD4 Down-regulation","ARMS-mediated activation","
Loss of Nlp from mitotic centrosomes","activated TAK1 mediates p38 MAPK activation","p38MAPK events","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","Presynaptic phase of homologous DNA pairing
 and strand exchange",Inactivation,"recovery and regulation of the phototransduction cascade","PI5P Regulates TP53 Acetylation","RSK activation","JNK (c-Jun kinases) phosphorylation and  activation me
diated by activated human TAK1","IKK complex recruitment mediated by RIP1","Signaling by activated point mutants of FGFR3","TRAF6-mediated induction of TAK1 complex within TLR4 complex","Activation of
 the AP-1 family of transcription factors","PDE3B signalling","CREB phosphorylation"}

> <broad_targets>
{FLT3,PRKCG}

> <broad_moa>
{"FLT3 inhibitor","KIT inhibitor","PKC inhibitor"}

> <synonyms>
{Midostaurin,PKC412,120685-11-2,120685112,"Cgp 41251",Benzoylstaurosporine,PKC-412,"PKC 412",4'-N-Benzoylstaurosporine,4'NBenzoylstaurosporine,CGP-41251,CGP41251,RYDAPT,UNII-ID912S5VON,UNIIID912S5VON,
ID912S5VON,CHEMBL608533,CHEBI:63452,"Cgp 41 251","Midostaurin (USAN:INN)","Rydapt (TN)",Midostaurin(PKC412),"EMD 539648",EI-370,539648}

> <pdid>
PD021374

> <targets>
{"multi kinase",PKC}

> <classes>
{}

> <pubchem_cids>
{9829523}

$$$$
UTKinase_V5
  SciTegic11012413002D

 35 39  0  0  0  0            999 V2000
   10.3915   -7.4956    0.0000 Cl  0  0
   10.3938   -5.9956    0.0000 C   0  0
   11.6940   -5.2477    0.0000 N   0  0
   11.6964   -3.7477    0.0000 C   0  0
   10.3985   -2.9956    0.0000 C   0  0
    9.0982   -3.7435    0.0000 C   0  0
    9.0960   -5.2436    0.0000 C   0  0
    7.7985   -2.9932    0.0000 C   0  0
    7.7985   -1.4932    0.0000 N   0  0
    6.4994   -0.7432    0.0000 C   0  0
    6.4994    0.7568    0.0000 C   0  0
    5.2003   -1.4932    0.0000 C   0  0
    5.2004   -2.9933    0.0000 C   0  0
    6.4995   -3.7432    0.0000 N   0  0
    3.9008   -3.7437    0.0000 C   0  0
    2.6028   -2.9918    0.0000 C   0  0
    1.3026   -3.7398    0.0000 C   0  0
    1.3003   -5.2398    0.0000 C   0  0
    0.0001   -5.9878    0.0000 Cl  0  0
    2.5982   -5.9918    0.0000 C   0  0
    3.8984   -5.2438    0.0000 C   0  0
    5.1963   -5.9958    0.0000 F   0  0
    3.8990   -0.7455    0.0000 C   0  0
    3.8964    0.7545    0.0000 O   0  0
    2.6003   -1.4977    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.3115    2.9665    0.0000 C   0  0
   -1.8032    3.1233    0.0000 N   0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 F   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  3
 12 13  1  0
 13 14  1  0
 14  8  2  3
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 18 20  1  0
 20 21  2  0
 21 15  1  0
 21 22  1  0
 12 23  1  0
 23 24  2  0
 23 25  1  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  1  0
 31 32  2  0
 32 28  1  0
 32 33  1  0
 33 34  2  0
 34 26  1  0
 34 35  1  0
M  END
> <name>
UTKinase_V5

> <id>
29013

> <plate>
Kinase v5-3

> <well>
H16

> <supplier_cmpd_name>
GSK-25

> <ctcr_id>
12418

> <supplier_cmpd_id>
SY-GSK-25

> <smiles>
Clc1nccc(c1)C=2NC(C)=C(C(N=2)c3ccc(Cl)cc3F)C(=O)Nc4cc5cnnc5cc4F

> <pd_targets>
{RPS6KA1,CYP3A4,CYP2D6,RPS6KB1,CYP2C9,ROCK1}

> <pathway_gtopdb>
{Enzyme,Kinase,"Cytochrome P450","Protein Kinase","Cytochrome P450 family 3","Cytochrome P450 family 2","AGC protein kinase group","Cytochrome P450 family 3A","Cytochrome P450 family 2D","Cytochrome P
450 family 2C","AGC protein kinase RSK family","Cytochrome P450 3A4","Cytochrome P450 2D6","Cytochrome P450 2C9","AGC protein kinase DMPK family","AGC protein kinase RSK subfamily","AGC protein kinase
 p70 subfamily","AGC protein kinase ROCK subfamily"}

> <pathway_chembl>
{Enzymes,"Kinases (EC 2.7.x.x)","Cytochrome P450","AGC: Containing PKA",PKG,"PKC families","CYP3 family","CYP2 family: drug metabolising subset","RSK family","DMPK family","RSK subfamily","p70 subfami
ly","Rho kinase"}

> <pathway_reactome>
{"Immune System",Metabolism,"Signal Transduction","Developmental Biology","Innate Immune System","Metabolism of lipids","Biological oxidations","MTOR signalling","Nervous system development","Toll-lik
e Receptor Cascades","Biosynthesis of specialized proresolving mediators (SPMs)","Phase I - Functionalization of compounds","mTORC1-mediated signalling","Axon guidance","Toll Like Receptor 5 (TLR5) Ca
scade","Biosynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","Semaphorin interactions","MyD88 cascade initiated on plasma membrane","Biosynthesis of maresins",Xenobiotics,"
Sema4D in semaphorin signaling","MAP kinase activation","Biosynthesis of maresin-like SPMs","CYP2E1 reactions","Sema4D induced cell migration and growth-cone collapse","MAPK targets/ Nuclear events me
diated by MAP kinases","CREB phosphorylation"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{SK2,GSK-25,GSK25,874119-56-9,874119569,"Dihydropyrimidine, 25",C24H16Cl2F2N6O,CHEMBL521347,"GSK25;GSK 25",SCHEMBL4932798,BDBM25496,SYN1124,BCP21619,MFCD18782716,AKOS027420929,NCGC00345842-01,NCGC0034
584201,NCGC00345842-02,NCGC0034584202,AS-16264,AS16264,HY-14362,HY14362,CS-0003310,CS0003310,T4488}

> <pdid>
PD098473

> <targets>
{RSK1,"mTOR (p70S6K)"}

> <classes>
{"PI3K/Akt/mTOR signaling","PI3K/Akt/mTOR signaling"}

> <pubchem_cids>
{11548023}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 39  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -2.6044    2.9986    0.0000 C   0  0
   -3.9039    3.7478    0.0000 C   0  0
   -3.9049    5.2478    0.0000 C   0  0
   -2.6064    5.9986    0.0000 C   0  0
   -1.3068    5.2495    0.0000 C   0  0
   -0.0060    5.9981    0.0000 C   0  0
    1.2932    5.2467    0.0000 N   0  0
    2.5944    5.9930    0.0000 C   0  0
    3.8913    5.2394    0.0000 C   0  0
    3.8871    3.7394    0.0000 O   0  0
    2.5860    2.9930    0.0000 C   0  0
    1.2890    3.7466    0.0000 C   0  0
   -1.3058    3.7495    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -5.1992   -2.9856    0.0000 S   0  0
   -5.1935   -1.4856    0.0000 O   0  0
   -6.4953   -2.2305    0.0000 O   0  0
   -6.5020   -3.7306    0.0000 N   0  0
   -7.7992   -2.9757    0.0000 C   0  0
   -9.1013   -3.7204    0.0000 C   0  0
   -7.7935   -1.4758    0.0000 C   0  0
   -9.0952   -2.2206    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 13  1  0
 11 19  2  0
 19  7  1  0
  5 20  1  0
 20 21  2  0
 21  2  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 27 29  1  0
 29 30  2  0
 29 31  2  0
 29 32  1  0
 32 33  1  0
 33 34  1  0
 33 35  1  0
 33 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
29014

> <plate>
Kinase v5-3

> <well>
H18

> <supplier_cmpd_name>
TG-89

> <ctcr_id>
280

> <supplier_cmpd_id>
SY-TG-89

> <smiles>
Cc1cnc(Nc2cccc(CN3CCOCC3)c2)nc1Nc4cccc(c4)[S](=O)(=O)NC(C)(C)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{G8,936091-56-4,936091564,TG-89,TG89,cc-107,cc107,SCHEMBL266638,DTXSID00587366,SYN1107,BBL103534,LT0085,STL557344,ZINC67176020,AKOS005259273,EX-8666,EX8666,NCGC00345845-01,NCGC0034584501,NCGC00345845-
02,NCGC0034584502,AS-16251,AS16251,DB-079624,DB079624,FT-0755081,FT0755081,091D564,J-523768,J523768,SY-TG-89}

> <pdid>
PD132032

> <targets>
{JAK2}

> <classes>
{}

> <pubchem_cids>
{16723044}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 33  0  0  1  0            999 V2000
    6.9868   -0.4543    0.0000 O   0  0
    5.6877    0.2956    0.0000 C   0  0
    5.3046   -1.1546    0.0000 C   0  0
    3.8990   -0.7455    0.0000 N   0  0
    4.2375    0.6788    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    2.6030   -2.9977    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 F   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 F   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0031   -3.0008    0.0000 N   0  0
   -1.2946   -3.7547    0.0000 C   0  0
   -2.5943   -3.0056    0.0000 C   0  0
   -3.8928   -3.7565    0.0000 C   0  0
   -3.8918   -5.2565    0.0000 C   0  0
   -5.1904   -6.0073    0.0000 I   0  0
   -2.5923   -6.0056    0.0000 C   0  0
   -1.2937   -5.2548    0.0000 C   0  0
    0.0058   -6.0039    0.0000 F   0  0
    5.6777    1.7931    0.0000 C   0  0  2  0  0  0
    4.3736    2.5343    0.0000 C   0  0
    4.3635    4.0343    0.0000 C   0  0
    5.6575    4.7930    0.0000 C   0  0
    6.9616    4.0518    0.0000 C   0  0
    6.9716    2.5518    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  2  1  0
  4  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 13 15  2  0
 15  8  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 22 23  2  0
 23 17  1  0
 23 24  1  0
 25  2  1  6
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 25  1  0
M  END
> <name>
UTKinase_V5

> <id>
29018

> <plate>
Kinase v5-3

> <well>
J12

> <supplier_cmpd_name>
Cobimetinib

> <ctcr_id>
8366

> <supplier_cmpd_id>
S8041

> <smiles>
OC1(CN(C1)C(=O)c2ccc(F)c(F)c2Nc3ccc(I)cc3F)[C@@H]4CCCCN4

> <pd_targets>
{MAP2K2,MAP2K1,MAP2K7,BRAF}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","STE protein kinase group","TKL protein kinase group","STE protein kinase STE7 family","TKL protein kinase RAF family"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","STE: Homologs of yeast Sterile 7","Sterile 11","Sterile 20 kinases","Receptor kinases","STE7 family","TKL: Tyrosine kinase-like","RAF f
amily"}

> <pathway_reactome>
{"Signal Transduction","Immune System","Signaling by Receptor Tyrosine Kinases","Innate Immune System","Signaling by NTRKs","Toll-like Receptor Cascades","Signaling by NTRK1 (TRKA)","Toll Like Recepto
r 5 (TLR5) Cascade","Signalling to ERKs","MyD88 cascade initiated on plasma membrane","Prolonged ERK activation events","MAP kinase activation","Frs2-mediated activation","JNK (c-Jun kinases) phosphor
ylation and  activation mediated by activated human TAK1","ARMS-mediated activation"}

> <broad_targets>
{MAP2K1}

> <broad_moa>
{"MEK inhibitor"}

> <synonyms>
{Cobimetinib,934660-93-2,934660932,GDC-0973,GDC0973,XL518,Cotellic,Xl-518,Xl518,"GDC 0973",RG7420,"RG 7420",UNII-ER29L26N1X,UNIIER29L26N1X,"XL 518","Cobimetinib (GDC-0973, RG7420)","Cobimetinib (GDC09
73, RG7420)",ER29L26N1X,C21H21F3IN3O2,CHEMBL2146883,EUI,"Cobimetinib Butyrate",934660-94-3,934660943,"Cobimetinib (USAN:INN)",T3623,768068}

> <pdid>
PD009336

> <targets>
{MEK1}

> <classes>
{}

> <pubchem_cids>
{16222096}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  1  0            999 V2000
    0.8906   -7.7543    0.0000 C   0  0
    0.8403   -6.2551    0.0000 C   0  0
   -0.4810   -5.5489    0.0000 C   0  0  2  0  0  0
   -1.8348   -6.1949    0.0000 C   0  0
   -2.8675   -5.1069    0.0000 N   0  0
   -2.1519   -3.7886    0.0000 C   0  0
   -0.6928   -4.0817    0.0000 C   0  0  2  0  0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 C   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.7248    1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 N   0  0
   -4.3533   -5.2996    0.0000 C   0  0
   -4.9296   -6.6845    0.0000 O   0  0
   -5.2654   -4.1077    0.0000 N   0  0
   -6.7537   -4.3007    0.0000 C   0  0
   -7.6658   -3.1088    0.0000 C   0  0
   -9.1533   -3.3017    0.0000 F   0  0
   -8.5768   -1.9171    0.0000 F   0  0
   -7.0895   -1.7239    0.0000 F   0  0
  1  2  1  0
  3  2  1  6
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  3  1  0
  7  8  1  6
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 14  1  0
 18 19  1  0
 19 11  1  0
 19  8  1  0
  5 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 24 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
29019

> <plate>
Kinase v5-3

> <well>
J14

> <supplier_cmpd_name>
Upadacitinib

> <ctcr_id>
11536

> <supplier_cmpd_id>
S8162

> <smiles>
CC[C@@H]1CN(C[C@@H]1c4cnc3cnc2nccc2n34)C(=O)NCC(F)(F)F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{Upadacitinib,1310726-60-3,1310726603,ABT-494,ABT494,Rinvoq,UNII-4RA0KN46E0,UNII4RA0KN46E0,4RA0KN46E0,"1310726-60-3 (free base)","1310726603 (free base)",MFCD30502663,"Upadacitinib, ABT-494","Upadacit
inib, ABT494","Upadacitinib (USAN/INN)","Upadacitinib (USAN:INN)","Upadacitinib (ABT-494)","Upadacitinib (ABT494)",GTPL9246,SCHEMBL9991056,CHEMBL362,T7503}

> <pdid>

> <targets>
{JAK1,JAK2}

> <classes>
{"JAK/STAT signaling"}

> <pubchem_cids>
{58557659}

$$$$
UTKinase_V5
  SciTegic11012413002D

 36 39  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.6003    1.4977    0.0000 N   0  0
   -2.6044    2.9986    0.0000 C   0  0
   -3.9039    3.7478    0.0000 C   0  0
   -3.9049    5.2478    0.0000 C   0  0
   -2.6064    5.9986    0.0000 C   0  0
   -2.6043    7.4995    0.0000 C   0  0
   -1.3039    8.2489    0.0000 N   0  0
   -1.2996    9.7489    0.0000 C   0  0
    0.0015   10.4953    0.0000 C   0  0
    1.2984    9.7416    0.0000 O   0  0
    1.2942    8.2417    0.0000 C   0  0
   -0.0069    7.4953    0.0000 C   0  0
   -1.3068    5.2495    0.0000 C   0  0
   -1.3058    3.7495    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031   -3.0008    0.0000 N   0  0
   -1.3039   -3.7494    0.0000 C   0  0
   -1.3092   -5.2494    0.0000 C   0  0
   -2.6108   -5.9949    0.0000 C   0  0
   -3.9072   -5.2404    0.0000 C   0  0
   -3.9020   -3.7404    0.0000 C   0  0
   -2.6004   -2.9949    0.0000 C   0  0
   -5.1992   -2.9856    0.0000 S   0  0
   -5.1935   -1.4856    0.0000 O   0  0
   -6.4953   -2.2305    0.0000 O   0  0
   -6.5020   -3.7306    0.0000 N   0  0
   -7.7992   -2.9757    0.0000 C   0  0
   -9.1013   -3.7204    0.0000 C   0  0
   -7.7935   -1.4758    0.0000 C   0  0
   -9.0952   -2.2206    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 12  1  0
 10 18  1  0
 18 19  2  0
 19  7  1  0
  5 20  1  0
 20 21  2  0
 21  2  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 27 29  1  0
 29 30  2  0
 29 31  2  0
 29 32  1  0
 32 33  1  0
 33 34  1  0
 33 35  1  0
 33 36  1  0
M  END
> <name>
UTKinase_V5

> <id>
29020

> <plate>
Kinase v5-3

> <well>
J16

> <supplier_cmpd_name>
TG-46

> <ctcr_id>
5159

> <supplier_cmpd_id>
SY-TG-46

> <smiles>
Cc1cnc(Nc2ccc(CN3CCOCC3)cc2)nc1Nc4cccc(c4)[S](=O)(=O)NC(C)(C)C

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{G4,936091-15-5,936091155,TG-46,TG46,SCHEMBL264717,DTXSID40587365,SYN1106,BCP28052,"TG-46; TG 46","TG46; TG 46",ZINC72232829,AKOS027420924,EX-8668,EX8668,NCGC00345846-01,NCGC0034584601,NCGC00345846-02
,NCGC0034584602,AS-16250,AS16250,J-523771,J523771,SY-TG-46}

> <pdid>
PD132032

> <targets>
{JAK2}

> <classes>
{}

> <pubchem_cids>
{16722834}

$$$$
UTKinase_V5
  SciTegic11012413002D

 16 18  0  0  0  0            999 V2000
    2.5951   -3.0031    0.0000 C   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.7248   -1.2135    0.0000 N   0  0
   -3.6065    0.0000    0.0000 C   0  0
   -5.0972    0.1560    0.0000 C   0  0
   -5.9786   -1.0577    0.0000 C   0  0
   -5.7073    1.5264    0.0000 N   0  0
   -4.8257    2.7399    0.0000 C   0  0
   -3.3339    2.5831    0.0000 C   0  0
   -2.7248    1.2135    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15  6  1  0
 15  9  1  0
  7 16  2  0
 16  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
29024

> <plate>
Kinase v5-3

> <well>
L10

> <supplier_cmpd_name>
Harmine hydrochloride

> <ctcr_id>
1401

> <supplier_cmpd_id>
S3817

> <smiles>
COc1ccc2c([nH]c3c(C)nccc23)c1

> <pd_targets>
{HTR2C,HTR6,ADRA2A,ALDH1A1,HPGD,CYP1A2,CLK1,DYRK1A,CCNT1,CDK9,NISCH,DYRK2,DYRK3,ACHE,DYRK4,CSNK1D,KDM4E,CCNA1,CCNA2,CDK2,MAOA,HSD17B10,CYP2D6,ADRA2B,ADRA2C,DYRK1B,HTR2A,HASPIN,RORC,CYP3A4,CSNK1E,PIM3,
SLC6A2,CDK5,CDK5R1,GSK3-BETA,GSK3A,CLK4,KLK7,CCNB1,CCNB2,CCNB3,CDK1,HTR7,CLK2,HIF1A,ABCG2}

> <pathway_gtopdb>
{"Membrane receptor",Enzyme,"Other cytosolic protein","Epigenetic regulator","Transcription factor",Transporter,"Family A G protein-coupled receptor",Oxidoreductase,"Cytochrome P450",Kinase,Hydrolase,
Eraser,"Nuclear receptor","Electrochemical transporter",Protease,"Primary active transporter","Small molecule receptor (family A GPCR)","Cytochrome P450 family 1","Protein Kinase","Lysine demethylase"
,"Cytochrome P450 family 2","Nuclear hormone receptor subfamily 1","Cytochrome P450 family 3","SLC superfamily of solute carriers","Serine protease","Cysteine protease","ATP-binding cassette","Monoami
ne receptor","Cytochrome P450 family 1A","CMGC protein kinase group","CK1 protein kinase group","Jumonji domain-containing","Cytochrome P450 family 2D","Other protein kinase group","Nuclear hormone re
ceptor subfamily 1 group F","Cytochrome P450 family 3A","CAMK protein kinase group","SLC06 neurotransmitter transporter family","Serine protease PA clan","Cysteine protease CA clan","ABCG subfamily","
Serotonin receptor","Adrenergic receptor","Cytochrome P450 1A1","CMGC protein kinase CLK family","CMGC protein kinase DYRK family","CMGC protein kinase CDK family","CK1 protein kinase CK1 family","Cyt
ochrome P450 2D6","Other protein kinase Haspin family","Nuclear hormone receptor subfamily 1 group F member 3","Cytochrome P450 3A4","CAMK protein kinase PIM family","CMGC protein kinase GSK family","
Serine protease S1A subfamily","Cysteine protease C1A family","CMGC protein kinase Dyrk1 subfamily","CMGC protein kinase CDK9 subfamily","CMGC protein kinase Dyrk2 subfamily","CMGC protein kinase CDC2
 subfamily"}

> <pathway_chembl>
{Receptors,Enzymes,Transporters,"G protein-coupled receptors","Eicosanoid turnover","Cytochrome P450","Kinases (EC 2.7.x.x)","Acetylcholine turnover","Chromatin modifying enzymes","Catecholamine turno
ver","Catalytic receptors","Nuclear hormone receptors","SLC superfamily of solute carriers","Peptidases and proteinases","ATP-binding cassette transporter family","5-Hydroxytryptamine receptors",Adren
oceptors,"Prostaglandin synthases","CYP1 family","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CK1: Casein kinase 1","1.14.11.- Histone demethylases","CYP2 family: drug metabolising subset","Recept
or kinases","1F. Retinoic acid-related orphans","CYP3 family","CAMK: Calcium/calmodulin-dependent protein kinases","SLC6 neurotransmitter transporter family","PA: Serine (S) Peptidases","ABCG subfamil
y","CLK family","Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family","Casein kinase 1 (CK1) family","Other protein kinases","PIM family","Monoamine transporter subfamily","S1
: Chymotrypsin","Dyrk1 subfamily","Dyrk2 subfamily","Haspin family"}

> <pathway_reactome>
{"Signal Transduction",Disease,Metabolism,"Cell Cycle","Gene expression (Transcription)","Extracellular matrix organization","Cellular responses to external stimuli","Signaling by GPCR","Infectious di
sease","Biological oxidations","Metabolism of lipids",Mitotic,"RNA Polymerase II Transcription","Metabolism of amino acids and derivatives","Disorders of transmembrane transporters","Degradation of th
e extracellular matrix","Cellular responses to stress","Abacavir transport and metabolism","GPCR ligand binding","Leishmania infection","Phase I - Functionalization of compounds","Biosynthesis of spec
ialized proresolving mediators (SPMs)","Mitotic G1 phase and G1/S transition","Generic Transcription Pathway","Phospholipid metabolism","Mitotic G2-G2/M phases","Branched-chain amino acid catabolism",
"SLC transporter disorders","Cellular response to hypoxia","Abacavir transmembrane transport","Class A/1 (Rhodopsin-like receptors)","Leishmania parasite growth and survival","Ethanol oxidation","Bios
ynthesis of DHA-derived SPMs","Cytochrome P450 - arranged by substrate type","G0 and Early G1","Transcriptional Regulation by TP53","Glycerophospholipid biosynthesis","G2/M Transition","Amine Oxidase 
reactions","Transcriptional regulation by RUNX3","Defective SLC6A2 causes orthostatic intolerance (OI)","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Amine ligand-binding
 receptors","Anti-inflammatory response favouring Leishmania parasite infection","Biosynthesis of D-series resolvins",Xenobiotics,"Regulation of TP53 Activity","Synthesis of PC","Centrosome maturation
","Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB","RUNX3 Regulates Immune Response and Cell Migration","Biosynthesis of maresins","Serotonin receptors","ADORA2B mediated ant
i-inflammatory cytokines production",Adrenoceptors,"Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Regulation of TP53 Activity through Phosphorylation","Loss of proteins required f
or interphase microtubule organization from the centrosome","CYP2E1 reactions","Biosynthesis of maresin-like SPMs","Loss of Nlp from mitotic centrosomes"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{HARMINE,442-51-3,442513,"7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole","7Methoxy1methyl9Hpyrido(3,4b)indole",Banisterine,Telepathine,Leucoharmine,Yageine,Yajeine,Harmin,"9H-Pyrido(3,4-b)indole, 7-methox
y-1-methyl-","9HPyrido(3,4b)indole, 7methoxy1methyl",7-Methoxy-1-methyl-9H-beta-carboline,7Methoxy1methyl9Hbetacarboline,Banisterin,Telepathin,Yagein,1-Methyl-7-met,1Methyl7met,T1711,T2811,1500867,Har
mine,"Harmine hydrochloride"}

> <pdid>
PD001545

> <targets>
{DYRK1A,MAO,"5-HT Receptor",DYRK}

> <classes>
{CNS stimulant,antiparkinsonian,GPCR/G Protein,Neuronal Signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{5280953}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 34  0  0  0  0            999 V2000
    5.1278   -8.9351    0.0000 C   0  0
    4.3823   -7.6335    0.0000 C   0  0
    4.9972   -6.2653    0.0000 C   0  0
    3.8864   -5.2585    0.0000 C   0  0
    2.5847   -6.0040    0.0000 C   0  0
    2.8911   -7.4715    0.0000 N   0  0
    1.2883   -5.2495    0.0000 C   0  0
    1.2935   -3.7495    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    3.8915   -3.7585    0.0000 C   0  0
    5.1932   -3.0130    0.0000 F   0  0
    2.5973   -1.5031    0.0000 O   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0
    1.2990    3.7500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    1.2959    5.2508    0.0000 O   0  0
   -0.0049    5.9994    0.0000 C   0  0
   -0.0080    7.5002    0.0000 C   0  0
    1.3768    7.4363    0.0000 C   0  0
    0.6243    8.7339    0.0000 C   0  0
   -1.3084    8.2479    0.0000 N   0  0
    3.8994    3.7478    0.0000 O   0  0
    5.1973    2.9959    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  2  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10  4  1  0
 10 11  1  0
  9 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 14  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 13  1  0
 17 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 25  1  0
 25 28  1  0
 16 29  1  0
 29 30  1  0
M  END
> <name>
UTKinase_V5

> <id>
29025

> <plate>
Kinase v5-3

> <well>
L12

> <supplier_cmpd_name>
Anlotinib

> <ctcr_id>
11533

> <supplier_cmpd_id>
S8726

> <smiles>
Cc1cc2c([nH]1)ccc(c2F)Oc1c2cc(c(cc2ncc1)OCC1(CC1)N)OC

> <pd_targets>
{FLT4,FLT1,FGFR1,KDR}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase VEGFR family","Tyrosine protein kinase FGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family","Type V RTKs: FGF
 (fibroblast growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Signaling by Receptor Tyrosine Kinases","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by VEGF","Signaling by FGFR in dis
ease","VEGF ligand-receptor interactions","Signaling by FGFR1 in disease","VEGFA-VEGFR2 Pathway","VEGF binds to VEGFR leading to receptor dimerization","FGFR1 mutant receptor activation","VEGFR2 media
ted cell proliferation","Signaling by activated point mutants of FGFR1"}

> <broad_targets>
{KDR,PDGFRB}

> <broad_moa>
{"PDGFR tyrosine kinase receptor inhibitor","VEGFR inhibitor"}

> <synonyms>
{4678B,Q27279141,Anlotinib,1058156-90-3,1058156903,"Anlotinib free base",AL3818,UNII-GKF8S4C432,UNIIGKF8S4C432,GKF8S4C432,"1058156-90-3 (free base)","1058156903 (free base)",AL-3818,catequentinib,GTPL
9601,SCHEMBL2063386,CHEMBL4303201,BCP24991,EX-A2427,EXA2427,ZINC117924202,"AL 3818",CS-5396,CS5396,DB11885,SB197,T4094,T3441,"Anlotinib Dihydrochloride"}

> <pdid>
PD056639

> <targets>
{VEGFR2,EGFR}

> <classes>
{Angiogenesis,"JAK/STAT signaling","Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{25017411}

$$$$
UTKinase_V5
  SciTegic11012413002D

 30 31  0  0  0  0            999 V2000
    7.6082   -1.1203    0.0000 H   0  3
    5.1082   -1.1203    0.0000 Cl  0  5
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0049   -5.9994    0.0000 C   0  0
    0.0102   -7.4994    0.0000 C   0  0
    1.3118   -8.2449    0.0000 C   0  0
    2.6082   -7.4904    0.0000 O   0  0
    2.6030   -5.9904    0.0000 C   0  0
    1.3014   -5.2449    0.0000 C   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 O   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -2.6005    2.9949    0.0000 C   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -3.9073    5.2404    0.0000 C   0  0
   -5.2089    5.9859    0.0000 F   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -0.0128    6.0039    0.0000 F   0  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 14  1  0
 12 20  1  0
 20 21  2  0
 21  4  1  0
 21  9  1  0
  7 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 26 28  1  0
 28 29  2  0
 29 23  1  0
 29 30  1  0
M  CHG  2   1   1   2  -1
M  END
> <name>
UTKinase_V5

> <id>
29027

> <plate>
Kinase v5-3

> <well>
L16

> <supplier_cmpd_name>
R1487

> <ctcr_id>
1000

> <supplier_cmpd_id>
SY-R1487

> <smiles>
[H+].[Cl-].CN1C(=O)C(=Cc2cnc(NC3CCOCC3)nc12)Oc4ccc(F)cc4F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{}

> <broad_moa>
{"p38 MAPK inhibitor"}

> <synonyms>
{"1487 (SYR1487",449808-64-4,449808644,"R1487 (Hydrochloride)","R1487 HCl",R1487,"R1487 Hydrochloride","R-1487 Hydrochloride",C19H18F2N4O3.HCl,CHEMBL1766582,SCHEMBL20582726,DTXSID60712354,EX-A670,EXA6
70,SYN1101,BCP01963,MFCD18711690,AKOS030622859,CS-5860,CS5860,QC-6149,QC6149,HY-1497,HY1497,SY-R1487,"R1487  (SY-R1487)"}

> <pdid>

> <targets>
{MAPK(p38MAP),"p38 MAPK",Autophagy}

> <classes>
{Autophagy,MAPK/ERK Pathway}

> <pubchem_cids>
{54580957}

$$$$
UTKinase_V5
  SciTegic11012413002D

 33 36  0  0  0  0            999 V2000
    3.8983   -0.7459    0.0000 C   0  0
    2.6003   -1.4977    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 O   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2959   -5.2508    0.0000 N   0  0
    0.0042   -5.9990    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000    3.0008    0.0000 C   0  0
   -1.3002    3.7488    0.0000 C   0  0
   -1.3026    5.2488    0.0000 C   0  0
   -2.6051    5.9945    0.0000 N   0  0
   -3.9026    5.2402    0.0000 C   0  0
   -3.8976    3.7402    0.0000 O   0  0
   -5.2051    5.9858    0.0000 N   0  0
   -6.5026    5.2315    0.0000 C   0  0
   -7.8054    5.9749    0.0000 C   0  0
   -9.1007    5.2183    0.0000 C   0  0
   -9.0931    3.7183    0.0000 C   0  0
   -7.7903    2.9749    0.0000 C   0  0
   -6.4951    3.7315    0.0000 C   0  0
   -0.0048    6.0009    0.0000 C   0  0
   -0.0072    7.5009    0.0000 F   0  0
    1.2954    5.2529    0.0000 C   0  0
    1.2978    3.7529    0.0000 C   0  0
    2.5981    3.0050    0.0000 Br  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  3
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 11 14  1  0
 14 15  2  0
 15  3  1  0
 15  8  1  0
  6 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
 18 29  2  0
 29 30  1  0
 29 31  1  0
 31 32  2  0
 32 16  1  0
 32 33  1  0
M  END
> <name>
UTKinase_V5

> <id>
29032

> <plate>
Kinase v5-3

> <well>
N12

> <supplier_cmpd_name>
Ripretinib

> <ctcr_id>
14945

> <supplier_cmpd_id>
S8757

> <smiles>
CCN1C(=O)C(=Cc2cnc(NC)cc12)c3cc(NC(=O)Nc4ccccc4)c(F)cc3Br

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{DCC-2618,HY-112306,Ripretinib,Ripretinib}

> <pdid>
PD078698

> <targets>
{Apoptosis,c-Kit,FLT3,PDGFR,VEGFR}

> <classes>
{Apoptosis,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 40 44  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5987    1.5004    0.0000 C   0  0
   -2.6012    3.0004    0.0000 C   0  0
   -3.9015    3.7484    0.0000 C   0  0
   -5.1993    2.9963    0.0000 N   0  0
   -5.1969    1.4963    0.0000 C   0  0
   -3.8967    0.7484    0.0000 C   0  0
   -6.5002    3.7446    0.0000 C   0  0
   -6.5050    5.2446    0.0000 C   0  0
   -7.8065    5.9905    0.0000 C   0  0
   -9.1031    5.2364    0.0000 C   0  0
   -9.0983    3.7364    0.0000 C   0  0
   -7.7969    2.9905    0.0000 C   0  0
  -10.4068    5.9800    0.0000 N   0  0
  -11.7031    5.2236    0.0000 C   0  0
  -13.0071    5.9649    0.0000 N   0  0
  -14.3012    5.2063    0.0000 C   0  0
  -14.2912    3.7063    0.0000 C   0  0
  -12.9872    2.9650    0.0000 C   0  0
  -11.6932    3.7236    0.0000 N   0  0
  -12.9742    1.4642    0.0000 N   0  0
  -11.6684    0.7243    0.0000 C   0  0
  -10.3769    1.4873    0.0000 C   0  0
   -9.0704    0.7505    0.0000 C   0  0
   -9.0552   -0.7495    0.0000 C   0  0
  -10.3466   -1.5125    0.0000 C   0  0
  -11.6532   -0.7757    0.0000 C   0  0
  -12.9453   -1.5392    0.0000 P   0  0
  -12.9310   -3.0391    0.0000 O   0  0
  -14.2516   -0.8020    0.0000 C   0  0
  -14.2370   -2.3017    0.0000 C   0  0
  -15.5852    2.9477    0.0000 Cl  0  0
   -7.8081    7.4913    0.0000 O   0  0
   -6.5104    8.2436    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13  8  1  0
 11 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 14  1  0
 17 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
 25 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32 33  2  0
 33 28  1  0
 33 34  1  0
 34 35  2  0
 34 36  1  0
 34 37  1  0
 24 38  1  0
 16 39  1  0
 39 40  1  0
M  END
> <name>
UTKinase_V5

> <id>
29033

> <plate>
Kinase v5-3

> <well>
N14

> <supplier_cmpd_name>
Brigatinib

> <ctcr_id>
11338

> <supplier_cmpd_id>
S8229

> <smiles>
CN1CCN(CC1)C1CCN(CC1)c1cc(c(cc1)Nc1ncc(c(n1)Nc1ccccc1P(=O)(C)C)Cl)OC

> <pd_targets>
{EGFR,ROS1,INSR,FLT3,IGF1R,ALK,ABL1,MET,ERBB4,ERBB2}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","TKL protein kinase group","Tyrosine protein kinase EGFR family","Tyrosine protein kinase Sev family","Tyrosine protein kinase InsR family","T
yrosine protein kinase PDGFR family","TKL protein kinase STKR family","Tyrosine protein kinase Abl family","Tyrosine protein kinase Met family","TKL protein kinase STKR Type 1 subfamily"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Non-receptor tyrosine kinases (nRTKs)","Type I RTKs: ErbB (epidermal growth factor) recept
or family","Type XVII RTKs: ROS receptors","Type II RTKs: Insulin receptor family","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family","Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor famil
y","Abl family","Type X RTKs: HGF (hepatocyte growth factor) receptor family"}

> <pathway_reactome>
{"Signal Transduction",Disease,"Developmental Biology","Neuronal System","Signaling by GPCR","Intracellular signaling by second messengers","Signaling by Receptor Tyrosine Kinases","Infectious disease
","Nervous system development","Transmission across Chemical Synapses","GPCR downstream signalling","PIP3 activates AKT signaling","Signaling by Insulin receptor","Signaling by Type 1 Insulin-like Gro
wth Factor 1 Receptor (IGF1R)","Leishmania infection","Axon guidance","Neurotransmitter receptors and postsynaptic signal transmission","G alpha (q) signalling events","Negative regulation of the PI3K
/AKT network","Insulin receptor signalling cascade","IGF1R signaling cascade","Parasite infection","Semaphorin interactions","Activation of NMDA receptors and postsynaptic events","Gastrin-CREB signal
ling pathway via PKC and MAPK",PI5P,"PP2A and IER3 Regulate PI3K/AKT Signaling","IRS-mediated signalling","IRS-related events triggered by IGF1R","Leishmania phagocytosis","Sema4D in semaphorin signal
ing","Post NMDA receptor activation events","EGFR Transactivation by Gastrin","PI3K Cascade","FCGR3A-mediated phagocytosis","Sema4D mediated inhibition of cell attachment and migration","Long-term pot
entiation","Sema4D induced cell migration and growth-cone collapse"}

> <broad_targets>
{ALK,EGFR}

> <broad_moa>
{"ALK tyrosine kinase receptor inhibitor","EGFR inhibitor"}

> <synonyms>
{"Brigatinib (USAN:INN)","Brigatinib; AP26113",CHEMBL3545311,SCHEMBL11916361,EX-A775,EXA775,AMY10294,BCP17214,BDBM50185140,MFCD29472221,NSC784728,NSC787457,AKOS030257612,ZINC148723177,CS-4278,CS4278,D
B12267,NSC-784728,NSC-787457,SB40412,NCGC00483924-01,NCGC0048392401,AC-299,AC299,T3621,Brigatinib}

> <pdid>
PD012803

> <targets>
{ALK,ROS1,IGF-1R,FLT3,"EGFR (C797S/del19)"}

> <classes>
{Angiogenesis,Immunology/Inflammation,Tyrosine Kinase/Adaptors,JAK/STAT signaling,Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
{68165256}

$$$$
UTKinase_V5
  SciTegic11012413002D

 26 28  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -0.0031    3.0008    0.0000 N   0  0
   -1.3039    3.7494    0.0000 C   0  0
   -1.3092    5.2494    0.0000 C   0  0
   -2.6108    5.9949    0.0000 C   0  0
   -2.6191    7.4957    0.0000 N   0  0
   -3.9225    8.2398    0.0000 C   0  0
   -5.2176    7.4830    0.0000 O   0  0
   -3.9308    9.7406    0.0000 C   0  0
   -5.2325   10.4861    0.0000 C   0  0
   -6.5289    9.7316    0.0000 Cl  0  0
   -5.2377   11.9861    0.0000 C   0  0
   -3.9413   12.7406    0.0000 C   0  0
   -2.6396   11.9952    0.0000 C   0  0
   -2.6344   10.4952    0.0000 C   0  0
   -1.3327    9.7498    0.0000 Cl  0  0
   -3.9073    5.2404    0.0000 C   0  0
   -3.9021    3.7404    0.0000 C   0  0
   -2.6005    2.9949    0.0000 N   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 N   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 12  1  0
 18 19  1  0
  8 20  2  0
 20 21  1  0
 21 22  2  0
 22  6  1  0
  4 23  2  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 26  2  1  0
M  END
> <name>
UTKinase_V5

> <id>
29034

> <plate>
Kinase v5-3

> <well>
N16

> <supplier_cmpd_name>
RO495

> <ctcr_id>
4371

> <supplier_cmpd_id>
SY-RO495

> <smiles>
Cc1cc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)ccn2)nc(N)n1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{RO495,1258296-60-4,1258296604,C17H14Cl2N6O,SCHEMBL3514972,CHEMBL2142114,SYN1128,HMS3741O19,BCP21626,EX-A1857,EXA1857,ZINC95567045,"RO-495;RO 495","RO495;RO 495",NCGC00263200-01,NCGC0026320001,NCGC002
63200-02,NCGC0026320002,AS-16267,AS16267,DB-109762,DB109762,SY-RO495}

> <pdid>
PD144412

> <targets>
{TYK2}

> <classes>
{}

> <pubchem_cids>
{57519505}

$$$$
UTKinase_V5
  SciTegic11012413002D

 14 16  0  0  0  0            999 V2000
   -0.6923   -4.0811    0.0000 N   0  0
    0.3114   -2.9665    0.0000 C   0  0
    1.8032   -3.1233    0.0000 N   0  0
    2.4133   -1.7530    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
   -1.2991    3.7500    0.0000 C   0  0
   -2.5981    3.0000    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
 12 13  1  0
 13 14  2  0
 14  2  1  0
 14  5  1  0
M  END
> <name>
UTKinase_V5

> <id>
29035

> <plate>
Kinase v5-3

> <well>
N18

> <supplier_cmpd_name>
NSC 693868

> <ctcr_id>
6310

> <supplier_cmpd_id>
1937

> <smiles>
Nc1n[nH]c2nc3ccccc3nc12

> <pd_targets>
{GSK3B,CYP2C9,MAPT,RORC,KMT2A,MEN1,LEF,EIF2AK2,CYP2C19,CCNA2,CDK2,CDK1,CYP3A4,CYP1A2,CDK5,CDK5R1,IMPA1,TP53,CCNT1,CDK9,CCNE1,CCNB1}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Transcription factor","Epigenetic regulator",Kinase,"Cytochrome P450","Nuclear receptor",Reader,Protease,Hydrolase,"Protein Kinase","Cytochrome P450 family 2","Nucle
ar hormone receptor subfamily 1",Bromodomain,"Metallo protease","Cytochrome P450 family 3","Cytochrome P450 family 1","CMGC protein kinase group","Cytochrome P450 family 2C","Nuclear hormone receptor 
subfamily 1 group F","Metallo protease MAE clan","Other protein kinase group","Cytochrome P450 family 3A","Cytochrome P450 family 1A","CMGC protein kinase GSK family","Cytochrome P450 2C9","Nuclear ho
rmone receptor subfamily 1 group F member 3","Metallo protease M34 family","Other protein kinase PEK family","Cytochrome P450 2C19","CMGC protein kinase CDK family","Cytochrome P450 3A4","Cytochrome P
450 1A1","Other protein kinase PKR","CMGC protein kinase CDC2 subfamily","CMGC protein kinase CDK5 subfamily","CMGC protein kinase CDK9 subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Cytochrome P450","Nuclear hormone receptors","Catalytic receptors","Inositol phosphate turnover","CMGC: Containing CDK",MAPK,GSK3,"CLK families","CYP2 family
: drug metabolising subset","1F. Retinoic acid-related orphans","Receptor kinases","CYP3 family","CYP1 family","Inositol monophosphatase","Glycogen synthase kinase (GSK) family","Other protein kinases
","Cyclin-dependent kinase (CDK) family","GSK subfamily","PEK family","CDK1 subfamily","CDK5 subfamily","Other PEK family kinases"}

> <pathway_reactome>
{Disease,Metabolism,"Neuronal System","Gene expression (Transcription)","Cell Cycle","Infectious disease","Biological oxidations","Transmission across Chemical Synapses","RNA Polymerase II Transcripti
on",Mitotic,"Metabolism of lipids","Inositol phosphate metabolism","Cell Cycle Checkpoints","SARS-CoV Infections","Phase I - Functionalization of compounds","Neurotransmitter receptors and postsynapti
c signal transmission","Generic Transcription Pathway","Uptake and actions of bacterial toxins","Influenza Infection","Regulation of mitotic cell cycle","Biosynthesis of specialized proresolving media
tors (SPMs)","Synthesis of IP2",IP,"and Ins in the cytosol","G1/S DNA Damage Checkpoints","SARS-CoV-1 Infection","Cytochrome P450 - arranged by substrate type","Activation of NMDA receptors and postsy
naptic events","Transcriptional regulation by RUNX3","Uptake and function of anthrax toxins","NS1 Mediated Effects on Host Pathways","APC/C-mediated degradation of cell cycle proteins","Biosynthesis o
f DHA-derived SPMs","p53-Dependent G1/S DNA damage checkpoint","Transcriptional Regulation by TP53","SARS-CoV-1 Genome Replication and Transcription",Xenobiotics,"Post NMDA receptor activation events"
,"RUNX3 Regulates Immune Response and Cell Migration","Inhibition of PKR","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","Biosynthesis of maresins","p53-Dependent G1 DN
A Damage Response","Regulation of TP53 Activity","Replication of the SARS-CoV-1 genome","CYP2E1 reactions","Activation of AMPK downstream of NMDARs","APC/C:Cdc20 mediated degradation of mitotic protei
ns","Biosynthesis of maresin-like SPMs","Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2","Stabilization of p53","Regulation of TP53 Activity through Phosphorylation","APC:Cdc20 media
ted degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","Autodegradation of the E3 ubiquitin ligase COP1","Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{40254-90-8,40254908,"Cdk1/5 Inhibitor","1H-Pyrazolo(3,4-b)quinoxalin-3-amine","1HPyrazolo(3,4b)quinoxalin3amine","3-Amino-1H-pyrazolo(3,4-b)quinoxaline","3Amino1Hpyrazolo(3,4b)quinoxaline",Quinoxalin
e1,"2H-pyrazolo(4,3-b)quinoxalin-3-amine","2Hpyrazolo(4,3b)quinoxalin3amine","NSC 693868","2H-PYRAZOLO(3,4-B)QUINOXALIN-3-AMINE","2HPYRAZOLO(3,4B)QUINOXALIN3AMINE",NSC693868,56984-56-6,56984566,quinox
a,"EMD 217720",1937,217720}

> <pdid>
PD017396

> <targets>
{cdk}

> <classes>
{}

> <pubchem_cids>
{438981}

$$$$
UTKinase_V5
  SciTegic11012413002D

 21 23  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
   -2.4133    1.7530    0.0000 N   0  0
   -1.8032    3.1233    0.0000 C   0  0
   -2.5497    4.4223    0.0000 N   0  0
   -1.7974    5.7210    0.0000 C   0  0
   -0.2974    5.7184    0.0000 O   0  0
   -2.5451    7.0223    0.0000 C   0  0
   -1.7928    8.3210    0.0000 C   0  0
   -2.5383    9.6227    0.0000 C   0  0
   -1.7838   10.9191    0.0000 C   0  0
   -0.2838   10.9139    0.0000 C   0  0
    0.4617    9.6123    0.0000 C   0  0
   -0.2928    8.3159    0.0000 C   0  0
   -0.3115    2.9665    0.0000 S   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  5  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 10 21  1  0
 21  4  1  0
M  END
> <name>
UTKinase_V5

> <id>
29036

> <plate>
Kinase v5-3

> <well>
N20

> <supplier_cmpd_name>
LH 846

> <ctcr_id>
13610

> <supplier_cmpd_id>
4896

> <smiles>
Cc1cc2c(cc1Cl)nc(NC(=O)Cc1ccccc1)s2

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
{CSNK1D}

> <broad_moa>
{"casein kinase inhibitor"}

> <synonyms>
{H84,639052-78-1,639052781,LH846,LH-846,"LH 846","N-(5-chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide","N(5chloro6methyl1,3benzothiazol2yl)2phenylacetamide",N-(5-Chloro-6-methyl-2-benzothiaz
olyl)benzeneacetamide,N(5Chloro6methyl2benzothiazolyl)benzeneacetamide,"Benzeneacetamide, N-(5-chloro-6-methyl-2-benzothiazolyl)-","Benzeneacetamide, N(5chloro6methyl2benzothiazolyl)",N-(5-chloro-6-me
thylbenzo(d)thiazol,N(5chloro6methylbenzo(d)thiazol,T1877}

> <pdid>
PD012543

> <targets>
{"CK 1",CK1}

> <classes>
{Metabolism,"Stem Cells"}

> <pubchem_cids>
{851474}

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 42  0  0  0  0            999 V2000
    3.9015    0.7475    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    5.1969   -1.5045    0.0000 C   0  0
    5.1945   -3.0045    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    2.5965   -3.0004    0.0000 C   0  0
    2.5987   -1.5004    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 N   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -2.5981    1.5000    0.0000 C   0  0
   -3.8971    0.7500    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -2.5981   -3.0000    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 O   0  0
    2.5972    1.5031    0.0000 C   0  0
    2.5951    3.0039    0.0000 N   0  0
    1.3787    3.8597    0.0000 N   0  0
    1.8375    5.2879    0.0000 C   0  0
    0.9515    6.4991    0.0000 C   0  0
   -0.5427    6.4495    0.0000 C   0  0
   -1.3347    7.7234    0.0000 C   0  0
   -0.6274    9.0462    0.0000 C   0  0
    0.8718    9.0951    0.0000 C   0  0
    1.5790   10.4179    0.0000 O   0  0
    1.6637    7.8212    0.0000 C   0  0
    3.3367    5.2926    0.0000 C   0  0
    4.3367    6.4106    0.0000 C   0  0
    3.8684    7.8357    0.0000 N   0  0
    5.8050    6.1036    0.0000 N   0  0
    6.2732    4.6786    0.0000 C   0  0
    5.2732    3.5606    0.0000 N   0  0
    3.8050    3.8675    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 17 11  1  0
 17 18  1  0
 18  8  1  0
 18 19  2  0
  9 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 25 26  1  0
 26 27  2  0
 27 28  1  0
 28 29  1  0
 28 30  2  0
 30 24  1  0
 23 31  1  0
 31 32  2  0
 32 33  1  0
 32 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 21  1  0
 37 31  1  0
M  END
> <name>
UTKinase_V5

> <id>
29037

> <plate>
Kinase v5-3

> <well>
N22

> <supplier_cmpd_name>
PIK294

> <ctcr_id>
6151

> <supplier_cmpd_id>
SY-PIK294

> <smiles>
Cc1ccccc1N2C(=Nc3cccc(C)c3C2=O)Cn4nc(c5cccc(O)c5)c6c(N)ncnc46

> <pd_targets>
{PIK3CA,PIK3CD,PIK3CB,ABL1,PIK3CG,PRKDC,SRC,MTOR}

> <pathway_gtopdb>
{Enzyme,Transferase,Kinase,"Protein Kinase","TK protein kinase group","Atypical protein kinase group","Tyrosine protein kinase Abl family","Atypical protein kinase PIKK family","Tyrosine protein kinas
e Src family","Atypical protein kinase FRAP subfamily"}

> <pathway_chembl>
{Enzymes,Receptors,"Kinases (EC 2.7.x.x)","Catalytic receptors","Lipid modifying kinases","Receptor kinases",Atypical,Phosphatidylinositol-4,"5-bisphosphate 3-kinase family","TK: Tyrosine kinase","Pho
sphatidyl inositol 3' kinase-related kinases (PIKK) family","Non-receptor tyrosine kinases (nRTKs)","Other PIKK family kinases","FRAP subfamily","Abl family","Src family"}

> <pathway_reactome>
{Disease,"Immune System","Signal Transduction",Metabolism,"Gene expression (Transcription)","Diseases of signal transduction by growth factor receptors and second messengers","Cytokine Signaling in Im
mune system","Signaling by Receptor Tyrosine Kinases","Infectious disease","Metabolism of lipids","Innate Immune System","RNA Polymerase II Transcription","Signaling by FGFR in disease","Signaling by 
Interleukins","Signaling by Insulin receptor","Leishmania infection","Phospholipid metabolism","Cytosolic sensors of pathogen-associated DNA","Signaling by NTRKs","Generic Transcription Pathway","Sign
aling by FGFR1 in disease",Interleukin-3,"Interleukin-5 and GM-CSF signaling","Insulin receptor signalling cascade","Parasite infection","PI Metabolism","STING mediated induction of host immune respon
ses","Signaling by NTRK1 (TRKA)","Transcriptional Regulation by TP53","FGFR1 mutant receptor activation","Interleukin receptor SHC signaling","IRS-mediated signalling","Leishmania phagocytosis","Synth
esis of PIPs at the plasma membrane","IRF3-mediated induction of type I IFN","Signalling to ERKs","Regulation of TP53 Activity","Signaling by cytosolic FGFR1 fusion mutants","PI3K Cascade","FCGR3A-med
iated phagocytosis","Signalling to RAS","Regulation of TP53 Expression and Degradation","p38MAPK events","Regulation of TP53 Degradation"}

> <broad_targets>
{PIK3CB,PIK3CD,PIK3CG}

> <broad_moa>
{"PI3K inhibitor"}

> <synonyms>
{IK29,PIK-294,PIK294,900185-02-6,900185026,"PIK 294",C28H23N7O2,cc-610,cc610,MLS006010993,SCHEMBL1952680,CHEMBL1241767,BDBM36411,AOB6611,DTXSID20648004,SYN1098,HMS3244E13,HMS3244E14,HMS3244F13,HMS3655
P12,BCP01970,EX-A2568,EXA2568,s2227,ZINC62260316,AKOS026750411,CCG-269607,CCG269607,CS-,CS,T2297,SY-PIK294,S2227}

> <pdid>
PD010815

> <targets>
{delta,PI3K,PIK3}

> <classes>
{PI3K/Akt/mTOR}

> <pubchem_cids>
{24905149}

$$$$
UTKinase_V5
  SciTegic11012413002D

 18 17  0  0  0  0            999 V2000
    7.6894   -3.0057    0.0000 Cl  0  0
    5.1873   -7.5109    0.0000 C   0  0
    5.1894   -6.0109    0.0000 C   0  0
    3.8912   -5.2578    0.0000 N   0  0
    2.5886   -6.0033    0.0000 C   0  0
    1.2919   -5.2492    0.0000 C   0  0
    3.8933   -3.7570    0.0000 C   0  0
    2.5951   -3.0039    0.0000 C   0  0
    1.2948   -3.7516    0.0000 O   0  0
    2.5973   -1.5031    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 C   0  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 11  1  0
 17 18  1  0
M  END
> <name>
UTKinase_V5

> <id>
29038

> <plate>
Kinase v5-3

> <well>
P10

> <supplier_cmpd_name>
Lidocaine hydrochloride

> <ctcr_id>
2126

> <supplier_cmpd_id>
S4667

> <smiles>
Cl.CCN(CC)CC(=O)Nc1c(C)cccc1C

> <pd_targets>
{SCN2A,AMPC,SCN1A,SCN3A,MAPK1,SCN9A,SCN5A,MAPT,LMNA,CHRM1,SCN4A,SCN10A,ALDH1A1,CYP3A4,GAA,BLM,SCN11A,SCN7A,SCN8A,EGFR}

> <pathway_gtopdb>
{"Ion channel",Enzyme,"Other cytosolic protein","Other nuclear protein","Membrane receptor","Voltage-gated ion channel",Hydrolase,Kinase,"Family A G protein-coupled receptor",Oxidoreductase,"Cytochrom
e P450","Voltage-gated sodium channel","Protein Kinase","Small molecule receptor (family A GPCR)","Cytochrome P450 family 3","CMGC protein kinase group","Monoamine receptor","Cytochrome P450 family 3A
","TK protein kinase group","CMGC protein kinase MAPK family","Acetylcholine receptor","Cytochrome P450 3A4","Tyrosine protein kinase EGFR family","CMGC protein kinase ERK1"}

> <pathway_chembl>
{"Ion channels",Enzymes,Receptors,"Voltage-gated ion channels","Kinases (EC 2.7.x.x)","G protein-coupled receptors","Cytochrome P450","3.2.1.- Glycosidases","Catalytic receptors","Voltage-gated sodium
 channels","CMGC: Containing CDK",MAPK,GSK3,"CLK families","Acetylcholine receptors (muscarinic)","CYP3 family","Receptor kinases","Mitogen-activated protein kinases (MAP kinases)","TK: Tyrosine kinas
e","ERK subfamily","Receptor tyrosine kinases (RTKs)","Type I RTKs: ErbB (epidermal growth factor) receptor family"}

> <pathway_reactome>
{"Developmental Biology","Immune System","Neuronal System","Cell Cycle","Signal Transduction",Metabolism,Disease,"DNA Repair","Nervous system development","Innate Immune System","Transmission across C
hemical Synapses",Mitotic,"Signaling by GPCR","Biological oxidations","Metabolism of lipids","Diseases of metabolism","DNA Double-Strand Break Repair","Axon guidance","Toll-like Receptor Cascades","Ne
urotransmitter receptors and postsynaptic signal transmission","M Phase","GPCR ligand binding","Phase I - Functionalization of compounds","Biosynthesis of specialized proresolving mediators (SPMs)","D
iseases of carbohydrate metabolism","Homology Directed Repair","GPCR downstream signalling","L1CAM interactions","Toll Like Receptor 5 (TLR5) Cascade","Activation of NMDA receptors and postsynaptic ev
ents","Mitotic Metaphase and Anaphase","Class A/1 (Rhodopsin-like receptors)","Ethanol oxidation","Biosynthesis of DHA-derived SPMs","Glycogen storage diseases","HDR through Homologous Recombination (
HRR) or Single Strand Annealing (SSA)","G alpha (q) signalling events","Interaction between L1 and Ankyrins","MyD88 cascade initiated on plasma membrane","Post NMDA receptor activation events","Mitoti
c Anaphase","Amine ligand-binding receptors","Biosynthesis of maresins","Glycogen storage disease type II (GAA)","HDR through Homologous Recombination (HRR)","Gastrin-CREB signalling pathway via PKC a
nd MAPK","MAP kinase activation","Activation of AMPK downstream of NMDARs","Nuclear Envelope (NE) Reassembly","Muscarinic acetylcholine receptors","Biosynthesis of maresin-like SPMs","Homologous DNA P
airing and Strand Exchange","EGFR Transactivation by Gastrin","MAPK targets/ Nuclear events mediated by MAP kinases","Initiation of Nuclear Envelope (NE) Reformation","Presynaptic phase of homologous 
DNA pairing and strand exchange","ERK/MAPK targets","ERKs are inactivated"}

> <broad_targets>
{EGFR,SCN10A,SCN5A,SCN9A}

> <broad_moa>
{"histamine receptor agonist"}

> <synonyms>
{Lidocaton,LIDOPEN,"Lidocaine hydrochloride anhydrous",CHEBI:50512,"2-Diethylamino-2',6'-acetoxylidide hydrochloride","2Diethylamino2',6'acetoxylidide hydrochloride","alpha-Diethylamino-2,6-acetoxylid
ine hydrochloride","alphaDiethylamino2,6acetoxylidine hydrochloride","Alphacaine N","Alphacaine SP",omega-Diethylamino-2,omegaDiethylamino2,6-dime,6dime,T1144L,T1144,1500689,Prestw-50,"Lidocaine Hydro
chloride hydrate","Lidocaine hydrochloride","LIDOCAINE HYDROCHLORIDE"}

> <pdid>
PD003120

> <targets>
{}

> <classes>
{"anesthetic (local)",antiarrhythmic}

> <pubchem_cids>
{49852294,6314,657223}

$$$$
UTKinase_V5
  SciTegic11012413002D

 39 44  0  0  0  0            999 V2000
    5.0503   -7.2216    0.0000 C   0  0
    3.6063   -6.8158    0.0000 O   0  0
    3.2346   -5.3617    0.0000 C   0  0
    1.7911   -4.9538    0.0000 C   0  0
    1.4226   -3.4998    0.0000 C   0  0
    2.4975   -2.4536    0.0000 C   0  0
    2.1312   -0.9982    0.0000 C   0  0
    3.1600    0.0000    0.0000 N   0  0
    2.7200    1.4900    0.0000 C   0  0
    4.2100    1.1700    0.0000 C   0  0
    4.6600   -0.2800    0.0000 C   0  0
    3.6100   -1.4000    0.0000 C   0  0
    2.1300   -1.0700    0.0000 N   0  0
    1.6600    0.3700    0.0000 C   0  0
    0.7534   -1.7821    0.0000 C   0  0
   -0.5117   -0.9762    0.0000 C   0  0
   -1.8422   -1.6688    0.0000 C   0  0
   -1.9077   -3.1673    0.0000 C   0  0
   -0.6427   -3.9733    0.0000 C   0  0
    0.6879   -3.2808    0.0000 N   0  0
   -3.2389   -3.8602    0.0000 C   0  0
   -3.3022   -5.3590    0.0000 C   0  0
   -4.6316   -6.0536    0.0000 C   0  0
   -4.6978   -7.5530    0.0000 O   0  0
   -6.0290   -8.2462    0.0000 C   0  0
   -6.0953   -9.7455    0.0000 C   0  0
   -4.8303  -10.5517    0.0000 C   0  0
   -6.1608  -11.2441    0.0000 C   0  0
   -7.4257  -10.4383    0.0000 O   0  0
   -5.8979   -5.2496    0.0000 C   0  0
   -5.8348   -3.7510    0.0000 N   0  0
   -6.9059   -2.7020    0.0000 N   0  0
   -6.2387   -1.3586    0.0000 C   0  0
   -4.7548   -1.5780    0.0000 C   0  0
   -3.7061   -0.5080    0.0000 C   0  0
   -2.6562    0.5633    0.0000 N   0  0
   -4.5054   -3.0563    0.0000 C   0  0
    3.9410   -2.8616    0.0000 C   0  0
    4.3095   -4.3156    0.0000 N   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11  8  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14  9  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 15  1  0
 18 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 26 28  1  0
 26 29  1  0
 23 30  2  0
 30 31  1  0
 31 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  1  0
 35 36  3  0
 34 37  2  0
 37 21  1  0
 37 31  1  0
  6 38  1  0
 38 39  2  0
 39  3  1  0
M  END
> <name>
UTKinase_V5

> <id>
29039

> <plate>
Kinase v5-3

> <well>
P12

> <supplier_cmpd_name>
Selpercatinib

> <ctcr_id>
14970

> <supplier_cmpd_id>
S8781

> <smiles>
COc1ccc(CN2C3CC2CN(C3)c4ccc(cn4)c5cc(OCC(C)(C)O)cn6ncc(C#N)c56)cn1

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{LOXO-292,HY-114370,Selpercatinib,Selpercatinib}

> <pdid>
PD098096

> <targets>
{RET}

> <classes>
{Protein Tyrosine Kinase/RTK}

> <pubchem_cids>
.

$$$$
UTKinase_V5
  SciTegic11012413002D

 37 42  0  0  1  0            999 V2000
   15.5920   -3.0392    0.0000 F   0  0
   14.2902   -3.7842    0.0000 C   0  0
   14.2845   -5.2842    0.0000 C   0  0
   12.9826   -6.0293    0.0000 C   0  0
   11.6864   -5.2743    0.0000 C   0  0
   11.6921   -3.7744    0.0000 C   0  0
   12.9940   -3.0293    0.0000 C   0  0
   10.3838   -6.0198    0.0000 C   0  0  2  0  0  0
   10.3786   -7.5198    0.0000 C   0  0
   10.3890   -4.5198    0.0000 N   0  0
    9.0864   -5.2653    0.0000 C   0  0
    9.0912   -3.7653    0.0000 C   0  0
    7.7945   -3.0112    0.0000 N   0  0
    6.4930   -3.7570    0.0000 C   0  0
    6.4884   -5.2570    0.0000 N   0  0
    7.7850   -6.0111    0.0000 C   0  0
    5.1945   -3.0045    0.0000 N   0  0
    5.1969   -1.5045    0.0000 C   0  0
    3.8991   -0.7525    0.0000 C   0  0
    2.5987   -1.5004    0.0000 N   0  0
    2.5965   -3.0004    0.0000 C   0  0
    3.8943   -3.7525    0.0000 C   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 N   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 N   0  0
   -2.4133   -1.7530    0.0000 C   0  0
   -1.8032   -3.1233    0.0000 C   0  0
   -0.3114   -2.9665    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
   -2.5536   -4.4230    0.0000 C   0  0
   -4.0145   -4.6748    0.0000 C   0  0
   -4.2107   -6.1619    0.0000 N   0  0
   -5.5291   -6.8773    0.0000 C   0  0
   -2.8569   -6.8080    0.0000 N   0  0
   -1.8241   -5.7201    0.0000 C   0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  2  1  0
  5  8  1  0
  8  9  1  0
  8 10  1  6
  8 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 16 11  1  0
 14 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 17  1  0
 20 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 29 30  1  0
 30 31  2  0
 31 23  1  0
 31 27  1  0
 29 32  1  0
 32 33  2  0
 33 34  1  0
 34 35  1  0
 34 36  1  0
 36 37  2  0
 37 32  1  0
M  END
> <name>
UTKinase_V5

> <id>
29040

> <plate>
Kinase v5-3

> <well>
P14

> <supplier_cmpd_name>
Avapritinib

> <ctcr_id>
12431

> <supplier_cmpd_id>
S8553

> <smiles>
Fc1ccc(cc1)[C@](C)(N)c2cnc(nc2)N3CCN(CC3)c4ncnn5cc(cc45)c6cn(C)nc6

> <pd_targets>
{KIT,PDGFRA}

> <pathway_gtopdb>
{Enzyme,Kinase,"Protein Kinase","TK protein kinase group","Tyrosine protein kinase PDGFR family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Receptor kinases","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type III RTKs: PDGFR",CSFR,Kit,"FLT3 receptor family"}

> <pathway_reactome>
{Disease,"Diseases of signal transduction by growth factor receptors and second messengers","Signaling by KIT in disease","Signaling by PDGFR in disease","Drug resistance of KIT mutants","Drug resista
nce of PDGFR mutants","Dasatinib-resistant KIT mutants","Imatinib-resistant PDGFR mutants"}

> <broad_targets>
{}

> <broad_moa>
{"KIT inhibitor"}

> <synonyms>
{Avapritinib,BLU-285,BLU285,1703793-34-3,1703793343,UNII-513P80B4YJ,UNII513P80B4YJ,513P80B4YJ,"Avapritinib (BLU-285)","Avapritinib (BLU285)",Ayvakit,Ayvakyt,MFCD31544325,"Avapritinib (INN)","Ayvakit (
TN)","Avapritinib (USAN/INN)","BLU-285 (Avapritinib)","BLU285 (Avapritinib)",CHEMBL4204794,SCHEMBL16652297,GTPL10368,T5109}

> <pdid>
PD076303

> <targets>
{"PDGFR? D842V",PDGFR¦Á,"c-Kit (D816V)"}

> <classes>
{Angiogenesis,"Tyrosine Kinase/Adaptors"}

> <pubchem_cids>
{118023034}

$$$$
UTKinase_V5
  SciTegic11012413002D

 27 30  0  0  0  0            999 V2000
    9.8970    5.1387    0.0000 C   0  0
   10.8104    3.9489    0.0000 C   0  0
    9.3959    3.8084    0.0000 C   0  0
    8.2035    2.8969    0.0000 C   0  0
    8.3970    1.4094    0.0000 O   0  0
    6.8176    3.4729    0.0000 N   0  0
    5.6273    2.5630    0.0000 C   0  0
    4.1890    2.9887    0.0000 N   0  0
    3.3397    1.7523    0.0000 C   0  0
    4.2568    0.5878    0.0000 C   0  0
    5.6669    1.0635    0.0000 S   0  0
    3.9511   -0.8815    0.0000 C   0  0
    4.9531   -1.9978    0.0000 C   0  0
    4.2010   -3.2956    0.0000 C   0  0
    2.7343   -2.9815    0.0000 N   0  0
    2.5987   -1.5004    0.0000 N   0  0
    1.2990   -0.7500    0.0000 C   0  0
    1.2990    0.7500    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 C   0  0
   -1.2990   -0.7500    0.0000 C   0  0
    0.0000   -1.5000    0.0000 C   0  0
    0.0000   -3.0000    0.0000 Cl  0  0
    2.5981    1.5000    0.0000 Cl  0  0
    4.8054   -4.6666    0.0000 C   0  0
    3.9200   -5.8774    0.0000 F   0  0
    6.2966   -4.8284    0.0000 F   0  0
  1  2  1  0
  2  3  1  0
  3  1  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  2  3
  8  9  1  0
  9 10  2  3
 10 11  1  0
 11  7  1  0
 10 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  3
 15 16  1  0
 16 12  1  0
 16 17  1  0
 17 18  2  3
 18 19  1  0
 19 20  2  3
 20 21  1  0
 21 22  2  3
 22 17  1  0
 22 23  1  0
 18 24  1  0
 14 25  1  0
 25 26  1  0
 25 27  1  0
M  END
> <name>
UTKinase_V5

> <id>
29041

> <plate>
Kinase v5-3

> <well>
P16

> <supplier_cmpd_name>
BMS-3

> <ctcr_id>
7727

> <supplier_cmpd_id>
SY-BMS-3

> <smiles>
C1CC1C(=O)NC2=NC=C(S2)C3=CC(=NN3C4=C(C=CC=C4Cl)Cl)C(F)F

> <pd_targets>
.

> <pathway_gtopdb>
.

> <pathway_chembl>
.

> <pathway_reactome>
.

> <broad_targets>
.

> <broad_moa>
.

> <synonyms>
{MS,BMS-3,BMS3,1338247-30-5,1338247305,C17H12Cl2F2N4OS,CHEMBL3182065,EX-A935,EXA935,SYN1023,BCP17224,MFCD17019326,ZINC72232825,AKOS030526418,CS-5616,CS5616,NCGC00345825-01,NCGC0034582501,NCGC00345825-
02,NCGC0034582502,NCGC00345825-03,NCGC0034582503,AK547235,AS-16194,AS16194,HY-18304,HY18304,FT-0700441,FT0700441,J-523082,J523082,SY-BMS-3}

> <pdid>
PD016994

> <targets>
{LIMK}

> <classes>
{}

> <pubchem_cids>
{73265272}

$$$$
UTKinase_V5
  SciTegic11012413002D

 20 22  0  0  0  0            999 V2000
    2.5981   -1.5000    0.0000 C   0  0
    1.2990   -0.7500    0.0000 N   0  0
    1.2990    0.7500    0.0000 C   0  0
    2.5981    1.5000    0.0000 C   0  0
    2.5981    3.0000    0.0000 C   0  0
    3.8994    3.7478    0.0000 C   0  0
    5.1973    2.9959    0.0000 O   0  0
    1.2990    3.7500    0.0000 C   0  0
    1.2990    5.2500    0.0000 C   0  0
    0.0000    3.0000    0.0000 C   0  0
    0.0000    1.5000    0.0000 C   0  0
   -1.2990    0.7500    0.0000 N   0  0
   -1.2990   -0.7500    0.0000 C   0  0
   -2.5981   -1.5000    0.0000 C   0  0
   -3.8971   -0.7500    0.0000 O   0  0
   -2.5981   -3.0000    0.0000 N   0  0
   -1.2990   -3.7500    0.0000 C   0  0
   -1.2990   -5.2500    0.0000 O   0  0
    0.0000   -3.0000    0.0000 N   0  0
    0.0000   -1.5000    0.0000 C   0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  5  8  2  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 11  3  1  0
 11 12  1  0
 12 13  2  3
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 19 20  2  3
 20  2  1  0
 20 13  1  0
M  END
> <name>
UTKinase_V5

> <id>
29042

> <plate>
Kinase v5-3

> <well>
P18

> <supplier_cmpd_name>
Ro 08-2750

> <ctcr_id>
4562

> <supplier_cmpd_id>
2272

> <smiles>
CN1c2cc(C=O)c(C)cc2N=C3C(=O)NC(=O)N=C13

> <pd_targets>
{RECQL,MAPT,BLM,NTRK1,ALD,NGF,TDP2,KMT2A,MEN1,RORC}

> <pathway_gtopdb>
{Enzyme,"Other cytosolic protein","Secreted protein","Epigenetic regulator","Transcription factor",Kinase,Phosphodiesterase,Reader,"Nuclear receptor",Protease,"Protein Kinase",Bromodomain,"Nuclear hor
mone receptor subfamily 1","Cysteine protease","TK protein kinase group","Nuclear hormone receptor subfamily 1 group F","Cysteine protease CA clan","Tyrosine protein kinase Trk family","Nuclear hormon
e receptor subfamily 1 group F member 3","Cysteine protease C1A family"}

> <pathway_chembl>
{Receptors,"Catalytic receptors","Nuclear hormone receptors","Receptor kinases","1F. Retinoic acid-related orphans","TK: Tyrosine kinase","Receptor tyrosine kinases (RTKs)","Type VII RTKs: Neurotrophi
n receptor/Trk family"}

> <pathway_reactome>
{"Neuronal System","DNA Repair","Signal Transduction","Gene expression (Transcription)","Transmission across Chemical Synapses","DNA Double-Strand Break Repair","Signaling by Receptor Tyrosine Kinases
","RNA Polymerase II Transcription","Neurotransmitter receptors and postsynaptic signal transmission","Homology Directed Repair","Signaling by NTRKs","Nonhomologous End-Joining (NHEJ)","Generic Transc
ription Pathway","Activation of NMDA receptors and postsynaptic events","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Signaling by NTRK1 (TRKA)","Transcriptional regul
ation by RUNX3","Post NMDA receptor activation events","HDR through Homologous Recombination (HRR)","Signalling to ERKs","RUNX3 Regulates Immune Response and Cell Migration","Activation of AMPK downst
ream of NMDARs","Homologous DNA Pairing and Strand Exchange","Prolonged ERK activation events","Presynaptic phase of homologous DNA pairing and strand exchange","ARMS-mediated activation"}

> <broad_targets>
{NGF,NGFR}

> <broad_moa>
{"NGF binding inhibitor"}

> <synonyms>
{"O 08275","Ro 08-2750","Ro 082750",37854-59-4,37854594,CHEMBL1397270,"7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo(g)pteridine-8-carbaldehyde","7,10dimethyl2,4dioxo2,3,4,10tetrahydrobenzo(g)pteri
dine8carbaldehyde","7,10-dimethyl-2,4-dioxobenzo(g)pteridine-8-carbaldehyde","7,10dimethyl2,4dioxobenzo(g)pteridine8carbaldehyde","7,10-dimethyl-2,4-dioxo-8-benzo(g)pteridinecarboxaldehyde","7,10dimet
hyl2,4dioxo8benzo(g)pteridinecarboxaldehyde",SCHEMBL1,2272}

> <pdid>
PD021729

> <targets>
{RTKs,TrkR,TrkA,Apoptosis}

> <classes>
{Apoptosis}

> <pubchem_cids>
{17756791}

$$$$
